Эндре Цейзель и концепция первичной профилактики врожденных пороков развития плода

1. Smithells RW, Sheppard S, Schorah CJ. Vitamin deficiencies and neural tube defects.  Arch Dis Child 1976; 51 (12): 944–50.
2. Smithells RW, Sheppard S, Schorah CJ et al. Possible prevention of neural-tube defects by periconceptional vitamin supplementation. Lancet 1980; 1 (8164): 339–40.
3. Smithells RW, Nevin NC, Seller MJ et al. Further experience of vitamin supplementation for prevention of neural tube defect recurrences. Lancet 1983; 1 (8332): 1027–31.
4. Schorah CJ, Wild J, Hartley R et al. The effect of periconceptional supplementation on blood vitamin concentrations in women at recurrence risk for neural tube defect. Br J Nutr 1983; 49 (2): 203–11.
5. Czeizel AE. Folic Acid/Folic Acid-Containing Multivitamins and Primary Prevention of Birth Defects and Preterm Birth. 2010; 643–72.
6. The Randomized Controlled Trial of Periconceptional Multivitamin Supplementation on Structural Birth Defects and Pregnancy Outcomes, 1984–1994 (http://www.socio.com/cam16.php) 
7. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. MRC Vitamin Study Research Group. Lancet 1991; 338 (8760): 131–7.
8. Berry RJ, Li Z, Erickson JD et al. Prevention of neural-tube defects with folic acid in China. China-U.S. Collaborative Project for Neural Tube Defect Prevention. N Engl J Med 1999; 341 (20): 1485–90.
9. Recommendations for the use of folic acid to reduce the number of cases of spina bifida and other neural tube defects / MMWR Recomm Rep. 1992; Vol. 41. №RR14.  1–7.
10. Czeizel AE. The primary prevention of birth defects: Multivitamins or folic acid? Int J Med Sci 2004; 1 (1): 50–61.
11. Czeizel AE, Rockenbauer M, Siffel C, Varga E. Description and mission evaluation of the Hungarian case-control surveillance of congenital abnormalities, 1980-1996. Teratology 2001; 63 (5): 176–85.
12. Периконцепционная профилактика врожденных пороков развития: диалог с профессором Эндре Цейзелем. Consilium Medicum Ukraina 2013; 5. / Perikontseptsionnaia profilaktika vrozhdennykh porokov razvitiia: dialog s professorom Endre Tseizelem. Consilium Medicum Ukraina 2013; 5. [in Russian]
13. Czeizel A, Dudás I, Vereczkey A, Bánhidy F. Folate Deficiency and Folic Acid Supplementation: The Prevention of Neural-Tube Defects and Congenital Heart Defects. Nutrients 2013; 5 (11): 4760–75.
14. Fox JT, Stover PJ. Folate-mediated one-carbon metabolism. Vitamins and hormones. 2008; 79: 1–44.
15. Yates JRW, Ferguson-Smith MA, Shenkin A et al. Is disordered folate metabolism the basis for the genetic predisposition to neural tube defects? Clin Genet 2008; 31 (5): 279–87.
16. Silaste ML, Rantala M, Sampi M et al. Polymorphisms of key enzymes in homocysteine metabolism affect diet responsiveness of plasma homocysteine in healthy women. J Nutr 2001; 131 (10): 2643–7.
17. Периконцепционная профилактика врожденных пороков развития: диалог с профессором Эндре Цейзелем. Consilium Medicum. Ukraina 2013; 10. / Perikontseptsionnaia profilaktika vrozhdennykh porokov razvitiia: dialog s professorom Endre Tseizelem. Consilium Medicum. Ukraina 2013; 10. [in Russian]
18. Lakshmaiah N, Bamji MS. Half-life and metabolism of 3H-folic acid in oral contraceptive treated rats. Horm Metab Res 1981; 13 (7): 404–7.
19. Czeizel AE, Dudas I, Paput L, Banhidy F. Prevention of neural-tube defects with periconceptional folic acid, methylfolate, or multivitamins? Ann Nutr Metab 2011; 58 (4): 263–71.
20. Prinz-Langenohl R, Bramswig S, Tobolski O et al. [6S]-5-methyltetrahydrofolate increases plasma folate more effectively than folic acid in women with the homozygous or wild-type 677C-->T polymorphism of methylenetetrahydrofolate reductase. Br J Pharmacol 2009; 158 (8): 2014–21.
21. Ambrosino P, Lupoli R, Di Minno A et al. Cyclic supplementation of 5-MTHF is effective for the correction of hyperhomocysteinemia. Nutr Res 2015; 35 (6): 489–95.
22. Кузнецова И.В., Коновалов В.А. Фолиевая кислота и ее роль в женской репродукции. Гинекология. 2014; 4: 17–23. / Kuznetsova I.V., Konovalov V.A. Folievaia kislota i ee rol' v zhenskoi reproduktsii. Ginekology. 2014; 4: 17–23. [in Russian]

________________________________________________

1. Smithells RW, Sheppard S, Schorah CJ. Vitamin deficiencies and neural tube defects.  Arch Dis Child 1976; 51 (12): 944–50.
2. Smithells RW, Sheppard S, Schorah CJ et al. Possible prevention of neural-tube defects by periconceptional vitamin supplementation. Lancet 1980; 1 (8164): 339–40.
3. Smithells RW, Nevin NC, Seller MJ et al. Further experience of vitamin supplementation for prevention of neural tube defect recurrences. Lancet 1983; 1 (8332): 1027–31.
4. Schorah CJ, Wild J, Hartley R et al. The effect of periconceptional supplementation on blood vitamin concentrations in women at recurrence risk for neural tube defect. Br J Nutr 1983; 49 (2): 203–11.
5. Czeizel AE. Folic Acid/Folic Acid-Containing Multivitamins and Primary Prevention of Birth Defects and Preterm Birth. 2010; 643–72.
6. The Randomized Controlled Trial of Periconceptional Multivitamin Supplementation on Structural Birth Defects and Pregnancy Outcomes, 1984–1994 (http://www.socio.com/cam16.php) 
7. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. MRC Vitamin Study Research Group. Lancet 1991; 338 (8760): 131–7.
8. Berry RJ, Li Z, Erickson JD et al. Prevention of neural-tube defects with folic acid in China. China-U.S. Collaborative Project for Neural Tube Defect Prevention. N Engl J Med 1999; 341 (20): 1485–90.
9. Recommendations for the use of folic acid to reduce the number of cases of spina bifida and other neural tube defects / MMWR Recomm Rep. 1992; Vol. 41. №RR14.  1–7.
10. Czeizel AE. The primary prevention of birth defects: Multivitamins or folic acid? Int J Med Sci 2004; 1 (1): 50–61.
11. Czeizel AE, Rockenbauer M, Siffel C, Varga E. Description and mission evaluation of the Hungarian case-control surveillance of congenital abnormalities, 1980-1996. Teratology 2001; 63 (5): 176–85.
12. Perikontseptsionnaia profilaktika vrozhdennykh porokov razvitiia: dialog s professorom Endre Tseizelem. Consilium Medicum Ukraina 2013; 5. [in Russian]
13. Czeizel A, Dudás I, Vereczkey A, Bánhidy F. Folate Deficiency and Folic Acid Supplementation: The Prevention of Neural-Tube Defects and Congenital Heart Defects. Nutrients 2013; 5 (11): 4760–75.
14. Fox JT, Stover PJ. Folate-mediated one-carbon metabolism. Vitamins and hormones. 2008; 79: 1–44.
15. Yates JRW, Ferguson-Smith MA, Shenkin A et al. Is disordered folate metabolism the basis for the genetic predisposition to neural tube defects? Clin Genet 2008; 31 (5): 279–87.
16. Silaste ML, Rantala M, Sampi M et al. Polymorphisms of key enzymes in homocysteine metabolism affect diet responsiveness of plasma homocysteine in healthy women. J Nutr 2001; 131 (10): 2643–7.
17. Perikontseptsionnaia profilaktika vrozhdennykh porokov razvitiia: dialog s professorom Endre Tseizelem. Consilium Medicum. Ukraina 2013; 10. [in Russian]
18. Lakshmaiah N, Bamji MS. Half-life and metabolism of 3H-folic acid in oral contraceptive treated rats. Horm Metab Res 1981; 13 (7): 404–7.
19. Czeizel AE, Dudas I, Paput L, Banhidy F. Prevention of neural-tube defects with periconceptional folic acid, methylfolate, or multivitamins? Ann Nutr Metab 2011; 58 (4): 263–71.
20. Prinz-Langenohl R, Bramswig S, Tobolski O et al. [6S]-5-methyltetrahydrofolate increases plasma folate more effectively than folic acid in women with the homozygous or wild-type 677C-->T polymorphism of methylenetetrahydrofolate reductase. Br J Pharmacol 2009; 158 (8): 2014–21.
21. Ambrosino P, Lupoli R, Di Minno A et al. Cyclic supplementation of 5-MTHF is effective for the correction of hyperhomocysteinemia. Nutr Res 2015; 35 (6): 489–95.
22. Kuznetsova I.V., Konovalov V.A. Folievaia kislota i ee rol' v zhenskoi reproduktsii. Ginekology. 2014; 4: 17–23. [in Russian]

А.Е.Донников*

ФГБУ Научный центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова Минздрава России. 117997, Россия, Москва, ул. Академика Опарина, д. 4
*donnikov@oparina4.ru

________________________________________________

A.E.Donnikov*

V.I.Kulakov Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Akademika Oparina, d. 4
*donnikov@oparina4.ru