В статье рассматриваются аспекты антибактериальной терапии у пациенток с бактериальным вагинозом, в том числе преимущества вагинальных суппозиториев Нео-Пенотран® Форте.
The paper covers the aspects of antibiotic therapy in patients with bacterial vaginosis, including the advantages of Neo-Penotran® Forte vaginal suppositories.
1. Angotti OL, Lambert LC, Soper DE. Vaginitis: Making Sense of Over-the-Counter Treatment Options. Infect Dis Obstet Gynecol 2007.
2. Fidler B. Over-the-counter management of vaginal yeast infections. Drug Store News 2006: 23–7.
3. Swadpanich U, Lumbiganon P, Prasertcharoensook W, Laopaiboon M. Antenatal lower genital tract infection screening and treatment programs for preventing preterm delivery. Cochrane Database Syst Rev 2008.
4. Прилепская В.Н., Анкирская А.С., Муравьева В.В. и др. Препарат «Тиберал» в лечении бактериального вагиноза. Гинекология. 2006; 4: 44–7.
5. Дмитриева М.В. Роль условно-патогенной бактериальной флоры в развитии и течении рецидивирующих уретритов и хронических бактериальных простатитов, совершенствование этиотропной терапии. Дис. ... канд. мед. наук. 2007.
6. Прилепская В.Н., Байрамова Г.Р. Современные представления о бактериальном вагинозе. Вестн. рос. ассоц. акушеров-гинекологов. 1996; 3: 40–2.
7. van Oostrum N, De Sutter P, Meys J, Verstraelen H. Risks associated with bacterial vaginosis in infertility patients: a systematic review and meta-analysis. Hum Reprod 2013. [Epub ahead of print].
8. Ness RB, Kip KE, Hillier SL et al. Richter A Cluster Analysis of Bacterial Vaginosis–associated Microflora and Pelvic Inflammatory Disease. Am J Epidemiol 2005; 162 (6): 585–90.
9. Andrews WW, Hauth JC, Cliver SP et al. Goepfert Association of asymptomatic bacterial vaginosis with endometrial microbial colonization and plasma cell endometritis in nonpregnant women. Am J of Obstet Gynecol 2006; 195 (6).
10. Haggerty CL, Hillier SL, Bass DC, Ness RB. Bacterial Vaginosis and Anaerobic Bacteria Are Associated with Endometritis. Clin Infect Dis 2004; 39: 990–5.
11. Миннуллина Ф.Ф. Состояние эндометрия у женщин репродуктивного возраста при рецидивирующем бактериальном вагинозе. Дисс. ... канд. мед. наук. Казань, 2004.
12. Воропаева Е.Е. Клинико-морфологические аспекты оптимизации лечения бактериального вагиноза, ассоциированного с хроническими воспалительными заболеваниями матки. Дисс. ... канд. мед. наук. Омск, 2005.
13. Brotman RM, Klebanoff MA, Nansel TR et al. Bacterial vaginosis assessed by gram stain and diminished colonization resistance to incident gonococcal, chlamydial, and trichomonal genital infection. J Infect Dis 2010; 202: 1907–15.
14. Allsworth JE, Lewis VA, Peipert JF. Viral sexually transmitted infections and bacterial vaginosis: 2001–2004 National Health and Nutrition Examination Survey data. Sex Transm Dis 2008; 35: 791–6.
15. Gillet E, Meys JFA, Verstraelen H et al. Bacterial vaginosis is associated with uterine cervical human apillomavirus infection: a meta-analysis. PLoS One 2012; 7 (10).
16. Роговская С.И., Прилепская В.Н. Бактериальный вагиноз и папилломавирусная инфекция. Гинекология. 2002; 4 (3): 126–30.
17. Menard J-P. Antibacterial treatment of bacterial vaginosis: current and emerging therapies. Int J Womens Health 2011; 3: 295–305.
18. Fethers KA, Fairley CK, Hocking JS et al. Sexual risk factors and bacterial vaginosis: a systematic review and meta-analysis. Clin Infect Dis 2008; 47: 1426–35.
19. Cherpes TL, Hillier SL, Meyn LA et al. A delicate balance: risk factors for acquisition of bacterial vaginosis include sexual activity, absence of hydrogen peroxide-producing lactobacilli, black race, and positive herpes simplex virus type 2 serology. Sex Transm Dis 2008; 35: 78–83.
20. Nikhil Kumar, Beauty Behera, Sai S. Sagiri, Kunal Pal, Sirsendu S. Ray, and Saroj Roy. Bacterial vaginosis: Etiology and modalities of treatment – A brief note. J Pharm Bioallied Sci 2011; 3 (4): 496–503.
21. Тихомиров А.Л., Олейник Ч.Г. Бактериальный вагиноз: некоторые аспекты этиологии, патогенеза, клиники, диагностики и лечения. Con. Med. 2004; 6 (2).
22. Larsson P-G, Brandsborg E, Forsum U et al. Extended antimicrobial treatment of bacterial vaginosis combined with human lactobacilli to find the best treatment and minimize the risk of relapses. BMC Infect Dis 2011; 11: 223.
23. Bradshaw CS, Morton AN, Hocking J et al. High recurrence rates of bacterial vaginosis over the course of 12 months after oral metronidazole therapy and factors associated with recurrence. J Infect Dis 2006; 193 (11): 1478–86.
24. Verstraelen H, Verhelst R, Vaneechoutte M, Temmerman M. The epidemiology of bacterial vaginosis in relation to sexual behaviour. BMC Infect Dis 2010; 10: 81.
25. Klebanoff MA, Andrews WW, Zhang J et al. Race of male sex partners and occurrence of bacterial vaginosis. Sex Transm Dis 2010; 37 (3): 184–90.
26. Ness RB, Kip KE, Hillier SL et al. Richter A Cluster Analysis of Bacterial Vaginosis – associated Microflora and Pelvic Inflammatory Disease. Am J Epidemiol 2005; 162 (6): 585–90.
27. Mehta SD. Systematic review of randomized trials of treatment of male sexual partners for improved bacteria vaginosis outcomes in women. Sex Transm Dis 2012; 39 (10): 822–30.
28. Allsworth JE, Peipert JF. Severity of Bacterial Vaginosis and the Risk of Sexually Transmitted Infection. Am J Obstet Gynecol 2011; 205 (2): 113.e1–113.e6.
29. Bradshaw CS, Tabrizi SN, Fairley CK et al. The association of Atopobium vaginae and Gardnerella vaginalis with bacterial vaginosis and recurrence after oral metronidazole therapy. J Infect Dis 2006; 194: 828–36.
30. Wilson J. Managing recurrent bacterial vaginosis. Sex Transm Infect 2004; 80 (1): 8–11.
31. Bradshaw CS, Walker J, Fairley CK et al. Prevalent and Incident Bacterial Vaginosis Are Associated with Sexual and Contraceptive Behaviours in Young Australian Women. PLoS One 2013; 8 (3): e57688.
32. Swidsinski A, Verstraelen H, Loening-Baucke V et al. Presence of a Polymicrobial Endometrial Biofilm in Patients with Bacterial Vaginosis. PLoS One 2013; 8 (1): e53997.
33. Oduyebo OO, Anorlu RI, Ogunsola FT. The effects of antimicrobial therapy on bacterial vaginosis in non-pregnant women. Cochrane Database of Systematic Reviews 2009; 3.
34. Sanchez S, Garcia PJ. Intravaginal metronidazole gel versus metronidazole plus nystatin ovules for BV: A randomized controlled trial. Am J Obstet Gynecol 2004; 191: 1898–906.
________________________________________________
1. Angotti OL, Lambert LC, Soper DE. Vaginitis: Making Sense of Over-the-Counter Treatment Options. Infect Dis Obstet Gynecol 2007.
2. Fidler B. Over-the-counter management of vaginal yeast infections. Drug Store News 2006: 23–7.
3. Swadpanich U, Lumbiganon P, Prasertcharoensook W, Laopaiboon M. Antenatal lower genital tract infection screening and treatment programs for preventing preterm delivery. Cochrane Database Syst Rev 2008.
4. Прилепская В.Н., Анкирская А.С., Муравьева В.В. и др. Препарат «Тиберал» в лечении бактериального вагиноза. Гинекология. 2006; 4: 44–7.
5. Дмитриева М.В. Роль условно-патогенной бактериальной флоры в развитии и течении рецидивирующих уретритов и хронических бактериальных простатитов, совершенствование этиотропной терапии. Дис. ... канд. мед. наук. 2007.
6. Прилепская В.Н., Байрамова Г.Р. Современные представления о бактериальном вагинозе. Вестн. рос. ассоц. акушеров-гинекологов. 1996; 3: 40–2.
7. van Oostrum N, De Sutter P, Meys J, Verstraelen H. Risks associated with bacterial vaginosis in infertility patients: a systematic review and meta-analysis. Hum Reprod 2013. [Epub ahead of print].
8. Ness RB, Kip KE, Hillier SL et al. Richter A Cluster Analysis of Bacterial Vaginosis–associated Microflora and Pelvic Inflammatory Disease. Am J Epidemiol 2005; 162 (6): 585–90.
9. Andrews WW, Hauth JC, Cliver SP et al. Goepfert Association of asymptomatic bacterial vaginosis with endometrial microbial colonization and plasma cell endometritis in nonpregnant women. Am J of Obstet Gynecol 2006; 195 (6).
10. Haggerty CL, Hillier SL, Bass DC, Ness RB. Bacterial Vaginosis and Anaerobic Bacteria Are Associated with Endometritis. Clin Infect Dis 2004; 39: 990–5.
11. Миннуллина Ф.Ф. Состояние эндометрия у женщин репродуктивного возраста при рецидивирующем бактериальном вагинозе. Дисс. ... канд. мед. наук. Казань, 2004.
12. Воропаева Е.Е. Клинико-морфологические аспекты оптимизации лечения бактериального вагиноза, ассоциированного с хроническими воспалительными заболеваниями матки. Дисс. ... канд. мед. наук. Омск, 2005.
13. Brotman RM, Klebanoff MA, Nansel TR et al. Bacterial vaginosis assessed by gram stain and diminished colonization resistance to incident gonococcal, chlamydial, and trichomonal genital infection. J Infect Dis 2010; 202: 1907–15.
14. Allsworth JE, Lewis VA, Peipert JF. Viral sexually transmitted infections and bacterial vaginosis: 2001–2004 National Health and Nutrition Examination Survey data. Sex Transm Dis 2008; 35: 791–6.
15. Gillet E, Meys JFA, Verstraelen H et al. Bacterial vaginosis is associated with uterine cervical human apillomavirus infection: a meta-analysis. PLoS One 2012; 7 (10).
16. Роговская С.И., Прилепская В.Н. Бактериальный вагиноз и папилломавирусная инфекция. Гинекология. 2002; 4 (3): 126–30.
17. Menard J-P. Antibacterial treatment of bacterial vaginosis: current and emerging therapies. Int J Womens Health 2011; 3: 295–305.
18. Fethers KA, Fairley CK, Hocking JS et al. Sexual risk factors and bacterial vaginosis: a systematic review and meta-analysis. Clin Infect Dis 2008; 47: 1426–35.
19. Cherpes TL, Hillier SL, Meyn LA et al. A delicate balance: risk factors for acquisition of bacterial vaginosis include sexual activity, absence of hydrogen peroxide-producing lactobacilli, black race, and positive herpes simplex virus type 2 serology. Sex Transm Dis 2008; 35: 78–83.
20. Nikhil Kumar, Beauty Behera, Sai S. Sagiri, Kunal Pal, Sirsendu S. Ray, and Saroj Roy. Bacterial vaginosis: Etiology and modalities of treatment – A brief note. J Pharm Bioallied Sci 2011; 3 (4): 496–503.
21. Тихомиров А.Л., Олейник Ч.Г. Бактериальный вагиноз: некоторые аспекты этиологии, патогенеза, клиники, диагностики и лечения. Con. Med. 2004; 6 (2).
22. Larsson P-G, Brandsborg E, Forsum U et al. Extended antimicrobial treatment of bacterial vaginosis combined with human lactobacilli to find the best treatment and minimize the risk of relapses. BMC Infect Dis 2011; 11: 223.
23. Bradshaw CS, Morton AN, Hocking J et al. High recurrence rates of bacterial vaginosis over the course of 12 months after oral metronidazole therapy and factors associated with recurrence. J Infect Dis 2006; 193 (11): 1478–86.
24. Verstraelen H, Verhelst R, Vaneechoutte M, Temmerman M. The epidemiology of bacterial vaginosis in relation to sexual behaviour. BMC Infect Dis 2010; 10: 81.
25. Klebanoff MA, Andrews WW, Zhang J et al. Race of male sex partners and occurrence of bacterial vaginosis. Sex Transm Dis 2010; 37 (3): 184–90.
26. Ness RB, Kip KE, Hillier SL et al. Richter A Cluster Analysis of Bacterial Vaginosis – associated Microflora and Pelvic Inflammatory Disease. Am J Epidemiol 2005; 162 (6): 585–90.
27. Mehta SD. Systematic review of randomized trials of treatment of male sexual partners for improved bacteria vaginosis outcomes in women. Sex Transm Dis 2012; 39 (10): 822–30.
28. Allsworth JE, Peipert JF. Severity of Bacterial Vaginosis and the Risk of Sexually Transmitted Infection. Am J Obstet Gynecol 2011; 205 (2): 113.e1–113.e6.
29. Bradshaw CS, Tabrizi SN, Fairley CK et al. The association of Atopobium vaginae and Gardnerella vaginalis with bacterial vaginosis and recurrence after oral metronidazole therapy. J Infect Dis 2006; 194: 828–36.
30. Wilson J. Managing recurrent bacterial vaginosis. Sex Transm Infect 2004; 80 (1): 8–11.
31. Bradshaw CS, Walker J, Fairley CK et al. Prevalent and Incident Bacterial Vaginosis Are Associated with Sexual and Contraceptive Behaviours in Young Australian Women. PLoS One 2013; 8 (3): e57688.
32. Swidsinski A, Verstraelen H, Loening-Baucke V et al. Presence of a Polymicrobial Endometrial Biofilm in Patients with Bacterial Vaginosis. PLoS One 2013; 8 (1): e53997.
33. Oduyebo OO, Anorlu RI, Ogunsola FT. The effects of antimicrobial therapy on bacterial vaginosis in non-pregnant women. Cochrane Database of Systematic Reviews 2009; 3.
34. Sanchez S, Garcia PJ. Intravaginal metronidazole gel versus metronidazole plus nystatin ovules for BV: A randomized controlled trial. Am J Obstet Gynecol 2004; 191: 1898–906.
Авторы
И.Ю.Фофанова, В.Н Прилепская
ФГБУ Научный центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова Минздрава России, Москва