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Влияние диеногеста на морфофункциональное состояние эндометрия при наружном генитальном эндометриозе
Влияние диеногеста на морфофункциональное состояние эндометрия при наружном генитальном эндометриозе
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Аннотация
В работе исследовалось влияние диеногеста на морфофункциональное состояние эндометрия у больных с наружным генитальным эндометриозом. Показано, что диеногест эффективно купирует болевой синдром у больных с наружным генитальным эндометриозом и улучшает морфофункциональное состояние эндометрия, купирует проявления воспаления в слизистой оболочке матки.
Ключевые слова: диеногест, наружный генитальный эндометриоз, эндометрий.
Key words: dienogest, external genital endometriosis, the endometrium.
Ключевые слова: диеногест, наружный генитальный эндометриоз, эндометрий.
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Key words: dienogest, external genital endometriosis, the endometrium.
Полный текст
Список литературы
1. Сотникова Л.С., Удут Е.Н., Насырова Р.Ф., Тонких О.С. Современная терапия эндометриоза. Опыт применения визанны. Проблемы репродукции. 2012; 6: 34–9.
2. Belaisch J, Allart JP. Endometriosis and surviving adolescence. Gynecol Obstet Fertil 2006; 34 (3): 242–7.
3. Frackiewicz EJ. Endometriosis: an overview of the disease and its treatment. J Am Pharm Assoc (Wash) 2000; 40 (5): 645–57.
4. Barbieri RL, Missmer S. Endometriosis and infertility: a cause-effect relationship? Ann N Y Acad Sci 2002; 95 (5): 23–33; discussion 34–6: 396–406.
5. Buletti С et al. J Assist Reprod Genet 2010; 27: 441–7.
6. Allaire C. Endometriosis and infertility: a review. J Reprod Med 2006; 51 (3): 164–8.
7. Garrido N, Navarro J, Garcia-Velasco J et al. The endometrium versus embryonic quality in endometriosis-related infertility. Hum Reprod Update 2002; 8 (1): 95–103.
8. De Ziegler D, Borghese B, Chapron C. Endometriosis and infertility: pathophysiology and management. Lancet 2010; 376: 730–8.
9. Khoufache K et al. Anomalies in the inflammatory response in endometriosis and possible consequences: a review. Minerva Endocrinol 2012; 37 (1): 75–92.
10. Баскаков В.П. Клиника и лечение эндометриоза. Л.: Медицина, 1990.
11. Matalliotakis IM, Athanassakis I, Goumenou AG et al. The possible anti-inflammatory role of circulating human leukocyte antigen levels in women with еndometriosis after treatment with danazol and leuprorelin acetate depot. Mediators Inflamm 2001; 10 (2): 75–80.
12. Brown J, Farqufar C. Endometriosis: an overview of Cochrane Reviews. Cochrane Database Syst Rev 2014; 10 (3): CD009590.
13. Oettel M, Carol W, Elger W et al. A 19-norprogestin without 17a-ethinyl group II: dienogest from a pharmacodynamic point of view. Drugs Today 1995; 31: 517–36.
14. McCormac Dienogest (review). Drugs 2010; 70 (16): 2073–88.
15. Nakamura et al. Eur J Pharmacol 1999; 386: 33–40.
16. Harada et al. Future science group, Women’s Health. 2010; 6 (1): 27–35.
17. Johnson NP, Hummelshoj L. Consensus on current management of endometriosis. Hum Reprod 2013; 28 (6): 1152–68.
18. Shimizu Y, Mita S, et al. Dienogest, a synthetic progestin, inhibits prostaglandin E2 production and aromatase expression by human endometrial epithelial cells in a spheroid culture system. Steroids 2011; 76: 60–7.
19. Strowitzki T, Marr J, Gerlinger C et al. Dienogest is as effective as leuprolide acetate in treating the painful symptoms of endometriosis: a 24-week, randomized, multicenter, opel-label trial. Hum Reprod 2010; 25 (3): 633–41.
2. Belaisch J, Allart JP. Endometriosis and surviving adolescence. Gynecol Obstet Fertil 2006; 34 (3): 242–7.
3. Frackiewicz EJ. Endometriosis: an overview of the disease and its treatment. J Am Pharm Assoc (Wash) 2000; 40 (5): 645–57.
4. Barbieri RL, Missmer S. Endometriosis and infertility: a cause-effect relationship? Ann N Y Acad Sci 2002; 95 (5): 23–33; discussion 34–6: 396–406.
5. Buletti С et al. J Assist Reprod Genet 2010; 27: 441–7.
6. Allaire C. Endometriosis and infertility: a review. J Reprod Med 2006; 51 (3): 164–8.
7. Garrido N, Navarro J, Garcia-Velasco J et al. The endometrium versus embryonic quality in endometriosis-related infertility. Hum Reprod Update 2002; 8 (1): 95–103.
8. De Ziegler D, Borghese B, Chapron C. Endometriosis and infertility: pathophysiology and management. Lancet 2010; 376: 730–8.
9. Khoufache K et al. Anomalies in the inflammatory response in endometriosis and possible consequences: a review. Minerva Endocrinol 2012; 37 (1): 75–92.
10. Баскаков В.П. Клиника и лечение эндометриоза. Л.: Медицина, 1990.
11. Matalliotakis IM, Athanassakis I, Goumenou AG et al. The possible anti-inflammatory role of circulating human leukocyte antigen levels in women with еndometriosis after treatment with danazol and leuprorelin acetate depot. Mediators Inflamm 2001; 10 (2): 75–80.
12. Brown J, Farqufar C. Endometriosis: an overview of Cochrane Reviews. Cochrane Database Syst Rev 2014; 10 (3): CD009590.
13. Oettel M, Carol W, Elger W et al. A 19-norprogestin without 17a-ethinyl group II: dienogest from a pharmacodynamic point of view. Drugs Today 1995; 31: 517–36.
14. McCormac Dienogest (review). Drugs 2010; 70 (16): 2073–88.
15. Nakamura et al. Eur J Pharmacol 1999; 386: 33–40.
16. Harada et al. Future science group, Women’s Health. 2010; 6 (1): 27–35.
17. Johnson NP, Hummelshoj L. Consensus on current management of endometriosis. Hum Reprod 2013; 28 (6): 1152–68.
18. Shimizu Y, Mita S, et al. Dienogest, a synthetic progestin, inhibits prostaglandin E2 production and aromatase expression by human endometrial epithelial cells in a spheroid culture system. Steroids 2011; 76: 60–7.
19. Strowitzki T, Marr J, Gerlinger C et al. Dienogest is as effective as leuprolide acetate in treating the painful symptoms of endometriosis: a 24-week, randomized, multicenter, opel-label trial. Hum Reprod 2010; 25 (3): 633–41.
2. Belaisch J, Allart JP. Endometriosis and surviving adolescence. Gynecol Obstet Fertil 2006; 34 (3): 242–7.
3. Frackiewicz EJ. Endometriosis: an overview of the disease and its treatment. J Am Pharm Assoc (Wash) 2000; 40 (5): 645–57.
4. Barbieri RL, Missmer S. Endometriosis and infertility: a cause-effect relationship? Ann N Y Acad Sci 2002; 95 (5): 23–33; discussion 34–6: 396–406.
5. Buletti С et al. J Assist Reprod Genet 2010; 27: 441–7.
6. Allaire C. Endometriosis and infertility: a review. J Reprod Med 2006; 51 (3): 164–8.
7. Garrido N, Navarro J, Garcia-Velasco J et al. The endometrium versus embryonic quality in endometriosis-related infertility. Hum Reprod Update 2002; 8 (1): 95–103.
8. De Ziegler D, Borghese B, Chapron C. Endometriosis and infertility: pathophysiology and management. Lancet 2010; 376: 730–8.
9. Khoufache K et al. Anomalies in the inflammatory response in endometriosis and possible consequences: a review. Minerva Endocrinol 2012; 37 (1): 75–92.
10. Баскаков В.П. Клиника и лечение эндометриоза. Л.: Медицина, 1990.
11. Matalliotakis IM, Athanassakis I, Goumenou AG et al. The possible anti-inflammatory role of circulating human leukocyte antigen levels in women with еndometriosis after treatment with danazol and leuprorelin acetate depot. Mediators Inflamm 2001; 10 (2): 75–80.
12. Brown J, Farqufar C. Endometriosis: an overview of Cochrane Reviews. Cochrane Database Syst Rev 2014; 10 (3): CD009590.
13. Oettel M, Carol W, Elger W et al. A 19-norprogestin without 17a-ethinyl group II: dienogest from a pharmacodynamic point of view. Drugs Today 1995; 31: 517–36.
14. McCormac Dienogest (review). Drugs 2010; 70 (16): 2073–88.
15. Nakamura et al. Eur J Pharmacol 1999; 386: 33–40.
16. Harada et al. Future science group, Women’s Health. 2010; 6 (1): 27–35.
17. Johnson NP, Hummelshoj L. Consensus on current management of endometriosis. Hum Reprod 2013; 28 (6): 1152–68.
18. Shimizu Y, Mita S, et al. Dienogest, a synthetic progestin, inhibits prostaglandin E2 production and aromatase expression by human endometrial epithelial cells in a spheroid culture system. Steroids 2011; 76: 60–7.
19. Strowitzki T, Marr J, Gerlinger C et al. Dienogest is as effective as leuprolide acetate in treating the painful symptoms of endometriosis: a 24-week, randomized, multicenter, opel-label trial. Hum Reprod 2010; 25 (3): 633–41.
________________________________________________
2. Belaisch J, Allart JP. Endometriosis and surviving adolescence. Gynecol Obstet Fertil 2006; 34 (3): 242–7.
3. Frackiewicz EJ. Endometriosis: an overview of the disease and its treatment. J Am Pharm Assoc (Wash) 2000; 40 (5): 645–57.
4. Barbieri RL, Missmer S. Endometriosis and infertility: a cause-effect relationship? Ann N Y Acad Sci 2002; 95 (5): 23–33; discussion 34–6: 396–406.
5. Buletti С et al. J Assist Reprod Genet 2010; 27: 441–7.
6. Allaire C. Endometriosis and infertility: a review. J Reprod Med 2006; 51 (3): 164–8.
7. Garrido N, Navarro J, Garcia-Velasco J et al. The endometrium versus embryonic quality in endometriosis-related infertility. Hum Reprod Update 2002; 8 (1): 95–103.
8. De Ziegler D, Borghese B, Chapron C. Endometriosis and infertility: pathophysiology and management. Lancet 2010; 376: 730–8.
9. Khoufache K et al. Anomalies in the inflammatory response in endometriosis and possible consequences: a review. Minerva Endocrinol 2012; 37 (1): 75–92.
10. Баскаков В.П. Клиника и лечение эндометриоза. Л.: Медицина, 1990.
11. Matalliotakis IM, Athanassakis I, Goumenou AG et al. The possible anti-inflammatory role of circulating human leukocyte antigen levels in women with еndometriosis after treatment with danazol and leuprorelin acetate depot. Mediators Inflamm 2001; 10 (2): 75–80.
12. Brown J, Farqufar C. Endometriosis: an overview of Cochrane Reviews. Cochrane Database Syst Rev 2014; 10 (3): CD009590.
13. Oettel M, Carol W, Elger W et al. A 19-norprogestin without 17a-ethinyl group II: dienogest from a pharmacodynamic point of view. Drugs Today 1995; 31: 517–36.
14. McCormac Dienogest (review). Drugs 2010; 70 (16): 2073–88.
15. Nakamura et al. Eur J Pharmacol 1999; 386: 33–40.
16. Harada et al. Future science group, Women’s Health. 2010; 6 (1): 27–35.
17. Johnson NP, Hummelshoj L. Consensus on current management of endometriosis. Hum Reprod 2013; 28 (6): 1152–68.
18. Shimizu Y, Mita S, et al. Dienogest, a synthetic progestin, inhibits prostaglandin E2 production and aromatase expression by human endometrial epithelial cells in a spheroid culture system. Steroids 2011; 76: 60–7.
19. Strowitzki T, Marr J, Gerlinger C et al. Dienogest is as effective as leuprolide acetate in treating the painful symptoms of endometriosis: a 24-week, randomized, multicenter, opel-label trial. Hum Reprod 2010; 25 (3): 633–41.
Авторы
А.М.Герасимов1, Л.В.Кулида2, Н.С.Брыкин3, Р.Н.Горта3
1. ФГБОУ ВПО Ивановская государственная медицинская академия Минздрава России;
2. ФГБУ Ивановский НИИ материнства и детства им. В.Н.Городкова Минздрава России;
3. ГБУЗ ВО Городская клиническая больница скорой медицинской помощи, Владимир
1. ФГБОУ ВПО Ивановская государственная медицинская академия Минздрава России;
2. ФГБУ Ивановский НИИ материнства и детства им. В.Н.Городкова Минздрава России;
3. ГБУЗ ВО Городская клиническая больница скорой медицинской помощи, Владимир
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