Возможности применения теста самозабора материала при скрининге рака шейки матки (обзор литературы)

1. Горобцова В.В., Ковалев А.А. Рак шейки матки: актуальность проблемы, принципы лечения. Главный врач Юга России. 2016; 1 (48): 63–6. / Gorobcova V.V., Kovalev A.A. Rak shejki matki: aktual'nost' problemy, principy lecheniya. Glavnyj vrach Yuga Rossii. 2016; 1 (48): 63–6. [in Russian]
2. Левшин В.Ф., Завельская А.Я. Факторы риска и профилактика рака шейки матки. Вопр. онкологии. 2017; 63 (3): 506–16. / Levshin V.F., Zavel'skaya A.Ya. Faktory riska i profilaktika raka shejki matki. Vopr. onkologii. 2017; 63 (3): 506–16. [in Russian]
3. Crossley B, Crossley J. A review of the use of human papilloma virus (HPV) in cervical screening. Br J Biomed Sci 2017; 74 (3): 105–9. DOI: 10.1080/09674845.2017.1332555
4. Arbyn M, Anttila A, Jordan J et al. European Guidelines for Quality Assurance in Cervical Cancer Screening: Second edition – Summary document. Ann Oncol 2010; 21: 448–58. DOI: 10.1093/annonc/mdp471
5. Chen K, Ouyang Y, Hillemanns P, Jentschke M. Excellent analytical and clinical performance of a dry self-sampling device for human papillomavirus detection in an urban Chinese referral population. J Obstet Gynaecol Res 2016; 42 (12): 1839–45. DOI: 10.1111/jog.13132
6. De Thurah L, Bonde J, Lam JU, Rebolj M. Concordant testing results between various human papillomavirus assays in primary cervical cancer screening: systematic review. Clin Microbiol Infect 2018; 24 (1): 29–36. DOI: 10.1016/j.cmi.2017.05.020
7. Tjalma WA. The ideal cervical cancer screening recommendation for Belgium, an industrialized country in Europe. Eur J Gynaecol Oncol 2014; 35 (3): 211–8. DOI: 10.1016/j.cmi.2017.05.020
8. Saslow D, Solomon D, Lawson H et al. American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer. Am J Clin Pathol 2012; 137 (4): 516–42. DOI: 10.1309/AJCPTGD94EVRSJCG
9. Zhou H, Mody RR, Luna E et al. Clinical performance of the Food and Drug Administration-Approved high-risk HPV test for the detection of high-grade cervicovaginal lesions. Cancer Cytopathol 2016; 124 (5): 317–23. DOI: 10.1002/cncy.21687
10. Kyrgiou M, Kalliala I, Mitra A et al. Immediate referral to colposcopy versus cytological surveillance for low-grade cervical cytological abnormalities in the absence of HPV test: A systematic review and a meta-analysis of the literature. Int J Cancer 2017; 140 (1): 216–23. DOI: 10.1002/ijc.30419
11. Ronco G, Dillner J, Elfstrom K et al. Efficacy of HPV-based screening for prevention of invasive cervical cancer: follow-up of four European randomised controlled trials. Lancet 2014; 383 (9916): 524–32. DOI: 10.1016/S0140-6736(13)62218-7
12. Cummings MC, Marquart L, Pelecanos A et al. Which are more correctly diagnosed: conventional Papanicolaou smears or Thinprep samples? A comparative study of 9 years of external quality-assurance testing. Cancer Cytopathol 2015; 123 (2): 108–16. DOI: 10.1002/cncy.21498
13. Новик В.И. Скрининг рака шейки матки. Практич. онкология. 2010: 11 (32): 66. / Novik V.I. Skrining raka shejki matki. Praktich. onkologiya. 2010: 11 (32): 66. [in Russian]
14. Cibas ES, Ducatman BS. Cervical and vaginal cytology. Cytology. Diagnostic principles and clinical correlations. Saunders Elsevier 2009.
15. Cuschieri KS, Wentzensen N. Human papillomavirus mRNA and p16 detections as biomarkers for the improved diagnosis of cervical neoplasia. Cancer Epidemiol Biomarkers Prev 2008; 17 (10): 2536. DOI: 10.1158/1055-9965.EPI-08-0306
16. Benevolo M, Allia E, Gustinucci D et al. Interobserver reproducibility of cytologic p16INK4a/Ki-67 dual immunostaining in human papillomavirus positive women. Cancer Cytopathol 2017; 125 (3): 212–20. DOI: 10.1002/cncy.21800
17. Uijterwaal MH, Polman NJ, Witte BI et al. Triaging HPV-positive women with normal cytology by p16/Ki-67 dual-stained cytology testing: baseline and longitudinal data. Int J Cancer 2015; 136 (10): 2361–8. DOI: 10.1002/ijc.29290
18. Wright TC, Behrensb CM, Ranger-Moorec J et al. Triaging HPV-positive women with p16/Ki-67 dual-stained cytology: results from a sub-study nested into the ATHENA trial. Gynecol Oncol 2017; 144 (1) : 51–6. DOI: 10.1016/j.ygyno.2016.10.031
19. Boulet GA, Horvath CA, Depuydt CE, Bogers JJ. Biomarkers in cervical screening: quantitative reverse transcriptase PCR analysis of P16INK4a expression. Eur J Cancer Prev 2010; 19 (1): 35–41. DOI: 10.1097/CEJ.0b013e32833233d4
20. Cheng JY, Feng MJ, Wu CC et al. Development of a sampling collection device with diagnostic procedures. Anal Chem 2016; 88 (15): 7591–6. DOI: 10.1021/acs.analchem.6b01269
21. Tamalet C, Le Retraite L, Leandri F et al. Vaginal self-sampling is an adequate means of screening HR-HPV types in women not participating in regular cervical cancer screening. Clin Microbiol Infect 2013; 19 (1): 44–50. DOI: 10.1111/1469-0691.12063
22. Verdoodt F, Jentschke M, Hillemanns P et al. Reaching women who do not participate in the regular cervical cancer screening programme by offering self-sampling kits: a systematic review and meta-analysis of randomised trials. Eur J Cancer 2015; 51 (16): 2375–85. DOI: 10.1016/j.ejca.2015.07.006
23. Ortiz AP, Alejandro N, Pérez CM et al. Acceptability of Cervical and Anal HPV Self-sampling in a Sample of Hispanic Women in Puerto Rico. PR Health Sci J 2012; 31 (4): 205–12.
24. Darlin L, Borgfeldt C, Forslund O et al. Comparison of use of vaginal HPV self-sampling and offering flexible appointments as strategies to reach long-term non-attending women in organized cervical screening. J Clin Virol 2013; 58 (1): 155–60. DOI: 10.1016/j.jcv.2013.06.029
25. Karjalainen L, Anttila A, Nieminen P et al. Self-sampling in cervical cancer screening: comparison of a brush-based and a lavage-based cervicovaginal self-sampling device. BMC Cancer 2016; 16: 221. DOI: 10.1186/s12885-016-2246-9
26. Johnson DC, Bhatta MP, Smith JS et al. Assessment of high-risk human papillomavirus infections using clinician- and self-collected cervical sampling methods in rural women from far western Nepal. PLoS One 2014; 9 (6): e101255. DOI: 10.1371/journal.pone.0101255
27. Dijkstra MG, Heideman DA, van Kemenade FJ et al. Brush-based selfsampling in combination with GP5+/6+-PCR-based hrHPV testing: high concordance with physician-taken cervical scrapes for HPV genotyping and detection of high-grade CIN. J Clin Virol 2012; 54 (2): 147–51. DOI: 10.1016/j.jcv.2012.02.022
28. Van Baars R, Bosgraaf RP, ter Harmsel BW et al. Dry storage and transport of a cervicovaginal self-sample by use of the Evalyn Brush, providing reliable human papillomavirus detection combined with comfort for women. J Clin Microbiol 2012; 50 (12): 3937–43. DOI: 10.1016/j.jcv.2012.02.022
29. Gustavsson I, Sanner K, Lindell M et al. Type-specific detection of high-risk human papillomavirus (HPV) in self-sampled cervicovaginal cells applied to FTA elute cartridge. J Clin Virol 2011; 51 (4): 255–8. DOI: 10.1016/j.jcv.2011.05.006
30. Qin Y, Zhang H, Marlowe N et al. Evaluation of human papillomavirus detection by Abbott m2000 system on samples collected by FTA Elute Card in a Chinese HIV-1 positive population. J Clin Virol 2016; 85: 80–5. DOI: 10.1016/j.jcv.2016.11.002
31. Arrossi S, Ramos S, Straw C et al. HPV testing: a mixed-method approach to understand why women prefer self-collection in a middle-income country. BMC Public Health 2016; 16: 832–5. DOI: 10.1186/s12889-016-3474-2
32. Marlow LA, Waller J, Wardle J. Barriers to cervical cancer screening among ethnic minority women: a qualitative study. J Fam Plann Reprod Health Care 2015; 41 (4): 248–54.
33. Zehbe I, Jackson R, Wood B et al. Community-randomised controlled trial embedded in the Anishinaabek Cervical Cancer Screening Study: human papillomavirus self-sampling versus Papanicolaou cytology. BMJ Open 2016; 6 (10): e011754. DOI: 10.1136/bmjopen-2016-011754
34. Белокриницкая Т.Е., Фролова Н.И., Туранова О.В. и др. Результативность и приемлемость обследования на вирус папилломы человека при самостоятельном и врачебном заборе вагинального отделяемого. Акуш. и гинекол. 2017; 2: 97–105. / Belokrinickaya T.E., Frolova N.I., Turanova O.V. i dr. Rezul'tativnost' i priemlemost' obsledovaniya na virus papillomy cheloveka pri samostoyatel'nom i vrachebnom zabore vaginal'nogo otdelyaemogo. Akush. i ginekol. 2017; 2: 97–105. [in Russian]
35. Jentschke M, Soergel P, Hillemanns P. Evaluation of a multiplex real time PCR assay for the detection of human papillomavirus infections on self-collected cervicovaginal lavage samples. J Virol Methods 2013; 193 (1): 131–4. DOI: 10.1016/j.jviromet.2013.05.009

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1. Gorobcova V.V., Kovalev A.A. Rak shejki matki: aktual'nost' problemy, principy lecheniya. Glavnyj vrach Yuga Rossii. 2016; 1 (48): 63–6. [in Russian]
2. Levshin V.F., Zavel'skaya A.Ya. Faktory riska i profilaktika raka shejki matki. Vopr. onkologii. 2017; 63 (3): 506–16. [in Russian]
3. Crossley B, Crossley J. A review of the use of human papilloma virus (HPV) in cervical screening. Br J Biomed Sci 2017; 74 (3): 105–9. DOI: 10.1080/09674845.2017.1332555
4. Arbyn M, Anttila A, Jordan J et al. European Guidelines for Quality Assurance in Cervical Cancer Screening: Second edition – Summary document. Ann Oncol 2010; 21: 448–58. DOI: 10.1093/annonc/mdp471
5. Chen K, Ouyang Y, Hillemanns P, Jentschke M. Excellent analytical and clinical performance of a dry self-sampling device for human papillomavirus detection in an urban Chinese referral population. J Obstet Gynaecol Res 2016; 42 (12): 1839–45. DOI: 10.1111/jog.13132
6. De Thurah L, Bonde J, Lam JU, Rebolj M. Concordant testing results between various human papillomavirus assays in primary cervical cancer screening: systematic review. Clin Microbiol Infect 2018; 24 (1): 29–36. DOI: 10.1016/j.cmi.2017.05.020
7. Tjalma WA. The ideal cervical cancer screening recommendation for Belgium, an industrialized country in Europe. Eur J Gynaecol Oncol 2014; 35 (3): 211–8. DOI: 10.1016/j.cmi.2017.05.020
8. Saslow D, Solomon D, Lawson H et al. American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer. Am J Clin Pathol 2012; 137 (4): 516–42. DOI: 10.1309/AJCPTGD94EVRSJCG
9. Zhou H, Mody RR, Luna E et al. Clinical performance of the Food and Drug Administration-Approved high-risk HPV test for the detection of high-grade cervicovaginal lesions. Cancer Cytopathol 2016; 124 (5): 317–23. DOI: 10.1002/cncy.21687
10. Kyrgiou M, Kalliala I, Mitra A et al. Immediate referral to colposcopy versus cytological surveillance for low-grade cervical cytological abnormalities in the absence of HPV test: A systematic review and a meta-analysis of the literature. Int J Cancer 2017; 140 (1): 216–23. DOI: 10.1002/ijc.30419
11. Ronco G, Dillner J, Elfstrom K et al. Efficacy of HPV-based screening for prevention of invasive cervical cancer: follow-up of four European randomised controlled trials. Lancet 2014; 383 (9916): 524–32. DOI: 10.1016/S0140-6736(13)62218-7
12. Cummings MC, Marquart L, Pelecanos A et al. Which are more correctly diagnosed: conventional Papanicolaou smears or Thinprep samples? A comparative study of 9 years of external quality-assurance testing. Cancer Cytopathol 2015; 123 (2): 108–16. DOI: 10.1002/cncy.21498
13. Novik V.I. Skrining raka shejki matki. Praktich. onkologiya. 2010: 11 (32): 66. [in Russian]
14. Cibas ES, Ducatman BS. Cervical and vaginal cytology. Cytology. Diagnostic principles and clinical correlations. Saunders Elsevier 2009.
15. Cuschieri KS, Wentzensen N. Human papillomavirus mRNA and p16 detections as biomarkers for the improved diagnosis of cervical neoplasia. Cancer Epidemiol Biomarkers Prev 2008; 17 (10): 2536. DOI: 10.1158/1055-9965.EPI-08-0306
16. Benevolo M, Allia E, Gustinucci D et al. Interobserver reproducibility of cytologic p16INK4a/Ki-67 dual immunostaining in human papillomavirus positive women. Cancer Cytopathol 2017; 125 (3): 212–20. DOI: 10.1002/cncy.21800
17. Uijterwaal MH, Polman NJ, Witte BI et al. Triaging HPV-positive women with normal cytology by p16/Ki-67 dual-stained cytology testing: baseline and longitudinal data. Int J Cancer 2015; 136 (10): 2361–8. DOI: 10.1002/ijc.29290
18. Wright TC, Behrensb CM, Ranger-Moorec J et al. Triaging HPV-positive women with p16/Ki-67 dual-stained cytology: results from a sub-study nested into the ATHENA trial. Gynecol Oncol 2017; 144 (1) : 51–6. DOI: 10.1016/j.ygyno.2016.10.031
19. Boulet GA, Horvath CA, Depuydt CE, Bogers JJ. Biomarkers in cervical screening: quantitative reverse transcriptase PCR analysis of P16INK4a expression. Eur J Cancer Prev 2010; 19 (1): 35–41. DOI: 10.1097/CEJ.0b013e32833233d4
20. Cheng JY, Feng MJ, Wu CC et al. Development of a sampling collection device with diagnostic procedures. Anal Chem 2016; 88 (15): 7591–6. DOI: 10.1021/acs.analchem.6b01269
21. Tamalet C, Le Retraite L, Leandri F et al. Vaginal self-sampling is an adequate means of screening HR-HPV types in women not participating in regular cervical cancer screening. Clin Microbiol Infect 2013; 19 (1): 44–50. DOI: 10.1111/1469-0691.12063
22. Verdoodt F, Jentschke M, Hillemanns P et al. Reaching women who do not participate in the regular cervical cancer screening programme by offering self-sampling kits: a systematic review and meta-analysis of randomised trials. Eur J Cancer 2015; 51 (16): 2375–85. DOI: 10.1016/j.ejca.2015.07.006
23. Ortiz AP, Alejandro N, Pérez CM et al. Acceptability of Cervical and Anal HPV Self-sampling in a Sample of Hispanic Women in Puerto Rico. PR Health Sci J 2012; 31 (4): 205–12.
24. Darlin L, Borgfeldt C, Forslund O et al. Comparison of use of vaginal HPV self-sampling and offering flexible appointments as strategies to reach long-term non-attending women in organized cervical screening. J Clin Virol 2013; 58 (1): 155–60. DOI: 10.1016/j.jcv.2013.06.029
25. Karjalainen L, Anttila A, Nieminen P et al. Self-sampling in cervical cancer screening: comparison of a brush-based and a lavage-based cervicovaginal self-sampling device. BMC Cancer 2016; 16: 221. DOI: 10.1186/s12885-016-2246-9
26. Johnson DC, Bhatta MP, Smith JS et al. Assessment of high-risk human papillomavirus infections using clinician- and self-collected cervical sampling methods in rural women from far western Nepal. PLoS One 2014; 9 (6): e101255. DOI: 10.1371/journal.pone.0101255
27. Dijkstra MG, Heideman DA, van Kemenade FJ et al. Brush-based selfsampling in combination with GP5+/6+-PCR-based hrHPV testing: high concordance with physician-taken cervical scrapes for HPV genotyping and detection of high-grade CIN. J Clin Virol 2012; 54 (2): 147–51. DOI: 10.1016/j.jcv.2012.02.022
28. Van Baars R, Bosgraaf RP, ter Harmsel BW et al. Dry storage and transport of a cervicovaginal self-sample by use of the Evalyn Brush, providing reliable human papillomavirus detection combined with comfort for women. J Clin Microbiol 2012; 50 (12): 3937–43. DOI: 10.1016/j.jcv.2012.02.022
29. Gustavsson I, Sanner K, Lindell M et al. Type-specific detection of high-risk human papillomavirus (HPV) in self-sampled cervicovaginal cells applied to FTA elute cartridge. J Clin Virol 2011; 51 (4): 255–8. DOI: 10.1016/j.jcv.2011.05.006
30. Qin Y, Zhang H, Marlowe N et al. Evaluation of human papillomavirus detection by Abbott m2000 system on samples collected by FTA Elute Card in a Chinese HIV-1 positive population. J Clin Virol 2016; 85: 80–5. DOI: 10.1016/j.jcv.2016.11.002
31. Arrossi S, Ramos S, Straw C et al. HPV testing: a mixed-method approach to understand why women prefer self-collection in a middle-income country. BMC Public Health 2016; 16: 832–5. DOI: 10.1186/s12889-016-3474-2
32. Marlow LA, Waller J, Wardle J. Barriers to cervical cancer screening among ethnic minority women: a qualitative study. J Fam Plann Reprod Health Care 2015; 41 (4): 248–54.
33. Zehbe I, Jackson R, Wood B et al. Community-randomised controlled trial embedded in the Anishinaabek Cervical Cancer Screening Study: human papillomavirus self-sampling versus Papanicolaou cytology. BMJ Open 2016; 6 (10): e011754. DOI: 10.1136/bmjopen-2016-011754
34. Belokrinickaya T.E., Frolova N.I., Turanova O.V. i dr. Rezul'tativnost' i priemlemost' obsledovaniya na virus papillomy cheloveka pri samostoyatel'nom i vrachebnom zabore vaginal'nogo otdelyaemogo. Akush. i ginekol. 2017; 2: 97–105. [in Russian]
35. Jentschke M, Soergel P, Hillemanns P. Evaluation of a multiplex real time PCR assay for the detection of human papillomavirus infections on self-collected cervicovaginal lavage samples. J Virol Methods 2013; 193 (1): 131–4. DOI: 10.1016/j.jviromet.2013.05.009

И.А.Аполихина*1, Л.К.Баширова2, Е.А.Горбунова1

1. ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова» Минздрава России. 117997, Россия, Москва, ул. Академика Опарина, д. 4;
2. ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М.Сеченова» Минздрава России. 119991, Россия, Москва, ул. Трубецкая, д. 8, стр. 2
*apolikhina@inbox.ru

________________________________________________

I.A.Apolikhina*1, L.K.Bashirova2, E.A.Gorbunova1

1. V.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Akademika Oparina, d. 4;
2. I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation. 119991, Russian Federation, Moscow, ul. Trubetskaia, d. 8, str. 2
*apolikhina@inbox.ru