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Значение витаминно-минеральных комплексов в обеспечении нормального течения беременности и развития плода
Значение витаминно-минеральных комплексов в обеспечении нормального течения беременности и развития плода
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Аннотация
Витамины и минералы абсолютно необходимы для обеспечения нормального зачатия, беременности, развития плода и ребенка, и широкое распространение микронутриентной недостаточности в современной популяции неблагоприятно отражается на состоянии здоровья матерей и детей. Дотация витаминов и минералов на этапе прегравидарной подготовки и во время беременности служит важным фактором профилактики самопроизвольного выкидыша, преждевременных родов, нарушений функции фетоплацентарного комплекса, пороков развития плода и рождения незрелых или маловесных детей, причем оптимальным способом введения необходимых микронутриентов признается использование витаминно-минеральных комплексов. Витаминно-минеральные комплексы имеют очевидные преимущества по сравнению с дотацией отдельных микронутриентов у беременных женщин. В обзоре освещается роль витаминов и минералов в успешном течении беременности и обосновывается их профилактическое применение.
Ключевые слова: беременность, витамины, минералы, микронутриентный дефицит, осложнения беременности, пороки развития новорожденных.
Key words: pregnancy, vitamins, minerals, micronutrient deficiency, pregnancy complications, neonatal malformations.
Ключевые слова: беременность, витамины, минералы, микронутриентный дефицит, осложнения беременности, пороки развития новорожденных.
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Key words: pregnancy, vitamins, minerals, micronutrient deficiency, pregnancy complications, neonatal malformations.
Полный текст
Список литературы
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31. Chan J, Deng L, Mikael LG. Low dietary choline and low dietary riboflavin during pregnancy influence reproductive outcomes and heart development in mice. Am J Clin Nutr 2010; 91 (4): 1035–43.
32. Robitaille J, Carmichael SL, Shaw GM, Olney RS. Maternal nutrient intake and risks for transverse and longitudinal limb deficiencies: data from the National Birth Defects Prevention Study, 1997–2003. Birth Defects Res A Clin Mol Teratol 2009; 85 (9): 773–9.
33. Wallenstein MB, Shaw GM, Yang W, Carmichael SL. Periconceptional nutrient intakes and risks of orofacial clefts in California. Pediatr Res 2013; 74 (4): 457–65.
34. Shaw GM, Carmichael SL, Yang W, Lammer EJ. Periconceptional nutrient intakes and risks of conotruncal heart defects. Birth Defects Res A Clin Mol Teratol 2010; 88 (3): 144–51.
35. Nakajima Y1, Imanaka-Yoshida K. New insights into the developmental mechanisms of coronary vessels and epicardium. Int Rev Cell Mol Biol 2013; 303: 263–317.
36. Hill B, Holroyd R, Sullivan M. Clinical and pathological findings associated with congenital hypovitaminosis A in extensively grazed beef cattle. Aust Vet J 2009; 87 (3): 94–8.
37. Clagett-Dame M, Knutson D. Vitamin A in Reproduction and Development. Nutrients 2011; 3 (4): 385–428.
38. Beurskens LW, Tibboel D, Retinol status of newborn infants is associated with congenital diaphragmatic hernia. Pediatrics 2010; 126 (4): 712–20.
39. Chen K, Zhang X, Wei XP. Antioxidant vitamin status during pregnancy in relation to cognitive development in the first two years of life. Early Hum Dev 2009; 85 (7): 421–7.
40. Askin DF, Diehl-Jones W. Pathogenesis and prevention of chronic lung disease in the neonate. Crit Care Nurs Clin North Am 2009; 21 (1): 11–25.
41. Thorne-Lyman AL, Fawzi WW. Vitamin A and carotenoids during pregnancy and maternal, neonatal and infant health outcomes: A systematic review and meta-analysis. Paediatr Perinat Epidemiol 2012; 26 (1): 10.1111/j.1365-3016.2012.01284.x.
42. Dheen ST, Tay SS. Recent studies on neural tube defects in embryos of diabetic pregnancy: an overview. Curr Med Chem 2009; 16 (18): 2345–54.
43. Carmichael SL, Rasmussen SA, Lammer EJ et al. Craniosynostosis and nutrient intake during pregnancy. Birth Defects Res A Clin Mol Teratol 2010; 88 (12): 1032–9.
44. Mulligan ML, Felton SK, Riek AE, Bernal-Mizrachi C. Implications of vitamin D deficiency in pregnancy and lactation. Am J Obstet Gynecol 2009; 202 (5): 429.
45. Houben ML, Bont L, Wilbrink B et al. Clinical prediction rule for RSV bronchiolitis in healthy newborns: Prognostic birth cohort study. Pediatrics 2011; 127: 35–41.
46. Hollis BW, Johnson D, Hulsey TC et al. Vitamin D supplementation during pregnancy: Double-blind, randomized clinical trial of safety and effectiveness. J Bone Miner Res 2011; 26: 2341–57.
47. Agarwal A, Gupta S, Sharma RK. Role of oxidative stress in female reproduction. Reprod Biol Endocrinol 2005; 3: 28.
48. Hara K, Akiyama Y. Collagen-related abnormalities, reduction in bone quality, and effects of menatetrenone in rats with a congenital ascorbic acid deficiency. J Bone Miner Metab 2009; 27 (3): 324–32.
49. Формулярная система. Федеральное руководство. М.: ГЭОТАР-Мед, 2010.
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51. Kasimanickam RK, Kasimanickam VR, Rodriguez JS et al. Tocopherol induced angiogenesis in placental vascular network in late pregnant ewes. Reprod Biol Endocrinol 2010; 8: 86.
52. Klemmensen A, Tabor A, Osterdal ML. Intake of vitamin C and E in pregnancy and risk of pre-eclampsia: prospective study among 57346 women. BJOG 2009; 116 (7): 964–74.
53. Saffery R, Ellis J, Morley R. A convergent model for placental dysfunction encompassing combined sub-optimal one-carbon donor and vitamin D bioavailability. Med Hypotheses 2009; 73 (6): 1023–8.
54. Wagner CL, Taylor SN, Dawodu A et al. Vitamin D and Its Role During Pregnancy in Attaining Optimal Health of Mother and Fetus. Nutrients 2012; 4 (3): 208–230.
55. James MF. Magnesium in obstetrics. Best Pract Res Clin Obstet Gynec 2010; 24 (3): 327–37.
56. Стуров Н.В. Некоторые аспекты применения пероральных препаратов магния. Трудный пациент. 2012; 7: 28–31.
57. Недогода С.В. Роль препаратов магния в ведении пациентов терапевтического профиля. Лечащий врач. 2009; 6: 16–9.
58. Буданова М.В., Асланова П.А., Буданов П.В. Клинические проявления и эффекты коррекции дефицита магния у детей. Трудный пациент. 2009; 1–2: 17–22.
59. Шмаков Р.Г. Применение магния в акушерстве. Лечащий врач. 2010; 11: 15–20.
2. Генетический паспорт – основа индивидуальной и предиктивной медицины. Под ред. В.С.Баранова. СПб.: Изд-во Н-Л, 2009.
3. Yi Y, Lindemann M, Colligs A, Snowball C. Economic burden of NTDs. Eur J Pediatr 2011; 170: 1391–400.
4. Guillette JrLJ, Moore BC. Environmental contaminants, fertility, and multioocytic follicles: a lesson from wildlife? Semin Reprod Med 2006; 24 (3): 134–41.
5. Torshin IY, Gromova OA. Magnesium and pyridoxine: fundamental studies and clinical practice. Nova Science 2009.
6. Маталыгина О.А. Питание беременных и кормящих женщин. Решенные и нерешенные проблемы. Вопр. соврем. педиатрии. 2008; 7 (5): 23–9.
7. Хорошилов И.Е., Успенский Ю.В. Новые подходы в лечебном питании беременных и кормящих женщин. Гинекология. 2008; 4: 67–77.
8. Lennard L. Methyltransferases. In: Guengerich FP (ed) Bio-transformation. Comprehensive toxicology, 2010; 4 (Chap 21). Elsevier, Oxford, UK.
9. Wu X, Zou T, Cao N et al. Plasma homocysteine levels and genetic polymorphisms in folate metablism are associated with breast cancer risk in chinese women. Hered Cancer Clin Pract 2014; 12 (1): 2.
10. Berenson AB, Rahman M. Effect of hormonal contraceptives on vitamin B12 leveland the association of the latter with bonemineraldensity. Contraception 2012; 86 (5): 481–7.
11. Monteiro JP, Wise C, Morine MJ et al. Methylation potential associated with diet, genotype, protein, and metabolite levels in the Delta Obesity Vitamin Study. Genes Nutr 2014; 9: 403–22.
12. Baumgartner MR. Vitamin-responsive disorders: cobalamin, folate, biotin, vitamins B1 and E. Handb Clin Neurol 2013; 113: 1799–10.
13. Abe I, Shirato Y, Hashizume Y et al. Folate-deficiency induced cell-specific changes in the distribution of lymphocytes and granulocytes in rats. Environ Health Prev Med 2013; 18: 78–84.
14. Mujawar SA, Patil VW, Daver RG. Study of serum homocysteine, folic acid and vitamin B12 in patients with preeclampsia. Indian J Clin Biochem 2011; 26 (3): 257–60.
15. Rodriguez-Guillen MR, Torres-Sánchez L, Chen J et al. Hernández-Valero, Lizbeth López-Carrillo. Dietary consumption of B vitamins, maternal MTHFR polymorphisms and risk for spontaneous abortion. Salud Publica Mex 2009; 51 (1): 19–25.
16. Schmidt RJ, Tancredi DJ, Ozonoff S et al. Maternal periconceptionalfolic acid intake and risk of autism spectrum disorders and developmental delay in the CHARGE (CHildhoodAutism Risks from Genetics and Environment) case-control study. Am J Clin Nutr 2012; 96 (1): 80–9.
17. Orjuela MA, Cabrera-Muñoz L, Paul L et al. Risk of retinoblastoma is associated with a maternal polymorphism in dihydrofolatereductase (DHFR) and prenatal folic acid intake. Cancer 2012; 118 (23): 5912–19.
18. De-Regil LM, Fernández-Gaxiola AC, Dowswell T, Peña-Rosas JP. Effects and safety of periconceptionalfolate supplementation for preventing birth defects. Cochrane Database Syst Rev 2010; 10: CD007950.
19. Imbard A, Benoist J-F, Blom HJ. Neural Tube Defects, Folic Acid and Methylation. Int J Environ Res Public Health 2013; 10 (9): 4352–89.
20. Mosley BS, Cleves MA, Siega-Riz AM et al. Neural tube defects and maternal folate intake among pregnancies conceived after folic acid fortification in the United States. Am J Epidemiol 2009; 169: 9–17.
21. Oyama K. Folic acid prevents congenital malformations in the offspring of diabetic mice. Endocr J 2009; 56 (1): 29–37.
22. Громова О.А., Торшин И.Ю., Тетруашвили Н.К., Сидельникова В.М. Нутрициальный подход к профилактике избыточной массы тела новорожденных. Гинекология. 2010; 12 (5): 56–61.
23. Krawinkel MB, Strohm D, Weissenborn A et al. Revised D-A-CH intake recommendations for folate: how much is needed? Eur J Clin Nutr 2014; 68 (6): 719–23.
24. Громова О.А., Торшин И.Ю. Применение фолиевой кислоты в акушерстве и гинекологии. М.: РСЦ ЮНЕСКО, 2009.
25. Bailey SW, Ayling JE. Rapid folate repletion: an adjunct approach for reduction of risk for neural tube and other birth defects. Abstr 18th World Congr Controvers Obstet Gynecol Infert 2013; 90.
26. Brämswig S, Prinz-Langenohl R, Lamers Y et al. Supplementation with a multivitamin containing 800 microg of folic acid shortens the time to reach the preventive red blood cell folate concentration in healthy women. Int J Vitam Nutr Res 2009; 79 (2): 61–70.
27. Yoshino K, Nishide M, Sankai T et al. Validity of brief food frequency questionnaire for estimation of dietary intakes of folate, vitamins B6 and B12, and their associations with plasma homocysteine concentrations. Int J Food Sci Nutr 2010; 61 (1): 61–7.
28. Scaglione F, Panzavolta G. Folate, folicacidand 5-methyltetrahydrofolate are notthesamething. Xenobiotica 2014; 44 (5): 480–8.
29. Molloy AM, Kirke PN, Troendle JF. Maternal vitamin B12 status and risk of neural tube defects in a population with high neural tube defect prevalence and no folic Acid fortification. Pediatrics 2009; 123 (3): 917–23.
30. Zhang T, Xin R, Gu X, Wang F. Maternal serum vitamin B12, folate and homocysteine and the risk of neural tube defects in the offspring in a high-risk area of China. Public Health Nutr 2009; 12 (5): 68086.
31. Chan J, Deng L, Mikael LG. Low dietary choline and low dietary riboflavin during pregnancy influence reproductive outcomes and heart development in mice. Am J Clin Nutr 2010; 91 (4): 1035–43.
32. Robitaille J, Carmichael SL, Shaw GM, Olney RS. Maternal nutrient intake and risks for transverse and longitudinal limb deficiencies: data from the National Birth Defects Prevention Study, 1997–2003. Birth Defects Res A Clin Mol Teratol 2009; 85 (9): 773–9.
33. Wallenstein MB, Shaw GM, Yang W, Carmichael SL. Periconceptional nutrient intakes and risks of orofacial clefts in California. Pediatr Res 2013; 74 (4): 457–65.
34. Shaw GM, Carmichael SL, Yang W, Lammer EJ. Periconceptional nutrient intakes and risks of conotruncal heart defects. Birth Defects Res A Clin Mol Teratol 2010; 88 (3): 144–51.
35. Nakajima Y1, Imanaka-Yoshida K. New insights into the developmental mechanisms of coronary vessels and epicardium. Int Rev Cell Mol Biol 2013; 303: 263–317.
36. Hill B, Holroyd R, Sullivan M. Clinical and pathological findings associated with congenital hypovitaminosis A in extensively grazed beef cattle. Aust Vet J 2009; 87 (3): 94–8.
37. Clagett-Dame M, Knutson D. Vitamin A in Reproduction and Development. Nutrients 2011; 3 (4): 385–428.
38. Beurskens LW, Tibboel D, Retinol status of newborn infants is associated with congenital diaphragmatic hernia. Pediatrics 2010; 126 (4): 712–20.
39. Chen K, Zhang X, Wei XP. Antioxidant vitamin status during pregnancy in relation to cognitive development in the first two years of life. Early Hum Dev 2009; 85 (7): 421–7.
40. Askin DF, Diehl-Jones W. Pathogenesis and prevention of chronic lung disease in the neonate. Crit Care Nurs Clin North Am 2009; 21 (1): 11–25.
41. Thorne-Lyman AL, Fawzi WW. Vitamin A and carotenoids during pregnancy and maternal, neonatal and infant health outcomes: A systematic review and meta-analysis. Paediatr Perinat Epidemiol 2012; 26 (1): 10.1111/j.1365-3016.2012.01284.x.
42. Dheen ST, Tay SS. Recent studies on neural tube defects in embryos of diabetic pregnancy: an overview. Curr Med Chem 2009; 16 (18): 2345–54.
43. Carmichael SL, Rasmussen SA, Lammer EJ et al. Craniosynostosis and nutrient intake during pregnancy. Birth Defects Res A Clin Mol Teratol 2010; 88 (12): 1032–9.
44. Mulligan ML, Felton SK, Riek AE, Bernal-Mizrachi C. Implications of vitamin D deficiency in pregnancy and lactation. Am J Obstet Gynecol 2009; 202 (5): 429.
45. Houben ML, Bont L, Wilbrink B et al. Clinical prediction rule for RSV bronchiolitis in healthy newborns: Prognostic birth cohort study. Pediatrics 2011; 127: 35–41.
46. Hollis BW, Johnson D, Hulsey TC et al. Vitamin D supplementation during pregnancy: Double-blind, randomized clinical trial of safety and effectiveness. J Bone Miner Res 2011; 26: 2341–57.
47. Agarwal A, Gupta S, Sharma RK. Role of oxidative stress in female reproduction. Reprod Biol Endocrinol 2005; 3: 28.
48. Hara K, Akiyama Y. Collagen-related abnormalities, reduction in bone quality, and effects of menatetrenone in rats with a congenital ascorbic acid deficiency. J Bone Miner Metab 2009; 27 (3): 324–32.
49. Формулярная система. Федеральное руководство. М.: ГЭОТАР-Мед, 2010.
50. Munoz C, Carson AF, McCoy MA et al. Effect of supplementation with barium selenate on the fertility, prolificacy and lambing performance of hill sheep. Vet Rec 2009; 164 (9): 265–71.
51. Kasimanickam RK, Kasimanickam VR, Rodriguez JS et al. Tocopherol induced angiogenesis in placental vascular network in late pregnant ewes. Reprod Biol Endocrinol 2010; 8: 86.
52. Klemmensen A, Tabor A, Osterdal ML. Intake of vitamin C and E in pregnancy and risk of pre-eclampsia: prospective study among 57346 women. BJOG 2009; 116 (7): 964–74.
53. Saffery R, Ellis J, Morley R. A convergent model for placental dysfunction encompassing combined sub-optimal one-carbon donor and vitamin D bioavailability. Med Hypotheses 2009; 73 (6): 1023–8.
54. Wagner CL, Taylor SN, Dawodu A et al. Vitamin D and Its Role During Pregnancy in Attaining Optimal Health of Mother and Fetus. Nutrients 2012; 4 (3): 208–230.
55. James MF. Magnesium in obstetrics. Best Pract Res Clin Obstet Gynec 2010; 24 (3): 327–37.
56. Стуров Н.В. Некоторые аспекты применения пероральных препаратов магния. Трудный пациент. 2012; 7: 28–31.
57. Недогода С.В. Роль препаратов магния в ведении пациентов терапевтического профиля. Лечащий врач. 2009; 6: 16–9.
58. Буданова М.В., Асланова П.А., Буданов П.В. Клинические проявления и эффекты коррекции дефицита магния у детей. Трудный пациент. 2009; 1–2: 17–22.
59. Шмаков Р.Г. Применение магния в акушерстве. Лечащий врач. 2010; 11: 15–20.
2. Генетический паспорт – основа индивидуальной и предиктивной медицины. Под ред. В.С.Баранова. СПб.: Изд-во Н-Л, 2009.
3. Yi Y, Lindemann M, Colligs A, Snowball C. Economic burden of NTDs. Eur J Pediatr 2011; 170: 1391–400.
4. Guillette JrLJ, Moore BC. Environmental contaminants, fertility, and multioocytic follicles: a lesson from wildlife? Semin Reprod Med 2006; 24 (3): 134–41.
5. Torshin IY, Gromova OA. Magnesium and pyridoxine: fundamental studies and clinical practice. Nova Science 2009.
6. Маталыгина О.А. Питание беременных и кормящих женщин. Решенные и нерешенные проблемы. Вопр. соврем. педиатрии. 2008; 7 (5): 23–9.
7. Хорошилов И.Е., Успенский Ю.В. Новые подходы в лечебном питании беременных и кормящих женщин. Гинекология. 2008; 4: 67–77.
8. Lennard L. Methyltransferases. In: Guengerich FP (ed) Bio-transformation. Comprehensive toxicology, 2010; 4 (Chap 21). Elsevier, Oxford, UK.
9. Wu X, Zou T, Cao N et al. Plasma homocysteine levels and genetic polymorphisms in folate metablism are associated with breast cancer risk in chinese women. Hered Cancer Clin Pract 2014; 12 (1): 2.
10. Berenson AB, Rahman M. Effect of hormonal contraceptives on vitamin B12 leveland the association of the latter with bonemineraldensity. Contraception 2012; 86 (5): 481–7.
11. Monteiro JP, Wise C, Morine MJ et al. Methylation potential associated with diet, genotype, protein, and metabolite levels in the Delta Obesity Vitamin Study. Genes Nutr 2014; 9: 403–22.
12. Baumgartner MR. Vitamin-responsive disorders: cobalamin, folate, biotin, vitamins B1 and E. Handb Clin Neurol 2013; 113: 1799–10.
13. Abe I, Shirato Y, Hashizume Y et al. Folate-deficiency induced cell-specific changes in the distribution of lymphocytes and granulocytes in rats. Environ Health Prev Med 2013; 18: 78–84.
14. Mujawar SA, Patil VW, Daver RG. Study of serum homocysteine, folic acid and vitamin B12 in patients with preeclampsia. Indian J Clin Biochem 2011; 26 (3): 257–60.
15. Rodriguez-Guillen MR, Torres-Sánchez L, Chen J et al. Hernández-Valero, Lizbeth López-Carrillo. Dietary consumption of B vitamins, maternal MTHFR polymorphisms and risk for spontaneous abortion. Salud Publica Mex 2009; 51 (1): 19–25.
16. Schmidt RJ, Tancredi DJ, Ozonoff S et al. Maternal periconceptionalfolic acid intake and risk of autism spectrum disorders and developmental delay in the CHARGE (CHildhoodAutism Risks from Genetics and Environment) case-control study. Am J Clin Nutr 2012; 96 (1): 80–9.
17. Orjuela MA, Cabrera-Muñoz L, Paul L et al. Risk of retinoblastoma is associated with a maternal polymorphism in dihydrofolatereductase (DHFR) and prenatal folic acid intake. Cancer 2012; 118 (23): 5912–19.
18. De-Regil LM, Fernández-Gaxiola AC, Dowswell T, Peña-Rosas JP. Effects and safety of periconceptionalfolate supplementation for preventing birth defects. Cochrane Database Syst Rev 2010; 10: CD007950.
19. Imbard A, Benoist J-F, Blom HJ. Neural Tube Defects, Folic Acid and Methylation. Int J Environ Res Public Health 2013; 10 (9): 4352–89.
20. Mosley BS, Cleves MA, Siega-Riz AM et al. Neural tube defects and maternal folate intake among pregnancies conceived after folic acid fortification in the United States. Am J Epidemiol 2009; 169: 9–17.
21. Oyama K. Folic acid prevents congenital malformations in the offspring of diabetic mice. Endocr J 2009; 56 (1): 29–37.
22. Громова О.А., Торшин И.Ю., Тетруашвили Н.К., Сидельникова В.М. Нутрициальный подход к профилактике избыточной массы тела новорожденных. Гинекология. 2010; 12 (5): 56–61.
23. Krawinkel MB, Strohm D, Weissenborn A et al. Revised D-A-CH intake recommendations for folate: how much is needed? Eur J Clin Nutr 2014; 68 (6): 719–23.
24. Громова О.А., Торшин И.Ю. Применение фолиевой кислоты в акушерстве и гинекологии. М.: РСЦ ЮНЕСКО, 2009.
25. Bailey SW, Ayling JE. Rapid folate repletion: an adjunct approach for reduction of risk for neural tube and other birth defects. Abstr 18th World Congr Controvers Obstet Gynecol Infert 2013; 90.
26. Brämswig S, Prinz-Langenohl R, Lamers Y et al. Supplementation with a multivitamin containing 800 microg of folic acid shortens the time to reach the preventive red blood cell folate concentration in healthy women. Int J Vitam Nutr Res 2009; 79 (2): 61–70.
27. Yoshino K, Nishide M, Sankai T et al. Validity of brief food frequency questionnaire for estimation of dietary intakes of folate, vitamins B6 and B12, and their associations with plasma homocysteine concentrations. Int J Food Sci Nutr 2010; 61 (1): 61–7.
28. Scaglione F, Panzavolta G. Folate, folicacidand 5-methyltetrahydrofolate are notthesamething. Xenobiotica 2014; 44 (5): 480–8.
29. Molloy AM, Kirke PN, Troendle JF. Maternal vitamin B12 status and risk of neural tube defects in a population with high neural tube defect prevalence and no folic Acid fortification. Pediatrics 2009; 123 (3): 917–23.
30. Zhang T, Xin R, Gu X, Wang F. Maternal serum vitamin B12, folate and homocysteine and the risk of neural tube defects in the offspring in a high-risk area of China. Public Health Nutr 2009; 12 (5): 68086.
31. Chan J, Deng L, Mikael LG. Low dietary choline and low dietary riboflavin during pregnancy influence reproductive outcomes and heart development in mice. Am J Clin Nutr 2010; 91 (4): 1035–43.
32. Robitaille J, Carmichael SL, Shaw GM, Olney RS. Maternal nutrient intake and risks for transverse and longitudinal limb deficiencies: data from the National Birth Defects Prevention Study, 1997–2003. Birth Defects Res A Clin Mol Teratol 2009; 85 (9): 773–9.
33. Wallenstein MB, Shaw GM, Yang W, Carmichael SL. Periconceptional nutrient intakes and risks of orofacial clefts in California. Pediatr Res 2013; 74 (4): 457–65.
34. Shaw GM, Carmichael SL, Yang W, Lammer EJ. Periconceptional nutrient intakes and risks of conotruncal heart defects. Birth Defects Res A Clin Mol Teratol 2010; 88 (3): 144–51.
35. Nakajima Y1, Imanaka-Yoshida K. New insights into the developmental mechanisms of coronary vessels and epicardium. Int Rev Cell Mol Biol 2013; 303: 263–317.
36. Hill B, Holroyd R, Sullivan M. Clinical and pathological findings associated with congenital hypovitaminosis A in extensively grazed beef cattle. Aust Vet J 2009; 87 (3): 94–8.
37. Clagett-Dame M, Knutson D. Vitamin A in Reproduction and Development. Nutrients 2011; 3 (4): 385–428.
38. Beurskens LW, Tibboel D, Retinol status of newborn infants is associated with congenital diaphragmatic hernia. Pediatrics 2010; 126 (4): 712–20.
39. Chen K, Zhang X, Wei XP. Antioxidant vitamin status during pregnancy in relation to cognitive development in the first two years of life. Early Hum Dev 2009; 85 (7): 421–7.
40. Askin DF, Diehl-Jones W. Pathogenesis and prevention of chronic lung disease in the neonate. Crit Care Nurs Clin North Am 2009; 21 (1): 11–25.
41. Thorne-Lyman AL, Fawzi WW. Vitamin A and carotenoids during pregnancy and maternal, neonatal and infant health outcomes: A systematic review and meta-analysis. Paediatr Perinat Epidemiol 2012; 26 (1): 10.1111/j.1365-3016.2012.01284.x.
42. Dheen ST, Tay SS. Recent studies on neural tube defects in embryos of diabetic pregnancy: an overview. Curr Med Chem 2009; 16 (18): 2345–54.
43. Carmichael SL, Rasmussen SA, Lammer EJ et al. Craniosynostosis and nutrient intake during pregnancy. Birth Defects Res A Clin Mol Teratol 2010; 88 (12): 1032–9.
44. Mulligan ML, Felton SK, Riek AE, Bernal-Mizrachi C. Implications of vitamin D deficiency in pregnancy and lactation. Am J Obstet Gynecol 2009; 202 (5): 429.
45. Houben ML, Bont L, Wilbrink B et al. Clinical prediction rule for RSV bronchiolitis in healthy newborns: Prognostic birth cohort study. Pediatrics 2011; 127: 35–41.
46. Hollis BW, Johnson D, Hulsey TC et al. Vitamin D supplementation during pregnancy: Double-blind, randomized clinical trial of safety and effectiveness. J Bone Miner Res 2011; 26: 2341–57.
47. Agarwal A, Gupta S, Sharma RK. Role of oxidative stress in female reproduction. Reprod Biol Endocrinol 2005; 3: 28.
48. Hara K, Akiyama Y. Collagen-related abnormalities, reduction in bone quality, and effects of menatetrenone in rats with a congenital ascorbic acid deficiency. J Bone Miner Metab 2009; 27 (3): 324–32.
49. Формулярная система. Федеральное руководство. М.: ГЭОТАР-Мед, 2010.
50. Munoz C, Carson AF, McCoy MA et al. Effect of supplementation with barium selenate on the fertility, prolificacy and lambing performance of hill sheep. Vet Rec 2009; 164 (9): 265–71.
51. Kasimanickam RK, Kasimanickam VR, Rodriguez JS et al. Tocopherol induced angiogenesis in placental vascular network in late pregnant ewes. Reprod Biol Endocrinol 2010; 8: 86.
52. Klemmensen A, Tabor A, Osterdal ML. Intake of vitamin C and E in pregnancy and risk of pre-eclampsia: prospective study among 57346 women. BJOG 2009; 116 (7): 964–74.
53. Saffery R, Ellis J, Morley R. A convergent model for placental dysfunction encompassing combined sub-optimal one-carbon donor and vitamin D bioavailability. Med Hypotheses 2009; 73 (6): 1023–8.
54. Wagner CL, Taylor SN, Dawodu A et al. Vitamin D and Its Role During Pregnancy in Attaining Optimal Health of Mother and Fetus. Nutrients 2012; 4 (3): 208–230.
55. James MF. Magnesium in obstetrics. Best Pract Res Clin Obstet Gynec 2010; 24 (3): 327–37.
56. Стуров Н.В. Некоторые аспекты применения пероральных препаратов магния. Трудный пациент. 2012; 7: 28–31.
57. Недогода С.В. Роль препаратов магния в ведении пациентов терапевтического профиля. Лечащий врач. 2009; 6: 16–9.
58. Буданова М.В., Асланова П.А., Буданов П.В. Клинические проявления и эффекты коррекции дефицита магния у детей. Трудный пациент. 2009; 1–2: 17–22.
59. Шмаков Р.Г. Применение магния в акушерстве. Лечащий врач. 2010; 11: 15–20.
________________________________________________
2. Генетический паспорт – основа индивидуальной и предиктивной медицины. Под ред. В.С.Баранова. СПб.: Изд-во Н-Л, 2009.
3. Yi Y, Lindemann M, Colligs A, Snowball C. Economic burden of NTDs. Eur J Pediatr 2011; 170: 1391–400.
4. Guillette JrLJ, Moore BC. Environmental contaminants, fertility, and multioocytic follicles: a lesson from wildlife? Semin Reprod Med 2006; 24 (3): 134–41.
5. Torshin IY, Gromova OA. Magnesium and pyridoxine: fundamental studies and clinical practice. Nova Science 2009.
6. Маталыгина О.А. Питание беременных и кормящих женщин. Решенные и нерешенные проблемы. Вопр. соврем. педиатрии. 2008; 7 (5): 23–9.
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8. Lennard L. Methyltransferases. In: Guengerich FP (ed) Bio-transformation. Comprehensive toxicology, 2010; 4 (Chap 21). Elsevier, Oxford, UK.
9. Wu X, Zou T, Cao N et al. Plasma homocysteine levels and genetic polymorphisms in folate metablism are associated with breast cancer risk in chinese women. Hered Cancer Clin Pract 2014; 12 (1): 2.
10. Berenson AB, Rahman M. Effect of hormonal contraceptives on vitamin B12 leveland the association of the latter with bonemineraldensity. Contraception 2012; 86 (5): 481–7.
11. Monteiro JP, Wise C, Morine MJ et al. Methylation potential associated with diet, genotype, protein, and metabolite levels in the Delta Obesity Vitamin Study. Genes Nutr 2014; 9: 403–22.
12. Baumgartner MR. Vitamin-responsive disorders: cobalamin, folate, biotin, vitamins B1 and E. Handb Clin Neurol 2013; 113: 1799–10.
13. Abe I, Shirato Y, Hashizume Y et al. Folate-deficiency induced cell-specific changes in the distribution of lymphocytes and granulocytes in rats. Environ Health Prev Med 2013; 18: 78–84.
14. Mujawar SA, Patil VW, Daver RG. Study of serum homocysteine, folic acid and vitamin B12 in patients with preeclampsia. Indian J Clin Biochem 2011; 26 (3): 257–60.
15. Rodriguez-Guillen MR, Torres-Sánchez L, Chen J et al. Hernández-Valero, Lizbeth López-Carrillo. Dietary consumption of B vitamins, maternal MTHFR polymorphisms and risk for spontaneous abortion. Salud Publica Mex 2009; 51 (1): 19–25.
16. Schmidt RJ, Tancredi DJ, Ozonoff S et al. Maternal periconceptionalfolic acid intake and risk of autism spectrum disorders and developmental delay in the CHARGE (CHildhoodAutism Risks from Genetics and Environment) case-control study. Am J Clin Nutr 2012; 96 (1): 80–9.
17. Orjuela MA, Cabrera-Muñoz L, Paul L et al. Risk of retinoblastoma is associated with a maternal polymorphism in dihydrofolatereductase (DHFR) and prenatal folic acid intake. Cancer 2012; 118 (23): 5912–19.
18. De-Regil LM, Fernández-Gaxiola AC, Dowswell T, Peña-Rosas JP. Effects and safety of periconceptionalfolate supplementation for preventing birth defects. Cochrane Database Syst Rev 2010; 10: CD007950.
19. Imbard A, Benoist J-F, Blom HJ. Neural Tube Defects, Folic Acid and Methylation. Int J Environ Res Public Health 2013; 10 (9): 4352–89.
20. Mosley BS, Cleves MA, Siega-Riz AM et al. Neural tube defects and maternal folate intake among pregnancies conceived after folic acid fortification in the United States. Am J Epidemiol 2009; 169: 9–17.
21. Oyama K. Folic acid prevents congenital malformations in the offspring of diabetic mice. Endocr J 2009; 56 (1): 29–37.
22. Громова О.А., Торшин И.Ю., Тетруашвили Н.К., Сидельникова В.М. Нутрициальный подход к профилактике избыточной массы тела новорожденных. Гинекология. 2010; 12 (5): 56–61.
23. Krawinkel MB, Strohm D, Weissenborn A et al. Revised D-A-CH intake recommendations for folate: how much is needed? Eur J Clin Nutr 2014; 68 (6): 719–23.
24. Громова О.А., Торшин И.Ю. Применение фолиевой кислоты в акушерстве и гинекологии. М.: РСЦ ЮНЕСКО, 2009.
25. Bailey SW, Ayling JE. Rapid folate repletion: an adjunct approach for reduction of risk for neural tube and other birth defects. Abstr 18th World Congr Controvers Obstet Gynecol Infert 2013; 90.
26. Brämswig S, Prinz-Langenohl R, Lamers Y et al. Supplementation with a multivitamin containing 800 microg of folic acid shortens the time to reach the preventive red blood cell folate concentration in healthy women. Int J Vitam Nutr Res 2009; 79 (2): 61–70.
27. Yoshino K, Nishide M, Sankai T et al. Validity of brief food frequency questionnaire for estimation of dietary intakes of folate, vitamins B6 and B12, and their associations with plasma homocysteine concentrations. Int J Food Sci Nutr 2010; 61 (1): 61–7.
28. Scaglione F, Panzavolta G. Folate, folicacidand 5-methyltetrahydrofolate are notthesamething. Xenobiotica 2014; 44 (5): 480–8.
29. Molloy AM, Kirke PN, Troendle JF. Maternal vitamin B12 status and risk of neural tube defects in a population with high neural tube defect prevalence and no folic Acid fortification. Pediatrics 2009; 123 (3): 917–23.
30. Zhang T, Xin R, Gu X, Wang F. Maternal serum vitamin B12, folate and homocysteine and the risk of neural tube defects in the offspring in a high-risk area of China. Public Health Nutr 2009; 12 (5): 68086.
31. Chan J, Deng L, Mikael LG. Low dietary choline and low dietary riboflavin during pregnancy influence reproductive outcomes and heart development in mice. Am J Clin Nutr 2010; 91 (4): 1035–43.
32. Robitaille J, Carmichael SL, Shaw GM, Olney RS. Maternal nutrient intake and risks for transverse and longitudinal limb deficiencies: data from the National Birth Defects Prevention Study, 1997–2003. Birth Defects Res A Clin Mol Teratol 2009; 85 (9): 773–9.
33. Wallenstein MB, Shaw GM, Yang W, Carmichael SL. Periconceptional nutrient intakes and risks of orofacial clefts in California. Pediatr Res 2013; 74 (4): 457–65.
34. Shaw GM, Carmichael SL, Yang W, Lammer EJ. Periconceptional nutrient intakes and risks of conotruncal heart defects. Birth Defects Res A Clin Mol Teratol 2010; 88 (3): 144–51.
35. Nakajima Y1, Imanaka-Yoshida K. New insights into the developmental mechanisms of coronary vessels and epicardium. Int Rev Cell Mol Biol 2013; 303: 263–317.
36. Hill B, Holroyd R, Sullivan M. Clinical and pathological findings associated with congenital hypovitaminosis A in extensively grazed beef cattle. Aust Vet J 2009; 87 (3): 94–8.
37. Clagett-Dame M, Knutson D. Vitamin A in Reproduction and Development. Nutrients 2011; 3 (4): 385–428.
38. Beurskens LW, Tibboel D, Retinol status of newborn infants is associated with congenital diaphragmatic hernia. Pediatrics 2010; 126 (4): 712–20.
39. Chen K, Zhang X, Wei XP. Antioxidant vitamin status during pregnancy in relation to cognitive development in the first two years of life. Early Hum Dev 2009; 85 (7): 421–7.
40. Askin DF, Diehl-Jones W. Pathogenesis and prevention of chronic lung disease in the neonate. Crit Care Nurs Clin North Am 2009; 21 (1): 11–25.
41. Thorne-Lyman AL, Fawzi WW. Vitamin A and carotenoids during pregnancy and maternal, neonatal and infant health outcomes: A systematic review and meta-analysis. Paediatr Perinat Epidemiol 2012; 26 (1): 10.1111/j.1365-3016.2012.01284.x.
42. Dheen ST, Tay SS. Recent studies on neural tube defects in embryos of diabetic pregnancy: an overview. Curr Med Chem 2009; 16 (18): 2345–54.
43. Carmichael SL, Rasmussen SA, Lammer EJ et al. Craniosynostosis and nutrient intake during pregnancy. Birth Defects Res A Clin Mol Teratol 2010; 88 (12): 1032–9.
44. Mulligan ML, Felton SK, Riek AE, Bernal-Mizrachi C. Implications of vitamin D deficiency in pregnancy and lactation. Am J Obstet Gynecol 2009; 202 (5): 429.
45. Houben ML, Bont L, Wilbrink B et al. Clinical prediction rule for RSV bronchiolitis in healthy newborns: Prognostic birth cohort study. Pediatrics 2011; 127: 35–41.
46. Hollis BW, Johnson D, Hulsey TC et al. Vitamin D supplementation during pregnancy: Double-blind, randomized clinical trial of safety and effectiveness. J Bone Miner Res 2011; 26: 2341–57.
47. Agarwal A, Gupta S, Sharma RK. Role of oxidative stress in female reproduction. Reprod Biol Endocrinol 2005; 3: 28.
48. Hara K, Akiyama Y. Collagen-related abnormalities, reduction in bone quality, and effects of menatetrenone in rats with a congenital ascorbic acid deficiency. J Bone Miner Metab 2009; 27 (3): 324–32.
49. Формулярная система. Федеральное руководство. М.: ГЭОТАР-Мед, 2010.
50. Munoz C, Carson AF, McCoy MA et al. Effect of supplementation with barium selenate on the fertility, prolificacy and lambing performance of hill sheep. Vet Rec 2009; 164 (9): 265–71.
51. Kasimanickam RK, Kasimanickam VR, Rodriguez JS et al. Tocopherol induced angiogenesis in placental vascular network in late pregnant ewes. Reprod Biol Endocrinol 2010; 8: 86.
52. Klemmensen A, Tabor A, Osterdal ML. Intake of vitamin C and E in pregnancy and risk of pre-eclampsia: prospective study among 57346 women. BJOG 2009; 116 (7): 964–74.
53. Saffery R, Ellis J, Morley R. A convergent model for placental dysfunction encompassing combined sub-optimal one-carbon donor and vitamin D bioavailability. Med Hypotheses 2009; 73 (6): 1023–8.
54. Wagner CL, Taylor SN, Dawodu A et al. Vitamin D and Its Role During Pregnancy in Attaining Optimal Health of Mother and Fetus. Nutrients 2012; 4 (3): 208–230.
55. James MF. Magnesium in obstetrics. Best Pract Res Clin Obstet Gynec 2010; 24 (3): 327–37.
56. Стуров Н.В. Некоторые аспекты применения пероральных препаратов магния. Трудный пациент. 2012; 7: 28–31.
57. Недогода С.В. Роль препаратов магния в ведении пациентов терапевтического профиля. Лечащий врач. 2009; 6: 16–9.
58. Буданова М.В., Асланова П.А., Буданов П.В. Клинические проявления и эффекты коррекции дефицита магния у детей. Трудный пациент. 2009; 1–2: 17–22.
59. Шмаков Р.Г. Применение магния в акушерстве. Лечащий врач. 2010; 11: 15–20.
Авторы
И.В.Кузнецова1, В.А.Коновалов2, 3
1. ГБОУ ВПО Первый Московский государственный медицинский университет им. И.М.Сеченова Минздрава России;
2. ФДПО ГБОУ ВПО Рязанский государственный медицинский университет им. акад. И.П.Павлова Минздрава России;
3. ГБУ РО Женская консультация №1, Рязань
1. ГБОУ ВПО Первый Московский государственный медицинский университет им. И.М.Сеченова Минздрава России;
2. ФДПО ГБОУ ВПО Рязанский государственный медицинский университет им. акад. И.П.Павлова Минздрава России;
3. ГБУ РО Женская консультация №1, Рязань
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Цель портала OmniDoctor – предоставление профессиональной информации врачам, провизорам и фармацевтам.