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Витамин D и эстрогензависимые опухоли
Громова О.А., Торшин И.Ю., Фролова Д.Е. и др. Витамин D и эстрогензависимые опухоли. Гинекология. 2018; 20 (1): 23–30.
DOI: 10.26442/2079-5696_20.1.23-30
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Gromova O.A., Torshin I.Iu., Frolova D.E. et al. Vitamin D and estrogen-dependent tumors. Gynecology. 2018; 20 (1): 23–30. DOI: 10.26442/2079-5696_20.1.23-30
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Аннотация
Витамин D характеризуется неоспоримыми противоопухолевыми свойствами, которые важны как для профилактики, так и для терапии опухолевых заболеваний. В работе представлены результаты систематического анализа молекулярных механизмов противоопухолевых эффектов витамина D (ингибирование каскада Wnt/b-катенина, фактора транскрипции WSTF) и результаты клинических исследований пациентов с эстрогензависимыми опухолями, указывающие на перспективность сочетанного применения препаратов эстрогенов и витамина D.
Ключевые слова: эстрогены, витамин D, рак молочной железы, рак толстого кишечника, менопаузальная гормональная терапия, Аквадетрим.
Ключевые слова: эстрогены, витамин D, рак молочной железы, рак толстого кишечника, менопаузальная гормональная терапия, Аквадетрим.
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Vitamin D is characterized by undeniable antitumor properties that are important for both prevention and treatment of tumor diseases. The results of a systematic analysis of the molecular mechanisms of antitumor effects of vitamin D (inhibition of the Wnt/b-catenin cascade, the transcription factor WSTF) and the results of clinical studies of patients with estrogen-dependent tumors are presented, indicating the promise of combined use of estrogen and vitamin D.
Key words: estrogens, vitamin D, breast cancer, colon cancer, menopausal hormone therapy, Aquadetrim.
Полный текст
Список литературы
1. Громова О.А., Торшин И.Ю., Лиманова О.А. и др. Сравнительное исследование доказательной базы эффективности и безопасности применения пероральной и трансдермальной форм заместительной гормональной терапии эстрогенами у женщин в различные возрастные периоды. Пробл. репродукции. 2013; 6: 86–96. / Gromova O.A., Torshin I.Iu., Limanova O.A. i dr. Sravnitel'noe issledovanie dokazatel'noi bazy effektivnosti i bezopasnosti primeneniia peroral'noi i transdermal'noi form zamestitel'noi gormonal'noi terapii estrogenami u zhenshchin v razlichnye vozrastnye periody. Probl. reproduktsii. 2013; 6: 86–96. [in Russian]
2. Лапочкина Н.П. Гормональный статус женщин с заболеваниями молочных желез. Вестн. РНЦ рентгенорадиологии Минздрава России (электронная версия). 2006; 6. / Lapochkina N.P. Gormonal'nyi status zhenshchin s zabolevaniiami molochnykh zhelez. Vestn. RNTs rentgenoradiologii Minzdrava Rossii (elektronnaia versiia). 2006; 6. [in Russian]
3. Wang K, Li F, Chen L et al. Change in risk of breast cancer after receiving hormone replacement therapy by considering effect-modifiers: a systematic review and dose-response meta-analysis of prospective studies. Oncotarget 2017; 8 (46): 81109–24. DOI: 10.18632/oncotarget.20154
4. Heiss G, Wallace R, Anderson GL et al. Health risks and benefits 3 years after stopping randomized treatment with estrogen and progestin. JAMA 2008; 299 (9): 1036–45.
5. Ettinger B, Wang SM, Leslie RS et al. Evolution of postmenopausal hormone therapy between 2002 and 2009. Menopause 2012; 19 (6): 610–5.
6. Громова О.А., Торшин И.Ю., Филимонова М.В. Роль витаминов в профилактике рака и эффективности противоопухолевой терапии: систематический анализ доказательных исследований. Терапия. 2018; 2: 65–74. / Gromova O.A., Torshin I.Iu., Filimonova M.V. Rol' vitaminov v profilaktike raka i effektivnosti protivoopukholevoi terapii: sistematicheskii analiz dokazatel'nykh issledovanii. Terapiia. 2018; 2: 65–74. [in Russian]
7. Громова О.А., Торшин И.Ю., Учайкин В.Ф., Лиманова О.А. Роль витамина D в поддержании противотуберкулезного, антивирусного и общего противоинфекционного иммунитета. Инфекционные болезни. 2014; 4: 65–74. / Gromova O.A., Torshin I.Iu., Uchaikin V.F., Limanova O.A. Rol' vitamina D v podderzhanii protivotuberkuleznogo, antivirusnogo i obshchego protivoinfektsionnogo immuniteta. Infektsionnye bolezni. 2014; 4: 65–74. [in Russian]
8. Громова О.А., Торшин И.Ю. Витамин D. Смена парадигмы. Под ред. Е.И.Гусева, И.Н.Захаровой. М.: ГЭОТАР-Медиа, 2017. / Gromova O.A., Torshin I.Iu. Vitamin D. Smena paradigmy. Pod red. E.I.Guseva, I.N.Zakharovoi. M.: GEOTAR-Media, 2017. [in Russian]
9. Dou R, Ng K, Giovannucci EL et al. Vitamin D and colorectal cancer: molecular, epidemiological and clinical evidence. Br J Nutr 2016; 115 (9): 1643–60.
10. Громова О.А., Пронин А.В., Гришина Т.Р. и др. Противоопухолевые эффекты аквадетрима водного раствора мицелл с витамином D. Фарматека. 2015; 20: 63–8. / Gromova O.A., Pronin A.V., Grishina T.R. i dr. Protivoopukholevye effekty akvadetrima vodnogo rastvora mitsell s vitaminom D. Farmateka. 2015; 20: 63–8. [in Russian]
11. Radujkovic A, Schnitzler P, Ho AD et al. Low serum vitamin D levels are associated with shorter survival after first-line azacitidine treatment in patients with myelodysplastic syndrome and secondary oligoblastic acute myeloid leukemia. Clin Nutr 2017; 36 (2): 542–51.
12. Chung M, Lee J, Terasawa T et al. Vitamin D with or without calcium supplementation for prevention of cancer and fractures: an updated meta-analysis for the U.S. Preventive Services Task Force. Ann Intern Med 2011; 155 (12): 827–38.
13. Ma Y, Zhang P, Wang F et al. Association between vitamin D and risk of colorectal cancer: a systematic review of prospective studies. J Clin Oncol 2011; 29 (28): 3775–82.
14. Chen P, Hu P, Xie D et al. Meta-analysis of vitamin D, calcium and the prevention of breast cancer. Breast Cancer Res Treat 2010; 121 (2): 469–77.
15. Gilad LA, Schwartz B. Association of estrogen receptor beta with plasma-membrane caveola components: implication in control of vitamin D receptor. J Mol Endocrinol 2007; 38 (6): 603.
16. Jeong Y, Swami S, Krishnan AV et al. Inhibition of Mouse Breast Tumor-Initiating Cells by Calcitriol and Dietary Vitamin D. Mol Cancer Ther 2015; 14 (8): 1951–61.
17. Lundqvist J, Kirkegaard T, Laenkholm AV et al. Williams syndrome transcription factor (WSTF) acts as an activator of estrogen receptor signaling in breast cancer cells and the effect can be abrogated by 1a,25-dihydroxyvitamin D3. J Steroid Biochem Mol Biol 2017.
18. Pizzorno L. Nothing Boring About Boron. Integr Med (Encinitas) 2015; 14 (4): 35–48.
19. De Sousa Almeida-Filho B, De Luca Vespoli H, Pessoa EC et al. Vitamin D deficiency is associated with poor breast cancer prognostic features in postmenopausal women. J Steroid Biochem Mol Biol 2017; 174: 284–9.
20. Buono G, Giuliano M, De Angelis C et al. Pretreatment Serum Concentration of Vitamin D and Breast Cancer Characteristics: A Prospective Observational Mediterranean Study. Clin Breast Cancer 2017; 17 (7): 559–563.
21. Cadeau C, Fournier A, Mesrine S et al. Interaction between current vitamin D supplementation and menopausal hormone therapy use on breast cancer risk: evidence from the E3N cohort. Am J Clin Nutr 2015; 102 (4): 966–73.
22. Wang D, Velez de-la-Paz OI, Zhai JX, Liu DW. Serum 25-hydroxyvitamin D and breast cancer risk: a meta-analysis of prospective studies. Tumour Biol 2013; 34 (6): 3509–17.
23. Bauer SR, Hankinson SE, Bertone-Johnson ER, Ding EL. Plasma vitamin D levels, menopause, and risk of breast cancer: dose-response meta-analysis of prospective studies. Medicine (Baltimore) 2013; 92 (3): 123–31.
24. Chen P, Li M, Gu X et al. Higher blood 25(OH)D level may reduce the breast cancer risk: evidence from a Chinese population based case-control study and meta-analysis of the observational studies. PLoS One 2013; 8 (1): e49312.
25. Hong Z, Tian C, Zhang X. Dietary calcium intake, vitamin D levels, and breast cancer risk: a dose-response analysis of observational studies. Breast Cancer Res Treat 2012; 136 (1): 309–12.
26. Mohr SB, Gorham ED, Alcaraz JE et al. Serum 25-hydroxyvitamin D and prevention of breast cancer: pooled analysis. Anticancer Res 2011; 31 (9): 2939–48.
27. Kim Y, Je Y. Vitamin D intake, blood 25(OH)D levels, and breast cancer risk or mortality: a meta-analysis. Br J Cancer 2014; 110 (11): 2772–84.
28. Ding EL, Mehta S, Fawzi WW, Giovannucci EL. Interaction of estrogen therapy with calcium and vitamin D supplementation on colorectal cancer risk: reanalysis of Women's Health Initiative randomized trial. Int J Cancer 2008; 122 (8): 1690–4.
29. Chung M, Lee J, Terasawa T et al. Vitamin D with or without calcium supplementation for prevention of cancer and fractures: an updated meta-analysis for the U.S. Preventive Services Task Force. Ann Intern Med 2011; 155 (12): 827–38.
30. Lee JE, Li H, Chan AT et al. Circulating levels of vitamin D and colon and rectal cancer: the Physicians' Health Study and a meta-analysis of prospective studies. Cancer Prev Res (Phila) 2011; 4 (5): 735–43.
31. Touvier M, Chan DS, Lau R, Aune D. Meta-analyses of vitamin D intake, 25-hydroxyvitamin D status, vitamin D receptor polymorphisms, and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev 2011; 20 (5): 1003–16.
32. Lagunova Z, Porojnicu AC. Obesity and increased risk of cancer: does decrease of serum 25-hydroxyvitamin D level with increasing body mass index explain some of the association? Mol Nutr Food Res 2010; 54 (8): 1127–33.
2. Лапочкина Н.П. Гормональный статус женщин с заболеваниями молочных желез. Вестн. РНЦ рентгенорадиологии Минздрава России (электронная версия). 2006; 6. / Lapochkina N.P. Gormonal'nyi status zhenshchin s zabolevaniiami molochnykh zhelez. Vestn. RNTs rentgenoradiologii Minzdrava Rossii (elektronnaia versiia). 2006; 6. [in Russian]
3. Wang K, Li F, Chen L et al. Change in risk of breast cancer after receiving hormone replacement therapy by considering effect-modifiers: a systematic review and dose-response meta-analysis of prospective studies. Oncotarget 2017; 8 (46): 81109–24. DOI: 10.18632/oncotarget.20154
4. Heiss G, Wallace R, Anderson GL et al. Health risks and benefits 3 years after stopping randomized treatment with estrogen and progestin. JAMA 2008; 299 (9): 1036–45.
5. Ettinger B, Wang SM, Leslie RS et al. Evolution of postmenopausal hormone therapy between 2002 and 2009. Menopause 2012; 19 (6): 610–5.
6. Громова О.А., Торшин И.Ю., Филимонова М.В. Роль витаминов в профилактике рака и эффективности противоопухолевой терапии: систематический анализ доказательных исследований. Терапия. 2018; 2: 65–74. / Gromova O.A., Torshin I.Iu., Filimonova M.V. Rol' vitaminov v profilaktike raka i effektivnosti protivoopukholevoi terapii: sistematicheskii analiz dokazatel'nykh issledovanii. Terapiia. 2018; 2: 65–74. [in Russian]
7. Громова О.А., Торшин И.Ю., Учайкин В.Ф., Лиманова О.А. Роль витамина D в поддержании противотуберкулезного, антивирусного и общего противоинфекционного иммунитета. Инфекционные болезни. 2014; 4: 65–74. / Gromova O.A., Torshin I.Iu., Uchaikin V.F., Limanova O.A. Rol' vitamina D v podderzhanii protivotuberkuleznogo, antivirusnogo i obshchego protivoinfektsionnogo immuniteta. Infektsionnye bolezni. 2014; 4: 65–74. [in Russian]
8. Громова О.А., Торшин И.Ю. Витамин D. Смена парадигмы. Под ред. Е.И.Гусева, И.Н.Захаровой. М.: ГЭОТАР-Медиа, 2017. / Gromova O.A., Torshin I.Iu. Vitamin D. Smena paradigmy. Pod red. E.I.Guseva, I.N.Zakharovoi. M.: GEOTAR-Media, 2017. [in Russian]
9. Dou R, Ng K, Giovannucci EL et al. Vitamin D and colorectal cancer: molecular, epidemiological and clinical evidence. Br J Nutr 2016; 115 (9): 1643–60.
10. Громова О.А., Пронин А.В., Гришина Т.Р. и др. Противоопухолевые эффекты аквадетрима водного раствора мицелл с витамином D. Фарматека. 2015; 20: 63–8. / Gromova O.A., Pronin A.V., Grishina T.R. i dr. Protivoopukholevye effekty akvadetrima vodnogo rastvora mitsell s vitaminom D. Farmateka. 2015; 20: 63–8. [in Russian]
11. Radujkovic A, Schnitzler P, Ho AD et al. Low serum vitamin D levels are associated with shorter survival after first-line azacitidine treatment in patients with myelodysplastic syndrome and secondary oligoblastic acute myeloid leukemia. Clin Nutr 2017; 36 (2): 542–51.
12. Chung M, Lee J, Terasawa T et al. Vitamin D with or without calcium supplementation for prevention of cancer and fractures: an updated meta-analysis for the U.S. Preventive Services Task Force. Ann Intern Med 2011; 155 (12): 827–38.
13. Ma Y, Zhang P, Wang F et al. Association between vitamin D and risk of colorectal cancer: a systematic review of prospective studies. J Clin Oncol 2011; 29 (28): 3775–82.
14. Chen P, Hu P, Xie D et al. Meta-analysis of vitamin D, calcium and the prevention of breast cancer. Breast Cancer Res Treat 2010; 121 (2): 469–77.
15. Gilad LA, Schwartz B. Association of estrogen receptor beta with plasma-membrane caveola components: implication in control of vitamin D receptor. J Mol Endocrinol 2007; 38 (6): 603.
16. Jeong Y, Swami S, Krishnan AV et al. Inhibition of Mouse Breast Tumor-Initiating Cells by Calcitriol and Dietary Vitamin D. Mol Cancer Ther 2015; 14 (8): 1951–61.
17. Lundqvist J, Kirkegaard T, Laenkholm AV et al. Williams syndrome transcription factor (WSTF) acts as an activator of estrogen receptor signaling in breast cancer cells and the effect can be abrogated by 1a,25-dihydroxyvitamin D3. J Steroid Biochem Mol Biol 2017.
18. Pizzorno L. Nothing Boring About Boron. Integr Med (Encinitas) 2015; 14 (4): 35–48.
19. De Sousa Almeida-Filho B, De Luca Vespoli H, Pessoa EC et al. Vitamin D deficiency is associated with poor breast cancer prognostic features in postmenopausal women. J Steroid Biochem Mol Biol 2017; 174: 284–9.
20. Buono G, Giuliano M, De Angelis C et al. Pretreatment Serum Concentration of Vitamin D and Breast Cancer Characteristics: A Prospective Observational Mediterranean Study. Clin Breast Cancer 2017; 17 (7): 559–563.
21. Cadeau C, Fournier A, Mesrine S et al. Interaction between current vitamin D supplementation and menopausal hormone therapy use on breast cancer risk: evidence from the E3N cohort. Am J Clin Nutr 2015; 102 (4): 966–73.
22. Wang D, Velez de-la-Paz OI, Zhai JX, Liu DW. Serum 25-hydroxyvitamin D and breast cancer risk: a meta-analysis of prospective studies. Tumour Biol 2013; 34 (6): 3509–17.
23. Bauer SR, Hankinson SE, Bertone-Johnson ER, Ding EL. Plasma vitamin D levels, menopause, and risk of breast cancer: dose-response meta-analysis of prospective studies. Medicine (Baltimore) 2013; 92 (3): 123–31.
24. Chen P, Li M, Gu X et al. Higher blood 25(OH)D level may reduce the breast cancer risk: evidence from a Chinese population based case-control study and meta-analysis of the observational studies. PLoS One 2013; 8 (1): e49312.
25. Hong Z, Tian C, Zhang X. Dietary calcium intake, vitamin D levels, and breast cancer risk: a dose-response analysis of observational studies. Breast Cancer Res Treat 2012; 136 (1): 309–12.
26. Mohr SB, Gorham ED, Alcaraz JE et al. Serum 25-hydroxyvitamin D and prevention of breast cancer: pooled analysis. Anticancer Res 2011; 31 (9): 2939–48.
27. Kim Y, Je Y. Vitamin D intake, blood 25(OH)D levels, and breast cancer risk or mortality: a meta-analysis. Br J Cancer 2014; 110 (11): 2772–84.
28. Ding EL, Mehta S, Fawzi WW, Giovannucci EL. Interaction of estrogen therapy with calcium and vitamin D supplementation on colorectal cancer risk: reanalysis of Women's Health Initiative randomized trial. Int J Cancer 2008; 122 (8): 1690–4.
29. Chung M, Lee J, Terasawa T et al. Vitamin D with or without calcium supplementation for prevention of cancer and fractures: an updated meta-analysis for the U.S. Preventive Services Task Force. Ann Intern Med 2011; 155 (12): 827–38.
30. Lee JE, Li H, Chan AT et al. Circulating levels of vitamin D and colon and rectal cancer: the Physicians' Health Study and a meta-analysis of prospective studies. Cancer Prev Res (Phila) 2011; 4 (5): 735–43.
31. Touvier M, Chan DS, Lau R, Aune D. Meta-analyses of vitamin D intake, 25-hydroxyvitamin D status, vitamin D receptor polymorphisms, and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev 2011; 20 (5): 1003–16.
32. Lagunova Z, Porojnicu AC. Obesity and increased risk of cancer: does decrease of serum 25-hydroxyvitamin D level with increasing body mass index explain some of the association? Mol Nutr Food Res 2010; 54 (8): 1127–33.
________________________________________________
1. Gromova O.A., Torshin I.Iu., Limanova O.A. i dr. Sravnitel'noe issledovanie dokazatel'noi bazy effektivnosti i bezopasnosti primeneniia peroral'noi i transdermal'noi form zamestitel'noi gormonal'noi terapii estrogenami u zhenshchin v razlichnye vozrastnye periody. Probl. reproduktsii. 2013; 6: 86–96. [in Russian]
2. Lapochkina N.P. Gormonal'nyi status zhenshchin s zabolevaniiami molochnykh zhelez. Vestn. RNTs rentgenoradiologii Minzdrava Rossii (elektronnaia versiia). 2006; 6. [in Russian]
3. Wang K, Li F, Chen L et al. Change in risk of breast cancer after receiving hormone replacement therapy by considering effect-modifiers: a systematic review and dose-response meta-analysis of prospective studies. Oncotarget 2017; 8 (46): 81109–24. DOI: 10.18632/oncotarget.20154
4. Heiss G, Wallace R, Anderson GL et al. Health risks and benefits 3 years after stopping randomized treatment with estrogen and progestin. JAMA 2008; 299 (9): 1036–45.
5. Ettinger B, Wang SM, Leslie RS et al. Evolution of postmenopausal hormone therapy between 2002 and 2009. Menopause 2012; 19 (6): 610–5.
6. Gromova O.A., Torshin I.Iu., Filimonova M.V. Rol' vitaminov v profilaktike raka i effektivnosti protivoopukholevoi terapii: sistematicheskii analiz dokazatel'nykh issledovanii. Terapiia. 2018; 2: 65–74. [in Russian]
7. Gromova O.A., Torshin I.Iu., Uchaikin V.F., Limanova O.A. Rol' vitamina D v podderzhanii protivotuberkuleznogo, antivirusnogo i obshchego protivoinfektsionnogo immuniteta. Infektsionnye bolezni. 2014; 4: 65–74. [in Russian]
8. Gromova O.A., Torshin I.Iu. Vitamin D. Smena paradigmy. Pod red. E.I.Guseva, I.N.Zakharovoi. M.: GEOTAR-Media, 2017. [in Russian]
9. Dou R, Ng K, Giovannucci EL et al. Vitamin D and colorectal cancer: molecular, epidemiological and clinical evidence. Br J Nutr 2016; 115 (9): 1643–60.
10. Gromova O.A., Pronin A.V., Grishina T.R. i dr. Protivoopukholevye effekty akvadetrima vodnogo rastvora mitsell s vitaminom D. Farmateka. 2015; 20: 63–8. [in Russian]
11. Radujkovic A, Schnitzler P, Ho AD et al. Low serum vitamin D levels are associated with shorter survival after first-line azacitidine treatment in patients with myelodysplastic syndrome and secondary oligoblastic acute myeloid leukemia. Clin Nutr 2017; 36 (2): 542–51.
12. Chung M, Lee J, Terasawa T et al. Vitamin D with or without calcium supplementation for prevention of cancer and fractures: an updated meta-analysis for the U.S. Preventive Services Task Force. Ann Intern Med 2011; 155 (12): 827–38.
13. Ma Y, Zhang P, Wang F et al. Association between vitamin D and risk of colorectal cancer: a systematic review of prospective studies. J Clin Oncol 2011; 29 (28): 3775–82.
14. Chen P, Hu P, Xie D et al. Meta-analysis of vitamin D, calcium and the prevention of breast cancer. Breast Cancer Res Treat 2010; 121 (2): 469–77.
15. Gilad LA, Schwartz B. Association of estrogen receptor beta with plasma-membrane caveola components: implication in control of vitamin D receptor. J Mol Endocrinol 2007; 38 (6): 603.
16. Jeong Y, Swami S, Krishnan AV et al. Inhibition of Mouse Breast Tumor-Initiating Cells by Calcitriol and Dietary Vitamin D. Mol Cancer Ther 2015; 14 (8): 1951–61.
17. Lundqvist J, Kirkegaard T, Laenkholm AV et al. Williams syndrome transcription factor (WSTF) acts as an activator of estrogen receptor signaling in breast cancer cells and the effect can be abrogated by 1a,25-dihydroxyvitamin D3. J Steroid Biochem Mol Biol 2017.
18. Pizzorno L. Nothing Boring About Boron. Integr Med (Encinitas) 2015; 14 (4): 35–48.
19. De Sousa Almeida-Filho B, De Luca Vespoli H, Pessoa EC et al. Vitamin D deficiency is associated with poor breast cancer prognostic features in postmenopausal women. J Steroid Biochem Mol Biol 2017; 174: 284–9.
20. Buono G, Giuliano M, De Angelis C et al. Pretreatment Serum Concentration of Vitamin D and Breast Cancer Characteristics: A Prospective Observational Mediterranean Study. Clin Breast Cancer 2017; 17 (7): 559–563.
21. Cadeau C, Fournier A, Mesrine S et al. Interaction between current vitamin D supplementation and menopausal hormone therapy use on breast cancer risk: evidence from the E3N cohort. Am J Clin Nutr 2015; 102 (4): 966–73.
22. Wang D, Velez de-la-Paz OI, Zhai JX, Liu DW. Serum 25-hydroxyvitamin D and breast cancer risk: a meta-analysis of prospective studies. Tumour Biol 2013; 34 (6): 3509–17.
23. Bauer SR, Hankinson SE, Bertone-Johnson ER, Ding EL. Plasma vitamin D levels, menopause, and risk of breast cancer: dose-response meta-analysis of prospective studies. Medicine (Baltimore) 2013; 92 (3): 123–31.
24. Chen P, Li M, Gu X et al. Higher blood 25(OH)D level may reduce the breast cancer risk: evidence from a Chinese population based case-control study and meta-analysis of the observational studies. PLoS One 2013; 8 (1): e49312.
25. Hong Z, Tian C, Zhang X. Dietary calcium intake, vitamin D levels, and breast cancer risk: a dose-response analysis of observational studies. Breast Cancer Res Treat 2012; 136 (1): 309–12.
26. Mohr SB, Gorham ED, Alcaraz JE et al. Serum 25-hydroxyvitamin D and prevention of breast cancer: pooled analysis. Anticancer Res 2011; 31 (9): 2939–48.
27. Kim Y, Je Y. Vitamin D intake, blood 25(OH)D levels, and breast cancer risk or mortality: a meta-analysis. Br J Cancer 2014; 110 (11): 2772–84.
28. Ding EL, Mehta S, Fawzi WW, Giovannucci EL. Interaction of estrogen therapy with calcium and vitamin D supplementation on colorectal cancer risk: reanalysis of Women's Health Initiative randomized trial. Int J Cancer 2008; 122 (8): 1690–4.
29. Chung M, Lee J, Terasawa T et al. Vitamin D with or without calcium supplementation for prevention of cancer and fractures: an updated meta-analysis for the U.S. Preventive Services Task Force. Ann Intern Med 2011; 155 (12): 827–38.
30. Lee JE, Li H, Chan AT et al. Circulating levels of vitamin D and colon and rectal cancer: the Physicians' Health Study and a meta-analysis of prospective studies. Cancer Prev Res (Phila) 2011; 4 (5): 735–43.
31. Touvier M, Chan DS, Lau R, Aune D. Meta-analyses of vitamin D intake, 25-hydroxyvitamin D status, vitamin D receptor polymorphisms, and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev 2011; 20 (5): 1003–16.
32. Lagunova Z, Porojnicu AC. Obesity and increased risk of cancer: does decrease of serum 25-hydroxyvitamin D level with increasing body mass index explain some of the association? Mol Nutr Food Res 2010; 54 (8): 1127–33.
Авторы
О.А.Громова*1,2, И.Ю.Торшин1, Д.Е.Фролова2, Н.П.Лапочкина2, А.Н.Громов1
1. ФГБУ «Федеральный исследовательский центр "Информатика и управление"» РАН. 119333, Россия, Москва, ул. Вавилова, д. 40;
2. ФГБОУ ВО «Ивановская государственная медицинская академия». 153462, Россия, Иваново, пр. Шереметевский, д. 8
*unesco.gromova@gmail.com
1. ФГБУ «Федеральный исследовательский центр "Информатика и управление"» РАН. 119333, Россия, Москва, ул. Вавилова, д. 40;
2. ФГБОУ ВО «Ивановская государственная медицинская академия». 153462, Россия, Иваново, пр. Шереметевский, д. 8
*unesco.gromova@gmail.com
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O.A.Gromova*1,2, I.Yu.Torshin1, D.E.Frolova2, N.P.Lapochkina2, A.N.Gromov1
1. Federal Research Centre "Information and Management" of the Russian Academy of Sciences. 119333, Russian Federation, Moscow, ul. Vavilova, d. 40;
2. Ivanovo State Medical Academy of the Ministry of Health of the Russian Federation. 153462, Russian Federation, Ivanovo, pr. Sheremetevskii, d. 8
*unesco.gromova@gmail.com
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