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Доброкачественные гиперплазии матки и внутриматочная левоноргестрел-рилизинг система
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Ключевые слова: миома матки, аденомиоз, гиперплазии эндометрия, алгоритм лечения, внутриматочная левоноргестрел-рилизинг система Мирена.
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The algorithm of the complex conservative treatment of uterine myoma depending on the units sizes is represented. The effectiveness of the intrauterine levonorgestrel-releasing system Mirena is pathogenetically and clinically substantiated in the independent treatment of the small units of myoma and as the anti-relapse therapy after miomectomy and hormonal-ablation therapy. Proposed therapeutic approaches are directed to the expansion of the possibility of using the conservative treatment of patients with uterine myoma.
Key words: uterine myoma, adenomyosis, hyperplasia of endometrium, the algorithm of treatment, intrauterine levonorgestrel-releasing system Mirena.
2. Сидорова И.С. Миома матки. М.: Медицинское информационное агентство, 2005.
3. Тихомиров А.Л., Залеева Е.В. Роль левоноргестрел-рилизинг системы в комплексном лечении миомы матки. Актуальные вопросы клинической транспортной медицины, 2006.
4. Тихомиров А.Л., Лубнин Д.М. Контрацепция у больных миомой матки. Рус. мед. журн. 2002; 10 (4): 212–15.
5. Тихомиров А.Л., Лубнин Д.М. Миома матки. М.: Медицинское информационное агентство, 2006.
6. Тихомиров А.Л., Лубнин Д.М. Новый принцип лечения миомы матки. Методическое руководство для врачей акушеров-гинекологов. М., 2006.
7. Тихомиров А.Л., Тускаев К.С., Залеева Е.В. Применение внутриматочной гормональной рилизинг-системы в комплексном органосохраняющем лечении миомы матки. Методическое руководство для врачей акушеров-гинекологов. М., 2005.
8. Bahamondes, Ribeiro-Huguet. Levonorgestrel-releasing intrauterine system (Mirena) as a therapy for endometrial hyperplasia and carcinoma. Acta Obstet Gynecol Scand 2003; 82 (6): 580–2.
9. Baldaszti E, Wimmer-Puchinger B. Acceptability of the long-term contraceptive levonorgestrel-releasing intrauterine system (Mirena): a 3-year follow-up study. Contraception 2003; 67 (2): 87–91.
10. Fedele L, Bianchi S, Raffaelli R et al. Treatment of adenomyosis-associated menorrhagia with a levonorgestrel-releasing intrauterine device. Fertil Steril 1997; 68: 426–29.
11. Fedele L, Bianchi S, Zanconato G et al. Use of a levonorgestrel-releasing intrauterine device in the treatment of recto- vaginal endometriosis. Fertil Steril 2001; 75: 485–88.
12. French RS, Cowan FM, Mansour D et al. Levonorgestrel-releasing (20 microgram/day) intrauterine systems (Mirena) compared with other methods of reversible contraceptives. Bjog 2000; 107 (10): 1218–25.
13. Giannopoulos T, Butler-Manuel S et al. Levonorgestrel-releasing intrauterine system (LNG-IUS) as a therapy for endometrial carcinoma. Gynecol Oncol 2004; 95 (3): 762–4.
14. Laoag-Fernandez JB, Maruo T et al. Effects of levonorgestrel-releasing intra-uterine system on the expression of vascular endothelial growth factor and adrenomedullin in the endometrium in adenomyosis. Hum Reprod 2003; 18 (4): 694–9.
15. Levy BS. Management of uterine fibroids. Acta Obstet Gynecol Scand 2008; 87 (8): 812–23.
16. Maia H, Maltez A. Insertion of mirena after endometrial resection in patients with adenomyosis. J Am Assoc Gynecol Laparosc 2003; 10 (4): 512–6.
17. Perino A, Quartararo P, Catinella E et al. Тreatment of endometrial hyperplasis with levonorgestrel-releasing intrauterine devices. Acta Fertil 1987.
18. Rachev E. Mirena – the first intrauterine contraceptive rherapeutic system. Akush Ginekol (Sofiia) 2001; 40 (Suppl. 6): 3–6.
19. Rein MS. Advances in uterine leiomyoma research: the progesterone hypothesis. Environ. Health Perspect 2000; 108 (5): 791–3.
20. Searselli G, Tantini C, Colafranceschi M et al. Levonorgestrel-releasing intrauterine devices and precancerous lesious of the endometrium. Eur J Gynaecol Oncol 1988; 9 (4): 284–86.
21. Tiltman AJ. Smooth muscle neoplasms of the uterus. Curr Opin Obstet Gynecol 1997; 9 (1): 48–51.
22. Vercellini P, Aimi G, Panazza S et al. A levonorgestrel-releasing intrauterine system for the treatment of dysmenorrhea associated with endometriosis: a pilot study. Fertil Steril 1999; 72 (3): 505–8.
23. Vollenboven BJ, Lawrence AS, Healy DL. Uterine fibroids 1997; 97: 285–98.
24. Wang S, Su Q. Clonality of multiple uterine leiomyomas. Zhonghua Bing Li Xue Za Zhi 2002; 31 (2): 107–11.
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1. Вихляева Е.М. О стратегии и тактике ведения больных с миомой матки. Вестн. рос. ассоц. акушеров-гинекологов. 1997; 3: 21–3.
2. Сидорова И.С. Миома матки. М.: Медицинское информационное агентство, 2005.
3. Тихомиров А.Л., Залеева Е.В. Роль левоноргестрел-рилизинг системы в комплексном лечении миомы матки. Актуальные вопросы клинической транспортной медицины, 2006.
4. Тихомиров А.Л., Лубнин Д.М. Контрацепция у больных миомой матки. Рус. мед. журн. 2002; 10 (4): 212–15.
5. Тихомиров А.Л., Лубнин Д.М. Миома матки. М.: Медицинское информационное агентство, 2006.
6. Тихомиров А.Л., Лубнин Д.М. Новый принцип лечения миомы матки. Методическое руководство для врачей акушеров-гинекологов. М., 2006.
7. Тихомиров А.Л., Тускаев К.С., Залеева Е.В. Применение внутриматочной гормональной рилизинг-системы в комплексном органосохраняющем лечении миомы матки. Методическое руководство для врачей акушеров-гинекологов. М., 2005.
8. Bahamondes, Ribeiro-Huguet. Levonorgestrel-releasing intrauterine system (Mirena) as a therapy for endometrial hyperplasia and carcinoma. Acta Obstet Gynecol Scand 2003; 82 (6): 580–2.
9. Baldaszti E, Wimmer-Puchinger B. Acceptability of the long-term contraceptive levonorgestrel-releasing intrauterine system (Mirena): a 3-year follow-up study. Contraception 2003; 67 (2): 87–91.
10. Fedele L, Bianchi S, Raffaelli R et al. Treatment of adenomyosis-associated menorrhagia with a levonorgestrel-releasing intrauterine device. Fertil Steril 1997; 68: 426–29.
11. Fedele L, Bianchi S, Zanconato G et al. Use of a levonorgestrel-releasing intrauterine device in the treatment of recto- vaginal endometriosis. Fertil Steril 2001; 75: 485–88.
12. French RS, Cowan FM, Mansour D et al. Levonorgestrel-releasing (20 microgram/day) intrauterine systems (Mirena) compared with other methods of reversible contraceptives. Bjog 2000; 107 (10): 1218–25.
13. Giannopoulos T, Butler-Manuel S et al. Levonorgestrel-releasing intrauterine system (LNG-IUS) as a therapy for endometrial carcinoma. Gynecol Oncol 2004; 95 (3): 762–4.
14. Laoag-Fernandez JB, Maruo T et al. Effects of levonorgestrel-releasing intra-uterine system on the expression of vascular endothelial growth factor and adrenomedullin in the endometrium in adenomyosis. Hum Reprod 2003; 18 (4): 694–9.
15. Levy BS. Management of uterine fibroids. Acta Obstet Gynecol Scand 2008; 87 (8): 812–23.
16. Maia H, Maltez A. Insertion of mirena after endometrial resection in patients with adenomyosis. J Am Assoc Gynecol Laparosc 2003; 10 (4): 512–6.
17. Perino A, Quartararo P, Catinella E et al. Тreatment of endometrial hyperplasis with levonorgestrel-releasing intrauterine devices. Acta Fertil 1987.
18. Rachev E. Mirena – the first intrauterine contraceptive rherapeutic system. Akush Ginekol (Sofiia) 2001; 40 (Suppl. 6): 3–6.
19. Rein MS. Advances in uterine leiomyoma research: the progesterone hypothesis. Environ. Health Perspect 2000; 108 (5): 791–3.
20. Searselli G, Tantini C, Colafranceschi M et al. Levonorgestrel-releasing intrauterine devices and precancerous lesious of the endometrium. Eur J Gynaecol Oncol 1988; 9 (4): 284–86.
21. Tiltman AJ. Smooth muscle neoplasms of the uterus. Curr Opin Obstet Gynecol 1997; 9 (1): 48–51.
22. Vercellini P, Aimi G, Panazza S et al. A levonorgestrel-releasing intrauterine system for the treatment of dysmenorrhea associated with endometriosis: a pilot study. Fertil Steril 1999; 72 (3): 505–8.
23. Vollenboven BJ, Lawrence AS, Healy DL. Uterine fibroids 1997; 97: 285–98.
24. Wang S, Su Q. Clonality of multiple uterine leiomyomas. Zhonghua Bing Li Xue Za Zhi 2002; 31 (2): 107–11.
Московский государственный медико-стоматологический университет
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A.L.Tikhomirov, A.A.Ledenkova