Папилломавирусная инфекция – наиболее распространенная инфекция, передаваемая половым путем. Вирус папилломы человека является причиной предраковых заболеваний аногенитальной области и экзофитных кондилом. Следует отметить особую важность оценки качества жизни у женщин с вирусом папилломы человека – ассоциированными заболеваниями шейки матки. Ключевые слова: вирус папилломы человека, цервикальные интраэпителиальные неоплазии, рак шейки матки, качество жизни.
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Human papillomavirus is likely the most common sexually transmitted viral infection worldwide. HPV provokes anogenital diseases and genital warts. It should be noted the specific importance of the quality of life assessment of the women with human papillomavirus – associated cervical diseases. Key words: human papillomavirus, cervical intraepithelial neoplasia, cervical cancer, quality of life.
1. Massad LS, Einstein MH, Huh WK et al. ASCCP Consensus Guidelines Conference (2013) 2012 updated consensus guidelines for the management of abnormal cervical cancer screening tests and cancer precursors. Obstet Gynecol 2012; 121 (4): 829–46.
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5. Guan P, Howell-Jones R, Li N et al. Human papillomavirus types in 115,789 HPV-positive women: A meta-analysis from cervical infection to cancer. Int J Cancer 2012 Feb 9.
6. Formana D, de Martelb C, Laceyc CJ et al. Global Burden of Human Papillomavirus and Related Diseases. Vaccine 2012; 30: 12–23.
7. Marcellusi A, Sc M, Capone A et al. Health Utilities lost and risk factors associated with HPV-induced diseases in men and women: The HPV Italian collaborative study group. Clin Ther 2015; 37 (1): 156–67.
8. Lang HC, Chuang L, Shun SC et al. Validation of EQ-5D in patients with cervical cancer in Taiwan. Support Care Cancer 2010; 18: 1279–86.
9. Waxman AG, Chelmow D, Darragh TM et al. Revised Terminology for Cervical Histopathology and Its Implications for Management of High-Grade Squamous Intraepithelial Lesions of the Cervix. Obstet Gynecol 2012; 120 (6): 1465–71.
10. Murasawa H, Konno R, Okubo I et al. Evaluation of health-related quality of life for hypothesized medical states associated with cervical cancer. Asian Pac J Cancer Prev 2014; 15 (22): 9679–85.
11. McCaffery K, Waller J, Forrest S et al. Testing positive for human papillomavirus in routine cervical screening: examination of psychosocial impact. BJOG 2004; 111 (12): 1437–43.
12. Maissi E, Marteau TM, Hankins M et al. Psychological impact of human papillomavirus testing in women with borderline or mildly dyskaryotic cervical smear test results: cross sectional questionnaire study. BMJ 2004; 328 (7451): 1293.
13. Bertram CC, Magnussen L. Informational needs and the experiences of women with abnormal Papanicolaou smears. J Am Acad Nurse Pract 2008; 20 (9): 55–62.
14. Waller J, McCaffery K, Kitchner H et al. Women’s experiences of repeated HPV testing in the context of cervical cancer screening: a qualitative study. Psycho-Oncology 2007; 16: 196–204.
15. Petry K.U. HPV and cervical cancer. Scand J Clin Lab Invest Suppl 2014; 244: 59–62.
16. Ball SL, Winder DM, Vaughan K et al. Analysis of human papillomavirus genotypes and viral loads in anogenital warts. J Med Virol 2011; 83: 1345–50.
17. Meyer T, Arndt R, Christophers E et al. Association of rare human papillomavirus types with genital premalignant and malignant lesions. J Infec Dis 1998; 178: 252–5.
18. Brown DR, Schroeder JM, Bryan JM et al. Detection of multiple human papillomavirus types in condylomata acuminata lesions from otherwise healthy and immunosuppressed patients. J Clin Microbiol 1999; 37: 3316–22.
19. Monteiro EF, Lacey CJN, Merrick D. The interrelationship of demographic and geospatial risk factors between four common sexually transmitted diseases. Sex Transm Infect 2005; 81: 41–6.
20. Bruni L, Diaz M, Castellsagué X et al. Cervical human papillomavirus prevalence in 5 continents: meta-analysis of 1 million women with normal cytological findings. J Infect Dis 2010; 202: 1789–99.
21. O’Mahony C. Genital warts: current and future management options. Am J Clin Dermatol 2005; 6: 239–43.
22. Wang H, Qiao YL. Human papillomavirus type-distribution in condylomata acuminata of mainland China: a meta-analysis. Int J STD 2008; 19: 680–4.
23. Ju-Fang Shi, Dian-Ju Kang, Shu-Zhen Qi et al. Impact of genital warts on health related quality of life in men and women in mainland China: a multicenter hospital-based cross-sectional study. BMC Public Health 2012; 12: 153–62.
24. Rabin R, de Charro F. EQ-5D: a measure of health status from the EuroQol Group. Ann Med 2001; 33: 337–43.
25. American Society for Clinical Oncology. Outcomes of cancer treatment for technology assessment and cancer treatment guidelines. J Clin Oncol 1996; 14 (3): 671–9.
26. Zhi-Mei Zhao, Xiong-Fei Pan, Si-Han Let al. Quality of life in women with cervical precursor lesions and cancer: a prospective, 6-month, hospital-based study in China. Chin J Cancer 2014; 33 (7): 339–45.
27. Endarti D, Riewpaiboon A, Thavorncharoensap M et al. Evaluation of Health-Related Quality of Life among Patients with Cervical Cancer in Indonesia. Asian Pac J Cancer Prev 2015; 16 (8): 3345–50.
28. Busija L, Pausenberger E, Haines TP et al. Adult measures of general health and health-related quality of life: Medical Outcomes Study Short Form 36-Item (SF-36) and Short Form 12-Item (SF-12) Health Surveys, Nottingham Health Profile (NHP), Sickness Impact Profile (SIP), Medical Outcomes Study Short Form 6D (SF-6D), Health Utilities Index Mark 3 (HUI3), Quality of Well-Being Scale (QWB), and Assessment of Quality of Life (AQoL). Arthritis Care Res (Hoboken) 2011; 63 (11): 383–412.
29. Young TA, Mukuria C, Rowen D et al. Mapping Functions in Health-Related Quality of Life: Mapping from Two Cancer-Specific Health-Related Quality-of-Life Instruments to EQ-5D-3L. Med Decis Making 2015; 35 (7): 912–26.
30. Cheung YB, Goh C, Thumboo J et al. Variability and sample size requirements of quality-of-life measures: a randomized study of three major questionnaires. J Clin Oncol 2005; 23 (22): 4936–44.
31. Wang W, Ski CF, Thompson DR, Hare DL. A psychometric evaluation of the Chinese version of the short-form cardiac depression scale. Psychosomatics 2011; 52 (5): 450–4.
32. Chen YW, Coxson HO, Reid WD. Reliability and Validity of the Brief Fatigue Inventory and Dyspnea Inventory in People With Chronic Obstructive Pulmonary Disease. J Pain Symptom Manage 2016; 3924 (16): 301–14.
33. Wang J, Lu S, Zhao S. Post-infectious and non post-infectious irritable bowel syndrome: A comparative study. Pak J Med Sci 2016; 32 (1): 116–9.
34. Paes FG, Salgado Filho N, Neto da Silva MA et al. Effect of urinary incontinence on the quality of life of asthmatic women. J Asthma 2016; 53 (5): 553–8.
35. Gagnon LH, Boucher J, Robert M. Impact of pelvic floor muscle training in the postpartum period. Int Urogynecol J 2016; 27 (2): 255–60.
36. Wang W, Chow A, Thompson DR et al. Predictors of Health-Related Quality of Life Among Patients With Myocardial Infarction. West J Nurs Res 2016; 38 (1): 43–56.
37. Mc Donough CM, Grove MR, Elledge AD, Tosteson AN. Predicting EQ-5D-US and SF-6D societal health state values from the Osteoporosis Assessment Questionnaire. Osteoporos Int 2012; 23 (2): 723–32.
38. Gauffin E, Öster C, Sjöberg F et al. Health-related quality of life (EQ-5D) early after injury predicts long-term pain after burn. Burns 2016; 21: 301–67.
39. Caruso S, Cianci S, Cariola M et al. Effects of nutraceuticals on quality of life and sexual function of perimenopausal women. J Endocrinol Invest 2016 Jun 14.
40. Katainen RE, Engblom JR, Siirtola TJ et al. Climacteric symptoms in middle-aged women with chronic somatic diseases. Maturitas 2016; 86: 17–24.
41. Bjelic-Radisic V, Jensen PT, Vlasic KK, Waldenstrom A-C. Quality of life characteristics in patients with cervical cancer. Eur J Cancer 2012; 48: 3009–18.
42. Ашрафян Л.А., Киселев В.И.. Опухоли репродуктивных органов (этиология и патогенез). М.: Дмитрейд График Групп, 2008; с. 216. / Ashrafian L.A., Kiselev V.I.. Opukholi reproduktivnykh organov (etiologiia i patogenez). M.: Dmitreid Grafik Grupp, 2008; s. 216. [in Russian]
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46. Ho GYF, Bierman R, Beardsley L et al. Natural history of cervicovaginal HPV infections in young women. NEJM 1998; 338: 423–8.
47. Кулаков В.И., Прилепская В.Н., Паавонен Й. Профилактика рака шейки матки: руководство для врачей. М.: МЕДпресс-информ, 2008. / Kulakov V.I., Prilepskaia V.N., Paavonen I. Profilaktika raka sheiki matki: rukovodstvo dlia vrachei. M.: MEDpress-inform, 2008. [in Russian]
48. Сухих Г.Т., Прилепская В.Н. Профилактика рака шейки матки: руководство для врачей. Изд. 3-е. М.: МЕДпресс-информ, 2012. / Sukhikh G.T., Prilepskaia V.N. Profilaktika raka sheiki matki: rukovodstvo dlia vrachei. Izd. 3-e. M.: MEDpress-inform, 2012. [in Russian]
49. Мынбаев О.А., Елисеева М.Ю., Доорбар Дж., Манухин И.Б. Эпидемиология, молекулярная биология, патофизиология и принципы иммунотерапии папилломавирусной инфекции. Вопр. гинекологии, акушерства и перинатологии. 2009; 8 (3): 69–79. / Mynbaev O.A., Eliseeva M.Iu., Doorbar Dzh., Manukhin I.B. Epidemiologiia, molekuliarnaia biologiia, patofiziologiia pi printsipy immunoterapii papillomavirusnoi infektsii. Vopr. ginekologii, akusherstva i perinatologii. 2009; 8 (3): 69–79. [in Russian]
50. Прилепская В.Н., Роговская С.И. Возможности Изопринозина в лечении хронических цервицитов и вагинитов. Рус. мед. журн. 2008; 16 (1): 5–9. / Prilepskaia V.N., Rogovskaia S.I. Vozmozhnosti Izoprinozina v lechenii khronicheskikh tservitsitov i vaginitov. Rus. med. zhurn. 2008; 16 (1): 5–9. [in Russian]
51. Кедрова А.Г., Леваков С.А., Челнокова Н.Н. и др. Роль профилактических осмотров и первичного приема врача в женской консультации в выявлении субклинических и латентных форм папилломавирусной инфекции шейки матки и их мониторинг. Гинекология. 2011; 13 (1): 56–62. / Kedrova A.G., Levakov S.A., Chelnokova N.N. i dr. Rol' profilakticheskikh osmotrov i pervichnogo priema vracha v zhenskoi konsul'tatsii v vyiavlenii subklinicheskikh i latentnykh form papillomavirusnoi infektsii sheiki matki i ikh monitoring. Ginekologiia. 2011; 13 (1): 56–62. [in Russian]
52. Клинышкова Т.В., Каратюк Т.И., Турчанников Д.В. Дифференцированный подход к ведению больных с цервикальной интраэпителиальной неоплазией с позиции прогнозирования. Гинекология. 2011; 13 (4): 6–40. / Klinyshkova T.V., Karatiuk T.I., Turchannikov D.V. Differentsirovannyi podkhod k vedeniiu bol'nykh s tservikal'noi intraepitelial'noi neoplaziei s pozitsii prognozirovaniia. Ginekologiia. 2011; 13 (4): 6–40. [in Russian]
53. Костава М.Н., Прилепская В.Н. Возможности терапии папилломавирусной инфекции. Рус. мед. журн. 2009; 17 (1): 9–16. / Kostava M.N., Prilepskaia V.N. Vozmozhnosti terapii papillomavirusnoi infektsii. Rus. med. zhurn. 2009; 17 (1): 9–16. [in Russian]
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1. Massad LS, Einstein MH, Huh WK et al. ASCCP Consensus Guidelines Conference (2013) 2012 updated consensus guidelines for the management of abnormal cervical cancer screening tests and cancer precursors. Obstet Gynecol 2012; 121 (4): 829–46.
2. Petrova G.V., Kaprin A.D., Starinskii V.V., Gretsova O.P. Zabolevaemost' onkologicheskimi zabolevaniiami naseleniia Rossii. Onkologiia. Zhurn. im. P.A.Gertsena. 2014; 5: 5–10. [in Russian]
3. Novik A.A., Ionova T.I., Kaind P. Kontseptsiia issledovaniia kachestva zhizni v meditsine. SPb.: Elbi, 1999. [in Russian]
4. Waxman AG, Chelmow D, Darragh TM et al. Revised Terminology for Cervical Histopathology and Its Implications for Management of High-Grade Squamous Intraepithelial Lesions of the Cervix. Obstet Gynecol 2012; 120 (6): 1465–71.
5. Guan P, Howell-Jones R, Li N et al. Human papillomavirus types in 115,789 HPV-positive women: A meta-analysis from cervical infection to cancer. Int J Cancer 2012 Feb 9.
6. Formana D, de Martelb C, Laceyc CJ et al. Global Burden of Human Papillomavirus and Related Diseases. Vaccine 2012; 30: 12–23.
7. Marcellusi A, Sc M, Capone A et al. Health Utilities lost and risk factors associated with HPV-induced diseases in men and women: The HPV Italian collaborative study group. Clin Ther 2015; 37 (1): 156–67.
8. Lang HC, Chuang L, Shun SC et al. Validation of EQ-5D in patients with cervical cancer in Taiwan. Support Care Cancer 2010; 18: 1279–86.
9. Waxman AG, Chelmow D, Darragh TM et al. Revised Terminology for Cervical Histopathology and Its Implications for Management of High-Grade Squamous Intraepithelial Lesions of the Cervix. Obstet Gynecol 2012; 120 (6): 1465–71.
10. Murasawa H, Konno R, Okubo I et al. Evaluation of health-related quality of life for hypothesized medical states associated with cervical cancer. Asian Pac J Cancer Prev 2014; 15 (22): 9679–85.
11. McCaffery K, Waller J, Forrest S et al. Testing positive for human papillomavirus in routine cervical screening: examination of psychosocial impact. BJOG 2004; 111 (12): 1437–43.
12. Maissi E, Marteau TM, Hankins M et al. Psychological impact of human papillomavirus testing in women with borderline or mildly dyskaryotic cervical smear test results: cross sectional questionnaire study. BMJ 2004; 328 (7451): 1293.
13. Bertram CC, Magnussen L. Informational needs and the experiences of women with abnormal Papanicolaou smears. J Am Acad Nurse Pract 2008; 20 (9): 55–62.
14. Waller J, McCaffery K, Kitchner H et al. Women’s experiences of repeated HPV testing in the context of cervical cancer screening: a qualitative study. Psycho-Oncology 2007; 16: 196–204.
15. Petry K.U. HPV and cervical cancer. Scand J Clin Lab Invest Suppl 2014; 244: 59–62.
16. Ball SL, Winder DM, Vaughan K et al. Analysis of human papillomavirus genotypes and viral loads in anogenital warts. J Med Virol 2011; 83: 1345–50.
17. Meyer T, Arndt R, Christophers E et al. Association of rare human papillomavirus types with genital premalignant and malignant lesions. J Infec Dis 1998; 178: 252–5.
18. Brown DR, Schroeder JM, Bryan JM et al. Detection of multiple human papillomavirus types in condylomata acuminata lesions from otherwise healthy and immunosuppressed patients. J Clin Microbiol 1999; 37: 3316–22.
19. Monteiro EF, Lacey CJN, Merrick D. The interrelationship of demographic and geospatial risk factors between four common sexually transmitted diseases. Sex Transm Infect 2005; 81: 41–6.
20. Bruni L, Diaz M, Castellsagué X et al. Cervical human papillomavirus prevalence in 5 continents: meta-analysis of 1 million women with normal cytological findings. J Infect Dis 2010; 202: 1789–99.
21. O’Mahony C. Genital warts: current and future management options. Am J Clin Dermatol 2005; 6: 239–43.
22. Wang H, Qiao YL. Human papillomavirus type-distribution in condylomata acuminata of mainland China: a meta-analysis. Int J STD 2008; 19: 680–4.
23. Ju-Fang Shi, Dian-Ju Kang, Shu-Zhen Qi et al. Impact of genital warts on health related quality of life in men and women in mainland China: a multicenter hospital-based cross-sectional study. BMC Public Health 2012; 12: 153–62.
24. Rabin R, de Charro F. EQ-5D: a measure of health status from the EuroQol Group. Ann Med 2001; 33: 337–43.
25. American Society for Clinical Oncology. Outcomes of cancer treatment for technology assessment and cancer treatment guidelines. J Clin Oncol 1996; 14 (3): 671–9.
26. Zhi-Mei Zhao, Xiong-Fei Pan, Si-Han Let al. Quality of life in women with cervical precursor lesions and cancer: a prospective, 6-month, hospital-based study in China. Chin J Cancer 2014; 33 (7): 339–45.
27. Endarti D, Riewpaiboon A, Thavorncharoensap M et al. Evaluation of Health-Related Quality of Life among Patients with Cervical Cancer in Indonesia. Asian Pac J Cancer Prev 2015; 16 (8): 3345–50.
28. Busija L, Pausenberger E, Haines TP et al. Adult measures of general health and health-related quality of life: Medical Outcomes Study Short Form 36-Item (SF-36) and Short Form 12-Item (SF-12) Health Surveys, Nottingham Health Profile (NHP), Sickness Impact Profile (SIP), Medical Outcomes Study Short Form 6D (SF-6D), Health Utilities Index Mark 3 (HUI3), Quality of Well-Being Scale (QWB), and Assessment of Quality of Life (AQoL). Arthritis Care Res (Hoboken) 2011; 63 (11): 383–412.
29. Young TA, Mukuria C, Rowen D et al. Mapping Functions in Health-Related Quality of Life: Mapping from Two Cancer-Specific Health-Related Quality-of-Life Instruments to EQ-5D-3L. Med Decis Making 2015; 35 (7): 912–26.
30. Cheung YB, Goh C, Thumboo J et al. Variability and sample size requirements of quality-of-life measures: a randomized study of three major questionnaires. J Clin Oncol 2005; 23 (22): 4936–44.
31. Wang W, Ski CF, Thompson DR, Hare DL. A psychometric evaluation of the Chinese version of the short-form cardiac depression scale. Psychosomatics 2011; 52 (5): 450–4.
32. Chen YW, Coxson HO, Reid WD. Reliability and Validity of the Brief Fatigue Inventory and Dyspnea Inventory in People With Chronic Obstructive Pulmonary Disease. J Pain Symptom Manage 2016; 3924 (16): 301–14.
33. Wang J, Lu S, Zhao S. Post-infectious and non post-infectious irritable bowel syndrome: A comparative study. Pak J Med Sci 2016; 32 (1): 116–9.
34. Paes FG, Salgado Filho N, Neto da Silva MA et al. Effect of urinary incontinence on the quality of life of asthmatic women. J Asthma 2016; 53 (5): 553–8.
35. Gagnon LH, Boucher J, Robert M. Impact of pelvic floor muscle training in the postpartum period. Int Urogynecol J 2016; 27 (2): 255–60.
36. Wang W, Chow A, Thompson DR et al. Predictors of Health-Related Quality of Life Among Patients With Myocardial Infarction. West J Nurs Res 2016; 38 (1): 43–56.
37. Mc Donough CM, Grove MR, Elledge AD, Tosteson AN. Predicting EQ-5D-US and SF-6D societal health state values from the Osteoporosis Assessment Questionnaire. Osteoporos Int 2012; 23 (2): 723–32.
38. Gauffin E, Öster C, Sjöberg F et al. Health-related quality of life (EQ-5D) early after injury predicts long-term pain after burn. Burns 2016; 21: 301–67.
39. Caruso S, Cianci S, Cariola M et al. Effects of nutraceuticals on quality of life and sexual function of perimenopausal women. J Endocrinol Invest 2016 Jun 14.
40. Katainen RE, Engblom JR, Siirtola TJ et al. Climacteric symptoms in middle-aged women with chronic somatic diseases. Maturitas 2016; 86: 17–24.
41. Bjelic-Radisic V, Jensen PT, Vlasic KK, Waldenstrom A-C. Quality of life characteristics in patients with cervical cancer. Eur J Cancer 2012; 48: 3009–18.
42. Ashrafian L.A., Kiselev V.I.. Opukholi reproduktivnykh organov (etiologiia i patogenez). M.: Dmitreid Grafik Grupp, 2008; s. 216. [in Russian]
43. Prilepskaia V.N. Zabolevaniia sheiki matki, vlagalishcha, vul'vy. M.: MEDpress-inform, 2005. [in Russian]
44. Rogovskaia S.I. Papillomavirusnaia infektsiia u zhenshchin i patologiia sheiki matki: v pomoshch' praktikuiushchemu vrachu. Izd. 2-e. M.: GEOTAR-Media, 2008. [in Russian]
45. Saslow D еt al. American Cancer Society Guideline for the Early Detection of Cervical Neoplasia and Cancer. CA Cancer J Clin 2002; 52: 342–62.
46. Ho GYF, Bierman R, Beardsley L et al. Natural history of cervicovaginal HPV infections in young women. NEJM 1998; 338: 423–8.
47. Kulakov V.I., Prilepskaia V.N., Paavonen I. Profilaktika raka sheiki matki: rukovodstvo dlia vrachei. M.: MEDpress-inform, 2008. [in Russian]
48. Sukhikh G.T., Prilepskaia V.N. Profilaktika raka sheiki matki: rukovodstvo dlia vrachei. Izd. 3-e. M.: MEDpress-inform, 2012. [in Russian]
49. Mynbaev O.A., Eliseeva M.Iu., Doorbar Dzh., Manukhin I.B. Epidemiologiia, molekuliarnaia biologiia, patofiziologiia pi printsipy immunoterapii papillomavirusnoi infektsii. Vopr. ginekologii, akusherstva i perinatologii. 2009; 8 (3): 69–79. [in Russian]
50. Prilepskaia V.N., Rogovskaia S.I. Vozmozhnosti Izoprinozina v lechenii khronicheskikh tservitsitov i vaginitov. Rus. med. zhurn. 2008; 16 (1): 5–9. [in Russian]
51. Kedrova A.G., Levakov S.A., Chelnokova N.N. i dr. Rol' profilakticheskikh osmotrov i pervichnogo priema vracha v zhenskoi konsul'tatsii v vyiavlenii subklinicheskikh i latentnykh form papillomavirusnoi infektsii sheiki matki i ikh monitoring. Ginekologiia. 2011; 13 (1): 56–62. [in Russian]
52. Klinyshkova T.V., Karatiuk T.I., Turchannikov D.V. Differentsirovannyi podkhod k vedeniiu bol'nykh s tservikal'noi intraepitelial'noi neoplaziei s pozitsii prognozirovaniia. Ginekologiia. 2011; 13 (4): 6–40. [in Russian]
53. Kostava M.N., Prilepskaia V.N. Vozmozhnosti terapii papillomavirusnoi infektsii. Rus. med. zhurn. 2009; 17 (1): 9–16. [in Russian]
54. Shvarts G.Ia., Prilepskaia V.N, Mynbaev O.A. Izoprinozin v lechenii papillomavirusnoi infektsii v ginekologicheskoi praktike. M., 2011. [in Russian]
ФГБУ Научный центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова Минздрава России. 117997, Россия, Москва, ул. Академика Опарина, д. 4
*el.bona@mail.ru
V.I.Kulakov Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation. 117997,
Russian Federation, Moscow, ul. Akademika Oparina, d. 4
*el.bona@mail.ru