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Рациональная контрацепция: как свести риск к минимуму?
Рациональная контрацепция: как свести риск к минимуму?
Кирющенков П.А., Тамбовцева М.А. Рациональная контрацепция: как свести к минимуму? Гинекология. 2015; 17 (2): 41–44.
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Аннотация
Применение комбинированных оральных контрацептивов, даже низко- и микродозированных, должно основываться на индивидуальной оценке степени риска развития тромботических осложнений. Целесообразно сочетать комбинированные оральные контрацептивы с поливитаминными комплексами, оказывающими влияние на систему гемостаза, в первую очередь сосудисто-эндотелиальный компонент (Дуовит® для женщин). Лечебное применение комбинированных оральных контрацептивов у женщин группы высокого риска по реализации тромбозов возможно одновременно с противотромботическими средствами (препаратами гепаринового ряда).
Ключевые слова: гормональная контрацепция, факторы риска, венозные тромбоэмболические осложнения, поливитаминные комплексы.
Key words: hormonal contraception, risk factors, venous thromboembolism, multivitamin complexes.
Ключевые слова: гормональная контрацепция, факторы риска, венозные тромбоэмболические осложнения, поливитаминные комплексы.
________________________________________________
Key words: hormonal contraception, risk factors, venous thromboembolism, multivitamin complexes.
Полный текст
Список литературы
1. Kubba A, Guillebaud J, Anderson RA, MacGregor EA. Contraception. Lancet 2000; 356 (9245): 1913–9.
2. Petitti DB. Clinical practice. Combination estrogen-progestin oral contraceptives. N Engl J Med 2003; 349 (15): 1443–50.
3. Руководство по контрацепции. Под ред. В.Н.Прилепской. М.: МЕДпресс-информ, 2006. / Rukovodstvo po kontratseptsii. Pod red. V.N.Prilepskoi. M.: MEDpress-inform, 2006. [in Russian]
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5. Lidegaard O, Nielsen LH, Skovlund CW, Lokkegaard E. Venous thrombosis in users of non-oral hormonal contraception: follow-upstudy, Denmark 2001–2010. BMJ 2012; 344: 2990–8.
6. Reid R, Leyland N, Wolfman W et al. SOGC clinical practice guidelines: Oral contraceptives and the risk of venous thromboembolism: an update: no. 252, December 2010. Int J Gynaecol Obstet 2011; 112 (3): 252–6.
7. Момот А.П., Тараненко И.А., Цывкина Л.П. Эволюция представлений о тромбофилии и ее роли в проблемах репродукции человека. Акуш. и гинекол. 2013; 2: 4–9. / Momot A.P., Taranenko I.A., Tsyvkina L.P. Evoliutsiia predstavlenii o trombofilii i ee roli v problemakh reproduktsii cheloveka. Akush. i ginekol. 2013; 2: 4–9. [in Russian]
8. James AH, Tapson VF, Goldhaber SZ. Thrombosis during pregnancy and the postpartum period. Am J Obstet Gynecol 2005; 193 (1): 216–9.
9. Folkeringa N, Brouwer JLP, Korteweg F et al. High risk of pregnancy-related venous thromboembolism in women with multiple thrombophilic defects. Br J Haematol 2007; 138 (1): 110–6.
10. Ray JG, Chan WS. Deep vein thrombosis during pregnancy and the puerperium: a meta-analysis of the period of risk and the leg of presentation. Obstet Gynecol Surv 1999; 54 (4): 265–71.
11. Sanson BJ, Simioni P, Tormene D et al. The incidence of venous thromboembolism in asymptomatic carriers of a deficiency of antithrombin, protein C, or protein S: a prospective cohort study. Blood 1999; 94 (11): 3702–6.
12. Зайнулина М.С., Корнюшина Е.А., Бикмуллина Д.Р. Тромбофилия: этиологический фактор или патогенетический аспект осложненного течения беременности? Журн. акушерства и женских болезней. 2010; LIX (1): 18–30. / Zainulina M.S., Korniushina E.A., Bikmullina D.R. Trombofiliia: etiologicheskii faktor ili patogeneticheskii aspekt oslozhnennogo techeniia beremennosti? Zhurn. akusherstva i zhenskikh boleznei. 2010; LIX (1): 18–30. [in Russian]
13. Sammaritano LR. Contraception in patients with systemic lupus erythematosus and antiphospholipid syndrome. Lupus 2014; 23 (12): 1242–5.
14. Hugon-Rodin J, Gompel A, Plu-Bureau G. Epidemiology of hormonal contraceptives-related venous thromboembolism. Eur J Endocrinol 2014; 171 (6): R221–30.
15. Tchaikovski SN, Rosing J. Mechanisms of estrogen-induced venous thromboembolism. Thromb Res 2010; 126 (1): 5–11.
16. Perrot-Applanat M, Cohen-Solal K, Milgrom E, Finet M. Progesterone receptor expression in human saphenous veins. Circulation 1995; 92 (10): 2975–83.
17. Veljković M, Popovć J. Venous thromboembolism and oral contraception. Med Pregl 2010; 63 (5–6): 376–9.
18. Sidney S, Petitti DB, Soff GA et al. Venous thromboembolic disease in users of low-estrogen combined estrogen-progestin oral contraceptives. Contraception 2004; 70: 3–10.
19. Stegeman BH, de Bastos M, Rosendaal FR et al. Different combined oral contraceptives and the risk of venous thrombosis: systematic review and network meta-analysis. BMJ 2013; 347: f5298.
20. De Bastos M, Stegeman BH, Rosendaal FR et al. Combined oral contraceptives: venous thrombosis. Cochrane Database of Systematic Reviews 2014; 3: CD010813.
21. Plu-Bureau G, Maitrot-Mantelet L, Hugon-Rodin J, Canonico M. Hormonal contraceptives and venous thromboembolism: an epidemiological update. Best Practice & Research. Clin Endocrinol Metab 2013; 27 (1): 25–34.
22. Martinez F, Ramirez I, Perez-Campos E et al. Venous and pulmonary thromboembolism and combined hormonal contraceptives. Systematic review and meta-analysis. Eur J Contracept Reprod Health Care 2012; 17 (1): 7–29.
23. Wu CQ, Grandi SM, Filion KB et al. Drospirenone-containing oral contraceptive pills and the risk of venous and arterial thrombosis: a systematic review. BJOG: an Int J Obstet Gynaecol 2013; 120 (7): 801–10.
24. Ших Е.В. Взаимодействие компонентов витаминно-минеральных комплексов и рациональная витаминотерапия. Consilium Mеdicum. 2004; 6 (12). / Shikh E.V. Vzaimodeistvie komponentov vitaminno-mineral'nykh kompleksov i ratsional'naia vitaminoterapiia. Consilium Medicum. 2004; 6 (12). [in Russian]
25. Zal F, Mostafavi-Pour Z, Amini F, Heidari A. Effect of vitamin E and C supplements on lipid peroxidation and GSH-dependent antioxidant enzyme status in the blood of women consuming oral contraceptives. Contraception 2012; 86 (1): 62–6.
26. Кирющенков П.А., Шмаков Р.Г., Андамова Е.В., Тамбовцева М.А. Алгоритм клинико-гемостазиологического обследования в акушерско-гинекологической практике. Акуш. и гинекол. 2013; 1: 101–6. / Kiriushchenkov P.A., Shmakov R.G., Andamova E.V., Tambovtseva M.A. Algoritm kliniko-gemostaziologicheskogo obsledovaniia v akushersko-ginekologicheskoi praktike. Akush. i ginekol. 2013; 1: 101–6. [in Russian]
2. Petitti DB. Clinical practice. Combination estrogen-progestin oral contraceptives. N Engl J Med 2003; 349 (15): 1443–50.
3. Rukovodstvo po kontratseptsii. Pod red. V.N.Prilepskoi. M.: MEDpress-inform, 2006. [in Russian]
4. Carpenter SEK, Rock JA. Paediatric and Adolescent Gynecology. Philadelphia: Lippincott WW, 2000.
5. Lidegaard O, Nielsen LH, Skovlund CW, Lokkegaard E. Venous thrombosis in users of non-oral hormonal contraception: follow-upstudy, Denmark 2001–2010. BMJ 2012; 344: 2990–8.
6. Reid R, Leyland N, Wolfman W et al. SOGC clinical practice guidelines: Oral contraceptives and the risk of venous thromboembolism: an update: no. 252, December 2010. Int J Gynaecol Obstet 2011; 112 (3): 252–6.
7. Momot A.P., Taranenko I.A., Tsyvkina L.P. Evoliutsiia predstavlenii o trombofilii i ee roli v problemakh reproduktsii cheloveka. Akush. i ginekol. 2013; 2: 4–9. [in Russian]
8. James AH, Tapson VF, Goldhaber SZ. Thrombosis during pregnancy and the postpartum period. Am J Obstet Gynecol 2005; 193 (1): 216–9.
9. Folkeringa N, Brouwer JLP, Korteweg F et al. High risk of pregnancy-related venous thromboembolism in women with multiple thrombophilic defects. Br J Haematol 2007; 138 (1): 110–6.
10. Ray JG, Chan WS. Deep vein thrombosis during pregnancy and the puerperium: a meta-analysis of the period of risk and the leg of presentation. Obstet Gynecol Surv 1999; 54 (4): 265–71.
11. Sanson BJ, Simioni P, Tormene D et al. The incidence of venous thromboembolism in asymptomatic carriers of a deficiency of antithrombin, protein C, or protein S: a prospective cohort study. Blood 1999; 94 (11): 3702–6.
12. Zainulina M.S., Korniushina E.A., Bikmullina D.R. Trombofiliia: etiologicheskii faktor ili patogeneticheskii aspekt oslozhnennogo techeniia beremennosti? Zhurn. akusherstva i zhenskikh boleznei. 2010; LIX (1): 18–30. [in Russian]
13. Sammaritano LR. Contraception in patients with systemic lupus erythematosus and antiphospholipid syndrome. Lupus 2014; 23 (12): 1242–5.
14. Hugon-Rodin J, Gompel A, Plu-Bureau G. Epidemiology of hormonal contraceptives-related venous thromboembolism. Eur J Endocrinol 2014; 171 (6): R221–30.
15. Tchaikovski SN, Rosing J. Mechanisms of estrogen-induced venous thromboembolism. Thromb Res 2010; 126 (1): 5–11.
16. Perrot-Applanat M, Cohen-Solal K, Milgrom E, Finet M. Progesterone receptor expression in human saphenous veins. Circulation 1995; 92 (10): 2975–83.
17. Veljković M, Popovć J. Venous thromboembolism and oral contraception. Med Pregl 2010; 63 (5–6): 376–9.
18. Sidney S, Petitti DB, Soff GA et al. Venous thromboembolic disease in users of low-estrogen combined estrogen-progestin oral contraceptives. Contraception 2004; 70: 3–10.
19. Stegeman BH, de Bastos M, Rosendaal FR et al. Different combined oral contraceptives and the risk of venous thrombosis: systematic review and network meta-analysis. BMJ 2013; 347: f5298.
20. De Bastos M, Stegeman BH, Rosendaal FR et al. Combined oral contraceptives: venous thrombosis. Cochrane Database of Systematic Reviews 2014; 3: CD010813.
21. Plu-Bureau G, Maitrot-Mantelet L, Hugon-Rodin J, Canonico M. Hormonal contraceptives and venous thromboembolism: an epidemiological update. Best Practice & Research. Clin Endocrinol Metab 2013; 27 (1): 25–34.
22. Martinez F, Ramirez I, Perez-Campos E et al. Venous and pulmonary thromboembolism and combined hormonal contraceptives. Systematic review and meta-analysis. Eur J Contracept Reprod Health Care 2012; 17 (1): 7–29.
23. Wu CQ, Grandi SM, Filion KB et al. Drospirenone-containing oral contraceptive pills and the risk of venous and arterial thrombosis: a systematic review. BJOG: an Int J Obstet Gynaecol 2013; 120 (7): 801–10.
24. Shikh E.V. Vzaimodeistvie komponentov vitaminno-mineral'nykh kompleksov i ratsional'naia vitaminoterapiia. Consilium Medicum. 2004; 6 (12). [in Russian]
25. Zal F, Mostafavi-Pour Z, Amini F, Heidari A. Effect of vitamin E and C supplements on lipid peroxidation and GSH-dependent antioxidant enzyme status in the blood of women consuming oral contraceptives. Contraception 2012; 86 (1): 62–6.
26. Kiriushchenkov P.A., Shmakov R.G., Andamova E.V., Tambovtseva M.A. Algoritm kliniko-gemostaziologicheskogo obsledovaniia v akushersko-ginekologicheskoi praktike. Akush. i ginekol. 2013; 1: 101–6. [in Russian]
2. Petitti DB. Clinical practice. Combination estrogen-progestin oral contraceptives. N Engl J Med 2003; 349 (15): 1443–50.
3. Руководство по контрацепции. Под ред. В.Н.Прилепской. М.: МЕДпресс-информ, 2006. / Rukovodstvo po kontratseptsii. Pod red. V.N.Prilepskoi. M.: MEDpress-inform, 2006. [in Russian]
4. Carpenter SEK, Rock JA. Paediatric and Adolescent Gynecology. Philadelphia: Lippincott WW, 2000.
5. Lidegaard O, Nielsen LH, Skovlund CW, Lokkegaard E. Venous thrombosis in users of non-oral hormonal contraception: follow-upstudy, Denmark 2001–2010. BMJ 2012; 344: 2990–8.
6. Reid R, Leyland N, Wolfman W et al. SOGC clinical practice guidelines: Oral contraceptives and the risk of venous thromboembolism: an update: no. 252, December 2010. Int J Gynaecol Obstet 2011; 112 (3): 252–6.
7. Момот А.П., Тараненко И.А., Цывкина Л.П. Эволюция представлений о тромбофилии и ее роли в проблемах репродукции человека. Акуш. и гинекол. 2013; 2: 4–9. / Momot A.P., Taranenko I.A., Tsyvkina L.P. Evoliutsiia predstavlenii o trombofilii i ee roli v problemakh reproduktsii cheloveka. Akush. i ginekol. 2013; 2: 4–9. [in Russian]
8. James AH, Tapson VF, Goldhaber SZ. Thrombosis during pregnancy and the postpartum period. Am J Obstet Gynecol 2005; 193 (1): 216–9.
9. Folkeringa N, Brouwer JLP, Korteweg F et al. High risk of pregnancy-related venous thromboembolism in women with multiple thrombophilic defects. Br J Haematol 2007; 138 (1): 110–6.
10. Ray JG, Chan WS. Deep vein thrombosis during pregnancy and the puerperium: a meta-analysis of the period of risk and the leg of presentation. Obstet Gynecol Surv 1999; 54 (4): 265–71.
11. Sanson BJ, Simioni P, Tormene D et al. The incidence of venous thromboembolism in asymptomatic carriers of a deficiency of antithrombin, protein C, or protein S: a prospective cohort study. Blood 1999; 94 (11): 3702–6.
12. Зайнулина М.С., Корнюшина Е.А., Бикмуллина Д.Р. Тромбофилия: этиологический фактор или патогенетический аспект осложненного течения беременности? Журн. акушерства и женских болезней. 2010; LIX (1): 18–30. / Zainulina M.S., Korniushina E.A., Bikmullina D.R. Trombofiliia: etiologicheskii faktor ili patogeneticheskii aspekt oslozhnennogo techeniia beremennosti? Zhurn. akusherstva i zhenskikh boleznei. 2010; LIX (1): 18–30. [in Russian]
13. Sammaritano LR. Contraception in patients with systemic lupus erythematosus and antiphospholipid syndrome. Lupus 2014; 23 (12): 1242–5.
14. Hugon-Rodin J, Gompel A, Plu-Bureau G. Epidemiology of hormonal contraceptives-related venous thromboembolism. Eur J Endocrinol 2014; 171 (6): R221–30.
15. Tchaikovski SN, Rosing J. Mechanisms of estrogen-induced venous thromboembolism. Thromb Res 2010; 126 (1): 5–11.
16. Perrot-Applanat M, Cohen-Solal K, Milgrom E, Finet M. Progesterone receptor expression in human saphenous veins. Circulation 1995; 92 (10): 2975–83.
17. Veljković M, Popovć J. Venous thromboembolism and oral contraception. Med Pregl 2010; 63 (5–6): 376–9.
18. Sidney S, Petitti DB, Soff GA et al. Venous thromboembolic disease in users of low-estrogen combined estrogen-progestin oral contraceptives. Contraception 2004; 70: 3–10.
19. Stegeman BH, de Bastos M, Rosendaal FR et al. Different combined oral contraceptives and the risk of venous thrombosis: systematic review and network meta-analysis. BMJ 2013; 347: f5298.
20. De Bastos M, Stegeman BH, Rosendaal FR et al. Combined oral contraceptives: venous thrombosis. Cochrane Database of Systematic Reviews 2014; 3: CD010813.
21. Plu-Bureau G, Maitrot-Mantelet L, Hugon-Rodin J, Canonico M. Hormonal contraceptives and venous thromboembolism: an epidemiological update. Best Practice & Research. Clin Endocrinol Metab 2013; 27 (1): 25–34.
22. Martinez F, Ramirez I, Perez-Campos E et al. Venous and pulmonary thromboembolism and combined hormonal contraceptives. Systematic review and meta-analysis. Eur J Contracept Reprod Health Care 2012; 17 (1): 7–29.
23. Wu CQ, Grandi SM, Filion KB et al. Drospirenone-containing oral contraceptive pills and the risk of venous and arterial thrombosis: a systematic review. BJOG: an Int J Obstet Gynaecol 2013; 120 (7): 801–10.
24. Ших Е.В. Взаимодействие компонентов витаминно-минеральных комплексов и рациональная витаминотерапия. Consilium Mеdicum. 2004; 6 (12). / Shikh E.V. Vzaimodeistvie komponentov vitaminno-mineral'nykh kompleksov i ratsional'naia vitaminoterapiia. Consilium Medicum. 2004; 6 (12). [in Russian]
25. Zal F, Mostafavi-Pour Z, Amini F, Heidari A. Effect of vitamin E and C supplements on lipid peroxidation and GSH-dependent antioxidant enzyme status in the blood of women consuming oral contraceptives. Contraception 2012; 86 (1): 62–6.
26. Кирющенков П.А., Шмаков Р.Г., Андамова Е.В., Тамбовцева М.А. Алгоритм клинико-гемостазиологического обследования в акушерско-гинекологической практике. Акуш. и гинекол. 2013; 1: 101–6. / Kiriushchenkov P.A., Shmakov R.G., Andamova E.V., Tambovtseva M.A. Algoritm kliniko-gemostaziologicheskogo obsledovaniia v akushersko-ginekologicheskoi praktike. Akush. i ginekol. 2013; 1: 101–6. [in Russian]
________________________________________________
2. Petitti DB. Clinical practice. Combination estrogen-progestin oral contraceptives. N Engl J Med 2003; 349 (15): 1443–50.
3. Rukovodstvo po kontratseptsii. Pod red. V.N.Prilepskoi. M.: MEDpress-inform, 2006. [in Russian]
4. Carpenter SEK, Rock JA. Paediatric and Adolescent Gynecology. Philadelphia: Lippincott WW, 2000.
5. Lidegaard O, Nielsen LH, Skovlund CW, Lokkegaard E. Venous thrombosis in users of non-oral hormonal contraception: follow-upstudy, Denmark 2001–2010. BMJ 2012; 344: 2990–8.
6. Reid R, Leyland N, Wolfman W et al. SOGC clinical practice guidelines: Oral contraceptives and the risk of venous thromboembolism: an update: no. 252, December 2010. Int J Gynaecol Obstet 2011; 112 (3): 252–6.
7. Momot A.P., Taranenko I.A., Tsyvkina L.P. Evoliutsiia predstavlenii o trombofilii i ee roli v problemakh reproduktsii cheloveka. Akush. i ginekol. 2013; 2: 4–9. [in Russian]
8. James AH, Tapson VF, Goldhaber SZ. Thrombosis during pregnancy and the postpartum period. Am J Obstet Gynecol 2005; 193 (1): 216–9.
9. Folkeringa N, Brouwer JLP, Korteweg F et al. High risk of pregnancy-related venous thromboembolism in women with multiple thrombophilic defects. Br J Haematol 2007; 138 (1): 110–6.
10. Ray JG, Chan WS. Deep vein thrombosis during pregnancy and the puerperium: a meta-analysis of the period of risk and the leg of presentation. Obstet Gynecol Surv 1999; 54 (4): 265–71.
11. Sanson BJ, Simioni P, Tormene D et al. The incidence of venous thromboembolism in asymptomatic carriers of a deficiency of antithrombin, protein C, or protein S: a prospective cohort study. Blood 1999; 94 (11): 3702–6.
12. Zainulina M.S., Korniushina E.A., Bikmullina D.R. Trombofiliia: etiologicheskii faktor ili patogeneticheskii aspekt oslozhnennogo techeniia beremennosti? Zhurn. akusherstva i zhenskikh boleznei. 2010; LIX (1): 18–30. [in Russian]
13. Sammaritano LR. Contraception in patients with systemic lupus erythematosus and antiphospholipid syndrome. Lupus 2014; 23 (12): 1242–5.
14. Hugon-Rodin J, Gompel A, Plu-Bureau G. Epidemiology of hormonal contraceptives-related venous thromboembolism. Eur J Endocrinol 2014; 171 (6): R221–30.
15. Tchaikovski SN, Rosing J. Mechanisms of estrogen-induced venous thromboembolism. Thromb Res 2010; 126 (1): 5–11.
16. Perrot-Applanat M, Cohen-Solal K, Milgrom E, Finet M. Progesterone receptor expression in human saphenous veins. Circulation 1995; 92 (10): 2975–83.
17. Veljković M, Popovć J. Venous thromboembolism and oral contraception. Med Pregl 2010; 63 (5–6): 376–9.
18. Sidney S, Petitti DB, Soff GA et al. Venous thromboembolic disease in users of low-estrogen combined estrogen-progestin oral contraceptives. Contraception 2004; 70: 3–10.
19. Stegeman BH, de Bastos M, Rosendaal FR et al. Different combined oral contraceptives and the risk of venous thrombosis: systematic review and network meta-analysis. BMJ 2013; 347: f5298.
20. De Bastos M, Stegeman BH, Rosendaal FR et al. Combined oral contraceptives: venous thrombosis. Cochrane Database of Systematic Reviews 2014; 3: CD010813.
21. Plu-Bureau G, Maitrot-Mantelet L, Hugon-Rodin J, Canonico M. Hormonal contraceptives and venous thromboembolism: an epidemiological update. Best Practice & Research. Clin Endocrinol Metab 2013; 27 (1): 25–34.
22. Martinez F, Ramirez I, Perez-Campos E et al. Venous and pulmonary thromboembolism and combined hormonal contraceptives. Systematic review and meta-analysis. Eur J Contracept Reprod Health Care 2012; 17 (1): 7–29.
23. Wu CQ, Grandi SM, Filion KB et al. Drospirenone-containing oral contraceptive pills and the risk of venous and arterial thrombosis: a systematic review. BJOG: an Int J Obstet Gynaecol 2013; 120 (7): 801–10.
24. Shikh E.V. Vzaimodeistvie komponentov vitaminno-mineral'nykh kompleksov i ratsional'naia vitaminoterapiia. Consilium Medicum. 2004; 6 (12). [in Russian]
25. Zal F, Mostafavi-Pour Z, Amini F, Heidari A. Effect of vitamin E and C supplements on lipid peroxidation and GSH-dependent antioxidant enzyme status in the blood of women consuming oral contraceptives. Contraception 2012; 86 (1): 62–6.
26. Kiriushchenkov P.A., Shmakov R.G., Andamova E.V., Tambovtseva M.A. Algoritm kliniko-gemostaziologicheskogo obsledovaniia v akushersko-ginekologicheskoi praktike. Akush. i ginekol. 2013; 1: 101–6. [in Russian]
Авторы
П.А.Кирющенков*, М.А.Тамбовцева
ФГБУ Научный центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова Минздрава России. 117997, Россия, Москва, ул. Академика Опарина, д. 4
*masha-kirmail@mail.ru
Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation.
117997, Russian Federation, Moscow, ul. Akademika Oparina, d. 4
*masha-kirmail@mail.ru
ФГБУ Научный центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова Минздрава России. 117997, Россия, Москва, ул. Академика Опарина, д. 4
*masha-kirmail@mail.ru
________________________________________________
Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation.
117997, Russian Federation, Moscow, ul. Akademika Oparina, d. 4
*masha-kirmail@mail.ru
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