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Прегравидарная подготовка эндометрия и вспомогательные репродуктивные технологии
Прегравидарная подготовка эндометрия и вспомогательные репродуктивные технологии
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Аннотация
В последнее десятилетие во всем мире отмечен значительный прогресс вспомогательных репродуктивных технологий, что выразилось в росте общего числа процедур и их доступности. Однако современной клинической задачей остается повышение эффективности и безопасности репродуктивных технологий. Оптимальная структура и рецептивность эндометрия в период имплантации хорошо известны как важнейшие факторы успеха вспомогательных репродуктивных технологий. На этапе подготовки к беременности пациенток с тонким эндометрием и другой патологией успешно используются трофические факторы с целью улучшения параметров рецептивности ткани.
Ключевые слова: вспомогательные репродуктивные технологии, ЭКО, эндометрий, Актовегин
Key words: secondary reproductive technologies, IVF, endometrium, Actovegin.
Ключевые слова: вспомогательные репродуктивные технологии, ЭКО, эндометрий, Актовегин
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Key words: secondary reproductive technologies, IVF, endometrium, Actovegin.
Полный текст
Список литературы
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2. CDC ART National Summary Report. www.cdc.gov.
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15. Boudjenah R, Molina-Gomes D, Wainer R. The vascular endothelial growth factor (VEGF) +405 G/C polymorphism and its relationship with recurrent implantation failure in women in an IVF programme with ICSI. J Assist Reprod Genet 2012; 29 (12): 1415–20.
16. Bourdiec A, Shao R, Rao CV. Human chorionic gonadotropin triggers angiogenesis via the modulation of endometrial stromal cell responsiveness to interleukin 1: a new possible mechanism underlying embryo implantation. Biol Reprod 2012; 87 (3): 66.
17. Check JH. The importance of sonographic endometrial parameters in influencing success following embryo transfer in the modern era and therapeutic options: the importance of late proliferative phase endometrial thickness. Clin Exp Obstet Gynecol 2011; 38 (3): 197–200.
18. Neeta S, Bahadur M, Mittal S. Predictive value of endometrial thickness, pattern and sub-endometrial blood flows on the day of hCG by 2D doppler in in-vitro fertilization cycles: A prospective clinical study from a tertiary care unit. J Hum Reprod Sci 2011; 4 (1): 29–33.
19. Salamonsen LA, Edgell T, Rombauts LJ. Proteomics of the human endometrium and uterine fluid: a pathway to biomarker discovery. Fertil Steril 2012; 6 (12): 2192–9.
20. Vilella F, Ramirez LB, Simon C. Lipidomics as an emerging tool to predict endometrial receptivity. Fertil Steril 2013. pii: S0015-0282(12)02535-6.
21. Boomsma CM, Keay SD, Macklon NS. Peri-implantation glucocorticoid administration for assisted reproductive technology cycles. Cochrane Database Syst Rev 2012; 6: CD005996.
22. Gargett CE, Healy DL. Generating receptive endometrium in Asherman's syndrome. J Hum Reprod Sci 2011; 4 (1): 49–52.
23. Gleicher N, Kim A, Michaeli T. A pilot cohort study of granulocyte colony-stimulating factor in the treatment of unresponsive thin endometrium resistant to standard therapies. Hum Reprod 2013; 1: 172–7.
24. Wang XW, Lin XY, Bi YH, Han JQ. Effect of actovegin on intestinal mucosa and expression of bcl-2/bax genes in rats with acute radiation enteritis. Zhonghua Zhong Liu Za Zhi 2009; 31 (10): 742–5.
2. CDC ART National Summary Report. www.cdc.gov.
3. ESHRE. Newsletters. www.eshre.eu.
4. Penzias AS. Recurrent IVF failure: other factors. Fertil Steril 2012; 97 (5): 1033–8.
5. Revel A. Defective endometrial receptivity. Fertil Steril 2012; 97 (5): 1028–32.
6. Senturk LM, Erel CT. Thin endometrium in assisted reproductive technology. Curr Opin Obstet Gynecol 2008; 20 (3): 221–8.
7. Simon A, Laufer N. Repeated implantation failure: clinical approach. Fertil Steril 2012; 97 (5): 1039–43.
8. Сухих Г.Т., Шуршалина А.В. Хронический эндометрит. М.: ГЭОТАР-Медиа, 2010.
9. Chronic endometritis is a frequent finding in women with recurrent implantation failures after in vitro fertilization. Fertil Steril 2010; 93 (2): 437–41.
10. Dekel N, Gnainsky Y, Granot I, Mor G. Inflammation and implantation. Am J Reprod Immunol 2010; 63 (1): 17–21.
11. Granot I, Gnainsky Y, Dekel N. Endometrial inflammation and effect on implantation improvement and pregnancy outcome. Reproduction 2012; 144 (6): 661–8.
12. Simon A, Laufer N. Assessment and treatment of repeated implantation failure (RIF). J Assist Reprod Genet 2012; 29 (11): 1227–39.
13. Horne AW, Critchley HO. The effect of uterine fibroids on embryo implantation. Semin Reprod Med 2007; 25 (6): 483–9.
14. Физиология человека. Под ред. Р.Шмидта, Г.Тевса. Пер. с англ. Т. 3–4. М., 1985.
15. Boudjenah R, Molina-Gomes D, Wainer R. The vascular endothelial growth factor (VEGF) +405 G/C polymorphism and its relationship with recurrent implantation failure in women in an IVF programme with ICSI. J Assist Reprod Genet 2012; 29 (12): 1415–20.
16. Bourdiec A, Shao R, Rao CV. Human chorionic gonadotropin triggers angiogenesis via the modulation of endometrial stromal cell responsiveness to interleukin 1: a new possible mechanism underlying embryo implantation. Biol Reprod 2012; 87 (3): 66.
17. Check JH. The importance of sonographic endometrial parameters in influencing success following embryo transfer in the modern era and therapeutic options: the importance of late proliferative phase endometrial thickness. Clin Exp Obstet Gynecol 2011; 38 (3): 197–200.
18. Neeta S, Bahadur M, Mittal S. Predictive value of endometrial thickness, pattern and sub-endometrial blood flows on the day of hCG by 2D doppler in in-vitro fertilization cycles: A prospective clinical study from a tertiary care unit. J Hum Reprod Sci 2011; 4 (1): 29–33.
19. Salamonsen LA, Edgell T, Rombauts LJ. Proteomics of the human endometrium and uterine fluid: a pathway to biomarker discovery. Fertil Steril 2012; 6 (12): 2192–9.
20. Vilella F, Ramirez LB, Simon C. Lipidomics as an emerging tool to predict endometrial receptivity. Fertil Steril 2013. pii: S0015-0282(12)02535-6.
21. Boomsma CM, Keay SD, Macklon NS. Peri-implantation glucocorticoid administration for assisted reproductive technology cycles. Cochrane Database Syst Rev 2012; 6: CD005996.
22. Gargett CE, Healy DL. Generating receptive endometrium in Asherman's syndrome. J Hum Reprod Sci 2011; 4 (1): 49–52.
23. Gleicher N, Kim A, Michaeli T. A pilot cohort study of granulocyte colony-stimulating factor in the treatment of unresponsive thin endometrium resistant to standard therapies. Hum Reprod 2013; 1: 172–7.
24. Wang XW, Lin XY, Bi YH, Han JQ. Effect of actovegin on intestinal mucosa and expression of bcl-2/bax genes in rats with acute radiation enteritis. Zhonghua Zhong Liu Za Zhi 2009; 31 (10): 742–5.
2. CDC ART National Summary Report. www.cdc.gov.
3. ESHRE. Newsletters. www.eshre.eu.
4. Penzias AS. Recurrent IVF failure: other factors. Fertil Steril 2012; 97 (5): 1033–8.
5. Revel A. Defective endometrial receptivity. Fertil Steril 2012; 97 (5): 1028–32.
6. Senturk LM, Erel CT. Thin endometrium in assisted reproductive technology. Curr Opin Obstet Gynecol 2008; 20 (3): 221–8.
7. Simon A, Laufer N. Repeated implantation failure: clinical approach. Fertil Steril 2012; 97 (5): 1039–43.
8. Сухих Г.Т., Шуршалина А.В. Хронический эндометрит. М.: ГЭОТАР-Медиа, 2010.
9. Chronic endometritis is a frequent finding in women with recurrent implantation failures after in vitro fertilization. Fertil Steril 2010; 93 (2): 437–41.
10. Dekel N, Gnainsky Y, Granot I, Mor G. Inflammation and implantation. Am J Reprod Immunol 2010; 63 (1): 17–21.
11. Granot I, Gnainsky Y, Dekel N. Endometrial inflammation and effect on implantation improvement and pregnancy outcome. Reproduction 2012; 144 (6): 661–8.
12. Simon A, Laufer N. Assessment and treatment of repeated implantation failure (RIF). J Assist Reprod Genet 2012; 29 (11): 1227–39.
13. Horne AW, Critchley HO. The effect of uterine fibroids on embryo implantation. Semin Reprod Med 2007; 25 (6): 483–9.
14. Физиология человека. Под ред. Р.Шмидта, Г.Тевса. Пер. с англ. Т. 3–4. М., 1985.
15. Boudjenah R, Molina-Gomes D, Wainer R. The vascular endothelial growth factor (VEGF) +405 G/C polymorphism and its relationship with recurrent implantation failure in women in an IVF programme with ICSI. J Assist Reprod Genet 2012; 29 (12): 1415–20.
16. Bourdiec A, Shao R, Rao CV. Human chorionic gonadotropin triggers angiogenesis via the modulation of endometrial stromal cell responsiveness to interleukin 1: a new possible mechanism underlying embryo implantation. Biol Reprod 2012; 87 (3): 66.
17. Check JH. The importance of sonographic endometrial parameters in influencing success following embryo transfer in the modern era and therapeutic options: the importance of late proliferative phase endometrial thickness. Clin Exp Obstet Gynecol 2011; 38 (3): 197–200.
18. Neeta S, Bahadur M, Mittal S. Predictive value of endometrial thickness, pattern and sub-endometrial blood flows on the day of hCG by 2D doppler in in-vitro fertilization cycles: A prospective clinical study from a tertiary care unit. J Hum Reprod Sci 2011; 4 (1): 29–33.
19. Salamonsen LA, Edgell T, Rombauts LJ. Proteomics of the human endometrium and uterine fluid: a pathway to biomarker discovery. Fertil Steril 2012; 6 (12): 2192–9.
20. Vilella F, Ramirez LB, Simon C. Lipidomics as an emerging tool to predict endometrial receptivity. Fertil Steril 2013. pii: S0015-0282(12)02535-6.
21. Boomsma CM, Keay SD, Macklon NS. Peri-implantation glucocorticoid administration for assisted reproductive technology cycles. Cochrane Database Syst Rev 2012; 6: CD005996.
22. Gargett CE, Healy DL. Generating receptive endometrium in Asherman's syndrome. J Hum Reprod Sci 2011; 4 (1): 49–52.
23. Gleicher N, Kim A, Michaeli T. A pilot cohort study of granulocyte colony-stimulating factor in the treatment of unresponsive thin endometrium resistant to standard therapies. Hum Reprod 2013; 1: 172–7.
24. Wang XW, Lin XY, Bi YH, Han JQ. Effect of actovegin on intestinal mucosa and expression of bcl-2/bax genes in rats with acute radiation enteritis. Zhonghua Zhong Liu Za Zhi 2009; 31 (10): 742–5.
________________________________________________
2. CDC ART National Summary Report. www.cdc.gov.
3. ESHRE. Newsletters. www.eshre.eu.
4. Penzias AS. Recurrent IVF failure: other factors. Fertil Steril 2012; 97 (5): 1033–8.
5. Revel A. Defective endometrial receptivity. Fertil Steril 2012; 97 (5): 1028–32.
6. Senturk LM, Erel CT. Thin endometrium in assisted reproductive technology. Curr Opin Obstet Gynecol 2008; 20 (3): 221–8.
7. Simon A, Laufer N. Repeated implantation failure: clinical approach. Fertil Steril 2012; 97 (5): 1039–43.
8. Сухих Г.Т., Шуршалина А.В. Хронический эндометрит. М.: ГЭОТАР-Медиа, 2010.
9. Chronic endometritis is a frequent finding in women with recurrent implantation failures after in vitro fertilization. Fertil Steril 2010; 93 (2): 437–41.
10. Dekel N, Gnainsky Y, Granot I, Mor G. Inflammation and implantation. Am J Reprod Immunol 2010; 63 (1): 17–21.
11. Granot I, Gnainsky Y, Dekel N. Endometrial inflammation and effect on implantation improvement and pregnancy outcome. Reproduction 2012; 144 (6): 661–8.
12. Simon A, Laufer N. Assessment and treatment of repeated implantation failure (RIF). J Assist Reprod Genet 2012; 29 (11): 1227–39.
13. Horne AW, Critchley HO. The effect of uterine fibroids on embryo implantation. Semin Reprod Med 2007; 25 (6): 483–9.
14. Физиология человека. Под ред. Р.Шмидта, Г.Тевса. Пер. с англ. Т. 3–4. М., 1985.
15. Boudjenah R, Molina-Gomes D, Wainer R. The vascular endothelial growth factor (VEGF) +405 G/C polymorphism and its relationship with recurrent implantation failure in women in an IVF programme with ICSI. J Assist Reprod Genet 2012; 29 (12): 1415–20.
16. Bourdiec A, Shao R, Rao CV. Human chorionic gonadotropin triggers angiogenesis via the modulation of endometrial stromal cell responsiveness to interleukin 1: a new possible mechanism underlying embryo implantation. Biol Reprod 2012; 87 (3): 66.
17. Check JH. The importance of sonographic endometrial parameters in influencing success following embryo transfer in the modern era and therapeutic options: the importance of late proliferative phase endometrial thickness. Clin Exp Obstet Gynecol 2011; 38 (3): 197–200.
18. Neeta S, Bahadur M, Mittal S. Predictive value of endometrial thickness, pattern and sub-endometrial blood flows on the day of hCG by 2D doppler in in-vitro fertilization cycles: A prospective clinical study from a tertiary care unit. J Hum Reprod Sci 2011; 4 (1): 29–33.
19. Salamonsen LA, Edgell T, Rombauts LJ. Proteomics of the human endometrium and uterine fluid: a pathway to biomarker discovery. Fertil Steril 2012; 6 (12): 2192–9.
20. Vilella F, Ramirez LB, Simon C. Lipidomics as an emerging tool to predict endometrial receptivity. Fertil Steril 2013. pii: S0015-0282(12)02535-6.
21. Boomsma CM, Keay SD, Macklon NS. Peri-implantation glucocorticoid administration for assisted reproductive technology cycles. Cochrane Database Syst Rev 2012; 6: CD005996.
22. Gargett CE, Healy DL. Generating receptive endometrium in Asherman's syndrome. J Hum Reprod Sci 2011; 4 (1): 49–52.
23. Gleicher N, Kim A, Michaeli T. A pilot cohort study of granulocyte colony-stimulating factor in the treatment of unresponsive thin endometrium resistant to standard therapies. Hum Reprod 2013; 1: 172–7.
24. Wang XW, Lin XY, Bi YH, Han JQ. Effect of actovegin on intestinal mucosa and expression of bcl-2/bax genes in rats with acute radiation enteritis. Zhonghua Zhong Liu Za Zhi 2009; 31 (10): 742–5.
Авторы
А.В.Шуршалина
Университет Тафтс, Бостон (США)
Университет Тафтс, Бостон (США)
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