В статье обобщены результаты многочисленных рандомизированных исследований и структурирован подход к тактике ведения пациенток с первичной дисменореей. Стартовой терапией является назначение нестероидных противовоспалительных средств и/или эстроген-гестагенных препаратов. При отсутствии эффекта от терапии в течение 3 мес целесообразно перейти на препарат другой группы или комбинацию лекарств. Недостижение желаемого терапевтического результата в течение 6 мес является основанием для уточнения диагноза. Статья проиллюстрирована клиническим случаем ведения пациентки с первичной дисменореей.
The article summarizes the results of numerous randomized studies and structured the approach to the tactics of managing patients with primary dysmenorrhea. The starting therapy is the administration of non-steroidal anti-inflammatory drugs and/or estrogen-progestational drugs. In the absence of the effect of therapy for 3 months, it is advisable to switch to a drug of another group or a combination of drugs. Failure to achieve the desired therapeutic result within 6 months is the basis for clarifying the diagnosis. The article is illustrated by the clinical case of a patient with primary dysmenorrhea.
1. Majoribanks J, Proctor M, Farquhar C et al. Nonsteroidal anti-inflammatory drugs for dysmenorrhoea (review). Cochrane Database Systematic Rev 2010; 20: 1.
2. Norman RJ. Reproductive consequences of COX-2 inhibition. Lancet 2001; 358: 1287.
3. Norman RJ, Wu R. The potential danger of COX-2 inhibitors. Fertil Steril 2004; 81: 493.
4. Andersch B, Milsom I. An epidemiologic study of young women with dysmenorrhea. Am J Obstet Gynecol 1982; 144: 655.
5. Fedele L, Marchini M, Acaia B et al. Dynamics and significance of placebo response in primary dysmenorrhea. Pain 1989; 36: 43.
6. Missmer SA, Hankinson SE, Spiegelman D et al. Incidence of laparoscopically confirmed endometriosis by demographic, anthropometric, and lifestyle factors. Am J Epidemiol 2004; 160: 784.
7. Marjoribanks J, Proctor M, Farquhar C, Derks RS. Nonsteroidal anti-inflammatory drugs for dysmenorrhoea. Cochrane Database Syst Rev 2010; CD001751.
8. Zahradnik HP, Hanjalic-Beck A, Groth K. Nonsteroidal anti-inflammatory drugs and hormonal contraceptives for pain relief from dysmenorrhea: a review. Contraception 2010; 81: 185.
9. Wong CL, Farquhar C, Roberts H, Proctor M. Oral contraceptive pill for primary dysmenorrhoea. Cochrane Database Syst Rev 2009; CD002120.
10. Petraglia F, Parke S, Serrani M et al. Estradiol valerate plus dienogest versus ethinylestradiol plus levonorgestrel for the treatment of primary dysmenorrhea. Int J Gynaecol Obstet 2014; 125: 270.
11. Davis AR, Westhoff C, O'Connell K, Gallagher N. Oral contraceptives for dysmenorrhea in adolescent girls: a randomized trial. Obstet Gynecol 2005; 106: 97.
12. Machado RB, de Melo NR, Maia H Jr. Bleeding patterns and menstrual-related symptoms with the continuous use of a contraceptive combination of ethinylestradiol and drospirenone: a randomized study. Contraception 2010; 81: 215.
13. Roumen FJ. The contraceptive vaginal ring compared with the combined oral contraceptive pill: a comprehensive review of randomized controlled trials. Contraception 2007; 75: 420.
14. Lindh I, Milsom I. The influence of intrauterine contraception on the prevalence and severity of dysmenorrhea: a longitudinal population study. Hum Reprod 2013; 28: 1953.
15. Walch K, Unfried G, Huber J et al. Implanon versus medroxyprogesterone acetate: effects on pain scores in patients with symptomatic endometriosis – a pilot study. Contraception 2009; 79: 29.
16. Morgan PJ, Kung R, Tarshis J. Nitroglycerin as a uterine relaxant: a systematic review. J Obstet Gynaecol Can 2002; 24: 403.
17. Proctor ML, Murphy PA. Herbal and dietary therapies for primary and secondary dysmenorrhoea. Cochrane Database Syst Rev 2001; CD002124.
18. Pattanittum P, Kunyanone N, Brown J et al. Dietary supplements for dysmenorrhoea. Cochrane Database Syst Rev 2016; 3: CD002124.
19. Barnard ND, Scialli AR, Hurlock D, Bertron P. Diet and sex-hormone binding globulin, dysmenorrhea, and premenstrual symptoms. Obstet Gynecol 2000; 95: 245.
20. Abdul-Razzak KK, Ayoub NM, Abu-Taleb AA, Obeidat BA. Influence of dietary intake of dairy products on dysmenorrhea. J Obstet Gynaecol Res 2010; 36: 377.
21. Akin M, Price W, Rodriguez G Jr et al. Continuous, low-level, topical heat wrap therapy as compared to acetaminophen for primary dysmenorrhea. J Reprod Med 2004; 49: 739.
22. Lee B, Hong SH, Kim K, et al. Efficacy of the device combining high-frequency transcutaneous electrical nerve stimulation and thermotherapy for relieving primary dysmenorrhea: a randomized, single-blind, placebo-controlled trial. Eur J Obstet Gynecol Reprod Biol 2015; 194: 58.
23. Golomb LM, Solidum AA, Warren MP. Primary dysmenorrhea and physical activity. Med Sci Sports Exerc 1998; 30: 906.
24. Brown J, Brown S. Exercise for dysmenorrhoea. Cochrane Database Syst Rev 2010; CD004142.
25. Yang NY, Kim SD. Effects of a Yoga Program on Menstrual Cramps and Menstrual Distress in Undergraduate Students with Primary Dysmenorrhea: A Single-Blind, Randomized Controlled Trial. J Altern Complement Med 2016; 22: 732.
26. Hatcher RA. Counseling couples about coitus during menstrual flow. Contracept Technol Update 1981; 2: 167.
27. Ziaei S, Zakeri M, Kazemnejad A. A randomised controlled trial of vitamin E in the treatment of primary dysmenorrhoea. BJOG 2005; 112: 466.
28. Daily JW, Zhang X, Kim DS, Park S. Efficacy of Ginger for Alleviating the Symptoms of Primary Dysmenorrhea: A Systematic Review and Meta-analysis of Randomized Clinical Trials. Pain Med 2015; 16: 2243.
29. Smith CA, Armour M, Zhu X, et al. Acupuncture for dysmenorrhoea. Cochrane Database Syst Rev 2016; 4: CD007854.
30. Zhu X, Proctor M, Bensoussan A et al. Chinese herbal medicine for primary dysmenorrhoea. Cochrane Database Syst Rev 2007; CD005288.
________________________________________________
1. Majoribanks J, Proctor M, Farquhar C et al. Nonsteroidal anti-inflammatory drugs for dysmenorrhoea (review). Cochrane Database Systematic Rev 2010; 20: 1.
2. Norman RJ. Reproductive consequences of COX-2 inhibition. Lancet 2001; 358: 1287.
3. Norman RJ, Wu R. The potential danger of COX-2 inhibitors. Fertil Steril 2004; 81: 493.
4. Andersch B, Milsom I. An epidemiologic study of young women with dysmenorrhea. Am J Obstet Gynecol 1982; 144: 655.
5. Fedele L, Marchini M, Acaia B et al. Dynamics and significance of placebo response in primary dysmenorrhea. Pain 1989; 36: 43.
6. Missmer SA, Hankinson SE, Spiegelman D et al. Incidence of laparoscopically confirmed endometriosis by demographic, anthropometric, and lifestyle factors. Am J Epidemiol 2004; 160: 784.
7. Marjoribanks J, Proctor M, Farquhar C, Derks RS. Nonsteroidal anti-inflammatory drugs for dysmenorrhoea. Cochrane Database Syst Rev 2010; CD001751.
8. Zahradnik HP, Hanjalic-Beck A, Groth K. Nonsteroidal anti-inflammatory drugs and hormonal contraceptives for pain relief from dysmenorrhea: a review. Contraception 2010; 81: 185.
9. Wong CL, Farquhar C, Roberts H, Proctor M. Oral contraceptive pill for primary dysmenorrhoea. Cochrane Database Syst Rev 2009; CD002120.
10. Petraglia F, Parke S, Serrani M et al. Estradiol valerate plus dienogest versus ethinylestradiol plus levonorgestrel for the treatment of primary dysmenorrhea. Int J Gynaecol Obstet 2014; 125: 270.
11. Davis AR, Westhoff C, O'Connell K, Gallagher N. Oral contraceptives for dysmenorrhea in adolescent girls: a randomized trial. Obstet Gynecol 2005; 106: 97.
12. Machado RB, de Melo NR, Maia H Jr. Bleeding patterns and menstrual-related symptoms with the continuous use of a contraceptive combination of ethinylestradiol and drospirenone: a randomized study. Contraception 2010; 81: 215.
13. Roumen FJ. The contraceptive vaginal ring compared with the combined oral contraceptive pill: a comprehensive review of randomized controlled trials. Contraception 2007; 75: 420.
14. Lindh I, Milsom I. The influence of intrauterine contraception on the prevalence and severity of dysmenorrhea: a longitudinal population study. Hum Reprod 2013; 28: 1953.
15. Walch K, Unfried G, Huber J et al. Implanon versus medroxyprogesterone acetate: effects on pain scores in patients with symptomatic endometriosis – a pilot study. Contraception 2009; 79: 29.
16. Morgan PJ, Kung R, Tarshis J. Nitroglycerin as a uterine relaxant: a systematic review. J Obstet Gynaecol Can 2002; 24: 403.
17. Proctor ML, Murphy PA. Herbal and dietary therapies for primary and secondary dysmenorrhoea. Cochrane Database Syst Rev 2001; CD002124.
18. Pattanittum P, Kunyanone N, Brown J et al. Dietary supplements for dysmenorrhoea. Cochrane Database Syst Rev 2016; 3: CD002124.
19. Barnard ND, Scialli AR, Hurlock D, Bertron P. Diet and sex-hormone binding globulin, dysmenorrhea, and premenstrual symptoms. Obstet Gynecol 2000; 95: 245.
20. Abdul-Razzak KK, Ayoub NM, Abu-Taleb AA, Obeidat BA. Influence of dietary intake of dairy products on dysmenorrhea. J Obstet Gynaecol Res 2010; 36: 377.
21. Akin M, Price W, Rodriguez G Jr et al. Continuous, low-level, topical heat wrap therapy as compared to acetaminophen for primary dysmenorrhea. J Reprod Med 2004; 49: 739.
22. Lee B, Hong SH, Kim K, et al. Efficacy of the device combining high-frequency transcutaneous electrical nerve stimulation and thermotherapy for relieving primary dysmenorrhea: a randomized, single-blind, placebo-controlled trial. Eur J Obstet Gynecol Reprod Biol 2015; 194: 58.
23. Golomb LM, Solidum AA, Warren MP. Primary dysmenorrhea and physical activity. Med Sci Sports Exerc 1998; 30: 906.
24. Brown J, Brown S. Exercise for dysmenorrhoea. Cochrane Database Syst Rev 2010; CD004142.
25. Yang NY, Kim SD. Effects of a Yoga Program on Menstrual Cramps and Menstrual Distress in Undergraduate Students with Primary Dysmenorrhea: A Single-Blind, Randomized Controlled Trial. J Altern Complement Med 2016; 22: 732.
26. Hatcher RA. Counseling couples about coitus during menstrual flow. Contracept Technol Update 1981; 2: 167.
27. Ziaei S, Zakeri M, Kazemnejad A. A randomised controlled trial of vitamin E in the treatment of primary dysmenorrhoea. BJOG 2005; 112: 466.
28. Daily JW, Zhang X, Kim DS, Park S. Efficacy of Ginger for Alleviating the Symptoms of Primary Dysmenorrhea: A Systematic Review and Meta-analysis of Randomized Clinical Trials. Pain Med 2015; 16: 2243.
29. Smith CA, Armour M, Zhu X, et al. Acupuncture for dysmenorrhoea. Cochrane Database Syst Rev 2016; 4: CD007854.
30. Zhu X, Proctor M, Bensoussan A et al. Chinese herbal medicine for primary dysmenorrhoea. Cochrane Database Syst Rev 2007; CD005288.
Авторы
Ю.Э.Доброхотова, Е.И.Боровкова*, С.А.Залесская
ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И.Пирогова» Минздрава России. 117997, Россия, Москва, ул. Островитянова, д.1
*katyanikitina@mail.ru
________________________________________________
Yu.E.Dobrokhotova, E.I.Borovkova*, S.A.Zalesskaia
N.I.Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Ostrovitianova, d. 1
*katyanikitina@mail.ru