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Фитоэстрогены в лечении климактерических расстройств
Фитоэстрогены в лечении климактерических расстройств
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Аннотация
В периоде менопаузального перехода на фоне общих возрастных изменений доминируют инволюционные процессы в репродуктивной системе, связанные с выключением овариальной функции. В настоящее время ведущим методом коррекции климактерического синдрома признается заместительная гормональная терапия, но не все женщины с патологическим течением климакса могут и хотят принимать гормональные препараты. Альтернативный метод купирования менопаузальных расстройств состоит в назначении фитоэстрогенов, что облегчает приливы жара и улучшает общее самочувствие женщин. Однако фитоэстрогены не способны полностью удовлетворить все потребности организма по предотвращению болезней старения, поэтому привлекательно выглядят комплексные препараты, в состав которых вводятся антиоксиданты (например, ресвератрол), полезные для сердечно-сосудистой системы, витамины, предотвращающие развитие остеопороза (витамины D и К). Применение подобных препаратов должно способствовать не только улучшению качества жизни женщин, но и снижению риска кардиометаболических заболеваний и остеопороза.
Ключевые слова: менопауза, приливы жара, качество жизни, остеопороз, фитоэстрогены, генистеин, ресвератрол, витамин D.
Key words: menopause, hot flashes, quality of life, osteoporosis, phytoestrogens, henistein, resveratrol, vitamin D.
Ключевые слова: менопауза, приливы жара, качество жизни, остеопороз, фитоэстрогены, генистеин, ресвератрол, витамин D.
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Key words: menopause, hot flashes, quality of life, osteoporosis, phytoestrogens, henistein, resveratrol, vitamin D.
Полный текст
Список литературы
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2. Сметник В.П., Ильина Л.М. Роль половых гормонов в развитии метаболических расстройств у женщин в пери- и ранней постменопаузе. Климактерий. 2009; 1: 8–13.
3. Naftolin F, Schneider HP, Sturdee DW et al. Executive Committee of the International Menopause Society. Guidelines for hormone treatment of women in the menopausal transition and beyond. Climacteric 2004; 7: 333–7.
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14. Munro IC, Harwood M, Hlywka JJ et al. Soy isoflavons: a safety review. Nutr Rev 2003; 61: 1–33.
15. Ohmichi M, Tasaka K et al. Molecular mechanism of action of Selective Estrogen Receptor Modulator in target tissues. J Endocr 2005; 52 (2): 161–7.
16. Roemheld-Hamm B. Chastberry. Am Fam Physician 2005; 72: 821–4.
17. Unfer V, Casini ML, Costabile L et al. Endometrial effects of long-term treatment with phytoestrogens: a randomized, double-blind, placebo-controlled study. Fertil Steril 2004; 82: 145–8.
18. Pervaiz S. Resveratrol: from grapevines to mammalian biology. FASEB J 2003; 17: 1975–85.
19. Belleri M, Ribatti D, Savio M et al. αvβ3 Integrin-dependent antiagiogenic activity of resveratrol stereoisomers. Mol Cancer Ther 2008; 7: 3761–70.
20. Dawson-Huges B. Vitamin D, calcium and bone – what`s the latest? Osteoporosis Int 2011; 22 (5): S684–S685.
21. Ginde AA, Scragg R, Schwartz RS, Camargo CA. Prospective study of serum 25-hydroxyvitamin D level, cardiovascular disease mortality, and all cause mortality in older U.S. adults. J Am Geriatr Soc 2009; 57 (9): 1595–603.
22. Scragg R, Sowers M, Bell C. Serum 25-hydroxyvitamin D, ethnicity, and blood pressure in the Third National Health and Nutrition Examination Survey. Am J Hypertens 2007; 20 (7): 713–9.
23. Forman JP, Bischoff-Ferrari HA, Willett WC et al. Vitamin D intake and risk of incident hypertension: results from three large prospective cohort studies. Hypertension 2005; 46 (4): 676–2.
2. Сметник В.П., Ильина Л.М. Роль половых гормонов в развитии метаболических расстройств у женщин в пери- и ранней постменопаузе. Климактерий. 2009; 1: 8–13.
3. Naftolin F, Schneider HP, Sturdee DW et al. Executive Committee of the International Menopause Society. Guidelines for hormone treatment of women in the menopausal transition and beyond. Climacteric 2004; 7: 333–7.
4. Cronenberg F, Fugh-Berman A. Complementary and alternative medicine for menopausal symptoms: a review of randomized, controlled trials. Ann Intern Med 2002; 137: 805–13.
5. Wuttke W, Jarry H, Westphalen S et al. Phytoestrogens for hormone replacement therapy? J Steroid Bichem Mol Biol 2002; 83: 133–47.
6. Albertazzi P, Steel SA, Clifford E et al. Attitudes towards and use of dietary supplementation in a sample of postmenopausal women. Climacteric 2002; 5: 374–82.
7. Krebs EE, Ensrud KE, MacDonald R et al. Phytoestrogens for treatment of menopausal symptoms: a systematic review. Obstet Gynecol 2004; 104: 824–36.
8. Geller SE, Studee L. Botanical and dietary supplements for menopausal symptoms: what works, what does not. J Womens Health (Larchmt) 2005; 14: 634–49.
9. Philp HA. Hot flashes a review of the literature on alternative and complementary treatment approaches. Alter Med Rev 2003; 8: 284–302.
10. Blumenthal M. Herbal Medicine: Expanded Commision E Monographs. Newton, MA: Integrative Medicine Communications, 2003.
11. Здоровье женщин и менопауза. Пер. с англ. М.: ГЭОТАР-МЕД, 2004.
12. Genazzani A.R. Non hormonal treatment of hot flushes. Congr book 7th Congr Eur Soc Gynecol, Paris 2007; p. 49.
13. Carrati B, Sanzini E. Biologically-active phytochemicals in vegetable food. Ann Ist Super Sanita 2005; 41: 7–16.
14. Munro IC, Harwood M, Hlywka JJ et al. Soy isoflavons: a safety review. Nutr Rev 2003; 61: 1–33.
15. Ohmichi M, Tasaka K et al. Molecular mechanism of action of Selective Estrogen Receptor Modulator in target tissues. J Endocr 2005; 52 (2): 161–7.
16. Roemheld-Hamm B. Chastberry. Am Fam Physician 2005; 72: 821–4.
17. Unfer V, Casini ML, Costabile L et al. Endometrial effects of long-term treatment with phytoestrogens: a randomized, double-blind, placebo-controlled study. Fertil Steril 2004; 82: 145–8.
18. Pervaiz S. Resveratrol: from grapevines to mammalian biology. FASEB J 2003; 17: 1975–85.
19. Belleri M, Ribatti D, Savio M et al. αvβ3 Integrin-dependent antiagiogenic activity of resveratrol stereoisomers. Mol Cancer Ther 2008; 7: 3761–70.
20. Dawson-Huges B. Vitamin D, calcium and bone – what`s the latest? Osteoporosis Int 2011; 22 (5): S684–S685.
21. Ginde AA, Scragg R, Schwartz RS, Camargo CA. Prospective study of serum 25-hydroxyvitamin D level, cardiovascular disease mortality, and all cause mortality in older U.S. adults. J Am Geriatr Soc 2009; 57 (9): 1595–603.
22. Scragg R, Sowers M, Bell C. Serum 25-hydroxyvitamin D, ethnicity, and blood pressure in the Third National Health and Nutrition Examination Survey. Am J Hypertens 2007; 20 (7): 713–9.
23. Forman JP, Bischoff-Ferrari HA, Willett WC et al. Vitamin D intake and risk of incident hypertension: results from three large prospective cohort studies. Hypertension 2005; 46 (4): 676–2.
2. Сметник В.П., Ильина Л.М. Роль половых гормонов в развитии метаболических расстройств у женщин в пери- и ранней постменопаузе. Климактерий. 2009; 1: 8–13.
3. Naftolin F, Schneider HP, Sturdee DW et al. Executive Committee of the International Menopause Society. Guidelines for hormone treatment of women in the menopausal transition and beyond. Climacteric 2004; 7: 333–7.
4. Cronenberg F, Fugh-Berman A. Complementary and alternative medicine for menopausal symptoms: a review of randomized, controlled trials. Ann Intern Med 2002; 137: 805–13.
5. Wuttke W, Jarry H, Westphalen S et al. Phytoestrogens for hormone replacement therapy? J Steroid Bichem Mol Biol 2002; 83: 133–47.
6. Albertazzi P, Steel SA, Clifford E et al. Attitudes towards and use of dietary supplementation in a sample of postmenopausal women. Climacteric 2002; 5: 374–82.
7. Krebs EE, Ensrud KE, MacDonald R et al. Phytoestrogens for treatment of menopausal symptoms: a systematic review. Obstet Gynecol 2004; 104: 824–36.
8. Geller SE, Studee L. Botanical and dietary supplements for menopausal symptoms: what works, what does not. J Womens Health (Larchmt) 2005; 14: 634–49.
9. Philp HA. Hot flashes a review of the literature on alternative and complementary treatment approaches. Alter Med Rev 2003; 8: 284–302.
10. Blumenthal M. Herbal Medicine: Expanded Commision E Monographs. Newton, MA: Integrative Medicine Communications, 2003.
11. Здоровье женщин и менопауза. Пер. с англ. М.: ГЭОТАР-МЕД, 2004.
12. Genazzani A.R. Non hormonal treatment of hot flushes. Congr book 7th Congr Eur Soc Gynecol, Paris 2007; p. 49.
13. Carrati B, Sanzini E. Biologically-active phytochemicals in vegetable food. Ann Ist Super Sanita 2005; 41: 7–16.
14. Munro IC, Harwood M, Hlywka JJ et al. Soy isoflavons: a safety review. Nutr Rev 2003; 61: 1–33.
15. Ohmichi M, Tasaka K et al. Molecular mechanism of action of Selective Estrogen Receptor Modulator in target tissues. J Endocr 2005; 52 (2): 161–7.
16. Roemheld-Hamm B. Chastberry. Am Fam Physician 2005; 72: 821–4.
17. Unfer V, Casini ML, Costabile L et al. Endometrial effects of long-term treatment with phytoestrogens: a randomized, double-blind, placebo-controlled study. Fertil Steril 2004; 82: 145–8.
18. Pervaiz S. Resveratrol: from grapevines to mammalian biology. FASEB J 2003; 17: 1975–85.
19. Belleri M, Ribatti D, Savio M et al. αvβ3 Integrin-dependent antiagiogenic activity of resveratrol stereoisomers. Mol Cancer Ther 2008; 7: 3761–70.
20. Dawson-Huges B. Vitamin D, calcium and bone – what`s the latest? Osteoporosis Int 2011; 22 (5): S684–S685.
21. Ginde AA, Scragg R, Schwartz RS, Camargo CA. Prospective study of serum 25-hydroxyvitamin D level, cardiovascular disease mortality, and all cause mortality in older U.S. adults. J Am Geriatr Soc 2009; 57 (9): 1595–603.
22. Scragg R, Sowers M, Bell C. Serum 25-hydroxyvitamin D, ethnicity, and blood pressure in the Third National Health and Nutrition Examination Survey. Am J Hypertens 2007; 20 (7): 713–9.
23. Forman JP, Bischoff-Ferrari HA, Willett WC et al. Vitamin D intake and risk of incident hypertension: results from three large prospective cohort studies. Hypertension 2005; 46 (4): 676–2.
________________________________________________
2. Сметник В.П., Ильина Л.М. Роль половых гормонов в развитии метаболических расстройств у женщин в пери- и ранней постменопаузе. Климактерий. 2009; 1: 8–13.
3. Naftolin F, Schneider HP, Sturdee DW et al. Executive Committee of the International Menopause Society. Guidelines for hormone treatment of women in the menopausal transition and beyond. Climacteric 2004; 7: 333–7.
4. Cronenberg F, Fugh-Berman A. Complementary and alternative medicine for menopausal symptoms: a review of randomized, controlled trials. Ann Intern Med 2002; 137: 805–13.
5. Wuttke W, Jarry H, Westphalen S et al. Phytoestrogens for hormone replacement therapy? J Steroid Bichem Mol Biol 2002; 83: 133–47.
6. Albertazzi P, Steel SA, Clifford E et al. Attitudes towards and use of dietary supplementation in a sample of postmenopausal women. Climacteric 2002; 5: 374–82.
7. Krebs EE, Ensrud KE, MacDonald R et al. Phytoestrogens for treatment of menopausal symptoms: a systematic review. Obstet Gynecol 2004; 104: 824–36.
8. Geller SE, Studee L. Botanical and dietary supplements for menopausal symptoms: what works, what does not. J Womens Health (Larchmt) 2005; 14: 634–49.
9. Philp HA. Hot flashes a review of the literature on alternative and complementary treatment approaches. Alter Med Rev 2003; 8: 284–302.
10. Blumenthal M. Herbal Medicine: Expanded Commision E Monographs. Newton, MA: Integrative Medicine Communications, 2003.
11. Здоровье женщин и менопауза. Пер. с англ. М.: ГЭОТАР-МЕД, 2004.
12. Genazzani A.R. Non hormonal treatment of hot flushes. Congr book 7th Congr Eur Soc Gynecol, Paris 2007; p. 49.
13. Carrati B, Sanzini E. Biologically-active phytochemicals in vegetable food. Ann Ist Super Sanita 2005; 41: 7–16.
14. Munro IC, Harwood M, Hlywka JJ et al. Soy isoflavons: a safety review. Nutr Rev 2003; 61: 1–33.
15. Ohmichi M, Tasaka K et al. Molecular mechanism of action of Selective Estrogen Receptor Modulator in target tissues. J Endocr 2005; 52 (2): 161–7.
16. Roemheld-Hamm B. Chastberry. Am Fam Physician 2005; 72: 821–4.
17. Unfer V, Casini ML, Costabile L et al. Endometrial effects of long-term treatment with phytoestrogens: a randomized, double-blind, placebo-controlled study. Fertil Steril 2004; 82: 145–8.
18. Pervaiz S. Resveratrol: from grapevines to mammalian biology. FASEB J 2003; 17: 1975–85.
19. Belleri M, Ribatti D, Savio M et al. αvβ3 Integrin-dependent antiagiogenic activity of resveratrol stereoisomers. Mol Cancer Ther 2008; 7: 3761–70.
20. Dawson-Huges B. Vitamin D, calcium and bone – what`s the latest? Osteoporosis Int 2011; 22 (5): S684–S685.
21. Ginde AA, Scragg R, Schwartz RS, Camargo CA. Prospective study of serum 25-hydroxyvitamin D level, cardiovascular disease mortality, and all cause mortality in older U.S. adults. J Am Geriatr Soc 2009; 57 (9): 1595–603.
22. Scragg R, Sowers M, Bell C. Serum 25-hydroxyvitamin D, ethnicity, and blood pressure in the Third National Health and Nutrition Examination Survey. Am J Hypertens 2007; 20 (7): 713–9.
23. Forman JP, Bischoff-Ferrari HA, Willett WC et al. Vitamin D intake and risk of incident hypertension: results from three large prospective cohort studies. Hypertension 2005; 46 (4): 676–2.
Авторы
И.В.Кузнецова
ГБОУ ВПО Первый МГМУ им. И.М.Сеченова Минздрава РФ
ГБОУ ВПО Первый МГМУ им. И.М.Сеченова Минздрава РФ
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