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Роли витамина D в профилактике и лечении женского бесплодия
Роли витамина D в профилактике и лечении женского бесплодия
Громова О.А., Торшин И.Ю., Джиджихия Л.К., Гоголева И.В. Роли витамина D в профилактике и лечении женского бесплодия. Гинекология. 2016; 18 (3): 34–39.
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Аннотация
Витамин D является неотъемлемым компонентом поддержки репродуктивного здоровья женщины, так как участвует в регулировании овуляции, функций эндометрия и яичников, поддерживает высокую чувствительность этих тканей к половым гормонам. Результаты фундаментальных и клинических исследований демонстрируют эффективность использования витамина D при его дефиците для нормализации репродуктивной функции у женщин.
Ключевые слова: бесплодие, витамин D, лечение.
Key words: infertility, vitamin D, treatment.
Ключевые слова: бесплодие, витамин D, лечение.
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Key words: infertility, vitamin D, treatment.
Полный текст
Список литературы
1. Доклад о репродуктивном здоровье. Всемирная организация здравоохранения, Европейское региональное бюро, 2011. / Doklad o reproduktivnom zdorov'e. Vsemirnaia organizatsiia zdravookhraneniia, Evropeiskoe regional'noe biuro, 2011. [in Russian]
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3. Громова О.А., Торшин И.Ю. Витамин D – смена парадигмы. М.: Торус Пресс, 2015. / Gromova O.A., Torshin I.Iu. Vitamin D – smena paradigmy. M.: Torus Press, 2015. [in Russian]
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5. Shahrokhi SZ et al. Role of vitamin D in female Reproduction. Clin Chim Acta 2016; 455: 33–8.
6. Dressler N et al. BMI and season are associated with vitamin D deficiency in women with impaired fertility: a two-centre analysis. Arch Gynecol Obstet 2016; 293 (4): 907–14.
7. Pagliardini L et al. High Prevalence of Vitamin D Deficiency in Infertile Women Referring for Assisted Reproduction. Nutrients 2015; 7 (12): 9972–84.
8. Dicken CL et al. Peripubertal vitamin D(3) deficiency delays puberty and disrupts the estrous cycle in adult female mice. Biol Reprod 2012; 87 (2): 51.
9. Irani M, Merhi Z. Role of vitamin D in ovarian physiology and its implication in reproduction: a systematic review. Fertil Steril 2014; 102 (2): 460–8.
10. Merhi Z et al. Vitamin D alters genes involved in follicular development and steroidogenesis in human cumulus granulosa cells. J Clin Endocrinol Metab 2014; 99 (6): E1137–45; doi: 10.1210/jc.2013-4161
11. Fox C et al. Local and systemic factors and implantation: what is the evidence? Fertil Steril 2016; Fertil Steril: S0015–0282(16)0013.
12. Rudick BJ. Characterizing the influence of vitamin D levels on IVF outcomes et al. Fertil Steril 2014; 101 (2).
13. Sebiha Ozkan et al. Replete vitamin D stores predict reproductive success following IVF. Fertil Steril 2010; 94 (4): 1314–9; doi:10.1016
14. Nikolaos P Polyzos et al. Vitamin D deficiency and pregnancy rates in women undergoing single embryo, blastocyst stage, transfer (SET) for IVF/ICSI. Hum Reprod 2014; 29 (9): 2032–40.
15. Laya Farzadi et al. Correlation between follicular fluid 25-OH vitamin D and assisted reproductive outcomes. Iran J Reprod Med 2015; 13(6): 361–6.
16. Lerchbaum E et al. Vitamin D and female fertility. Cur Opin Obstet Gynecol 2014; 26 (3): 145–50.
17. Abdullah UH et al. Vitamin D and assisted reproduction technologies: current concepts Association of Vitamin D with outcome after intra cytoplasmic sperm injection. J Matern Fetal Neonatal Med 2016; p. 1–16.
18. Vanni et al. Vitamin D and assisted reproduction technologies: current oncepts. Reprod Biol Endocrinol 2014; 12: 47.
19. Patra SK et al. Vitamin D as a predictor of insulin resistance in polycystic ovarian syndrome. Diabetes Metab Syndr 2012; 6 (3): 146–9.
20. Guducu N et al. 25-Hydroxyvitamin D levels are related to hyperinsulinemia in polycystic ovary syndrome. Gynecol Endocrinol 2014; 30 (8): 557–60.
21. Ngo DT et al. Determinants of insulin responsiveness in young women: Impact of polycystic ovarian syndrome, nitric oxide, and vitamin D. Nitric Oxide 2011; 25 (3): 326–30.
22. Jia XZ et al. Effect of vitamin D on clinical and biochemical parameters in polycystic ovary syndrome women: A meta-analysis. J Obstet Gynaecol Res 2015; 41 (11): 1791–802.
23. He C et al. Serum Vitamin D Levels and Polycystic Ovary syndrome: A Systematic Review and Meta-Analysis. Nutrients 2015; 7 (6): 4555–77.
24. Irani M et al. Vitamin D increases serum levels of the soluble receptor for advanced glycation end products in women with PCOS. J Clin Endocrinol Metab 2014; 99 (5): E886–90.
25. Irani M et al. Vitamin D Supplementation Decreases TGF-beta1 Bioavailability in PCOS: A Randomized Placebo-Controlled Trial. J Clin Endocrinol Metab 2015; 100 (11): 4307–14.
26. Garbedian K et al. Effect of vitamin D status on clinical pregnancy rates following in vitro fertilization. CMAJ Open 2013; doi:10.9778/cmajo.20120032
27. Panagiotis Anagnostis et al. Vitamin D in human reproduction: a narrative review. Int J Clin Pract 2013; 67 (3): 225–35; doi: 10.1111/ijcp.12031
28. Paffoni A et al. Vitamin D deficiency and infertility: insights from in vitro fertilization cycles. J Clin Endocrinol Metab 2014 Nov 99 (11): E2372-6. doi: 10.1210/jc.2014-1802.
29. Rudick BJ et al. Influence of vitamin D levels on in vitro fertilization outcomes in donor-recipient cycles. Fertil Steril 2014; 101 (2): 447–52.
30. Ozkan S et al. Replete vitamin D stores predict reproductive success following in vitro fertilization. Fertil Steril 2010; 94 (4): 1314–9.
31. Lv SS et al. Serum vitamin D status and in vitro fertilization outcomes: a systematic review and meta-analysis. Arch Gynecol Obstet 2016; 293 (6): 1339–45; doi: 10.1007/s00404-016-4058-1
32. Holick MF. Evaluation, treatment and Prevention of Vitamin D deficiency: an Endocrine society clinical practice guideline. J Clin Metab 2011; 9: 1911–30.
2. Laura Buggio MD et al. Vitamin D and benign gynaecological diseases: A critical analysis of the current evidence, Gynecological Endocrinology; doi: 10.3109/09513590.2015.1111329
3. Gromova O.A., Torshin I.Iu. Vitamin D – smena paradigmy. M.: Torus Press, 2015. [in Russian]
4. Lerchbaum E, Obermayer-Pietsch B. Vitamin D and fertility: a systematic review. Eur J Endocrinol 2012; 166 (5): 765–78.
5. Shahrokhi SZ et al. Role of vitamin D in female Reproduction. Clin Chim Acta 2016; 455: 33–8.
6. Dressler N et al. BMI and season are associated with vitamin D deficiency in women with impaired fertility: a two-centre analysis. Arch Gynecol Obstet 2016; 293 (4): 907–14.
7. Pagliardini L et al. High Prevalence of Vitamin D Deficiency in Infertile Women Referring for Assisted Reproduction. Nutrients 2015; 7 (12): 9972–84.
8. Dicken CL et al. Peripubertal vitamin D(3) deficiency delays puberty and disrupts the estrous cycle in adult female mice. Biol Reprod 2012; 87 (2): 51.
9. Irani M, Merhi Z. Role of vitamin D in ovarian physiology and its implication in reproduction: a systematic review. Fertil Steril 2014; 102 (2): 460–8.
10. Merhi Z et al. Vitamin D alters genes involved in follicular development and steroidogenesis in human cumulus granulosa cells. J Clin Endocrinol Metab 2014; 99 (6): E1137–45; doi: 10.1210/jc.2013-4161
11. Fox C et al. Local and systemic factors and implantation: what is the evidence? Fertil Steril 2016; Fertil Steril: S0015–0282(16)0013.
12. Rudick BJ. Characterizing the influence of vitamin D levels on IVF outcomes et al. Fertil Steril 2014; 101 (2).
13. Sebiha Ozkan et al. Replete vitamin D stores predict reproductive success following IVF. Fertil Steril 2010; 94 (4): 1314–9; doi:10.1016
14. Nikolaos P Polyzos et al. Vitamin D deficiency and pregnancy rates in women undergoing single embryo, blastocyst stage, transfer (SET) for IVF/ICSI. Hum Reprod 2014; 29 (9): 2032–40.
15. Laya Farzadi et al. Correlation between follicular fluid 25-OH vitamin D and assisted reproductive outcomes. Iran J Reprod Med 2015; 13(6): 361–6.
16. Lerchbaum E et al. Vitamin D and female fertility. Cur Opin Obstet Gynecol 2014; 26 (3): 145–50.
17. Abdullah UH et al. Vitamin D and assisted reproduction technologies: current concepts Association of Vitamin D with outcome after intra cytoplasmic sperm injection. J Matern Fetal Neonatal Med 2016; p. 1–16.
18. Vanni et al. Vitamin D and assisted reproduction technologies: current oncepts. Reprod Biol Endocrinol 2014; 12: 47.
19. Patra SK et al. Vitamin D as a predictor of insulin resistance in polycystic ovarian syndrome. Diabetes Metab Syndr 2012; 6 (3): 146–9.
20. Guducu N et al. 25-Hydroxyvitamin D levels are related to hyperinsulinemia in polycystic ovary syndrome. Gynecol Endocrinol 2014; 30 (8): 557–60.
21. Ngo DT et al. Determinants of insulin responsiveness in young women: Impact of polycystic ovarian syndrome, nitric oxide, and vitamin D. Nitric Oxide 2011; 25 (3): 326–30.
22. Jia XZ et al. Effect of vitamin D on clinical and biochemical parameters in polycystic ovary syndrome women: A meta-analysis. J Obstet Gynaecol Res 2015; 41 (11): 1791–802.
23. He C et al. Serum Vitamin D Levels and Polycystic Ovary syndrome: A Systematic Review and Meta-Analysis. Nutrients 2015; 7 (6): 4555–77.
24. Irani M et al. Vitamin D increases serum levels of the soluble receptor for advanced glycation end products in women with PCOS. J Clin Endocrinol Metab 2014; 99 (5): E886–90.
25. Irani M et al. Vitamin D Supplementation Decreases TGF-beta1 Bioavailability in PCOS: A Randomized Placebo-Controlled Trial. J Clin Endocrinol Metab 2015; 100 (11): 4307–14.
26. Garbedian K et al. Effect of vitamin D status on clinical pregnancy rates following in vitro fertilization. CMAJ Open 2013; doi:10.9778/cmajo.20120032
27. Panagiotis Anagnostis et al. Vitamin D in human reproduction: a narrative review. Int J Clin Pract 2013; 67 (3): 225–35; doi: 10.1111/ijcp.12031
28. Paffoni A et al. Vitamin D deficiency and infertility: insights from in vitro fertilization cycles. J Clin Endocrinol Metab 2014 Nov 99 (11): E2372-6. doi: 10.1210/jc.2014-1802.
29. Rudick BJ et al. Influence of vitamin D levels on in vitro fertilization outcomes in donor-recipient cycles. Fertil Steril 2014; 101 (2): 447–52.
30. Ozkan S et al. Replete vitamin D stores predict reproductive success following in vitro fertilization. Fertil Steril 2010; 94 (4): 1314–9.
31. Lv SS et al. Serum vitamin D status and in vitro fertilization outcomes: a systematic review and meta-analysis. Arch Gynecol Obstet 2016; 293 (6): 1339–45; doi: 10.1007/s00404-016-4058-1
32. Holick MF. Evaluation, treatment and Prevention of Vitamin D deficiency: an Endocrine society clinical practice guideline. J Clin Metab 2011; 9: 1911–30.
2. Laura Buggio MD et al. Vitamin D and benign gynaecological diseases: A critical analysis of the current evidence, Gynecological Endocrinology; doi: 10.3109/09513590.2015.1111329
3. Громова О.А., Торшин И.Ю. Витамин D – смена парадигмы. М.: Торус Пресс, 2015. / Gromova O.A., Torshin I.Iu. Vitamin D – smena paradigmy. M.: Torus Press, 2015. [in Russian]
4. Lerchbaum E, Obermayer-Pietsch B. Vitamin D and fertility: a systematic review. Eur J Endocrinol 2012; 166 (5): 765–78.
5. Shahrokhi SZ et al. Role of vitamin D in female Reproduction. Clin Chim Acta 2016; 455: 33–8.
6. Dressler N et al. BMI and season are associated with vitamin D deficiency in women with impaired fertility: a two-centre analysis. Arch Gynecol Obstet 2016; 293 (4): 907–14.
7. Pagliardini L et al. High Prevalence of Vitamin D Deficiency in Infertile Women Referring for Assisted Reproduction. Nutrients 2015; 7 (12): 9972–84.
8. Dicken CL et al. Peripubertal vitamin D(3) deficiency delays puberty and disrupts the estrous cycle in adult female mice. Biol Reprod 2012; 87 (2): 51.
9. Irani M, Merhi Z. Role of vitamin D in ovarian physiology and its implication in reproduction: a systematic review. Fertil Steril 2014; 102 (2): 460–8.
10. Merhi Z et al. Vitamin D alters genes involved in follicular development and steroidogenesis in human cumulus granulosa cells. J Clin Endocrinol Metab 2014; 99 (6): E1137–45; doi: 10.1210/jc.2013-4161
11. Fox C et al. Local and systemic factors and implantation: what is the evidence? Fertil Steril 2016; Fertil Steril: S0015–0282(16)0013.
12. Rudick BJ. Characterizing the influence of vitamin D levels on IVF outcomes et al. Fertil Steril 2014; 101 (2).
13. Sebiha Ozkan et al. Replete vitamin D stores predict reproductive success following IVF. Fertil Steril 2010; 94 (4): 1314–9; doi:10.1016
14. Nikolaos P Polyzos et al. Vitamin D deficiency and pregnancy rates in women undergoing single embryo, blastocyst stage, transfer (SET) for IVF/ICSI. Hum Reprod 2014; 29 (9): 2032–40.
15. Laya Farzadi et al. Correlation between follicular fluid 25-OH vitamin D and assisted reproductive outcomes. Iran J Reprod Med 2015; 13(6): 361–6.
16. Lerchbaum E et al. Vitamin D and female fertility. Cur Opin Obstet Gynecol 2014; 26 (3): 145–50.
17. Abdullah UH et al. Vitamin D and assisted reproduction technologies: current concepts Association of Vitamin D with outcome after intra cytoplasmic sperm injection. J Matern Fetal Neonatal Med 2016; p. 1–16.
18. Vanni et al. Vitamin D and assisted reproduction technologies: current oncepts. Reprod Biol Endocrinol 2014; 12: 47.
19. Patra SK et al. Vitamin D as a predictor of insulin resistance in polycystic ovarian syndrome. Diabetes Metab Syndr 2012; 6 (3): 146–9.
20. Guducu N et al. 25-Hydroxyvitamin D levels are related to hyperinsulinemia in polycystic ovary syndrome. Gynecol Endocrinol 2014; 30 (8): 557–60.
21. Ngo DT et al. Determinants of insulin responsiveness in young women: Impact of polycystic ovarian syndrome, nitric oxide, and vitamin D. Nitric Oxide 2011; 25 (3): 326–30.
22. Jia XZ et al. Effect of vitamin D on clinical and biochemical parameters in polycystic ovary syndrome women: A meta-analysis. J Obstet Gynaecol Res 2015; 41 (11): 1791–802.
23. He C et al. Serum Vitamin D Levels and Polycystic Ovary syndrome: A Systematic Review and Meta-Analysis. Nutrients 2015; 7 (6): 4555–77.
24. Irani M et al. Vitamin D increases serum levels of the soluble receptor for advanced glycation end products in women with PCOS. J Clin Endocrinol Metab 2014; 99 (5): E886–90.
25. Irani M et al. Vitamin D Supplementation Decreases TGF-beta1 Bioavailability in PCOS: A Randomized Placebo-Controlled Trial. J Clin Endocrinol Metab 2015; 100 (11): 4307–14.
26. Garbedian K et al. Effect of vitamin D status on clinical pregnancy rates following in vitro fertilization. CMAJ Open 2013; doi:10.9778/cmajo.20120032
27. Panagiotis Anagnostis et al. Vitamin D in human reproduction: a narrative review. Int J Clin Pract 2013; 67 (3): 225–35; doi: 10.1111/ijcp.12031
28. Paffoni A et al. Vitamin D deficiency and infertility: insights from in vitro fertilization cycles. J Clin Endocrinol Metab 2014 Nov 99 (11): E2372-6. doi: 10.1210/jc.2014-1802.
29. Rudick BJ et al. Influence of vitamin D levels on in vitro fertilization outcomes in donor-recipient cycles. Fertil Steril 2014; 101 (2): 447–52.
30. Ozkan S et al. Replete vitamin D stores predict reproductive success following in vitro fertilization. Fertil Steril 2010; 94 (4): 1314–9.
31. Lv SS et al. Serum vitamin D status and in vitro fertilization outcomes: a systematic review and meta-analysis. Arch Gynecol Obstet 2016; 293 (6): 1339–45; doi: 10.1007/s00404-016-4058-1
32. Holick MF. Evaluation, treatment and Prevention of Vitamin D deficiency: an Endocrine society clinical practice guideline. J Clin Metab 2011; 9: 1911–30.
________________________________________________
2. Laura Buggio MD et al. Vitamin D and benign gynaecological diseases: A critical analysis of the current evidence, Gynecological Endocrinology; doi: 10.3109/09513590.2015.1111329
3. Gromova O.A., Torshin I.Iu. Vitamin D – smena paradigmy. M.: Torus Press, 2015. [in Russian]
4. Lerchbaum E, Obermayer-Pietsch B. Vitamin D and fertility: a systematic review. Eur J Endocrinol 2012; 166 (5): 765–78.
5. Shahrokhi SZ et al. Role of vitamin D in female Reproduction. Clin Chim Acta 2016; 455: 33–8.
6. Dressler N et al. BMI and season are associated with vitamin D deficiency in women with impaired fertility: a two-centre analysis. Arch Gynecol Obstet 2016; 293 (4): 907–14.
7. Pagliardini L et al. High Prevalence of Vitamin D Deficiency in Infertile Women Referring for Assisted Reproduction. Nutrients 2015; 7 (12): 9972–84.
8. Dicken CL et al. Peripubertal vitamin D(3) deficiency delays puberty and disrupts the estrous cycle in adult female mice. Biol Reprod 2012; 87 (2): 51.
9. Irani M, Merhi Z. Role of vitamin D in ovarian physiology and its implication in reproduction: a systematic review. Fertil Steril 2014; 102 (2): 460–8.
10. Merhi Z et al. Vitamin D alters genes involved in follicular development and steroidogenesis in human cumulus granulosa cells. J Clin Endocrinol Metab 2014; 99 (6): E1137–45; doi: 10.1210/jc.2013-4161
11. Fox C et al. Local and systemic factors and implantation: what is the evidence? Fertil Steril 2016; Fertil Steril: S0015–0282(16)0013.
12. Rudick BJ. Characterizing the influence of vitamin D levels on IVF outcomes et al. Fertil Steril 2014; 101 (2).
13. Sebiha Ozkan et al. Replete vitamin D stores predict reproductive success following IVF. Fertil Steril 2010; 94 (4): 1314–9; doi:10.1016
14. Nikolaos P Polyzos et al. Vitamin D deficiency and pregnancy rates in women undergoing single embryo, blastocyst stage, transfer (SET) for IVF/ICSI. Hum Reprod 2014; 29 (9): 2032–40.
15. Laya Farzadi et al. Correlation between follicular fluid 25-OH vitamin D and assisted reproductive outcomes. Iran J Reprod Med 2015; 13(6): 361–6.
16. Lerchbaum E et al. Vitamin D and female fertility. Cur Opin Obstet Gynecol 2014; 26 (3): 145–50.
17. Abdullah UH et al. Vitamin D and assisted reproduction technologies: current concepts Association of Vitamin D with outcome after intra cytoplasmic sperm injection. J Matern Fetal Neonatal Med 2016; p. 1–16.
18. Vanni et al. Vitamin D and assisted reproduction technologies: current oncepts. Reprod Biol Endocrinol 2014; 12: 47.
19. Patra SK et al. Vitamin D as a predictor of insulin resistance in polycystic ovarian syndrome. Diabetes Metab Syndr 2012; 6 (3): 146–9.
20. Guducu N et al. 25-Hydroxyvitamin D levels are related to hyperinsulinemia in polycystic ovary syndrome. Gynecol Endocrinol 2014; 30 (8): 557–60.
21. Ngo DT et al. Determinants of insulin responsiveness in young women: Impact of polycystic ovarian syndrome, nitric oxide, and vitamin D. Nitric Oxide 2011; 25 (3): 326–30.
22. Jia XZ et al. Effect of vitamin D on clinical and biochemical parameters in polycystic ovary syndrome women: A meta-analysis. J Obstet Gynaecol Res 2015; 41 (11): 1791–802.
23. He C et al. Serum Vitamin D Levels and Polycystic Ovary syndrome: A Systematic Review and Meta-Analysis. Nutrients 2015; 7 (6): 4555–77.
24. Irani M et al. Vitamin D increases serum levels of the soluble receptor for advanced glycation end products in women with PCOS. J Clin Endocrinol Metab 2014; 99 (5): E886–90.
25. Irani M et al. Vitamin D Supplementation Decreases TGF-beta1 Bioavailability in PCOS: A Randomized Placebo-Controlled Trial. J Clin Endocrinol Metab 2015; 100 (11): 4307–14.
26. Garbedian K et al. Effect of vitamin D status on clinical pregnancy rates following in vitro fertilization. CMAJ Open 2013; doi:10.9778/cmajo.20120032
27. Panagiotis Anagnostis et al. Vitamin D in human reproduction: a narrative review. Int J Clin Pract 2013; 67 (3): 225–35; doi: 10.1111/ijcp.12031
28. Paffoni A et al. Vitamin D deficiency and infertility: insights from in vitro fertilization cycles. J Clin Endocrinol Metab 2014 Nov 99 (11): E2372-6. doi: 10.1210/jc.2014-1802.
29. Rudick BJ et al. Influence of vitamin D levels on in vitro fertilization outcomes in donor-recipient cycles. Fertil Steril 2014; 101 (2): 447–52.
30. Ozkan S et al. Replete vitamin D stores predict reproductive success following in vitro fertilization. Fertil Steril 2010; 94 (4): 1314–9.
31. Lv SS et al. Serum vitamin D status and in vitro fertilization outcomes: a systematic review and meta-analysis. Arch Gynecol Obstet 2016; 293 (6): 1339–45; doi: 10.1007/s00404-016-4058-1
32. Holick MF. Evaluation, treatment and Prevention of Vitamin D deficiency: an Endocrine society clinical practice guideline. J Clin Metab 2011; 9: 1911–30.
Авторы
О.А.Громова*1, И.Ю.Торшин2, Л.К.Джиджихия3, И.В.Гоголева1
1. ГБОУ ВПО Ивановская государственная медицинская академия Минздрава России. 153462, Россия, Иваново, Шереметевский пр-т, д. 8;
2. ФГАОУ ВО Московский физико-технический институт. 141700, Россия, Долгопрудный, Институтский пер., д. 9;
3. ГБУЗ МО Московский областной научно-исследовательский институт акушерства и гинекологии. 101000, Россия, Москва, ул. Покровка, д. 22а
*unesco.gromova@gmail.com
1. Ivanovo State Medical Academy of the Ministry of Health of the Russian Federation. 153462, Russian Federation, Ivanovo, Sheremetevskii pr-t, d. 8;
2. Moscow Institute of Physics and Technology. 141700, Russian Federation, Dolgoprudnyi, Institutskii per., d. 9;
3. Moscow Regional Research Institute of Obstetrics and Gynecology. 101000, Russian Federation, Moscow, ul. Pokrovka, d. 22a
*unesco.gromova@gmail.com
1. ГБОУ ВПО Ивановская государственная медицинская академия Минздрава России. 153462, Россия, Иваново, Шереметевский пр-т, д. 8;
2. ФГАОУ ВО Московский физико-технический институт. 141700, Россия, Долгопрудный, Институтский пер., д. 9;
3. ГБУЗ МО Московский областной научно-исследовательский институт акушерства и гинекологии. 101000, Россия, Москва, ул. Покровка, д. 22а
*unesco.gromova@gmail.com
________________________________________________
1. Ivanovo State Medical Academy of the Ministry of Health of the Russian Federation. 153462, Russian Federation, Ivanovo, Sheremetevskii pr-t, d. 8;
2. Moscow Institute of Physics and Technology. 141700, Russian Federation, Dolgoprudnyi, Institutskii per., d. 9;
3. Moscow Regional Research Institute of Obstetrics and Gynecology. 101000, Russian Federation, Moscow, ul. Pokrovka, d. 22a
*unesco.gromova@gmail.com
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