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Выбор триггера овуляции для оптимизации программ экстракорпорального оплодотворения (обзор литературы)
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Eapen S.M., Mishiyeva N.G., Martazanova B.A. et al. Choosing trigger of ovulation for optimization of in vitro fertilization programs (literature review).
Gynecology. 2016; 18 (1): 84–87.
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Ключевые слова: агонисты гонадотропин-рилизинг-гормона, хорионический гонадотропин человека, вспомогательные репродуктивные технологии, синдром гиперстимуляции яичников, триггер овуляции.
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This review presents recent data on the impact of different triggers on the clinical and embryological indicators of the effectiveness of assisted reproductive technology in patients with normal and excessive ovarian response to superovulation. Triggering with gonadotropin releasing hormone agonist can be a real alternative to human chorionic gonadotropin triggering: gonadotropin-releasing hormone agonists trigger reduces the risk of ovarian hyperstimulation syndrome. When modifying the luteal phase, the pregnancy rate after gonadotropin-releasing hormone agonists triggering is comparable with that of human chorionic gonadotropin triggering human chorionic gonadotropin in in vitro fertilization programs.
Key words: gonadotropin-releasing hormone agonists, human chorionic gonadotropin, assisted reproductive technology, ovarian hyperstimulation syndrome, trigger of ovulation.
2. Kessler MJ, Reddy MS, Shah RH, Bahl OP. Structures of N-glycosidic carbohydrate units of human choronic gonadotropins. J Biochem 1979; 254: 7901–8.
3. Itskovitz J, Boldes R, Levron J et al. Induction of preovulatory luteinizing hormone surge and prevention of ovarian hyperstimulation syndrome by gonadotropin-releasing hormone agonists. Fertil Steril 1991; 56 (2): 213–20.
4. Hoff JD, Quigley ME, Yen SS. Hormonal dynamics at midcycle: a reevaluation. J Clin Endocrinol Metab 1983; 57: 792–6.
5. Fauser BC, Devroey P. Reproductive biology and IVF: ovarian stimulation and luteal consequences. Trends Endocrinol Metab. 2003; 4: 236–42.
6. McElhinney B, Ardill J, Caldwell C et al. Ovarian hyperstimulation syndrome and assisted reproductive technologies: why some and not others? Hum Reprod 2002; 17 (6): 1548–53.
7. Мартазанова Б.А., Вторушина В.В., Ипен С.М. и др. Содержание ангиогенных факторов и интерлейкина-8 в сыворотке крови и фолликулярной жидкости пациенток с высоким риском развития синдрома гиперстимуляции яичников при замене триггера овуляции. Акушерство и гинекология. 2015; 1: 58–65. / Martazanova B.A., Vtorushina V.V., Ipen S.M. i dr. Soderzhanie angiogennykh faktorov i interleikina-8 v syvorotke krovi i follikuliarnoi zhidkosti patsientok s vysokim riskom razvitiia sindroma giperstimuliatsii iaichnikov pri zamene triggera ovuliatsii. Akusherstvo i ginekologiia. 2015; 1: 58–65. [in Russian]
8. Chen SU, Chou CH, Lin CW et al. Signal mechanisms of vascular endothelial growth factor and interleukin-8 in ovarian hyperstimulation syndrome: dopamine targets their common pathways. Hum Reprod 2010; 25 (3): 757–67.
9. Castillo JC, Humaidan P, Bernabeu R. Pharmaceutical options for triggering of final oocyte maturation in ART. BioMed Res Int 2014; article ID 580171.
10. Кулаков В.И., Калинина Е.А., Корнеева И.Е. и др. Лечение синдрома гиперстимуляции яичников, как осложнение программы ЭКО и ПЭ. В кн.: Лечение женского и мужского бесплодия. Вспомогательные репродуктивные технологии в лечении женского и мужского бесплодия. Под ред. В.И.Кулакова. М., 2005. / Kulakov V.I., Kalinina E.A., Korneeva I.E. i dr. Lechenie sindroma giperstimuliatsii iaichnikov, kak oslozhnenie programmy EKO i PE. V kn.: Lechenie zhenskogo i muzhskogo besplodiia. Vspomogatel'nye reproduktivnye tekhnologii v lechenii zhenskogo i muzhskogo besplodiia. Pod red. V.I.Kulakova. M., 2005. [in Russian]
11. Mocanu E., Redmond M L, Hennelly B et al. 2007 Odds of ovarian hyperstimulation syndrome (OHSS)-time for reassessment.Human Fertility 10,175-181.
12. Delvigne A, Rozenberg S. Review of clinical course and treatment of ovarian hyperstimulation syndrome. Human Reproduction Update 2003;9:77–96.
13. Engmann L, DiLuigi A, Schmidt D et al. The use of gonadotropin releasing hormone (GnRH) agonist to induce oocyte maturation after cotreatment with GnRH antagonist in high-risk patients undergoing in vitro fertilization prevents the risk of ovarian hyperstimulation syndrome: a prospective randomized controlled study. Fertil Steril 2008; 89 (1): 84–91. DOI: :10.1016/j.fertnstert.2007.02.002
14. Al-Shawaf T, Grudzinskas JG. Prevention and treatment of ovarian hyperstimulation syndrome. Best Pract Res Clin Obstet Gynecol 2003; 17: 249–61.
15. Mathur RS Akande AV, Keay SD et al. Distinction between early and late ovarian hyperstimulation syndrome. Fertil Steril 2000; 73: 901–7.
16. Корнеева И.Е., Иванова А.В., Баркалина Н.В. Синдром гиперстимуляции яичников: профилактика, диагностика, лечение (обзор литературы). Проблемы репродукции. 2004; 10 (1): 43–50. / Korneeva I.E., Ivanova A.V., Barkalina N.V. Sindrom giperstimuliatsii iaichnikov: profilaktika, diagnostika, lechenie (obzor literatury). Problemy reproduktsii. 2004; 10 (1): 43–50. [in Russian]
17. Назаренко Т.А. Стимуляция функции яичников. М., 2009. / Nazarenko T.A. Stimuliatsiia funktsii iaichnikov. M., 2009. [in Russian]
18. Diedich K, Diedich C, Santos E. Suppression of the endogenous luteinizing hormone surge by the gonadotrophin- releasing hormone antagonist Cetrorelix during controlled ovarian hyperstimulation. Hum Reprod 1994; 9 (5): hh 788–91.
19. Albano C, Smitz J, Camus M et al. Comparison of different doses of gonadotropin-releasing hormone antagonist Cetrorelix during controlled ovarian hyperstimulation. Fertil Steril 1997; 67 (5): 917–22.
20. Gordon K, Williams RF, Danforth DR, Hodgen GD. The combined use of GnRH antagonists with gonadotrophins or pulsatile GnRH in ovulation induction. In: Bouchard P, Caraty A, Coelingh-Bennink HJT, Pavlou SN (eds). GnRH-Analougs, Gonadotrophins and Gonadal Peptides. London: Parthenon Publishing Group, 1993.
21. Gonen Y, Balakier H, Powell W, Casper RF. Use of GnRh agonist to trigger follicular Maturation for in vitro fertilization. J Clin Endocrinol Metab 1990; 71: 918–22.
22. Itskovitz J, Boldes R, Levron J et al. Induction of preovulatory luteinizing hormone surge and prevention of ovarian hyperstimulation syndrome by gonadotropin-releasing hormone agonist. Fertil Steril 1991; 56: 213–20.
23. Hoff JD, Quigley ME, Yen SS. Hormonal dynamics at mid cycle: a reevaluation. J Clin Endocrinol Metab 1983; 57: 792–6.
24. Zelinski-Wooten MB, Hutchinson JS, Hess DL et al. Follicle stimulating hormone alone supports follicle growth and oocyte development in gonadotrophin releasing hormone antagonist-treated monkeys. Hum Reprod 1995; 10: 1658–66.
25. Yding Anderson C, Leonardsen L, Ulloa-Aguirre A et al. FSH-induced resumption of meiosis in mouse oocytes: effect of different isoforms. Mol Hum Reprod 1999; 5: 726–31.
26. Stickland S, Beer WH. Studies on the role of plasminogen activator in ovulation. In vitro response of granulose cells to gonadotropins, cyclic nucleotides and prostaglandins. J Biol Chem 1976; 251: 5694–702.
27. Eppig JJ. FSH stimulates hyaluronic acid synthesis by oocyte-cumuluc cell complexes from mouse preovulatory follicles. Nature 1979; 281: 483–4.
28. Atef A, Francois P, Christian V, Marc-Andre S. The potential role of gap junction communication between cumulus cells and bovine ocytes during in vitro maturation. Mol Reprod Dev 2005; 71 (3): 358–67.
29. Godard NM, Pukazhenthi BS, Wildt DT, Comizzoli P. Paracrine factors from cumulus-enclosed ocytes ensure the successful maturation and fertilization in vitro of denuded oocytes in the cat model. Fertil Steril 2009; 91 (Suppl. 5): 2051–60.
30. Lamb JD, McCulloch C, Jalalian L et al. Follicle stimulating hormone administered at the time of human chorionic gonadotropin trigger improves oocyte developmental competence in in vitro fertilization cycles: a randomized, double-blind, placebo-controlled trial. Fertil Steril 2011; 95: 1655–60.
31. D’Alessandris C, Canipari R, Di Giacomo M et al. Control of mouse cumulus cell-oocyte complex integrity before and after ovulation: plasminogen activator synthesis and matrix degradation. Endocrinology 2001; 142: 3033–40.
32. Oktay K, Turkcuoglu I, Rodriguez-Wallberg KA. GnRH agonist trigger for women with breast cancer undergoing fertility preservation by aromatase inhibitor/FSH stimulation. Reprod Biomed Online 2010; 20: 783–8.
33. Humaidan P, Bredkjaer HE, Bungum L et al. GnRH agonist(buserelin) or HCG for ovulation induction in GnRHnantagonist IVF/ICSI cycles: a prospective randomized study. Hum Reprod 2005; 20: 1213–20.
34. Fauser BC, de Jong D, Olivennes F et al. Endocrine profiles after triggering of final oocyte maturation with GnRH agonist after cotreatment with the GnRH antagonist ganirelix during ovarian hyperstimulation for in vitro fertilization. J Clin Endocrinol Metab 2002; 87: 709–15.
35. Kolibianakis EM, Schultze-Mosgau A, Schroer A et al. A lower ongoing pregnancy rate can be expected when GnRH agonist is used for triggering final oocyte maturation instead of HCG in patients undergoing IVF with GnRH antagonists. Hum Reprod 2005; 20: 2887–92.
36. Galindo A, Bodri D, Jose Guillen J et al. Triggering with HCG or GnRH agonist in GnRH antagonist treated oocyte donation cycles: a randomised clinical trial. Gynecol Endocrinol 2009; 25: 60–6.
37. Melo M, Busso CE, Bellver J et al. GnRH agonist versus recombinant HCG in an oocyte donation programme: a randomized, prospective, controlled, assessorblind study. Reprod Biomed Online 2009; 19: 486–92.
38. Pirard C, Donnez J, Loumaye E. GnRH agonist as luteal phase support in assisted reproduction technique cycles: results of a pilot study. Hum Reprod 2006; 21: 1894–900.
39. Casper RF, Yen SS. Induction of luteolysis in the human with a long-acting analog of luteinizing hormone-releasing factor. Science 1979; 205: 408–10.
40. Sugino N, Kaskida S, Takiguchi S et al. Expression of vascular endothelial growth factor and its receptors in the human corpus luteum during the menstrual cycle and in early pregnancy. J Clin Endocrinol 2000; 85: 3919–24.
41. Wang TH, Horng SG, Chang CL et al. Human chorionic gonadotropin-induced hyperstimulation syndrome is associated with up-regulation of vascular endothelial growth factor. J Clin Endocrinol Metab 2002; 87: 3300–8.
42. Robinson RS, Nicklin LT, Hammond AJ et al. Fibroblast growth factor 2 is more dynamic than vascular endothelial growth factor A during the follicle-luteal transition in the cow. Biol Reprod 2007; 77: 28–36.
43. Berisha B, Steffl M, Amselgruber W, Schams D. Changes in fibroblast growth factor 2 and its receptors in bovine follicles before and after GnRH application and after ovulation. Reproduction 2006; 131: 319–29.
44. Licht P, Russu V, Wildt L. On the role of human chorionic gonadotropin (hCG) in the embryo-endometrial microenvironment: implications for differentiation and implantation. Semin Reprod Med 2001; 19: 37–47.
45. Rao CV. Multiple novel roles of luteinizing hormone. Fertil Steril 2001; 76: 1097–100.
46. Humaidan P. Luteal phase rescue in high-risk OHSS patients by GnRHa triggering in combination with low-dose HCG: a pilot study. Reprod Biomed Online 2009; 18: 630–4.
47. Humaidan P, Ejdrup Bredkjaer H, Westergaard LG, Yding Andersen C. 1500 IU human chorionic gonadotropin administered at oocyte retrieval rescues the luteal phase when gonadotropin-releasing hormone agonist is used for ovulation induction: a prospective, randomized, controlled study. Fertil Steril 2010; 93: 847–54.
48. Shapiro BS, Daneshmand ST, Garner FC et al. Gonadotropin-releasing hormone agonist combined with a reduced dose of human chorionic gonadotropin for final oocyte maturation in fresh autologous cycles of in vitro fertilization. Fertil Steril 2008; 90: 231–3.
49. Yamoto M, Minami S, Nakano R. Immunohistochemical localization of inhibin subunits in human corpora lutea during menstrual cycle and pregnancy. J Clin Endocrinol Metab 1991; 73: 470–7.
50. Treetampinich C, O’Connor AE, MacLachlan V et al. Maternal serum inhibin A concentrations in early pregnancy after IVF and embryo transfer reflect the corpus luteum contribution and pregnancy outcome. Hum Reprod 2000; 15: 2028–32.
51. Muttukrishna S, Child TJ, Groome NP, Ledger WL. Source of circulating levels of inhibin A, pro alpha C-containing inhibins and activin A in early pregnancy. Hum Reprod 1997; 12: 1089–93.
52. Nevo O, Eldar-Geva T, Kol S, Itskovitz-Eldor J. Lower levels of inhibin A and pro-alphaC during the luteal phase after triggering oocyte maturation with a gonadotropin-releasing hormone agonist versus human chorionic gonadotropin. Fertil Steril 2003; 79: 1123–8.
53. Devroey P, Polynoz NP, Blockeel C. An OHSS-Free Clinic by segmentation of IVF treatment. Hum Reprod 2011; 26: 2593–7.
54. Humaidan P, Bungum L, Bungum M, Yding Andersen C. Rescue of corpus luteum function with peri-ovulatory HCG supplementation in IVF/ICSI GnRH antagonist cycles in which ovulation was triggered with a GnRH agonist: a pilot study. Reprod Biomed Online 2006; 13: 173–8.
55. Humaidan P. Luteal phase rescue in high-risk OHSS patients by GnRHa triggering in combination with low-dose HCG: a pilot study. Reprod Biomed Online 2009; 18: 630–4.
56. Humaidan P, Polyzos NP, Alsbjerg B et al. GnRHa trigger and individualized luteal phase hCG support according to ovarian response to stimulation: two prospective randomized controlled multi-centre studies in IVF patients. Hum Reprod 2013; 28 (9): 2511–21.
57. Youssef MA, van der Veen F, Al-Inany HG et al. Gonadotropin-releasing hormone agonist versus HCG for oocyte triggering in antagonist-assisted reproductive technology. Cochrane Database Syst Rev 2014; 10.
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1. Ascoli M, Fanelli F, Segaloff DL. The lutropin/choriogonadotropin receptor, a 2002 perspective. Endor Rev 2002; 23: 141–74.
2. Kessler MJ, Reddy MS, Shah RH, Bahl OP. Structures of N-glycosidic carbohydrate units of human choronic gonadotropins. J Biochem 1979; 254: 7901–8.
3. Itskovitz J, Boldes R, Levron J et al. Induction of preovulatory luteinizing hormone surge and prevention of ovarian hyperstimulation syndrome by gonadotropin-releasing hormone agonists. Fertil Steril 1991; 56 (2): 213–20.
4. Hoff JD, Quigley ME, Yen SS. Hormonal dynamics at midcycle: a reevaluation. J Clin Endocrinol Metab 1983; 57: 792–6.
5. Fauser BC, Devroey P. Reproductive biology and IVF: ovarian stimulation and luteal consequences. Trends Endocrinol Metab. 2003; 4: 236–42.
6. McElhinney B, Ardill J, Caldwell C et al. Ovarian hyperstimulation syndrome and assisted reproductive technologies: why some and not others? Hum Reprod 2002; 17 (6): 1548–53.
7. Martazanova B.A., Vtorushina V.V., Ipen S.M. i dr. Soderzhanie angiogennykh faktorov i interleikina-8 v syvorotke krovi i follikuliarnoi zhidkosti patsientok s vysokim riskom razvitiia sindroma giperstimuliatsii iaichnikov pri zamene triggera ovuliatsii. Akusherstvo i ginekologiia. 2015; 1: 58–65. [in Russian]
8. Chen SU, Chou CH, Lin CW et al. Signal mechanisms of vascular endothelial growth factor and interleukin-8 in ovarian hyperstimulation syndrome: dopamine targets their common pathways. Hum Reprod 2010; 25 (3): 757–67.
9. Castillo JC, Humaidan P, Bernabeu R. Pharmaceutical options for triggering of final oocyte maturation in ART. BioMed Res Int 2014; article ID 580171.
10. Kulakov V.I., Kalinina E.A., Korneeva I.E. i dr. Lechenie sindroma giperstimuliatsii iaichnikov, kak oslozhnenie programmy EKO i PE. V kn.: Lechenie zhenskogo i muzhskogo besplodiia. Vspomogatel'nye reproduktivnye tekhnologii v lechenii zhenskogo i muzhskogo besplodiia. Pod red. V.I.Kulakova. M., 2005. [in Russian]
11. Mocanu E., Redmond M L, Hennelly B et al. 2007 Odds of ovarian hyperstimulation syndrome (OHSS)-time for reassessment.Human Fertility 10,175-181.
12. Delvigne A, Rozenberg S. Review of clinical course and treatment of ovarian hyperstimulation syndrome. Human Reproduction Update 2003;9:77–96.
13. Engmann L, DiLuigi A, Schmidt D et al. The use of gonadotropin releasing hormone (GnRH) agonist to induce oocyte maturation after cotreatment with GnRH antagonist in high-risk patients undergoing in vitro fertilization prevents the risk of ovarian hyperstimulation syndrome: a prospective randomized controlled study. Fertil Steril 2008; 89 (1): 84–91. DOI: :10.1016/j.fertnstert.2007.02.002
14. Al-Shawaf T, Grudzinskas JG. Prevention and treatment of ovarian hyperstimulation syndrome. Best Pract Res Clin Obstet Gynecol 2003; 17: 249–61.
15. Mathur RS Akande AV, Keay SD et al. Distinction between early and late ovarian hyperstimulation syndrome. Fertil Steril 2000; 73: 901–7.
16. Korneeva I.E., Ivanova A.V., Barkalina N.V. Sindrom giperstimuliatsii iaichnikov: profilaktika, diagnostika, lechenie (obzor literatury). Problemy reproduktsii. 2004; 10 (1): 43–50. [in Russian]
17. Nazarenko T.A. Stimuliatsiia funktsii iaichnikov. M., 2009. [in Russian]
18. Diedich K, Diedich C, Santos E. Suppression of the endogenous luteinizing hormone surge by the gonadotrophin- releasing hormone antagonist Cetrorelix during controlled ovarian hyperstimulation. Hum Reprod 1994; 9 (5): hh 788–91.
19. Albano C, Smitz J, Camus M et al. Comparison of different doses of gonadotropin-releasing hormone antagonist Cetrorelix during controlled ovarian hyperstimulation. Fertil Steril 1997; 67 (5): 917–22.
20. Gordon K, Williams RF, Danforth DR, Hodgen GD. The combined use of GnRH antagonists with gonadotrophins or pulsatile GnRH in ovulation induction. In: Bouchard P, Caraty A, Coelingh-Bennink HJT, Pavlou SN (eds). GnRH-Analougs, Gonadotrophins and Gonadal Peptides. London: Parthenon Publishing Group, 1993.
21. Gonen Y, Balakier H, Powell W, Casper RF. Use of GnRh agonist to trigger follicular Maturation for in vitro fertilization. J Clin Endocrinol Metab 1990; 71: 918–22.
22. Itskovitz J, Boldes R, Levron J et al. Induction of preovulatory luteinizing hormone surge and prevention of ovarian hyperstimulation syndrome by gonadotropin-releasing hormone agonist. Fertil Steril 1991; 56: 213–20.
23. Hoff JD, Quigley ME, Yen SS. Hormonal dynamics at mid cycle: a reevaluation. J Clin Endocrinol Metab 1983; 57: 792–6.
24. Zelinski-Wooten MB, Hutchinson JS, Hess DL et al. Follicle stimulating hormone alone supports follicle growth and oocyte development in gonadotrophin releasing hormone antagonist-treated monkeys. Hum Reprod 1995; 10: 1658–66.
25. Yding Anderson C, Leonardsen L, Ulloa-Aguirre A et al. FSH-induced resumption of meiosis in mouse oocytes: effect of different isoforms. Mol Hum Reprod 1999; 5: 726–31.
26. Stickland S, Beer WH. Studies on the role of plasminogen activator in ovulation. In vitro response of granulose cells to gonadotropins, cyclic nucleotides and prostaglandins. J Biol Chem 1976; 251: 5694–702.
27. Eppig JJ. FSH stimulates hyaluronic acid synthesis by oocyte-cumuluc cell complexes from mouse preovulatory follicles. Nature 1979; 281: 483–4.
28. Atef A, Francois P, Christian V, Marc-Andre S. The potential role of gap junction communication between cumulus cells and bovine ocytes during in vitro maturation. Mol Reprod Dev 2005; 71 (3): 358–67.
29. Godard NM, Pukazhenthi BS, Wildt DT, Comizzoli P. Paracrine factors from cumulus-enclosed ocytes ensure the successful maturation and fertilization in vitro of denuded oocytes in the cat model. Fertil Steril 2009; 91 (Suppl. 5): 2051–60.
30. Lamb JD, McCulloch C, Jalalian L et al. Follicle stimulating hormone administered at the time of human chorionic gonadotropin trigger improves oocyte developmental competence in in vitro fertilization cycles: a randomized, double-blind, placebo-controlled trial. Fertil Steril 2011; 95: 1655–60.
31. D’Alessandris C, Canipari R, Di Giacomo M et al. Control of mouse cumulus cell-oocyte complex integrity before and after ovulation: plasminogen activator synthesis and matrix degradation. Endocrinology 2001; 142: 3033–40.
32. Oktay K, Turkcuoglu I, Rodriguez-Wallberg KA. GnRH agonist trigger for women with breast cancer undergoing fertility preservation by aromatase inhibitor/FSH stimulation. Reprod Biomed Online 2010; 20: 783–8.
33. Humaidan P, Bredkjaer HE, Bungum L et al. GnRH agonist(buserelin) or HCG for ovulation induction in GnRHnantagonist IVF/ICSI cycles: a prospective randomized study. Hum Reprod 2005; 20: 1213–20.
34. Fauser BC, de Jong D, Olivennes F et al. Endocrine profiles after triggering of final oocyte maturation with GnRH agonist after cotreatment with the GnRH antagonist ganirelix during ovarian hyperstimulation for in vitro fertilization. J Clin Endocrinol Metab 2002; 87: 709–15.
35. Kolibianakis EM, Schultze-Mosgau A, Schroer A et al. A lower ongoing pregnancy rate can be expected when GnRH agonist is used for triggering final oocyte maturation instead of HCG in patients undergoing IVF with GnRH antagonists. Hum Reprod 2005; 20: 2887–92.
36. Galindo A, Bodri D, Jose Guillen J et al. Triggering with HCG or GnRH agonist in GnRH antagonist treated oocyte donation cycles: a randomised clinical trial. Gynecol Endocrinol 2009; 25: 60–6.
37. Melo M, Busso CE, Bellver J et al. GnRH agonist versus recombinant HCG in an oocyte donation programme: a randomized, prospective, controlled, assessorblind study. Reprod Biomed Online 2009; 19: 486–92.
38. Pirard C, Donnez J, Loumaye E. GnRH agonist as luteal phase support in assisted reproduction technique cycles: results of a pilot study. Hum Reprod 2006; 21: 1894–900.
39. Casper RF, Yen SS. Induction of luteolysis in the human with a long-acting analog of luteinizing hormone-releasing factor. Science 1979; 205: 408–10.
40. Sugino N, Kaskida S, Takiguchi S et al. Expression of vascular endothelial growth factor and its receptors in the human corpus luteum during the menstrual cycle and in early pregnancy. J Clin Endocrinol 2000; 85: 3919–24.
41. Wang TH, Horng SG, Chang CL et al. Human chorionic gonadotropin-induced hyperstimulation syndrome is associated with up-regulation of vascular endothelial growth factor. J Clin Endocrinol Metab 2002; 87: 3300–8.
42. Robinson RS, Nicklin LT, Hammond AJ et al. Fibroblast growth factor 2 is more dynamic than vascular endothelial growth factor A during the follicle-luteal transition in the cow. Biol Reprod 2007; 77: 28–36.
43. Berisha B, Steffl M, Amselgruber W, Schams D. Changes in fibroblast growth factor 2 and its receptors in bovine follicles before and after GnRH application and after ovulation. Reproduction 2006; 131: 319–29.
44. Licht P, Russu V, Wildt L. On the role of human chorionic gonadotropin (hCG) in the embryo-endometrial microenvironment: implications for differentiation and implantation. Semin Reprod Med 2001; 19: 37–47.
45. Rao CV. Multiple novel roles of luteinizing hormone. Fertil Steril 2001; 76: 1097–100.
46. Humaidan P. Luteal phase rescue in high-risk OHSS patients by GnRHa triggering in combination with low-dose HCG: a pilot study. Reprod Biomed Online 2009; 18: 630–4.
47. Humaidan P, Ejdrup Bredkjaer H, Westergaard LG, Yding Andersen C. 1500 IU human chorionic gonadotropin administered at oocyte retrieval rescues the luteal phase when gonadotropin-releasing hormone agonist is used for ovulation induction: a prospective, randomized, controlled study. Fertil Steril 2010; 93: 847–54.
48. Shapiro BS, Daneshmand ST, Garner FC et al. Gonadotropin-releasing hormone agonist combined with a reduced dose of human chorionic gonadotropin for final oocyte maturation in fresh autologous cycles of in vitro fertilization. Fertil Steril 2008; 90: 231–3.
49. Yamoto M, Minami S, Nakano R. Immunohistochemical localization of inhibin subunits in human corpora lutea during menstrual cycle and pregnancy. J Clin Endocrinol Metab 1991; 73: 470–7.
50. Treetampinich C, O’Connor AE, MacLachlan V et al. Maternal serum inhibin A concentrations in early pregnancy after IVF and embryo transfer reflect the corpus luteum contribution and pregnancy outcome. Hum Reprod 2000; 15: 2028–32.
51. Muttukrishna S, Child TJ, Groome NP, Ledger WL. Source of circulating levels of inhibin A, pro alpha C-containing inhibins and activin A in early pregnancy. Hum Reprod 1997; 12: 1089–93.
52. Nevo O, Eldar-Geva T, Kol S, Itskovitz-Eldor J. Lower levels of inhibin A and pro-alphaC during the luteal phase after triggering oocyte maturation with a gonadotropin-releasing hormone agonist versus human chorionic gonadotropin. Fertil Steril 2003; 79: 1123–8.
53. Devroey P, Polynoz NP, Blockeel C. An OHSS-Free Clinic by segmentation of IVF treatment. Hum Reprod 2011; 26: 2593–7.
54. Humaidan P, Bungum L, Bungum M, Yding Andersen C. Rescue of corpus luteum function with peri-ovulatory HCG supplementation in IVF/ICSI GnRH antagonist cycles in which ovulation was triggered with a GnRH agonist: a pilot study. Reprod Biomed Online 2006; 13: 173–8.
55. Humaidan P. Luteal phase rescue in high-risk OHSS patients by GnRHa triggering in combination with low-dose HCG: a pilot study. Reprod Biomed Online 2009; 18: 630–4.
56. Humaidan P, Polyzos NP, Alsbjerg B et al. GnRHa trigger and individualized luteal phase hCG support according to ovarian response to stimulation: two prospective randomized controlled multi-centre studies in IVF patients. Hum Reprod 2013; 28 (9): 2511–21.
57. Youssef MA, van der Veen F, Al-Inany HG et al. Gonadotropin-releasing hormone agonist versus HCG for oocyte triggering in antagonist-assisted reproductive technology. Cochrane Database Syst Rev 2014; 10.
1. ГБОУ ВПО Первый Московский государственный медицинский университет им. И.М.Сеченова Минздрава России. 119991, Россия, Москва, ул. Трубецкая, д. 8, стр. 2;
2. ФГБУ Научный центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова Минздрава России. 117997, Россия, Москва, ул. Академика Опарина, д. 4
*dr.snehaeapen@gmail.com
________________________________________________
S.M.Eapen*1, N.G.Mishiyeva2, B.A.Martazanova2, T.V.Dontsova2, S.V.Pavlovich1,2
1. I.M.Sechenov First Moscow State Medical University. 119991, Russian Federation, Moscow, ul. Trubetskaia, d. 8, str. 2;
2. V.I.Kulakov Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Akademika Oparina, d. 4
*dr.snehaeapen@gmail.com