В статье представлены современные данные об этиопатогенезе атрофического вульвовагинита, диагностические критерии, клинические проявления и современные препараты, применяемые для лечения этого патологического состояния.
The article presents the current data on the etiopathogenesis of atrophic vulvovaginitis, diagnostic criteria, clinical manifestations and modern drugs used to treat the pathological condition.
1. Spinillo A, Bernuzzi AM, Cevini C et al. The relationship of bacterial vaginosis, Candida and Trichomonas infection to symptomatic vaginitis in postmenopausal women attending a vaginitis clinic. Maturitas 1997; 27 (3): 253–60.
2. Балан В.Е. Принципы заместительной гормонотерапии урогенитальных расстройств. Гинекология. 2000; 2 (5): 140–2.
3. Сметник В.П. Руководство по климактерию. Под ред. В.П.Сметник, В.И.Кулакова. М.: МИА, 2001.
4. Nappi RE, Kokot-Kierepa M. Women's voices in the menopause: results from an international survey on vaginal atrophy. Maturitas 2010; 67: 233.
5. Bachmann GA, Nevadunsky NS. Diagnosis and treatment of atrophic vaginitis. Am Fam Physician 2000; 61: 3090.
6. Kao A et al. Dyspareunia in postmenopausal women: a critical review. Pain Res. Manag 2008; 13 (3): 243–54.
7. Lynch C. Vaginal estrogen therapy for the treatment of atrophic vaginitis. J Womens Health (Larchmt) 2009; 18 (10): 1595–606.
8. Beard MK. Atrophic vaginitis. Can it be prevented as well as treated? Postgrad Med 1992; 91: 257.
9. Woods NF, Mitchell ES. Symptoms during the perimenopause: prevalence, severity, trajectory, and significance in women's lives. Am J Med 2005; 118 (Suppl. 12B): 14.
10. Castelo-Branco C, Cancelo MJ, Villero J et al. Management of post-menopausal vaginal atrophy and atrophic vaginitis. Maturitas 2005; 52 (Suppl. 1): S46.
11. Forsberg JG. A morphologist approach to vagine-age-related changes and estrogen sensitivity. Maturitas 1995; 22: 7–15.
12. Назарова Н.М., Межевитинова Е.А. Урогенитальные нарушения в постменопаузе: опыт применения препарата «Овестин». Гинекология. 2006 (Экстравыпуск): 9–10.
13. Larson PG, Platzs-Christiansen SS. The vaginal pH and leucocyte epithelial cell ratio during normal menstrual cycle. Eur J Obstet Gyn Reprod Biol 1990; 38: 39–41.
14. Castelo-Branco C, Cancelo MJ, Villero J et al. Management of post-menopausal vaginal atrophy and atrophic vaginitis. Maturitas 2005; 52 (Suppl. 1): S46.
15. Mehta A, Bachmann G. Vulvovaginal complaints. Clin Obstet Gynecol 2008; 51 (3): 549–55.
16. Suckling J, Lethaby A, Kennedy R. Local oestrogen for vaginal atrophy in postmenopausal women. J Suckling. Cochrane Database Syst Rev 2006; 18 (4): CD001500.
17. Балан В.Е. Принципы заместительной гормонотерапии урогенитальных расстройств. Cons. Med. 2003; 5 (7): 413–7.
18. Костава М.Н., Прилепская В.Н., Быковская О.В. Шеечно-влагалищная экосистема в постменопаузе и заместительная гормонотерапия. Гинекология. 2006 (Экстравыпуск): 6–8.
19. Lee JS, Ettinger B, Stanczyk FZ et al. Comparison of methods to measure low serum estradiol levels in postmenopausal women. J Clin Endocrinol Metab 2006; 91: 3791.
20. Балан В.Е. Клиническая картина, диагностика и лечение вагинальной атрофии в климактерии. Гинекология. 2009; 2 (11): 26–9.
21. The role of local vaginal estrogen for treatment of vaginal atrophy in postmenopausal women: 2007 position statement of The North American Menopause Society. Menopause 2007 (3 Pt. 1): 355–69.
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1. Spinillo A, Bernuzzi AM, Cevini C et al. The relationship of bacterial vaginosis, Candida and Trichomonas infection to symptomatic vaginitis in postmenopausal women attending a vaginitis clinic. Maturitas 1997; 27 (3): 253–60.
2. Балан В.Е. Принципы заместительной гормонотерапии урогенитальных расстройств. Гинекология. 2000; 2 (5): 140–2.
3. Сметник В.П. Руководство по климактерию. Под ред. В.П.Сметник, В.И.Кулакова. М.: МИА, 2001.
4. Nappi RE, Kokot-Kierepa M. Women's voices in the menopause: results from an international survey on vaginal atrophy. Maturitas 2010; 67: 233.
5. Bachmann GA, Nevadunsky NS. Diagnosis and treatment of atrophic vaginitis. Am Fam Physician 2000; 61: 3090.
6. Kao A et al. Dyspareunia in postmenopausal women: a critical review. Pain Res. Manag 2008; 13 (3): 243–54.
7. Lynch C. Vaginal estrogen therapy for the treatment of atrophic vaginitis. J Womens Health (Larchmt) 2009; 18 (10): 1595–606.
8. Beard MK. Atrophic vaginitis. Can it be prevented as well as treated? Postgrad Med 1992; 91: 257.
9. Woods NF, Mitchell ES. Symptoms during the perimenopause: prevalence, severity, trajectory, and significance in women's lives. Am J Med 2005; 118 (Suppl. 12B): 14.
10. Castelo-Branco C, Cancelo MJ, Villero J et al. Management of post-menopausal vaginal atrophy and atrophic vaginitis. Maturitas 2005; 52 (Suppl. 1): S46.
11. Forsberg JG. A morphologist approach to vagine-age-related changes and estrogen sensitivity. Maturitas 1995; 22: 7–15.
12. Назарова Н.М., Межевитинова Е.А. Урогенитальные нарушения в постменопаузе: опыт применения препарата «Овестин». Гинекология. 2006 (Экстравыпуск): 9–10.
13. Larson PG, Platzs-Christiansen SS. The vaginal pH and leucocyte epithelial cell ratio during normal menstrual cycle. Eur J Obstet Gyn Reprod Biol 1990; 38: 39–41.
14. Castelo-Branco C, Cancelo MJ, Villero J et al. Management of post-menopausal vaginal atrophy and atrophic vaginitis. Maturitas 2005; 52 (Suppl. 1): S46.
15. Mehta A, Bachmann G. Vulvovaginal complaints. Clin Obstet Gynecol 2008; 51 (3): 549–55.
16. Suckling J, Lethaby A, Kennedy R. Local oestrogen for vaginal atrophy in postmenopausal women. J Suckling. Cochrane Database Syst Rev 2006; 18 (4): CD001500.
17. Балан В.Е. Принципы заместительной гормонотерапии урогенитальных расстройств. Cons. Med. 2003; 5 (7): 413–7.
18. Костава М.Н., Прилепская В.Н., Быковская О.В. Шеечно-влагалищная экосистема в постменопаузе и заместительная гормонотерапия. Гинекология. 2006 (Экстравыпуск): 6–8.
19. Lee JS, Ettinger B, Stanczyk FZ et al. Comparison of methods to measure low serum estradiol levels in postmenopausal women. J Clin Endocrinol Metab 2006; 91: 3791.
20. Балан В.Е. Клиническая картина, диагностика и лечение вагинальной атрофии в климактерии. Гинекология. 2009; 2 (11): 26–9.
21. The role of local vaginal estrogen for treatment of vaginal atrophy in postmenopausal women: 2007 position statement of The North American Menopause Society. Menopause 2007 (3 Pt. 1): 355–69.
Авторы
В.Н.Прилепская, А.В.Ледина
ФГБУ Научный центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова
Минздрава России, Москва