Диффузные заболевания молочной железы: новый вектор таргетной терапии

1. Каприн А.Д., Сталинский В.В., Петрова Г.В. Злокачественные новообразования в России в 2015 году (заболеваемость и смертность). М.: МНИОИ им. П.А.Герцена. Филиал ФГБУ «НМИРЦ» Минздрава России, 2017; с. 250. / Kaprin A.D., Stalinskii V.V., Petrova G.V. Zlokachestvennye novoobrazovaniia v Rossii v 2015 godu (zabolevaemost' i smertnost'). M.: MNIOI im. P.A.Gertsena. Filial FGBU «NMIRTs» Minzdrava Rossii, 2017; s. 250. [in Russian]
2. Ferlay J, Soerjomataram I, Dikshit R et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2015; 136: 359–86. doi:10.1002/ijc.29210
3. Рожкова Н.И., Меских Е.В., Бурдина Л.М. и др. Лекарственная па- тогенетическая коррекция доброкачественных заболеваний молочной железы. Опухоли женской репродуктивной системы. 2008; 2: 48–54. / Rozhkova N.I., Meskikh E.V., Burdina L.M. i dr. Le- karstvennaia patogeneticheskaia korrektsiia dobrokachestvennykh zabolevanii molochnoi zhelezy. Opukholi zhenskoi reproduktivnoi si- stemy. 2008; 2: 48–54. [in Russian] 
4. NCCN – Evidence-Based Cancer Guidelines. https://www.nccn.org/
5. Senkus E, Kyriakides S, Ohno S et al. Primary Breast Cancer: ESMO Clin Pract Guidelines Ann Oncol 2015; 26 (5): 8–30. DOI: https://doi.org/10.1093/annonc/mdv298.
6. WHO, corp-author. Breast cancer: Prevention and control. http://www.who.int/cancer/detection/breastcancer/en/index1.html 
7. Васильев Д.А., Зайцев А.Н., Берштейн Л.М. Маммографическая плотность молочных желез и определяющие ее факторы в свете повышенного онкологического риска. Опухоли женской репродуктивной системы. 2011; 3: 15–22. DOI: 10.17650/1994-4098-2011-0-3-15-22. / Vasil'ev D.A., Zaitsev A.N., Bershtein L.M. Mammograficheskaia plotnost' molochnykh zhelez i opredeliaiushchie ee faktory v svete povyshennogo onkologicheskogo riska. Opukholi zhenskoi reproduktivnoi sistemy. 2011; 3: 15–22. DOI: 10.17650/1994-4098-2011-0-3-15-22. [in Russian]
8. Pettersson A, Graff RE, Ursin G et al. Mammographic density phenotypes and risk of dreast cancer: a meta‐analysis. J Natl Cancer Inst 2014; 106 (5); pii: dju078.
9. Li T, Sun L, Miller N et al. The association of measured breast tissue characteristics with mammographic density and other risk factors for breast cancer. Cancer Epidemiol Biomark Prev 2005; 14 (2): 343–9.
10. Беспалов В.Г., Травина М.Л. Фиброзно-кистозная болезнь и риск рака молочной железы (обзор литературы). Опухоли женской репродуктивной системы. 2015; 11 (4): 58–70. DOI: 10.17650/1994-4098-2015-11-4-58-70. / Bespalov V.G., Travina M.L. Fibrozno-kistoznaia bolezn' i risk raka molochnoi zhelezy (obzor literatury). Opukholi zhenskoi reproduktivnoi sistemy. 2015; 11 (4): 58–70. DOI: 10.17650/1994-4098-2015-11-4-58-70. [in Russian]
11. Santen RJ. Benign Breast Disease in Women. Source Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc., 2000–2017.
12. Tice JA, Miglioretti DL, Li CS et al. Breast density and benign breast disease: risk assessment to identify women at high risk of breast cancer. J Clin Oncol 2015; 33 (28): 3137–43.
13. Boyd NF, Jensen HM, Cooke G et al. Mammographic densities and the prevalence and incidence of histological types of benign breast disease. Reference Pathologists of the Canadian National Breast Screening Study. Eur J Cancer Prev 2000; 9 (1): 15–24.
14. Международная статистическая классификация болезней и проблем, связанных со здоровьем (10-й пересмотр). Всемирная организация здравоохранения. М., 1998. / Mezhdunarodnaia statisticheskaia klassifikatsiia boleznei i problem, sviazannykh so zdorov'em (10-i peresmotr). Vsemirnaia organizatsiia zdravookhraneniia. M., 1998. [in Russian]
15. Приказ №572-н от 12.11.2012. М., 2014; с. 18–9. / Prikaz №572-n ot 12.11.2012. M., 2014; s. 18–9. [in Russian]
16. Ader DN, Browne MW. Prevalence and impact of cyclic mastalgia in a United States clinic-based sample. Am J Obstet Gynecol 1997; 177 (1): 126–32.
17. Goodwin PJ, Miller A, Del Giudice ME, Ritchie K. Breast health and associated premenstrual symptoms in women with severe cyclic mastopathy. Am J Obstet Gynecol 1997; 176 (5): 998–1005.
18. Griffith CD, Dowle CS, Hinton CP, Blamey RW. The breast pain clinic: a rational approach to classification and treatment of breast pain. Postgrad Med J 1987; 63 (741): 547–9.
19. Leinster SJ, Whitehouse GH, Walsh PV. Cyclical mastalgia: clinical and mammographic observations in a screened population. Br J Surg 1987; 74 (3): 220–2.
20. Maddox PR, Harrison BJ, Mansel RE, Hughes LE. Non-cyclical mastalgia: an improved classification and treatment. Br J Surg 1989; 76 (9): 901–4.
21. Mansel RE. ABC of breast diseases. Breast pain. BMJ 1994; 309 (6958): 866–8.
22. Olawaiye A, Withiam-Leitch M, Danakas G, Kahn K. Mastalgia: a review of management. J Reprod Med 2005; 50 (12): 933–9.
23. Barton MB, Elmore JG, Fletcher SW. Breast symptoms among women enrolled in a health maintenance organization: frequency, evaluation, and outcome. Ann Intern Med 1999; 130 (8): 651–7.
24. Fentiman IS, Hamed H. Assessment of breast problems. Int J Clin Pract 2001; 55 (7): 458–60.
25. Preece PE, Mansel RE, Bolton PM et al. Clinical syndromes of mastalgia. Lancet 1976; 2 (7987): 670–3.
26. Vaidyanathan L, Barnard K, Elnicki DM. Benign breast disease: when to treat, when to reassure, when to refer. Cleve Clin J Med 2002; 69 (5): 425–32.
27. Ашрафян Л.А., Бабаева Н.А., Антонова И.Б. и др. Уровень баланса эстрогенных метаболитов при раке молочной железы и пути его коррекции. Опухоли женской репродуктивной системы. 2015; 11 (3): 22–9. DOI: 10.17650/1994-4098-2015-11-3-22-29. / Ashrafian L.A., Babaeva N.A., Antonova I.B. i dr. Uroven' balansa estrogennykh metabolitov pri rake molochnoi zhelezy i puti ego korrektsii. Opukholi zhenskoi reproduktivnoi sistemy. 2015; 11 (3): 22–9. DOI: 10.17650/1994-4098-2015-11-3-22-29. [in Russian]
28. Сметник В.П., Коновалова В.Н. Молочная железа как своеобразный интракринный орган. Вестн. репродуктивного здоровья. 2009; 1: 39–44. / Smetnik V.P., Konovalova V.N. Molochnaia zheleza kak svoeobraznyi intrakrinnyi organ. Vestn. reproduktivnogo zdorov'ia. 2009; 1: 39–44. [in Russian]
29. Коган И.Ю., Мясникова М.О. Диагностика и лечение мастопатии. СПб., 2010. / Kogan I.Iu., Miasnikova M.O. Diagnostika i lechenie mastopatii. SPb., 2010. [in Russian]
30. Mansel RE, Webster DJ, Sweetland HM. Breast pain and nodularity. In: Benign disorders and diseases of the breast. Elsevier 2009; p. 107–39.
31. Бурдина Л.М. Диагностика и лечение доброкачественных патологических изменений молочных желез. Терапевт. архив. 1998; 10 (70): 37–41. / Burdina L.M. Diagnostika i lechenie dobrokachestvennykh patologicheskikh izmenenii molochnykh zhelez. Terapevt. arkhiv. 1998; 10 (70): 37–41. [in Russian]
32. Бурдина Л.М. Лечение заболеваний молочных желез и сопутствующих нарушений менструальной функции мастодиноном. Лечащий врач. 1999; 8: 13–6. / Burdina L.M. Lechenie zabolevanii molochnykh zhelez i soputstvuiushchikh narushenii menstrual'noi funktsii mastodinonom. Lechashchii vrach. 1999; 8: 13–6. [in Russian]
33. Klimberg SV. Etiology and management of breast pain. In: Bland KI, Copeland EM, eds. The breast: comprehensive management of benign and malignant diseases. 4th ed. Philadelphia, PA: Saunders Elsevier, 2009; p. 87–96, 123–8.
34. Kullberg C, Selander J, Albin M. Female white-collar workers remain at higher risk of breast cancer after adjustments for individual risk factors related to reproduction and lifestyle. Occup Environ Med 2017; 4. pii: oemed-2016-104043. DOI: 10.1136/oemed-2016-104043.
35. Davies EL, Gateley CA, Miers M, Mansel RE. The long-term course of mastalgia. J R Soc Med 1998; 91 (9): 462–4.
36. Wisbey JR, Kumar S, Mansel RE et al. Natural history of breast pain. Lancet 1983; 2 (8351): 672–4.
37. Onstad M, Stuckey A. Benign breast disorders. Obstet Gynecol Clin North Am 2013; 40 (3): 459–73.
38. Ader DN, Shriver CD, Browne MW. Cyclical mastalgia: premenstrual syndrome or recurrent pain disorder? J Psychosom Obstet Gynaecol 1999; 20 (4): 198–202.
39. Wetzig NR. Mastalgia: a 3 year Australian study. Aust N Z J Surg 1994; 64 (5): 329–31.
40. Morrow M. Management of common breast disorders: breast pain. In: Harris JR, ed. Breast diseases. 2nd ed.Philadelphia: Lippincott, 1991; p. 63–71.
41. Plu-Bureau G, Le MG, Sitruk-Ware R, Thalabard JC. Cyclical mastalgia and breast cancer risk: results of a French cohort study. Cancer Epidemiol Biomarkers Prev 2006; 15 (6): 1229–31.
42. Smallwood JA, Kye DA, Taylor I. Mastalgia; is this commonly associated with operable breast cancer? Ann R Coll Surg Engl 1986; 68 (5): 262–3.
43. Khan SA, Apkarian AV. Mastalgia and breast cancer: a protective association? Cancer Detect Prev 2002; 26 (3): 192–6.
44. Duijm LE, Guit GL, Hendriks JH et al. Value of breast imaging in women with painful breasts:observational follow up study. BMJ 1998; 317 (7171): 1492–5.
45. Fariselli G, Lepera P, Viganotti G et al. Localized mastalgia as presenting symptom in breast cancer. Eur J Surg Oncol 1988; 14 (3): 213–5.
46. Philip J, Wijesinghe DP, Harris WG, Rustage JH. Importance of mastalgia in operable breast cancer. Br Med J (Clin Res Ed) 1982; 285 (6334): 58.
47. Preece PE, Baum M, Mansel RE et al. Importance of mastalgia in operable breast cancer. Br Med J (Clin Res Ed) 1982; 284 (6325): 1299–300.
48. Chiedozie LC, Guirguis MN. Mastalgia and breast tumour in Nigerian women. West Afr J Med 1990; 9 (1): 54–8.
49. McClenathan JH, de la Roza G. Adenoid cystic breast cancer. Am J Surg 2002; 183 (6): 646–9.
50. Dyrstad SW, Yan Y, Fowler AM, Colditz GA. Breast cancer risk associated with benign breast disease: systematic review and meta‐analysis. Breast Cancer Res Treatment 2015; 149 (3): 569–75. DOI: 10.1007/s10549-014-3254-6.
51. Saenz RB. Evaluation of common breast problems in family practice. Am Fam Physician 2000; 61 (8): 2327–8.
52. Dobrosavljević A, Rakić S, Nikoli B et al. Diagnostic value of breast ultrasound in mammography BI-RADS 0 and clinically indeterminate or suspicious of malignancy breast lesions. Vojnosanit Pregl 2016; 73 (3): 239–45. PMID: 27295907.
53. American College of Radiology. ACR Practice Guideline for the Performance of Screening and Diagnostic Mammography. 2013; http://www.acr.org/~/media/ACR /Documents/PGTS/ guidelines/Screening_Mammography.pdf.
54. Silvera S, Rohan T. Benign proliferative epithelial disorders of the breast: a review of the epidemiologic evidence. Breast Cancer Res Treat-ment 2008; 110 (3): 397–409.
55. Leung JW, Kornguth PJ, Gotway MB. Utility of targeted sonography in the evaluation of focal breast pain. J Ultrasound Med 2002; 21 (5): 521–6; quiz 528–9.
56. Tumyan L, Hoyt AC, Bassett LW. Negative predictive value of sonography and mammography in patients with focal breast pain. Breast J 2005; 11 (5): 333–7.
57. Brandt KR, Craig DA, Hoskins TL et al. Can digital breast tomosynthesis replace conventional diagnostic mammography views for screening recalls without calcifications? A comparison study in a simulated clinical setting. AJR Am J Roentgenol 2013; 200 (2): 291–8.
58. Высоцкая И.В., Летягин В.П., Ким Е.А., Левкина Н.В. Практические рекомендации по лекарственной коррекции диффузной дисгормональной дисплазии молочных желез. Опухоли женской репродуктивной системы. 2014; 2: 45–52. / Vysotskaia I.V., Letiagin V.P., Kim E.A., Levkina N.V. Prakticheskie rekomendatsii po lekarstvennoi korrektsii diffuznoi disgormonal'noi displazii molochnykh zhelez. Opukholi zhenskoi reproduktivnoi sistemy. 2014; 2: 45–52. [in Russian]
59. Доброкачественные дисплазии молочных желез: патогенетический вектор лечения. Обзор исследований, клинические рекомендации. Информационный бюллетень. Под ред. Е.Н.Андреевой, Н.И.Рожковой, Д.А.Соколовой. М.: StatusPraesens, 2016. / Dobroka-chestvennye displazii molochnykh zhelez: patogeneticheskii vektor lecheniia. Obzor issledovanii, klinicheskie rekomendatsii. Informatsionnyi biulleten'. Pod red. E.N.Andreevoi, N.I.Rozhkovoi, D.A.Sokolovoi. M.: StatusPraesens, 2016. [in Russian]
60. Имянитов Е.Н. Общие представления о таргетной терапии. Практическая онкология. 2010. 11 (3); 123–30. / Imianitov E.N. Obshchie predstavleniia o targetnoi terapii. Prakticheskaia onkologiia. 2010. 11 (3); 123–30. [in Russian]
61. Strebhardt K, Ullrich A. Paul Ehrlich’s magic bullet concept: 100 years of progress. Nat Rev Cancer 2008; 8: 473–80.
62. Высоцкая И.В., Летягин В.П., Черенков В.Г. и др. Клинические рекомендации РООМ по профилактике РМЖ, дифференциальной диагностике, лечению предопухолевых и доброкачественных заболеваний молочных желез. М., 2015. / Vysotskaia I.V., Letiagin V.P., Cherenkov V.G. i dr. Klinicheskie rekomendatsii ROOM po profilaktike RMZh, differentsial'noi diagnostike, lecheniiu predopukholevykh i dobrokachestvennykh zabolevanii molochnykh zhelez. M., 2015. [in Russian]
63. Pasqualini JR. Differential effects of progestins on breast tissue enzymes. Maturitas 2003; 46 (Suppl. l): S45–54.
64. Коган И.Ю., Мусина Е.В. Местное применение микронизированного прогестерона у больных репродуктивного возраста с мастопатией. Акуш. и гинекол. 2012; 2: 102–6. / Kogan I.Iu., Musina E.V. Mestnoe primenenie mikronizirovannogo progesterona u bol'nykh reproduktivnogo vozrasta s mastopatiei. Akush. i ginekol. 2012; 2: 102–6. [in Russian]
65. Меских Е.В., Рожкова Н.И. Применение прожестожеля при диффузных формах мастопатии. Опухоли женской репродуктивной системы. 2012; 1: 57–60. / Meskikh E.V., Rozhkova N.I. Primenenie prozhestozhelia pri diffuznykh formakh mastopatii. Opukholi zhenskoi reproduktivnoi sistemy. 2012; 1: 57–60. [in Russian]
66. Пашов А.И., Коренев С.В. Доброкачественная дисплазия молочной железы в практике акушера-гинеколога. Калининград, 2015. / Pashov A.I., Korenev S.V. Dobrokachestvennaia displaziia molochnoi zhelezy v praktike akushera-ginekologa. Kaliningrad, 2015. [in Russian]

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1. Kaprin A.D., Stalinskii V.V., Petrova G.V. Zlokachestvennye novoobrazovaniia v Rossii v 2015 godu (zabolevaemost' i smertnost'). M.: MNIOI im. P.A.Gertsena. Filial FGBU «NMIRTs» Minzdrava Rossii, 2017; s. 250. [in Russian]
2. Ferlay J, Soerjomataram I, Dikshit R et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2015; 136: 359–86. doi:10.1002/ijc.29210
3. Rozhkova N.I., Meskikh E.V., Burdina L.M. i dr. Le- karstvennaia patogeneticheskaia korrektsiia dobrokachestvennykh zabolevanii molochnoi zhelezy. Opukholi zhenskoi reproduktivnoi si- stemy. 2008; 2: 48–54. [in Russian] 
4. NCCN – Evidence-Based Cancer Guidelines. https://www.nccn.org/
5. Senkus E, Kyriakides S, Ohno S et al. Primary Breast Cancer: ESMO Clin Pract Guidelines Ann Oncol 2015; 26 (5): 8–30. DOI: https://doi.org/10.1093/annonc/mdv298.
6. WHO, corp-author. Breast cancer: Prevention and control. http://www.who.int/cancer/detection/breastcancer/en/index1.html 
7. Vasil'ev D.A., Zaitsev A.N., Bershtein L.M. Mammograficheskaia plotnost' molochnykh zhelez i opredeliaiushchie ee faktory v svete povyshennogo onkologicheskogo riska. Opukholi zhenskoi reproduktivnoi sistemy. 2011; 3: 15–22. DOI: 10.17650/1994-4098-2011-0-3-15-22. [in Russian]
8. Pettersson A, Graff RE, Ursin G et al. Mammographic density phenotypes and risk of dreast cancer: a meta‐analysis. J Natl Cancer Inst 2014; 106 (5); pii: dju078.
9. Li T, Sun L, Miller N et al. The association of measured breast tissue characteristics with mammographic density and other risk factors for breast cancer. Cancer Epidemiol Biomark Prev 2005; 14 (2): 343–9.
10. Bespalov V.G., Travina M.L. Fibrozno-kistoznaia bolezn' i risk raka molochnoi zhelezy (obzor literatury). Opukholi zhenskoi reproduktivnoi sistemy. 2015; 11 (4): 58–70. DOI: 10.17650/1994-4098-2015-11-4-58-70. [in Russian]
11. Santen RJ. Benign Breast Disease in Women. Source Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc., 2000–2017.
12. Tice JA, Miglioretti DL, Li CS et al. Breast density and benign breast disease: risk assessment to identify women at high risk of breast cancer. J Clin Oncol 2015; 33 (28): 3137–43.
13. Boyd NF, Jensen HM, Cooke G et al. Mammographic densities and the prevalence and incidence of histological types of benign breast disease. Reference Pathologists of the Canadian National Breast Screening Study. Eur J Cancer Prev 2000; 9 (1): 15–24.
14. Mezhdunarodnaia statisticheskaia klassifikatsiia boleznei i problem, sviazannykh so zdorov'em (10-i peresmotr). Vsemirnaia organizatsiia zdravookhraneniia. M., 1998. [in Russian]
15. Prikaz №572-n ot 12.11.2012. M., 2014; s. 18–9. [in Russian]
16. Ader DN, Browne MW. Prevalence and impact of cyclic mastalgia in a United States clinic-based sample. Am J Obstet Gynecol 1997; 177 (1): 126–32.
17. Goodwin PJ, Miller A, Del Giudice ME, Ritchie K. Breast health and associated premenstrual symptoms in women with severe cyclic mastopathy. Am J Obstet Gynecol 1997; 176 (5): 998–1005.
18. Griffith CD, Dowle CS, Hinton CP, Blamey RW. The breast pain clinic: a rational approach to classification and treatment of breast pain. Postgrad Med J 1987; 63 (741): 547–9.
19. Leinster SJ, Whitehouse GH, Walsh PV. Cyclical mastalgia: clinical and mammographic observations in a screened population. Br J Surg 1987; 74 (3): 220–2.
20. Maddox PR, Harrison BJ, Mansel RE, Hughes LE. Non-cyclical mastalgia: an improved classification and treatment. Br J Surg 1989; 76 (9): 901–4.
21. Mansel RE. ABC of breast diseases. Breast pain. BMJ 1994; 309 (6958): 866–8.
22. Olawaiye A, Withiam-Leitch M, Danakas G, Kahn K. Mastalgia: a review of management. J Reprod Med 2005; 50 (12): 933–9.
23. Barton MB, Elmore JG, Fletcher SW. Breast symptoms among women enrolled in a health maintenance organization: frequency, evaluation, and outcome. Ann Intern Med 1999; 130 (8): 651–7.
24. Fentiman IS, Hamed H. Assessment of breast problems. Int J Clin Pract 2001; 55 (7): 458–60.
25. Preece PE, Mansel RE, Bolton PM et al. Clinical syndromes of mastalgia. Lancet 1976; 2 (7987): 670–3.
26. Vaidyanathan L, Barnard K, Elnicki DM. Benign breast disease: when to treat, when to reassure, when to refer. Cleve Clin J Med 2002; 69 (5): 425–32.
27. Ashrafian L.A., Babaeva N.A., Antonova I.B. i dr. Uroven' balansa estrogennykh metabolitov pri rake molochnoi zhelezy i puti ego korrektsii. Opukholi zhenskoi reproduktivnoi sistemy. 2015; 11 (3): 22–9. DOI: 10.17650/1994-4098-2015-11-3-22-29. [in Russian]
28. Smetnik V.P., Konovalova V.N. Molochnaia zheleza kak svoeobraznyi intrakrinnyi organ. Vestn. reproduktivnogo zdorov'ia. 2009; 1: 39–44. [in Russian]
29. Kogan I.Iu., Miasnikova M.O. Diagnostika i lechenie mastopatii. SPb., 2010. [in Russian]
30. Mansel RE, Webster DJ, Sweetland HM. Breast pain and nodularity. In: Benign disorders and diseases of the breast. Elsevier 2009; p. 107–39.
31. Burdina L.M. Diagnostika i lechenie dobrokachestvennykh patologicheskikh izmenenii molochnykh zhelez. Terapevt. arkhiv. 1998; 10 (70): 37–41. [in Russian]
32. Burdina L.M. Lechenie zabolevanii molochnykh zhelez i soputstvuiushchikh narushenii menstrual'noi funktsii mastodinonom. Lechashchii vrach. 1999; 8: 13–6. [in Russian]
33. Klimberg SV. Etiology and management of breast pain. In: Bland KI, Copeland EM, eds. The breast: comprehensive management of benign and malignant diseases. 4th ed. Philadelphia, PA: Saunders Elsevier, 2009; p. 87–96, 123–8.
34. Kullberg C, Selander J, Albin M. Female white-collar workers remain at higher risk of breast cancer after adjustments for individual risk factors related to reproduction and lifestyle. Occup Environ Med 2017; 4. pii: oemed-2016-104043. DOI: 10.1136/oemed-2016-104043.
35. Davies EL, Gateley CA, Miers M, Mansel RE. The long-term course of mastalgia. J R Soc Med 1998; 91 (9): 462–4.
36. Wisbey JR, Kumar S, Mansel RE et al. Natural history of breast pain. Lancet 1983; 2 (8351): 672–4.
37. Onstad M, Stuckey A. Benign breast disorders. Obstet Gynecol Clin North Am 2013; 40 (3): 459–73.
38. Ader DN, Shriver CD, Browne MW. Cyclical mastalgia: premenstrual syndrome or recurrent pain disorder? J Psychosom Obstet Gynaecol 1999; 20 (4): 198–202.
39. Wetzig NR. Mastalgia: a 3 year Australian study. Aust N Z J Surg 1994; 64 (5): 329–31.
40. Morrow M. Management of common breast disorders: breast pain. In: Harris JR, ed. Breast diseases. 2nd ed.Philadelphia: Lippincott, 1991; p. 63–71.
41. Plu-Bureau G, Le MG, Sitruk-Ware R, Thalabard JC. Cyclical mastalgia and breast cancer risk: results of a French cohort study. Cancer Epidemiol Biomarkers Prev 2006; 15 (6): 1229–31.
42. Smallwood JA, Kye DA, Taylor I. Mastalgia; is this commonly associated with operable breast cancer? Ann R Coll Surg Engl 1986; 68 (5): 262–3.
43. Khan SA, Apkarian AV. Mastalgia and breast cancer: a protective association? Cancer Detect Prev 2002; 26 (3): 192–6.
44. Duijm LE, Guit GL, Hendriks JH et al. Value of breast imaging in women with painful breasts:observational follow up study. BMJ 1998; 317 (7171): 1492–5.
45. Fariselli G, Lepera P, Viganotti G et al. Localized mastalgia as presenting symptom in breast cancer. Eur J Surg Oncol 1988; 14 (3): 213–5.
46. Philip J, Wijesinghe DP, Harris WG, Rustage JH. Importance of mastalgia in operable breast cancer. Br Med J (Clin Res Ed) 1982; 285 (6334): 58.
47. Preece PE, Baum M, Mansel RE et al. Importance of mastalgia in operable breast cancer. Br Med J (Clin Res Ed) 1982; 284 (6325): 1299–300.
48. Chiedozie LC, Guirguis MN. Mastalgia and breast tumour in Nigerian women. West Afr J Med 1990; 9 (1): 54–8.
49. McClenathan JH, de la Roza G. Adenoid cystic breast cancer. Am J Surg 2002; 183 (6): 646–9.
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А.Э.Протасова*1,2, Е.Н.Вандеева1

1. ФГБУ «Северо-Западный федеральный медицинский исследовательский центр им. В.А.Алмазова» Минздрава России. 197341, Россия, Санкт-Петербург, ул. Аккуратова, д. 2;
2. ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И.Мечникова» Минздрава России. 191015, Россия, Санкт-Петербург, ул. Кирочная, д. 41
*protasova1966@yandex.ru

________________________________________________

A.E.Protasova*1,2, E.N.Vandeeva1

1. V.A.Almazov North-West Federal Medical Research Center of the Ministry of Health of the Russian Federation. 197341, Russian Federation, Saint Petersburg, ul. Akkuratova, d. 2;
2. I.I.Mechnikov State Northwestern Medical University of the Ministry of Health of the Russian Federation. 191015, Russian Federation, Saint Petersburg, ul. Kirochnaia, d. 41
*protasova1966@yandex.ru