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Полиморфизм генов рецепторов серотонина 5HT1A и 5HT2A в диагностике гиперактивного мочевого пузыря у женщин (результаты исследования)
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Аннотация
Поиск потенциальных предикторов диагностики гиперактивного мочевого пузыря инициировало изучение полиморфизма генов рецепторов серотонина 5HT1A и 5HT2A у женщин с гиперактивным мочевым пузырем. Согласно полученным результатам разницы по частотам аллелей HTR1A -1019 (1016) C>G (rs6295) и HTR2A 102 C>Т (S34S) (rs6313) между основной группой (с гиперактивным мочевым пузырем) и контрольной не было найдено.
Ключевые слова: гиперактивный мочевой пузырь, рецепторы серотонина 5HT1A и 5HT2A, полиморфизм генов.
Ключевые слова: гиперактивный мочевой пузырь, рецепторы серотонина 5HT1A и 5HT2A, полиморфизм генов.
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Search for potential predictors of diagnosis of overactive bladder led to the study of polymorphism of the serotonin 5HT1A receptor genes 5HT2A and women with overactive bladder. The results showed differences in frequencies of alleles HTR1A -1019 (1016) C>G (rs6295) and HTR2A 102 C>T (S34S) (rs6313) between the core group (with OAB) and the control group was found.
Key words: overactive bladder, serotonin 5HT1A receptors and 5HT2A, gene polymorphism.
Полный текст
Список литературы
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9. Strobel A, Gutknecht L, Rothe C et al. J Neural Transmission 2003; 110: 1445.
10. Kamata M, Suzuki A, Yoshida K et al. J Affect Disord 2011; 135 (1–3): 374–6; doi: 10.1016/j.jad.2011.08.027. Epub 2011. Genetic polymorphisms in the serotonergic system and symptom clusters of major depressive disorder. Health Administration Center, Yamagata University, Japan.
11. Lebe M, Hasenbring MI, Schmieder K et al. Association of serotonin-1A and -2A receptor promoter polymorphisms with depressive symptoms, functional recovery, and pain in patients 6months after lumbar disc surgery. Department of Medical Psychology and Medical Sociology, Faculty of Medicine, Ruhr University of Bochum, Bochum, Germany. Pain. 2012; pii: S0304-3959(12)00646-X. doi: 10.1016/j.pain.2012.11.017.
12. Moses-Kolko EL, Price JC, Shah N et al. Age, sex, and reproductive hormone effects on brain serotonin-1A and serotonin-2A receptor binding in a healthy population. Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA. Neuropsychopharmacology 2011; 36 (13): 2729–40; doi: 10.1038/npp.2011.163.
13. Markoutsaki T, Karantanos T, Gazouli M et al. 5-HT2A receptor gene polymorphisms and irritable bowel syndrome. 2nd Department of Gastroenterology, Evangelismos General Hospital, Athens, Greece. J Clin Gastroenterol 2011; 45 (6): 514-7; doi: 10.1097/MCG.0b013e318205e13b.
2. Owens MJ, Nemeroff CB Role of Serotonininthe Pathophysiology of Depression: Focuson the serotonin transporter. Clin Chem 1994; 40: 288–95.
3. Roth BL. Irving Page Lecture: 5-HT2A serotonin receptor biology: interacting proteins, kinases and paradoxical regulation. Neuropharmacology 2011; 61: 348–54.
4. Nebert DW. Polymorphisms in drug metabolizing enzymes: what is their clinical relevance and why do they exist. Am J Hum Genet 1997; 60: 265–71.
5. Lemonde S, Turecki G, Bakish D et al. J Neurosci 2003; 23: 8788.
6. Domschke K, Freitag CM, Kuhlenbumer G et al. Int J Neuropsychopharmacol 2004; 7 (2): 183.
7 Huang YY, Battistuzzi C, Oquendo MA et al. Int J Neuropsychopharmacol 2004; 7: 441.
8. Rothe C, Gutknecht L, Freitag C et al. Int J Neuropsychopharmacol 2004; 7: 189.
9. Strobel A, Gutknecht L, Rothe C et al. J Neural Transmission 2003; 110: 1445.
10. Kamata M, Suzuki A, Yoshida K et al. J Affect Disord 2011; 135 (1–3): 374–6; doi: 10.1016/j.jad.2011.08.027. Epub 2011. Genetic polymorphisms in the serotonergic system and symptom clusters of major depressive disorder. Health Administration Center, Yamagata University, Japan.
11. Lebe M, Hasenbring MI, Schmieder K et al. Association of serotonin-1A and -2A receptor promoter polymorphisms with depressive symptoms, functional recovery, and pain in patients 6months after lumbar disc surgery. Department of Medical Psychology and Medical Sociology, Faculty of Medicine, Ruhr University of Bochum, Bochum, Germany. Pain. 2012; pii: S0304-3959(12)00646-X. doi: 10.1016/j.pain.2012.11.017.
12. Moses-Kolko EL, Price JC, Shah N et al. Age, sex, and reproductive hormone effects on brain serotonin-1A and serotonin-2A receptor binding in a healthy population. Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA. Neuropsychopharmacology 2011; 36 (13): 2729–40; doi: 10.1038/npp.2011.163.
13. Markoutsaki T, Karantanos T, Gazouli M et al. 5-HT2A receptor gene polymorphisms and irritable bowel syndrome. 2nd Department of Gastroenterology, Evangelismos General Hospital, Athens, Greece. J Clin Gastroenterol 2011; 45 (6): 514-7; doi: 10.1097/MCG.0b013e318205e13b.
________________________________________________
1. Turecki G. Dissecting the suicide phenotype: the role of impulsive-aggressive behaviours. J Psychiatry Neurosci 2005; 30 (6): 398–408.
2. Owens MJ, Nemeroff CB Role of Serotonininthe Pathophysiology of Depression: Focuson the serotonin transporter. Clin Chem 1994; 40: 288–95.
3. Roth BL. Irving Page Lecture: 5-HT2A serotonin receptor biology: interacting proteins, kinases and paradoxical regulation. Neuropharmacology 2011; 61: 348–54.
4. Nebert DW. Polymorphisms in drug metabolizing enzymes: what is their clinical relevance and why do they exist. Am J Hum Genet 1997; 60: 265–71.
5. Lemonde S, Turecki G, Bakish D et al. J Neurosci 2003; 23: 8788.
6. Domschke K, Freitag CM, Kuhlenbumer G et al. Int J Neuropsychopharmacol 2004; 7 (2): 183.
7 Huang YY, Battistuzzi C, Oquendo MA et al. Int J Neuropsychopharmacol 2004; 7: 441.
8. Rothe C, Gutknecht L, Freitag C et al. Int J Neuropsychopharmacol 2004; 7: 189.
9. Strobel A, Gutknecht L, Rothe C et al. J Neural Transmission 2003; 110: 1445.
10. Kamata M, Suzuki A, Yoshida K et al. J Affect Disord 2011; 135 (1–3): 374–6; doi: 10.1016/j.jad.2011.08.027. Epub 2011. Genetic polymorphisms in the serotonergic system and symptom clusters of major depressive disorder. Health Administration Center, Yamagata University, Japan.
11. Lebe M, Hasenbring MI, Schmieder K et al. Association of serotonin-1A and -2A receptor promoter polymorphisms with depressive symptoms, functional recovery, and pain in patients 6months after lumbar disc surgery. Department of Medical Psychology and Medical Sociology, Faculty of Medicine, Ruhr University of Bochum, Bochum, Germany. Pain. 2012; pii: S0304-3959(12)00646-X. doi: 10.1016/j.pain.2012.11.017.
12. Moses-Kolko EL, Price JC, Shah N et al. Age, sex, and reproductive hormone effects on brain serotonin-1A and serotonin-2A receptor binding in a healthy population. Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA. Neuropsychopharmacology 2011; 36 (13): 2729–40; doi: 10.1038/npp.2011.163.
13. Markoutsaki T, Karantanos T, Gazouli M et al. 5-HT2A receptor gene polymorphisms and irritable bowel syndrome. 2nd Department of Gastroenterology, Evangelismos General Hospital, Athens, Greece. J Clin Gastroenterol 2011; 45 (6): 514-7; doi: 10.1097/MCG.0b013e318205e13b.
Авторы
Ф.Н.Махмеджанова1, И.А.Аполихина1, 2
1. ФГБУ Научный центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова Минздрава России, Москва;
2. ГБОУ ВПО Первый Московский государственный медицинский университет им. И.М.Сеченова Минздрава России
1. ФГБУ Научный центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова Минздрава России, Москва;
2. ГБОУ ВПО Первый Московский государственный медицинский университет им. И.М.Сеченова Минздрава России
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F.N.Makhmejanova, I.A.Apolikhina
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