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Роль генетических полиморфизмов генов VEGF, COX2, MUC в развитии эндометриозассоциированного бесплодия
Роль генетических полиморфизмов генов VEGF, COX2, MUC в развитии эндометриозассоциированного бесплодия
Куликова Н.В., Коваленко И.И., Байбуз Д.В., Лебедева Я.А. Роль генетических полиморфизмов генов VEGF, COX2, MUC в развитии эндометриоз-ассоциированного бесплодия. Гинекология. 2019; 21 (2): 34–37.
DOI: 10.26442/20795696.2019.2.190344
DOI: 10.26442/20795696.2019.2.190344
DOI: 10.26442/20795696.2019.2.190344
________________________________________________
DOI: 10.26442/20795696.2019.2.190344
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Аннотация
Эндометриозассоциированное бесплодие представляет собой важную медико-социальную проблему, так как поражает до 10% женщин репродуктивного возраста, при этом даже после длительной терапии беременность наступает лишь у 1/3 пациенток. Этиология эндометриоза до сих пор точно не определена, несмотря на постоянные научные исследования в этой области, поэтому в данном обзоре литературы мы постарались осветить основные работы, затрагивающие роль иммунологических и генетических факторов в патогенезе эндометриоза. Наиболее детально рассмотрено участие сосудистого эндотелиального фактора роста, муцинов и циклооксигеназы-2 в развитии данного заболевания. Дальнейшие исследования этих патогенетических механизмов бесплодия у пациенток с эндометриозом позволят своевременно их корректировать, тем самым увеличивая шансы наступления беременности.
Ключевые слова: эндометриозассоциированное бесплодие, муцины, сосудистый эндотелиальный фактор роста, циклооксигеназа-2, невынашивание беременности, репродуктивные потери.
Key words: endometriosis-associated infertility, mucins, vascular endothelial growth factor, cyclooxygenase-2, miscarriage, pregnancy, reproductive loss.
Ключевые слова: эндометриозассоциированное бесплодие, муцины, сосудистый эндотелиальный фактор роста, циклооксигеназа-2, невынашивание беременности, репродуктивные потери.
________________________________________________
Key words: endometriosis-associated infertility, mucins, vascular endothelial growth factor, cyclooxygenase-2, miscarriage, pregnancy, reproductive loss.
Полный текст
Список литературы
1. Абу-Абдаллах М., Артымук Н.В., Сурина М.Н. Рецептивность эндометрия. Маркеры имплантации. Фундаментальная и клиническая медицина. 2018; 3: 71–7.
[Abu-Abdallakh M., Artymuk N.V., Surina M.N. Retseptivnost' endometriia. Markery implantatsii. Fundamental'naia i klinicheskaia meditsina. 2018; 3: 71–7 (in Russian).]
2. Агаркова Т.А. Полиморфизм гена TGFВ при эндометриоз-ассоциированном бесплодии. Фундаментальные исследования. 2013; 3: 241–4.
[Agarkova T.A. Polimorfizm gena TGFV pri endometrioz-assotsiirovannom besplodii. Fundamental'nye issledovaniia. 2013; 3: 241–4 (in Russian).]
3. Ведищев С.И., Прокопов А.Ю., Османов Э.М. Клинико-эпидемиологические аспекты женского бесплодия в браке. Евразийский союз ученых. 2015; 7 (16): 33–4.
[Vedishchev S.I., Prokopov A.Iu., Osmanov E.M. Kliniko-epidemiologicheskie aspekty zhenskogo besplodiia v brake. Evraziiskii soiuz uchenykh. 2015; 7 (16): 33–4 (in Russian).]
4. Гончарова Н.Н., Мартышкина Е.Ю., Казначеева Т.В. Медико-генетические аспекты бесплодия. Акушерство, гинекология и репродукция. 2012; 6 (2): 35–40.
[Goncharova N.N., Martyshkina E.Iu., Kaznacheeva T.V. Mediko-geneticheskie aspekty besplodiia. Akusherstvo, ginekologiia i reproduktsiia. 2012; 6 (2): 35–40 (in Russian).]
5. Долбина А.Ю. Полиморфизм генетических маркеров, особенности течения беременности и исход родов после лечения женского бесплодия. Автореф. дис. … канд. мед. наук. Иркутск, 2007.
[Dolbina A.Iu. Polimorfizm geneticheskikh markerov, osobennosti techeniia beremennosti i iskhod rodov posle lecheniia zhenskogo besplodiia. Avtoref. dis. … kand. med. nauk. Irkutsk, 2007 (in Russian).]
6. Козырева Е.В., Давидян Л.Ю. Роль факторов роста в патогенезе бесплодия и невынашивания беременности. Современные проблемы науки и образования. 2015; 4: 12.
[Kozyreva E.V., Davidian L.Iu. Rol' faktorov rosta v patogeneze besplodiia i nevynashivaniia beremennosti. Sovremennye problemy nauki i obrazovaniia. 2015; 4: 12 (in Russian).]
7. Корсак В.С., Васильева О.Е., Исакова Э.В. Эндометриоз и ВРТ. Проблемы репродукции. 2006; 3: 41–6.
[Korsak V.S., Vasil'eva O.E., Isakova E.V. Endometrioz i VRT. Problemy reproduktsii. 2006; 3: 41–6 (in Russian).]
8. Овсянникова Т.В., Куликов И.А. Бесплодный брак: алгоритмы диагностики и лечения. Эффективная фармакотерапия. 2016; 22: 24–7.
[Ovsiannikova T.V., Kulikov I.A. Besplodnyi brak: algoritmy diagnostiki i lecheniia. Effektivnaia farmakoterapiia. 2016; 22: 24–7 (in Russian).]
9. Смирнова И.В., Бресский А.Г., Лысенко О.В. Эндометриоз-ассоциированное бесплодие. Охрана материнства и детства. 2011; 1 (17): 63.
[Smirnova I.V., Bresskii A.G., Lysenko O.V. Endometrioz-assotsiirovannoe besplodie. Okhrana materinstva i detstva. 2011; 1 (17): 63 (in Russian).]
10. Ходжаева З.С., Мусиенко Е.В. Клинико-патогенетическое обоснование исследования секреции ангиогенных факторов в лютеиновую фазу менструального цикла у женщин с повторными потерями беременности в анамнезе. Акушерство и гинекология. 2011; 8.
[Khodzhaeva Z.S., Musienko E.V. Kliniko-patogeneticheskoe obosnovanie issledovaniia sekretsii angiogennykh faktorov v liuteinovuiu fazu menstrual'nogo tsikla u zhenshchin s povtornymi poteriami beremennosti v anamneze. Akusherstvo i ginekologiia. 2011; 8 (in Russian).]
11. Acimovic M et al. Survivin and VEGF as Novel Biomarkers in Diagnosis of Endometriosis M. Acimovic. J Med Biochem 2016; 35 (1): 63–8.
12. Baranov VS et al. Systems genetics view of endometriosis: a common complex disorder. Eur J Obstet Gynecol Reprod Biol 2015; 185: 9–65.
13. Bilotas M et al. Effect of vascular endothelial growth factor and interleukin-1beta on apoptosis in endometrial cell cultures from patients with endometriosis and controls. J Reprod Immunol 2010; 84 (2): 193–8.
14. Chang CY et al. MUC4 gene polymorphisms associate with endometriosis development and endometriosis – related infertility. BMC Medicine 2011; 9: 19.
15. Dai H et al. Expression of Efp, VEGF and bFGF in normal, hyperplastic and malignant endometrial tissue. Oncol Rep 2010; 23 (3): 795–9.
16. Ferrara N. VEGF and the quest for tumour angiogenesis factors. Nat Rev Cancer 2002; 2 (10): 795–803.
17. Grummer R et al. Different regulatory pathways of endometrial connexin expression: preimplantation hormonal-mediated pathway versus embyo implantation-initiated pathway. Biol Reprod 2004; 71 (1): 273–81.
18. Heng S et al. PC6 levels in uterine lavage are closely associated with uterine receptivity and significantly lower in a subgroup of women with unexplained infertility. Hum Reprod 2011; 26 (4): 840–6.
19. Jana S et al. Regulation of Matrix Metalloproteinase-2 Activity by COX-2-PGE2-pAKT Axis Promotes Angiogenesis in Endometriosis. PLoS One 2016; 11 (10): e0163540.
20. Krieg SA et al. Global alteration in gene expression profiles of deciduas from women with idiopathic recurrent pregnancy loss. Mol Hum Reprod 2012; 18 (9): 442–50.
21. Laanpere M et al. Folate-metabolizing gene variants and pregnancy outcome of IVF. Reprod Biomed Online 2011; 22 (6): 603–14.
22. Matalliotakis IM et al. Serum concentrations of growth factors in women with and without endometriosis: the action of anti-endometriosis medicines. Int Immunopharmacol 2003; 3: 81–9.
23. McLaren J. Vascular endothelial growth factor and endometriotic angiogenesis. Hum Reprod Update 2000; 6 (1): 45–55.
24. Meseguer M et al. Human endometrialmucin MUC1 is up-regulated by progesterone and down-regulated in vitro by the human blastocyst. Biol Reprod 2001; 64: 590–601.
25. Mourik MS, Macklon NS, Heijnen CJ. Embryonic implantation: cytokines, adhesion molecules and immune cells in establishing an implantation environment. Lekoc Biol 2009; 85: 4–19.
26. Olsson AK et al. VEGF receptor signaling – in control of vascular function. Nat Rev Mol Cell Biol 2006; 7 (5): 359–71.
27. Pellicer A et al. The follicular and endocrine environment in women with endometriosis: local and systemic cytokine production. Fertil Steril 1998; 70: 425–31.
28. Puschett JB, Agunanne E, Uddin MN. Marinobufagenin, resibufogenin and preeclampsia. Biochim Biophys Acta 2010; 1802 (12): 1246–53.
29. Robati M et al. Vascular endothelial growth factor (VEGF) improves the sensitivity of CA125 for differentiation of epithelial ovarian cancers from ovarian cysts. Arch Gynecol Obstet 2013; 288 (4): 859–65.
30. Sater MS et al. Anti-annexin V IgM and IgG autoantibodies and the risk of idiopathic recurrent spontaneous miscarriage. J Reprod Immunol 2011; 89 (1): 78–83.
31. Shaw JL et al. Lymphoid and myeloid cell populations in the non-pregnant human Fallopian tube and in ectopic pregnancy. J Reprod Immunol 2011; 89 (1): 84–91.
32. Urato AC, Norwitz ER. A guide towards pre-pregnancy management of defective implantation and placentation. Best Pract Res Clin Obstet Gynaecol 2011; 25 (3): 367–87.
33. Yang XJ Telocytes damage in endometriosis-affected rat oviduct and potential impact on fertility. J Cell Mol Med 2015; 19 (2): 452–62.
2. Agarkova T.A. Polimorfizm gena TGFV pri endometrioz-assotsiirovannom besplodii. Fundamental'nye issledovaniia. 2013; 3: 241–4 (in Russian).
3. Vedishchev S.I., Prokopov A.Iu., Osmanov E.M. Kliniko-epidemiologicheskie aspekty zhenskogo besplodiia v brake. Evraziiskii soiuz uchenykh. 2015; 7 (16): 33–4 (in Russian).
4. Goncharova N.N., Martyshkina E.Iu., Kaznacheeva T.V. Mediko-geneticheskie aspekty besplodiia. Akusherstvo, ginekologiia i reproduktsiia. 2012; 6 (2): 35–40 (in Russian).
5. Dolbina A.Iu. Polimorfizm geneticheskikh markerov, osobennosti techeniia beremennosti i iskhod rodov posle lecheniia zhenskogo besplodiia. Avtoref. dis. … kand. med. nauk. Irkutsk, 2007 (in Russian).
6. Kozyreva E.V., Davidian L.Iu. Rol' faktorov rosta v patogeneze besplodiia i nevynashivaniia beremennosti. Sovremennye problemy nauki i obrazovaniia. 2015; 4: 12 (in Russian).
7. Korsak V.S., Vasil'eva O.E., Isakova E.V. Endometrioz i VRT. Problemy reproduktsii. 2006; 3: 41–6 (in Russian).
8. Ovsiannikova T.V., Kulikov I.A. Besplodnyi brak: algoritmy diagnostiki i lecheniia. Effektivnaia farmakoterapiia. 2016; 22: 24–7 (in Russian).
9. Smirnova I.V., Bresskii A.G., Lysenko O.V. Endometrioz-assotsiirovannoe besplodie. Okhrana materinstva i detstva. 2011; 1 (17): 63 (in Russian).
10. Khodzhaeva Z.S., Musienko E.V. Kliniko-patogeneticheskoe obosnovanie issledovaniia sekretsii angiogennykh faktorov v liuteinovuiu fazu menstrual'nogo tsikla u zhenshchin s povtornymi poteriami beremennosti v anamneze. Akusherstvo i ginekologiia. 2011; 8 (in Russian).
11. Acimovic M et al. Survivin and VEGF as Novel Biomarkers in Diagnosis of Endometriosis M. Acimovic. J Med Biochem 2016; 35 (1): 63–8.
12. Baranov VS et al. Systems genetics view of endometriosis: a common complex disorder. Eur J Obstet Gynecol Reprod Biol 2015; 185: 9–65.
13. Bilotas M et al. Effect of vascular endothelial growth factor and interleukin-1beta on apoptosis in endometrial cell cultures from patients with endometriosis and controls. J Reprod Immunol 2010; 84 (2): 193–8.
14. Chang CY et al. MUC4 gene polymorphisms associate with endometriosis development and endometriosis – related infertility. BMC Medicine 2011; 9: 19.
15. Dai H et al. Expression of Efp, VEGF and bFGF in normal, hyperplastic and malignant endometrial tissue. Oncol Rep 2010; 23 (3): 795–9.
16. Ferrara N. VEGF and the quest for tumour angiogenesis factors. Nat Rev Cancer 2002; 2 (10): 795–803.
17. Grummer R et al. Different regulatory pathways of endometrial connexin expression: preimplantation hormonal-mediated pathway versus embyo implantation-initiated pathway. Biol Reprod 2004; 71 (1): 273–81.
18. Heng S et al. PC6 levels in uterine lavage are closely associated with uterine receptivity and significantly lower in a subgroup of women with unexplained infertility. Hum Reprod 2011; 26 (4): 840–6.
19. Jana S et al. Regulation of Matrix Metalloproteinase-2 Activity by COX-2-PGE2-pAKT Axis Promotes Angiogenesis in Endometriosis. PLoS One 2016; 11 (10): e0163540.
20. Krieg SA et al. Global alteration in gene expression profiles of deciduas from women with idiopathic recurrent pregnancy loss. Mol Hum Reprod 2012; 18 (9): 442–50.
21. Laanpere M et al. Folate-metabolizing gene variants and pregnancy outcome of IVF. Reprod Biomed Online 2011; 22 (6): 603–14.
22. Matalliotakis IM et al. Serum concentrations of growth factors in women with and without endometriosis: the action of anti-endometriosis medicines. Int Immunopharmacol 2003; 3: 81–9.
23. McLaren J. Vascular endothelial growth factor and endometriotic angiogenesis. Hum Reprod Update 2000; 6 (1): 45–55.
24. Meseguer M et al. Human endometrialmucin MUC1 is up-regulated by progesterone and down-regulated in vitro by the human blastocyst. Biol Reprod 2001; 64: 590–601.
25. Mourik MS, Macklon NS, Heijnen CJ. Embryonic implantation: cytokines, adhesion molecules and immune cells in establishing an implantation environment. Lekoc Biol 2009; 85: 4–19.
26. Olsson AK et al. VEGF receptor signaling – in control of vascular function. Nat Rev Mol Cell Biol 2006; 7 (5): 359–71.
27. Pellicer A et al. The follicular and endocrine environment in women with endometriosis: local and systemic cytokine production. Fertil Steril 1998; 70: 425–31.
28. Puschett JB, Agunanne E, Uddin MN. Marinobufagenin, resibufogenin and preeclampsia. Biochim Biophys Acta 2010; 1802 (12): 1246–53.
29. Robati M et al. Vascular endothelial growth factor (VEGF) improves the sensitivity of CA125 for differentiation of epithelial ovarian cancers from ovarian cysts. Arch Gynecol Obstet 2013; 288 (4): 859–65.
30. Sater MS et al. Anti-annexin V IgM and IgG autoantibodies and the risk of idiopathic recurrent spontaneous miscarriage. J Reprod Immunol 2011; 89 (1): 78–83.
31. Shaw JL et al. Lymphoid and myeloid cell populations in the non-pregnant human Fallopian tube and in ectopic pregnancy. J Reprod Immunol 2011; 89 (1): 84–91.
32. Urato AC, Norwitz ER. A guide towards pre-pregnancy management of defective implantation and placentation. Best Pract Res Clin Obstet Gynaecol 2011; 25 (3): 367–87.
33. Yang XJ Telocytes damage in endometriosis-affected rat oviduct and potential impact on fertility. J Cell Mol Med 2015; 19 (2): 452–62.
[Abu-Abdallakh M., Artymuk N.V., Surina M.N. Retseptivnost' endometriia. Markery implantatsii. Fundamental'naia i klinicheskaia meditsina. 2018; 3: 71–7 (in Russian).]
2. Агаркова Т.А. Полиморфизм гена TGFВ при эндометриоз-ассоциированном бесплодии. Фундаментальные исследования. 2013; 3: 241–4.
[Agarkova T.A. Polimorfizm gena TGFV pri endometrioz-assotsiirovannom besplodii. Fundamental'nye issledovaniia. 2013; 3: 241–4 (in Russian).]
3. Ведищев С.И., Прокопов А.Ю., Османов Э.М. Клинико-эпидемиологические аспекты женского бесплодия в браке. Евразийский союз ученых. 2015; 7 (16): 33–4.
[Vedishchev S.I., Prokopov A.Iu., Osmanov E.M. Kliniko-epidemiologicheskie aspekty zhenskogo besplodiia v brake. Evraziiskii soiuz uchenykh. 2015; 7 (16): 33–4 (in Russian).]
4. Гончарова Н.Н., Мартышкина Е.Ю., Казначеева Т.В. Медико-генетические аспекты бесплодия. Акушерство, гинекология и репродукция. 2012; 6 (2): 35–40.
[Goncharova N.N., Martyshkina E.Iu., Kaznacheeva T.V. Mediko-geneticheskie aspekty besplodiia. Akusherstvo, ginekologiia i reproduktsiia. 2012; 6 (2): 35–40 (in Russian).]
5. Долбина А.Ю. Полиморфизм генетических маркеров, особенности течения беременности и исход родов после лечения женского бесплодия. Автореф. дис. … канд. мед. наук. Иркутск, 2007.
[Dolbina A.Iu. Polimorfizm geneticheskikh markerov, osobennosti techeniia beremennosti i iskhod rodov posle lecheniia zhenskogo besplodiia. Avtoref. dis. … kand. med. nauk. Irkutsk, 2007 (in Russian).]
6. Козырева Е.В., Давидян Л.Ю. Роль факторов роста в патогенезе бесплодия и невынашивания беременности. Современные проблемы науки и образования. 2015; 4: 12.
[Kozyreva E.V., Davidian L.Iu. Rol' faktorov rosta v patogeneze besplodiia i nevynashivaniia beremennosti. Sovremennye problemy nauki i obrazovaniia. 2015; 4: 12 (in Russian).]
7. Корсак В.С., Васильева О.Е., Исакова Э.В. Эндометриоз и ВРТ. Проблемы репродукции. 2006; 3: 41–6.
[Korsak V.S., Vasil'eva O.E., Isakova E.V. Endometrioz i VRT. Problemy reproduktsii. 2006; 3: 41–6 (in Russian).]
8. Овсянникова Т.В., Куликов И.А. Бесплодный брак: алгоритмы диагностики и лечения. Эффективная фармакотерапия. 2016; 22: 24–7.
[Ovsiannikova T.V., Kulikov I.A. Besplodnyi brak: algoritmy diagnostiki i lecheniia. Effektivnaia farmakoterapiia. 2016; 22: 24–7 (in Russian).]
9. Смирнова И.В., Бресский А.Г., Лысенко О.В. Эндометриоз-ассоциированное бесплодие. Охрана материнства и детства. 2011; 1 (17): 63.
[Smirnova I.V., Bresskii A.G., Lysenko O.V. Endometrioz-assotsiirovannoe besplodie. Okhrana materinstva i detstva. 2011; 1 (17): 63 (in Russian).]
10. Ходжаева З.С., Мусиенко Е.В. Клинико-патогенетическое обоснование исследования секреции ангиогенных факторов в лютеиновую фазу менструального цикла у женщин с повторными потерями беременности в анамнезе. Акушерство и гинекология. 2011; 8.
[Khodzhaeva Z.S., Musienko E.V. Kliniko-patogeneticheskoe obosnovanie issledovaniia sekretsii angiogennykh faktorov v liuteinovuiu fazu menstrual'nogo tsikla u zhenshchin s povtornymi poteriami beremennosti v anamneze. Akusherstvo i ginekologiia. 2011; 8 (in Russian).]
11. Acimovic M et al. Survivin and VEGF as Novel Biomarkers in Diagnosis of Endometriosis M. Acimovic. J Med Biochem 2016; 35 (1): 63–8.
12. Baranov VS et al. Systems genetics view of endometriosis: a common complex disorder. Eur J Obstet Gynecol Reprod Biol 2015; 185: 9–65.
13. Bilotas M et al. Effect of vascular endothelial growth factor and interleukin-1beta on apoptosis in endometrial cell cultures from patients with endometriosis and controls. J Reprod Immunol 2010; 84 (2): 193–8.
14. Chang CY et al. MUC4 gene polymorphisms associate with endometriosis development and endometriosis – related infertility. BMC Medicine 2011; 9: 19.
15. Dai H et al. Expression of Efp, VEGF and bFGF in normal, hyperplastic and malignant endometrial tissue. Oncol Rep 2010; 23 (3): 795–9.
16. Ferrara N. VEGF and the quest for tumour angiogenesis factors. Nat Rev Cancer 2002; 2 (10): 795–803.
17. Grummer R et al. Different regulatory pathways of endometrial connexin expression: preimplantation hormonal-mediated pathway versus embyo implantation-initiated pathway. Biol Reprod 2004; 71 (1): 273–81.
18. Heng S et al. PC6 levels in uterine lavage are closely associated with uterine receptivity and significantly lower in a subgroup of women with unexplained infertility. Hum Reprod 2011; 26 (4): 840–6.
19. Jana S et al. Regulation of Matrix Metalloproteinase-2 Activity by COX-2-PGE2-pAKT Axis Promotes Angiogenesis in Endometriosis. PLoS One 2016; 11 (10): e0163540.
20. Krieg SA et al. Global alteration in gene expression profiles of deciduas from women with idiopathic recurrent pregnancy loss. Mol Hum Reprod 2012; 18 (9): 442–50.
21. Laanpere M et al. Folate-metabolizing gene variants and pregnancy outcome of IVF. Reprod Biomed Online 2011; 22 (6): 603–14.
22. Matalliotakis IM et al. Serum concentrations of growth factors in women with and without endometriosis: the action of anti-endometriosis medicines. Int Immunopharmacol 2003; 3: 81–9.
23. McLaren J. Vascular endothelial growth factor and endometriotic angiogenesis. Hum Reprod Update 2000; 6 (1): 45–55.
24. Meseguer M et al. Human endometrialmucin MUC1 is up-regulated by progesterone and down-regulated in vitro by the human blastocyst. Biol Reprod 2001; 64: 590–601.
25. Mourik MS, Macklon NS, Heijnen CJ. Embryonic implantation: cytokines, adhesion molecules and immune cells in establishing an implantation environment. Lekoc Biol 2009; 85: 4–19.
26. Olsson AK et al. VEGF receptor signaling – in control of vascular function. Nat Rev Mol Cell Biol 2006; 7 (5): 359–71.
27. Pellicer A et al. The follicular and endocrine environment in women with endometriosis: local and systemic cytokine production. Fertil Steril 1998; 70: 425–31.
28. Puschett JB, Agunanne E, Uddin MN. Marinobufagenin, resibufogenin and preeclampsia. Biochim Biophys Acta 2010; 1802 (12): 1246–53.
29. Robati M et al. Vascular endothelial growth factor (VEGF) improves the sensitivity of CA125 for differentiation of epithelial ovarian cancers from ovarian cysts. Arch Gynecol Obstet 2013; 288 (4): 859–65.
30. Sater MS et al. Anti-annexin V IgM and IgG autoantibodies and the risk of idiopathic recurrent spontaneous miscarriage. J Reprod Immunol 2011; 89 (1): 78–83.
31. Shaw JL et al. Lymphoid and myeloid cell populations in the non-pregnant human Fallopian tube and in ectopic pregnancy. J Reprod Immunol 2011; 89 (1): 84–91.
32. Urato AC, Norwitz ER. A guide towards pre-pregnancy management of defective implantation and placentation. Best Pract Res Clin Obstet Gynaecol 2011; 25 (3): 367–87.
33. Yang XJ Telocytes damage in endometriosis-affected rat oviduct and potential impact on fertility. J Cell Mol Med 2015; 19 (2): 452–62.
________________________________________________
2. Agarkova T.A. Polimorfizm gena TGFV pri endometrioz-assotsiirovannom besplodii. Fundamental'nye issledovaniia. 2013; 3: 241–4 (in Russian).
3. Vedishchev S.I., Prokopov A.Iu., Osmanov E.M. Kliniko-epidemiologicheskie aspekty zhenskogo besplodiia v brake. Evraziiskii soiuz uchenykh. 2015; 7 (16): 33–4 (in Russian).
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Авторы
Н.В. Куликова*1,2, И.И. Коваленко2, Д.В. Байбуз2, Я.А. Лебедева2
1. ФГАОУ ВО «Балтийский федеральный университет им. Иммануила Канта», Калининград, Россия;
2. ФГБОУ ВО «Санкт-Петербургский государственный университет», Санкт-Петербург, Россия
*dockulikova@rambler.ru
1. Immanuel Kant Baltic Federal University, Kaliningrad, Russia;
2 .Saint Petersburg State University, Saint Petersburg, Russia
*dockulikova@rambler.ru
1. ФГАОУ ВО «Балтийский федеральный университет им. Иммануила Канта», Калининград, Россия;
2. ФГБОУ ВО «Санкт-Петербургский государственный университет», Санкт-Петербург, Россия
*dockulikova@rambler.ru
________________________________________________
1. Immanuel Kant Baltic Federal University, Kaliningrad, Russia;
2 .Saint Petersburg State University, Saint Petersburg, Russia
*dockulikova@rambler.ru
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