Возможности лечения эстроген- и андрогендефицитных состояний у женщин с преждевременной недостаточностью яичников

1. Александрова Н.В. Прогностическая значимость методов оценки овариального резерва у женщин с преждевременной недостаточностью яичников. Дис. ... канд.  мед. наук. М., 2006.
2. Зайдиева Я.З. Гормонопрофилактика и коррекция системных нарушений у женщин в перименопаузе. Дис. ... док. мед. наук. М., 1996.
3. Сметник В.П. Климактерический период (к вопросу о терминологии). Акуш. и гинекол. 1980; 3: 3–5.
4. Сметник В.П. Преждевременная менопауза. Леч. врач. 2004; 10: 8–12.
5. Тагиева Г.В. Роль аутоиммунного процесса в генезе преждевременного выключения функции яичников. Дис. ... канд. мед. наук. М., 2005.
6. Чеботникова Т.В. Преждевременная недостаточность яичников: мнение экспертов. Вестн. репродукт. здоровья. 2007; 22–32.
7. Anasti JN. Premature ovarian failure: an update. Fertil Steril 1998; 70: 1–15.
8. Bachelot A. Ovarian steroidogenesis and serum androgen level in patient with premature ovarian failure. J Clin Endorinol Met 2005. Apr;90(4):2391–6. Epub 2005 Jan 25.
9. Bachmann G, Bancroft J, Braunstein G. et al. Female androgen insufficiency: the Princeton consensus statement on definition, classification, and assessment. Fertil Steril. 2002 Apr;77(4):660–5. 
10. Benetti-Pinto CL, Bedone AJ, Magna LA. Evaluation of serum androgen levels in women with premature ovarian failure. Fertil Steril 2005; 83: 508–10.
11. Couzinet B, Meduri G, Lecce MG, et al. The Postmenopausal Ovary Is Not a Major Androgen-Producing Gland. J Clin Endocrinol Met 2001; 86 (10): 5060–6.
12. Davis S, Schneider H, Donarti-Sarti C et al. Androgen levels in normal and oophorectomized women. Proceedings of the 10th International Congress on the Menopause, Berlin 10–14 June 2002. Climacteric 2002; 5; 219–28.
13. Dennerstein L, Dudly EC, Hopper JL et al. A prospective population-based study of menopausal symptoms. Obstet Gynecol 2000; 96: 351–8.
14. Doldi N. Premature ovarian failure: steroid syntesis and autoimmunity J. Gynecol Endocrinol 1998; 12: 23–8.
15. Ehrmann DA, Barnes RB, Rosenfield RL. et al. Polycystic ovary syndrome as a form of functional ovarian hyperandrogenism due to dysregulation of androgen secretion. Endocr Rev 1995; 16: 322–53.
16. Falsetti L, Scalchi S Villani MT et al. Premature ovarian failure. Gynecol Endocrinol. 1999; 3: 189–95. 
17. Fritz MA, Speroff L. The endocrinology of the menstrual cycle: the interaction of folliculogenesis and neuroendocrine mechanisms. Fertil Steril 1982; 38 (5): 509–29.
18. Jabara S, Christenson LK, Wang CY et al. Stromal cells of the human postmenopausal ovary display a distinctive biochemical and molecular phenotype. J Clin Endocrinol Met 2003; 88 (1): 484–92.
19. Judd HL, Lucas WE, Yen SS. Effect og oophorecromy on circulating testosterone and androstendion levels in patients with endometrial cancer. Am J Obstet Gynecol 1974; 118: 793–8.
20. Kalantaridou SN, Davis SR, Nelson LM. Premature ovarian failure. Endocrinol Metab Clin North Am 1998; 27: 989–1006.
21. Kalu E, Panay N. Spontaneous premature ovarian failure: management challenges. Gynecol Endocrinol 2008; 24 (5): 273–9.
22. Laml N, Schulz-Lobmeyr LA. Obruca Premature ovatian failure: etiology and prospects. Gynecol Endocrinol 2000; 14: 292–302.
23. Laughlin GA, Barret-Conner E, Kritz-Silverstein D, von Muhlen D. Hysterectomy, oophorectomy, and endogenous sex hormone levels in older women: the Ranco Bernardo Study. Clin Endocrinol Met 2000; 85: 645–51.
24. Liu CH, Laughlin GA, Fischer UG et al. Marked attenuation of ultradian and circadian rhythms of dehydroepiandrosterone in postmenopausal women: evidence for a reduced 17,20 desmolase enzymatic activity. J Clin Endocrinol Met 1990; 71: 900–6.
25. McDermott W, Amorosimo C. Hirsutism-beyond the steroidogenic block. N Engl J Med 1990; 13: 909–11. 
26. Meduri G, Tourane P, Beau I et al. Delayed puberty and primary amenorrhea associated with a novel mutation of the human follicle-stimulating hormone receptor: clinical, histological and molecular studies. J Clin Endocrinol Met 2003; 88: 3491–8.
27. Mushayandevu T, Castracane VD, Gimpel T et al. Evidence for diminished midcycle ovarian androgen production in older reproductive aged women. Fertil Steril 1996; 65: 721–3.
28. Orentreich N, Brind JL, Riser RL et al. Age changes and sex differences in serum dehydroepianrosterone sulfate concentrations throughout adulthood. J Clin Endocrinol Met 1984; 59: 551–5.
29 Parker CR, Mixon RL, Brissie RM et al. Effects of aging on adrenal function in the human: Responsivness and sensitivity of adrenal androgens and cortisol to adrenocorticotropin in premenopausal and postmenopausal women. J Clin Endocrinol Met 2000; 85: 48–54.
30. Simpson ER. Role of aromatase in sex steroid action. J Mol Endocrinol 2000; 25: 149–56.
31. Taylor A, Adams J, Mulder J et al. A randomized, controlled trial of estradiol replacement therapy in women with hypergonadotropic amenorrhea. J Clin Endocrinol Met 1996; 81: 3615–21.
32. Utian WH, Serr D. Consensus on Menopause Research. Ed. P.A. van Keep et al. Lancaster, 1976: 1–4.
33. Welt CK, Smith PC, Taylor AE et al. Evidence of early ovarian aging in fragile X premutation carriers. J Clin. Endocrinol Met 1999; 84: 105–11. 
34. Zumoff B, Stain GW, Miller LK et al. Twenty-four – hour mean plasma testosterone concentration declines with age in normal premenopausal women. J Clin Endocrinol Met 1995; 80: 1429–30.

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1. Александрова Н.В. Прогностическая значимость методов оценки овариального резерва у женщин с преждевременной недостаточностью яичников. Дис. ... канд.  мед. наук. М., 2006.
2. Зайдиева Я.З. Гормонопрофилактика и коррекция системных нарушений у женщин в перименопаузе. Дис. ... док. мед. наук. М., 1996.
3. Сметник В.П. Климактерический период (к вопросу о терминологии). Акуш. и гинекол. 1980; 3: 3–5.
4. Сметник В.П. Преждевременная менопауза. Леч. врач. 2004; 10: 8–12.
5. Тагиева Г.В. Роль аутоиммунного процесса в генезе преждевременного выключения функции яичников. Дис. ... канд. мед. наук. М., 2005.
6. Чеботникова Т.В. Преждевременная недостаточность яичников: мнение экспертов. Вестн. репродукт. здоровья. 2007; 22–32.
7. Anasti JN. Premature ovarian failure: an update. Fertil Steril 1998; 70: 1–15.
8. Bachelot A. Ovarian steroidogenesis and serum androgen level in patient with premature ovarian failure. J Clin Endorinol Met 2005. Apr;90(4):2391–6. Epub 2005 Jan 25.
9. Bachmann G, Bancroft J, Braunstein G. et al. Female androgen insufficiency: the Princeton consensus statement on definition, classification, and assessment. Fertil Steril. 2002 Apr;77(4):660–5. 
10. Benetti-Pinto CL, Bedone AJ, Magna LA. Evaluation of serum androgen levels in women with premature ovarian failure. Fertil Steril 2005; 83: 508–10.
11. Couzinet B, Meduri G, Lecce MG, et al. The Postmenopausal Ovary Is Not a Major Androgen-Producing Gland. J Clin Endocrinol Met 2001; 86 (10): 5060–6.
12. Davis S, Schneider H, Donarti-Sarti C et al. Androgen levels in normal and oophorectomized women. Proceedings of the 10th International Congress on the Menopause, Berlin 10–14 June 2002. Climacteric 2002; 5; 219–28.
13. Dennerstein L, Dudly EC, Hopper JL et al. A prospective population-based study of menopausal symptoms. Obstet Gynecol 2000; 96: 351–8.
14. Doldi N. Premature ovarian failure: steroid syntesis and autoimmunity J. Gynecol Endocrinol 1998; 12: 23–8.
15. Ehrmann DA, Barnes RB, Rosenfield RL. et al. Polycystic ovary syndrome as a form of functional ovarian hyperandrogenism due to dysregulation of androgen secretion. Endocr Rev 1995; 16: 322–53.
16. Falsetti L, Scalchi S Villani MT et al. Premature ovarian failure. Gynecol Endocrinol. 1999; 3: 189–95. 
17. Fritz MA, Speroff L. The endocrinology of the menstrual cycle: the interaction of folliculogenesis and neuroendocrine mechanisms. Fertil Steril 1982; 38 (5): 509–29.
18. Jabara S, Christenson LK, Wang CY et al. Stromal cells of the human postmenopausal ovary display a distinctive biochemical and molecular phenotype. J Clin Endocrinol Met 2003; 88 (1): 484–92.
19. Judd HL, Lucas WE, Yen SS. Effect og oophorecromy on circulating testosterone and androstendion levels in patients with endometrial cancer. Am J Obstet Gynecol 1974; 118: 793–8.
20. Kalantaridou SN, Davis SR, Nelson LM. Premature ovarian failure. Endocrinol Metab Clin North Am 1998; 27: 989–1006.
21. Kalu E, Panay N. Spontaneous premature ovarian failure: management challenges. Gynecol Endocrinol 2008; 24 (5): 273–9.
22. Laml N, Schulz-Lobmeyr LA. Obruca Premature ovatian failure: etiology and prospects. Gynecol Endocrinol 2000; 14: 292–302.
23. Laughlin GA, Barret-Conner E, Kritz-Silverstein D, von Muhlen D. Hysterectomy, oophorectomy, and endogenous sex hormone levels in older women: the Ranco Bernardo Study. Clin Endocrinol Met 2000; 85: 645–51.
24. Liu CH, Laughlin GA, Fischer UG et al. Marked attenuation of ultradian and circadian rhythms of dehydroepiandrosterone in postmenopausal women: evidence for a reduced 17,20 desmolase enzymatic activity. J Clin Endocrinol Met 1990; 71: 900–6.
25. McDermott W, Amorosimo C. Hirsutism-beyond the steroidogenic block. N Engl J Med 1990; 13: 909–11. 
26. Meduri G, Tourane P, Beau I et al. Delayed puberty and primary amenorrhea associated with a novel mutation of the human follicle-stimulating hormone receptor: clinical, histological and molecular studies. J Clin Endocrinol Met 2003; 88: 3491–8.
27. Mushayandevu T, Castracane VD, Gimpel T et al. Evidence for diminished midcycle ovarian androgen production in older reproductive aged women. Fertil Steril 1996; 65: 721–3.
28. Orentreich N, Brind JL, Riser RL et al. Age changes and sex differences in serum dehydroepianrosterone sulfate concentrations throughout adulthood. J Clin Endocrinol Met 1984; 59: 551–5.
29 Parker CR, Mixon RL, Brissie RM et al. Effects of aging on adrenal function in the human: Responsivness and sensitivity of adrenal androgens and cortisol to adrenocorticotropin in premenopausal and postmenopausal women. J Clin Endocrinol Met 2000; 85: 48–54.
30. Simpson ER. Role of aromatase in sex steroid action. J Mol Endocrinol 2000; 25: 149–56.
31. Taylor A, Adams J, Mulder J et al. A randomized, controlled trial of estradiol replacement therapy in women with hypergonadotropic amenorrhea. J Clin Endocrinol Met 1996; 81: 3615–21.
32. Utian WH, Serr D. Consensus on Menopause Research. Ed. P.A. van Keep et al. Lancaster, 1976: 1–4.
33. Welt CK, Smith PC, Taylor AE et al. Evidence of early ovarian aging in fragile X premutation carriers. J Clin. Endocrinol Met 1999; 84: 105–11. 
34. Zumoff B, Stain GW, Miller LK et al. Twenty-four – hour mean plasma testosterone concentration declines with age in normal premenopausal women. J Clin Endocrinol Met 1995; 80: 1429–30.

Г.И.Табеева, Л.А.Марченко, Л.Б.Бутарева, З.Г.Габибуллаева

ФГУ «НЦ акушерства, гинекологии и перинатологии им. акад. РАМН В.Н.Кулакова»
(дир. – акад. РАМН Г.Т.Сухих), Москва