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Оценка качества жизни женщин при поражениях эпителия шейки матки, ассоциированных с вирусом папилломы человека
Оценка качества жизни женщин при поражениях эпителия шейки матки, ассоциированных с вирусом папилломы человека
Сычева Е.Г., Назарова Н.М., Бурменская О.В., Прилепская В.Н. Оценка качества жизни женщин при поражениях эпителия шейки матки, ассоциированных с вирусом папилломы человека. Гинекология. 2018; 20 (5): 18–21.
DOI: 10.26442/2079-5696_2018.5.18-21
DOI: 10.26442/2079-5696_2018.5.18-21
DOI: 10.26442/2079-5696_2018.5.18-21
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DOI: 10.26442/2079-5696_2018.5.18-21
Материалы доступны только для специалистов сферы здравоохранения. Авторизуйтесь или зарегистрируйтесь.
Аннотация
Цель исследования – оценить качество жизни (КЖ) женщин с «малыми» формами поражения эпителия шейки матки и пациенток с плоскоклеточными интраэпителиальными поражениями высокой степени тяжести (high grade squamous intraepithelial lesions – HSIL), ассоциированных с вирусом папилломы человека (ВПЧ) высокого риска.
Материалы и методы. В исследовании приняли участие 274 женщины репродуктивного возраста, разделенные на две основные группы: женщины с ВПЧ-инфекцией («малые» формы поражения – 202 пациентки и с HSIL – 20) и здоровые женщины – 20. Всем исследуемым женщинам проведено анкетирование с использованием опросника EQ-5D-5L.
Результаты. Выявлено достоверное снижение КЖ на уровне психологического и эмоционального компонентов у пациенток групп с «малыми» формами поражения эпителия шейки матки и HSIL (р<0,005).
Выводы. В большинстве случаев у пациенток с ВПЧ-инфекцией был задействован психологический компонент КЖ, оказывающий влияние на их общее благополучие.
Ключевые слова: вирус папилломы человека высокого канцерогенного риска, рак шейки матки, опросник EQ-5D-5L, цервикальные интраэпителиальные неоплазии, «малые» формы поражения.
Materials and methods. The investigation was performed 274 women of reproductive age, divided into two main groups: HPV infection (“lesser” abnormalities 202 patients and with HSIL – 20) and healthy women – 20. All the studied women of health-related quality of life by using the EQ-5D-5L.
Results. Revealed a significant reduction in the level of health-related quality of life in the psychological and emotional components of the patients with “lesser” abnormalities of cervical epithelium and patients with HSIL associated with HPV infection (p<0.005).
Conclusions. In most cases, patients with HPV infection was involved psychological component of health-related quality of life, anxiety, fear of further fertility affects the overall well-being of patients.
Key words: human papillomavirus high cancerogenic risk, cervical cancer, questionnaire EQ-5D -5L, cervical intraepithelial neoplasia, “lesser” abnormalities.
Материалы и методы. В исследовании приняли участие 274 женщины репродуктивного возраста, разделенные на две основные группы: женщины с ВПЧ-инфекцией («малые» формы поражения – 202 пациентки и с HSIL – 20) и здоровые женщины – 20. Всем исследуемым женщинам проведено анкетирование с использованием опросника EQ-5D-5L.
Результаты. Выявлено достоверное снижение КЖ на уровне психологического и эмоционального компонентов у пациенток групп с «малыми» формами поражения эпителия шейки матки и HSIL (р<0,005).
Выводы. В большинстве случаев у пациенток с ВПЧ-инфекцией был задействован психологический компонент КЖ, оказывающий влияние на их общее благополучие.
Ключевые слова: вирус папилломы человека высокого канцерогенного риска, рак шейки матки, опросник EQ-5D-5L, цервикальные интраэпителиальные неоплазии, «малые» формы поражения.
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Materials and methods. The investigation was performed 274 women of reproductive age, divided into two main groups: HPV infection (“lesser” abnormalities 202 patients and with HSIL – 20) and healthy women – 20. All the studied women of health-related quality of life by using the EQ-5D-5L.
Results. Revealed a significant reduction in the level of health-related quality of life in the psychological and emotional components of the patients with “lesser” abnormalities of cervical epithelium and patients with HSIL associated with HPV infection (p<0.005).
Conclusions. In most cases, patients with HPV infection was involved psychological component of health-related quality of life, anxiety, fear of further fertility affects the overall well-being of patients.
Key words: human papillomavirus high cancerogenic risk, cervical cancer, questionnaire EQ-5D -5L, cervical intraepithelial neoplasia, “lesser” abnormalities.
Полный текст
Список литературы
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2. Новик А.А., Ионова Т.И., Кайнд П. Концепция исследования качества жизни в медицине. СПб.: Элби, 1999. / Novik A.A., Ionova T.I., Kaind P. Kontseptsiia issledovaniia kachestva zhizni v meditsine. SPb.: Elbi, 1999. [in Russian]
3. Rabin R, de Charro F. EQ-5D: a measure of health status from the EuroQol Group. Ann Med 2001; 33: 337–43.
4. Whynes DK. Does the correspondence between EQ-5D health state description and VAS score vary by medical condition? Health Qual Life Outcomes 2013; 13 (11): 155.
5. Whynes DK, Sharp L, Cotton SC et al. Impact of alternative management policies on health-related quality of life in women with low-grade abnormal cervical cytology referred for colposcopy. Eur J Obstet Gynecol Reprod Biol 2013; 169 (1): 88–92.
6. Marcellusi A, Capone A, Favato G et al. Health utilities lost and risk factors associated with HPV-induced diseases in men and women: the HPV Italian collaborative study group. Clin Ther 2015; 37 (1): 156–67.
7. Zhi-Mei Zhao, Xiong-Fei Pan, Si-Han L et al. Quality of life in women with cervical precursor lesions and cancer: a prospective, 6-month, hospital-based study in China. Chin J Cancer 2014; 33 (7): 339–45.
8. Lang HC, Chuang L, Shun SC et al. Validation of EQ-5D in patients with cervical cancer in Taiwan. Support Care Cancer 2010; 18: 1279–86.
9. Endarti D, Riewpaiboon A, Thavorncharoensap M et al. Evaluation of Health-Related Quality of Life among Patients with Cervical Cancer in Indonesia. Asian Pac J Cancer Prev 2015; 16 (8): 3345–50.
10. Bertram CC, Magnussen L. Informational needs and the experiences of women with abnormal Papanicolaou smears. J Am Acad Nurse Pract 2008; 20 (9): 55–62.
11. Waller J, McCaffery K, Kitchner H et al. Women’s ex-periences of repeated HPV testing in the context of cervical cancer screening: a qualitative study. Psycho-Oncology 2007; 16: 196–204.
2. Novik A.A., Ionova T.I., Kaind P. Kontseptsiia issledovaniia kachestva zhizni v meditsine. SPb.: Elbi, 1999. [in Russian]
3. Rabin R, de Charro F. EQ-5D: a measure of health status from the EuroQol Group. Ann Med 2001; 33: 337–43.
4. Whynes DK. Does the correspondence between EQ-5D health state description and VAS score vary by medical condition? Health Qual Life Outcomes 2013; 13 (11): 155.
5. Whynes DK, Sharp L, Cotton SC et al. Impact of alternative management policies on health-related quality of life in women with low-grade abnormal cervical cytology referred for colposcopy. Eur J Obstet Gynecol Reprod Biol 2013; 169 (1): 88–92.
6. Marcellusi A, Capone A, Favato G et al. Health utilities lost and risk factors associated with HPV-induced diseases in men and women: the HPV Italian collaborative study group. Clin Ther 2015; 37 (1): 156–67.
7. Zhi-Mei Zhao, Xiong-Fei Pan, Si-Han L et al. Quality of life in women with cervical precursor lesions and cancer: a prospective, 6-month, hospital-based study in China. Chin J Cancer 2014; 33 (7): 339–45.
8. Lang HC, Chuang L, Shun SC et al. Validation of EQ-5D in patients with cervical cancer in Taiwan. Support Care Cancer 2010; 18: 1279–86.
9. Endarti D, Riewpaiboon A, Thavorncharoensap M et al. Evaluation of Health-Related Quality of Life among Patients with Cervical Cancer in Indonesia. Asian Pac J Cancer Prev 2015; 16 (8): 3345–50.
10. Bertram CC, Magnussen L. Informational needs and the experiences of women with abnormal Papanicolaou smears. J Am Acad Nurse Pract 2008; 20 (9): 55–62.
11. Waller J, McCaffery K, Kitchner H et al. Women’s ex-periences of repeated HPV testing in the context of cervical cancer screening: a qualitative study. Psycho-Oncology 2007; 16: 196–204.
2. Новик А.А., Ионова Т.И., Кайнд П. Концепция исследования качества жизни в медицине. СПб.: Элби, 1999. / Novik A.A., Ionova T.I., Kaind P. Kontseptsiia issledovaniia kachestva zhizni v meditsine. SPb.: Elbi, 1999. [in Russian]
3. Rabin R, de Charro F. EQ-5D: a measure of health status from the EuroQol Group. Ann Med 2001; 33: 337–43.
4. Whynes DK. Does the correspondence between EQ-5D health state description and VAS score vary by medical condition? Health Qual Life Outcomes 2013; 13 (11): 155.
5. Whynes DK, Sharp L, Cotton SC et al. Impact of alternative management policies on health-related quality of life in women with low-grade abnormal cervical cytology referred for colposcopy. Eur J Obstet Gynecol Reprod Biol 2013; 169 (1): 88–92.
6. Marcellusi A, Capone A, Favato G et al. Health utilities lost and risk factors associated with HPV-induced diseases in men and women: the HPV Italian collaborative study group. Clin Ther 2015; 37 (1): 156–67.
7. Zhi-Mei Zhao, Xiong-Fei Pan, Si-Han L et al. Quality of life in women with cervical precursor lesions and cancer: a prospective, 6-month, hospital-based study in China. Chin J Cancer 2014; 33 (7): 339–45.
8. Lang HC, Chuang L, Shun SC et al. Validation of EQ-5D in patients with cervical cancer in Taiwan. Support Care Cancer 2010; 18: 1279–86.
9. Endarti D, Riewpaiboon A, Thavorncharoensap M et al. Evaluation of Health-Related Quality of Life among Patients with Cervical Cancer in Indonesia. Asian Pac J Cancer Prev 2015; 16 (8): 3345–50.
10. Bertram CC, Magnussen L. Informational needs and the experiences of women with abnormal Papanicolaou smears. J Am Acad Nurse Pract 2008; 20 (9): 55–62.
11. Waller J, McCaffery K, Kitchner H et al. Women’s ex-periences of repeated HPV testing in the context of cervical cancer screening: a qualitative study. Psycho-Oncology 2007; 16: 196–204.
________________________________________________
2. Novik A.A., Ionova T.I., Kaind P. Kontseptsiia issledovaniia kachestva zhizni v meditsine. SPb.: Elbi, 1999. [in Russian]
3. Rabin R, de Charro F. EQ-5D: a measure of health status from the EuroQol Group. Ann Med 2001; 33: 337–43.
4. Whynes DK. Does the correspondence between EQ-5D health state description and VAS score vary by medical condition? Health Qual Life Outcomes 2013; 13 (11): 155.
5. Whynes DK, Sharp L, Cotton SC et al. Impact of alternative management policies on health-related quality of life in women with low-grade abnormal cervical cytology referred for colposcopy. Eur J Obstet Gynecol Reprod Biol 2013; 169 (1): 88–92.
6. Marcellusi A, Capone A, Favato G et al. Health utilities lost and risk factors associated with HPV-induced diseases in men and women: the HPV Italian collaborative study group. Clin Ther 2015; 37 (1): 156–67.
7. Zhi-Mei Zhao, Xiong-Fei Pan, Si-Han L et al. Quality of life in women with cervical precursor lesions and cancer: a prospective, 6-month, hospital-based study in China. Chin J Cancer 2014; 33 (7): 339–45.
8. Lang HC, Chuang L, Shun SC et al. Validation of EQ-5D in patients with cervical cancer in Taiwan. Support Care Cancer 2010; 18: 1279–86.
9. Endarti D, Riewpaiboon A, Thavorncharoensap M et al. Evaluation of Health-Related Quality of Life among Patients with Cervical Cancer in Indonesia. Asian Pac J Cancer Prev 2015; 16 (8): 3345–50.
10. Bertram CC, Magnussen L. Informational needs and the experiences of women with abnormal Papanicolaou smears. J Am Acad Nurse Pract 2008; 20 (9): 55–62.
11. Waller J, McCaffery K, Kitchner H et al. Women’s ex-periences of repeated HPV testing in the context of cervical cancer screening: a qualitative study. Psycho-Oncology 2007; 16: 196–204.
Авторы
Е.Г.Сычева*, Н.М.Назарова, О.В.Бурменская, В.Н.Прилепская
ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. В.И.Кулакова» Минздрава России. 117997, Россия, Москва, ул. Академика Опарина, д. 4
*el.bona@mail.ru
V.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Akademika Oparina, d. 4
*el.bona@mail.ru
ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. В.И.Кулакова» Минздрава России. 117997, Россия, Москва, ул. Академика Опарина, д. 4
*el.bona@mail.ru
________________________________________________
V.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Akademika Oparina, d. 4
*el.bona@mail.ru
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