Этиологическая структура и возможности диагностики аномального маточного кровотечения

1. Capmas P, Pourcelot AG, Giral E et al. Office hysteroscopy: A report of 2402 cases. J Gynecol Obstet Biol Reprod 2016; 45: 445–50.
2. Никитина Т.И., Осадчев В.Б., Бабков К.В., Мухамедзянова В.М. Структура аномальных маточных кровотечений у женщин репродуктивного возраста. Применение современной классификации PALM-COEIN. Фарматека. 2016; 3: 47–51. / Nikitina T.I., Osadchev V.B., Babkov K.V., Muhamedzyanova V.M. Struktura anomal'nyh matochnyh krovotechenij u zhenshchin reproduktivnogo vozrasta. Primenenie sovremennoj klassifikacii PALM-COEIN. Farmateka. 2016; 3: 47–51. [in Russian]
3. Erika Tanaka, Mikio Momoeda, Yutaka Osuga et al. Burden of menstrual symptoms in Japanese women: results from a survey-based study. J Med Economics 2013; 16 (11): 1255–66.
4. Marret H, Fauconnier A, Chabbert-Buffet N et al. Clinical practice guidelines on menorrhagia: management of abnormal uterine bleeding before menopause. Eur J Obstet Gynecol Reprod Biol 2010; 152 (2): 133–7.
5. Michelle Matthews, MD. Abnormal Uterine Bleeding in Reproductive-aged Women. Obstet Gynecol Clin North Am 2015; 42 (1): 103–15.
6. Harlow SD, Campbell OM. Epidemiology of menstrual disorders in developing countries: a systematic review. BJOG 2004; 111: 6–16.
7. Gol K, Saracoglu F, Ekici A, Sahin I. Endometrial patterns and endocrinologic characteristics of asymptomatic menopausal women. Gynecol Endocrinol 2001; 15: 63–7.
8. Munro MG, Critchley HO, Broder MS. FIGO classification system (PALM-COEIN) for causes of abnormal uterine bleeding in nongravid women of reproductiveage. FIGO Working Group on Menstrual Disorders. Int J Gynaecol Obstet 2011; 113: 3–13.
9. Singh S, Best C, Dunn S et al. Society of Obstetricians and Gynaecologists of Canada. Abnormal uterine bleeding in pre-menopausal women. J Obstet Gynaecol Can 2013; 35 (5): 473–9.
10. National Collaborating Centre for Women’s and Children’s Health. Heavy Menstrual Bleeding: NICE Clinical Guidelines 2007; 44: 24–7.
11. Clark TJ, Stevenson H. Endometrial Polyps and Abnormal Uterine Bleeding (AUB-P) – What is the relationship; how are they diagnosed and how are they treated? Best Pract Res Clin Obstet Gynaecol 2017; 40: 89–104.
12. Gon S, Kundu T, Mallick D et al. A Study on Histopathological Patterns of Endometrium in Different Types of Abnormal Uterine Bleeding Among Peri And Postmenopausal Women. J Dent Med Sci (IOSR-JDMS) 2016; 15. Issue 9: 106–11.
13. Abid M, Hashmi A, Malik B et al. Clinical pattern and spectrum of endometrial pathologies in patients with abnormal uterine bleeding in Pakistan: need to adopt a more conservative approach to treatment. BMC Women's Health 2014; 14: 132.
14. El-Mazny A, Abou-Salem N et al. Outpatient hysteroscopy: a routine investigation before assisted reproductive techniques? Fertil Steril 2011; 95 (1): 272–6.
15. Krampl E, Bourne T, Hurlen-Solbakken H, Istre O. Transvaginal ultrasonography sonohysterography and operative hysteroscopy for the evaluation of abnormal uterine bleeding. Acta Obstet Gynecol Scand 2001; 80 (7): 616–22.
16. Schwarzler P, Concin H, Bosch H et al. An evaluation of sonohysterography and diagnostic hysteroscopy for the assessment of intrauterine pathology. Ultrasound Obstet Gynaecol 1998; 11: 337–42.
17. Shapley M, Jordan K, Croft PR. An epidemiological survey of symptoms of menstrual loss in the community. Br J Gen Pract 2004; 54: 359–63
18. Fabres C, Alam V, Balmaceda J et al. Comparison of ultrasonography and hysteroscopy in the diagnosis of intrauterine lesions in infertile women. J Am Assoc Gynecol Laparosc 1998; 5: 375–8.
19. Capmasa P, Pourcelota A, Girala E, Fedidaa D. Office hysteroscopy: a report of 2402 cases. J Gynecol Obstet Biol Reprod (Paris) 2016.
20. Kucur SK, Sencan H, Yuksel KB et al. Evaluatıon of endometrial biopsy results in our clinic; analysis of 744 cases. Zeynep Kamil T1p Bulteni 2014; 45: 146–50.
21. Jetley S, Rana S, Jairajpuri ZS. Morphological spectrum of endometrial pathology in middle-aged women with atypical uterine bleeding: A study of 219 cases. J Midlife Health 2013; 4: 216–20.
22. Mesci-Haftaci S, Ankarali H, Yavuzcan A, Caglar M. Endometrial curettage in abnormal uterine bleeding and efficacy of progestins for control in cases of hyperplasia. Department of Obstetrics and Gynecology, Duzce Public Hospital, Duzce, Turkey Asian Pac. J Cancer Prev 2014; 15 (8): 3737–40.
23. Practice Bulletin No. 128: Diagnosis of Abnormal Uterine Bleeding in Reproductive-Aged Women. Obstet Gynecol 2012; 120 (Issue 1): 197–206.
24. Думановская М.Р. Клиническое значение экспрессии молекулярно-генетических маркеров опухолевого роста при гиперплазии эндометрия и оптимизации гормонотерапии. Автореф. дис. ... канд. мед. наук. М., 2015. / Dumanovskaya M.R. Klinicheskoe znachenie ekspressii molekulyarno-geneticheskih markerov opuholevogo rosta pri giperplazii endometriya i optimizacii gormonoterapii. Avtoref. dis. ... kand. med. nauk. M., 2015. [in Russian]
25. Shiva M, Ahmadi F, Arabipoor A et al. Accuracy of two-dimensional transvaginal sonography and office hysteroscopy for detection of uterine abnormalities in patients with repeated implantation failures or recurrent pregnancy loss. Int J Fertil Steril 2018; 11 (4): 287–92.
26. Babacan A, Gun I, Kizilaslan C et al. Comparison of transvaginal ultrasonography and hysteroscopy in the diagnosis of uterine pathologies. Int J Clin Exp Med 2014; 7 (3): 764–9.
27. Cepni I, Ocal P, Erkan S et al. Comparison of transvaginal sonography, saline infusion sonography and hysteroscopy in the evaluation of uterine cavity pathologies. Aust N Z J Obstet Gynaecol 2005; 45 (1): 30–5.
28. Wanderley MD, Álvares MM, Vogt MF, Sazaki LM. Accuracy of transvaginal ultrasonography, hysteroscopy and uterine curettage in evaluating endometrial pathologies. Rev Bras Ginecol Obstet 2016; 38 (10): 506–11.
29. Tehranian A, Bayani L, Heidary S et al. Diagnostic accuracy of sonohysterography compared to endometrial biopsy in premenopausal women with abnormal uterine bleeding. Med J Islam Repub Iran 2015; 29: 201.

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1. Capmas P, Pourcelot AG, Giral E et al. Office hysteroscopy: A report of 2402 cases. J Gynecol Obstet Biol Reprod 2016; 45: 445–50.
2. Nikitina T.I., Osadchev V.B., Babkov K.V., Muhamedzyanova V.M. Struktura anomal'nyh matochnyh krovotechenij u zhenshchin reproduktivnogo vozrasta. Primenenie sovremennoj klassifikacii PALM-COEIN. Farmateka. 2016; 3: 47–51. [in Russian]
3. Erika Tanaka, Mikio Momoeda, Yutaka Osuga et al. Burden of menstrual symptoms in Japanese women: results from a survey-based study. J Med Economics 2013; 16 (11): 1255–66.
4. Marret H, Fauconnier A, Chabbert-Buffet N et al. Clinical practice guidelines on menorrhagia: management of abnormal uterine bleeding before menopause. Eur J Obstet Gynecol Reprod Biol 2010; 152 (2): 133–7.
5. Michelle Matthews, MD. Abnormal Uterine Bleeding in Reproductive-aged Women. Obstet Gynecol Clin North Am 2015; 42 (1): 103–15.
6. Harlow SD, Campbell OM. Epidemiology of menstrual disorders in developing countries: a systematic review. BJOG 2004; 111: 6–16.
7. Gol K, Saracoglu F, Ekici A, Sahin I. Endometrial patterns and endocrinologic characteristics of asymptomatic menopausal women. Gynecol Endocrinol 2001; 15: 63–7.
8. Munro MG, Critchley HO, Broder MS. FIGO classification system (PALM-COEIN) for causes of abnormal uterine bleeding in nongravid women of reproductiveage. FIGO Working Group on Menstrual Disorders. Int J Gynaecol Obstet 2011; 113: 3–13.
9. Singh S, Best C, Dunn S et al. Society of Obstetricians and Gynaecologists of Canada. Abnormal uterine bleeding in pre-menopausal women. J Obstet Gynaecol Can 2013; 35 (5): 473–9.
10. National Collaborating Centre for Women’s and Children’s Health. Heavy Menstrual Bleeding: NICE Clinical Guidelines 2007; 44: 24–7.
11. Clark TJ, Stevenson H. Endometrial Polyps and Abnormal Uterine Bleeding (AUB-P) – What is the relationship; how are they diagnosed and how are they treated? Best Pract Res Clin Obstet Gynaecol 2017; 40: 89–104.
12. Gon S, Kundu T, Mallick D et al. A Study on Histopathological Patterns of Endometrium in Different Types of Abnormal Uterine Bleeding Among Peri And Postmenopausal Women. J Dent Med Sci (IOSR-JDMS) 2016; 15. Issue 9: 106–11.
13. Abid M, Hashmi A, Malik B et al. Clinical pattern and spectrum of endometrial pathologies in patients with abnormal uterine bleeding in Pakistan: need to adopt a more conservative approach to treatment. BMC Women's Health 2014; 14: 132.
14. El-Mazny A, Abou-Salem N et al. Outpatient hysteroscopy: a routine investigation before assisted reproductive techniques? Fertil Steril 2011; 95 (1): 272–6.
15. Krampl E, Bourne T, Hurlen-Solbakken H, Istre O. Transvaginal ultrasonography sonohysterography and operative hysteroscopy for the evaluation of abnormal uterine bleeding. Acta Obstet Gynecol Scand 2001; 80 (7): 616–22.
16. Schwarzler P, Concin H, Bosch H et al. An evaluation of sonohysterography and diagnostic hysteroscopy for the assessment of intrauterine pathology. Ultrasound Obstet Gynaecol 1998; 11: 337–42.
17. Shapley M, Jordan K, Croft PR. An epidemiological survey of symptoms of menstrual loss in the community. Br J Gen Pract 2004; 54: 359–63
18. Fabres C, Alam V, Balmaceda J et al. Comparison of ultrasonography and hysteroscopy in the diagnosis of intrauterine lesions in infertile women. J Am Assoc Gynecol Laparosc 1998; 5: 375–8.
19. Capmasa P, Pourcelota A, Girala E, Fedidaa D. Office hysteroscopy: a report of 2402 cases. J Gynecol Obstet Biol Reprod (Paris) 2016.
20. Kucur SK, Sencan H, Yuksel KB et al. Evaluatıon of endometrial biopsy results in our clinic; analysis of 744 cases. Zeynep Kamil T1p Bulteni 2014; 45: 146–50.
21. Jetley S, Rana S, Jairajpuri ZS. Morphological spectrum of endometrial pathology in middle-aged women with atypical uterine bleeding: A study of 219 cases. J Midlife Health 2013; 4: 216–20.
22. Mesci-Haftaci S, Ankarali H, Yavuzcan A, Caglar M. Endometrial curettage in abnormal uterine bleeding and efficacy of progestins for control in cases of hyperplasia. Department of Obstetrics and Gynecology, Duzce Public Hospital, Duzce, Turkey Asian Pac. J Cancer Prev 2014; 15 (8): 3737–40.
23. Practice Bulletin No. 128: Diagnosis of Abnormal Uterine Bleeding in Reproductive-Aged Women. Obstet Gynecol 2012; 120 (Issue 1): 197–206.
24. Dumanovskaya M.R. Klinicheskoe znachenie ekspressii molekulyarno-geneticheskih markerov opuholevogo rosta pri giperplazii endometriya i optimizacii gormonoterapii. Avtoref. dis. ... kand. med. nauk. M., 2015. [in Russian]
25. Shiva M, Ahmadi F, Arabipoor A et al. Accuracy of two-dimensional transvaginal sonography and office hysteroscopy for detection of uterine abnormalities in patients with repeated implantation failures or recurrent pregnancy loss. Int J Fertil Steril 2018; 11 (4): 287–92.
26. Babacan A, Gun I, Kizilaslan C et al. Comparison of transvaginal ultrasonography and hysteroscopy in the diagnosis of uterine pathologies. Int J Clin Exp Med 2014; 7 (3): 764–9.
27. Cepni I, Ocal P, Erkan S et al. Comparison of transvaginal sonography, saline infusion sonography and hysteroscopy in the evaluation of uterine cavity pathologies. Aust N Z J Obstet Gynaecol 2005; 45 (1): 30–5.
28. Wanderley MD, Álvares MM, Vogt MF, Sazaki LM. Accuracy of transvaginal ultrasonography, hysteroscopy and uterine curettage in evaluating endometrial pathologies. Rev Bras Ginecol Obstet 2016; 38 (10): 506–11.
29. Tehranian A, Bayani L, Heidary S et al. Diagnostic accuracy of sonohysterography compared to endometrial biopsy in premenopausal women with abnormal uterine bleeding. Med J Islam Repub Iran 2015; 29: 201.

Г.Е.Чернуха*, И.А.Иванов, З.Н.Эфендиева, М.Р.Думановская, А.В.Асатурова

ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова» Минздрава России. 117997, Россия, Москва, ул. Академика Опарина, д. 4
*g_chernukha@oparina4.ru

________________________________________________

G.E.Chernukha*, I.A.Ivanov, Z.N.Efendieva, M.R.Dumanovskaya, A.V.Asaturova

V.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Akademika Oparina, d. 4
*g_chernukha@oparina4.ru