1. Косыгина А.В. Новое в патогенезе ожирения: адипокины – гормоны жировой ткани. Проблемы эндокринологии. 2009; 55 (1): 44–50.
2. Манухин И.Б., Геворкян М.А., Чагай Н.Б. Ановуляция и инсулино-резистентность. М., 2006.
3. Мельниченко Г.А., Романцова Т.И. Ожирение: эпидемиология, классификация, патогенез, клиническая симптоматика и диагностика. М.: МИА, 2004.
4. Angelidis G, Dafopoulos K, Messini CI et al. Ghrelin: new insights into female reproductive system-associated disorders and pregnancy. Reprod Sci 2012; 19 (9): 903–10.
5. Badman MK, Flier JS. The adipocyte as an active participant in energy balance and metabolism. Gastroenterology 2007; 132: 2103–15.
6. Beral VC. Ovarian cancer and body size: individual participant meta-analysis including 25,157 women with ovarian cancer from 47 epidemiological studies. PLoS Med 2012; 9: 100–20.
7. Bik W, Baranowska-Bik A, Wolinska-Witort E et al. The relationship between metabolic status and levels of adiponectin and ghrelin in lean women with polycystic ovary syndrome. Gynecol Endocrinol 2007; 23 (6): 325–31.
8. Blum CA, Muller B, Huber P et al. Low-grade inflammation and estimates of insulin resistance during the menstrual cycle in lean and overweight women. J Clin Endocrinol Metab 2009; 90: 3230–5.
9. Boeing H. Obesity and cancer – the update 2013. Best Pract Res Clin Endocrinol Metab 2013; 27: 219–27.
10. Bohler H, Mokshagundam S, Winters SJ. Adipose tissue and reproduction in women. Fertil Steril 2010; 94 (3): 795–825.
11. Brinkoetter M, Magkos F, Vamvini M et al. Leptin treatment reduces body fat but does not affect lean body mass or the myostatin-follistatin-activin axis in lean hypoleptinemic women. Am J Physiol Endocrinol Metab 2011; 301 (1): 99–104.
12. Budak E, Fernandez Sanchez M, Bellver J et al. Interactions of the hormones leptin, ghrelin, adiponectin, resistin, and PYY3-36 with the reproductive system. Fertil Steril 2006; 85: 1563–81.
13. Burnett MS, Devaney JM, Adenika RJ et al. Cross-sectional associations of resistin, coronary heart disease, and insulin resistance. J Clin Endocrinol Metab 2006; 91 (1): 64–8.
14. Campos DB, Palin MF, Bordignon V et al. The 'beneficial' adipokines in reproduction and fertility. Int J Obes (Lond) 2008; 32 (2): 223–31.
15. Cervero A, Horcajadas JA, Dominguez F et al. Leptin system inembryo development and implantation: a protein in search of a function. Reprod Biomed Online 2005; 10 (2): 217–23.
16. Chabrolle C, Tosca L, Rame C et al. Adiponectin increases insulin-like growth factor I-induced progesterone and estradiol secretion in human granulosa cells. Fertil Steril 2009; 92 (6): 1988–96.
17. Chavarro JE, Rich-Edwards JW, Rosner BA. A prospective study of dietary carbohydrate quantity and quality in relation to risk of ovulatory infertility. Eur J Clin Nutr 2009; 63 (1): 78–86.
18. Chavarro JE, Rich-Edwards JW, Rosner BA. Diet and lifestyle in the prevention of ovulatory disorder infertility. Obstetrics and gynecology 2007; 110 (5): 1050–8.
19. Chou SH, Mantzoros C. 20 years of leptin: role of leptin in human reproductive disorders. J Endocrinol 2014; 223 (1): 49–62.
20. Comninos AN, Jayasena CN, Dhillo WS. The relationship between gut and adipose hormones, and reproduction. Hum Reprod Update 2014; 20 (2): 153–74.
21. Craig JA, Zhu H, Dyce PW et al. Leptin enhances porcine preimplantation embryo development in vitro. Mol Cell Endocrinol 2005; 229 (1–2): 141–7.
22. Crujeiras AB, Casanueva FF. Obesity and the reproductive system disorders: epigenetics as a potential bridge. Hum Reprod Update 2014; 34 (5): 123–36.
23. De Pergola G, Tartagni M, d'Angelo F et al. Abdominal fat accumulation, and not insulin resistance, is associated to oligomenorrhea in non-hyperandrogenic overweight/obese women. J Endocrinol Invest 2009; 32 (2): 98–101.
24. Donato JrJ, Cravo RM, Frazao R et al. Hypothalamic sites of leptin action linking metabolism and reproduction. Neuroendocrinology 2011; 93 (1): 9–18.
25. Dos Santos E, Pecquery R, de Mazancourt P. Adiponectin and reproduction. Vitam Horm 2012; 90: 187–209.
26. Fain JN, Buehrer B, Bahouth SW et al. Comparison of messenger RNA distribution for 60 proteins in fat cells vs the nonfat cells of human omental adipose tissue. Metabolism 2008; 57: 1005–15.
27. Fietta P. Focus on leptin, a pleiotropic hormone. Minerva Med 2005; 96: 65–75.
28. Fischer-Posovszky P, Wabitsch M, Hochberg Z. Endocrinology of adipose tissue – an update. Horm Metab Res 2007; 39: 314–21.
29. Freeman EW, Gracia CR, Sammel MD et al. Association of anti-mulle­rian hormone levels with obesity in late reproductive-age women. Fertil Steril 2007; 87 (1): 101–6.
30. Galliano D, Bellver J. Female obesity: short- and long-term consequences on the offspring. Gynecol Endocrinol 2013; 29 (7): 626–31.
31. García MC, López M, Alvarez CV. Role of ghrelin in reproduction. Reproduction 2007; 133 (3): 531–40.
32. Guzik TJ, Mangalat D, Korbut R. Adipocytokines – novel link between inflammation and vascular function? J Physiol Pharmacol 2006; 57: 505–28.
33. Hausman GJ, Barb CR, Lents CA. Leptin and reproductive function. Biochimie 2012; 94 (10): 2075–81.
34. Heidemann C, Sun Q, van Dam RM et al. Total and highmolecular – weight adiponectin and resistin in relation to the risk for type 2 diabetes in women. Ann Intern Med 2008; 149 (5): 307–16.
35. Hirschberg AL. Polycystic ovary syndrome, obesity and reproductive implications. Womens Health (Lond Engl) 2009; 5 (5): 529–40.
36. Jungheim ES, Moley KH. The impact of type 1 and type 2 diabetes mellitus on the oocyte and the preimplantation embryo. Seminars in reproductive medicine 2008; 26 (2): 186–95.
37. Jungheim ES, Travieso JL, Carson KR. Obesity and reproductive function. Obstet Gynecol Clin North Am 2012; 39 (4): 479–93.
38. Jungheim ES, Travieso JL, Hopeman MM. Weighing the impact of obesity on female reproductive function and fertility. Nutr Rev 2013; 71: 3–8.
39. Kelesidis T, Mantzoros CS. The emerging role of leptin in humans. Pediatr Endocrinol Rev 2006; 3: 239–48.
40. Lorenzi T, Meli R, Marzioni D et al. Ghrelin: a metabolic signal affecting the reproductive system. Cytokine Growth Factor Rev 2009; 20: 137–52.
41. Mantzoros CS. Leptin in relation to the lipodystrophyassociated metabolic syndrome. Diabetes Metab J 2012; 36 (3): 181–9.
42. Mantzoros CS, Magkos F, Brinkoetter M et al. Leptin in human physiology and pathophysiology. Am J Physiol Endocrinol Metab 2011; 301 (4): 567–84.
43. Meier U, Gressner AM. Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin. Clin Chem 2004; 50 (9): 1511–25.
44. Metwally M, Li TC, Ledger WL. The impact of obesity on female reproductive function. Obes Rev 2007; 8 (6): 515–23.
45. Michalakis K, Mintziori G, Kaprara A. The complex interaction between obesity, metabolic syndrome and reproductive axis: a narrative review. Metabolism 2013; 62 (4): 457–78.
46. Mitchell M, Armstrong DT, Robker RL. Adipokines: implications for female fertility and obesity. Reproduction 2005; 130: 583–97.
47. Morash BA, Ur E, Wiesner G et al. Pituitary resistin gene expression: effects of age, gender and obesity. Neuroendocrinology 2004; 79 (3): 149–56.
48. Moreno-Aliaga MJ, Lorente-Cebrian S, Martinez JA. Regulation of adipokine secretion by n-3 fatty acids. Proc Nutr Soc 2010; 69 (3): 324–32.
49. Motta AB. The role of obesity in the development of polycystic ovary syndrome. Curr Pharm Des 2012; 18 (17): 2482–91.
50. Muccioli G, Lorenzi T, Lorenzi M. Beyond the metabolic role of ghrelin: a new player in the regulation of reproductive function. Peptides 2011; 32 (12): 2514–21.
51. O’Brien SM, Fitzgerald P, Scully P et al. Impact of gender and menstrual cycle phase on plasma cytokine concentrations. Neuroimmunomodulation 2007; 14: 84–90.
52. Obesity and reproduction: an educational bulletin. Fertil Steril 2008; 90 (Suppl. 5): 21–9.
53. Ogbuji QC. Obesity and reproductive performance in women. Afr J Reprod Health 2010; 14 (3): 143–51.
54. Ouchi N, Shibata R, Walsh K. Cardioprotection by adiponectin. Trends Cardiovasc Med 2006; 16 (5): 141–6.
55. Payette C, Blackburn P, Lamarche B et al. Sex differences in postprandial plasma tumor necrosis factor-alpha, interleukin-6, and C-reactive protein concentrations. Metabolism 2009; 58 (11): 1593–601.
56. Petzel M. Action of leptin on bone and its relationship to menopause. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2007; 151 (2): 195–9.
57. Pisto P, Ukkola O, Santaniemi M et al. Plasma adiponectin – an independent indicator of liver fat accumulation. Metabolism 2011; 60 (11): 1515–20.
58. Purcell SH, Moley KH. The impact of obesity on egg quality. J Assist Reprod Genet 2011; 28 (6): 517–24.
59. Rak-Mardyla A. Ghrelin role in hypothalamus-pituitary-ovarian axis. J Physiol Pharmacol 2013; 64 (6): 695–704.
60. Repaci A, Gambineri A, Pagotto U. Ghrelin and reproductive disorders. Mol Cell Endocrinol 2011; 340 (1): 70–9.
61. Roa J, Tena-Sempere M. Connecting metabolism and reproduction: Roles of central energy sensors and key molecular mediators. Mol Cell Endocrinol 2014; 45: 128–43.
62. Sanchez-Garrido MA, Tena-Sempere M. Metabolic control of puberty: roles of leptin and kisspeptins. Horm Behav 2013; 64: 187–94.
63. Santoro N, Lasley B, McConnell D et al. Body size and ethnicity are associated with menstrual cycle alterations in women in the early menopausal transition: the Study of Women's Health Across the Nation (SWAN) Daily Hormone Study. J Clin Endocrinol Metab 2004; 89 (6): 2622–31.
64. Savopoulos C, Michalakis K, Apostolopoulou M et al. Adipokines and stroke: a review of the literature. Maturitas 2011; 70 (4): 322–7.
65. Sirotkin AV, Pavlova S, Tena-Sempere M et al. Food restriction, ghrelin, its antagonist and obestatin control expression of ghrelin and its receptor in chicken hypothalamus and ovary. Comp Biochem Physiol A Mol Integr Physiol 2013; 164: 141–53.
66. Stengel A, Tache Y. Ghrelin – a pleiotropic hormone secreted from endocrine x/a-like cells of the stomach. Front Neurosci 2012; 6: 24.
67. Stofkova A. Resistin and visfatin: regulators of insulin sensitivity, inflammation and immunity. Endocr Regul 2010; 44 (1): 25–36.
68. Sturm R, An R. Obesity and economic environments. CA Cancer J Clin 2014; 64 (5): 337–50.
69. Szczepankiewicz D, Skrzypski M, Pruszynska-Oszmalek E et al. Importance of ghrelin in hypothalamus-pituitary axis on growth hormone release during normal pregnancy in the rat. J Physiol Pharmacol 2010; 61: 443–9.
70. Taylor PD, Samuelsson AM, Poston L. Maternal obesity and the developmental programming of hypertension: a role for leptin. Acta Physiol (Oxf) 2014; 210 (3): 508–23.
71. Tena-Sempere M. Ghrelin and reproduction: ghrelin as novel regulator of the gonadotropic axis. Vitam Horm 2008; 77: 285–300.
72. Tena-Sempere M. Ghrelin, the gonadal axis and the onset of puberty. Endocr Dev 2013; 25: 69–82.
73. Tomas E, Tsao TS, Saha AK et al. Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. Proc Natl Acad Sci USA 2002; 99 (25): 16309–13.
74. Toulis KA, Goulis DG, Farmakiotis D et al. Adiponectin levels in women with polycystic ovary syndrome: a systematic review and a meta-analysis. Hum Reprod Update 2009; 15 (3): 297–307.
75. Trujillo ME, Scherer PE. Adipose tissue–derived factors: impact on health and disease. Endocr Rev 2006; 27: 762–78.
76. Tzanavari T, Giannogonas P, Karalis KP. TNF-alpha and obesity. Curr Dir Autoimmun 2010; 11: 145–56.
77. Webb PM. Obesity and gynecologic cancer etiology and survival. Am Soc Clin Oncol Educ Book 2013; 33: 222–8.
78. Yamauchi J, Osawa H, Takasuka T et al. Serum resistin is reduced by glucose and meal loading in healthy human subjects. Metabolism 2008; 57 (2): 149–56.
79. Zhang J, Zhou L, Tang L et al. The plasma level and gene expression of resistin in polycystic ovary syndrome. Gynecol Endocrinol 2011; 27 (12): 982–7.

________________________________________________

1. Косыгина А.В. Новое в патогенезе ожирения: адипокины – гормоны жировой ткани. Проблемы эндокринологии. 2009; 55 (1): 44–50.
2. Манухин И.Б., Геворкян М.А., Чагай Н.Б. Ановуляция и инсулино-резистентность. М., 2006.
3. Мельниченко Г.А., Романцова Т.И. Ожирение: эпидемиология, классификация, патогенез, клиническая симптоматика и диагностика. М.: МИА, 2004.
4. Angelidis G, Dafopoulos K, Messini CI et al. Ghrelin: new insights into female reproductive system-associated disorders and pregnancy. Reprod Sci 2012; 19 (9): 903–10.
5. Badman MK, Flier JS. The adipocyte as an active participant in energy balance and metabolism. Gastroenterology 2007; 132: 2103–15.
6. Beral VC. Ovarian cancer and body size: individual participant meta-analysis including 25,157 women with ovarian cancer from 47 epidemiological studies. PLoS Med 2012; 9: 100–20.
7. Bik W, Baranowska-Bik A, Wolinska-Witort E et al. The relationship between metabolic status and levels of adiponectin and ghrelin in lean women with polycystic ovary syndrome. Gynecol Endocrinol 2007; 23 (6): 325–31.
8. Blum CA, Muller B, Huber P et al. Low-grade inflammation and estimates of insulin resistance during the menstrual cycle in lean and overweight women. J Clin Endocrinol Metab 2009; 90: 3230–5.
9. Boeing H. Obesity and cancer – the update 2013. Best Pract Res Clin Endocrinol Metab 2013; 27: 219–27.
10. Bohler H, Mokshagundam S, Winters SJ. Adipose tissue and reproduction in women. Fertil Steril 2010; 94 (3): 795–825.
11. Brinkoetter M, Magkos F, Vamvini M et al. Leptin treatment reduces body fat but does not affect lean body mass or the myostatin-follistatin-activin axis in lean hypoleptinemic women. Am J Physiol Endocrinol Metab 2011; 301 (1): 99–104.
12. Budak E, Fernandez Sanchez M, Bellver J et al. Interactions of the hormones leptin, ghrelin, adiponectin, resistin, and PYY3-36 with the reproductive system. Fertil Steril 2006; 85: 1563–81.
13. Burnett MS, Devaney JM, Adenika RJ et al. Cross-sectional associations of resistin, coronary heart disease, and insulin resistance. J Clin Endocrinol Metab 2006; 91 (1): 64–8.
14. Campos DB, Palin MF, Bordignon V et al. The 'beneficial' adipokines in reproduction and fertility. Int J Obes (Lond) 2008; 32 (2): 223–31.
15. Cervero A, Horcajadas JA, Dominguez F et al. Leptin system inembryo development and implantation: a protein in search of a function. Reprod Biomed Online 2005; 10 (2): 217–23.
16. Chabrolle C, Tosca L, Rame C et al. Adiponectin increases insulin-like growth factor I-induced progesterone and estradiol secretion in human granulosa cells. Fertil Steril 2009; 92 (6): 1988–96.
17. Chavarro JE, Rich-Edwards JW, Rosner BA. A prospective study of dietary carbohydrate quantity and quality in relation to risk of ovulatory infertility. Eur J Clin Nutr 2009; 63 (1): 78–86.
18. Chavarro JE, Rich-Edwards JW, Rosner BA. Diet and lifestyle in the prevention of ovulatory disorder infertility. Obstetrics and gynecology 2007; 110 (5): 1050–8.
19. Chou SH, Mantzoros C. 20 years of leptin: role of leptin in human reproductive disorders. J Endocrinol 2014; 223 (1): 49–62.
20. Comninos AN, Jayasena CN, Dhillo WS. The relationship between gut and adipose hormones, and reproduction. Hum Reprod Update 2014; 20 (2): 153–74.
21. Craig JA, Zhu H, Dyce PW et al. Leptin enhances porcine preimplantation embryo development in vitro. Mol Cell Endocrinol 2005; 229 (1–2): 141–7.
22. Crujeiras AB, Casanueva FF. Obesity and the reproductive system disorders: epigenetics as a potential bridge. Hum Reprod Update 2014; 34 (5): 123–36.
23. De Pergola G, Tartagni M, d'Angelo F et al. Abdominal fat accumulation, and not insulin resistance, is associated to oligomenorrhea in non-hyperandrogenic overweight/obese women. J Endocrinol Invest 2009; 32 (2): 98–101.
24. Donato JrJ, Cravo RM, Frazao R et al. Hypothalamic sites of leptin action linking metabolism and reproduction. Neuroendocrinology 2011; 93 (1): 9–18.
25. Dos Santos E, Pecquery R, de Mazancourt P. Adiponectin and reproduction. Vitam Horm 2012; 90: 187–209.
26. Fain JN, Buehrer B, Bahouth SW et al. Comparison of messenger RNA distribution for 60 proteins in fat cells vs the nonfat cells of human omental adipose tissue. Metabolism 2008; 57: 1005–15.
27. Fietta P. Focus on leptin, a pleiotropic hormone. Minerva Med 2005; 96: 65–75.
28. Fischer-Posovszky P, Wabitsch M, Hochberg Z. Endocrinology of adipose tissue – an update. Horm Metab Res 2007; 39: 314–21.
29. Freeman EW, Gracia CR, Sammel MD et al. Association of anti-mulle­rian hormone levels with obesity in late reproductive-age women. Fertil Steril 2007; 87 (1): 101–6.
30. Galliano D, Bellver J. Female obesity: short- and long-term consequences on the offspring. Gynecol Endocrinol 2013; 29 (7): 626–31.
31. García MC, López M, Alvarez CV. Role of ghrelin in reproduction. Reproduction 2007; 133 (3): 531–40.
32. Guzik TJ, Mangalat D, Korbut R. Adipocytokines – novel link between inflammation and vascular function? J Physiol Pharmacol 2006; 57: 505–28.
33. Hausman GJ, Barb CR, Lents CA. Leptin and reproductive function. Biochimie 2012; 94 (10): 2075–81.
34. Heidemann C, Sun Q, van Dam RM et al. Total and highmolecular – weight adiponectin and resistin in relation to the risk for type 2 diabetes in women. Ann Intern Med 2008; 149 (5): 307–16.
35. Hirschberg AL. Polycystic ovary syndrome, obesity and reproductive implications. Womens Health (Lond Engl) 2009; 5 (5): 529–40.
36. Jungheim ES, Moley KH. The impact of type 1 and type 2 diabetes mellitus on the oocyte and the preimplantation embryo. Seminars in reproductive medicine 2008; 26 (2): 186–95.
37. Jungheim ES, Travieso JL, Carson KR. Obesity and reproductive function. Obstet Gynecol Clin North Am 2012; 39 (4): 479–93.
38. Jungheim ES, Travieso JL, Hopeman MM. Weighing the impact of obesity on female reproductive function and fertility. Nutr Rev 2013; 71: 3–8.
39. Kelesidis T, Mantzoros CS. The emerging role of leptin in humans. Pediatr Endocrinol Rev 2006; 3: 239–48.
40. Lorenzi T, Meli R, Marzioni D et al. Ghrelin: a metabolic signal affecting the reproductive system. Cytokine Growth Factor Rev 2009; 20: 137–52.
41. Mantzoros CS. Leptin in relation to the lipodystrophyassociated metabolic syndrome. Diabetes Metab J 2012; 36 (3): 181–9.
42. Mantzoros CS, Magkos F, Brinkoetter M et al. Leptin in human physiology and pathophysiology. Am J Physiol Endocrinol Metab 2011; 301 (4): 567–84.
43. Meier U, Gressner AM. Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin. Clin Chem 2004; 50 (9): 1511–25.
44. Metwally M, Li TC, Ledger WL. The impact of obesity on female reproductive function. Obes Rev 2007; 8 (6): 515–23.
45. Michalakis K, Mintziori G, Kaprara A. The complex interaction between obesity, metabolic syndrome and reproductive axis: a narrative review. Metabolism 2013; 62 (4): 457–78.
46. Mitchell M, Armstrong DT, Robker RL. Adipokines: implications for female fertility and obesity. Reproduction 2005; 130: 583–97.
47. Morash BA, Ur E, Wiesner G et al. Pituitary resistin gene expression: effects of age, gender and obesity. Neuroendocrinology 2004; 79 (3): 149–56.
48. Moreno-Aliaga MJ, Lorente-Cebrian S, Martinez JA. Regulation of adipokine secretion by n-3 fatty acids. Proc Nutr Soc 2010; 69 (3): 324–32.
49. Motta AB. The role of obesity in the development of polycystic ovary syndrome. Curr Pharm Des 2012; 18 (17): 2482–91.
50. Muccioli G, Lorenzi T, Lorenzi M. Beyond the metabolic role of ghrelin: a new player in the regulation of reproductive function. Peptides 2011; 32 (12): 2514–21.
51. O’Brien SM, Fitzgerald P, Scully P et al. Impact of gender and menstrual cycle phase on plasma cytokine concentrations. Neuroimmunomodulation 2007; 14: 84–90.
52. Obesity and reproduction: an educational bulletin. Fertil Steril 2008; 90 (Suppl. 5): 21–9.
53. Ogbuji QC. Obesity and reproductive performance in women. Afr J Reprod Health 2010; 14 (3): 143–51.
54. Ouchi N, Shibata R, Walsh K. Cardioprotection by adiponectin. Trends Cardiovasc Med 2006; 16 (5): 141–6.
55. Payette C, Blackburn P, Lamarche B et al. Sex differences in postprandial plasma tumor necrosis factor-alpha, interleukin-6, and C-reactive protein concentrations. Metabolism 2009; 58 (11): 1593–601.
56. Petzel M. Action of leptin on bone and its relationship to menopause. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2007; 151 (2): 195–9.
57. Pisto P, Ukkola O, Santaniemi M et al. Plasma adiponectin – an independent indicator of liver fat accumulation. Metabolism 2011; 60 (11): 1515–20.
58. Purcell SH, Moley KH. The impact of obesity on egg quality. J Assist Reprod Genet 2011; 28 (6): 517–24.
59. Rak-Mardyla A. Ghrelin role in hypothalamus-pituitary-ovarian axis. J Physiol Pharmacol 2013; 64 (6): 695–704.
60. Repaci A, Gambineri A, Pagotto U. Ghrelin and reproductive disorders. Mol Cell Endocrinol 2011; 340 (1): 70–9.
61. Roa J, Tena-Sempere M. Connecting metabolism and reproduction: Roles of central energy sensors and key molecular mediators. Mol Cell Endocrinol 2014; 45: 128–43.
62. Sanchez-Garrido MA, Tena-Sempere M. Metabolic control of puberty: roles of leptin and kisspeptins. Horm Behav 2013; 64: 187–94.
63. Santoro N, Lasley B, McConnell D et al. Body size and ethnicity are associated with menstrual cycle alterations in women in the early menopausal transition: the Study of Women's Health Across the Nation (SWAN) Daily Hormone Study. J Clin Endocrinol Metab 2004; 89 (6): 2622–31.
64. Savopoulos C, Michalakis K, Apostolopoulou M et al. Adipokines and stroke: a review of the literature. Maturitas 2011; 70 (4): 322–7.
65. Sirotkin AV, Pavlova S, Tena-Sempere M et al. Food restriction, ghrelin, its antagonist and obestatin control expression of ghrelin and its receptor in chicken hypothalamus and ovary. Comp Biochem Physiol A Mol Integr Physiol 2013; 164: 141–53.
66. Stengel A, Tache Y. Ghrelin – a pleiotropic hormone secreted from endocrine x/a-like cells of the stomach. Front Neurosci 2012; 6: 24.
67. Stofkova A. Resistin and visfatin: regulators of insulin sensitivity, inflammation and immunity. Endocr Regul 2010; 44 (1): 25–36.
68. Sturm R, An R. Obesity and economic environments. CA Cancer J Clin 2014; 64 (5): 337–50.
69. Szczepankiewicz D, Skrzypski M, Pruszynska-Oszmalek E et al. Importance of ghrelin in hypothalamus-pituitary axis on growth hormone release during normal pregnancy in the rat. J Physiol Pharmacol 2010; 61: 443–9.
70. Taylor PD, Samuelsson AM, Poston L. Maternal obesity and the developmental programming of hypertension: a role for leptin. Acta Physiol (Oxf) 2014; 210 (3): 508–23.
71. Tena-Sempere M. Ghrelin and reproduction: ghrelin as novel regulator of the gonadotropic axis. Vitam Horm 2008; 77: 285–300.
72. Tena-Sempere M. Ghrelin, the gonadal axis and the onset of puberty. Endocr Dev 2013; 25: 69–82.
73. Tomas E, Tsao TS, Saha AK et al. Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. Proc Natl Acad Sci USA 2002; 99 (25): 16309–13.
74. Toulis KA, Goulis DG, Farmakiotis D et al. Adiponectin levels in women with polycystic ovary syndrome: a systematic review and a meta-analysis. Hum Reprod Update 2009; 15 (3): 297–307.
75. Trujillo ME, Scherer PE. Adipose tissue–derived factors: impact on health and disease. Endocr Rev 2006; 27: 762–78.
76. Tzanavari T, Giannogonas P, Karalis KP. TNF-alpha and obesity. Curr Dir Autoimmun 2010; 11: 145–56.
77. Webb PM. Obesity and gynecologic cancer etiology and survival. Am Soc Clin Oncol Educ Book 2013; 33: 222–8.
78. Yamauchi J, Osawa H, Takasuka T et al. Serum resistin is reduced by glucose and meal loading in healthy human subjects. Metabolism 2008; 57 (2): 149–56.
79. Zhang J, Zhou L, Tang L et al. The plasma level and gene expression of resistin in polycystic ovary syndrome. Gynecol Endocrinol 2011; 27 (12): 982–7.

И.В.Кузнецова, Э.Р.Ведзижева, Ю.Б.Успенская, И.В.Васильева

ГБОУ ВПО Первый Московский государственный медицинский университет им. И.М.Сеченова Минздрава России

________________________________________________

I.V.Kuznetsova, E.R.Vedzizheva, Yu.B.Uspenskaya, I.V.Vasilyeva