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Место и роль микоплазменной инфекции в структуре воспалительных заболеваний органов малого таза
Место и роль микоплазменной инфекции в структуре воспалительных заболеваний органов малого таза
Кузьмин В.Н. Место и роль микоплазменной инфекции в структуре воспалительных заболеваний органов малого таза. Гинекология.2015; 17 (2): 21–26.
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Аннотация
Представлены новые методы диагностики, лечения и разные варианты подходов к микоплазменной инфекции в гинекологии. Определены понятия формы микоплазменной инфекции с учетом патогенной и условно-патогенной формы. Раскрыты особенности резистентности к антибактериальным препаратам в лечении микстинфекции. Проведены параллели с нарушением микрофлоры и дисбиозом влагалища.
Ключевые слова: микоплазменная инфекция, уреамикоплазменная инфекция, микстинфекция, дисбиоз влагалища, резистентность.
Key words: mycoplasma infection, ureamikoplazmennaya infection, mixed infection, vaginal dysbiosis, resistance.
Ключевые слова: микоплазменная инфекция, уреамикоплазменная инфекция, микстинфекция, дисбиоз влагалища, резистентность.
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Key words: mycoplasma infection, ureamikoplazmennaya infection, mixed infection, vaginal dysbiosis, resistance.
Полный текст
Список литературы
1. Прилепская В.Н. Инфекции, передающиеся половым путем.
М., 2014. / Prilepskaia V.N. Infektsii, peredaiushchiesia polovym putem. M., 2014. [in Russian]
2. Протоколы ведения больных. Инфекции, передаваемые половым путем. Стандарт Формулярного комитета РАМН. М., 2014. / Protokoly vedeniia bol'nykh. Infektsii, peredavaemye polovym putem. Standart Formuliarnogo komiteta RAMN. M., 2014. [in Russian]
3. Филатов Н.Н., Щербо С.Н., Макаров В.Б. Эпидемиологическое исследование распространенности заболеваний, передаваемых половым путем, среди населения г. Москвы с использованием метода полимеразной цепной реакции. Тезисы докладов 3-й Всероссийской научно-практической конференции «Генодиагностика в современной медицине». М., 2000; с. 50–1. / Filatov N.N., Shcherbo S.N., Makarov V.B. Epidemiologicheskoe issledovanie rasprostranennosti zabolevanii, peredavaemykh polovym putem, sredi naseleniia g. Moskvy s ispol'zovaniem metoda polimeraznoi tsepnoi reaktsii. Tezisy dokladov 3-i Vserossiiskoi nauchno-prakticheskoi konferentsii «Genodiagnostika v sovremennoi meditsine». M., 2000; s. 50–1. [in Russian]
4. Aujard Y, Maury L et al. Ureaplasma urealyticum and Mycoplasma hominis infections in newborns: personal data and review of the literature. 2005.
5. Hardy RD. Mycoplasma Infections. ACP Medicine, 2005.
6. Кузьмин В.Н. Лечение воспалительных заболеваний органов малого таза. Лечащий врач. 2007; 10: 50–6. / Kuz'min V.N. Lechenie vospalitel'nykh zabolevanii organov malogo taza. Lechashchii vrach. 2007; 10: 50–6. [in Russian]
7. Soper DE. Pelvic inflammatory disease. Obstet Gynecol 2010; 116 (6): 1459–60.
8. Larsen B, Hwang J. Mycoplasma, Ureaplasma, and adverse pregnancy outcomes: a fresh look. Infect Dis Obstet Gynecol 2010. pii: 521921. Epub 2010 Jul 12.
9. Taylor-Robinson D. Mycoplasma genitalium: an update. Int J STD AIDS 2002; 13: 145.
10. Twin J, Taylor N, Garland SM et al. Comparison of Two Mycoplasma genitalium Real-Time PCR Detection Methodologies. J Clin Microbiol 2011; 49 (3): 1140–2.
11. Povlsen K, Thorsen P, Lind I. Relationship of Ureaplasma urealyticum biovars to the presence or absence of bacterial vaginosis in pregnant women and to the time of delivery. Eur J Clin Microbiol Infect Dis 2001; 20: 65–7.
12. Manhart LE, Kay N. Mycoplasma genitalium: Is It a Sexually Transmitted Pathogen? Curr Infect Dis Rep 2010; 12 (4): 306–13.
13. Wang N. Epidemiological study on mycoplasmas colonization and infection in the female genital tract. Zhonghua Liu Xing Bing Xue Za Zhi 1992; 13 (6): 368–71.
14. Keane FE, Thomas BJ, Gilroy CB et al. The association of Mycoplasma hominis, Ureaplasma urealyticum and Mycoplasma genitalium with bacterial vaginosis: observations on heterosexual women and their male partners. Int J STD AIDS 2000; 11 (6): 356–60.
15. Schelonka RL et al. Critical appraisal оf the role оf Ureaplasma in thet development of bronchopulmonale dysplasia with metaanalytic technigues. 2005.
16. Witt A, Berger A, Gruber CJ et al. Increased intrauterine frequency of Ureaplasma urealyticum in women with preterm labor and preterm premature rupture of the membranes and subsequent cesarean delivery. Am J Obstet Gynecol 2005; 193 (5): 1663–9.
17. Гомберг М.А., Соловьев А.М. Лечение уреаплазменной инфекции урогенитального тракта. Лечащий врач. 2004; 10: 39–42. / Gomberg M.A., Solov'ev A.M. Lechenie ureaplazmennoi infektsii urogenital'nogo trakta. Lechashchii vrach. 2004; 10: 39–42. [in Russian]
18. Bradshaw CS, Chen MY, Fairley CK. Persistence of Mycoplasma genitalium following azithromycin therapy. PLoS One 2008; 3 (11): e3618.
19. Ekiel A, Jozwiak J, Martirosian G. Mycoplasma genitalium: a significant urogenital pathogen ? Med Sci Monit 2009; 15 (4): RA102–6.
20. Elias M, Grzesko J, Siejkowski R et al. The presence of Mycoplasma hominis and Ureaplasma urealyticum in the cervical canal of uterus. Ginekol Pol 2005; 76 (1): 28–32.
2. Протоколы ведения больных. Инфекции, передаваемые половым путем. Стандарт Формулярного комитета РАМН. М., 2014. / Protokoly vedeniia bol'nykh. Infektsii, peredavaemye polovym putem. Standart Formuliarnogo komiteta RAMN. M., 2014. [in Russian]
3. Filatov N.N., Shcherbo S.N., Makarov V.B. Epidemiologicheskoe issledovanie rasprostranennosti zabolevanii, peredavaemykh polovym putem, sredi naseleniia g. Moskvy s ispol'zovaniem metoda polimeraznoi tsepnoi reaktsii. Tezisy dokladov 3-i Vserossiiskoi nauchno-prakticheskoi konferentsii «Genodiagnostika v sovremennoi meditsine». M., 2000; s. 50–1. [in Russian]
4. Aujard Y, Maury L et al. Ureaplasma urealyticum and Mycoplasma hominis infections in newborns: personal data and review of the literature. 2005.
5. Hardy RD. Mycoplasma Infections. ACP Medicine, 2005.
6. Kuz'min V.N. Lechenie vospalitel'nykh zabolevanii organov malogo taza. Lechashchii vrach. 2007; 10: 50–6. [in Russian]
7. Soper DE. Pelvic inflammatory disease. Obstet Gynecol 2010; 116 (6): 1459–60.
8. Larsen B, Hwang J. Mycoplasma, Ureaplasma, and adverse pregnancy outcomes: a fresh look. Infect Dis Obstet Gynecol 2010. pii: 521921. Epub 2010 Jul 12.
9. Taylor-Robinson D. Mycoplasma genitalium: an update. Int J STD AIDS 2002; 13: 145.
10. Twin J, Taylor N, Garland SM et al. Comparison of Two Mycoplasma genitalium Real-Time PCR Detection Methodologies. J Clin Microbiol 2011; 49 (3): 1140–2.
11. Povlsen K, Thorsen P, Lind I. Relationship of Ureaplasma urealyticum biovars to the presence or absence of bacterial vaginosis in pregnant women and to the time of delivery. Eur J Clin Microbiol Infect Dis 2001; 20: 65–7.
12. Manhart LE, Kay N. Mycoplasma genitalium: Is It a Sexually Transmitted Pathogen? Curr Infect Dis Rep 2010; 12 (4): 306–13.
13. Wang N. Epidemiological study on mycoplasmas colonization and infection in the female genital tract. Zhonghua Liu Xing Bing Xue Za Zhi 1992; 13 (6): 368–71.
14. Keane FE, Thomas BJ, Gilroy CB et al. The association of Mycoplasma hominis, Ureaplasma urealyticum and Mycoplasma genitalium with bacterial vaginosis: observations on heterosexual women and their male partners. Int J STD AIDS 2000; 11 (6): 356–60.
15. Schelonka RL et al. Critical appraisal оf the role оf Ureaplasma in thet development of bronchopulmonale dysplasia with metaanalytic technigues. 2005.
16. Witt A, Berger A, Gruber CJ et al. Increased intrauterine frequency of Ureaplasma urealyticum in women with preterm labor and preterm premature rupture of the membranes and subsequent cesarean delivery. Am J Obstet Gynecol 2005; 193 (5): 1663–9.
17. Gomberg M.A., Solov'ev A.M. Lechenie ureaplazmennoi infektsii urogenital'nogo trakta. Lechashchii vrach. 2004; 10: 39–42. [in Russian]
18. Bradshaw CS, Chen MY, Fairley CK. Persistence of Mycoplasma genitalium following azithromycin therapy. PLoS One 2008; 3 (11): e3618.
19. Ekiel A, Jozwiak J, Martirosian G. Mycoplasma genitalium: a significant urogenital pathogen ? Med Sci Monit 2009; 15 (4): RA102–6.
20. Elias M, Grzesko J, Siejkowski R et al. The presence of Mycoplasma hominis and Ureaplasma urealyticum in the cervical canal of uterus. Ginekol Pol 2005; 76 (1): 28–32.
М., 2014. / Prilepskaia V.N. Infektsii, peredaiushchiesia polovym putem. M., 2014. [in Russian]
2. Протоколы ведения больных. Инфекции, передаваемые половым путем. Стандарт Формулярного комитета РАМН. М., 2014. / Protokoly vedeniia bol'nykh. Infektsii, peredavaemye polovym putem. Standart Formuliarnogo komiteta RAMN. M., 2014. [in Russian]
3. Филатов Н.Н., Щербо С.Н., Макаров В.Б. Эпидемиологическое исследование распространенности заболеваний, передаваемых половым путем, среди населения г. Москвы с использованием метода полимеразной цепной реакции. Тезисы докладов 3-й Всероссийской научно-практической конференции «Генодиагностика в современной медицине». М., 2000; с. 50–1. / Filatov N.N., Shcherbo S.N., Makarov V.B. Epidemiologicheskoe issledovanie rasprostranennosti zabolevanii, peredavaemykh polovym putem, sredi naseleniia g. Moskvy s ispol'zovaniem metoda polimeraznoi tsepnoi reaktsii. Tezisy dokladov 3-i Vserossiiskoi nauchno-prakticheskoi konferentsii «Genodiagnostika v sovremennoi meditsine». M., 2000; s. 50–1. [in Russian]
4. Aujard Y, Maury L et al. Ureaplasma urealyticum and Mycoplasma hominis infections in newborns: personal data and review of the literature. 2005.
5. Hardy RD. Mycoplasma Infections. ACP Medicine, 2005.
6. Кузьмин В.Н. Лечение воспалительных заболеваний органов малого таза. Лечащий врач. 2007; 10: 50–6. / Kuz'min V.N. Lechenie vospalitel'nykh zabolevanii organov malogo taza. Lechashchii vrach. 2007; 10: 50–6. [in Russian]
7. Soper DE. Pelvic inflammatory disease. Obstet Gynecol 2010; 116 (6): 1459–60.
8. Larsen B, Hwang J. Mycoplasma, Ureaplasma, and adverse pregnancy outcomes: a fresh look. Infect Dis Obstet Gynecol 2010. pii: 521921. Epub 2010 Jul 12.
9. Taylor-Robinson D. Mycoplasma genitalium: an update. Int J STD AIDS 2002; 13: 145.
10. Twin J, Taylor N, Garland SM et al. Comparison of Two Mycoplasma genitalium Real-Time PCR Detection Methodologies. J Clin Microbiol 2011; 49 (3): 1140–2.
11. Povlsen K, Thorsen P, Lind I. Relationship of Ureaplasma urealyticum biovars to the presence or absence of bacterial vaginosis in pregnant women and to the time of delivery. Eur J Clin Microbiol Infect Dis 2001; 20: 65–7.
12. Manhart LE, Kay N. Mycoplasma genitalium: Is It a Sexually Transmitted Pathogen? Curr Infect Dis Rep 2010; 12 (4): 306–13.
13. Wang N. Epidemiological study on mycoplasmas colonization and infection in the female genital tract. Zhonghua Liu Xing Bing Xue Za Zhi 1992; 13 (6): 368–71.
14. Keane FE, Thomas BJ, Gilroy CB et al. The association of Mycoplasma hominis, Ureaplasma urealyticum and Mycoplasma genitalium with bacterial vaginosis: observations on heterosexual women and their male partners. Int J STD AIDS 2000; 11 (6): 356–60.
15. Schelonka RL et al. Critical appraisal оf the role оf Ureaplasma in thet development of bronchopulmonale dysplasia with metaanalytic technigues. 2005.
16. Witt A, Berger A, Gruber CJ et al. Increased intrauterine frequency of Ureaplasma urealyticum in women with preterm labor and preterm premature rupture of the membranes and subsequent cesarean delivery. Am J Obstet Gynecol 2005; 193 (5): 1663–9.
17. Гомберг М.А., Соловьев А.М. Лечение уреаплазменной инфекции урогенитального тракта. Лечащий врач. 2004; 10: 39–42. / Gomberg M.A., Solov'ev A.M. Lechenie ureaplazmennoi infektsii urogenital'nogo trakta. Lechashchii vrach. 2004; 10: 39–42. [in Russian]
18. Bradshaw CS, Chen MY, Fairley CK. Persistence of Mycoplasma genitalium following azithromycin therapy. PLoS One 2008; 3 (11): e3618.
19. Ekiel A, Jozwiak J, Martirosian G. Mycoplasma genitalium: a significant urogenital pathogen ? Med Sci Monit 2009; 15 (4): RA102–6.
20. Elias M, Grzesko J, Siejkowski R et al. The presence of Mycoplasma hominis and Ureaplasma urealyticum in the cervical canal of uterus. Ginekol Pol 2005; 76 (1): 28–32.
________________________________________________
2. Протоколы ведения больных. Инфекции, передаваемые половым путем. Стандарт Формулярного комитета РАМН. М., 2014. / Protokoly vedeniia bol'nykh. Infektsii, peredavaemye polovym putem. Standart Formuliarnogo komiteta RAMN. M., 2014. [in Russian]
3. Filatov N.N., Shcherbo S.N., Makarov V.B. Epidemiologicheskoe issledovanie rasprostranennosti zabolevanii, peredavaemykh polovym putem, sredi naseleniia g. Moskvy s ispol'zovaniem metoda polimeraznoi tsepnoi reaktsii. Tezisy dokladov 3-i Vserossiiskoi nauchno-prakticheskoi konferentsii «Genodiagnostika v sovremennoi meditsine». M., 2000; s. 50–1. [in Russian]
4. Aujard Y, Maury L et al. Ureaplasma urealyticum and Mycoplasma hominis infections in newborns: personal data and review of the literature. 2005.
5. Hardy RD. Mycoplasma Infections. ACP Medicine, 2005.
6. Kuz'min V.N. Lechenie vospalitel'nykh zabolevanii organov malogo taza. Lechashchii vrach. 2007; 10: 50–6. [in Russian]
7. Soper DE. Pelvic inflammatory disease. Obstet Gynecol 2010; 116 (6): 1459–60.
8. Larsen B, Hwang J. Mycoplasma, Ureaplasma, and adverse pregnancy outcomes: a fresh look. Infect Dis Obstet Gynecol 2010. pii: 521921. Epub 2010 Jul 12.
9. Taylor-Robinson D. Mycoplasma genitalium: an update. Int J STD AIDS 2002; 13: 145.
10. Twin J, Taylor N, Garland SM et al. Comparison of Two Mycoplasma genitalium Real-Time PCR Detection Methodologies. J Clin Microbiol 2011; 49 (3): 1140–2.
11. Povlsen K, Thorsen P, Lind I. Relationship of Ureaplasma urealyticum biovars to the presence or absence of bacterial vaginosis in pregnant women and to the time of delivery. Eur J Clin Microbiol Infect Dis 2001; 20: 65–7.
12. Manhart LE, Kay N. Mycoplasma genitalium: Is It a Sexually Transmitted Pathogen? Curr Infect Dis Rep 2010; 12 (4): 306–13.
13. Wang N. Epidemiological study on mycoplasmas colonization and infection in the female genital tract. Zhonghua Liu Xing Bing Xue Za Zhi 1992; 13 (6): 368–71.
14. Keane FE, Thomas BJ, Gilroy CB et al. The association of Mycoplasma hominis, Ureaplasma urealyticum and Mycoplasma genitalium with bacterial vaginosis: observations on heterosexual women and their male partners. Int J STD AIDS 2000; 11 (6): 356–60.
15. Schelonka RL et al. Critical appraisal оf the role оf Ureaplasma in thet development of bronchopulmonale dysplasia with metaanalytic technigues. 2005.
16. Witt A, Berger A, Gruber CJ et al. Increased intrauterine frequency of Ureaplasma urealyticum in women with preterm labor and preterm premature rupture of the membranes and subsequent cesarean delivery. Am J Obstet Gynecol 2005; 193 (5): 1663–9.
17. Gomberg M.A., Solov'ev A.M. Lechenie ureaplazmennoi infektsii urogenital'nogo trakta. Lechashchii vrach. 2004; 10: 39–42. [in Russian]
18. Bradshaw CS, Chen MY, Fairley CK. Persistence of Mycoplasma genitalium following azithromycin therapy. PLoS One 2008; 3 (11): e3618.
19. Ekiel A, Jozwiak J, Martirosian G. Mycoplasma genitalium: a significant urogenital pathogen ? Med Sci Monit 2009; 15 (4): RA102–6.
20. Elias M, Grzesko J, Siejkowski R et al. The presence of Mycoplasma hominis and Ureaplasma urealyticum in the cervical canal of uterus. Ginekol Pol 2005; 76 (1): 28–32.
Авторы
В.Н.Кузьмин*
ГБОУ ВПО Московский государственный медико-стоматологический университет им. А.И.Евдокимова Минздрава России. 127473, Россия, Москва, ул. Делегатская, д. 20, стр. 1
*vnkuzmin@mail.ru
A.I. Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of the Russian Federation.
127473, Russian Federation, Moscow, ul. Delegatskaia, d. 20, str. 1
*vnkuzmin@mail.ru
ГБОУ ВПО Московский государственный медико-стоматологический университет им. А.И.Евдокимова Минздрава России. 127473, Россия, Москва, ул. Делегатская, д. 20, стр. 1
*vnkuzmin@mail.ru
________________________________________________
A.I. Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of the Russian Federation.
127473, Russian Federation, Moscow, ul. Delegatskaia, d. 20, str. 1
*vnkuzmin@mail.ru
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