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Хламидийная инфекция во время беременности и ее влияние на состояние плода и новорожденного, ретроспективный анализ безопасности применения Сумамеда (азитромицина) у беременных
Хламидийная инфекция во время беременности и ее влияние на состояние плода и новорожденного, ретроспективный анализ безопасности применения Сумамеда (азитромицина) у беременных
Материалы доступны только для специалистов сферы здравоохранения. Авторизуйтесь или зарегистрируйтесь.
Аннотация
В статье показано влияние хламидийной инфекции на течение беременности, необходимость лечения, представлено ретроспективное исследование применения оригинального препарата азитромицин (Сумамед) у женщин во время беременности с оценкой безопасности его применения на состояние новорожденных.
Ключевые слова: хламидийная инфекция, беременность, роды, новорожденный, лечение, азитромицин.
Key words: chlamydial infection , pregnancy, delivery, new-born, treatment, azithromycin.
Ключевые слова: хламидийная инфекция, беременность, роды, новорожденный, лечение, азитромицин.
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Key words: chlamydial infection , pregnancy, delivery, new-born, treatment, azithromycin.
Полный текст
Список литературы
1. Chen MY, Fairley CK, De Guingand D et al. Screening pregnant women for chlamydia: what are the predictors of infection? Sex Transm Infect 2009; 85 (1): 31–5. Epub 2008.
2. Oakeshott P, Kerry S, Aghaizu A et al. Randomised controlled trial of screening for Chlamydia trachomatis to prevent pelvic inflammatory disease: the POPI (prevention of pelvic infection) trial. BMJ 2010; 340: 1642.
3. Andrews WW, Goldenberg RL, Mercer B et al. The Preterm Prediction Study: association of second-trimester genitourinary Chlamydia infection with subsequent spontaneous preterm birth. Am J Obstet Gynecol 2000; 183: 662–8.
4. Baud D, Regan L, Greub G. Emerging role of Chlamydia and Chlamydia-like organisms in adverse pregnancy outcomes. Curr Opin Infect Dis 2008; 21: 70–6.
5. Kovacs L, Nagy E, Berbik I et al. The frequency and the role of Chlamydia trachomatis infection in premature labor. Int J Gynaecol Obstet 1998; 62: 47–54.
6. Lanjouw E, Ossewaarde JM, Stary A et al. 2010 European guideline for the management of Chlamydia trachomatis infections. Int J STD AIDS 2010; 21 (11): 729–37.
7. Workowski KA, Berman S. Centers for Disease Control and Prevention (CDC). Sexually Transmitted Diseases Treatment Guidelines, 2010. MMWR Recomm Rep 2010; 59 (RR-12): 1–10.
8. Kacmar J, Cheh E, Montagno A, Peipert JF. A randomized trial of azithromycin versus amoxicillin for the treatment of Chlamydia trachomatis in pregnancy. Infect Dis Obstet Gynecol 2001; 9: 197–202.
9. Jacobson GF, Autry AM, Kirby RS et al. A randomized controlled trial comparing amoxicillin and azithromycin for the treatment of Chlamydia trachomatis in pregnancy. Am J Obstet Gynecol 2001; 184: 1352–4.
10. Pitsouni E, Iavazzo C, Athanasiou S, Falagas ME. Single-dose azithromycin versus erythromycin oramoxicillin for Chlamydia trachomatis infectionduring pregnancy: a meta-analysis of randomizedcontrolled trials. Int J Antimicrob Agents 2007; 30 (3): 213–21.
11. Centers for Disease Control and Prevention. Sexually Transmitted Diseases Treatment Guidelines 2006. MMWR 2006; 55 (№RR-11).
12. Adair CD, Gunter M, Stovall TG et al. Chlamydia in pregnancy: a randomized trial of azithromycin and erythromycin. Obstet Gynecol 1998; 91: 165–8.
13. Heikkinen T, Laine K, Neuvonen PJ et al. The transplacental transfer of the macrolide antibiotics erythromycin, roxithromycin and azithromycin. Br J Obstet Gynocol 2000; 107 (6): 770–5.
14. Sarkar M, Woodland CC, Koren G et al. Pregnancy outcome following gestational exposure to azithromycin. BMC Pregnancy Childbirth 2006; 6: 18.
15. DeMott K. Azithromycin commonly used in International Medical News Group, 2002.
16. Ramsey PS, Vaules MB, Vasdev GM et al. Maternal and transplacental pharmacokinetics of azithromycin. Am J Obstet Gynecol 2003; 188 (3): 714–8.
2. Oakeshott P, Kerry S, Aghaizu A et al. Randomised controlled trial of screening for Chlamydia trachomatis to prevent pelvic inflammatory disease: the POPI (prevention of pelvic infection) trial. BMJ 2010; 340: 1642.
3. Andrews WW, Goldenberg RL, Mercer B et al. The Preterm Prediction Study: association of second-trimester genitourinary Chlamydia infection with subsequent spontaneous preterm birth. Am J Obstet Gynecol 2000; 183: 662–8.
4. Baud D, Regan L, Greub G. Emerging role of Chlamydia and Chlamydia-like organisms in adverse pregnancy outcomes. Curr Opin Infect Dis 2008; 21: 70–6.
5. Kovacs L, Nagy E, Berbik I et al. The frequency and the role of Chlamydia trachomatis infection in premature labor. Int J Gynaecol Obstet 1998; 62: 47–54.
6. Lanjouw E, Ossewaarde JM, Stary A et al. 2010 European guideline for the management of Chlamydia trachomatis infections. Int J STD AIDS 2010; 21 (11): 729–37.
7. Workowski KA, Berman S. Centers for Disease Control and Prevention (CDC). Sexually Transmitted Diseases Treatment Guidelines, 2010. MMWR Recomm Rep 2010; 59 (RR-12): 1–10.
8. Kacmar J, Cheh E, Montagno A, Peipert JF. A randomized trial of azithromycin versus amoxicillin for the treatment of Chlamydia trachomatis in pregnancy. Infect Dis Obstet Gynecol 2001; 9: 197–202.
9. Jacobson GF, Autry AM, Kirby RS et al. A randomized controlled trial comparing amoxicillin and azithromycin for the treatment of Chlamydia trachomatis in pregnancy. Am J Obstet Gynecol 2001; 184: 1352–4.
10. Pitsouni E, Iavazzo C, Athanasiou S, Falagas ME. Single-dose azithromycin versus erythromycin oramoxicillin for Chlamydia trachomatis infectionduring pregnancy: a meta-analysis of randomizedcontrolled trials. Int J Antimicrob Agents 2007; 30 (3): 213–21.
11. Centers for Disease Control and Prevention. Sexually Transmitted Diseases Treatment Guidelines 2006. MMWR 2006; 55 (№RR-11).
12. Adair CD, Gunter M, Stovall TG et al. Chlamydia in pregnancy: a randomized trial of azithromycin and erythromycin. Obstet Gynecol 1998; 91: 165–8.
13. Heikkinen T, Laine K, Neuvonen PJ et al. The transplacental transfer of the macrolide antibiotics erythromycin, roxithromycin and azithromycin. Br J Obstet Gynocol 2000; 107 (6): 770–5.
14. Sarkar M, Woodland CC, Koren G et al. Pregnancy outcome following gestational exposure to azithromycin. BMC Pregnancy Childbirth 2006; 6: 18.
15. DeMott K. Azithromycin commonly used in International Medical News Group, 2002.
16. Ramsey PS, Vaules MB, Vasdev GM et al. Maternal and transplacental pharmacokinetics of azithromycin. Am J Obstet Gynecol 2003; 188 (3): 714–8.
2. Oakeshott P, Kerry S, Aghaizu A et al. Randomised controlled trial of screening for Chlamydia trachomatis to prevent pelvic inflammatory disease: the POPI (prevention of pelvic infection) trial. BMJ 2010; 340: 1642.
3. Andrews WW, Goldenberg RL, Mercer B et al. The Preterm Prediction Study: association of second-trimester genitourinary Chlamydia infection with subsequent spontaneous preterm birth. Am J Obstet Gynecol 2000; 183: 662–8.
4. Baud D, Regan L, Greub G. Emerging role of Chlamydia and Chlamydia-like organisms in adverse pregnancy outcomes. Curr Opin Infect Dis 2008; 21: 70–6.
5. Kovacs L, Nagy E, Berbik I et al. The frequency and the role of Chlamydia trachomatis infection in premature labor. Int J Gynaecol Obstet 1998; 62: 47–54.
6. Lanjouw E, Ossewaarde JM, Stary A et al. 2010 European guideline for the management of Chlamydia trachomatis infections. Int J STD AIDS 2010; 21 (11): 729–37.
7. Workowski KA, Berman S. Centers for Disease Control and Prevention (CDC). Sexually Transmitted Diseases Treatment Guidelines, 2010. MMWR Recomm Rep 2010; 59 (RR-12): 1–10.
8. Kacmar J, Cheh E, Montagno A, Peipert JF. A randomized trial of azithromycin versus amoxicillin for the treatment of Chlamydia trachomatis in pregnancy. Infect Dis Obstet Gynecol 2001; 9: 197–202.
9. Jacobson GF, Autry AM, Kirby RS et al. A randomized controlled trial comparing amoxicillin and azithromycin for the treatment of Chlamydia trachomatis in pregnancy. Am J Obstet Gynecol 2001; 184: 1352–4.
10. Pitsouni E, Iavazzo C, Athanasiou S, Falagas ME. Single-dose azithromycin versus erythromycin oramoxicillin for Chlamydia trachomatis infectionduring pregnancy: a meta-analysis of randomizedcontrolled trials. Int J Antimicrob Agents 2007; 30 (3): 213–21.
11. Centers for Disease Control and Prevention. Sexually Transmitted Diseases Treatment Guidelines 2006. MMWR 2006; 55 (№RR-11).
12. Adair CD, Gunter M, Stovall TG et al. Chlamydia in pregnancy: a randomized trial of azithromycin and erythromycin. Obstet Gynecol 1998; 91: 165–8.
13. Heikkinen T, Laine K, Neuvonen PJ et al. The transplacental transfer of the macrolide antibiotics erythromycin, roxithromycin and azithromycin. Br J Obstet Gynocol 2000; 107 (6): 770–5.
14. Sarkar M, Woodland CC, Koren G et al. Pregnancy outcome following gestational exposure to azithromycin. BMC Pregnancy Childbirth 2006; 6: 18.
15. DeMott K. Azithromycin commonly used in International Medical News Group, 2002.
16. Ramsey PS, Vaules MB, Vasdev GM et al. Maternal and transplacental pharmacokinetics of azithromycin. Am J Obstet Gynecol 2003; 188 (3): 714–8.
________________________________________________
2. Oakeshott P, Kerry S, Aghaizu A et al. Randomised controlled trial of screening for Chlamydia trachomatis to prevent pelvic inflammatory disease: the POPI (prevention of pelvic infection) trial. BMJ 2010; 340: 1642.
3. Andrews WW, Goldenberg RL, Mercer B et al. The Preterm Prediction Study: association of second-trimester genitourinary Chlamydia infection with subsequent spontaneous preterm birth. Am J Obstet Gynecol 2000; 183: 662–8.
4. Baud D, Regan L, Greub G. Emerging role of Chlamydia and Chlamydia-like organisms in adverse pregnancy outcomes. Curr Opin Infect Dis 2008; 21: 70–6.
5. Kovacs L, Nagy E, Berbik I et al. The frequency and the role of Chlamydia trachomatis infection in premature labor. Int J Gynaecol Obstet 1998; 62: 47–54.
6. Lanjouw E, Ossewaarde JM, Stary A et al. 2010 European guideline for the management of Chlamydia trachomatis infections. Int J STD AIDS 2010; 21 (11): 729–37.
7. Workowski KA, Berman S. Centers for Disease Control and Prevention (CDC). Sexually Transmitted Diseases Treatment Guidelines, 2010. MMWR Recomm Rep 2010; 59 (RR-12): 1–10.
8. Kacmar J, Cheh E, Montagno A, Peipert JF. A randomized trial of azithromycin versus amoxicillin for the treatment of Chlamydia trachomatis in pregnancy. Infect Dis Obstet Gynecol 2001; 9: 197–202.
9. Jacobson GF, Autry AM, Kirby RS et al. A randomized controlled trial comparing amoxicillin and azithromycin for the treatment of Chlamydia trachomatis in pregnancy. Am J Obstet Gynecol 2001; 184: 1352–4.
10. Pitsouni E, Iavazzo C, Athanasiou S, Falagas ME. Single-dose azithromycin versus erythromycin oramoxicillin for Chlamydia trachomatis infectionduring pregnancy: a meta-analysis of randomizedcontrolled trials. Int J Antimicrob Agents 2007; 30 (3): 213–21.
11. Centers for Disease Control and Prevention. Sexually Transmitted Diseases Treatment Guidelines 2006. MMWR 2006; 55 (№RR-11).
12. Adair CD, Gunter M, Stovall TG et al. Chlamydia in pregnancy: a randomized trial of azithromycin and erythromycin. Obstet Gynecol 1998; 91: 165–8.
13. Heikkinen T, Laine K, Neuvonen PJ et al. The transplacental transfer of the macrolide antibiotics erythromycin, roxithromycin and azithromycin. Br J Obstet Gynocol 2000; 107 (6): 770–5.
14. Sarkar M, Woodland CC, Koren G et al. Pregnancy outcome following gestational exposure to azithromycin. BMC Pregnancy Childbirth 2006; 6: 18.
15. DeMott K. Azithromycin commonly used in International Medical News Group, 2002.
16. Ramsey PS, Vaules MB, Vasdev GM et al. Maternal and transplacental pharmacokinetics of azithromycin. Am J Obstet Gynecol 2003; 188 (3): 714–8.
Авторы
Н.Н.Володин1, Э.К.Айламазян2, А.Д.Макацария3, В.Н.Кузьмин4
1. Российская ассоциация специалистов перинатальной медицины, Москва;
2. ФГБУ Научно-исследовательский институт акушерства и гинекологии им. Д.О.Отта, Санкт-Петербург;
3. ГБОУ ВПО Первый МГМУ им. И.М.Сеченова Минздрава РФ;
4. ГБОУ ВПО МГМСУ им. А.И.Евдокимова Минздрава РФ
1. Российская ассоциация специалистов перинатальной медицины, Москва;
2. ФГБУ Научно-исследовательский институт акушерства и гинекологии им. Д.О.Отта, Санкт-Петербург;
3. ГБОУ ВПО Первый МГМУ им. И.М.Сеченова Минздрава РФ;
4. ГБОУ ВПО МГМСУ им. А.И.Евдокимова Минздрава РФ
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