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Современные методы воздействия, направленные на повышение рецептивности эндометрия у пациенток с безуспешными попытками экстракорпорального оплодотворения (обзор литературы)
Современные методы воздействия, направленные на повышение рецептивности эндометрия у пациенток с безуспешными попытками экстракорпорального оплодотворения (обзор литературы)
Половнева М.И., Корнеева И.Е., Бурменская О.В. Современные методы воздействия, направленные на повышение рецептивности эндометрия у пациенток с безуспешными попытками экстракорпорального оплодотворения (обзор литературы). Гинекология. 2018; 20 (3): 66–70.
DOI: 10.26442/2079-5696_2018.3.66-70
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Аннотация
Цель исследования – провести обзор современной литературы, посвященной методам, направленным на повышение рецептивных свойств эндометрия у женщин с повторными неудачными имплантациями.
Материалы и методы. Для написания данного обзора был осуществлен поиск отечественных и зарубежных публикаций в международной системе поиска PubMed за последние 7–10 лет.
Результаты. В обзор литературы включены работы, посвященные изучению роли скретчинга (локального незначительного повреждения эндометрия), внутриматочного введения гранулоцитарного фактора роста, плазмы, обогащенной тромбоцитами, мононуклеаров периферической крови в качестве методов лечения пациенток с повторными безуспешными попытками экстракорпорального оплодотворения, а также методических подходов определения рецептивного статуса эндометрия.
Заключение. Поиск дополнительных методов лечения и обследования пациенток с бесплодием с целью повышения результативности циклов экстракорпорального оплодотворения продолжается. Возможно, разработка и внедрение в клиническую практику новых систем по определению персональных предикторов рецептивности эндометрия позволят создать положительный эффект в терапии пациенток с повторными неудачными имплантациями.
Ключевые слова: рецептивность эндометрия, повторные неудачные имплантации, экстракорпоральное оплодотворение, скретчинг, плазма, обогащенная тромбоцитами, мононуклеары периферической крови, колониестимулирующий фактор роста, окно имплантации.
Materials and methods. The review includes the data of foreign and Russia papers published on PubMed during the last 7–10 years.
Results. There are studies described the role of endometrial scratching, infusion granulocyte colony stimulating factor, autologous peripheral blood mononuclear cells, autologous platelet-rich plasma, the endometrial receptivity array in treatment for patients with repeated implantation failure.
Conclusion. Several adjuvant therapies and diagnostic tests have been used along with IVF to increase the pregnancy rates for women with repeated implantation failure. Perhaps a new test-system to find personal predictors of endometrial receptivity can tern up a positive effect at patients with RIF.
Key words: endometrial receptivity, IVF, ART, repeated unsuccessful implantations, scratching, infusion granulocyte colony stimulating factor, autologous peripheral blood mononuclear cells, autologous platelet-rich plasma, implantation window.
Материалы и методы. Для написания данного обзора был осуществлен поиск отечественных и зарубежных публикаций в международной системе поиска PubMed за последние 7–10 лет.
Результаты. В обзор литературы включены работы, посвященные изучению роли скретчинга (локального незначительного повреждения эндометрия), внутриматочного введения гранулоцитарного фактора роста, плазмы, обогащенной тромбоцитами, мононуклеаров периферической крови в качестве методов лечения пациенток с повторными безуспешными попытками экстракорпорального оплодотворения, а также методических подходов определения рецептивного статуса эндометрия.
Заключение. Поиск дополнительных методов лечения и обследования пациенток с бесплодием с целью повышения результативности циклов экстракорпорального оплодотворения продолжается. Возможно, разработка и внедрение в клиническую практику новых систем по определению персональных предикторов рецептивности эндометрия позволят создать положительный эффект в терапии пациенток с повторными неудачными имплантациями.
Ключевые слова: рецептивность эндометрия, повторные неудачные имплантации, экстракорпоральное оплодотворение, скретчинг, плазма, обогащенная тромбоцитами, мононуклеары периферической крови, колониестимулирующий фактор роста, окно имплантации.
________________________________________________
Materials and methods. The review includes the data of foreign and Russia papers published on PubMed during the last 7–10 years.
Results. There are studies described the role of endometrial scratching, infusion granulocyte colony stimulating factor, autologous peripheral blood mononuclear cells, autologous platelet-rich plasma, the endometrial receptivity array in treatment for patients with repeated implantation failure.
Conclusion. Several adjuvant therapies and diagnostic tests have been used along with IVF to increase the pregnancy rates for women with repeated implantation failure. Perhaps a new test-system to find personal predictors of endometrial receptivity can tern up a positive effect at patients with RIF.
Key words: endometrial receptivity, IVF, ART, repeated unsuccessful implantations, scratching, infusion granulocyte colony stimulating factor, autologous peripheral blood mononuclear cells, autologous platelet-rich plasma, implantation window.
Полный текст
Список литературы
1. Simon A, Laufer N. Repeated implantation failure: clinical approach. Fertil Steril 2012; 97: 1039–43.
2. IVF-Worldwide.com
3. Moura-Ramos M, Gameiro S, Canavarro MC, Soares I. Assessing infertility stress: re-examining the factor structure of the Fertility Problem Inventory. Hum Reprod 2012; 27: 496–505.
4. Calhaz-Jorge C, de Geyter C, Kupka MS et al. Assisted reproductive technology in Europe, 2012: results generated from European registers by ESHRE. The European IVF-Monitoring Consortium (EIM) for the European Society of Human Reproduction and Embryology (ESHRE). Hum Reprod 2016; 31 (Issue 8): 1638–52.
5. Das M, Holzer HEG. Recurrent implantation failure: gamete and embryo factors. Fertil Steril 2012; 97: 1021–7.
6. Mahajan N. Endometrial receptivity array: Clinical application. J Hum Reprod Sci 2015; 8 (3): 121–9.
7. Barash A, Dekel N, Fieldust S et al. Local injury to the endometrium doubles the incidence of successful pregnancies in patients undergoing in vitro fertilization. Fertil Steril 2003; 79 (6): 1317–22.
8. Gnainsky Y, Granot I, Aldo PB et al. Biopsy-induced inflammatory conditions improve endometrial receptivity: the mechanism of action. Reproduction 2014; 149 (1): 75–85.
9. Gibreel A, El-Adawi N, Elgindy E et al. Endometrial scratching for women with previous IVF failure undergoing IVF treatment. Gynecol Endocrinol 2015; 31 (4): 313–6.
10. Singh N, Toshyan V, Kumar S et al. Does endometrial injury enhances implantation in recurrent in-vitro fertilization failures? A prospective randomized control study from tertiary care center. J Hum Reprod Sci 2015; 8 (4): 218–23.
11. Nastri CO, Lensen SF, Gibreel A et al. Endometrial injury in women undergoing assisted reproductive techniques. Cochrane Database Syst Rev 2015; 3: CD009517.
12. Краснопольская К.В., Назаренко Т.А., Федоров А.А. и др. Клинические исходы программ ЭКО с ооцитами донора при использовании технологии эндометриального скретчинга у пациенток с умеренным экстремальным отставанием развития эндометрия. Мед. алфавит. 2017; 1 (3): 46–50. / Krasnopol'skaya K.V., Nazarenko T.A., Fedorov A.A. i dr. Klinicheskie iskhody programm EKO s oocitami donora pri ispol'zovanii tekhnologii endometrial'nogo skretchinga u pacientok s umerennym ekstremal'nym otstavaniem razvitiya endometriya. Med. alfavit. 2017; 1 (3): 46–50. [in Russian]
13. Levin D, Hasson J, Cohen A et al. The effect of endometrial injury on implantation and clinical pregnancy rates. Gynecol Endocrinol 2017; 33 (10): 779–82. DOI: 10.1080/09513590.2017.1318369
14. Mahran A, Ibrahim M, Bahaa H. The effect of endometrial injury on first cycle IVF/ICSI outcome: A randomized controlled trial. Int J Reprod Biomed (Yazd) 2016; 14 (3): 193–8.
15. Potdar N, Gelbaya T, Nardo LG. Endometrial injury to overcome recurrent embryo implantation failure: a systematic review and meta-analysis. Reprod Biomed Online 2012; 25 (6): 561–71.
16. Yeung TW, Chai J, Li RH et al. The effect of endometrial injury on ongoing pregnancy rate in unselected subfertile women undergoing in vitro fertilization: a randomized controlled trial. Hum Reprod 2014; 29 (11): 2474–81.
17. Liu W, Tal R, Chao H et al. Effect of local endometrial injury in proliferative vs. luteal phase on IVF outcomes in unselected subfertile women undergoing in vitro fertilization. Reprod Biol Endocrinol 2017; 15 (1): 75.
18. Lensen S, Martins W, Nastri C et al. Pipelle for Pregnancy (PIP): study protocols for three randomised controlled trials. Trials 2016; 17 (1): 216.
19. Van Hoogenhuijze NE, Torrance HL, Mol F et al. Endometrial scratching in women with implantation failure after a first IVF/ICSI cycle; does it lead to a higher live birth rate? The SCRaTCH study: a randomized controlled trial (NTR 5342). BMC Womens Health 2017; 17 (1): 47.
20. Lensen S, Sadler L, Farquhar C. Endometrial scratching for subfertility: everyone's doing it. Hum Reprod 2016; 31 (6): 1241–4.
21. Gleicher N, Vidali A, Barad DH. Successful treatment of unresponsive thin endometrium. Fertil Steril 2011; 95: 2123.e13–2123.e17.
22. Davari-Tanha F, Shahrokh Tehraninejad E, Ghazi M, Shahraki Z. The role of G-CSF in recurrent implantation failure: A randomized double blind placebo control trial. Int J Reprod Biomed (Yazd) 2016; 14 (12): 737–42.
23. Li J, Mo S, Chen Y. The effect of G-CSF on infertile women undergoing IVF treatment: A meta-analysis. Syst Biol Reprod Med 2017; 63 (4): 239–47.
24. Kunicki M, Łukaszuk K, Liss J et al. Granulocyte colony stimulating factor treatment of resistant thin endometrium in women with frozen-thawed blastocyst transfer. Syst Biol Reprod Med 2017; 63 (1): 49–57.
25. Fujiwara H. Do circulating blood cells contribute to maternal tissue remodeling and embryo-maternal cross-talk around the implantation period? Mol Hum Reprod 2009; 15: 335–43.
26. Okitsu O, Kiyokawa M, Oda T et al. Intrauterine administration of autologous peripheral blood mononuclear cells increases clinical pregnancy rates in frozen/thawed embryo transfer cycles of patients with repeated implantation failure. J Reprod Immunol 2011; 92 (1–2): 82–7.
27. Yu N, Zhang B, Xu M et al. Intrauterine administration of autologous peripheral blood mononuclear cells (PBMCs) activated by HCG improves the implantation and pregnancy rates in patients with repeated implantation failure: a prospective randomized study. Am J Reprod Immunol 2016; 76 (3): 212–6.
28. Madkour A, Bouamoud N, Louanjli N et al. Intrauterine insemination of cultured peripheral blood mononuclear cells prior to embryo transfer improves clinical outcome for patients with repeated implantation failures. Zygote 2016; 24 (1): 58–69.
29. Li S, Wang J, Cheng Y et al. Intrauterine administration of hCG-activated autologous human peripheral blood mononuclear cells (PBMC) promotes live birth rates in frozen/thawed embryo transfer cycles of patients with repeated implantation failure. J Reprod Immunol 2017; 119: 15–22.
30. Chang Y, Li J, Chen Y et al. Autologous platelet-rich plasma promotes endometrial growth and improves pregnancy outcome during in vitro fertilization. Int J Clin Exp Med 2015; 8 (1): 1286–90. eCollection 2015.
31. Nazari L, Salehpour S, Hoseini S et al. Effects of autologous platelet-rich plasma on implantation and pregnancy in repeated implantation failure: A pilot study. Int J Reprod Biomed (Yazd) 2016; 14 (10): 625–8.
32. Tandulwadkar SR, Naralkar MV, Surana AD et al. Autologous Intrauterine Platelet-Rich Plasma Instillation for Suboptimal Endometrium in Frozen Embryo Transfer Cycles: a Pilot Study. J Hum Reprod Sci 2017; 10 (3): 208–12.
33. Zadehmodarres S, Salehpour S, Saharkhiz N, Nazari L. Treatment of thin endometrium with autologous platelet-rich plasma: a pilot study. JBRA Assist Reprod 2017; 21 (1): 54–6.
34. Molina A, Sánchez J, Sánchez W, Vielma V. Platelet-rich plasma as an adjuvant in the endometrial preparation of patients with refractory endometrium. JBRA Assist Reprod 2018; 22 (1): 42–8.
35. Díaz-Gimeno P, Horcajadas JA, Martínez-Conejero JA et al. A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature. Fertil Steril 2011; 95: 50–60.
36. Ruiz-Alonso M, Galindo N, Pellicer A, Simón C. What a difference two days make: "personalized" embryo transfer (pET) paradigm: a case report and pilot study. Hum Reprod 2014; 29 (6): 1244–7.
37. Hashimoto T, Koizumi M, Doshida M et al. Efficacy of the endometrial receptivity array for repeated implantation failure in Japan: A retrospective, two‐centers study. Reprod Med Biol 2017; 16: 290–6.
38. Tan J, Kan A, Hitkari J et al. The role of the endometrial receptivity array (ERA) in patients who have failed euploid embryo transfers J Assist Reprod Genet 2018.
39. Simon C, Vladimirov IK, Castillon Cortes G et al. Prospective, randomized study of the endometrial receptivity analysis (ERA) test in the infertility work-up to guide personalized embryo transfer versus fresh transfer or deferred embryo transfer. Elsevier 2016; 106. Issue 3 (Suppl.): e46–e47.
40. Sebastian-Leon P, Garrido N, Remohí J et al. Asynchronous and pathological windows of implantation: two causes of recurrent implantation failure. Hum Reprod 2018.
2. IVF-Worldwide.com
3. Moura-Ramos M, Gameiro S, Canavarro MC, Soares I. Assessing infertility stress: re-examining the factor structure of the Fertility Problem Inventory. Hum Reprod 2012; 27: 496–505.
4. Calhaz-Jorge C, de Geyter C, Kupka MS et al. Assisted reproductive technology in Europe, 2012: results generated from European registers by ESHRE. The European IVF-Monitoring Consortium (EIM) for the European Society of Human Reproduction and Embryology (ESHRE). Hum Reprod 2016; 31 (Issue 8): 1638–52.
5. Das M, Holzer HEG. Recurrent implantation failure: gamete and embryo factors. Fertil Steril 2012; 97: 1021–7.
6. Mahajan N. Endometrial receptivity array: Clinical application. J Hum Reprod Sci 2015; 8 (3): 121–9.
7. Barash A, Dekel N, Fieldust S et al. Local injury to the endometrium doubles the incidence of successful pregnancies in patients undergoing in vitro fertilization. Fertil Steril 2003; 79 (6): 1317–22.
8. Gnainsky Y, Granot I, Aldo PB et al. Biopsy-induced inflammatory conditions improve endometrial receptivity: the mechanism of action. Reproduction 2014; 149 (1): 75–85.
9. Gibreel A, El-Adawi N, Elgindy E et al. Endometrial scratching for women with previous IVF failure undergoing IVF treatment. Gynecol Endocrinol 2015; 31 (4): 313–6.
10. Singh N, Toshyan V, Kumar S et al. Does endometrial injury enhances implantation in recurrent in-vitro fertilization failures? A prospective randomized control study from tertiary care center. J Hum Reprod Sci 2015; 8 (4): 218–23.
11. Nastri CO, Lensen SF, Gibreel A et al. Endometrial injury in women undergoing assisted reproductive techniques. Cochrane Database Syst Rev 2015; 3: CD009517.
12. Krasnopol'skaya K.V., Nazarenko T.A., Fedorov A.A. i dr. Klinicheskie iskhody programm EKO s oocitami donora pri ispol'zovanii tekhnologii endometrial'nogo skretchinga u pacientok s umerennym ekstremal'nym otstavaniem razvitiya endometriya. Med. alfavit. 2017; 1 (3): 46–50. [in Russian]
13. Levin D, Hasson J, Cohen A et al. The effect of endometrial injury on implantation and clinical pregnancy rates. Gynecol Endocrinol 2017; 33 (10): 779–82. DOI: 10.1080/09513590.2017.1318369
14. Mahran A, Ibrahim M, Bahaa H. The effect of endometrial injury on first cycle IVF/ICSI outcome: A randomized controlled trial. Int J Reprod Biomed (Yazd) 2016; 14 (3): 193–8.
15. Potdar N, Gelbaya T, Nardo LG. Endometrial injury to overcome recurrent embryo implantation failure: a systematic review and meta-analysis. Reprod Biomed Online 2012; 25 (6): 561–71.
16. Yeung TW, Chai J, Li RH et al. The effect of endometrial injury on ongoing pregnancy rate in unselected subfertile women undergoing in vitro fertilization: a randomized controlled trial. Hum Reprod 2014; 29 (11): 2474–81.
17. Liu W, Tal R, Chao H et al. Effect of local endometrial injury in proliferative vs. luteal phase on IVF outcomes in unselected subfertile women undergoing in vitro fertilization. Reprod Biol Endocrinol 2017; 15 (1): 75.
18. Lensen S, Martins W, Nastri C et al. Pipelle for Pregnancy (PIP): study protocols for three randomised controlled trials. Trials 2016; 17 (1): 216.
19. Van Hoogenhuijze NE, Torrance HL, Mol F et al. Endometrial scratching in women with implantation failure after a first IVF/ICSI cycle; does it lead to a higher live birth rate? The SCRaTCH study: a randomized controlled trial (NTR 5342). BMC Womens Health 2017; 17 (1): 47.
20. Lensen S, Sadler L, Farquhar C. Endometrial scratching for subfertility: everyone's doing it. Hum Reprod 2016; 31 (6): 1241–4.
21. Gleicher N, Vidali A, Barad DH. Successful treatment of unresponsive thin endometrium. Fertil Steril 2011; 95: 2123.e13–2123.e17.
22. Davari-Tanha F, Shahrokh Tehraninejad E, Ghazi M, Shahraki Z. The role of G-CSF in recurrent implantation failure: A randomized double blind placebo control trial. Int J Reprod Biomed (Yazd) 2016; 14 (12): 737–42.
23. Li J, Mo S, Chen Y. The effect of G-CSF on infertile women undergoing IVF treatment: A meta-analysis. Syst Biol Reprod Med 2017; 63 (4): 239–47.
24. Kunicki M, Łukaszuk K, Liss J et al. Granulocyte colony stimulating factor treatment of resistant thin endometrium in women with frozen-thawed blastocyst transfer. Syst Biol Reprod Med 2017; 63 (1): 49–57.
25. Fujiwara H. Do circulating blood cells contribute to maternal tissue remodeling and embryo-maternal cross-talk around the implantation period? Mol Hum Reprod 2009; 15: 335–43.
26. Okitsu O, Kiyokawa M, Oda T et al. Intrauterine administration of autologous peripheral blood mononuclear cells increases clinical pregnancy rates in frozen/thawed embryo transfer cycles of patients with repeated implantation failure. J Reprod Immunol 2011; 92 (1–2): 82–7.
27. Yu N, Zhang B, Xu M et al. Intrauterine administration of autologous peripheral blood mononuclear cells (PBMCs) activated by HCG improves the implantation and pregnancy rates in patients with repeated implantation failure: a prospective randomized study. Am J Reprod Immunol 2016; 76 (3): 212–6.
28. Madkour A, Bouamoud N, Louanjli N et al. Intrauterine insemination of cultured peripheral blood mononuclear cells prior to embryo transfer improves clinical outcome for patients with repeated implantation failures. Zygote 2016; 24 (1): 58–69.
29. Li S, Wang J, Cheng Y et al. Intrauterine administration of hCG-activated autologous human peripheral blood mononuclear cells (PBMC) promotes live birth rates in frozen/thawed embryo transfer cycles of patients with repeated implantation failure. J Reprod Immunol 2017; 119: 15–22.
30. Chang Y, Li J, Chen Y et al. Autologous platelet-rich plasma promotes endometrial growth and improves pregnancy outcome during in vitro fertilization. Int J Clin Exp Med 2015; 8 (1): 1286–90. eCollection 2015.
31. Nazari L, Salehpour S, Hoseini S et al. Effects of autologous platelet-rich plasma on implantation and pregnancy in repeated implantation failure: A pilot study. Int J Reprod Biomed (Yazd) 2016; 14 (10): 625–8.
32. Tandulwadkar SR, Naralkar MV, Surana AD et al. Autologous Intrauterine Platelet-Rich Plasma Instillation for Suboptimal Endometrium in Frozen Embryo Transfer Cycles: a Pilot Study. J Hum Reprod Sci 2017; 10 (3): 208–12.
33. Zadehmodarres S, Salehpour S, Saharkhiz N, Nazari L. Treatment of thin endometrium with autologous platelet-rich plasma: a pilot study. JBRA Assist Reprod 2017; 21 (1): 54–6.
34. Molina A, Sánchez J, Sánchez W, Vielma V. Platelet-rich plasma as an adjuvant in the endometrial preparation of patients with refractory endometrium. JBRA Assist Reprod 2018; 22 (1): 42–8.
35. Díaz-Gimeno P, Horcajadas JA, Martínez-Conejero JA et al. A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature. Fertil Steril 2011; 95: 50–60.
36. Ruiz-Alonso M, Galindo N, Pellicer A, Simón C. What a difference two days make: "personalized" embryo transfer (pET) paradigm: a case report and pilot study. Hum Reprod 2014; 29 (6): 1244–7.
37. Hashimoto T, Koizumi M, Doshida M et al. Efficacy of the endometrial receptivity array for repeated implantation failure in Japan: A retrospective, two‐centers study. Reprod Med Biol 2017; 16: 290–6.
38. Tan J, Kan A, Hitkari J et al. The role of the endometrial receptivity array (ERA) in patients who have failed euploid embryo transfers J Assist Reprod Genet 2018.
39. Simon C, Vladimirov IK, Castillon Cortes G et al. Prospective, randomized study of the endometrial receptivity analysis (ERA) test in the infertility work-up to guide personalized embryo transfer versus fresh transfer or deferred embryo transfer. Elsevier 2016; 106. Issue 3 (Suppl.): e46–e47.
40. Sebastian-Leon P, Garrido N, Remohí J et al. Asynchronous and pathological windows of implantation: two causes of recurrent implantation failure. Hum Reprod 2018.
2. IVF-Worldwide.com
3. Moura-Ramos M, Gameiro S, Canavarro MC, Soares I. Assessing infertility stress: re-examining the factor structure of the Fertility Problem Inventory. Hum Reprod 2012; 27: 496–505.
4. Calhaz-Jorge C, de Geyter C, Kupka MS et al. Assisted reproductive technology in Europe, 2012: results generated from European registers by ESHRE. The European IVF-Monitoring Consortium (EIM) for the European Society of Human Reproduction and Embryology (ESHRE). Hum Reprod 2016; 31 (Issue 8): 1638–52.
5. Das M, Holzer HEG. Recurrent implantation failure: gamete and embryo factors. Fertil Steril 2012; 97: 1021–7.
6. Mahajan N. Endometrial receptivity array: Clinical application. J Hum Reprod Sci 2015; 8 (3): 121–9.
7. Barash A, Dekel N, Fieldust S et al. Local injury to the endometrium doubles the incidence of successful pregnancies in patients undergoing in vitro fertilization. Fertil Steril 2003; 79 (6): 1317–22.
8. Gnainsky Y, Granot I, Aldo PB et al. Biopsy-induced inflammatory conditions improve endometrial receptivity: the mechanism of action. Reproduction 2014; 149 (1): 75–85.
9. Gibreel A, El-Adawi N, Elgindy E et al. Endometrial scratching for women with previous IVF failure undergoing IVF treatment. Gynecol Endocrinol 2015; 31 (4): 313–6.
10. Singh N, Toshyan V, Kumar S et al. Does endometrial injury enhances implantation in recurrent in-vitro fertilization failures? A prospective randomized control study from tertiary care center. J Hum Reprod Sci 2015; 8 (4): 218–23.
11. Nastri CO, Lensen SF, Gibreel A et al. Endometrial injury in women undergoing assisted reproductive techniques. Cochrane Database Syst Rev 2015; 3: CD009517.
12. Краснопольская К.В., Назаренко Т.А., Федоров А.А. и др. Клинические исходы программ ЭКО с ооцитами донора при использовании технологии эндометриального скретчинга у пациенток с умеренным экстремальным отставанием развития эндометрия. Мед. алфавит. 2017; 1 (3): 46–50. / Krasnopol'skaya K.V., Nazarenko T.A., Fedorov A.A. i dr. Klinicheskie iskhody programm EKO s oocitami donora pri ispol'zovanii tekhnologii endometrial'nogo skretchinga u pacientok s umerennym ekstremal'nym otstavaniem razvitiya endometriya. Med. alfavit. 2017; 1 (3): 46–50. [in Russian]
13. Levin D, Hasson J, Cohen A et al. The effect of endometrial injury on implantation and clinical pregnancy rates. Gynecol Endocrinol 2017; 33 (10): 779–82. DOI: 10.1080/09513590.2017.1318369
14. Mahran A, Ibrahim M, Bahaa H. The effect of endometrial injury on first cycle IVF/ICSI outcome: A randomized controlled trial. Int J Reprod Biomed (Yazd) 2016; 14 (3): 193–8.
15. Potdar N, Gelbaya T, Nardo LG. Endometrial injury to overcome recurrent embryo implantation failure: a systematic review and meta-analysis. Reprod Biomed Online 2012; 25 (6): 561–71.
16. Yeung TW, Chai J, Li RH et al. The effect of endometrial injury on ongoing pregnancy rate in unselected subfertile women undergoing in vitro fertilization: a randomized controlled trial. Hum Reprod 2014; 29 (11): 2474–81.
17. Liu W, Tal R, Chao H et al. Effect of local endometrial injury in proliferative vs. luteal phase on IVF outcomes in unselected subfertile women undergoing in vitro fertilization. Reprod Biol Endocrinol 2017; 15 (1): 75.
18. Lensen S, Martins W, Nastri C et al. Pipelle for Pregnancy (PIP): study protocols for three randomised controlled trials. Trials 2016; 17 (1): 216.
19. Van Hoogenhuijze NE, Torrance HL, Mol F et al. Endometrial scratching in women with implantation failure after a first IVF/ICSI cycle; does it lead to a higher live birth rate? The SCRaTCH study: a randomized controlled trial (NTR 5342). BMC Womens Health 2017; 17 (1): 47.
20. Lensen S, Sadler L, Farquhar C. Endometrial scratching for subfertility: everyone's doing it. Hum Reprod 2016; 31 (6): 1241–4.
21. Gleicher N, Vidali A, Barad DH. Successful treatment of unresponsive thin endometrium. Fertil Steril 2011; 95: 2123.e13–2123.e17.
22. Davari-Tanha F, Shahrokh Tehraninejad E, Ghazi M, Shahraki Z. The role of G-CSF in recurrent implantation failure: A randomized double blind placebo control trial. Int J Reprod Biomed (Yazd) 2016; 14 (12): 737–42.
23. Li J, Mo S, Chen Y. The effect of G-CSF on infertile women undergoing IVF treatment: A meta-analysis. Syst Biol Reprod Med 2017; 63 (4): 239–47.
24. Kunicki M, Łukaszuk K, Liss J et al. Granulocyte colony stimulating factor treatment of resistant thin endometrium in women with frozen-thawed blastocyst transfer. Syst Biol Reprod Med 2017; 63 (1): 49–57.
25. Fujiwara H. Do circulating blood cells contribute to maternal tissue remodeling and embryo-maternal cross-talk around the implantation period? Mol Hum Reprod 2009; 15: 335–43.
26. Okitsu O, Kiyokawa M, Oda T et al. Intrauterine administration of autologous peripheral blood mononuclear cells increases clinical pregnancy rates in frozen/thawed embryo transfer cycles of patients with repeated implantation failure. J Reprod Immunol 2011; 92 (1–2): 82–7.
27. Yu N, Zhang B, Xu M et al. Intrauterine administration of autologous peripheral blood mononuclear cells (PBMCs) activated by HCG improves the implantation and pregnancy rates in patients with repeated implantation failure: a prospective randomized study. Am J Reprod Immunol 2016; 76 (3): 212–6.
28. Madkour A, Bouamoud N, Louanjli N et al. Intrauterine insemination of cultured peripheral blood mononuclear cells prior to embryo transfer improves clinical outcome for patients with repeated implantation failures. Zygote 2016; 24 (1): 58–69.
29. Li S, Wang J, Cheng Y et al. Intrauterine administration of hCG-activated autologous human peripheral blood mononuclear cells (PBMC) promotes live birth rates in frozen/thawed embryo transfer cycles of patients with repeated implantation failure. J Reprod Immunol 2017; 119: 15–22.
30. Chang Y, Li J, Chen Y et al. Autologous platelet-rich plasma promotes endometrial growth and improves pregnancy outcome during in vitro fertilization. Int J Clin Exp Med 2015; 8 (1): 1286–90. eCollection 2015.
31. Nazari L, Salehpour S, Hoseini S et al. Effects of autologous platelet-rich plasma on implantation and pregnancy in repeated implantation failure: A pilot study. Int J Reprod Biomed (Yazd) 2016; 14 (10): 625–8.
32. Tandulwadkar SR, Naralkar MV, Surana AD et al. Autologous Intrauterine Platelet-Rich Plasma Instillation for Suboptimal Endometrium in Frozen Embryo Transfer Cycles: a Pilot Study. J Hum Reprod Sci 2017; 10 (3): 208–12.
33. Zadehmodarres S, Salehpour S, Saharkhiz N, Nazari L. Treatment of thin endometrium with autologous platelet-rich plasma: a pilot study. JBRA Assist Reprod 2017; 21 (1): 54–6.
34. Molina A, Sánchez J, Sánchez W, Vielma V. Platelet-rich plasma as an adjuvant in the endometrial preparation of patients with refractory endometrium. JBRA Assist Reprod 2018; 22 (1): 42–8.
35. Díaz-Gimeno P, Horcajadas JA, Martínez-Conejero JA et al. A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature. Fertil Steril 2011; 95: 50–60.
36. Ruiz-Alonso M, Galindo N, Pellicer A, Simón C. What a difference two days make: "personalized" embryo transfer (pET) paradigm: a case report and pilot study. Hum Reprod 2014; 29 (6): 1244–7.
37. Hashimoto T, Koizumi M, Doshida M et al. Efficacy of the endometrial receptivity array for repeated implantation failure in Japan: A retrospective, two‐centers study. Reprod Med Biol 2017; 16: 290–6.
38. Tan J, Kan A, Hitkari J et al. The role of the endometrial receptivity array (ERA) in patients who have failed euploid embryo transfers J Assist Reprod Genet 2018.
39. Simon C, Vladimirov IK, Castillon Cortes G et al. Prospective, randomized study of the endometrial receptivity analysis (ERA) test in the infertility work-up to guide personalized embryo transfer versus fresh transfer or deferred embryo transfer. Elsevier 2016; 106. Issue 3 (Suppl.): e46–e47.
40. Sebastian-Leon P, Garrido N, Remohí J et al. Asynchronous and pathological windows of implantation: two causes of recurrent implantation failure. Hum Reprod 2018.
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22. Davari-Tanha F, Shahrokh Tehraninejad E, Ghazi M, Shahraki Z. The role of G-CSF in recurrent implantation failure: A randomized double blind placebo control trial. Int J Reprod Biomed (Yazd) 2016; 14 (12): 737–42.
23. Li J, Mo S, Chen Y. The effect of G-CSF on infertile women undergoing IVF treatment: A meta-analysis. Syst Biol Reprod Med 2017; 63 (4): 239–47.
24. Kunicki M, Łukaszuk K, Liss J et al. Granulocyte colony stimulating factor treatment of resistant thin endometrium in women with frozen-thawed blastocyst transfer. Syst Biol Reprod Med 2017; 63 (1): 49–57.
25. Fujiwara H. Do circulating blood cells contribute to maternal tissue remodeling and embryo-maternal cross-talk around the implantation period? Mol Hum Reprod 2009; 15: 335–43.
26. Okitsu O, Kiyokawa M, Oda T et al. Intrauterine administration of autologous peripheral blood mononuclear cells increases clinical pregnancy rates in frozen/thawed embryo transfer cycles of patients with repeated implantation failure. J Reprod Immunol 2011; 92 (1–2): 82–7.
27. Yu N, Zhang B, Xu M et al. Intrauterine administration of autologous peripheral blood mononuclear cells (PBMCs) activated by HCG improves the implantation and pregnancy rates in patients with repeated implantation failure: a prospective randomized study. Am J Reprod Immunol 2016; 76 (3): 212–6.
28. Madkour A, Bouamoud N, Louanjli N et al. Intrauterine insemination of cultured peripheral blood mononuclear cells prior to embryo transfer improves clinical outcome for patients with repeated implantation failures. Zygote 2016; 24 (1): 58–69.
29. Li S, Wang J, Cheng Y et al. Intrauterine administration of hCG-activated autologous human peripheral blood mononuclear cells (PBMC) promotes live birth rates in frozen/thawed embryo transfer cycles of patients with repeated implantation failure. J Reprod Immunol 2017; 119: 15–22.
30. Chang Y, Li J, Chen Y et al. Autologous platelet-rich plasma promotes endometrial growth and improves pregnancy outcome during in vitro fertilization. Int J Clin Exp Med 2015; 8 (1): 1286–90. eCollection 2015.
31. Nazari L, Salehpour S, Hoseini S et al. Effects of autologous platelet-rich plasma on implantation and pregnancy in repeated implantation failure: A pilot study. Int J Reprod Biomed (Yazd) 2016; 14 (10): 625–8.
32. Tandulwadkar SR, Naralkar MV, Surana AD et al. Autologous Intrauterine Platelet-Rich Plasma Instillation for Suboptimal Endometrium in Frozen Embryo Transfer Cycles: a Pilot Study. J Hum Reprod Sci 2017; 10 (3): 208–12.
33. Zadehmodarres S, Salehpour S, Saharkhiz N, Nazari L. Treatment of thin endometrium with autologous platelet-rich plasma: a pilot study. JBRA Assist Reprod 2017; 21 (1): 54–6.
34. Molina A, Sánchez J, Sánchez W, Vielma V. Platelet-rich plasma as an adjuvant in the endometrial preparation of patients with refractory endometrium. JBRA Assist Reprod 2018; 22 (1): 42–8.
35. Díaz-Gimeno P, Horcajadas JA, Martínez-Conejero JA et al. A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature. Fertil Steril 2011; 95: 50–60.
36. Ruiz-Alonso M, Galindo N, Pellicer A, Simón C. What a difference two days make: "personalized" embryo transfer (pET) paradigm: a case report and pilot study. Hum Reprod 2014; 29 (6): 1244–7.
37. Hashimoto T, Koizumi M, Doshida M et al. Efficacy of the endometrial receptivity array for repeated implantation failure in Japan: A retrospective, two‐centers study. Reprod Med Biol 2017; 16: 290–6.
38. Tan J, Kan A, Hitkari J et al. The role of the endometrial receptivity array (ERA) in patients who have failed euploid embryo transfers J Assist Reprod Genet 2018.
39. Simon C, Vladimirov IK, Castillon Cortes G et al. Prospective, randomized study of the endometrial receptivity analysis (ERA) test in the infertility work-up to guide personalized embryo transfer versus fresh transfer or deferred embryo transfer. Elsevier 2016; 106. Issue 3 (Suppl.): e46–e47.
40. Sebastian-Leon P, Garrido N, Remohí J et al. Asynchronous and pathological windows of implantation: two causes of recurrent implantation failure. Hum Reprod 2018.
Авторы
М.И.Половнева*, И.Е.Корнеева, О.В.Бурменская
ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова» Минздрава России. 117997, Россия, Москва, ул. Академика Опарина, д. 4
*maria_mir18@mail.ru
V.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Akademika Oparina, d. 4
*maria_mir18@mail.ru
ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова» Минздрава России. 117997, Россия, Москва, ул. Академика Опарина, д. 4
*maria_mir18@mail.ru
________________________________________________
V.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Akademika Oparina, d. 4
*maria_mir18@mail.ru
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