Молекулярно-генетические аспекты процесса имплантации у пациенток программы экстракорпорального оплодотворения (обзор литературы)

1. Бурлев В.А., Гаспаров А.С., Аванесян Н.С. Факторы роста и их роль в регуляции репродуктивной функции у больных с синдромом поликистозных яичников. Проблемы репродукции. 1998; 3: 17–25.
2. Ольховская М.А. Биомаркеры «имплантационного окна». Проблемы репродукции. 2007; 1: 72–7.
3. Шуршалина А.В. Автореф. дис. … д-ра мед. наук. М., 2007.
4. Brayman M, Thathiah A, Carson DD. MUC-1: a multifunctional cell surface component of reproductive tissue epithelia. Reprod Biol Endocrinol 2004; 2: 4.
5. Curry TE Jr, Osteen KG. The matrix metalloproteinase system: changes, regulation, and impact throughout the ovarian and uterine reproductive cycle. Endocr Rev 2003; 24 (4): 428–65.
6. Dimitriadis E et al. Cytokines, chemokines and growth factors in endometrium related to implantation. Hum Reprod 2005; 11 (6): 613–30.
7. Banu SK et al. Cyclooxygenase-2 Regulates Survival, Migration and Invasion of Human Endometriotic Cells through Multiple Mechanisms. Published online before print November 26, 2007, doi: 10.1210. en.2007–1168. Endocrinol 2008; 149 (3): 1180–9.
8. Donaghay M, Lessey BA. Receptivity: alterations associated with benign gynecological disease. Semin Reprod Med 2007; 25: 461–75.
9. Altmäe S et al. Endometrial gene expression analysis at the time of embryo implantation in women with unexplained infertility. Mol Hum Reprod 2010; 16 (3): 178–87.
10. Boomsma CM et al. Endometrial secretion analysis identifies a cytokine profile predictive of pregnancy in IVF. Hum Reprod 2009; 24 (6): 1427–35.
11. Rahnama F et al. Epigenetic regulation of E-cadherin controls endometrial receptivity. Endocrinol 2009; 150 (3): 1466–72.
12. Serafini P et al. Endometrial leukemia inhibitory factor as a predictor of pregnancy after in vitro fertilization. Int J Gynecol Obstet 2008; 102: 23–7.
13. Franchi A et al. Expression of immunomodulatory genes, their protein products and specific ligands. receptors during the window of implantation in the human endometrium. Mol Hum Reprod 2008; 14 (7): 413–21.
14. Chung IB et al. Expression and regulation of vascular endothelial growth factor in a first trimester trophoblast cell line. Placenta 2000; 21: 320–4.
15. Jee BC et al. Expression of vascular endothelial growth factor-A and its receptor-1 in a luteal endometrium in patients with repeated in vitro fertilization failure. Fertil Steril 2009; 91 (2): 528–34.
16. St-Louis I et al. Expression of COX-1 and COX-2 in the endometrium of cyclic, pregnant and in a model of pseudopregnant rats and their regulation by sex steroids. Reprod Biol Endocrinol 2010; 8: 103.
17. Guzeloglu-Kayisli O, Kayisli UA, Taylor HS. The Role of Growth Factors and Cytokines during Implantation: Endocrine and Paracrine Interactions. Semin Reprod Med 2009; 27 (1): 62–79.
18. Aghajanova L et al. HB-EGF but not amphiregulin or their receptors HER1 and HER4 is altered in endometrium of women with unexplained infertility. Reprod Sci 2008; 15, 5: 484–92.
19. Herington JL, Bany BM. The conceptus increases secreted phosphoprotein 1 gene expression in the mouse uterus during the progression of decidualization mainly due to its effects on uterine natural killer cells. Reprod 2007; 133: 1213–21.
20. Chobotova K et al. Heparin-binding epidermal growth factor and its receptors mediate decidualization and potentiate survival of human endometrial stromal cells. J Clin Endocr Metab 2005; 90 (2): 913–9.
21. Tsuzuki T et al. Hypoxic stress simultaneously stimulates vascular endothelial growth factor via hypoxia-inducible factor-1a and inhibits stromal cell-derived factor-1 in human endometrial stromal cells. Hum Reprod 2012; 27 (2): 523–30.
22. Allegra А et al. Is there a uniform basal endometrial gene expression profile during the implantation window in women who became pregnant in a subsequent ICSI cycle? Hum Reprod 2009; 24: 2549–57.
23. Jasper MJ, Tremellen KP, Robertson SA. Reduced expression of IL-6 and IL-1 alpha mRNAs in secretory phase endometrium of women with recurrent miscarriage. J Reprod Immunol 2007; 73: 74–84.
24. Kovalevsky G, Patrizio P. High rates of embryo wastage with use of assisted reproductive technology: a look at the trends between 1995 and 2001 in the United States. Fertil Steril 2005; 84: 325–30.
25. Lu Z, Hardt J, Kim JJ. Global analysis of genes regulated by HOXA10 in decidualization reveals a role in cell proliferation. Mol Hum Reprod 2008; 14: 357–66.
26. Matsumoto H, Sakai K, Iwashita M. Insulin-like growth factor binding protein-1 induces decidualization of human endometrial stromal cells via a5b1 integrin. Mol Hum Reprod 2008; 14 (8): 485–9.
27. Mariee N, Li TC, Laird SM. Expression of leukaemia inhibitory factor and interleukin 15 in endometrium of women with recurrent implantation failure after IVF; correlation with the number of endometrial natural killer cells. Hum Reprod 2012; 27 (7): 1946–54.
28. Ponnampalam AP et al. Molecular classification of human endometrial cycle stages by transcriptional profiling. Mol Hum Reprod 2004; 10: 879–93.
29. Quinn CE, Casper RF. First published online: November 8, 2008.
30. Pinopodes: a quest ionable role in endometrial receptivity. Hum Reprod Update 2009; 15 (2): 229–36.
31. Makrigiannakisa A et al. Recent advances in understanding immunology of reproductive failure. J Reprod Immunol 2011; 90: 96–104.
32. Brinsden PR et al. Recombinant human leukemia inhibitory factor does not improve implantation and pregnancy outcomes after assisted reproductive techniques in women with recurrent unexplained implantation failure. Fertil Steril 2009; 91: 1445–7.
33. Sarno JL, Kliman HJ, Taylor HS. HOXA10, Pbx2, and Meis1 protein expression in the human endometrium: formation of multimeric complexes on HOXA10 target genes. J Clin Endocrinol Metab 2005; 90: (1): 522–8.
34. Singh M, Chaudhry P, Asselin E. Bridging endometrial receptivity and implantation: network of hormones, cytokines, and growth factors. Published online before print March 3, 2011, doi: 10.1530. JOE-10-0461. J Endocrinol 2011; 210: 5–14.
35. Simon A, Laufer N. Assessment and treatment of repeated implantation failure (RIF). J Assist Reprod Genet 2012; 29 (N): 11: 1227–39.
36. Sharma A, Kumar P. Understanding implantation window, a crucial phenomenon. J Hum Reprod Sci 2012; 5 (1): 2–6.
37. Salamonsen LA et al. Society for Reproductive Biology Founders' Lecture 2009. Preparing fertile soil: the importance of endometrial receptivity. Reprod Fertil 2009; 21 (7): 923–34.
38. Usadi RS et al. Temporal and morphologic characteristics of pinopod expression across the secretory phase of the endometrial cycle in normally cycling women with proven fertility. Fertil Steril 2003; 79: 970–4.
39. Al-Azemi M et al. The expression of MUC1 in human Fallopian tube during the menstrual cycle and in ectopic pregnancy. Hum Repro. 2009; 24 (10): 2582–7.
40. Strowitzki T et al. The human endometrium as a fertility-determining factor. Hum Reprod 2006; 12 (5): 617–30.

________________________________________________

1. Бурлев В.А., Гаспаров А.С., Аванесян Н.С. Факторы роста и их роль в регуляции репродуктивной функции у больных с синдромом поликистозных яичников. Проблемы репродукции. 1998; 3: 17–25.
2. Ольховская М.А. Биомаркеры «имплантационного окна». Проблемы репродукции. 2007; 1: 72–7.
3. Шуршалина А.В. Автореф. дис. … д-ра мед. наук. М., 2007.
4. Brayman M, Thathiah A, Carson DD. MUC-1: a multifunctional cell surface component of reproductive tissue epithelia. Reprod Biol Endocrinol 2004; 2: 4.
5. Curry TE Jr, Osteen KG. The matrix metalloproteinase system: changes, regulation, and impact throughout the ovarian and uterine reproductive cycle. Endocr Rev 2003; 24 (4): 428–65.
6. Dimitriadis E et al. Cytokines, chemokines and growth factors in endometrium related to implantation. Hum Reprod 2005; 11 (6): 613–30.
7. Banu SK et al. Cyclooxygenase-2 Regulates Survival, Migration and Invasion of Human Endometriotic Cells through Multiple Mechanisms. Published online before print November 26, 2007, doi: 10.1210. en.2007–1168. Endocrinol 2008; 149 (3): 1180–9.
8. Donaghay M, Lessey BA. Receptivity: alterations associated with benign gynecological disease. Semin Reprod Med 2007; 25: 461–75.
9. Altmäe S et al. Endometrial gene expression analysis at the time of embryo implantation in women with unexplained infertility. Mol Hum Reprod 2010; 16 (3): 178–87.
10. Boomsma CM et al. Endometrial secretion analysis identifies a cytokine profile predictive of pregnancy in IVF. Hum Reprod 2009; 24 (6): 1427–35.
11. Rahnama F et al. Epigenetic regulation of E-cadherin controls endometrial receptivity. Endocrinol 2009; 150 (3): 1466–72.
12. Serafini P et al. Endometrial leukemia inhibitory factor as a predictor of pregnancy after in vitro fertilization. Int J Gynecol Obstet 2008; 102: 23–7.
13. Franchi A et al. Expression of immunomodulatory genes, their protein products and specific ligands. receptors during the window of implantation in the human endometrium. Mol Hum Reprod 2008; 14 (7): 413–21.
14. Chung IB et al. Expression and regulation of vascular endothelial growth factor in a first trimester trophoblast cell line. Placenta 2000; 21: 320–4.
15. Jee BC et al. Expression of vascular endothelial growth factor-A and its receptor-1 in a luteal endometrium in patients with repeated in vitro fertilization failure. Fertil Steril 2009; 91 (2): 528–34.
16. St-Louis I et al. Expression of COX-1 and COX-2 in the endometrium of cyclic, pregnant and in a model of pseudopregnant rats and their regulation by sex steroids. Reprod Biol Endocrinol 2010; 8: 103.
17. Guzeloglu-Kayisli O, Kayisli UA, Taylor HS. The Role of Growth Factors and Cytokines during Implantation: Endocrine and Paracrine Interactions. Semin Reprod Med 2009; 27 (1): 62–79.
18. Aghajanova L et al. HB-EGF but not amphiregulin or their receptors HER1 and HER4 is altered in endometrium of women with unexplained infertility. Reprod Sci 2008; 15, 5: 484–92.
19. Herington JL, Bany BM. The conceptus increases secreted phosphoprotein 1 gene expression in the mouse uterus during the progression of decidualization mainly due to its effects on uterine natural killer cells. Reprod 2007; 133: 1213–21.
20. Chobotova K et al. Heparin-binding epidermal growth factor and its receptors mediate decidualization and potentiate survival of human endometrial stromal cells. J Clin Endocr Metab 2005; 90 (2): 913–9.
21. Tsuzuki T et al. Hypoxic stress simultaneously stimulates vascular endothelial growth factor via hypoxia-inducible factor-1a and inhibits stromal cell-derived factor-1 in human endometrial stromal cells. Hum Reprod 2012; 27 (2): 523–30.
22. Allegra А et al. Is there a uniform basal endometrial gene expression profile during the implantation window in women who became pregnant in a subsequent ICSI cycle? Hum Reprod 2009; 24: 2549–57.
23. Jasper MJ, Tremellen KP, Robertson SA. Reduced expression of IL-6 and IL-1 alpha mRNAs in secretory phase endometrium of women with recurrent miscarriage. J Reprod Immunol 2007; 73: 74–84.
24. Kovalevsky G, Patrizio P. High rates of embryo wastage with use of assisted reproductive technology: a look at the trends between 1995 and 2001 in the United States. Fertil Steril 2005; 84: 325–30.
25. Lu Z, Hardt J, Kim JJ. Global analysis of genes regulated by HOXA10 in decidualization reveals a role in cell proliferation. Mol Hum Reprod 2008; 14: 357–66.
26. Matsumoto H, Sakai K, Iwashita M. Insulin-like growth factor binding protein-1 induces decidualization of human endometrial stromal cells via a5b1 integrin. Mol Hum Reprod 2008; 14 (8): 485–9.
27. Mariee N, Li TC, Laird SM. Expression of leukaemia inhibitory factor and interleukin 15 in endometrium of women with recurrent implantation failure after IVF; correlation with the number of endometrial natural killer cells. Hum Reprod 2012; 27 (7): 1946–54.
28. Ponnampalam AP et al. Molecular classification of human endometrial cycle stages by transcriptional profiling. Mol Hum Reprod 2004; 10: 879–93.
29. Quinn CE, Casper RF. First published online: November 8, 2008.
30. Pinopodes: a quest ionable role in endometrial receptivity. Hum Reprod Update 2009; 15 (2): 229–36.
31. Makrigiannakisa A et al. Recent advances in understanding immunology of reproductive failure. J Reprod Immunol 2011; 90: 96–104.
32. Brinsden PR et al. Recombinant human leukemia inhibitory factor does not improve implantation and pregnancy outcomes after assisted reproductive techniques in women with recurrent unexplained implantation failure. Fertil Steril 2009; 91: 1445–7.
33. Sarno JL, Kliman HJ, Taylor HS. HOXA10, Pbx2, and Meis1 protein expression in the human endometrium: formation of multimeric complexes on HOXA10 target genes. J Clin Endocrinol Metab 2005; 90: (1): 522–8.
34. Singh M, Chaudhry P, Asselin E. Bridging endometrial receptivity and implantation: network of hormones, cytokines, and growth factors. Published online before print March 3, 2011, doi: 10.1530. JOE-10-0461. J Endocrinol 2011; 210: 5–14.
35. Simon A, Laufer N. Assessment and treatment of repeated implantation failure (RIF). J Assist Reprod Genet 2012; 29 (N): 11: 1227–39.
36. Sharma A, Kumar P. Understanding implantation window, a crucial phenomenon. J Hum Reprod Sci 2012; 5 (1): 2–6.
37. Salamonsen LA et al. Society for Reproductive Biology Founders' Lecture 2009. Preparing fertile soil: the importance of endometrial receptivity. Reprod Fertil 2009; 21 (7): 923–34.
38. Usadi RS et al. Temporal and morphologic characteristics of pinopod expression across the secretory phase of the endometrial cycle in normally cycling women with proven fertility. Fertil Steril 2003; 79: 970–4.
39. Al-Azemi M et al. The expression of MUC1 in human Fallopian tube during the menstrual cycle and in ectopic pregnancy. Hum Repro. 2009; 24 (10): 2582–7.
40. Strowitzki T et al. The human endometrium as a fertility-determining factor. Hum Reprod 2006; 12 (5): 617–30.

М.А.Охрименко, Д.А.Хачатурян, В.Ю.Смольникова, А.Е.Донников

ФГБУ Научный центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова Минздрава России, Москва

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M.A.Okhrimenko, D.A.Khachaturyan, V.Y.Smolnikova, A.E.Donnikov