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Пузырный занос: клинический случай ведения беременности
Пузырный занос: клинический случай ведения беременности
Доброхотова Ю.Э., Аракелов С.Э., Данелян С.Ж. и др. Пузырный занос: клинический случай ведения беременности. Гинекология. 2019; 21 (2): 28–33.
DOI: 10.26442/20795696.2019.2.190347
DOI: 10.26442/20795696.2019.2.190347
DOI: 10.26442/20795696.2019.2.190347
________________________________________________
DOI: 10.26442/20795696.2019.2.190347
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Чтобы посмотреть материал полностью
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Аннотация
Пузырный занос (ПЗ) представляет собой заболевание из ткани трофобласта с сохраненным пролиферативным потенциалом и развивается после аберрантного оплодотворения. Для полного ПЗ характерны быстрое увеличение размеров матки, значительное повышение уровня b-хорионического гонадотропина человека (ХГЧ), кровотечение, симптомы гипертиреоза, тяжелое течение рвоты беременных и раннее развитие преэклампсии. Текалютеиновые кисты формируются в яичниках в результате воздействия высоких титров ХГЧ и пролактина. Многоплодная беременность может осложняться развитием полного и частичного ПЗ у одного из плодов в одном случае на 20 000–100 000 беременностей. В статье представлен клинический случай сопровождения беременной 32 лет с бихориальной биамниотической двойней и полным ПЗ одного плода. Беременность наступила спонтанно, протекала с угрозой прерывания до 12 нед, угрожающими преждевременными родами, преэклампсией с 24 нед. Пациентка была родоразрешена в 28 нед в связи с тяжелой преэклампсией, рождена живая недоношенная девочка массой 1030 г, ростом 33 см с оценкой по шкале Апгар 6/7 баллов. На 40-е сутки после родов уровень b-ХГЧ отрицательный.
Ключевые слова: пузырный занос, трофобластическая болезнь, многоплодная беременность, хорионический гонадотропин, преэклампсия, текалютеиновые кисты.
Key words: hydatidiform mole, trophoblastic disease, multiple pregnancy, chorionic gonadotropin, preeclampsia, thecalutein cysts.
Ключевые слова: пузырный занос, трофобластическая болезнь, многоплодная беременность, хорионический гонадотропин, преэклампсия, текалютеиновые кисты.
________________________________________________
Key words: hydatidiform mole, trophoblastic disease, multiple pregnancy, chorionic gonadotropin, preeclampsia, thecalutein cysts.
Полный текст
Список литературы
1. Berkowitz RS, Goldstein DP. Current advances in the management of gestational trophoblastic disease. Gynecol Oncol 2013; 128: 3.
2. Altieri A, Franceschi S, Ferlay J et al. Epidemiology and aetiology of gestational trophoblastic diseases. Lancet Oncol 2003; 4: 670.
3. Azuma C, Saji F, Tokugawa Y et al. Application of gene amplification by polymerase chain reaction to genetic analysis of molar mitochondrial DNA: the detection of anuclear empty ovum as the cause of complete mole. Gynecol Oncol 1991; 40: 29.
4. Szulman AE, Surti U. The syndromes of hydatidiform mole. I. Cytogenetic and morphologic correlations. Am J Obstet Gynecol 1978; 131: 665.
5. Melamed A, Gockley AA, Joseph NT et al. Effect of race/ethnicity on risk of complete and partial molar pregnancy after adjustment for age. Gynecol Oncol 2016; 143: 73.
6. Vargas R, Barroilhet LM, Esselen K et al. Subsequent pregnancy outcomes after complete and partial molar pregnancy, recurrent molar pregnancy, and gestational trophoblastic neoplasia: an update from the New England Trophoblastic Disease Center. J Reprod Med 2014; 59: 188.
7. Hershman JM. Physiological and pathological aspects of the effect of human chorionic gonadotropin on the thyroid. Best Pract Res Clin Endocrinol Metab 2004; 18: 249.
8. Braga A, Moraes V, Maestá I et al. Changing Trends in the Clinical Presentation and Management of Complete Hydatidiform Mole Among Brazilian Women. Int J Gynecol Cancer 2016; 26: 984.
9. Committee on Practice Bulletins-Gynecology, American College of Obstetricians and Gynecologists. ACOG Practice Bulletin #53. Diagnosis and treatment of gestational trophoblastic disease. Obstet Gynecol 2004; 103: 1365.
10. Benson CB, Genest DR, Bernstein MR et al. Sonographic appearance of first trimester complete hydatidiform moles. Ultrasound Obstet Gynecol 2000; 16: 188.
11. Fowler DJ, Lindsay I, Seckl MJ, Sebire NJ. Routine pre-evacuation ultrasound diagnosis of hydatidiform mole: experience of more than 1000 cases from a regional referral center. Ultrasound Obstet Gynecol 2006; 27: 56.
12. Seckin KD, Baser E, Yeral I et al. The impact of ultrasonographic lesion size and initial human chorionic gonadotropin values on treatment success in cases with complete hydatidiform mole. Eur Rev Med Pharmacol Sci 2013; 17: 3381.
13. Niemann I, Hansen ES, Sunde L. The risk of persistent trophoblastic disease after hydatidiform mole classified by morphology and ploidy. Gynecol Oncol 2007; 104: 411.
14. Shazly SA, Ali MK, Abdel Badee AY et al. Twin pregnancy with complete hydatidiform mole and coexisting fetus following ovulation induction with a non-prescribed clomiphene citrate regimen: a case report. J Med Case Rep 2012; 6: 95.
15. Hancock BW, Nazir K, Everard JE. Persistent gestational trophoblastic neoplasia after partial hydatidiform mole incidence and outcome. J Reprod Med 2006; 51: 764.
16. Massardier J, Golfier F, Journet D et al. Twin pregnancy with complete hydatidiform mole and coexistent fetus: obstetrical and oncological outcomes in a series of 14 cases. Eur J Obstet Gynecol Reprod Biol 2009; 143: 84.
17. Niemann L, Fisher R, Sebire NJ et al. Update on UK outcomes for women with twin pregnancies comprising a complete hydatidiform mole and normal co-twin. XVII World Congress on Gestational Trophoblastic Disease. 2013; p. 57 (abstract).
18. Steller MA, Genest DR, Bernstein MR et al. Clinical features of multiple conception with partial or complete molar pregnancy and coexisting fetuses. J Reprod Med 1994; 39: 147.
19. Lin LH, Maestá I, Braga A et al. Multiple pregnancies with complete mole and coexisting normal fetus in North and South America: A retrospective multicenter cohort and literature review. Gynecol Oncol 2017; 145: 88.
20. Matsui H, Sekiya S, Hando T et al. Hydatidiform mole coexistent with a twin live fetus: a national collaborative study in Japan. Hum Reprod 2000; 15: 608.
21. Tidy JA, Gillespie AM, Bright N et al. Gestational trophoblastic disease: a study of mode of evacuation and subsequent need for treatment with chemotherapy. Gynecol Oncol 2000; 78: 309.
22. Tse KY, Chan KK, Tam KF, Ngan HY. 20-year experience of managing profuse bleeding in gestational trophoblastic disease. J Reprod Med 2007; 52: 397.
23. Elias KM, Shoni M, Bernstein M et al. Complete hydatidiform mole in women aged 40 to 49 years. J Reprod Med 2012; 57: 254.
24. Elias KM, Goldstein DP, Berkowitz RS. Complete hydatidiform mole in women older than age 50. J Reprod Med 2010; 55: 208.
25. Fu J, Fang F, Xie L et al. Prophylactic chemotherapy for hydatidiform mole to prevent gestational trophoblastic neoplasia. Cochrane Database Syst Rev 2012; 10: CD007289.
26. Limpongsanurak S. Prophylactic actinomycin D for high-risk complete hydatidiform mole. J Reprod Med 2001; 46: 110.
27. FIGO Committee on Gynecologic Oncology. Current FIGO staging for cancer of the vagina, fallopian tube, ovary, and gestational trophoblastic neoplasia. Int J Gynaecol Obstet 2009; 105: 3.
28. Adewole IF, Oladokun A, Fawole AO et al. Fertility regulatory methods and development of complications after evacuation of complete hydatidiform mole. J Obstet Gynaecol 2000; 20: 68.
29. Feltmate CM, Growdon WB, Wolfberg AJ et al. Clinical characteristics of persistent gestational trophoblastic neoplasia after partial hydatidiform molar pregnancy. J Reprod Med 2006; 51: 902.
30. Vargas R, Barroilhet LM, Esselen K et al. Subsequent pregnancy outcomes after complete and partial molar pregnancy, recurrent molar pregnancy, and gestational trophoblastic neoplasia: an update from the New England Trophoblastic Disease Center. J Reprod Med 2014; 59: 188.
31. Sebire NJ, Fisher RA, Foskett M et al. Risk of recurrent hydatidiform mole and subsequent pregnancy outcome following complete or partial hydatidiform molar pregnancy. BJOG 2003; 110:
2. Altieri A, Franceschi S, Ferlay J et al. Epidemiology and aetiology of gestational trophoblastic diseases. Lancet Oncol 2003; 4: 670.
3. Azuma C, Saji F, Tokugawa Y et al. Application of gene amplification by polymerase chain reaction to genetic analysis of molar mitochondrial DNA: the detection of anuclear empty ovum as the cause of complete mole. Gynecol Oncol 1991; 40: 29.
4. Szulman AE, Surti U. The syndromes of hydatidiform mole. I. Cytogenetic and morphologic correlations. Am J Obstet Gynecol 1978; 131: 665.
5. Melamed A, Gockley AA, Joseph NT et al. Effect of race/ethnicity on risk of complete and partial molar pregnancy after adjustment for age. Gynecol Oncol 2016; 143: 73.
6. Vargas R, Barroilhet LM, Esselen K et al. Subsequent pregnancy outcomes after complete and partial molar pregnancy, recurrent molar pregnancy, and gestational trophoblastic neoplasia: an update from the New England Trophoblastic Disease Center. J Reprod Med 2014; 59: 188.
7. Hershman JM. Physiological and pathological aspects of the effect of human chorionic gonadotropin on the thyroid. Best Pract Res Clin Endocrinol Metab 2004; 18: 249.
8. Braga A, Moraes V, Maestá I et al. Changing Trends in the Clinical Presentation and Management of Complete Hydatidiform Mole Among Brazilian Women. Int J Gynecol Cancer 2016; 26: 984.
9. Committee on Practice Bulletins-Gynecology, American College of Obstetricians and Gynecologists. ACOG Practice Bulletin #53. Diagnosis and treatment of gestational trophoblastic disease. Obstet Gynecol 2004; 103: 1365.
10. Benson CB, Genest DR, Bernstein MR et al. Sonographic appearance of first trimester complete hydatidiform moles. Ultrasound Obstet Gynecol 2000; 16: 188.
11. Fowler DJ, Lindsay I, Seckl MJ, Sebire NJ. Routine pre-evacuation ultrasound diagnosis of hydatidiform mole: experience of more than 1000 cases from a regional referral center. Ultrasound Obstet Gynecol 2006; 27: 56.
12. Seckin KD, Baser E, Yeral I et al. The impact of ultrasonographic lesion size and initial human chorionic gonadotropin values on treatment success in cases with complete hydatidiform mole. Eur Rev Med Pharmacol Sci 2013; 17: 3381.
13. Niemann I, Hansen ES, Sunde L. The risk of persistent trophoblastic disease after hydatidiform mole classified by morphology and ploidy. Gynecol Oncol 2007; 104: 411.
14. Shazly SA, Ali MK, Abdel Badee AY et al. Twin pregnancy with complete hydatidiform mole and coexisting fetus following ovulation induction with a non-prescribed clomiphene citrate regimen: a case report. J Med Case Rep 2012; 6: 95.
15. Hancock BW, Nazir K, Everard JE. Persistent gestational trophoblastic neoplasia after partial hydatidiform mole incidence and outcome. J Reprod Med 2006; 51: 764.
16. Massardier J, Golfier F, Journet D et al. Twin pregnancy with complete hydatidiform mole and coexistent fetus: obstetrical and oncological outcomes in a series of 14 cases. Eur J Obstet Gynecol Reprod Biol 2009; 143: 84.
17. Niemann L, Fisher R, Sebire NJ et al. Update on UK outcomes for women with twin pregnancies comprising a complete hydatidiform mole and normal co-twin. XVII World Congress on Gestational Trophoblastic Disease. 2013; p. 57 (abstract).
18. Steller MA, Genest DR, Bernstein MR et al. Clinical features of multiple conception with partial or complete molar pregnancy and coexisting fetuses. J Reprod Med 1994; 39: 147.
19. Lin LH, Maestá I, Braga A et al. Multiple pregnancies with complete mole and coexisting normal fetus in North and South America: A retrospective multicenter cohort and literature review. Gynecol Oncol 2017; 145: 88.
20. Matsui H, Sekiya S, Hando T et al. Hydatidiform mole coexistent with a twin live fetus: a national collaborative study in Japan. Hum Reprod 2000; 15: 608.
21. Tidy JA, Gillespie AM, Bright N et al. Gestational trophoblastic disease: a study of mode of evacuation and subsequent need for treatment with chemotherapy. Gynecol Oncol 2000; 78: 309.
22. Tse KY, Chan KK, Tam KF, Ngan HY. 20-year experience of managing profuse bleeding in gestational trophoblastic disease. J Reprod Med 2007; 52: 397.
23. Elias KM, Shoni M, Bernstein M et al. Complete hydatidiform mole in women aged 40 to 49 years. J Reprod Med 2012; 57: 254.
24. Elias KM, Goldstein DP, Berkowitz RS. Complete hydatidiform mole in women older than age 50. J Reprod Med 2010; 55: 208.
25. Fu J, Fang F, Xie L et al. Prophylactic chemotherapy for hydatidiform mole to prevent gestational trophoblastic neoplasia. Cochrane Database Syst Rev 2012; 10: CD007289.
26. Limpongsanurak S. Prophylactic actinomycin D for high-risk complete hydatidiform mole. J Reprod Med 2001; 46: 110.
27. FIGO Committee on Gynecologic Oncology. Current FIGO staging for cancer of the vagina, fallopian tube, ovary, and gestational trophoblastic neoplasia. Int J Gynaecol Obstet 2009; 105: 3.
28. Adewole IF, Oladokun A, Fawole AO et al. Fertility regulatory methods and development of complications after evacuation of complete hydatidiform mole. J Obstet Gynaecol 2000; 20: 68.
29. Feltmate CM, Growdon WB, Wolfberg AJ et al. Clinical characteristics of persistent gestational trophoblastic neoplasia after partial hydatidiform molar pregnancy. J Reprod Med 2006; 51: 902.
30. Vargas R, Barroilhet LM, Esselen K et al. Subsequent pregnancy outcomes after complete and partial molar pregnancy, recurrent molar pregnancy, and gestational trophoblastic neoplasia: an update from the New England Trophoblastic Disease Center. J Reprod Med 2014; 59: 188.
31. Sebire NJ, Fisher RA, Foskett M et al. Risk of recurrent hydatidiform mole and subsequent pregnancy outcome following complete or partial hydatidiform molar pregnancy. BJOG 2003; 110:
2. Altieri A, Franceschi S, Ferlay J et al. Epidemiology and aetiology of gestational trophoblastic diseases. Lancet Oncol 2003; 4: 670.
3. Azuma C, Saji F, Tokugawa Y et al. Application of gene amplification by polymerase chain reaction to genetic analysis of molar mitochondrial DNA: the detection of anuclear empty ovum as the cause of complete mole. Gynecol Oncol 1991; 40: 29.
4. Szulman AE, Surti U. The syndromes of hydatidiform mole. I. Cytogenetic and morphologic correlations. Am J Obstet Gynecol 1978; 131: 665.
5. Melamed A, Gockley AA, Joseph NT et al. Effect of race/ethnicity on risk of complete and partial molar pregnancy after adjustment for age. Gynecol Oncol 2016; 143: 73.
6. Vargas R, Barroilhet LM, Esselen K et al. Subsequent pregnancy outcomes after complete and partial molar pregnancy, recurrent molar pregnancy, and gestational trophoblastic neoplasia: an update from the New England Trophoblastic Disease Center. J Reprod Med 2014; 59: 188.
7. Hershman JM. Physiological and pathological aspects of the effect of human chorionic gonadotropin on the thyroid. Best Pract Res Clin Endocrinol Metab 2004; 18: 249.
8. Braga A, Moraes V, Maestá I et al. Changing Trends in the Clinical Presentation and Management of Complete Hydatidiform Mole Among Brazilian Women. Int J Gynecol Cancer 2016; 26: 984.
9. Committee on Practice Bulletins-Gynecology, American College of Obstetricians and Gynecologists. ACOG Practice Bulletin #53. Diagnosis and treatment of gestational trophoblastic disease. Obstet Gynecol 2004; 103: 1365.
10. Benson CB, Genest DR, Bernstein MR et al. Sonographic appearance of first trimester complete hydatidiform moles. Ultrasound Obstet Gynecol 2000; 16: 188.
11. Fowler DJ, Lindsay I, Seckl MJ, Sebire NJ. Routine pre-evacuation ultrasound diagnosis of hydatidiform mole: experience of more than 1000 cases from a regional referral center. Ultrasound Obstet Gynecol 2006; 27: 56.
12. Seckin KD, Baser E, Yeral I et al. The impact of ultrasonographic lesion size and initial human chorionic gonadotropin values on treatment success in cases with complete hydatidiform mole. Eur Rev Med Pharmacol Sci 2013; 17: 3381.
13. Niemann I, Hansen ES, Sunde L. The risk of persistent trophoblastic disease after hydatidiform mole classified by morphology and ploidy. Gynecol Oncol 2007; 104: 411.
14. Shazly SA, Ali MK, Abdel Badee AY et al. Twin pregnancy with complete hydatidiform mole and coexisting fetus following ovulation induction with a non-prescribed clomiphene citrate regimen: a case report. J Med Case Rep 2012; 6: 95.
15. Hancock BW, Nazir K, Everard JE. Persistent gestational trophoblastic neoplasia after partial hydatidiform mole incidence and outcome. J Reprod Med 2006; 51: 764.
16. Massardier J, Golfier F, Journet D et al. Twin pregnancy with complete hydatidiform mole and coexistent fetus: obstetrical and oncological outcomes in a series of 14 cases. Eur J Obstet Gynecol Reprod Biol 2009; 143: 84.
17. Niemann L, Fisher R, Sebire NJ et al. Update on UK outcomes for women with twin pregnancies comprising a complete hydatidiform mole and normal co-twin. XVII World Congress on Gestational Trophoblastic Disease. 2013; p. 57 (abstract).
18. Steller MA, Genest DR, Bernstein MR et al. Clinical features of multiple conception with partial or complete molar pregnancy and coexisting fetuses. J Reprod Med 1994; 39: 147.
19. Lin LH, Maestá I, Braga A et al. Multiple pregnancies with complete mole and coexisting normal fetus in North and South America: A retrospective multicenter cohort and literature review. Gynecol Oncol 2017; 145: 88.
20. Matsui H, Sekiya S, Hando T et al. Hydatidiform mole coexistent with a twin live fetus: a national collaborative study in Japan. Hum Reprod 2000; 15: 608.
21. Tidy JA, Gillespie AM, Bright N et al. Gestational trophoblastic disease: a study of mode of evacuation and subsequent need for treatment with chemotherapy. Gynecol Oncol 2000; 78: 309.
22. Tse KY, Chan KK, Tam KF, Ngan HY. 20-year experience of managing profuse bleeding in gestational trophoblastic disease. J Reprod Med 2007; 52: 397.
23. Elias KM, Shoni M, Bernstein M et al. Complete hydatidiform mole in women aged 40 to 49 years. J Reprod Med 2012; 57: 254.
24. Elias KM, Goldstein DP, Berkowitz RS. Complete hydatidiform mole in women older than age 50. J Reprod Med 2010; 55: 208.
25. Fu J, Fang F, Xie L et al. Prophylactic chemotherapy for hydatidiform mole to prevent gestational trophoblastic neoplasia. Cochrane Database Syst Rev 2012; 10: CD007289.
26. Limpongsanurak S. Prophylactic actinomycin D for high-risk complete hydatidiform mole. J Reprod Med 2001; 46: 110.
27. FIGO Committee on Gynecologic Oncology. Current FIGO staging for cancer of the vagina, fallopian tube, ovary, and gestational trophoblastic neoplasia. Int J Gynaecol Obstet 2009; 105: 3.
28. Adewole IF, Oladokun A, Fawole AO et al. Fertility regulatory methods and development of complications after evacuation of complete hydatidiform mole. J Obstet Gynaecol 2000; 20: 68.
29. Feltmate CM, Growdon WB, Wolfberg AJ et al. Clinical characteristics of persistent gestational trophoblastic neoplasia after partial hydatidiform molar pregnancy. J Reprod Med 2006; 51: 902.
30. Vargas R, Barroilhet LM, Esselen K et al. Subsequent pregnancy outcomes after complete and partial molar pregnancy, recurrent molar pregnancy, and gestational trophoblastic neoplasia: an update from the New England Trophoblastic Disease Center. J Reprod Med 2014; 59: 188.
31. Sebire NJ, Fisher RA, Foskett M et al. Risk of recurrent hydatidiform mole and subsequent pregnancy outcome following complete or partial hydatidiform molar pregnancy. BJOG 2003; 110:
________________________________________________
2. Altieri A, Franceschi S, Ferlay J et al. Epidemiology and aetiology of gestational trophoblastic diseases. Lancet Oncol 2003; 4: 670.
3. Azuma C, Saji F, Tokugawa Y et al. Application of gene amplification by polymerase chain reaction to genetic analysis of molar mitochondrial DNA: the detection of anuclear empty ovum as the cause of complete mole. Gynecol Oncol 1991; 40: 29.
4. Szulman AE, Surti U. The syndromes of hydatidiform mole. I. Cytogenetic and morphologic correlations. Am J Obstet Gynecol 1978; 131: 665.
5. Melamed A, Gockley AA, Joseph NT et al. Effect of race/ethnicity on risk of complete and partial molar pregnancy after adjustment for age. Gynecol Oncol 2016; 143: 73.
6. Vargas R, Barroilhet LM, Esselen K et al. Subsequent pregnancy outcomes after complete and partial molar pregnancy, recurrent molar pregnancy, and gestational trophoblastic neoplasia: an update from the New England Trophoblastic Disease Center. J Reprod Med 2014; 59: 188.
7. Hershman JM. Physiological and pathological aspects of the effect of human chorionic gonadotropin on the thyroid. Best Pract Res Clin Endocrinol Metab 2004; 18: 249.
8. Braga A, Moraes V, Maestá I et al. Changing Trends in the Clinical Presentation and Management of Complete Hydatidiform Mole Among Brazilian Women. Int J Gynecol Cancer 2016; 26: 984.
9. Committee on Practice Bulletins-Gynecology, American College of Obstetricians and Gynecologists. ACOG Practice Bulletin #53. Diagnosis and treatment of gestational trophoblastic disease. Obstet Gynecol 2004; 103: 1365.
10. Benson CB, Genest DR, Bernstein MR et al. Sonographic appearance of first trimester complete hydatidiform moles. Ultrasound Obstet Gynecol 2000; 16: 188.
11. Fowler DJ, Lindsay I, Seckl MJ, Sebire NJ. Routine pre-evacuation ultrasound diagnosis of hydatidiform mole: experience of more than 1000 cases from a regional referral center. Ultrasound Obstet Gynecol 2006; 27: 56.
12. Seckin KD, Baser E, Yeral I et al. The impact of ultrasonographic lesion size and initial human chorionic gonadotropin values on treatment success in cases with complete hydatidiform mole. Eur Rev Med Pharmacol Sci 2013; 17: 3381.
13. Niemann I, Hansen ES, Sunde L. The risk of persistent trophoblastic disease after hydatidiform mole classified by morphology and ploidy. Gynecol Oncol 2007; 104: 411.
14. Shazly SA, Ali MK, Abdel Badee AY et al. Twin pregnancy with complete hydatidiform mole and coexisting fetus following ovulation induction with a non-prescribed clomiphene citrate regimen: a case report. J Med Case Rep 2012; 6: 95.
15. Hancock BW, Nazir K, Everard JE. Persistent gestational trophoblastic neoplasia after partial hydatidiform mole incidence and outcome. J Reprod Med 2006; 51: 764.
16. Massardier J, Golfier F, Journet D et al. Twin pregnancy with complete hydatidiform mole and coexistent fetus: obstetrical and oncological outcomes in a series of 14 cases. Eur J Obstet Gynecol Reprod Biol 2009; 143: 84.
17. Niemann L, Fisher R, Sebire NJ et al. Update on UK outcomes for women with twin pregnancies comprising a complete hydatidiform mole and normal co-twin. XVII World Congress on Gestational Trophoblastic Disease. 2013; p. 57 (abstract).
18. Steller MA, Genest DR, Bernstein MR et al. Clinical features of multiple conception with partial or complete molar pregnancy and coexisting fetuses. J Reprod Med 1994; 39: 147.
19. Lin LH, Maestá I, Braga A et al. Multiple pregnancies with complete mole and coexisting normal fetus in North and South America: A retrospective multicenter cohort and literature review. Gynecol Oncol 2017; 145: 88.
20. Matsui H, Sekiya S, Hando T et al. Hydatidiform mole coexistent with a twin live fetus: a national collaborative study in Japan. Hum Reprod 2000; 15: 608.
21. Tidy JA, Gillespie AM, Bright N et al. Gestational trophoblastic disease: a study of mode of evacuation and subsequent need for treatment with chemotherapy. Gynecol Oncol 2000; 78: 309.
22. Tse KY, Chan KK, Tam KF, Ngan HY. 20-year experience of managing profuse bleeding in gestational trophoblastic disease. J Reprod Med 2007; 52: 397.
23. Elias KM, Shoni M, Bernstein M et al. Complete hydatidiform mole in women aged 40 to 49 years. J Reprod Med 2012; 57: 254.
24. Elias KM, Goldstein DP, Berkowitz RS. Complete hydatidiform mole in women older than age 50. J Reprod Med 2010; 55: 208.
25. Fu J, Fang F, Xie L et al. Prophylactic chemotherapy for hydatidiform mole to prevent gestational trophoblastic neoplasia. Cochrane Database Syst Rev 2012; 10: CD007289.
26. Limpongsanurak S. Prophylactic actinomycin D for high-risk complete hydatidiform mole. J Reprod Med 2001; 46: 110.
27. FIGO Committee on Gynecologic Oncology. Current FIGO staging for cancer of the vagina, fallopian tube, ovary, and gestational trophoblastic neoplasia. Int J Gynaecol Obstet 2009; 105: 3.
28. Adewole IF, Oladokun A, Fawole AO et al. Fertility regulatory methods and development of complications after evacuation of complete hydatidiform mole. J Obstet Gynaecol 2000; 20: 68.
29. Feltmate CM, Growdon WB, Wolfberg AJ et al. Clinical characteristics of persistent gestational trophoblastic neoplasia after partial hydatidiform molar pregnancy. J Reprod Med 2006; 51: 902.
30. Vargas R, Barroilhet LM, Esselen K et al. Subsequent pregnancy outcomes after complete and partial molar pregnancy, recurrent molar pregnancy, and gestational trophoblastic neoplasia: an update from the New England Trophoblastic Disease Center. J Reprod Med 2014; 59: 188.
31. Sebire NJ, Fisher RA, Foskett M et al. Risk of recurrent hydatidiform mole and subsequent pregnancy outcome following complete or partial hydatidiform molar pregnancy. BJOG 2003; 110:
Авторы
Ю.Э. Доброхотова1, С.Э. Аракелов2, С.Ж. Данелян2, Е.И. Боровкова*1, С.А. Залесская1, М.К. Меджидова2, Е.А. Нагайцева2
1. ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, Москва, Россия;
2. ГБУЗ «Городская клиническая больница №40» Департамента здравоохранения г. Москвы, Москва, Россия
*katyanikitina@mail.ru
1. Pirogov Russian National Research Medical University, Moscow, Russia;
2. City Clinical Hospital №40, Moscow, Russia
*katyanikitina@mail.ru
1. ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, Москва, Россия;
2. ГБУЗ «Городская клиническая больница №40» Департамента здравоохранения г. Москвы, Москва, Россия
*katyanikitina@mail.ru
________________________________________________
1. Pirogov Russian National Research Medical University, Moscow, Russia;
2. City Clinical Hospital №40, Moscow, Russia
*katyanikitina@mail.ru
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