Роль вспомогательного хетчинга в программах лечения бесплодия методами вспомогательных репродуктивных технологий: обзор литературы
Роль вспомогательного хетчинга в программах лечения бесплодия методами вспомогательных репродуктивных технологий: обзор литературы
Ибрагимова Э.О., Долгушина Н.В., Сыркашева А.Г. и др. Роль вспомогательного хетчинга в программах лечения бесплодия методами вспомогательных репродуктивных технологий: обзор литературы. Гинекология. 2016; 18 (3): 44–47.
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Ibragimova E.O., Dolgushina N.V., Syrkasheva A.G. et al. The role of assisted hatching in in vitro fertilization cycles: a literature review. Gynecology. 2016; 18 (3): 44–47.
Роль вспомогательного хетчинга в программах лечения бесплодия методами вспомогательных репродуктивных технологий: обзор литературы
Ибрагимова Э.О., Долгушина Н.В., Сыркашева А.Г. и др. Роль вспомогательного хетчинга в программах лечения бесплодия методами вспомогательных репродуктивных технологий: обзор литературы. Гинекология. 2016; 18 (3): 44–47.
________________________________________________
Ibragimova E.O., Dolgushina N.V., Syrkasheva A.G. et al. The role of assisted hatching in in vitro fertilization cycles: a literature review. Gynecology. 2016; 18 (3): 44–47.
Цель исследования – провести систематический анализ данных, имеющихся в современной литературе, о роли и эффективности вспомогательного хетчинга в программах лечения бесплодия методами вспомогательных репродуктивных технологий (ВРТ). Материалы и методы. В обзор включены данные зарубежных и отечественных статей, найденных в PubМed по данной теме, опубликованных за последние 10 лет. Результаты. Описаны возможные механизмы действия и эффективность вспомогательного хетчинга в процессе имплантации эмбриона, а также возможные факторы, влияющие на эффективность самостоятельного хетчинга. Заключение. Необходимо проведение дальнейших исследований по изучению влияния разных видов вспомогательного хетчинга на наступление клинической беременности, рождение здорового ребенка и развитие многоплодных беременностей в программах ВРТ. Ключевые слова: бесплодие, вспомогательный хетчинг, экстракорпоральное оплодотворение, зона пеллюцида, имплантация эмбриона.
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Objective: systematic review to determine the role of assisted hatching in the IVF cycles. Materials and methods. We searched the MEDLINE base (2005 to February 2016) and included all articles related to the question. Results. Possible mechanisms and efficiency of assisted hatching in embryo implantation are described below as well as possible factors that influence the efficiency of spontaneous hatching. Conclusions. The included trials provided insufficient data to investigate the role of different types of the assisted hatching in clinical pregnancy rate, live birth rate and development of multiple gestations. Key words: infertility, assisted hatching, in vitro fertilization, zona pellucida, embryo implantation.
1. Gunby J, Daya S. Assisted reproductive technologies (ART) in Canada: 2002 results from the Canadian ART Register. Fertil Steril 2006; 86 (5): 1356–64. doi:10.1016/j.fertnstert.2006.04.030.
2. Bissonnette F, Cohen J, Collins J et al. Incidence and complications of multiple gestation in Canada: proceedings of an expert meeting. Reprod Biomed Online 2007; 14 (6): 773–90. doi:10.1016/S1472-6483(10)60681-5.
3. Кузьмичев Л.Н., Смольникова В.Ю., Калинина Е.А., Дюжева Е.В. Принципы комплексной оценки и подготовки эндометрия у пациенток программ вспомогательных репродуктивных технологий. Акушерство и гинекология. 2010; 5: 32–6. / Kuz'michev L.N., Smol'nikova V.Iu., Kalinina E.A., Diuzheva E.V. Printsipy kompleksnoi otsenki i podgotovki endometriia u patsientok programm vspomogatel'nykh reproduktivnykh tekhnologii. Akusherstvo i ginekologiia. 2010; 5: 32–6. [in Russian]
4. Carney SK, Das S, Blake D et al. Assisted hatching on assisted conception (in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI). Cochrane Database Syst Rev 2012; 12. doi:10.1002/14651858.CD001894.pub5.
5. Germond M, Primi MP, Senn A. Hatching: how to sel ect the clinical indications. Ann N Y Acad Sci 2004; 1034: 145–51. doi:10.1196/annals.1335.017.
6. Sathananthan H, Gunasheela S, Menezes J. Critical evaluation of human blastocysts for assisted reproduction techniques and embryonic stem cell biotechnology. Reprod Biomed Online 2003; 7 (2): 219–27. doi:10.1016/S1472-6483(10)61756-7.
7. DeMeestere I, Barlow P, Leroy F. Hardening of zona pellucida of mouse oocytes and embryos in vivo and in vitro. Int J Fertil Womens Med 1997; 42: 219–22.
8. Carroll J, Depypere H, Matthews CD. Freeze-thaw-induced changes of the zona pellucida explains decreased rates of fertilization in frozen-thawed mouse oocytes. J Reprod Fertil 1990; 90 (2): 547–53. doi:10.1530/jrf.0.0900547.
9. Lefièvre L, Conner S, Salpekar A et al. Four zona pellucida glycoproteins are expressed in the human. Hum Reprod 2004; 19 (7): 1580–6. doi:10.1093/humrep/deh301.
10. Conner SJ, Lefièvre L, Hughes DC, Barratt CLR. Cracking the egg: Increased complexity in the zona pellucida. Hum Reprod 2005; 20 (5): 1148–52. doi:10.1093/humrep/deh835.
11. Chakravarty S, Kadunganattil S, Bansal P et al. Relevance of glycosylation of human zona pellucida glycoproteins for their binding to capacitated human spermatozoa and subsequent induction of acrosomal exocytosis. Mol Reprod Dev 2008; 75 (1): 75–88. doi:10.1002/mrd.20726.
12. Chiu PC, Wong BS, Chung MK et al. Effects of native human zona pellucida glycoproteins 3 and 4 on acrosome reaction and zona pellucida binding of human spermatozoa. Biol Reprod 2008; 79 (5): 869–77. doi:10.1095/biolreprod.108.069344.
13. Gupta SK, Bansal P, Ganguly A et al. Human zona pellucida glycoproteins: functional relevance during fertilization. J Reprod Immunol 2009; 83 (1–2): 50–5. doi:10.1016/j.jri.2009.07.008.
14. Rankin T, Talbot P, Lee E, Dean J. Abnormal zonae pellucidae in mice lacking ZP1 result in early embryonic loss. Development 1999; 126 (17): 3847–55.
15. Rankin TL, O’Brien M, Lee E et al. Defective zonae pellucidae in Zp2-null mice disrupt folliculogenesis, fertility and development. Development 2001; 128 (7): 1119–26.
16. Rankin TL, Familari M, Lee E et al. Mice homozygous for an insertional mutation in the Zp3 gene lack a zona pellucida and are infertile. Development 1996; 122 (9): 2903–10.
17. Pokkyla RM, Lakkakorpi JT, Nuojua-Huttunen SH, Tapanainen JS. Sequence variations in human ZP genes as potential modifiers of zona pellucida architecture. Fertil Steril 2011; 95 (8): 2669–72. doi:10.1016/j.fertnstert.2011.01.168.
18. Adjaye J, Huntriss J, Herwig R et al. Primary differentiation in the human blastocyst: comparative molecular portraits of inner cell mass and trophectoderm cells. Stem Cells 2005; 23 (10): 1514–25. doi:10.1634/stemcells.2005-0113.
19. Martins WP, Rocha IA, Ferriani RA, Nastri CO. Assisted hatching of human embryos: A systematic review and meta-analysis of randomized controlled trials. Hum Reprod Update 2011; 17 (4): 438–53. doi:10.1093/humupd/dmr012.
20. Cohen J, Alikani M, Trowbridge J, Rosenwaks Z. Implantation enhancement by selective assisted hatching using zona drilling of human embryos with poor prognosis. Hum Reprod 1992; 7 (5): 685–91.
21. Hammadeh ME, Fischer-Hammadeh C, Ali KR. Assisted hatching in assisted reproduction: a state of the art. J Assist Reprod Genet. 2011; 28 (2): 119–28. doi:10.1007/s10815-010-9495-3.
22. Stein A, Rufas O, Amit S et al. Assisted hatching by partial zona dissection of human pre-embryos in patients with recurrent implantation failure after in vitro fertilization. Fertil Steril 1995; 63 (4): 838–41.
23. Das S, Blake D, Farquhar C, Seif MM. Assisted hatching on assisted conception (IVF and ICSI). Cochrane Database Syst Rev 2009; 2. doi:10.1002/14651858.CD001894.pub4.
24. Cohen J, Elsner C, Kort H et al. Impairment of the hatching process following IVF in the human and improvement of implantation by assisting hatching using micromanipulation. Hum Reprod 1990; 5 (1): 7–13.
25. Tadir Y, Douglas-Hamilton DH. Laser effects in the manipulation of human eggs and embryos for in vitro fertilization. Methods Cell Biol 2007; 82 (6): 409–31. doi:10.1016/S0091-679X(06)82014-5.
26. Nakayama T, Fujiwara H, Tastumi K et al. A new assisted hatching technique using a piezo-micromanipulator. Fertil Steril 1998; 69 (4): 784–8. doi:10.1016/S0015-0282(98)00017-X.
27. Nakayama T, Fujiwara H, Yamada S et al. Clinical application of a new assisted hatching method using a piezo- micromanipulator for morphologically low-quality embryos in poor-prognosis infertile patients. Fertil Steril 1999; 71 (6): 1014–8. doi:10.1016/S0015-0282(99)00131-4.
28. Feng HL, Hershlag A, Scholl GM, Cohen MA. A retroprospective study comparing three different assisted hatching techniques. Fertil Steril 2009; 91 (4 Suppl.): 1323–5. doi:10.1016/j.fertnstert.2008.02.133.
29. Balaban B, Urman B, Alatas C et al. A comparison of four different techniques of assisted hatching. Hum Reprod 2002; 17 (5): 1239–43. doi:10.1093/humrep/17.5.1239.
30. Fong CY, Bongso A, Sathananthan H, Ho J, Ng SC. Ultrastructural observations of enzymatically treated human blastocysts: zona-free blastocyst transfer and rescue of blastocysts with hatching difficulties. Hum Reprod 2001; 16 (3): 540–6.
31. Hershlag A, Paine T, Cooper GW et al. Monozygotic twinning associated with mechanical assisted hatching. Fertil Steril 1999; 71 (1): 144–6. doi:10.1016/S0015-0282(98)00402-6.
32. Schieve LA, Meikle SF, Peterson HB et al. Does assisted hatching pose a risk for monozygotic twinning in pregnancies conceived through in vitro fertilization? Fertil Steril 2000; 74 (2): 288–94. doi:10.1016/S0015-0282(00)00602-6.
33. Cohen J. Assisted hatching of human embryos. J Vitr Fert Embryo Transf 1991; 8 (4): 179–90. doi:10.1007/bf01130802.
34. Vitthala S, Gelbaya TA, Brison DR et al. The risk of monozygotic twins after assisted reproductive technology: a systematic review and meta-analysis. Hum Reprod Update 2009; 15 (1): 45–55. doi:10.1093/humupd/dmn045.
35. Alikani M, Noyes N, Cohen J, Rosenwaks Z. Monozygotic twinning in the human is associated with the zona pellucida architecture. Hum Reprod 1994; 9 (7): 1318–21.
36. Dale B, Gualtieri R, Talevi R et al. Intercellular communication in the early human embryo. Mol Reprod Dev 1991; 29 (1): 22–8. doi:10.1002/mrd.1080290105.
37. Yanaihara A, Yorimitsu T, Motoyama H et al. Monozygotic multiple gestation following in vitro fertilization: Analysis of seven cases fr om Japan. J Exp Clin Assist Reprod 2007; 4: 2–5. doi:10.1186/1743-1050-4-4.
38. Elizur SE, Levron J, Shrim A et al. Monozygotic twinning is not associated with zona pellucida micromanipulation procedures but increases with high-order multiple pregnancies. Fertil Steril. 2004; 82 (2): 500–1. doi:10.1016/j.fertnstert.2004.02.106.
39. Knopman J, Krey LC, Lee J et al. Monozygotic twinning: an eight-year experience at a large IVF center. Fertil Steril 2010; 94 (2): 502–10. doi:10.1016/j.fertnstert.2009.03.064.
________________________________________________
1. Gunby J, Daya S. Assisted reproductive technologies (ART) in Canada: 2002 results from the Canadian ART Register. Fertil Steril 2006; 86 (5): 1356–64. doi:10.1016/j.fertnstert.2006.04.030.
2. Bissonnette F, Cohen J, Collins J et al. Incidence and complications of multiple gestation in Canada: proceedings of an expert meeting. Reprod Biomed Online 2007; 14 (6): 773–90. doi:10.1016/S1472-6483(10)60681-5.
3. Kuz'michev L.N., Smol'nikova V.Iu., Kalinina E.A., Diuzheva E.V. Printsipy kompleksnoi otsenki i podgotovki endometriia u patsientok programm vspomogatel'nykh reproduktivnykh tekhnologii. Akusherstvo i ginekologiia. 2010; 5: 32–6. [in Russian]
4. Carney SK, Das S, Blake D et al. Assisted hatching on assisted conception (in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI). Cochrane Database Syst Rev 2012; 12. doi:10.1002/14651858.CD001894.pub5.
5. Germond M, Primi MP, Senn A. Hatching: how to sel ect the clinical indications. Ann N Y Acad Sci 2004; 1034: 145–51. doi:10.1196/annals.1335.017.
6. Sathananthan H, Gunasheela S, Menezes J. Critical evaluation of human blastocysts for assisted reproduction techniques and embryonic stem cell biotechnology. Reprod Biomed Online 2003; 7 (2): 219–27. doi:10.1016/S1472-6483(10)61756-7.
7. DeMeestere I, Barlow P, Leroy F. Hardening of zona pellucida of mouse oocytes and embryos in vivo and in vitro. Int J Fertil Womens Med 1997; 42: 219–22.
8. Carroll J, Depypere H, Matthews CD. Freeze-thaw-induced changes of the zona pellucida explains decreased rates of fertilization in frozen-thawed mouse oocytes. J Reprod Fertil 1990; 90 (2): 547–53. doi:10.1530/jrf.0.0900547.
9. Lefièvre L, Conner S, Salpekar A et al. Four zona pellucida glycoproteins are expressed in the human. Hum Reprod 2004; 19 (7): 1580–6. doi:10.1093/humrep/deh301.
10. Conner SJ, Lefièvre L, Hughes DC, Barratt CLR. Cracking the egg: Increased complexity in the zona pellucida. Hum Reprod 2005; 20 (5): 1148–52. doi:10.1093/humrep/deh835.
11. Chakravarty S, Kadunganattil S, Bansal P et al. Relevance of glycosylation of human zona pellucida glycoproteins for their binding to capacitated human spermatozoa and subsequent induction of acrosomal exocytosis. Mol Reprod Dev 2008; 75 (1): 75–88. doi:10.1002/mrd.20726.
12. Chiu PC, Wong BS, Chung MK et al. Effects of native human zona pellucida glycoproteins 3 and 4 on acrosome reaction and zona pellucida binding of human spermatozoa. Biol Reprod 2008; 79 (5): 869–77. doi:10.1095/biolreprod.108.069344.
13. Gupta SK, Bansal P, Ganguly A et al. Human zona pellucida glycoproteins: functional relevance during fertilization. J Reprod Immunol 2009; 83 (1–2): 50–5. doi:10.1016/j.jri.2009.07.008.
14. Rankin T, Talbot P, Lee E, Dean J. Abnormal zonae pellucidae in mice lacking ZP1 result in early embryonic loss. Development 1999; 126 (17): 3847–55.
15. Rankin TL, O’Brien M, Lee E et al. Defective zonae pellucidae in Zp2-null mice disrupt folliculogenesis, fertility and development. Development 2001; 128 (7): 1119–26.
16. Rankin TL, Familari M, Lee E et al. Mice homozygous for an insertional mutation in the Zp3 gene lack a zona pellucida and are infertile. Development 1996; 122 (9): 2903–10.
17. Pokkyla RM, Lakkakorpi JT, Nuojua-Huttunen SH, Tapanainen JS. Sequence variations in human ZP genes as potential modifiers of zona pellucida architecture. Fertil Steril 2011; 95 (8): 2669–72. doi:10.1016/j.fertnstert.2011.01.168.
18. Adjaye J, Huntriss J, Herwig R et al. Primary differentiation in the human blastocyst: comparative molecular portraits of inner cell mass and trophectoderm cells. Stem Cells 2005; 23 (10): 1514–25. doi:10.1634/stemcells.2005-0113.
19. Martins WP, Rocha IA, Ferriani RA, Nastri CO. Assisted hatching of human embryos: A systematic review and meta-analysis of randomized controlled trials. Hum Reprod Update 2011; 17 (4): 438–53. doi:10.1093/humupd/dmr012.
20. Cohen J, Alikani M, Trowbridge J, Rosenwaks Z. Implantation enhancement by selective assisted hatching using zona drilling of human embryos with poor prognosis. Hum Reprod 1992; 7 (5): 685–91.
21. Hammadeh ME, Fischer-Hammadeh C, Ali KR. Assisted hatching in assisted reproduction: a state of the art. J Assist Reprod Genet. 2011; 28 (2): 119–28. doi:10.1007/s10815-010-9495-3.
22. Stein A, Rufas O, Amit S et al. Assisted hatching by partial zona dissection of human pre-embryos in patients with recurrent implantation failure after in vitro fertilization. Fertil Steril 1995; 63 (4): 838–41.
23. Das S, Blake D, Farquhar C, Seif MM. Assisted hatching on assisted conception (IVF and ICSI). Cochrane Database Syst Rev 2009; 2. doi:10.1002/14651858.CD001894.pub4.
24. Cohen J, Elsner C, Kort H et al. Impairment of the hatching process following IVF in the human and improvement of implantation by assisting hatching using micromanipulation. Hum Reprod 1990; 5 (1): 7–13.
25. Tadir Y, Douglas-Hamilton DH. Laser effects in the manipulation of human eggs and embryos for in vitro fertilization. Methods Cell Biol 2007; 82 (6): 409–31. doi:10.1016/S0091-679X(06)82014-5.
26. Nakayama T, Fujiwara H, Tastumi K et al. A new assisted hatching technique using a piezo-micromanipulator. Fertil Steril 1998; 69 (4): 784–8. doi:10.1016/S0015-0282(98)00017-X.
27. Nakayama T, Fujiwara H, Yamada S et al. Clinical application of a new assisted hatching method using a piezo- micromanipulator for morphologically low-quality embryos in poor-prognosis infertile patients. Fertil Steril 1999; 71 (6): 1014–8. doi:10.1016/S0015-0282(99)00131-4.
28. Feng HL, Hershlag A, Scholl GM, Cohen MA. A retroprospective study comparing three different assisted hatching techniques. Fertil Steril 2009; 91 (4 Suppl.): 1323–5. doi:10.1016/j.fertnstert.2008.02.133.
29. Balaban B, Urman B, Alatas C et al. A comparison of four different techniques of assisted hatching. Hum Reprod 2002; 17 (5): 1239–43. doi:10.1093/humrep/17.5.1239.
30. Fong CY, Bongso A, Sathananthan H, Ho J, Ng SC. Ultrastructural observations of enzymatically treated human blastocysts: zona-free blastocyst transfer and rescue of blastocysts with hatching difficulties. Hum Reprod 2001; 16 (3): 540–6.
31. Hershlag A, Paine T, Cooper GW et al. Monozygotic twinning associated with mechanical assisted hatching. Fertil Steril 1999; 71 (1): 144–6. doi:10.1016/S0015-0282(98)00402-6.
32. Schieve LA, Meikle SF, Peterson HB et al. Does assisted hatching pose a risk for monozygotic twinning in pregnancies conceived through in vitro fertilization? Fertil Steril 2000; 74 (2): 288–94. doi:10.1016/S0015-0282(00)00602-6.
33. Cohen J. Assisted hatching of human embryos. J Vitr Fert Embryo Transf 1991; 8 (4): 179–90. doi:10.1007/bf01130802.
34. Vitthala S, Gelbaya TA, Brison DR et al. The risk of monozygotic twins after assisted reproductive technology: a systematic review and meta-analysis. Hum Reprod Update 2009; 15 (1): 45–55. doi:10.1093/humupd/dmn045.
35. Alikani M, Noyes N, Cohen J, Rosenwaks Z. Monozygotic twinning in the human is associated with the zona pellucida architecture. Hum Reprod 1994; 9 (7): 1318–21.
36. Dale B, Gualtieri R, Talevi R et al. Intercellular communication in the early human embryo. Mol Reprod Dev 1991; 29 (1): 22–8. doi:10.1002/mrd.1080290105.
37. Yanaihara A, Yorimitsu T, Motoyama H et al. Monozygotic multiple gestation following in vitro fertilization: Analysis of seven cases fr om Japan. J Exp Clin Assist Reprod 2007; 4: 2–5. doi:10.1186/1743-1050-4-4.
38. Elizur SE, Levron J, Shrim A et al. Monozygotic twinning is not associated with zona pellucida micromanipulation procedures but increases with high-order multiple pregnancies. Fertil Steril. 2004; 82 (2): 500–1. doi:10.1016/j.fertnstert.2004.02.106.
39. Knopman J, Krey LC, Lee J et al. Monozygotic twinning: an eight-year experience at a large IVF center. Fertil Steril 2010; 94 (2): 502–10. doi:10.1016/j.fertnstert.2009.03.064.
1. ФГБУ Научный центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова Минздрава России. 117997, Россия, Москва, ул. Академика Опарина, д. 4;
2. ФГБОУ ВО Московский государственный университет им. М.В.Ломоносова. 119192, Россия, Москва, Ломоносовский пр., д. 31, корп. 5;
3. ГБОУ ВПО Московский государственный медико-стоматологический университет им. А.И.Евдокимова Минздрава России. 127473, Россия, Москва, ул. Делегатская, д. 20, стр. 1
*espet2007@yandex.ru
1. V.I.Kulakov Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation. 117997, Russian
Federation, Moscow, ul. Akademika Oparina, d. 4;
2. M.V.Lomonosov Moscow State University. 119192, Russian Federation, Moscow, Lomonosovskii pr., d. 31, korp. 5;
3. A.I.Evdokimov Moscow State Medical and Dental University of the Ministry of Health of the Russian Federation. 127473, Russian Federation, Moscow, ul. Delegatskaia, d. 20, str. 1
*espet2007@yandex.ru