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Мировой опыт использования пиридоксина: экспериментальная и клиническая база применения в акушерско-гинекологической практике
Мировой опыт использования пиридоксина: экспериментальная и клиническая база применения в акушерско-гинекологической практике
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Аннотация
Разные формы витамина В6 (пиридоксин, пиридоксаль, пиридоксаль фосфат) являются эндогенными кофакторами более 100 ферментов организма человека. Влияние пиридоксина и других форм витамина В6 на эти ферменты обусловливает его участие в широком круге метаболических процессов. Витамин В6 также считается фармакокинетическим и фармакодинамическим синергистом магния. К настоящему времени в базах данных научных публикаций по биомедицине имеется более 10 тыс. исследований по молекулярным, экспериментальным и клиническим эффектам пиридоксина и других витамеров В6. В настоящем исследовании проведен систематический анализ этого значительного массива публикаций на основании современных алгоритмов поиска научной информации. Имеющаяся доказательная база позволяет утверждать, что применение препаратов пиридоксина в сочетании с магнием перспективно для поддержки функции почек, сохранения структуры костей, снижения воспаления, онкопротекции, при депрессии и предменструальном синдроме, а также для профилактики диабета и сердечно-сосудистой патологии. Исследования указывают на высокую безопасность применения пиридоксина как в общей, так и в акушерско-гинекологической практике.
Ключевые слова: пиридоксин, доказательная медицина, акушерство и гинекология, нефропротекция, кардиопротекция, противовоспалительный эффект.
Key words: pyridoxine, evidence-based medicine, obstetrics and gynecology, nephroprotection, cardioprotection, anti-inflammatory effect.
Ключевые слова: пиридоксин, доказательная медицина, акушерство и гинекология, нефропротекция, кардиопротекция, противовоспалительный эффект.
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Key words: pyridoxine, evidence-based medicine, obstetrics and gynecology, nephroprotection, cardioprotection, anti-inflammatory effect.
Полный текст
Список литературы
1. Kant AK, Block G. Dietary vitamin B-6 intake and food sources in the US population: NHANES II, 1976–1980. Am J Clin Nutr 1990; 52 (4): 707–16.
2. Bercovici JP, Mabin D. Vitamin B 6 deficiency following the taking of estrogens. Nouv Presse Med 1977; 6 (27): 2439.
3. Громова О.А. Магний и пиридоксин: основы знаний. М.: ПротоТип, 2006.
4. Торшин И.Ю., Громова О.А. 25 мгновений молекулярной фармакологии. М.: А-Гриф, 2012.
5. Ravichandran V, Selvam R. Increased lipid peroxidation in kidney of vitamin B-6 deficient rats. Biochem Int 1990; 21 (4): 599–605.
6. Wolfson M, Cohen AH, Kopple JD. Vitamin B-6 deficiency and renal function and structure in chronically uremic rats. Am J Clin Nutr 1991; 53 (4): 935–42.
7. Федеральное руководство по использованию лекарственных средств. М.: ГЕОТАР-МЕД, 2012.
8. Corken M, Porter J. Is vitamin B(6) deficiency an under-recognized risk in patients receiving haemodialysis? A systematic review: 2000–2010. Nephrology (Carlton) 2011; 16 (7): 619–25.
9. Scheinman JI, Voziyan PA, Belmont JM et al. Pyridoxamine lowers oxalate excretion and kidney crystals in experimental hyperoxaluria: a potential therapy for primary hyperoxaluria. Urol Res 2005; 33 (5): 368–71.
10. Chetyrkin SV, Kim D, Belmont JM et al. Pyridoxamine lowers kidney crystals in experimental hyperoxaluria: a potential therapy for primary hyperoxaluria. Kidney Int 2005; 67 (1): 53–60.
11. Li S, Wu C, Nong H, Deng Y. Morphometrical study on inhibitory effect of vitamin B6 and banana-stem extract on calcium crystallization. Zhonghua Wai Ke Za Zhi 1998; 36 (12): 763–5.
12. Curhan GC, Willett WC, Speizer FE, Stampfer MJ. Intake of vitamins B6 and C and the risk of kidney stones in women. J Am Soc Nephrol 1999; 10 (4): 840–5.
13. Dubick MA, Gretz D, Majumdar AP. Overt vitamin B-6 deficiency affects rat pancreatic digestive enzyme and glutathione reductase activities. J Nutr 1995; 125 (1): 20–5.
14. Hou CT, Wu YH, Huang PN et al. Higher plasma pyridoxal 5'-phosphate is associated with better blood glucose responses in critically ill surgical patients with inadequate vitamin B-6 status. Clin Nutr 2011; 30 (4): 478–83.
15. Ahn HJ, Min KW, Cho YO. Assessment of vitamin B(6) status in Korean patients with newly diagnosed type 2 diabetes. Nutr Res Pract 2011; 5 (1): 34–9. Epub 2011.
16. Shen J, Lai CQ, Mattei J et al. Association of vitamin B-6 status with inflammation, oxidative stress, and chronic inflammatory conditions: the Boston Puerto Rican Health Study. Am J Clin Nutr 2010; 91 (2): 337–42. Epub 2009.
17. Меховская Л.Ю. Питание беременных Кузбасса: гигиеническая оценка его влияния на течение беременности, состояние внутриутробного плода. Автореф. дис. ... канд. мед. наук. Иркутск, 2006.
18. Torshin I.Yu., Gromova O.A. Magnesium and pyridoxine: fundamental studies and clinical practice. Nova Science, NY, 2011.
19. Holstein JH, Herrmann M, Splett C et al. Low serum folate and vitamin B-6 are associated with an altered cancellous bone structure in humans. Am J Clin Nutr 2009; 90 (5): 1440–5.
20. Громова О.А., Торшин И.Ю., Керимкулова Н.В. и др. Дефицит магния как патогенетический фактор остеопороза, остеопении и рахита. Систематический анализ молекулярных и клинических исследований. Методические рекомендации для врачей. Под ред. В.Н.Серова. М., 2012.
21. Morris MS, Sakakeeny L, Jacques PF et al. Vitamin B-6 intake is inversely related to, and the requirement is affected by, inflammation status. J Nutr 2010; 140 (1): 103–10.
22. Ambrosch A, Dierkes J, Lobmann R et al. Relation between homocysteinaemia and diabetic neuropathy in patients with Type 2 diabetes mellitus. Diabet Med 2001; 18 (3): 185–92.
23. Martinez M, Cuskelly GJ, Williamson J et al. Vitamin B-6 deficiency in rats reduces hepatic serine hydroxymethyltransferase and cystathionine beta-synthase activities and rates of in vivo protein turnover, homocysteine remethylation and transsulfuration. J Nutr 2000; 130 (5): 1115–23.
24. Chacko SA, Song Y, Nathan L et al. Relations of dietary magnesium intake to biomarkers of inflammation and endothelial dysfunction in an ethnically diverse cohort of postmenopausal women. Diabetes Care 2010; 33 (2): 304–10.
25. De Oliveira Otto MC, Alonso A, Lee DH et al. Dietary micronutrient intakes are associated with markers of inflammation but not with markers of subclinical atherosclerosis. J Nutr 2011; 141 (8): 1508–15.
26. Midttun O, Hustad S, Schneede J et al. Plasma vitamin B-6 forms and their relation to transsulfuration metabolites in a large, population-based study. Am J Clin Nutr 2007; 86 (1): 131–8.
27. McKinley MC, McNulty H, McPartlin J et al. Low-dose vitamin B-6 effectively lowers fasting plasma homocysteine in healthy elderly persons who are folate and riboflavin replete. Am J Clin Nutr 2001; 73 (4): 759–64.
28. Meydani SN, Ribaya-Mercado JD. Vitamin B-6 deficiency impairs interleukin 2 production and lymphocyte proliferation in elderly adults. Am J Clin Nutr 1991; 53 (5): 1275–80.
29. Chiang EP, Bagley PJ, Selhub J et al. Abnormal vitamin B(6) status is associated with severity of symptoms in patients with rheumatoid arthritis. Am J Med 2003; 114 (4): 283–7.
30. Huang SC, Wei JC, Wu DJ, Huang YC. Vitamin B(6) supplementation improves pro-inflammatory responses in patients with rheumatoid arthritis. Eur J Clin Nutr 2010; 64 (9): 1007.
31. Громова О.А., Торшин И.Ю., Баранов А.А. и др. Роль различных форм омега-3 полиненасыщенных жирных кислот в акушерстве и неонатологии. Методические рекомендации для врачей. Рос. общество акушеров-гинекологов, 2012.
32. Van Wijk N, Watkins CJ, Hageman RJ et al. Combined dietary folate, vitamin B-12, and vitamin B-6 intake influences plasma docosahexaenoic acid concentration in rats. Nutr Metab (Lond) 2012; 9 (1): 49.
33. Harris HR, Cramer DW, Vitonis AF et al. Folate, vitamin B(6), vitamin B(12), methionine and alcohol intake in relation to ovarian cancer risk. Int J Cancer 2012; 131 (4): E518–29.
34. Chou YC, Chu CH, Wu MH et al. Dietary intake of vitamin B(6) and risk of breast cancer in Taiwanese women. J Epidemiol 2011; 21 (5): 329–36 doi.
35. Ishihara J, Otani T, Inoue M et al. Low intake of vitamin B-6 is associated with increased risk of colorectal cancer in Japanese men. J Nutr 2007; 137 (7): 1808–14.
36. Wyatt KM, Dimmock PW, Jones PW, Shaughn O'Brien PM. Efficacy of vitamin B-6 in the treatment of premenstrual syndrome: systematic review. BMJ 1999; 318 (7195): 1375–81.
37. Bibi S, Qureshi F, Ahmad M et al. Hyperhomocysteinaemia, vascular related pregnancy complications and the response to vitamin supplementation in pregnant women of Pakistan. J Pak Med Assoc 2010; 60 (9): 741–5.
38. Munger RG, Sauberlich HE, Corcoran C et al. Maternal vitamin B-6 and folate status and risk of oral cleft birth defects in the Philippines. Birth Defects Res A Clin Mol Teratol 2004; 70 (7): 464–71.
39. Толмачева С.М. Индивидуальные методы профилактики кариеса зубов и болезней пародонта у беременных женщин. Автореф. дис. ... канд. мед. наук. 2004.
40. Mahomed K, Gulmezoglu AM. Pyridoxine (vitamin B6) supplementation in pregnancy. Cochrane Database Syst Rev 2000; 2: CD000179.
41. Hillman RW, Cabaud PG, Schenone RA. The effects of pyridoxine supplements on the dental caries experience of pregnant women. Am J Clin Nutr 1962; 10: 512–5.
42. Jewell D, Young G. Interventions for nausea and vomiting in early pregnancy. Cochrane Database Syst Rev 2003; 4: CD000145.
43. Нормы физиологических потребностей в энергии и пищевых веществах для различных групп населения Российской Федерации, 2008. Методические рекомендации 2.3.1.2432-08.
44. Antopol W, Thomas M. Experimental study of the effects produced by large doses of vitamin B6. J Neuropathol Exp Neurol 1942; 1: 330–6.
45. Schaeppi U, Krinke G. Pyridoxine neuropathy: correlation of functional tests and neuropathology in beagle dogs treated with large doses of vita- min B6. Agents Actions 1982; 12: 575–82.
46. Krinke G, Naylor DC, Skorpil V. Pyridoxine megavitaminosis: an analysis of the early changes induced with massive doses of vitamin B6 in rat primary sensory neurons. J. Neuropathol Exp Neurol 1985; 44: 117–29.
47. Schaumburg HH, Kaplan J, Windebank AJ et al. Sensory neuropathy from pyridoxine abuse: a new megavitamin syndrome. N Eng J Med 1983; 309: 445–8.
48. Malmgren R, Collins A, Nilsson CG. Platelet serotonin uptake and effects of vitamin B6-treatment in premenstrual tension. Neuropsychobiology 1987; 18: 83–6.
2. Bercovici JP, Mabin D. Vitamin B 6 deficiency following the taking of estrogens. Nouv Presse Med 1977; 6 (27): 2439.
3. Громова О.А. Магний и пиридоксин: основы знаний. М.: ПротоТип, 2006.
4. Торшин И.Ю., Громова О.А. 25 мгновений молекулярной фармакологии. М.: А-Гриф, 2012.
5. Ravichandran V, Selvam R. Increased lipid peroxidation in kidney of vitamin B-6 deficient rats. Biochem Int 1990; 21 (4): 599–605.
6. Wolfson M, Cohen AH, Kopple JD. Vitamin B-6 deficiency and renal function and structure in chronically uremic rats. Am J Clin Nutr 1991; 53 (4): 935–42.
7. Федеральное руководство по использованию лекарственных средств. М.: ГЕОТАР-МЕД, 2012.
8. Corken M, Porter J. Is vitamin B(6) deficiency an under-recognized risk in patients receiving haemodialysis? A systematic review: 2000–2010. Nephrology (Carlton) 2011; 16 (7): 619–25.
9. Scheinman JI, Voziyan PA, Belmont JM et al. Pyridoxamine lowers oxalate excretion and kidney crystals in experimental hyperoxaluria: a potential therapy for primary hyperoxaluria. Urol Res 2005; 33 (5): 368–71.
10. Chetyrkin SV, Kim D, Belmont JM et al. Pyridoxamine lowers kidney crystals in experimental hyperoxaluria: a potential therapy for primary hyperoxaluria. Kidney Int 2005; 67 (1): 53–60.
11. Li S, Wu C, Nong H, Deng Y. Morphometrical study on inhibitory effect of vitamin B6 and banana-stem extract on calcium crystallization. Zhonghua Wai Ke Za Zhi 1998; 36 (12): 763–5.
12. Curhan GC, Willett WC, Speizer FE, Stampfer MJ. Intake of vitamins B6 and C and the risk of kidney stones in women. J Am Soc Nephrol 1999; 10 (4): 840–5.
13. Dubick MA, Gretz D, Majumdar AP. Overt vitamin B-6 deficiency affects rat pancreatic digestive enzyme and glutathione reductase activities. J Nutr 1995; 125 (1): 20–5.
14. Hou CT, Wu YH, Huang PN et al. Higher plasma pyridoxal 5'-phosphate is associated with better blood glucose responses in critically ill surgical patients with inadequate vitamin B-6 status. Clin Nutr 2011; 30 (4): 478–83.
15. Ahn HJ, Min KW, Cho YO. Assessment of vitamin B(6) status in Korean patients with newly diagnosed type 2 diabetes. Nutr Res Pract 2011; 5 (1): 34–9. Epub 2011.
16. Shen J, Lai CQ, Mattei J et al. Association of vitamin B-6 status with inflammation, oxidative stress, and chronic inflammatory conditions: the Boston Puerto Rican Health Study. Am J Clin Nutr 2010; 91 (2): 337–42. Epub 2009.
17. Меховская Л.Ю. Питание беременных Кузбасса: гигиеническая оценка его влияния на течение беременности, состояние внутриутробного плода. Автореф. дис. ... канд. мед. наук. Иркутск, 2006.
18. Torshin I.Yu., Gromova O.A. Magnesium and pyridoxine: fundamental studies and clinical practice. Nova Science, NY, 2011.
19. Holstein JH, Herrmann M, Splett C et al. Low serum folate and vitamin B-6 are associated with an altered cancellous bone structure in humans. Am J Clin Nutr 2009; 90 (5): 1440–5.
20. Громова О.А., Торшин И.Ю., Керимкулова Н.В. и др. Дефицит магния как патогенетический фактор остеопороза, остеопении и рахита. Систематический анализ молекулярных и клинических исследований. Методические рекомендации для врачей. Под ред. В.Н.Серова. М., 2012.
21. Morris MS, Sakakeeny L, Jacques PF et al. Vitamin B-6 intake is inversely related to, and the requirement is affected by, inflammation status. J Nutr 2010; 140 (1): 103–10.
22. Ambrosch A, Dierkes J, Lobmann R et al. Relation between homocysteinaemia and diabetic neuropathy in patients with Type 2 diabetes mellitus. Diabet Med 2001; 18 (3): 185–92.
23. Martinez M, Cuskelly GJ, Williamson J et al. Vitamin B-6 deficiency in rats reduces hepatic serine hydroxymethyltransferase and cystathionine beta-synthase activities and rates of in vivo protein turnover, homocysteine remethylation and transsulfuration. J Nutr 2000; 130 (5): 1115–23.
24. Chacko SA, Song Y, Nathan L et al. Relations of dietary magnesium intake to biomarkers of inflammation and endothelial dysfunction in an ethnically diverse cohort of postmenopausal women. Diabetes Care 2010; 33 (2): 304–10.
25. De Oliveira Otto MC, Alonso A, Lee DH et al. Dietary micronutrient intakes are associated with markers of inflammation but not with markers of subclinical atherosclerosis. J Nutr 2011; 141 (8): 1508–15.
26. Midttun O, Hustad S, Schneede J et al. Plasma vitamin B-6 forms and their relation to transsulfuration metabolites in a large, population-based study. Am J Clin Nutr 2007; 86 (1): 131–8.
27. McKinley MC, McNulty H, McPartlin J et al. Low-dose vitamin B-6 effectively lowers fasting plasma homocysteine in healthy elderly persons who are folate and riboflavin replete. Am J Clin Nutr 2001; 73 (4): 759–64.
28. Meydani SN, Ribaya-Mercado JD. Vitamin B-6 deficiency impairs interleukin 2 production and lymphocyte proliferation in elderly adults. Am J Clin Nutr 1991; 53 (5): 1275–80.
29. Chiang EP, Bagley PJ, Selhub J et al. Abnormal vitamin B(6) status is associated with severity of symptoms in patients with rheumatoid arthritis. Am J Med 2003; 114 (4): 283–7.
30. Huang SC, Wei JC, Wu DJ, Huang YC. Vitamin B(6) supplementation improves pro-inflammatory responses in patients with rheumatoid arthritis. Eur J Clin Nutr 2010; 64 (9): 1007.
31. Громова О.А., Торшин И.Ю., Баранов А.А. и др. Роль различных форм омега-3 полиненасыщенных жирных кислот в акушерстве и неонатологии. Методические рекомендации для врачей. Рос. общество акушеров-гинекологов, 2012.
32. Van Wijk N, Watkins CJ, Hageman RJ et al. Combined dietary folate, vitamin B-12, and vitamin B-6 intake influences plasma docosahexaenoic acid concentration in rats. Nutr Metab (Lond) 2012; 9 (1): 49.
33. Harris HR, Cramer DW, Vitonis AF et al. Folate, vitamin B(6), vitamin B(12), methionine and alcohol intake in relation to ovarian cancer risk. Int J Cancer 2012; 131 (4): E518–29.
34. Chou YC, Chu CH, Wu MH et al. Dietary intake of vitamin B(6) and risk of breast cancer in Taiwanese women. J Epidemiol 2011; 21 (5): 329–36 doi.
35. Ishihara J, Otani T, Inoue M et al. Low intake of vitamin B-6 is associated with increased risk of colorectal cancer in Japanese men. J Nutr 2007; 137 (7): 1808–14.
36. Wyatt KM, Dimmock PW, Jones PW, Shaughn O'Brien PM. Efficacy of vitamin B-6 in the treatment of premenstrual syndrome: systematic review. BMJ 1999; 318 (7195): 1375–81.
37. Bibi S, Qureshi F, Ahmad M et al. Hyperhomocysteinaemia, vascular related pregnancy complications and the response to vitamin supplementation in pregnant women of Pakistan. J Pak Med Assoc 2010; 60 (9): 741–5.
38. Munger RG, Sauberlich HE, Corcoran C et al. Maternal vitamin B-6 and folate status and risk of oral cleft birth defects in the Philippines. Birth Defects Res A Clin Mol Teratol 2004; 70 (7): 464–71.
39. Толмачева С.М. Индивидуальные методы профилактики кариеса зубов и болезней пародонта у беременных женщин. Автореф. дис. ... канд. мед. наук. 2004.
40. Mahomed K, Gulmezoglu AM. Pyridoxine (vitamin B6) supplementation in pregnancy. Cochrane Database Syst Rev 2000; 2: CD000179.
41. Hillman RW, Cabaud PG, Schenone RA. The effects of pyridoxine supplements on the dental caries experience of pregnant women. Am J Clin Nutr 1962; 10: 512–5.
42. Jewell D, Young G. Interventions for nausea and vomiting in early pregnancy. Cochrane Database Syst Rev 2003; 4: CD000145.
43. Нормы физиологических потребностей в энергии и пищевых веществах для различных групп населения Российской Федерации, 2008. Методические рекомендации 2.3.1.2432-08.
44. Antopol W, Thomas M. Experimental study of the effects produced by large doses of vitamin B6. J Neuropathol Exp Neurol 1942; 1: 330–6.
45. Schaeppi U, Krinke G. Pyridoxine neuropathy: correlation of functional tests and neuropathology in beagle dogs treated with large doses of vita- min B6. Agents Actions 1982; 12: 575–82.
46. Krinke G, Naylor DC, Skorpil V. Pyridoxine megavitaminosis: an analysis of the early changes induced with massive doses of vitamin B6 in rat primary sensory neurons. J. Neuropathol Exp Neurol 1985; 44: 117–29.
47. Schaumburg HH, Kaplan J, Windebank AJ et al. Sensory neuropathy from pyridoxine abuse: a new megavitamin syndrome. N Eng J Med 1983; 309: 445–8.
48. Malmgren R, Collins A, Nilsson CG. Platelet serotonin uptake and effects of vitamin B6-treatment in premenstrual tension. Neuropsychobiology 1987; 18: 83–6.
2. Bercovici JP, Mabin D. Vitamin B 6 deficiency following the taking of estrogens. Nouv Presse Med 1977; 6 (27): 2439.
3. Громова О.А. Магний и пиридоксин: основы знаний. М.: ПротоТип, 2006.
4. Торшин И.Ю., Громова О.А. 25 мгновений молекулярной фармакологии. М.: А-Гриф, 2012.
5. Ravichandran V, Selvam R. Increased lipid peroxidation in kidney of vitamin B-6 deficient rats. Biochem Int 1990; 21 (4): 599–605.
6. Wolfson M, Cohen AH, Kopple JD. Vitamin B-6 deficiency and renal function and structure in chronically uremic rats. Am J Clin Nutr 1991; 53 (4): 935–42.
7. Федеральное руководство по использованию лекарственных средств. М.: ГЕОТАР-МЕД, 2012.
8. Corken M, Porter J. Is vitamin B(6) deficiency an under-recognized risk in patients receiving haemodialysis? A systematic review: 2000–2010. Nephrology (Carlton) 2011; 16 (7): 619–25.
9. Scheinman JI, Voziyan PA, Belmont JM et al. Pyridoxamine lowers oxalate excretion and kidney crystals in experimental hyperoxaluria: a potential therapy for primary hyperoxaluria. Urol Res 2005; 33 (5): 368–71.
10. Chetyrkin SV, Kim D, Belmont JM et al. Pyridoxamine lowers kidney crystals in experimental hyperoxaluria: a potential therapy for primary hyperoxaluria. Kidney Int 2005; 67 (1): 53–60.
11. Li S, Wu C, Nong H, Deng Y. Morphometrical study on inhibitory effect of vitamin B6 and banana-stem extract on calcium crystallization. Zhonghua Wai Ke Za Zhi 1998; 36 (12): 763–5.
12. Curhan GC, Willett WC, Speizer FE, Stampfer MJ. Intake of vitamins B6 and C and the risk of kidney stones in women. J Am Soc Nephrol 1999; 10 (4): 840–5.
13. Dubick MA, Gretz D, Majumdar AP. Overt vitamin B-6 deficiency affects rat pancreatic digestive enzyme and glutathione reductase activities. J Nutr 1995; 125 (1): 20–5.
14. Hou CT, Wu YH, Huang PN et al. Higher plasma pyridoxal 5'-phosphate is associated with better blood glucose responses in critically ill surgical patients with inadequate vitamin B-6 status. Clin Nutr 2011; 30 (4): 478–83.
15. Ahn HJ, Min KW, Cho YO. Assessment of vitamin B(6) status in Korean patients with newly diagnosed type 2 diabetes. Nutr Res Pract 2011; 5 (1): 34–9. Epub 2011.
16. Shen J, Lai CQ, Mattei J et al. Association of vitamin B-6 status with inflammation, oxidative stress, and chronic inflammatory conditions: the Boston Puerto Rican Health Study. Am J Clin Nutr 2010; 91 (2): 337–42. Epub 2009.
17. Меховская Л.Ю. Питание беременных Кузбасса: гигиеническая оценка его влияния на течение беременности, состояние внутриутробного плода. Автореф. дис. ... канд. мед. наук. Иркутск, 2006.
18. Torshin I.Yu., Gromova O.A. Magnesium and pyridoxine: fundamental studies and clinical practice. Nova Science, NY, 2011.
19. Holstein JH, Herrmann M, Splett C et al. Low serum folate and vitamin B-6 are associated with an altered cancellous bone structure in humans. Am J Clin Nutr 2009; 90 (5): 1440–5.
20. Громова О.А., Торшин И.Ю., Керимкулова Н.В. и др. Дефицит магния как патогенетический фактор остеопороза, остеопении и рахита. Систематический анализ молекулярных и клинических исследований. Методические рекомендации для врачей. Под ред. В.Н.Серова. М., 2012.
21. Morris MS, Sakakeeny L, Jacques PF et al. Vitamin B-6 intake is inversely related to, and the requirement is affected by, inflammation status. J Nutr 2010; 140 (1): 103–10.
22. Ambrosch A, Dierkes J, Lobmann R et al. Relation between homocysteinaemia and diabetic neuropathy in patients with Type 2 diabetes mellitus. Diabet Med 2001; 18 (3): 185–92.
23. Martinez M, Cuskelly GJ, Williamson J et al. Vitamin B-6 deficiency in rats reduces hepatic serine hydroxymethyltransferase and cystathionine beta-synthase activities and rates of in vivo protein turnover, homocysteine remethylation and transsulfuration. J Nutr 2000; 130 (5): 1115–23.
24. Chacko SA, Song Y, Nathan L et al. Relations of dietary magnesium intake to biomarkers of inflammation and endothelial dysfunction in an ethnically diverse cohort of postmenopausal women. Diabetes Care 2010; 33 (2): 304–10.
25. De Oliveira Otto MC, Alonso A, Lee DH et al. Dietary micronutrient intakes are associated with markers of inflammation but not with markers of subclinical atherosclerosis. J Nutr 2011; 141 (8): 1508–15.
26. Midttun O, Hustad S, Schneede J et al. Plasma vitamin B-6 forms and their relation to transsulfuration metabolites in a large, population-based study. Am J Clin Nutr 2007; 86 (1): 131–8.
27. McKinley MC, McNulty H, McPartlin J et al. Low-dose vitamin B-6 effectively lowers fasting plasma homocysteine in healthy elderly persons who are folate and riboflavin replete. Am J Clin Nutr 2001; 73 (4): 759–64.
28. Meydani SN, Ribaya-Mercado JD. Vitamin B-6 deficiency impairs interleukin 2 production and lymphocyte proliferation in elderly adults. Am J Clin Nutr 1991; 53 (5): 1275–80.
29. Chiang EP, Bagley PJ, Selhub J et al. Abnormal vitamin B(6) status is associated with severity of symptoms in patients with rheumatoid arthritis. Am J Med 2003; 114 (4): 283–7.
30. Huang SC, Wei JC, Wu DJ, Huang YC. Vitamin B(6) supplementation improves pro-inflammatory responses in patients with rheumatoid arthritis. Eur J Clin Nutr 2010; 64 (9): 1007.
31. Громова О.А., Торшин И.Ю., Баранов А.А. и др. Роль различных форм омега-3 полиненасыщенных жирных кислот в акушерстве и неонатологии. Методические рекомендации для врачей. Рос. общество акушеров-гинекологов, 2012.
32. Van Wijk N, Watkins CJ, Hageman RJ et al. Combined dietary folate, vitamin B-12, and vitamin B-6 intake influences plasma docosahexaenoic acid concentration in rats. Nutr Metab (Lond) 2012; 9 (1): 49.
33. Harris HR, Cramer DW, Vitonis AF et al. Folate, vitamin B(6), vitamin B(12), methionine and alcohol intake in relation to ovarian cancer risk. Int J Cancer 2012; 131 (4): E518–29.
34. Chou YC, Chu CH, Wu MH et al. Dietary intake of vitamin B(6) and risk of breast cancer in Taiwanese women. J Epidemiol 2011; 21 (5): 329–36 doi.
35. Ishihara J, Otani T, Inoue M et al. Low intake of vitamin B-6 is associated with increased risk of colorectal cancer in Japanese men. J Nutr 2007; 137 (7): 1808–14.
36. Wyatt KM, Dimmock PW, Jones PW, Shaughn O'Brien PM. Efficacy of vitamin B-6 in the treatment of premenstrual syndrome: systematic review. BMJ 1999; 318 (7195): 1375–81.
37. Bibi S, Qureshi F, Ahmad M et al. Hyperhomocysteinaemia, vascular related pregnancy complications and the response to vitamin supplementation in pregnant women of Pakistan. J Pak Med Assoc 2010; 60 (9): 741–5.
38. Munger RG, Sauberlich HE, Corcoran C et al. Maternal vitamin B-6 and folate status and risk of oral cleft birth defects in the Philippines. Birth Defects Res A Clin Mol Teratol 2004; 70 (7): 464–71.
39. Толмачева С.М. Индивидуальные методы профилактики кариеса зубов и болезней пародонта у беременных женщин. Автореф. дис. ... канд. мед. наук. 2004.
40. Mahomed K, Gulmezoglu AM. Pyridoxine (vitamin B6) supplementation in pregnancy. Cochrane Database Syst Rev 2000; 2: CD000179.
41. Hillman RW, Cabaud PG, Schenone RA. The effects of pyridoxine supplements on the dental caries experience of pregnant women. Am J Clin Nutr 1962; 10: 512–5.
42. Jewell D, Young G. Interventions for nausea and vomiting in early pregnancy. Cochrane Database Syst Rev 2003; 4: CD000145.
43. Нормы физиологических потребностей в энергии и пищевых веществах для различных групп населения Российской Федерации, 2008. Методические рекомендации 2.3.1.2432-08.
44. Antopol W, Thomas M. Experimental study of the effects produced by large doses of vitamin B6. J Neuropathol Exp Neurol 1942; 1: 330–6.
45. Schaeppi U, Krinke G. Pyridoxine neuropathy: correlation of functional tests and neuropathology in beagle dogs treated with large doses of vita- min B6. Agents Actions 1982; 12: 575–82.
46. Krinke G, Naylor DC, Skorpil V. Pyridoxine megavitaminosis: an analysis of the early changes induced with massive doses of vitamin B6 in rat primary sensory neurons. J. Neuropathol Exp Neurol 1985; 44: 117–29.
47. Schaumburg HH, Kaplan J, Windebank AJ et al. Sensory neuropathy from pyridoxine abuse: a new megavitamin syndrome. N Eng J Med 1983; 309: 445–8.
48. Malmgren R, Collins A, Nilsson CG. Platelet serotonin uptake and effects of vitamin B6-treatment in premenstrual tension. Neuropsychobiology 1987; 18: 83–6.
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17. Меховская Л.Ю. Питание беременных Кузбасса: гигиеническая оценка его влияния на течение беременности, состояние внутриутробного плода. Автореф. дис. ... канд. мед. наук. Иркутск, 2006.
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19. Holstein JH, Herrmann M, Splett C et al. Low serum folate and vitamin B-6 are associated with an altered cancellous bone structure in humans. Am J Clin Nutr 2009; 90 (5): 1440–5.
20. Громова О.А., Торшин И.Ю., Керимкулова Н.В. и др. Дефицит магния как патогенетический фактор остеопороза, остеопении и рахита. Систематический анализ молекулярных и клинических исследований. Методические рекомендации для врачей. Под ред. В.Н.Серова. М., 2012.
21. Morris MS, Sakakeeny L, Jacques PF et al. Vitamin B-6 intake is inversely related to, and the requirement is affected by, inflammation status. J Nutr 2010; 140 (1): 103–10.
22. Ambrosch A, Dierkes J, Lobmann R et al. Relation between homocysteinaemia and diabetic neuropathy in patients with Type 2 diabetes mellitus. Diabet Med 2001; 18 (3): 185–92.
23. Martinez M, Cuskelly GJ, Williamson J et al. Vitamin B-6 deficiency in rats reduces hepatic serine hydroxymethyltransferase and cystathionine beta-synthase activities and rates of in vivo protein turnover, homocysteine remethylation and transsulfuration. J Nutr 2000; 130 (5): 1115–23.
24. Chacko SA, Song Y, Nathan L et al. Relations of dietary magnesium intake to biomarkers of inflammation and endothelial dysfunction in an ethnically diverse cohort of postmenopausal women. Diabetes Care 2010; 33 (2): 304–10.
25. De Oliveira Otto MC, Alonso A, Lee DH et al. Dietary micronutrient intakes are associated with markers of inflammation but not with markers of subclinical atherosclerosis. J Nutr 2011; 141 (8): 1508–15.
26. Midttun O, Hustad S, Schneede J et al. Plasma vitamin B-6 forms and their relation to transsulfuration metabolites in a large, population-based study. Am J Clin Nutr 2007; 86 (1): 131–8.
27. McKinley MC, McNulty H, McPartlin J et al. Low-dose vitamin B-6 effectively lowers fasting plasma homocysteine in healthy elderly persons who are folate and riboflavin replete. Am J Clin Nutr 2001; 73 (4): 759–64.
28. Meydani SN, Ribaya-Mercado JD. Vitamin B-6 deficiency impairs interleukin 2 production and lymphocyte proliferation in elderly adults. Am J Clin Nutr 1991; 53 (5): 1275–80.
29. Chiang EP, Bagley PJ, Selhub J et al. Abnormal vitamin B(6) status is associated with severity of symptoms in patients with rheumatoid arthritis. Am J Med 2003; 114 (4): 283–7.
30. Huang SC, Wei JC, Wu DJ, Huang YC. Vitamin B(6) supplementation improves pro-inflammatory responses in patients with rheumatoid arthritis. Eur J Clin Nutr 2010; 64 (9): 1007.
31. Громова О.А., Торшин И.Ю., Баранов А.А. и др. Роль различных форм омега-3 полиненасыщенных жирных кислот в акушерстве и неонатологии. Методические рекомендации для врачей. Рос. общество акушеров-гинекологов, 2012.
32. Van Wijk N, Watkins CJ, Hageman RJ et al. Combined dietary folate, vitamin B-12, and vitamin B-6 intake influences plasma docosahexaenoic acid concentration in rats. Nutr Metab (Lond) 2012; 9 (1): 49.
33. Harris HR, Cramer DW, Vitonis AF et al. Folate, vitamin B(6), vitamin B(12), methionine and alcohol intake in relation to ovarian cancer risk. Int J Cancer 2012; 131 (4): E518–29.
34. Chou YC, Chu CH, Wu MH et al. Dietary intake of vitamin B(6) and risk of breast cancer in Taiwanese women. J Epidemiol 2011; 21 (5): 329–36 doi.
35. Ishihara J, Otani T, Inoue M et al. Low intake of vitamin B-6 is associated with increased risk of colorectal cancer in Japanese men. J Nutr 2007; 137 (7): 1808–14.
36. Wyatt KM, Dimmock PW, Jones PW, Shaughn O'Brien PM. Efficacy of vitamin B-6 in the treatment of premenstrual syndrome: systematic review. BMJ 1999; 318 (7195): 1375–81.
37. Bibi S, Qureshi F, Ahmad M et al. Hyperhomocysteinaemia, vascular related pregnancy complications and the response to vitamin supplementation in pregnant women of Pakistan. J Pak Med Assoc 2010; 60 (9): 741–5.
38. Munger RG, Sauberlich HE, Corcoran C et al. Maternal vitamin B-6 and folate status and risk of oral cleft birth defects in the Philippines. Birth Defects Res A Clin Mol Teratol 2004; 70 (7): 464–71.
39. Толмачева С.М. Индивидуальные методы профилактики кариеса зубов и болезней пародонта у беременных женщин. Автореф. дис. ... канд. мед. наук. 2004.
40. Mahomed K, Gulmezoglu AM. Pyridoxine (vitamin B6) supplementation in pregnancy. Cochrane Database Syst Rev 2000; 2: CD000179.
41. Hillman RW, Cabaud PG, Schenone RA. The effects of pyridoxine supplements on the dental caries experience of pregnant women. Am J Clin Nutr 1962; 10: 512–5.
42. Jewell D, Young G. Interventions for nausea and vomiting in early pregnancy. Cochrane Database Syst Rev 2003; 4: CD000145.
43. Нормы физиологических потребностей в энергии и пищевых веществах для различных групп населения Российской Федерации, 2008. Методические рекомендации 2.3.1.2432-08.
44. Antopol W, Thomas M. Experimental study of the effects produced by large doses of vitamin B6. J Neuropathol Exp Neurol 1942; 1: 330–6.
45. Schaeppi U, Krinke G. Pyridoxine neuropathy: correlation of functional tests and neuropathology in beagle dogs treated with large doses of vita- min B6. Agents Actions 1982; 12: 575–82.
46. Krinke G, Naylor DC, Skorpil V. Pyridoxine megavitaminosis: an analysis of the early changes induced with massive doses of vitamin B6 in rat primary sensory neurons. J. Neuropathol Exp Neurol 1985; 44: 117–29.
47. Schaumburg HH, Kaplan J, Windebank AJ et al. Sensory neuropathy from pyridoxine abuse: a new megavitamin syndrome. N Eng J Med 1983; 309: 445–8.
48. Malmgren R, Collins A, Nilsson CG. Platelet serotonin uptake and effects of vitamin B6-treatment in premenstrual tension. Neuropsychobiology 1987; 18: 83–6.
Авторы
О.А.Громова1, В.Н.Серов2, Н.В.Керимкулова1, И.Ю.Торшин3, О.А.Лиманова1, Н.В.Никифорова1
1. ГБОУ ВПО Ивановская государственная медицинская академия Минздрава РФ
2. ФГБУ Научный центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова Минздрава РФ, Москва
3. ФУПМ Московский физико-технический институт
1. ГБОУ ВПО Ивановская государственная медицинская академия Минздрава РФ
2. ФГБУ Научный центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова Минздрава РФ, Москва
3. ФУПМ Московский физико-технический институт
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