Современные аспекты применения кальция и витамина D3 при беременности

1. Ребров В.Г., Громова О.А. Витамины, макро- и микроэлементы. М.: ГЭОТАР-Мед, 2008. / Rebrov V.G., Gromova O.A. Vitaminy, makro- i mikroelementy. M.: GEOTAR-Med, 2008. [in Russian]
2. Лиманова О.А., Торшин И.Ю., Сардарян И.С. и др. Обеспеченность микронутриентами и женское здоровье: интеллектуальный анализ клинико-эпидемиологических данных. Вопр. гинекологии, акушерства и перинатологии. 2014; 2: 5–15. / Limanova O.A., Torshin I.Iu., Sardarian I.S. i dr. Obespechennost' mikronutrientami i zhenskoe zdorov'e: intellektual'nyi analiz kliniko-epidemiologicheskikh dannykh. Vopr. ginekologii, akusherstva i perinatologii. 2014; 2: 5–15. [in Russian]
3. Громова О.А., Торшин И.Ю. Витамин D – смена парадигмы. М.: Торус Пресс, 2015. / Gromova O.A., Torshin I.Iu. Vitamin D – smena paradigmy. M.: Torus Press, 2015. [in Russian]
4. Торшин И.Ю., Громова О.А. Экспертный анализ данных в молекулярной фармакологии. М.: МЦНМО, 2012. / Torshin I.Iu., Gromova O.A. Ekspertnyi analiz dannykh v molekuliarnoi farmakologii. M.: MTsNMO, 2012. [in Russian]
5. Waller M, Murphy S, Krishnaraj N, Antunes G. Respiratory failure and symptomatic hypercalcaemia complicating pulmonary tuberculosis. BMJ Case Rep 2009; pii: bcr10.2008.1081. doi: 10.1136/bcr.10.2008.1081.
6. Громова О.А., Торшин И.Ю., Гришина Т.Р., Лисица А.В. Перспективы использования препаратов на основе органических солей кальция. Молекулярные механизмы кальция. Лечащий врач, 2013; 4:42–4. / Gromova O.A., Torshin I.Iu., Grishina T.R., Lisitsa A.V. Perspektivy ispol'zovaniia preparatov na osnove organicheskikh solei kal'tsiia. Molekuliarnye mekhanizmy kal'tsiia. Lechashchii vrach, 2013; 4:42–4. [in Russian]
7. Rayssiguier Y, Chevalier F, Gueux E et al. Glucose-stimulated insulin secretion in rats with normal plasma calcium levels: effects of calcium deficiency. J Nutr 1982; 112 (9): 1801–4.
8. Yuasa S, Sumikura T, Yura T et al. Effect of low dietary calcium intake on blood pressure and pressure natriuresis response in rats: a possible role of the renin-angiotensin system. Blood Press 1996; 5 (2): 121–7.
9. Togari A, Arai M, Shamoto T et al. Elevation of blood pressure in young rats fed a low calcium diet. Effects of nifedipine and captopril. Biochem Pharmacol 1989; 38 (6): 889–93.
10. Jolma P, Kalliovalkama J, Tolvanen JP et al. High-calcium diet enhances vasorelaxation in nitric oxide-deficient hypertension. Am J Physiol Heart Circ Physiol 2000; 279 (3): H1036–43.
11. Dwyer JH, Allayee H, Dwyer KM et al. Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis. 
N Engl J Med 2004; 350 (1): 29–37.
12. WHO Guideline: Calcium supplementation in pregnant women. Geneva, 2013 (www.who.int/nutrition/publications/micronutrients/guidelines/calcium_supplementation).
13. WHO recommendations for prevention and treatment of pre-eclampsia and eclampsia. Geneva, 2011, (www.who.int/reproductivehealth/publications/maternal_perinatal_health/ 9789241548335).
14. Tang R, Tang IC, Henry A, Welsh A. Limited evidence for calcium supplementation in preeclampsia prevention: a meta-analysis and systematic review. Hypertens Pregnancy 2015; 34 (2): 181–203.
15. Hofmeyr GJ, Lawrie TA, Atallah AN et al. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database Syst Rev 2014; 6: CD001059.
16. Hofmeyr GJ, Lawrie TA, Atallah AN, Duley L. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database Syst Rev 2010; 8: CD001059.
17. Hofmeyr GJ, Atallah AN, Duley L. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database Syst Rev 2006; 3: CD001059.
18. Imdad A, Jabeen A, Bhutta ZA. Role of calcium supplementation during pregnancy in reducing risk of developing gestational hypertensive disorders: a meta-analysis of studies from developing countries. BMC Public Health 2011; 11 (Suppl. 3): S18 doi.
19. Buppasiri P, Lumbiganon P, Thinkhamrop J et al. Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes. Cochrane Database Syst Rev 2015; 2: CD007079.
20. Buppasiri P, Lumbiganon P, Thinkhamrop J et al. Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes. Cochrane Database Syst Rev 2011;10: CD007079.
21. Perez-Lopez FR, Pasupuleti V, Mezones-Holguin E et al. Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials. Fertil Steril 2015; 103 (5): 1278-88e4 doi.
22. Horton K, Marrack J, Price I. The relation of calcium in the saliva to dental caries. Biochem J 1929; 23 (5): 1075–8.
23. Cai F, Shen P, Walker GD et al. Remineralization of enamel subsurface lesions by chewing gum with added calcium. J Dent 2009; 37 (10): 763–8. 
24. Проходная В.А., Гайворонская Т.В., Максюков С.Ю. и др. Современные особенности динамики распространенности и течения кариеса зубов среди беременных женщин, повышение эффективности профилактических мероприятий. Рос. стоматологический журн. 2015; 2: 30–3. / Prokhodnaia V.A., Gaivoronskaia T.V., Maksiukov S.Iu. i dr. Sovremennye osobennosti dinamiki rasprostranennosti i techeniia kariesa zubov sredi beremennykh zhenshchin, povyshenie effektivnosti profilakticheskikh meropriiatii. Ros. stomatologicheskii zhurn. 2015; 2: 30–3. [in Russian]
25. Бахмудов Б.Р., Алиева З.Б., Бахмудов М.Б. Анализ распространенности кариеса зубов среди беременных женщин Дербента в динамике за 10 лет наблюдения. Стоматология. 2012; 4: 60–2. / Bakhmudov B.R., Alieva Z.B., Bakhmudov M.B. Analiz rasprostranennosti kariesa zubov sredi beremennykh zhenshchin Derbenta v dinamike za 10 let nabliudeniia. Stomatologiia. 2012; 4: 60–2. [in Russian]
26. Kumar S, Tadakamadla J, Tibdewal H et al. Factors influencing caries status and treatment needs among pregnant women attending a maternity hospital in Udaipur city, India. J Clin Exp Dent 2013; 5 (2): e72-6. doi: 10.4317/jced.50982. eCollection 2013.
27. Singh S, Sharma A, Sood PB et al. Saliva as a prediction tool for dental caries: An in vivo study. J Oral Biol Craniofac Res 2015; 5 (2): 59–64.
28. Manea A, Nechifor M. Research on plasma and saliva levels of some bivalent cations in patients with chronic periodontitis (salivary cations in chronic periodontitis). Rev Med Chir Soc Med Nat Iasi 2014; 118 (2): 439–49.
29. Tanaka K, Hitsumoto S, Miyake Y et al. Higher vitamin D intake during pregnancy is associated with reduced risk of dental caries in young Japanese children. Ann Epidemiol 2015; 25 (8): 620–5.
30. Торшин И.Ю, Громова О.А., Лиманова О.А. и др. Обеспеченность витамином D детей и подростков 7–14 лет и взаимосвязь дефицита витамина D с нарушениями здоровья детей. Анализ крупномасштабной выборки пациентов посредством интеллектуального анализа данных. Педиатрия. 2015; 2: 175–84. / Torshin I.Iu, Gromova O.A., Limanova O.A. i dr. Obespechennost' vitaminom D detei i podrostkov 7–14 let i vzaimosviaz' defitsita vitamina D s narusheniiami zdorov'ia detei. Analiz krupnomasshtabnoi vyborki patsientov posredstvom intellektual'nogo analiza dannykh. Pediatriia. 2015; 2: 175–84. [in Russian]
31. Phattarataratip E, Olson B, Broffitt B et al. Streptococcus mutans strains recovered from caries-active or caries-free individuals differ in sensitivity to host antimicrobial peptides. Mol Oral Microbiol 2011; 26 (3): 187–99. doi: 10.1111/j.2041-1014.2011.00607.x
32. Holick et al. Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline J Clin Endocrinol Metabol 2011; 96 (7): 1911–30.
33. Prentice A, Schoenmakers I, Laskey MA et al. Nutrition and bone growth and development. Proc Nutr Soc 2006; 65 (4): 348–60.

________________________________________________

1. Rebrov V.G., Gromova O.A. Vitaminy, makro- i mikroelementy. M.: GEOTAR-Med, 2008. [in Russian]
2. Limanova O.A., Torshin I.Iu., Sardarian I.S. i dr. Obespechennost' mikronutrientami i zhenskoe zdorov'e: intellektual'nyi analiz kliniko-epidemiologicheskikh dannykh. Vopr. ginekologii, akusherstva i perinatologii. 2014; 2: 5–15. [in Russian]
3. Gromova O.A., Torshin I.Iu. Vitamin D – smena paradigmy. M.: Torus Press, 2015. [in Russian]
4. Torshin I.Iu., Gromova O.A. Ekspertnyi analiz dannykh v molekuliarnoi farmakologii. M.: MTsNMO, 2012. [in Russian]
5. Waller M, Murphy S, Krishnaraj N, Antunes G. Respiratory failure and symptomatic hypercalcaemia complicating pulmonary tuberculosis. BMJ Case Rep 2009; pii: bcr10.2008.1081. doi: 10.1136/bcr.10.2008.1081.
6. Gromova O.A., Torshin I.Iu., Grishina T.R., Lisitsa A.V. Perspektivy ispol'zovaniia preparatov na osnove organicheskikh solei kal'tsiia. Molekuliarnye mekhanizmy kal'tsiia. Lechashchii vrach, 2013; 4:42–4. [in Russian]
7. Rayssiguier Y, Chevalier F, Gueux E et al. Glucose-stimulated insulin secretion in rats with normal plasma calcium levels: effects of calcium deficiency. J Nutr 1982; 112 (9): 1801–4.
8. Yuasa S, Sumikura T, Yura T et al. Effect of low dietary calcium intake on blood pressure and pressure natriuresis response in rats: a possible role of the renin-angiotensin system. Blood Press 1996; 5 (2): 121–7.
9. Togari A, Arai M, Shamoto T et al. Elevation of blood pressure in young rats fed a low calcium diet. Effects of nifedipine and captopril. Biochem Pharmacol 1989; 38 (6): 889–93.
10. Jolma P, Kalliovalkama J, Tolvanen JP et al. High-calcium diet enhances vasorelaxation in nitric oxide-deficient hypertension. Am J Physiol Heart Circ Physiol 2000; 279 (3): H1036–43.
11. Dwyer JH, Allayee H, Dwyer KM et al. Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis. N Engl J Med 2004; 350 (1): 29–37.
12. WHO Guideline: Calcium supplementation in pregnant women. Geneva, 2013 (www.who.int/nutrition/publications/micronutrients/guidelines/calcium_supplementation).
13. WHO recommendations for prevention and treatment of pre-eclampsia and eclampsia. Geneva, 2011, (www.who.int/reproductivehealth/publications/maternal_perinatal_health/ 9789241548335).
14. Tang R, Tang IC, Henry A, Welsh A. Limited evidence for calcium supplementation in preeclampsia prevention: a meta-analysis and systematic review. Hypertens Pregnancy 2015; 34 (2): 181–203.
15. Hofmeyr GJ, Lawrie TA, Atallah AN et al. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database Syst Rev 2014; 6: CD001059.
16. Hofmeyr GJ, Lawrie TA, Atallah AN, Duley L. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database Syst Rev 2010; 8: CD001059.
17. Hofmeyr GJ, Atallah AN, Duley L. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database Syst Rev 2006; 3: CD001059.
18. Imdad A, Jabeen A, Bhutta ZA. Role of calcium supplementation during pregnancy in reducing risk of developing gestational hypertensive disorders: a meta-analysis of studies from developing countries. BMC Public Health 2011; 11 (Suppl. 3): S18 doi.
19. Buppasiri P, Lumbiganon P, Thinkhamrop J et al. Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes. Cochrane Database Syst Rev 2015; 2: CD007079.
20. Buppasiri P, Lumbiganon P, Thinkhamrop J et al. Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes. Cochrane Database Syst Rev 2011;10: CD007079.
21. Perez-Lopez FR, Pasupuleti V, Mezones-Holguin E et al. Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials. Fertil Steril 2015; 103 (5): 1278-88e4 doi.
22. Horton K, Marrack J, Price I. The relation of calcium in the saliva to dental caries. Biochem J 1929; 23 (5): 1075–8.
23. Cai F, Shen P, Walker GD et al. Remineralization of enamel subsurface lesions by chewing gum with added calcium. J Dent 2009; 37 (10): 763–8. 
24. Prokhodnaia V.A., Gaivoronskaia T.V., Maksiukov S.Iu. i dr. Sovremennye osobennosti dinamiki rasprostranennosti i techeniia kariesa zubov sredi beremennykh zhenshchin, povyshenie effektivnosti profilakticheskikh meropriiatii. Ros. stomatologicheskii zhurn. 2015; 2: 30–3. [in Russian]
25. Bakhmudov B.R., Alieva Z.B., Bakhmudov M.B. Analiz rasprostranennosti kariesa zubov sredi beremennykh zhenshchin Derbenta v dinamike za 10 let nabliudeniia. Stomatologiia. 2012; 4: 60–2. [in Russian]
26. Kumar S, Tadakamadla J, Tibdewal H et al. Factors influencing caries status and treatment needs among pregnant women attending a maternity hospital in Udaipur city, India. J Clin Exp Dent 2013; 5 (2): e72-6. doi: 10.4317/jced.50982. eCollection 2013.
27. Singh S, Sharma A, Sood PB et al. Saliva as a prediction tool for dental caries: An in vivo study. J Oral Biol Craniofac Res 2015; 5 (2): 59–64.
28. Manea A, Nechifor M. Research on plasma and saliva levels of some bivalent cations in patients with chronic periodontitis (salivary cations in chronic periodontitis). Rev Med Chir Soc Med Nat Iasi 2014; 118 (2): 439–49.
29. Tanaka K, Hitsumoto S, Miyake Y et al. Higher vitamin D intake during pregnancy is associated with reduced risk of dental caries in young Japanese children. Ann Epidemiol 2015; 25 (8): 620–5.
30. Torshin I.Iu, Gromova O.A., Limanova O.A. i dr. Obespechennost' vitaminom D detei i podrostkov 7–14 let i vzaimosviaz' defitsita vitamina D s narusheniiami zdorov'ia detei. Analiz krupnomasshtabnoi vyborki patsientov posredstvom intellektual'nogo analiza dannykh. Pediatriia. 2015; 2: 175–84. [in Russian]
31. Phattarataratip E, Olson B, Broffitt B et al. Streptococcus mutans strains recovered from caries-active or caries-free individuals differ in sensitivity to host antimicrobial peptides. Mol Oral Microbiol 2011; 26 (3): 187–99. doi: 10.1111/j.2041-1014.2011.00607.x
32. Holick et al. Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline J Clin Endocrinol Metabol 2011; 96 (7): 1911–30.
33. Prentice A, Schoenmakers I, Laskey MA et al. Nutrition and bone growth and development. Proc Nutr Soc 2006; 65 (4): 348–60.

О.А.Громова*1, И.Ю.Торшин2, Н.К.Тетруашвили3, И.Н.Захарова4, Т.Р.Гришина1

1. ГБОУ ВПО Ивановская государственная медицинская академия Минздрава России. 153000, Россия, Иваново, Шереметевский пр-т, д. 8;
2. ФГАОУ ВПО Московский физико-технический институт. 141700, Россия, Долгопрудный, Институтский пер., д. 9;
3. ФГБУ Научный центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова Минздрава России. 117997, Россия, Москва, ул. Академика Опарина, д. 4;
4. ГБОУ ДПО Российская медицинская академия последипломного образования Минздрава России. 
123995, Россия, Москва, ул. Баррикадная, д. 2/1
*unesco.gromova@gmail.com

________________________________________________

O.A.Gromova*1, I.Yu.Torshin2, N.K.Tetruashvili3, I.N.Zakharova4, T.R.Grishina1

1. Ivanovo State Medical Academy of the Ministry of Health of the Russian Federation. 153000, Russian Federation, Ivanovo, Sheremetevskii pr-t, d. 8;
2. Moscow Institute of Physics and Technology. 141700, Russian Federation, Dolgoprudnyi, Institutskii per., d. 9;
3. V.I.Kulakov Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Akademika Oparina, d. 4;
4. Russian Medical Academy for Postgraduate Education of the Ministry of Health of the Russian Federation. 123995, Russian Federation, Moscow, 
ul. Barrikadnaia, d. 2/1
*unesco.gromova@gmail.com