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Локальное повреждение эндометрия как фактор, способствующий имплантации
Локальное повреждение эндометрия как фактор, способствующий имплантации
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Аннотация
В обзоре представлены данные литературы, показывающие взаимосвязь между исходами программы экстракорпорального оплодотворения и наличием местной воспалительной реакции в эндометрии. Отдельное внимание уделено обоснованию проведения биопсии эндометрия в качестве одного из возможных механизмов улучшения его рецепторной активности за счет повышения экспрессии ключевых молекул.
Ключевые слова: имплантация, воспаление, бесплодие, пайпель-биопсия, цитокины, иммунные клетки.
Key words: implantation, inflammation, infertility, Pipelle biopsy, cytokines, immune cells.
Ключевые слова: имплантация, воспаление, бесплодие, пайпель-биопсия, цитокины, иммунные клетки.
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Key words: implantation, inflammation, infertility, Pipelle biopsy, cytokines, immune cells.
Полный текст
Список литературы
1. Кетлинский С.А., Симбирцев А.С. Цитокины. СПб.: Фолиант, 2008.
2. Серов В.В., Пауков В.С. Воспаление: Руководство для врачей. М.: Медицина, 1995.
3. Сидельникова В.М., Сухих Г.Т. Невынашивание беременности. Руководство для практикующих врачей. М.: Медицинское информационное агентство, 2010.
4. Сидельникова В.М. Эндокринология беременности в норме и при патологии. 2-е изд. М.: МЕДпресс-информ, 2009.
5. Narvekar SA et al. Does local endometrial injury in the nontransfer cycle improve the IVF-ET outcome in the subsequent cycle in patients with previous unsuccessful IVF? A randomized controlled pilot study J Hum Reprod Sci 2010; 3 (1): 15−9.
6. Baum M et al. Does local injury to the endometrium before IVF cycle really affecttreatment outcome? Results of a randomized placebo controlled trial. Gynecol Endocrinol 2012; 28 (12): 933–6.
7. El-Toukhy T, Sunkara S, Khalaf Y. Local endometrial injury and IVF outcome: a systematic review and meta-analysis. Reprod Biomed Online 2012; 25 (4): 345–54.
8. Kalma Y et al. Endometrial biopsy-induced gene modulation: first evidence for the expression of bladder-transmembranal uroplakin Ib in human endometrium. Fertil Steril 2009; 91 (4): 1042–9.
9. Altmäe S et al. Endometrial gene expression analysis at the time of embryo implantation in women with unexplained infertility. Mol Hum Reprod 2010; 16 (3): 178–87.
10. Boomsma CM et al. Endometrial secretion analysis identifies a cytokine profile predictive of pregnancy in IVF. Hum Reprod 2009; 24 (6): 1427–35.
11. Raziel A et al. Favorable influence of local injury to the endometrium in intracytoplasmicintracytoplasmicsperm injection patients with high-order implantation failure. Fertil Steril 2007; 87 (1): 198–201.
12. Finn CA, Martin L. Endocrine control of the timing of endometrial sensitivity to a decidual stimulus. Biol Reprod 1972; 7 (1): 82–6.
13. Granot I, Gnainsky Y, Dekel N. Endometrial inflammation and effect on implantation improvement and pregnancy outcome. Reproduction 2012; 144 (6): 661−8.
14. Haider S, Knofler M. Human tumour necrosis factor: physiological and pathological roles in placenta and endometrium. Placenta 2009; 30 (2): 111–23.
15. Dekel N et al. Inflammation and Implantation. Am J Reprod Immunol 2010; 63 (1): 17–21.
16. Challis JR et al. Inflammation and pregnancy. Reprod Sci 2009; 16: 206–15.
17. Mor G et al. Inflammation and pregnancy: the role of the immune system at the implantation site. Ann N Y Acad Sci 2011; 1221: 80–7.
18. Karimzadeh MA, Ayazi Rozbahani M, Tabibnejad N. Endometrial local injury improves the pregnancy rate among recurrent implantation failure patients undergoing in vitro fertilisation/intra cytoplasmic sperm injection: a randomised clinical trial. Aust N Z J Obstet Gynaecol 2009; 49 (6): 677–80.
19. Barash A et al. Local injury of the endometriumdoubles the incidence of successful pregnancies in patients undergoing in-vitro fertilization. Fertil Steril 2003; 79 (6): 1317–22.
20. Gnainsky Y et al. Local injury of the endometrium induces an inflammatory response that promotes successful implantation. Fertil Steril 2010; 94 (6): 2030–6.
21. Loeb L. The experimental proof changes in the uterine decidua of guinea pig after mating. Zentralbl Allg Pathol 1907; 18: 563–5.
22. McIntire RH, Ganacias KG, Hunt JS. Programming of human monocytes by the uteroplacental environment. Reprod Sci 2008; 15 (5): 437–47.
23. Van Mourik MS, Heijnen CJ, Macklon NS. Embryonic implantation: cytokines, adhesion molecules, and immune cells in establishing an implantation environment. J Leukoc Biol 2009; 85 (1): 4–19.
24. Nagamatsu T, Schust DJ. The contribution of macrophages to normal and pathological pregnancies. Am J Reprod Immunol 2010; 63 (6): 460–71.
25. Johnson GA et al. Osteopontin: roles in implantation and placentation. Biol Reprod 2003; 69 (5): 1458–71.
26. El-Toukhy T et al. Outpatient hysteroscopy and subsequent IVF cycle outcome: a systematic review and meta-analysis. Reprod Biomed Online 2008; 16 (5): 712–9.
27. Renaud SJ, Graham CH. The role of macrophages in utero-placental interactions during normal and pathological pregnancy. Immunol Invest 2008; 37 (5): 535–64.
28. Rumack C. Diagnostic Ultrasound St Louis: Mosby, 2004.
29. Fest S et al. Trophoblast-macrophage interactions: a regulatory network for the protection of pregnancy. Am J Reprod Immunol 2007; 57 (1): 55–66.
30. Tuckerman E et al. Uterine natural killer cells in peri-implantation endometrium from women with repeated implantation failure after IVF. J Reprod Immunol 2010; 87: 60−6.
31. Wilczynski JR. Th1/Th2 cytokines balance – yin and yang of reproductive immunology. Eur J Obstet Gynecol Reprod Biol 2005; 122 (2): 136–43.
2. Серов В.В., Пауков В.С. Воспаление: Руководство для врачей. М.: Медицина, 1995.
3. Сидельникова В.М., Сухих Г.Т. Невынашивание беременности. Руководство для практикующих врачей. М.: Медицинское информационное агентство, 2010.
4. Сидельникова В.М. Эндокринология беременности в норме и при патологии. 2-е изд. М.: МЕДпресс-информ, 2009.
5. Narvekar SA et al. Does local endometrial injury in the nontransfer cycle improve the IVF-ET outcome in the subsequent cycle in patients with previous unsuccessful IVF? A randomized controlled pilot study J Hum Reprod Sci 2010; 3 (1): 15−9.
6. Baum M et al. Does local injury to the endometrium before IVF cycle really affecttreatment outcome? Results of a randomized placebo controlled trial. Gynecol Endocrinol 2012; 28 (12): 933–6.
7. El-Toukhy T, Sunkara S, Khalaf Y. Local endometrial injury and IVF outcome: a systematic review and meta-analysis. Reprod Biomed Online 2012; 25 (4): 345–54.
8. Kalma Y et al. Endometrial biopsy-induced gene modulation: first evidence for the expression of bladder-transmembranal uroplakin Ib in human endometrium. Fertil Steril 2009; 91 (4): 1042–9.
9. Altmäe S et al. Endometrial gene expression analysis at the time of embryo implantation in women with unexplained infertility. Mol Hum Reprod 2010; 16 (3): 178–87.
10. Boomsma CM et al. Endometrial secretion analysis identifies a cytokine profile predictive of pregnancy in IVF. Hum Reprod 2009; 24 (6): 1427–35.
11. Raziel A et al. Favorable influence of local injury to the endometrium in intracytoplasmicintracytoplasmicsperm injection patients with high-order implantation failure. Fertil Steril 2007; 87 (1): 198–201.
12. Finn CA, Martin L. Endocrine control of the timing of endometrial sensitivity to a decidual stimulus. Biol Reprod 1972; 7 (1): 82–6.
13. Granot I, Gnainsky Y, Dekel N. Endometrial inflammation and effect on implantation improvement and pregnancy outcome. Reproduction 2012; 144 (6): 661−8.
14. Haider S, Knofler M. Human tumour necrosis factor: physiological and pathological roles in placenta and endometrium. Placenta 2009; 30 (2): 111–23.
15. Dekel N et al. Inflammation and Implantation. Am J Reprod Immunol 2010; 63 (1): 17–21.
16. Challis JR et al. Inflammation and pregnancy. Reprod Sci 2009; 16: 206–15.
17. Mor G et al. Inflammation and pregnancy: the role of the immune system at the implantation site. Ann N Y Acad Sci 2011; 1221: 80–7.
18. Karimzadeh MA, Ayazi Rozbahani M, Tabibnejad N. Endometrial local injury improves the pregnancy rate among recurrent implantation failure patients undergoing in vitro fertilisation/intra cytoplasmic sperm injection: a randomised clinical trial. Aust N Z J Obstet Gynaecol 2009; 49 (6): 677–80.
19. Barash A et al. Local injury of the endometriumdoubles the incidence of successful pregnancies in patients undergoing in-vitro fertilization. Fertil Steril 2003; 79 (6): 1317–22.
20. Gnainsky Y et al. Local injury of the endometrium induces an inflammatory response that promotes successful implantation. Fertil Steril 2010; 94 (6): 2030–6.
21. Loeb L. The experimental proof changes in the uterine decidua of guinea pig after mating. Zentralbl Allg Pathol 1907; 18: 563–5.
22. McIntire RH, Ganacias KG, Hunt JS. Programming of human monocytes by the uteroplacental environment. Reprod Sci 2008; 15 (5): 437–47.
23. Van Mourik MS, Heijnen CJ, Macklon NS. Embryonic implantation: cytokines, adhesion molecules, and immune cells in establishing an implantation environment. J Leukoc Biol 2009; 85 (1): 4–19.
24. Nagamatsu T, Schust DJ. The contribution of macrophages to normal and pathological pregnancies. Am J Reprod Immunol 2010; 63 (6): 460–71.
25. Johnson GA et al. Osteopontin: roles in implantation and placentation. Biol Reprod 2003; 69 (5): 1458–71.
26. El-Toukhy T et al. Outpatient hysteroscopy and subsequent IVF cycle outcome: a systematic review and meta-analysis. Reprod Biomed Online 2008; 16 (5): 712–9.
27. Renaud SJ, Graham CH. The role of macrophages in utero-placental interactions during normal and pathological pregnancy. Immunol Invest 2008; 37 (5): 535–64.
28. Rumack C. Diagnostic Ultrasound St Louis: Mosby, 2004.
29. Fest S et al. Trophoblast-macrophage interactions: a regulatory network for the protection of pregnancy. Am J Reprod Immunol 2007; 57 (1): 55–66.
30. Tuckerman E et al. Uterine natural killer cells in peri-implantation endometrium from women with repeated implantation failure after IVF. J Reprod Immunol 2010; 87: 60−6.
31. Wilczynski JR. Th1/Th2 cytokines balance – yin and yang of reproductive immunology. Eur J Obstet Gynecol Reprod Biol 2005; 122 (2): 136–43.
2. Серов В.В., Пауков В.С. Воспаление: Руководство для врачей. М.: Медицина, 1995.
3. Сидельникова В.М., Сухих Г.Т. Невынашивание беременности. Руководство для практикующих врачей. М.: Медицинское информационное агентство, 2010.
4. Сидельникова В.М. Эндокринология беременности в норме и при патологии. 2-е изд. М.: МЕДпресс-информ, 2009.
5. Narvekar SA et al. Does local endometrial injury in the nontransfer cycle improve the IVF-ET outcome in the subsequent cycle in patients with previous unsuccessful IVF? A randomized controlled pilot study J Hum Reprod Sci 2010; 3 (1): 15−9.
6. Baum M et al. Does local injury to the endometrium before IVF cycle really affecttreatment outcome? Results of a randomized placebo controlled trial. Gynecol Endocrinol 2012; 28 (12): 933–6.
7. El-Toukhy T, Sunkara S, Khalaf Y. Local endometrial injury and IVF outcome: a systematic review and meta-analysis. Reprod Biomed Online 2012; 25 (4): 345–54.
8. Kalma Y et al. Endometrial biopsy-induced gene modulation: first evidence for the expression of bladder-transmembranal uroplakin Ib in human endometrium. Fertil Steril 2009; 91 (4): 1042–9.
9. Altmäe S et al. Endometrial gene expression analysis at the time of embryo implantation in women with unexplained infertility. Mol Hum Reprod 2010; 16 (3): 178–87.
10. Boomsma CM et al. Endometrial secretion analysis identifies a cytokine profile predictive of pregnancy in IVF. Hum Reprod 2009; 24 (6): 1427–35.
11. Raziel A et al. Favorable influence of local injury to the endometrium in intracytoplasmicintracytoplasmicsperm injection patients with high-order implantation failure. Fertil Steril 2007; 87 (1): 198–201.
12. Finn CA, Martin L. Endocrine control of the timing of endometrial sensitivity to a decidual stimulus. Biol Reprod 1972; 7 (1): 82–6.
13. Granot I, Gnainsky Y, Dekel N. Endometrial inflammation and effect on implantation improvement and pregnancy outcome. Reproduction 2012; 144 (6): 661−8.
14. Haider S, Knofler M. Human tumour necrosis factor: physiological and pathological roles in placenta and endometrium. Placenta 2009; 30 (2): 111–23.
15. Dekel N et al. Inflammation and Implantation. Am J Reprod Immunol 2010; 63 (1): 17–21.
16. Challis JR et al. Inflammation and pregnancy. Reprod Sci 2009; 16: 206–15.
17. Mor G et al. Inflammation and pregnancy: the role of the immune system at the implantation site. Ann N Y Acad Sci 2011; 1221: 80–7.
18. Karimzadeh MA, Ayazi Rozbahani M, Tabibnejad N. Endometrial local injury improves the pregnancy rate among recurrent implantation failure patients undergoing in vitro fertilisation/intra cytoplasmic sperm injection: a randomised clinical trial. Aust N Z J Obstet Gynaecol 2009; 49 (6): 677–80.
19. Barash A et al. Local injury of the endometriumdoubles the incidence of successful pregnancies in patients undergoing in-vitro fertilization. Fertil Steril 2003; 79 (6): 1317–22.
20. Gnainsky Y et al. Local injury of the endometrium induces an inflammatory response that promotes successful implantation. Fertil Steril 2010; 94 (6): 2030–6.
21. Loeb L. The experimental proof changes in the uterine decidua of guinea pig after mating. Zentralbl Allg Pathol 1907; 18: 563–5.
22. McIntire RH, Ganacias KG, Hunt JS. Programming of human monocytes by the uteroplacental environment. Reprod Sci 2008; 15 (5): 437–47.
23. Van Mourik MS, Heijnen CJ, Macklon NS. Embryonic implantation: cytokines, adhesion molecules, and immune cells in establishing an implantation environment. J Leukoc Biol 2009; 85 (1): 4–19.
24. Nagamatsu T, Schust DJ. The contribution of macrophages to normal and pathological pregnancies. Am J Reprod Immunol 2010; 63 (6): 460–71.
25. Johnson GA et al. Osteopontin: roles in implantation and placentation. Biol Reprod 2003; 69 (5): 1458–71.
26. El-Toukhy T et al. Outpatient hysteroscopy and subsequent IVF cycle outcome: a systematic review and meta-analysis. Reprod Biomed Online 2008; 16 (5): 712–9.
27. Renaud SJ, Graham CH. The role of macrophages in utero-placental interactions during normal and pathological pregnancy. Immunol Invest 2008; 37 (5): 535–64.
28. Rumack C. Diagnostic Ultrasound St Louis: Mosby, 2004.
29. Fest S et al. Trophoblast-macrophage interactions: a regulatory network for the protection of pregnancy. Am J Reprod Immunol 2007; 57 (1): 55–66.
30. Tuckerman E et al. Uterine natural killer cells in peri-implantation endometrium from women with repeated implantation failure after IVF. J Reprod Immunol 2010; 87: 60−6.
31. Wilczynski JR. Th1/Th2 cytokines balance – yin and yang of reproductive immunology. Eur J Obstet Gynecol Reprod Biol 2005; 122 (2): 136–43.
________________________________________________
2. Серов В.В., Пауков В.С. Воспаление: Руководство для врачей. М.: Медицина, 1995.
3. Сидельникова В.М., Сухих Г.Т. Невынашивание беременности. Руководство для практикующих врачей. М.: Медицинское информационное агентство, 2010.
4. Сидельникова В.М. Эндокринология беременности в норме и при патологии. 2-е изд. М.: МЕДпресс-информ, 2009.
5. Narvekar SA et al. Does local endometrial injury in the nontransfer cycle improve the IVF-ET outcome in the subsequent cycle in patients with previous unsuccessful IVF? A randomized controlled pilot study J Hum Reprod Sci 2010; 3 (1): 15−9.
6. Baum M et al. Does local injury to the endometrium before IVF cycle really affecttreatment outcome? Results of a randomized placebo controlled trial. Gynecol Endocrinol 2012; 28 (12): 933–6.
7. El-Toukhy T, Sunkara S, Khalaf Y. Local endometrial injury and IVF outcome: a systematic review and meta-analysis. Reprod Biomed Online 2012; 25 (4): 345–54.
8. Kalma Y et al. Endometrial biopsy-induced gene modulation: first evidence for the expression of bladder-transmembranal uroplakin Ib in human endometrium. Fertil Steril 2009; 91 (4): 1042–9.
9. Altmäe S et al. Endometrial gene expression analysis at the time of embryo implantation in women with unexplained infertility. Mol Hum Reprod 2010; 16 (3): 178–87.
10. Boomsma CM et al. Endometrial secretion analysis identifies a cytokine profile predictive of pregnancy in IVF. Hum Reprod 2009; 24 (6): 1427–35.
11. Raziel A et al. Favorable influence of local injury to the endometrium in intracytoplasmicintracytoplasmicsperm injection patients with high-order implantation failure. Fertil Steril 2007; 87 (1): 198–201.
12. Finn CA, Martin L. Endocrine control of the timing of endometrial sensitivity to a decidual stimulus. Biol Reprod 1972; 7 (1): 82–6.
13. Granot I, Gnainsky Y, Dekel N. Endometrial inflammation and effect on implantation improvement and pregnancy outcome. Reproduction 2012; 144 (6): 661−8.
14. Haider S, Knofler M. Human tumour necrosis factor: physiological and pathological roles in placenta and endometrium. Placenta 2009; 30 (2): 111–23.
15. Dekel N et al. Inflammation and Implantation. Am J Reprod Immunol 2010; 63 (1): 17–21.
16. Challis JR et al. Inflammation and pregnancy. Reprod Sci 2009; 16: 206–15.
17. Mor G et al. Inflammation and pregnancy: the role of the immune system at the implantation site. Ann N Y Acad Sci 2011; 1221: 80–7.
18. Karimzadeh MA, Ayazi Rozbahani M, Tabibnejad N. Endometrial local injury improves the pregnancy rate among recurrent implantation failure patients undergoing in vitro fertilisation/intra cytoplasmic sperm injection: a randomised clinical trial. Aust N Z J Obstet Gynaecol 2009; 49 (6): 677–80.
19. Barash A et al. Local injury of the endometriumdoubles the incidence of successful pregnancies in patients undergoing in-vitro fertilization. Fertil Steril 2003; 79 (6): 1317–22.
20. Gnainsky Y et al. Local injury of the endometrium induces an inflammatory response that promotes successful implantation. Fertil Steril 2010; 94 (6): 2030–6.
21. Loeb L. The experimental proof changes in the uterine decidua of guinea pig after mating. Zentralbl Allg Pathol 1907; 18: 563–5.
22. McIntire RH, Ganacias KG, Hunt JS. Programming of human monocytes by the uteroplacental environment. Reprod Sci 2008; 15 (5): 437–47.
23. Van Mourik MS, Heijnen CJ, Macklon NS. Embryonic implantation: cytokines, adhesion molecules, and immune cells in establishing an implantation environment. J Leukoc Biol 2009; 85 (1): 4–19.
24. Nagamatsu T, Schust DJ. The contribution of macrophages to normal and pathological pregnancies. Am J Reprod Immunol 2010; 63 (6): 460–71.
25. Johnson GA et al. Osteopontin: roles in implantation and placentation. Biol Reprod 2003; 69 (5): 1458–71.
26. El-Toukhy T et al. Outpatient hysteroscopy and subsequent IVF cycle outcome: a systematic review and meta-analysis. Reprod Biomed Online 2008; 16 (5): 712–9.
27. Renaud SJ, Graham CH. The role of macrophages in utero-placental interactions during normal and pathological pregnancy. Immunol Invest 2008; 37 (5): 535–64.
28. Rumack C. Diagnostic Ultrasound St Louis: Mosby, 2004.
29. Fest S et al. Trophoblast-macrophage interactions: a regulatory network for the protection of pregnancy. Am J Reprod Immunol 2007; 57 (1): 55–66.
30. Tuckerman E et al. Uterine natural killer cells in peri-implantation endometrium from women with repeated implantation failure after IVF. J Reprod Immunol 2010; 87: 60−6.
31. Wilczynski JR. Th1/Th2 cytokines balance – yin and yang of reproductive immunology. Eur J Obstet Gynecol Reprod Biol 2005; 122 (2): 136–43.
Авторы
М.А.Охрименко, В.Ю.Смольникова
ФГБУ Научный центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова Минздрава России, Москва
ФГБУ Научный центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова Минздрава России, Москва
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