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Репродуктивные нарушения и акушерские осложнения при гинекологических заболеваниях
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Unanian A.L., Sidorova I.S., Nikonets A.D. et al. Reproductive disorders and obstetric complications in gynecological diseases. Gynecology. 2018; 20 (2): 77–81. DOI: 10.26442/2079-5696_2018.2.77-81
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Ключевые слова: акушерские осложнения, прегравидарная подготовка, гинекологические заболевания, комбинированные оральные контрацептивы, антиоксидантная защита, венозная тромбоэмболия, дипиридамол, Курантил.
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This publication examines the existing risks of obstetric complications and other reproductive disorders in women with gynecological diseases. The paper also discusses the issues of the pre-school training of women with gynecological diseases, with special emphasis on the use of dipyridamole, due to its pleiotropic action.
Key words: obstetrical complications, pregravid preparation, gynecological diseases, combined oral contraceptives, antioxidant protection, venous thromboembolism, dipyridamole, Curantyl.
2. Johnson NP, Hummelshoj L. World Endometriosis Society Montpellier Consortium. Consensus on current management of endometriosis. Hum Reprod 2013; 28 (6): 1552–68.
3. Tanbo T, Fedorcsak P. Endometriosis-associated infertility: aspects of pathophysiological mechanisms and treatment options. Acta Obstet Gynecol Scand 2016. DOI: 10.1111/aogs.13082
4. Dunselman GA, Vermeulen N, Becker C et al. ESHRE guideline: management of women with endometriosis. Hum Reprod 2014; 29 (3): 400–12.
5. Jacobson TZ, Duffy JM, Barlow D et al. Laparoscopic surgery for subfertility associated with endometriosis. Cochrane Database Syst Rev 2010: CD001398.
6. Duffy JM, Arambage K, Correa FJ et al. Laparoscopic surgery for endometriosis. Cochrane Database Syst Rev 2014: CD011031.
7. Singh SS, Suen MW. Surgery for endometriosis: beyond medical therapies. Fertil Steril 2017; 107 (3): 549–4.
8. Goodman LR, Goldberg JM, Flyckt RL et al. Effect of surgery on ovarian reserve in women with endometriomas, endometriosis and controls. Am J Obstet Gynecol 2016; 215 (589): e1–6.
9. Hamdan M, Dunselman G, Li TC, Cheong Y. The impact of endometrioma on IVF/ICSI outcomes: a systematic review and meta-analysis. Hum Reprod Update 2015; 21: 809–25.
10. Vercellini P, Somigliana E, Vigano P et al. The effect of second-line surgery on reproductive performance of women with recurrent endometriosis: a systematic review. Acta Obstet Gynecol Scand 2009; 88: 1074–82.
11. Dunselman GA, Vermeulen N, Becker C et al. ESHRE guideline: management of women with endometriosis. Hum Reprod 2014; 29 (3): 400–12.
12. Hughes E, Brown J, Collins JJ et al. Ovulation suppression for endometriosis. Cochrane Database Syst Rev 2007: CD000155.
13. Sallam HN, Garcia-Velasco JA, Dias S, Arici A. Long-term pituitary down-regulation before in vitro fertilization (IVF) for women with endometriosis. Cochrane Database Syst Rev 2006; 1: CD004635.
14. Takemura Y, Osuga Y, Fujimoto A et al. Increased risk of placenta previa is associated with endometriosis and tubal factor infertility in assisted reproductive technology pregnancy. Gynecol Endocrinol 2013; 29: 113–5.
15. Vercellini P, Parazzini F, Pietropaolo G et al. Pregnancy outcome in women with peritoneal, ovarian and rectovaginal endometriosis: a retrospective cohort study. BJOG 2012; 119: 1538–43.
16. Conti N, Cevenini G, Vannuccini S et al. Women with endometriosis at first pregnancy have an increased risk of adverse obstetric outcome. J Matern Fetal Neonatal Med 2014; 9: 1–4.
17. Fernando S, Breheny S, Jaques AM et al. Preterm birth, ovarian endometrioma, and assisted reproduction technologies. Fertil Steril 2009; 91: 325–30.
18. Leone Roberti Maggiore U, Ferrero S, Mangili G et al. A systematic review on endometriosis during pregnancy: diagnosis, misdiagnosis, complications and outcomes. Hum Reprod Update 2016; 22 (1): 70–103.
19. Aris A. A 12-year cohort study on adverse pregnancy outcomes in Eastern Townships of Canada: impact of endometriosis. Gynecol Endocrinol 2014; 30: 34–7.
20. Hashimoto A, Iriyama T, Sayama S et al. Adenomyosis and adverse perinatal outcomes: increased risk of second trimester miscarriage, preeclampsia, and placental malposition. J Matern Fetal Neonatal Med 2017 Feb 9; p. 1–6.
21. Maheshwari A, Gurunath S, Fatima F, Bhattacharya S. Adenomyosis and subfertility: a systematic review of prevalence, diagnosis, treatment and fertility outcomes. Hum Reprod Update 2012; 18 (4): 374–92.
22. Vigano P, Corti L, Berlanda N. Beyond infertility: obstetrical and postpartum complications associated with endometriosis and adenomyosis. Fertil Steril 2015; 104 (4): 802–12.
23. Takebayashi A, Kimura F, Kishi Y. The association between endometriosis and chronic endometritis. PLoS One 2014; 9 (2): e88354.
24. McQueen DB, Bernardi LA, Stephenson MD. Chronic endometritis in women with recurrent early pregnancy loss and/or fetal demise. Fertil Steril 2014; 101 (4): 1026–30.
25. Cicinelli E, Matteo M, Tinelli R. Prevalence of chronic endometritis in repeated unexplained implantation failure and the IVF success rate after antibiotic therapy. Hum Reprod 2015; 30 (2): 323–30.
26. Yang R, Du X, Wang Y et al. The hysteroscopy and histological diagnosis and treatment value of chronic endometritis in recurrent implantation failure patients. Arch Gynecol Obstet 2014; 289: 1363–9.
27. Радзинский В.Е., Киселев В.И., Муйжнек Е.Л. и др. Хронический эндометрит и фертильность: новые ответы. Терапевтические возможности преодоления хронического воспаления в эндометрии и улучшения фертильности: информационный бюллетень. М.: StatusPraesens, 2016. / Radzinskii V.E., Kiselev V.I., Muizhnek E.L. i dr. Khronicheskii endometrit i fertil'nost': novye otvety. Terapevticheskie vozmozhnosti preodoleniia khronicheskogo vospaleniia v endometrii i uluchsheniia fertil'nosti: informatsionnyi biulleten'. M.: StatusPraesens, 2016. [Russian]
28. Balen AH, Morley LC, Misso M et al. The management of anovulatory infertility in women with polycystic ovary syndrome: an analysis of the evidence to support the development of global WHO guidance. Hum Reprod Update 2016; 22 (6): 687–708.
29. Goodman NF et al. American association of clinical endocrinologists, American college of endocrinology, and androgen excess and PCOS society disease state clinical review: guide to the best practices in the evaluation and treatment of polycystic ovary syndrome – PART 2. Endocr Pract 2015; 21 (12): 1415–26.
30. Yu HF, Chen HS, Rao DP, Gong J. Association between polycystic ovary syndrome and the risk of pregnancy complications: A PRISMA-compliant systematic review and meta-analysis. Medicine (Baltimore) 2016; 95 (51): e4863.
31. Klevedal C, Turkmen S. Fetal-maternal outcomes and complications in pregnant women with polycystic ovary syndrome. Minerva Ginecol 2017; 69 (2): 141–9.
32. Li YY, Ye SQ, Zhong ZH et al. Associations between maternal BMI as well as glucose tolerance and adverse pregnancy outcomes in women with polycystic ovary syndrome. Gynecol Endocrinol 2017; 33 (4): 328–31.
33. Klenov VE, Jungheim ES. Obesity and reproductive function: a review of the evidence. Curr Opin Obstet Gynecol 2014; 26: 455–60.
34. Moran L. Weight management to improve outcomes in infertility. Transforming reproductive medicine worldwide. Birmingham: American Society for Reproductive Medicine, 2013; p. 66–73.
35. Kort JD, Winget C, Kim SH, Lathi RB. A retrospective cohort study to evaluate the impact of meaningful weight loss on fertility outcomes in an overweight population with infertility. Fertil Steril 2014; 101 (5): 1400–3.
36. Garvey WT, Mechanick JI, Brett EM et al. Reviewers of the AACE/ACE Obesity Clinical Practice Guidelines. American Assosiation of Clinical Endocrinologists and American College of Endocrinology Comprehensive Clinical Practice Guidelines for medical care of patients with obesity. Edocr Pract 2016; Suppl 3: 1–203.
37. Cornthwaite K, Jefferys A, Lenguerrand E et al. Pregnancy after weight loss surgery: a commentary. BJOG 2016; 123: 165–70.
38. Brown J, Farquhar C. Clomiphene and other antioestrogens for ovulation induction in polycystic ovarian syndrome. Cochrane Database Syst Rev 2016; 12: CD002249.
39. Franik S, Kremer JA, Nelen WL. Aromatase inhibitors for subfertile women with polycystic ovary syndrome. Cochrane Database Syst Rev 2014; 2: CD010287.
40. Legro RS, Arslanian SA, Ehrmann DA. Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2013; 98 (12): 4565–92.
41. Conti N, Tosti C, Pinzauti S et al. Uterine fibroids affect pregnancy outcome in women over 30 years old: role of other risk factors. J Matern Fetal Neonatal Med 2013; 26: 584–7.
42. Shavell VI, Thakur M, Sawant A et al. Adverse obstetric outcomes associated with sonographically identified large uterine fibroids. Fertil Steril 2012; 97: 107–10.
43. Lam SJ, Best S, Kumar S. The impact of fibroid characteristics on pregnancy outcome. Am J Obstet Gynecol 2014; 211: 395.
44. Deveer M, Deveer R, Engin-Ustun Y et al. Comparison of pregnancy outcomes in different localizations of uterine fibroids. Clin Exp Obstet Gynecol 2012; 39: 516–8.
45. Cheung A, Sierra S, Carranza-Mamane B et al. The management of uterine fibroids in women with otherwise unexplained infertility. J Obstet Gynaecol Can 2015; 37 (3): 277–85.
46. Palmer JE, Perunovic B, Tidy JA. Endometrial hyperplasia. Obstet Gynaecologist 2008; 10: 211–6.
47. Owens GL, Kitchener HC. Premalignant disease in the genital tract in pregnancy. Best Pract Res Clin Obstet Gynaecol 2016; 33: 33–43.
48. Gunderson CC, Fader AN, Carson KA, Bristow RE. Oncologic and reproductive outcomes with progestin therapy in women with endometrial hyperplasia and grade 1 adenocarcinoma: a systematic review. Gynecol Oncol 2012; 125: 477–82.
49. Poon LC, Savvas M, Zamblera D et al. Large loop excision of transformation zone and cervical length in the prediction of spontaneous preterm delivery. BJOG: an international journal of obstetrics and gynaecology 2012; 119 (6): 692–8.
50. Kyrgiou M, Mitra A, Arbyn M et al. Fertility and early pregnancy outcomes after treatment for cervical intraepithelial neoplasia: systematic review and meta-analysis. BMJ 2014; 349: g6192.
51. Kyrgiou M, Athanasiou A, Paraskevaidi M et al. Adverse obstetric outcomes after local treatment for cervical preinvasive and early invasive disease according to cone depth: systematic review and meta-analysis. BMJ 2016; 354: i3633.
52. Kindinger LM, Kyrgiou M, MacIntyre DA. Preterm Birth Prevention Post-Conization: A Model of Cervical Length Screening with Targeted Cerclage. PLoS One 2016; 11 (11): e0163793.
53. Balakumar P, Nyo YH, Renushia R, Raaginey D. Classical and pleiotropic actions of dipyridamole: Not enough light to illuminate the dark tunnel? Pharmacol Res 2014; 87: 144–50.
54. Van Hylckama Vlieg A, Helmerhorst FM, Vandenbroucke JP et al. The venous thrombotic risk of oral contraceptives, effects of oestrogen dose and progestogen type: results of the MEGA case-control study. BMJ 2009; 339: b2921.
55. Okoroh EM, Hooper WC, Atrash HK et al. Is polycystic ovary syndrome another risk factor for venous thromboembolism? United States, 2003–2008. Am J Obstet Gynecol 2012; 207 (5), 377: e1–8.
56. Okoroh EM, Boulet SL, George MG et al. Assessing the intersection of cardiovascular disease, venous thromboembolism, and polycystic ovary syndrome. Thromb Res 2015; 136 (6): 1165–8.
57. Sugiura K, Kobayashi T, Ojima T. Risks of thromboembolism associated with hormonal contraceptives related to body mass index and aging in Japanese women. Thromb Res 2016; 137: 11–6.
58. Yamanaka A, Kimura F, Yoshida T et al. Dysfunctional coagulation and fibrinolysis systems due to adenomyosis is a possible cause of thrombosis and menorrhagia. Eur J Obstet Gynecol Reprod Biol 2016; 204: 99–103. DOI: 10.1016/j.ejogrb.2016.07.499
59. Eisert WG. Dipyridamole in antithrombotic treatment. Adv Cardiol 2012; 47: 78–86.
60. Santanam N, Kavtaradze N, Murphy A et al. Antioxidant supplementation reduces endometriosis-related pelvic pain in humans. Transl Res 2013; 161 (3): 189–95. DOI: 10.1016/j.trsl.2012.05.001
61. Ciacciarelli M, Zerbinati C, Violi F, Iuliano L. Dipyridamole: a drug with unrecognized antioxidant activity. Curr Top Med Chem 2015; 15 (9): 822–9.
62. Сидорова И.С., Леваков С.А., Унанян А.Л. Комплексная консервативная терапия миомы матки в сочетании с аденомиозом: применение препарата «Курантил®». Consilium Medicum. 2007; 9 (6): 21–4. / Sidorova I.S., Levakov S.A., Unanian A.L. Kompleksnaia konservativnaia terapiia miomy matki v sochetanii s adenomiozom: primenenie preparata «Kurantil». Consilium Medicum. 2007; 9 (6): 21–4. [in Russian]
63. Сидорова И.С., Унанян А.Л., Власов Р.С. Роль антиагрегантной терапии в лечении хронического эндометрита. Гинекология. 2009; 11 (4): 33–6. / Sidorova I.S., Unanian A.L., Vlasov R.S. Rol' antiagregantnoi terapii v lechenii khronicheskogo endometrita. Gynecology. 2009; 11 (4): 33–6. [in Russian]
64. Унанян А.Л., Аракелов С.Э., Полонская Л.С. и др. Плацентарная недостаточность: особенности этиопатогенеза, терапии и профилактики. Consilium Medicum. 2015; 17 (6): 37–40. / Unanian A.L., Arakelov S.E., Polonskaia L.S. i dr. Platsentarnaia nedostatochnost': osobennosti etiopatogeneza, terapii i profilaktiki. Consilium Medicum. 2015; 17 (6): 37–40. [in Russian]
65. Kelly R, Holzman C, Senagore P et al. Placental vascular pathology findings and pathways of preterm delivery. Am J Epidemiol 2009; 170: 148–58.
66. Van Vliet EO, Askie LA, Mol BW, Oudijk MA. Antiplatelet Agents and the Prevention of Spontaneous Preterm Birth: A Systematic Review and Meta-analysis. Obstet Gynecol 2017; 129 (2): 327–36.
67. Duley L, Henderson-Smart DJ, Meher S, King JF. Antiplatelet agents for preventing pre-eclampsia and its complications. Cochrane Database Syst Rev 2007; 2: CD004659.
________________________________________________
1. Vannuccini S, Clifton VL, Fraser IS et al. Infertility and reproductive disorders: impact of hormonal and inflammatory mechanisms on pregnancy outcome. Hum Reprod Update 2016; 22 (1): 104–15.
2. Johnson NP, Hummelshoj L. World Endometriosis Society Montpellier Consortium. Consensus on current management of endometriosis. Hum Reprod 2013; 28 (6): 1552–68.
3. Tanbo T, Fedorcsak P. Endometriosis-associated infertility: aspects of pathophysiological mechanisms and treatment options. Acta Obstet Gynecol Scand 2016. DOI: 10.1111/aogs.13082
4. Dunselman GA, Vermeulen N, Becker C et al. ESHRE guideline: management of women with endometriosis. Hum Reprod 2014; 29 (3): 400–12.
5. Jacobson TZ, Duffy JM, Barlow D et al. Laparoscopic surgery for subfertility associated with endometriosis. Cochrane Database Syst Rev 2010: CD001398.
6. Duffy JM, Arambage K, Correa FJ et al. Laparoscopic surgery for endometriosis. Cochrane Database Syst Rev 2014: CD011031.
7. Singh SS, Suen MW. Surgery for endometriosis: beyond medical therapies. Fertil Steril 2017; 107 (3): 549–4.
8. Goodman LR, Goldberg JM, Flyckt RL et al. Effect of surgery on ovarian reserve in women with endometriomas, endometriosis and controls. Am J Obstet Gynecol 2016; 215 (589): e1–6.
9. Hamdan M, Dunselman G, Li TC, Cheong Y. The impact of endometrioma on IVF/ICSI outcomes: a systematic review and meta-analysis. Hum Reprod Update 2015; 21: 809–25.
10. Vercellini P, Somigliana E, Vigano P et al. The effect of second-line surgery on reproductive performance of women with recurrent endometriosis: a systematic review. Acta Obstet Gynecol Scand 2009; 88: 1074–82.
11. Dunselman GA, Vermeulen N, Becker C et al. ESHRE guideline: management of women with endometriosis. Hum Reprod 2014; 29 (3): 400–12.
12. Hughes E, Brown J, Collins JJ et al. Ovulation suppression for endometriosis. Cochrane Database Syst Rev 2007: CD000155.
13. Sallam HN, Garcia-Velasco JA, Dias S, Arici A. Long-term pituitary down-regulation before in vitro fertilization (IVF) for women with endometriosis. Cochrane Database Syst Rev 2006; 1: CD004635.
14. Takemura Y, Osuga Y, Fujimoto A et al. Increased risk of placenta previa is associated with endometriosis and tubal factor infertility in assisted reproductive technology pregnancy. Gynecol Endocrinol 2013; 29: 113–5.
15. Vercellini P, Parazzini F, Pietropaolo G et al. Pregnancy outcome in women with peritoneal, ovarian and rectovaginal endometriosis: a retrospective cohort study. BJOG 2012; 119: 1538–43.
16. Conti N, Cevenini G, Vannuccini S et al. Women with endometriosis at first pregnancy have an increased risk of adverse obstetric outcome. J Matern Fetal Neonatal Med 2014; 9: 1–4.
17. Fernando S, Breheny S, Jaques AM et al. Preterm birth, ovarian endometrioma, and assisted reproduction technologies. Fertil Steril 2009; 91: 325–30.
18. Leone Roberti Maggiore U, Ferrero S, Mangili G et al. A systematic review on endometriosis during pregnancy: diagnosis, misdiagnosis, complications and outcomes. Hum Reprod Update 2016; 22 (1): 70–103.
19. Aris A. A 12-year cohort study on adverse pregnancy outcomes in Eastern Townships of Canada: impact of endometriosis. Gynecol Endocrinol 2014; 30: 34–7.
20. Hashimoto A, Iriyama T, Sayama S et al. Adenomyosis and adverse perinatal outcomes: increased risk of second trimester miscarriage, preeclampsia, and placental malposition. J Matern Fetal Neonatal Med 2017 Feb 9; p. 1–6.
21. Maheshwari A, Gurunath S, Fatima F, Bhattacharya S. Adenomyosis and subfertility: a systematic review of prevalence, diagnosis, treatment and fertility outcomes. Hum Reprod Update 2012; 18 (4): 374–92.
22. Vigano P, Corti L, Berlanda N. Beyond infertility: obstetrical and postpartum complications associated with endometriosis and adenomyosis. Fertil Steril 2015; 104 (4): 802–12.
23. Takebayashi A, Kimura F, Kishi Y. The association between endometriosis and chronic endometritis. PLoS One 2014; 9 (2): e88354.
24. McQueen DB, Bernardi LA, Stephenson MD. Chronic endometritis in women with recurrent early pregnancy loss and/or fetal demise. Fertil Steril 2014; 101 (4): 1026–30.
25. Cicinelli E, Matteo M, Tinelli R. Prevalence of chronic endometritis in repeated unexplained implantation failure and the IVF success rate after antibiotic therapy. Hum Reprod 2015; 30 (2): 323–30.
26. Yang R, Du X, Wang Y et al. The hysteroscopy and histological diagnosis and treatment value of chronic endometritis in recurrent implantation failure patients. Arch Gynecol Obstet 2014; 289: 1363–9.
27. Radzinskii V.E., Kiselev V.I., Muizhnek E.L. i dr. Khronicheskii endometrit i fertil'nost': novye otvety. Terapevticheskie vozmozhnosti preodoleniia khronicheskogo vospaleniia v endometrii i uluchsheniia fertil'nosti: informatsionnyi biulleten'. M.: StatusPraesens, 2016. [Russian]
28. Balen AH, Morley LC, Misso M et al. The management of anovulatory infertility in women with polycystic ovary syndrome: an analysis of the evidence to support the development of global WHO guidance. Hum Reprod Update 2016; 22 (6): 687–708.
29. Goodman NF et al. American association of clinical endocrinologists, American college of endocrinology, and androgen excess and PCOS society disease state clinical review: guide to the best practices in the evaluation and treatment of polycystic ovary syndrome – PART 2. Endocr Pract 2015; 21 (12): 1415–26.
30. Yu HF, Chen HS, Rao DP, Gong J. Association between polycystic ovary syndrome and the risk of pregnancy complications: A PRISMA-compliant systematic review and meta-analysis. Medicine (Baltimore) 2016; 95 (51): e4863.
31. Klevedal C, Turkmen S. Fetal-maternal outcomes and complications in pregnant women with polycystic ovary syndrome. Minerva Ginecol 2017; 69 (2): 141–9.
32. Li YY, Ye SQ, Zhong ZH et al. Associations between maternal BMI as well as glucose tolerance and adverse pregnancy outcomes in women with polycystic ovary syndrome. Gynecol Endocrinol 2017; 33 (4): 328–31.
33. Klenov VE, Jungheim ES. Obesity and reproductive function: a review of the evidence. Curr Opin Obstet Gynecol 2014; 26: 455–60.
34. Moran L. Weight management to improve outcomes in infertility. Transforming reproductive medicine worldwide. Birmingham: American Society for Reproductive Medicine, 2013; p. 66–73.
35. Kort JD, Winget C, Kim SH, Lathi RB. A retrospective cohort study to evaluate the impact of meaningful weight loss on fertility outcomes in an overweight population with infertility. Fertil Steril 2014; 101 (5): 1400–3.
36. Garvey WT, Mechanick JI, Brett EM et al. Reviewers of the AACE/ACE Obesity Clinical Practice Guidelines. American Assosiation of Clinical Endocrinologists and American College of Endocrinology Comprehensive Clinical Practice Guidelines for medical care of patients with obesity. Edocr Pract 2016; Suppl 3: 1–203.
37. Cornthwaite K, Jefferys A, Lenguerrand E et al. Pregnancy after weight loss surgery: a commentary. BJOG 2016; 123: 165–70.
38. Brown J, Farquhar C. Clomiphene and other antioestrogens for ovulation induction in polycystic ovarian syndrome. Cochrane Database Syst Rev 2016; 12: CD002249.
39. Franik S, Kremer JA, Nelen WL. Aromatase inhibitors for subfertile women with polycystic ovary syndrome. Cochrane Database Syst Rev 2014; 2: CD010287.
40. Legro RS, Arslanian SA, Ehrmann DA. Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2013; 98 (12): 4565–92.
41. Conti N, Tosti C, Pinzauti S et al. Uterine fibroids affect pregnancy outcome in women over 30 years old: role of other risk factors. J Matern Fetal Neonatal Med 2013; 26: 584–7.
42. Shavell VI, Thakur M, Sawant A et al. Adverse obstetric outcomes associated with sonographically identified large uterine fibroids. Fertil Steril 2012; 97: 107–10.
43. Lam SJ, Best S, Kumar S. The impact of fibroid characteristics on pregnancy outcome. Am J Obstet Gynecol 2014; 211: 395.
44. Deveer M, Deveer R, Engin-Ustun Y et al. Comparison of pregnancy outcomes in different localizations of uterine fibroids. Clin Exp Obstet Gynecol 2012; 39: 516–8.
45. Cheung A, Sierra S, Carranza-Mamane B et al. The management of uterine fibroids in women with otherwise unexplained infertility. J Obstet Gynaecol Can 2015; 37 (3): 277–85.
46. Palmer JE, Perunovic B, Tidy JA. Endometrial hyperplasia. Obstet Gynaecologist 2008; 10: 211–6.
47. Owens GL, Kitchener HC. Premalignant disease in the genital tract in pregnancy. Best Pract Res Clin Obstet Gynaecol 2016; 33: 33–43.
48. Gunderson CC, Fader AN, Carson KA, Bristow RE. Oncologic and reproductive outcomes with progestin therapy in women with endometrial hyperplasia and grade 1 adenocarcinoma: a systematic review. Gynecol Oncol 2012; 125: 477–82.
49. Poon LC, Savvas M, Zamblera D et al. Large loop excision of transformation zone and cervical length in the prediction of spontaneous preterm delivery. BJOG: an international journal of obstetrics and gynaecology 2012; 119 (6): 692–8.
50. Kyrgiou M, Mitra A, Arbyn M et al. Fertility and early pregnancy outcomes after treatment for cervical intraepithelial neoplasia: systematic review and meta-analysis. BMJ 2014; 349: g6192.
51. Kyrgiou M, Athanasiou A, Paraskevaidi M et al. Adverse obstetric outcomes after local treatment for cervical preinvasive and early invasive disease according to cone depth: systematic review and meta-analysis. BMJ 2016; 354: i3633.
52. Kindinger LM, Kyrgiou M, MacIntyre DA. Preterm Birth Prevention Post-Conization: A Model of Cervical Length Screening with Targeted Cerclage. PLoS One 2016; 11 (11): e0163793.
53. Balakumar P, Nyo YH, Renushia R, Raaginey D. Classical and pleiotropic actions of dipyridamole: Not enough light to illuminate the dark tunnel? Pharmacol Res 2014; 87: 144–50.
54. Van Hylckama Vlieg A, Helmerhorst FM, Vandenbroucke JP et al. The venous thrombotic risk of oral contraceptives, effects of oestrogen dose and progestogen type: results of the MEGA case-control study. BMJ 2009; 339: b2921.
55. Okoroh EM, Hooper WC, Atrash HK et al. Is polycystic ovary syndrome another risk factor for venous thromboembolism? United States, 2003–2008. Am J Obstet Gynecol 2012; 207 (5), 377: e1–8.
56. Okoroh EM, Boulet SL, George MG et al. Assessing the intersection of cardiovascular disease, venous thromboembolism, and polycystic ovary syndrome. Thromb Res 2015; 136 (6): 1165–8.
57. Sugiura K, Kobayashi T, Ojima T. Risks of thromboembolism associated with hormonal contraceptives related to body mass index and aging in Japanese women. Thromb Res 2016; 137: 11–6.
58. Yamanaka A, Kimura F, Yoshida T et al. Dysfunctional coagulation and fibrinolysis systems due to adenomyosis is a possible cause of thrombosis and menorrhagia. Eur J Obstet Gynecol Reprod Biol 2016; 204: 99–103. DOI: 10.1016/j.ejogrb.2016.07.499
59. Eisert WG. Dipyridamole in antithrombotic treatment. Adv Cardiol 2012; 47: 78–86.
60. Santanam N, Kavtaradze N, Murphy A et al. Antioxidant supplementation reduces endometriosis-related pelvic pain in humans. Transl Res 2013; 161 (3): 189–95. DOI: 10.1016/j.trsl.2012.05.001
61. Ciacciarelli M, Zerbinati C, Violi F, Iuliano L. Dipyridamole: a drug with unrecognized antioxidant activity. Curr Top Med Chem 2015; 15 (9): 822–9.
62. Sidorova I.S., Levakov S.A., Unanian A.L. Kompleksnaia konservativnaia terapiia miomy matki v sochetanii s adenomiozom: primenenie preparata «Kurantil». Consilium Medicum. 2007; 9 (6): 21–4. [in Russian]
63. Sidorova I.S., Unanian A.L., Vlasov R.S. Rol' antiagregantnoi terapii v lechenii khronicheskogo endometrita. Gynecology. 2009; 11 (4): 33–6. [in Russian]
64. Unanian A.L., Arakelov S.E., Polonskaia L.S. i dr. Platsentarnaia nedostatochnost': osobennosti etiopatogeneza, terapii i profilaktiki. Consilium Medicum. 2015; 17 (6): 37–40. [in Russian]
65. Kelly R, Holzman C, Senagore P et al. Placental vascular pathology findings and pathways of preterm delivery. Am J Epidemiol 2009; 170: 148–58.
66. Van Vliet EO, Askie LA, Mol BW, Oudijk MA. Antiplatelet Agents and the Prevention of Spontaneous Preterm Birth: A Systematic Review and Meta-analysis. Obstet Gynecol 2017; 129 (2): 327–36.
67. Duley L, Henderson-Smart DJ, Meher S, King JF. Antiplatelet agents for preventing pre-eclampsia and its complications. Cochrane Database Syst Rev 2007; 2: CD004659.
1. ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М.Сеченова» Минздрава России. 119991, Россия, Москва, ул. Трубецкая, д. 8, стр. 2;
2. Клиническая больница №2 МЕДСИ. 125284, Россия, Москава, 2-й Боткинский пр., д. 5;
3. ГБУЗ «Городская поликлиника №68» Департамента здравоохранения г. Москвы. 119180, Россия, Москва, ул. Малая Якиманка, д. 22, стр. 1
*9603526@mail.ru
________________________________________________
A.L.Unanian*1, I.S.Sidorova1, A.D.Nikonets1, L.N.Aminova2, V.A.Alimov2, A.V.Shchukina3, Yu.V.Chushkov1, D.V.Baburin1
1. I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation. 119991, Russian Federation, Moscow, ul. Trubetskaia, d. 8, str. 2;
2. Clinical Hospital №2 MEDSI. 125284, Russian Federation, Moscow, 2-i Botkinskii pr., d. 5;
3. Сity Hospital №68 of the Department of Health of Moscow. 119180, Russian Federation, Moscow, ul. Malaya Yakimanka, d. 22, str. 1
*9603526@mail.ru