Оценка качества жизни женщин при поражениях эпителия шейки матки, ассоциированных с вирусом папилломы человека

Сычева Е.Г., Назарова Н.М., Бурменская О.В., Прилепская В.Н. Оценка качества жизни женщин при поражениях эпителия шейки матки, ассоциированных с вирусом папилломы человека. Гинекология. 2018; 20 (5): 18–21.
DOI: 10.26442/2079-5696_2018.5.18-21

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Sycheva E.G., Nazarova N.M., Burmenskaya O.V., Prilepskaya V.N. Evaluation of health-related quality of life the women with human papillomavirus-associated lesions of the cervical epithelium. Gynecology. 2018; 20 (5): 18–21.
DOI: 10.26442/2079-5696_2018.5.18-21

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Аннотация

Цель исследования – оценить качество жизни (КЖ) женщин с «малыми» формами поражения эпителия шейки матки и пациенток с плоскоклеточными интраэпителиальными поражениями высокой степени тяжести (high grade squamous intraepithelial lesions – HSIL), ассоциированных с вирусом папилломы человека (ВПЧ) высокого риска.
Материалы и методы. В исследовании приняли участие 274 женщины репродуктивного возраста, разделенные на две основные группы: женщины с ВПЧ-инфекцией («малые» формы поражения – 202 пациентки и с HSIL – 20) и здоровые женщины – 20. Всем исследуемым женщинам проведено анкетирование с использованием опросника EQ-5D-5L.
Результаты. Выявлено достоверное снижение КЖ на уровне психологического и эмоционального компонентов у пациенток групп с «малыми» формами поражения эпителия шейки матки и HSIL (р<0,005).
Выводы. В большинстве случаев у пациенток с ВПЧ-инфекцией был задействован психологический компонент КЖ, оказывающий влияние на их общее благополучие.

Ключевые слова: вирус папилломы человека высокого канцерогенного риска, рак шейки матки, опросник EQ-5D-5L, цервикальные интраэпителиальные неоплазии, «малые» формы поражения.

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Objective – to evaluate the health-related Quality of life the women with “lesser” abnormalities of cervical epithelium and patients with high grade squamous intraepithelial lesions (HSIL) associated with human papillomavirus (HPV) infection.
Materials and methods. The investigation was performed 274 women of reproductive age, divided into two main groups: HPV infection (“lesser” abnormalities 202 patients and with HSIL – 20) and healthy women – 20. All the studied women of health-related quality of life by using the EQ-5D-5L.
Results. Revealed a significant reduction in the level of health-related quality of life in the psychological and emotional components of the patients with “lesser” abnormalities of cervical epithelium and patients with HSIL associated with HPV infection (p<0.005).
Conclusions. In most cases, patients with HPV infection was involved psychological component of health-related quality of life, anxiety, fear of further fertility affects the overall well-being of patients.

Key words: human papillomavirus high cancerogenic risk, cervical cancer, questionnaire EQ-5D -5L, cervical intraepithelial neoplasia, “lesser” abnormalities.

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Список литературы

1. Waxman AG, Chelmow D, Darragh TM et al. Revised Terminology for Cervical Histopathology and Its Implications for Management of High-Grade Squamous Intraepithelial Lesions of the Cervix. Obstet Gynecol 2012; 120 (6): 1465–71.
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5. Whynes DK, Sharp L, Cotton SC et al. Impact of alternative management policies on health-related quality of life in women with low-grade abnormal cervical cytology referred for colposcopy. Eur J Obstet Gynecol Reprod Biol 2013; 169 (1): 88–92.
6. Marcellusi A, Capone A, Favato G et al. Health utilities lost and risk factors associated with HPV-induced diseases in men and women: the HPV Italian collaborative study group. Clin Ther 2015; 37 (1): 156–67.
7. Zhi-Mei Zhao, Xiong-Fei Pan, Si-Han L et al. Quality of life in women with cervical precursor lesions and cancer: a prospective, 6-month, hospital-based study in China. Chin J Cancer 2014; 33 (7): 339–45.
8. Lang HC, Chuang L, Shun SC et al. Validation of EQ-5D in patients with cervical cancer in Taiwan. Support Care Cancer 2010; 18: 1279–86.
9. Endarti D, Riewpaiboon A, Thavorncharoensap M et al. Evaluation of Health-Related Quality of Life among Patients with Cervical Cancer in Indonesia. Asian Pac J Cancer Prev 2015; 16 (8): 3345–50.
10. Bertram CC, Magnussen L. Informational needs and the experiences of women with abnormal Papanicolaou smears. J Am Acad Nurse Pract 2008; 20 (9): 55–62.
11. Waller J, McCaffery K, Kitchner H et al. Women’s ex-periences of repeated HPV testing in the context of cervical cancer screening: a qualitative study. Psycho-Oncology 2007; 16: 196–204.

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1. Waxman AG, Chelmow D, Darragh TM et al. Revised Terminology for Cervical Histopathology and Its Implications for Management of High-Grade Squamous Intraepithelial Lesions of the Cervix. Obstet Gynecol 2012; 120 (6): 1465–71.
2. Novik A.A., Ionova T.I., Kaind P. Kontseptsiia issledovaniia kachestva zhizni v meditsine. SPb.: Elbi, 1999. [in Russian]
3. Rabin R, de Charro F. EQ-5D: a measure of health status from the EuroQol Group. Ann Med 2001; 33: 337–43.
4. Whynes DK. Does the correspondence between EQ-5D health state description and VAS score vary by medical condition? Health Qual Life Outcomes 2013; 13 (11): 155.
5. Whynes DK, Sharp L, Cotton SC et al. Impact of alternative management policies on health-related quality of life in women with low-grade abnormal cervical cytology referred for colposcopy. Eur J Obstet Gynecol Reprod Biol 2013; 169 (1): 88–92.
6. Marcellusi A, Capone A, Favato G et al. Health utilities lost and risk factors associated with HPV-induced diseases in men and women: the HPV Italian collaborative study group. Clin Ther 2015; 37 (1): 156–67.
7. Zhi-Mei Zhao, Xiong-Fei Pan, Si-Han L et al. Quality of life in women with cervical precursor lesions and cancer: a prospective, 6-month, hospital-based study in China. Chin J Cancer 2014; 33 (7): 339–45.
8. Lang HC, Chuang L, Shun SC et al. Validation of EQ-5D in patients with cervical cancer in Taiwan. Support Care Cancer 2010; 18: 1279–86.
9. Endarti D, Riewpaiboon A, Thavorncharoensap M et al. Evaluation of Health-Related Quality of Life among Patients with Cervical Cancer in Indonesia. Asian Pac J Cancer Prev 2015; 16 (8): 3345–50.
10. Bertram CC, Magnussen L. Informational needs and the experiences of women with abnormal Papanicolaou smears. J Am Acad Nurse Pract 2008; 20 (9): 55–62.
11. Waller J, McCaffery K, Kitchner H et al. Women’s ex-periences of repeated HPV testing in the context of cervical cancer screening: a qualitative study. Psycho-Oncology 2007; 16: 196–204.

Авторы

Е.Г.Сычева*, Н.М.Назарова, О.В.Бурменская, В.Н.Прилепская

ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. В.И.Кулакова» Минздрава России. 117997, Россия, Москва, ул. Академика Опарина, д. 4
*el.bona@mail.ru

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E.G.Sycheva*, N.M.Nazarova, O.V.Burmenskaya, V.N.Prilepskaya

V.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Akademika Oparina, d. 4
*el.bona@mail.ru

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