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Биохимические маркеры оценки овариального резерва (обзор литературы)
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Аннотация
Проведен систематический анализ современных исследований, посвященных оценке овариального резерва. Отсутствие классификации и систематизации методов определения овариального резерва, разнородность применяемых методов и различия в оценках исхода свидетельствуют о множестве нерешенных задач в данной проблеме.
Ключевые слова: овариальный резерв, фертильность, маркеры оценки овариального резерва.
Ключевые слова: овариальный резерв, фертильность, маркеры оценки овариального резерва.
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A systematic analysis of data available in the current literature to assess ovarian reserve. Made an attempt to assess the specificity and accuracy of these markers and stress tests depending on epiopatogeneticheskih factors leading to a decrease in ovarian reserve.
Key words: ovarian reserve, fertility, evaluation markers of ovarian reserve.
Полный текст
Список литературы
1. Kyrou D, Kolibianakis E, Venetis CA et al. How to improve the probability of pregnancy in poor responders undergoing in vitro fertilization: a systematic review and meta-analysis. Fertil Steril 2009; 91 (2): 749–66.
2. Loutradis D, Vomvolaki E, Drakakis P. Poor responder protocols for in-vitro fertilization: 0ptions and results. Curr Opin Obstet Gynecol 2008;
20 (4): 374–8.
3. Ferraretti AP, la Marca A, Fauser BC et al. ESHRE working group on Poor Ovarian Response Definition. Hum Reprod 2011; 26 (7): 1616–24.
4. Broer SL, Eijkemans MJ, Scheffer GJ et al. J Clin Endocrinol Metab 2011; 96 (8): 2532–9.
5. Pandian Z, McTavish AR, Aucott L et al. Intervention for poor responders to controlled ovarian hyper stimulation in IVF. Cochrane Database Syst Rev 2010; 1: CD004379; doi: 10.1002/14651858. CD004379.pub3.
6. Check JH. Understanding the physiology of folliculogenesis serves as the foundation for perfecting diagnosis and treatment of ovulatory defects. Clin Exp Obstet Gynecol 2012; 39 (3): 273–9.
7. Боярский К.Ю. Факторы, определяющие овариальный резерв. Журн. акушерства и женских болезней. 2009. Вып. 2; с. 65–71.
8. Benedict MD, Missmer SA, Ferguson KK et al. Secondhand tobacco smoke exposure is associated with prolactin but not thyroid stimulating hormone among nonsmoking women seeking in vitro fertilization. Environ Toxicol Pharmacol 2012; 34 (3): 761–7.
9. Benaglia L, Somigliana E, Vighi V et al. Rate of severe ovarian damage following surgery for endometriomas. Hum Reprod 2010; 25 (3): 678–82.
10. Blanchette H. Obstetric performance of patients after oocyte donation. Am J Obstet Gynecol 1993; 168 (6; Pt l): 1803–7.
11. Blanchette H. Obstetric performance of patients after oocyte donation. Am J Obstet Gynecol 1994; 170 (1; Pt l): 1800–2.
12. Biacchiardi CP, Piane LD, Camanni M et al. Laparoscopic stripping of endometriomas negatively affects ovarian follicular reserve even if performed by experienced surgeons. Reprod Biomed Online 2011; 23 (6): 740–6.
13. Bouwsma EV, Hesley GK, Woodrum DA et al.Comparing focused ultrasound and uterine artery embolization for uterine fibroids-rationale and design of the Fibroid Interventions: reducing symptoms today and tomorrow (FIRSTT) trial. Fertil Steril 2011; 96 (3): 704–10.
14. Broekmans FJ, Faddy MJ, Scheffer G, te Velde ER. Antral follicle counts are related to age at natural fertility loss and age at menopause.
15. Biacchiardi CP, Piane LD, Camanni M et al. Laparoscopic stripping of endometriomas negatively affects ovarian follicular reserve even if performed by experienced surgeons. Reprod Biomed Online 2011; 23 (6): 740–6.
16. Celik HG, Dogan E, Okyay E et al. Effect of laparoscopic excision of endometriomas on ovarian reserve: serial changes in the serum antimüllerian hormone levels. Fertil Steril 2012; 97 (6): 1472–8.
17. Kunt C, Ozaksit G, Keskin KR et al. Anti-Mullerian hormone is a better marker than inhibin B, follicle stimulating hormone, estradiol or antral follicle count in predicting the outcome of in vitro fertilization. Arch Gynecol Obstet 2011; 283 (6): 1415–21.
18. Fong SL, Lugtenburg PJ, Schipper I et al. Anti-müllerian hormone as a marker of ovarian function in women after chemotherapy and radiotherapy for haematological malignancies. Hum Reprod 2008; 23 (3): 674–8.
19. Dillon KE, Sammel MD, Ginsberg JP et al. Pregnancy after cancer: Results from a prospective cohort study of cancer survivors. Pediatr Blood Cancer 2013; doi: 10.1002/pbc.24701.
20. Merhi Z, Zapantis A, Berger DS, Jindal SK. Determining an anti-mullerian hormone cutoff level to predict clinical pregnancy following in vitro fertilization in women with severely diminished ovarian reserve. J Assist Reprod Genet 2013.
21. Stangel-Wojcikiewicz K, Zdebik A, Jach R et al. Hormone replacement therapy regimens in chemotherapy-induced premature ovarian failure and the subsequent correction of hormone levels. Neuro Endocrinol Lett 2012; 33 (7): 697–702.
22. La Marca A, Argento C, Sighinolfi G et al. Possibilities and limits of ovarian reserve testing in ART. Curr Pharm Biotechnol 2012; 13 (3): 398–408.
23. De Carvalho BR, Rosa e Silva AC, Rosa e Silva JC et al. Ovarian reserve evaluation: state of the art. J Assist Reprod Genet 2008; 25 (7): 311–22.
24. Gallot V, Berwanger da Silva AL, Genro V et al. Antral follicle responsiveness to follicle-stimulating hormone administration assessed by the Follicular Output RaTe (FORT) may predict in vitro fertilization-embryo transfer outcome. Hum Reprod 2012; 27 (4): 1066–72.
25. Sunj M, Canic T, Baldani DP et al. Does unilateral laparoscopic diathermy adjusted to ovarian volume increase the chances of ovulation in women with polycystic ovary syndrome? Hum Reprod 2013; 28 (9): 2417–24.
26. Carmina E, Campagna AM, Lobo RA. Emergence of ovulatory cycles with aging in women with polycystic ovary syndrome (PCOS) alters the trajectory of cardiovascular and metabolic risk factors. Hum Reprod 2013; 28 (8): 2245–52.
27. Chiamchanya C, Visutakul P, Gumnarai N, Su-angkawatin W. Preimplantation genetic screening (PGS) in infertile female age > or = 35 years by fluorescence in situ hybridization of chromosome 13, 18, 21, X and Y. J Med Assoc Thai 2008; 91 (11): 1644–50.
28. Ahmed WA, Tsutsumi M, Nakata S et al. A functional variation in the hypocretin neuropeptide precursor gene may be associated with obstructive sleep apnea syndrome in Japan. Laryngoscope 2012; 122 (4): 925–9.
29. Haadsma ML, Groen H, Fidler V et al. The predictivevalue of ovarian reserve tests for miscarriage in a population of subfertile ovulatory women. Hum Reprod 2009; 24 (3): 546–52.
30. Butts SF, Ratcliffe S, Dokras A, Seifer DB. Diagnosis and treatment of diminished ovarian reserve in assisted reproductive technology cycles of women up to age 40 years: the role of insurance mandates. Fertil Steril 2013; 99 (2): 382–8.
31. Jersus J, Woodruff T. Preservation of fertility in patients with cancer. N Engl J Med 2009; 360: 902–11.
2. Loutradis D, Vomvolaki E, Drakakis P. Poor responder protocols for in-vitro fertilization: 0ptions and results. Curr Opin Obstet Gynecol 2008;
20 (4): 374–8.
3. Ferraretti AP, la Marca A, Fauser BC et al. ESHRE working group on Poor Ovarian Response Definition. Hum Reprod 2011; 26 (7): 1616–24.
4. Broer SL, Eijkemans MJ, Scheffer GJ et al. J Clin Endocrinol Metab 2011; 96 (8): 2532–9.
5. Pandian Z, McTavish AR, Aucott L et al. Intervention for poor responders to controlled ovarian hyper stimulation in IVF. Cochrane Database Syst Rev 2010; 1: CD004379; doi: 10.1002/14651858. CD004379.pub3.
6. Check JH. Understanding the physiology of folliculogenesis serves as the foundation for perfecting diagnosis and treatment of ovulatory defects. Clin Exp Obstet Gynecol 2012; 39 (3): 273–9.
7. Боярский К.Ю. Факторы, определяющие овариальный резерв. Журн. акушерства и женских болезней. 2009. Вып. 2; с. 65–71.
8. Benedict MD, Missmer SA, Ferguson KK et al. Secondhand tobacco smoke exposure is associated with prolactin but not thyroid stimulating hormone among nonsmoking women seeking in vitro fertilization. Environ Toxicol Pharmacol 2012; 34 (3): 761–7.
9. Benaglia L, Somigliana E, Vighi V et al. Rate of severe ovarian damage following surgery for endometriomas. Hum Reprod 2010; 25 (3): 678–82.
10. Blanchette H. Obstetric performance of patients after oocyte donation. Am J Obstet Gynecol 1993; 168 (6; Pt l): 1803–7.
11. Blanchette H. Obstetric performance of patients after oocyte donation. Am J Obstet Gynecol 1994; 170 (1; Pt l): 1800–2.
12. Biacchiardi CP, Piane LD, Camanni M et al. Laparoscopic stripping of endometriomas negatively affects ovarian follicular reserve even if performed by experienced surgeons. Reprod Biomed Online 2011; 23 (6): 740–6.
13. Bouwsma EV, Hesley GK, Woodrum DA et al.Comparing focused ultrasound and uterine artery embolization for uterine fibroids-rationale and design of the Fibroid Interventions: reducing symptoms today and tomorrow (FIRSTT) trial. Fertil Steril 2011; 96 (3): 704–10.
14. Broekmans FJ, Faddy MJ, Scheffer G, te Velde ER. Antral follicle counts are related to age at natural fertility loss and age at menopause.
15. Biacchiardi CP, Piane LD, Camanni M et al. Laparoscopic stripping of endometriomas negatively affects ovarian follicular reserve even if performed by experienced surgeons. Reprod Biomed Online 2011; 23 (6): 740–6.
16. Celik HG, Dogan E, Okyay E et al. Effect of laparoscopic excision of endometriomas on ovarian reserve: serial changes in the serum antimüllerian hormone levels. Fertil Steril 2012; 97 (6): 1472–8.
17. Kunt C, Ozaksit G, Keskin KR et al. Anti-Mullerian hormone is a better marker than inhibin B, follicle stimulating hormone, estradiol or antral follicle count in predicting the outcome of in vitro fertilization. Arch Gynecol Obstet 2011; 283 (6): 1415–21.
18. Fong SL, Lugtenburg PJ, Schipper I et al. Anti-müllerian hormone as a marker of ovarian function in women after chemotherapy and radiotherapy for haematological malignancies. Hum Reprod 2008; 23 (3): 674–8.
19. Dillon KE, Sammel MD, Ginsberg JP et al. Pregnancy after cancer: Results from a prospective cohort study of cancer survivors. Pediatr Blood Cancer 2013; doi: 10.1002/pbc.24701.
20. Merhi Z, Zapantis A, Berger DS, Jindal SK. Determining an anti-mullerian hormone cutoff level to predict clinical pregnancy following in vitro fertilization in women with severely diminished ovarian reserve. J Assist Reprod Genet 2013.
21. Stangel-Wojcikiewicz K, Zdebik A, Jach R et al. Hormone replacement therapy regimens in chemotherapy-induced premature ovarian failure and the subsequent correction of hormone levels. Neuro Endocrinol Lett 2012; 33 (7): 697–702.
22. La Marca A, Argento C, Sighinolfi G et al. Possibilities and limits of ovarian reserve testing in ART. Curr Pharm Biotechnol 2012; 13 (3): 398–408.
23. De Carvalho BR, Rosa e Silva AC, Rosa e Silva JC et al. Ovarian reserve evaluation: state of the art. J Assist Reprod Genet 2008; 25 (7): 311–22.
24. Gallot V, Berwanger da Silva AL, Genro V et al. Antral follicle responsiveness to follicle-stimulating hormone administration assessed by the Follicular Output RaTe (FORT) may predict in vitro fertilization-embryo transfer outcome. Hum Reprod 2012; 27 (4): 1066–72.
25. Sunj M, Canic T, Baldani DP et al. Does unilateral laparoscopic diathermy adjusted to ovarian volume increase the chances of ovulation in women with polycystic ovary syndrome? Hum Reprod 2013; 28 (9): 2417–24.
26. Carmina E, Campagna AM, Lobo RA. Emergence of ovulatory cycles with aging in women with polycystic ovary syndrome (PCOS) alters the trajectory of cardiovascular and metabolic risk factors. Hum Reprod 2013; 28 (8): 2245–52.
27. Chiamchanya C, Visutakul P, Gumnarai N, Su-angkawatin W. Preimplantation genetic screening (PGS) in infertile female age > or = 35 years by fluorescence in situ hybridization of chromosome 13, 18, 21, X and Y. J Med Assoc Thai 2008; 91 (11): 1644–50.
28. Ahmed WA, Tsutsumi M, Nakata S et al. A functional variation in the hypocretin neuropeptide precursor gene may be associated with obstructive sleep apnea syndrome in Japan. Laryngoscope 2012; 122 (4): 925–9.
29. Haadsma ML, Groen H, Fidler V et al. The predictivevalue of ovarian reserve tests for miscarriage in a population of subfertile ovulatory women. Hum Reprod 2009; 24 (3): 546–52.
30. Butts SF, Ratcliffe S, Dokras A, Seifer DB. Diagnosis and treatment of diminished ovarian reserve in assisted reproductive technology cycles of women up to age 40 years: the role of insurance mandates. Fertil Steril 2013; 99 (2): 382–8.
31. Jersus J, Woodruff T. Preservation of fertility in patients with cancer. N Engl J Med 2009; 360: 902–11.
________________________________________________
1. Kyrou D, Kolibianakis E, Venetis CA et al. How to improve the probability of pregnancy in poor responders undergoing in vitro fertilization: a systematic review and meta-analysis. Fertil Steril 2009; 91 (2): 749–66.
2. Loutradis D, Vomvolaki E, Drakakis P. Poor responder protocols for in-vitro fertilization: 0ptions and results. Curr Opin Obstet Gynecol 2008;
20 (4): 374–8.
3. Ferraretti AP, la Marca A, Fauser BC et al. ESHRE working group on Poor Ovarian Response Definition. Hum Reprod 2011; 26 (7): 1616–24.
4. Broer SL, Eijkemans MJ, Scheffer GJ et al. J Clin Endocrinol Metab 2011; 96 (8): 2532–9.
5. Pandian Z, McTavish AR, Aucott L et al. Intervention for poor responders to controlled ovarian hyper stimulation in IVF. Cochrane Database Syst Rev 2010; 1: CD004379; doi: 10.1002/14651858. CD004379.pub3.
6. Check JH. Understanding the physiology of folliculogenesis serves as the foundation for perfecting diagnosis and treatment of ovulatory defects. Clin Exp Obstet Gynecol 2012; 39 (3): 273–9.
7. Боярский К.Ю. Факторы, определяющие овариальный резерв. Журн. акушерства и женских болезней. 2009. Вып. 2; с. 65–71.
8. Benedict MD, Missmer SA, Ferguson KK et al. Secondhand tobacco smoke exposure is associated with prolactin but not thyroid stimulating hormone among nonsmoking women seeking in vitro fertilization. Environ Toxicol Pharmacol 2012; 34 (3): 761–7.
9. Benaglia L, Somigliana E, Vighi V et al. Rate of severe ovarian damage following surgery for endometriomas. Hum Reprod 2010; 25 (3): 678–82.
10. Blanchette H. Obstetric performance of patients after oocyte donation. Am J Obstet Gynecol 1993; 168 (6; Pt l): 1803–7.
11. Blanchette H. Obstetric performance of patients after oocyte donation. Am J Obstet Gynecol 1994; 170 (1; Pt l): 1800–2.
12. Biacchiardi CP, Piane LD, Camanni M et al. Laparoscopic stripping of endometriomas negatively affects ovarian follicular reserve even if performed by experienced surgeons. Reprod Biomed Online 2011; 23 (6): 740–6.
13. Bouwsma EV, Hesley GK, Woodrum DA et al.Comparing focused ultrasound and uterine artery embolization for uterine fibroids-rationale and design of the Fibroid Interventions: reducing symptoms today and tomorrow (FIRSTT) trial. Fertil Steril 2011; 96 (3): 704–10.
14. Broekmans FJ, Faddy MJ, Scheffer G, te Velde ER. Antral follicle counts are related to age at natural fertility loss and age at menopause.
15. Biacchiardi CP, Piane LD, Camanni M et al. Laparoscopic stripping of endometriomas negatively affects ovarian follicular reserve even if performed by experienced surgeons. Reprod Biomed Online 2011; 23 (6): 740–6.
16. Celik HG, Dogan E, Okyay E et al. Effect of laparoscopic excision of endometriomas on ovarian reserve: serial changes in the serum antimüllerian hormone levels. Fertil Steril 2012; 97 (6): 1472–8.
17. Kunt C, Ozaksit G, Keskin KR et al. Anti-Mullerian hormone is a better marker than inhibin B, follicle stimulating hormone, estradiol or antral follicle count in predicting the outcome of in vitro fertilization. Arch Gynecol Obstet 2011; 283 (6): 1415–21.
18. Fong SL, Lugtenburg PJ, Schipper I et al. Anti-müllerian hormone as a marker of ovarian function in women after chemotherapy and radiotherapy for haematological malignancies. Hum Reprod 2008; 23 (3): 674–8.
19. Dillon KE, Sammel MD, Ginsberg JP et al. Pregnancy after cancer: Results from a prospective cohort study of cancer survivors. Pediatr Blood Cancer 2013; doi: 10.1002/pbc.24701.
20. Merhi Z, Zapantis A, Berger DS, Jindal SK. Determining an anti-mullerian hormone cutoff level to predict clinical pregnancy following in vitro fertilization in women with severely diminished ovarian reserve. J Assist Reprod Genet 2013.
21. Stangel-Wojcikiewicz K, Zdebik A, Jach R et al. Hormone replacement therapy regimens in chemotherapy-induced premature ovarian failure and the subsequent correction of hormone levels. Neuro Endocrinol Lett 2012; 33 (7): 697–702.
22. La Marca A, Argento C, Sighinolfi G et al. Possibilities and limits of ovarian reserve testing in ART. Curr Pharm Biotechnol 2012; 13 (3): 398–408.
23. De Carvalho BR, Rosa e Silva AC, Rosa e Silva JC et al. Ovarian reserve evaluation: state of the art. J Assist Reprod Genet 2008; 25 (7): 311–22.
24. Gallot V, Berwanger da Silva AL, Genro V et al. Antral follicle responsiveness to follicle-stimulating hormone administration assessed by the Follicular Output RaTe (FORT) may predict in vitro fertilization-embryo transfer outcome. Hum Reprod 2012; 27 (4): 1066–72.
25. Sunj M, Canic T, Baldani DP et al. Does unilateral laparoscopic diathermy adjusted to ovarian volume increase the chances of ovulation in women with polycystic ovary syndrome? Hum Reprod 2013; 28 (9): 2417–24.
26. Carmina E, Campagna AM, Lobo RA. Emergence of ovulatory cycles with aging in women with polycystic ovary syndrome (PCOS) alters the trajectory of cardiovascular and metabolic risk factors. Hum Reprod 2013; 28 (8): 2245–52.
27. Chiamchanya C, Visutakul P, Gumnarai N, Su-angkawatin W. Preimplantation genetic screening (PGS) in infertile female age > or = 35 years by fluorescence in situ hybridization of chromosome 13, 18, 21, X and Y. J Med Assoc Thai 2008; 91 (11): 1644–50.
28. Ahmed WA, Tsutsumi M, Nakata S et al. A functional variation in the hypocretin neuropeptide precursor gene may be associated with obstructive sleep apnea syndrome in Japan. Laryngoscope 2012; 122 (4): 925–9.
29. Haadsma ML, Groen H, Fidler V et al. The predictivevalue of ovarian reserve tests for miscarriage in a population of subfertile ovulatory women. Hum Reprod 2009; 24 (3): 546–52.
30. Butts SF, Ratcliffe S, Dokras A, Seifer DB. Diagnosis and treatment of diminished ovarian reserve in assisted reproductive technology cycles of women up to age 40 years: the role of insurance mandates. Fertil Steril 2013; 99 (2): 382–8.
31. Jersus J, Woodruff T. Preservation of fertility in patients with cancer. N Engl J Med 2009; 360: 902–11.
Авторы
А.С.Гаспаров, Е.Д.Дубинская, Д.С.Титов
Кафедра акушерства, гинекологии и репродуктивной медицины ФПКМР ФГБОУ ВПО Российский университет дружбы народов, Москва
Кафедра акушерства, гинекологии и репродуктивной медицины ФПКМР ФГБОУ ВПО Российский университет дружбы народов, Москва
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A.S.Gasparov, E.D.Dubinskaya, D.S.Titov
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