Современное состояние проблемы привычной потери беременности: дискуссионные вопросы причин и факторов риска, тактика периконцепционного ведения

1. Акушерство: национальное руководство. Под ред. Э.К.Айламазяна, В.И.Кулакова, В.Е.Радзинского, Г.М.Савельевой. М.: ГЭОТАР-Медиа, 2014. / Akusherstvo: natsional'noe rukovodstvo. Pod red. E.K.Ailamaziana, V.I.Kulakova, V.E.Radzinskogo, G.M.Savel'evoi. M.: GEOTAR-Media, 2014. [in Russian]
2. Royal College of Obstetricians and Gynaecologists. The Investigation and Treatment of Couples with Recurrent First-trimester and Second-trimester Miscarriage. Green-top Guideline №17. 2011. Apr. Available from: http://www.rcog.org.uk/globalassets/ documents/ guidelines/gtg_17.pdf
3. WHO Library Cataloguing in Publication. Good clinical diagnostic practice: a guide for clinicians in developing countries to the clinical diagnosis of disease and to making proper use of clinical diagnostic services. By Jane Carter et al. WHO Regional Publications, Eastern Mediterranean Series, 27).
4. Management of pregnancy, childbirth and the postpartum period in the presence of female genital mutilation Department of Gender, Women and Health Department of Reproductive Health and Research Family and Community Health World Health Organization 2001 from: htpp://www.who.intentitygenderother_healthmanageofpregnan.pdf
5. Practice Committee of American Society for Reproductive Medicine. Definitions of infertility and recurrent pregnancy loss: a committee opinion. Fertil Steril 2013; 99 (1): 63. PMID: 23095139.
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9. National Institute for Health and Clinical Excellence. Ectopic pregnancy and miscarriage: diagnosis and initial management in early pregnancy of ectopic pregnancy and miscarriage. NICE Clinical Guideline 154. Manchester (UK): NICE, 2012. htpp://www.nice.org.uk/ guidance/cg154/resources/guidance-ectopis-pregnancy-and-miscarriage-pdf
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12. Tunç E, Demirhan O, Demir C, Tastemir D. Cytogenetic study of recurrent miscarriages and their parents. Genetika 2007; 43 (4): 545–52. PMID: 17555132.
13. Suzumori N, Sugiura-Ogasawara M. Genetic factors as a cause of miscarriage. Curr Med Chem 2010; 17 (29): 3431–7. PMID: 20712563.
14. Kedar P, Warang P, Ghosh K. Recessive congenital mrthemoglobinemia due to NADH-cytochrome b5 reductase deficiency associated with recurrent early pregnancy loss (REPL) in an Indian family. Ann Hematol 2012; 91: 1985–6.
15. Argov Z, de Visser M. What we do know about pregnancy in hereditary neuromuscular disorders. Neuromuscul Disord 2009; 19: 675–9.
16. Carvalho B, Dória S, Ramalhob C et al. Aneuploidies detection inmiscarriages and fetal deaths using multiplex ligation-depentent probeamplification: an alternative for speeding up results? Eur J Obstet Gynecol Reprod Biol 2010; 153: 151–5.
17. Kwinecka-Dmitriew B, Zakrzewska M, Latos-Bieleńska A et al. Częst ość wystę powania aberracji chromosomowych w materiale z poronień. Ginekol Pol 2010; 81: 896–901.
18. Berghella V. Early pregnancy loss: in book Obstetric Evidence Based Guidelines. 2nd ed. 2012; p. 142–9.
19. Reid SM, Middleton P, Cossich MC et al. Interventions for clinical and subclinical hypothyroidism pre-pregnancy and during pregnancy. Cochrane Database of Systematic Reviews 2013. Issue 5. Art. No.: CD007752. DOI: 10.1002/14651858.CD007752.pub3.
20. Эндокринология. Российские клинические рекомендации. Под ред. И.И.Дедова, Г.А.Мельниченко. М.: ГЭОТАР-Медиа, 2016. / Endokrinologiia. Rossiiskie klinicheskie rekomendatsii. Pod red. I.I.Dedova, G.A.Mel'nichenko. M.: GEOTAR-Media, 2016. [in Russian]
21. Benhadi N, Wiersinga WM, Reitsma JB et al. Higher maternal TSH levels in pregnancy are associated with increased risk for miscarriage, fetal or neonatal death. Eur J Endocrinol 2009; 160: 985–91. PMID: 19273570.
22. Hengxi Chen, Jing Fu, Wei Huang. Dopamine agonists for preventing future miscarriage in women with idiopathic hyperprolactinemia and recurrent miscarriage history. Cochrane Pregnancy and Childbirth Group from: http:// onlinelibrary.wiley.com/ doi/10.1002/14651858. CD008883.pub2/full. DOI: 10.1002/14651858.CD008883.pub2.
23. Melmed F et al. Diagnosis and Treatment of Hyperprolactinemia: An Endocrine Society Clinical Practice Guideline JCEM, 2013. PMID: 21296991.
24. Алгоритмы специализированной медицинской помощи больным сахарным диабетом. Клинические рекомендации. 7-й вып. Под ред. И.И.Дедова, М.В.Шестаковой. Сахарный диабет. 2015; 18 (1S): 1–112. / Algoritmy spetsializirovannoi meditsinskoi pomoshchi bol'nym sakharnym diabetom. Klinicheskie rekomendatsii. 7-i vyp. Pod red. I.I.Dedova, M.V.Shestakovoi. Sakharnyi diabet. 2015; 18 (1S): 1–112. [in Russian]
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26. Gutaj P, Zawiejska A, Wender-Ożegowska E et al. Maternal factors predictive of first trimester pregnancy loss in women with pregestational diabetes. Pol Arch Med Wewn 2013; 123: 21–8. PMID: 23302725.
27. Furber CM, McGowan L, Bower P et al. Antenatal interventions for reducing weight in obese women for improving pregnancy outcome. Cochrane Database of Systematic Reviews 2013. Issue 1. CD009334. DOI: 10.1002/14651858.CD009334.pub2.
28. Opray N, Grivell RM, Deussen AR, Dodd JM. Directed preconception health programs and interventions for improving pregnancy outcomes for women who are overweight or obese. Cochrane Database of Systematic Reviews 2015. Issue 7. CD010932. DOI: 10.1002/14651858.CD010932.pub2.
29. Franik S, Kremer JAM, Nelen WLDM, Farquhar C. Aromatase inhibitors for subfertile women with polycystic ovary syndrome. Cochrane Database of Systematic Reviews 2014. Issue 2. CD010287. DOI: 10.1002/14651858.CD010287.pub2.
30. Sinawat S, Buppasiri P, Lumbiganon P, Pattanittum P. Long versus short course treatment withmetformin and clomiphene citrate for ovulation induction in women with PCOS. Cochrane Database of Systematic Reviews 2012. Issue 10. CD006226. DOI: 10.1002/14651858.CD006226.pub3.
31. Van der Linden M, BuckinghamK, Farquhar C et al. Luteal phase support for assisted reproduction cycles. Cochrane Database of Systematic Reviews 2015. Issue 7. CD009154. DOI: 10.1002/14651858.CD009154.pub3.
32. The Practice Committee of the American Society for Reproductive Medicine Evaluation and Treatment of Recurrent Pregnancy Loss A Committee Opinion. Fertil Steril 2012; 98: 1103–11. Issue 5.
33. Carp H. A systematic review of dydrogesterone for the treatment of recurrence miscarriage. http://informahealthcare.com/gye. DOI: 10.3109/09513590.2015.1006618.
34. Investigation and treatment of couples with recurrent miscarriage – clinical guideline. Royal Cornwall hospitals. http://www.rcht.nhs.uk/Documents Library/RoyalCornwall HospitalsTrust /Clinical/Gynaecology/InvestigationAndTreatmentOfCouplesWithRecurrentMiscarraigeJune 2014.pdf
35. Alijotas-Reig J, Garrido-Gimenez C. Current concepts and new trends in the diagnosis and management of recurrent miscarriage. Obstet Gynecol Surv 2013; 68 (6): 445–66. https://www.ncbi.nlm.nih.gov/pubmed/23942472
36. Miyakis S, Lockshin MD, Atsumi T et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 2006; 4 (2): 295–306. PMID: 16420554.
37. Empson MB, Lassere M, Craig JC, Scott JR. Prevention of recurrent miscarriage for women with antiphospholipid antibody or lupus anticoagulant. Cochrane Pregnancy and Childbirth Group. DOI: 10.1002/14651858.CD002859.pub2.
38. Ziakas PD, Pavlou M, Voulgarelis M. Heparin treatment in antiphospholipid syndrome with recurrent pregnancy loss: A systematic review and meta-analysis. Obstet Gynecol 2010; 115: 1256–62. PMID: 20502298.
39. De Jong PG, Kaandorp S, di Nisio M et al. Aspirin and/or heparin for women with unexplained recurrent miscarriage with or without inherited thrombophilia. Cochrane Database of Systematic Reviews 2014. Issue 7. CD004734. DOI: 10.1002/14651858. CD004734.pub4.
40. ACOG, WHCP, ACOG Practice Bulletin №138: Inherited thrombophilias in pregnancy. Obstet Gynecol 2013; 122 (3): 706–17. PMID: 23963422.
41. Virkus RA, Lökkegaard E, Lidegaard Ŏ et al. Risk Factors for Venous Thromboembolism in 1,3 Million Pregnancies: A Nationwide Prospective Cohort. PLoS ONE 2014; 9 (5): e96495. PMID: 24788753.
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54. Прилепская В.Н., Кутуева Ф.Р., Кулешов В.М. и др. Результаты Российской неинтервенционной (наблюдательной) программы по назначению витаминно-минерального комплекса для профилактики гиповитаминозов и дефицита минеральных веществ ПРОГНОСТИК у беременных женщин. Гинекология. 2016; 18 (4): 5–12. / Prilepskaia V.N., Kutueva F.R., Kuleshov V.M. i dr. Rezul'taty Rossiiskoi neinterventsionnoi (nabliudatel'noi) programmy po naznacheniiu vitaminno-mineral'nogo kompleksa dlia profilaktiki gipovitaminozov i defitsita mineral'nykh veshchestv PROGNOSTIK u beremennykh zhenshchin. Ginekologiia. 2016; 18 (4): 5–12. [in Russian]
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58. Mori M, Bogdan A, Balassa T et al. The deciduas – the maternal bed embracing the embryo-maintains the pregnancy. Semin Immunopathol 2016; 38: 635–49. DOI 10.1007/s00281-016-0574-0.
59. Wong LF, Porter TF, Scott JR. Immunotherapy for recurrent miscarriage. Cochrane Database of Systematic Reviews 2014. Issue 10. CD000112. DOI: 10.1002/ 14651858.CD000112. pub3.
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1. Akusherstvo: natsional'noe rukovodstvo. Pod red. E.K.Ailamaziana, V.I.Kulakova, V.E.Radzinskogo, G.M.Savel'evoi. M.: GEOTAR-Media, 2014. [in Russian]
2. Royal College of Obstetricians and Gynaecologists. The Investigation and Treatment of Couples with Recurrent First-trimester and Second-trimester Miscarriage. Green-top Guideline №17. 2011. Apr. Available from: http://www.rcog.org.uk/globalassets/ documents/ guidelines/gtg_17.pdf
3. WHO Library Cataloguing in Publication. Good clinical diagnostic practice: a guide for clinicians in developing countries to the clinical diagnosis of disease and to making proper use of clinical diagnostic services. By Jane Carter et al. WHO Regional Publications, Eastern Mediterranean Series, 27).
4. Management of pregnancy, childbirth and the postpartum period in the presence of female genital mutilation Department of Gender, Women and Health Department of Reproductive Health and Research Family and Community Health World Health Organization 2001 from: htpp://www.who.intentitygenderother_healthmanageofpregnan.pdf
5. Practice Committee of American Society for Reproductive Medicine. Definitions of infertility and recurrent pregnancy loss: a committee opinion. Fertil Steril 2013; 99 (1): 63. PMID: 23095139.
6. Sidel'nikova V.M., Sukhikh G.T. Nevynashivanie beremennosti. Rukovodstvo dlia praktikuiushchikh vrachei. M.: MIA; 2010. [in Russian]
7. Klinicheskie rekomendatsii (protokol lecheniia). Vykidysh v rannie sroki beremennosti: diagnostika i taktika vedeniia, 2016 god. htpp://mz.mosreg.ru/upload/iblock /vykydish-v-rannie-sroki-beremennosti-diagnostika-i-taktika-vedenya.pdf [in Russian]
8. Pregravidarnaia podgotovka: klinicheskii protokol. Avt.-razrab. V.E.Radzinskii i dr. M.: StatusPraesens, 2016. (Utverzhden Protokolom №4P-16 Prezidiuma Pravleniia Mezhdistsiplinarnoi assotsiatsii spetsialistov reproduktivnoi meditsiny – MARS ot 28.06.2016, Moskva). https://praesens.ru/pregravidarnaya-podgotovka-klinicheskiy-protokol-mezhdistsiplinarnoy-assotsiatsi... [in Russian]
9. National Institute for Health and Clinical Excellence. Ectopic pregnancy and miscarriage: diagnosis and initial management in early pregnancy of ectopic pregnancy and miscarriage. NICE Clinical Guideline 154. Manchester (UK): NICE, 2012. htpp://www.nice.org.uk/ guidance/cg154/resources/guidance-ectopis-pregnancy-and-miscarriage-pdf
10. Savel'eva G.M., Shalina R.I., Sichinava L.G. i dr. Akusherstvo. Uchebnik dlia vuzov. M., 2009. [in Russian]
11. Stephenson MD, Awartani KA, Robinson WP. Cytogenetic analysis of miscarriages from couples with recurrent miscagiage: a case-control study. Hum Reprod 2002; 17 (2): 446–51.
12. Tunç E, Demirhan O, Demir C, Tastemir D. Cytogenetic study of recurrent miscarriages and their parents. Genetika 2007; 43 (4): 545–52. PMID: 17555132.
13. Suzumori N, Sugiura-Ogasawara M. Genetic factors as a cause of miscarriage. Curr Med Chem 2010; 17 (29): 3431–7. PMID: 20712563.
14. Kedar P, Warang P, Ghosh K. Recessive congenital mrthemoglobinemia due to NADH-cytochrome b5 reductase deficiency associated with recurrent early pregnancy loss (REPL) in an Indian family. Ann Hematol 2012; 91: 1985–6.
15. Argov Z, de Visser M. What we do know about pregnancy in hereditary neuromuscular disorders. Neuromuscul Disord 2009; 19: 675–9.
16. Carvalho B, Dória S, Ramalhob C et al. Aneuploidies detection inmiscarriages and fetal deaths using multiplex ligation-depentent probeamplification: an alternative for speeding up results? Eur J Obstet Gynecol Reprod Biol 2010; 153: 151–5.
17. Kwinecka-Dmitriew B, Zakrzewska M, Latos-Bieleńska A et al. Częst ość wystę powania aberracji chromosomowych w materiale z poronień. Ginekol Pol 2010; 81: 896–901.
18. Berghella V. Early pregnancy loss: in book Obstetric Evidence Based Guidelines. 2nd ed. 2012; p. 142–9.
19. Reid SM, Middleton P, Cossich MC et al. Interventions for clinical and subclinical hypothyroidism pre-pregnancy and during pregnancy. Cochrane Database of Systematic Reviews 2013. Issue 5. Art. No.: CD007752. DOI: 10.1002/14651858.CD007752.pub3.
20. Endokrinologiia. Rossiiskie klinicheskie rekomendatsii. Pod red. I.I.Dedova, G.A.Mel'nichenko. M.: GEOTAR-Media, 2016. [in Russian]
21. Benhadi N, Wiersinga WM, Reitsma JB et al. Higher maternal TSH levels in pregnancy are associated with increased risk for miscarriage, fetal or neonatal death. Eur J Endocrinol 2009; 160: 985–91. PMID: 19273570.
22. Hengxi Chen, Jing Fu, Wei Huang. Dopamine agonists for preventing future miscarriage in women with idiopathic hyperprolactinemia and recurrent miscarriage history. Cochrane Pregnancy and Childbirth Group from: http:// onlinelibrary.wiley.com/ doi/10.1002/14651858. CD008883.pub2/full. DOI: 10.1002/14651858.CD008883.pub2.
23. Melmed F et al. Diagnosis and Treatment of Hyperprolactinemia: An Endocrine Society Clinical Practice Guideline JCEM, 2013. PMID: 21296991.
24. Algoritmy spetsializirovannoi meditsinskoi pomoshchi bol'nym sakharnym diabetom. Klinicheskie rekomendatsii. 7-i vyp. Pod red. I.I.Dedova, M.V.Shestakovoi. Sakharnyi diabet. 2015; 18 (1S): 1–112. [in Russian]
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М.Ю.Скворцова*, С.Г.Прилуцкая

ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России. 125993, Россия, Москва, ул. Баррикадная, д. 2/1
*margodus@mail.ru

________________________________________________

M.Yu.Skvortsova*, S.G.Prilutskaia

Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation. 125993, Russian Federation, Moscow, ul. Barrikadnaia, d. 2/1
*margodus@mail.ru