Вакцинация как эффективный метод профилактики заболеваний шейки матки, ассоциированных с вирусом папилломы человека (обзор литературы)

Прилепская В.Н., Гусаков К.И., Назарова Н.М. Вакцинация как эффективный метод профилактики заболеваний шейки матки, ассоциированных с вирусом папилломы человека (обзор литературы). Гинекология. 2019; 21 (2): 23–27. DOI: 10.26442/20795696.2019.2.190396

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Prilepskaya V.N., Gusakov K.I., Nazarova N.M. Vaccination as an effective method of prevention for cervical diseases associated with human papillomavirus (literature review). Gynecology. 2019; 21 (2): 23–27. DOI: 10.26442/20795696.2019.2.190396

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Аннотация

Роль вируса папилломы человека (ВПЧ) в развитии рака шейки матки (РШМ) и других заболеваний аногенитальной области доказана и общеизвестна. Несмотря на это, ежегодно отмечается рост показателей заболеваемости РШМ. Специфические методы противовирусного лечения ВПЧ не разработаны, а единственным действенным способом предотвращения РШМ и других ВПЧ-ассоциированных заболеваний является профилактика инфицирования. В целом ряде рандомизированных клинических исследований продемонстрирована чрезвычайно высокая (до 100%) эффективность вакцин от ВПЧ. В настоящее время вакцина от ВПЧ одобрена Всемирной организацией здравоохранения и включена в национальные программы иммунизации 86 государств, а в 17 странах применяется гендерно-нейтральная программа, предусматривающая вакцинацию девочек и мальчиков. В клинической практике Австралии, США и странах Европейского союза, в частности в Италии, Германии, Франции, где вакцинация от ВПЧ включена в национальную программу вакцинации, отмечается высокая эффективность вакцинации в течение 10 и более лет после нее.

Ключевые слова: вакцинация, вирус папилломы человека, рак шейки матки.

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The role of human papillomavirus (HPV) in the development of cervical cancer and other diseases of the anogenital area has been proven and well known. Despite this, the incidence of cervical cancer is growing every year. Specific methods of HPV treatment are not developed, and the only effective method of cervical cancer prevention is to prevent infection itself. A number of randomized clinical trials have demonstrated extremely high (up to 100%) effectiveness of HPV vaccines. Currently, the HPV vaccine is approved by WHO and included in the National Immunization Program of 86 countries, 17 counties use gender-neutral program. In the clinical practice of Australia, USA and countries of the European Union, in particular Italy, Germany and France, high efficiency of vaccination for 10 or more years is reported.

Key words: vaccination, human papillomavirus, cervical cancer.

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Список литературы

1. Грецова О.П., Костин А.А. и др. Заболеваемость и смертность от злокачественных новообразований, ассоциированных с вирусом папилломы человека. Исследования и практика в медицине. 2017; 4 (3).
[Gretsova O.P., Kostin A.A. et al. Zabolevaemost' i smertnost' ot zlokachestvennykh novoobrazovanii, assotsiirovannykh s virusom papillomy cheloveka. Issledovaniia i praktika v meditsine. 2017; 4 (3) (in Russian).]
2. Bruni L et al. ICO Information Centre on HPV and Cancer (HPV Information Centre). Human Papillomavirus and Related Diseases in Russian Federation. Summary Report 7 October 2016. http://www.hpvcentre.net/statistics/reports/XWX.pdf.
3. Diego Chouhy et al. Analysis of the genetic diversity and phylogenetic relationships of putative human papillomavirus types. Gen Virol 2015; 94 (11): 2480–8. DOI: 10.1099/vir.0.055137-0
4. Довлетханова Э.Р., Прилепская В.Н. Папилломавирусная инфекция. Теоретические и практические аспекты. ГЭОТАР-Медиа, 2018.
[Dovletkhanova E.R., Prilepskaia V.N. Papillomavirusnaia infektsiia. Teoreticheskie i prakticheskie aspekty. GEOTAR-Media, 2018 (in Russian).]
5. Koutsky L et al. A Cohort Study of the Risk of Cervical Intraepithelial Neoplasia Grade 2 or 3 in Relation to Papillomavirus Infection. N Engl J Med 1992; 327: 1272–8. DOI: 10.1056/NEJM199210293271804
6. FDA approves expanded use of Gardasil 9 to include individuals 27 through 45 years old. https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm622715.htm
7. Garland SM et al. Quadrivalent vaccine against human papillomavirus to prevent anogenital diseases. N Engl J Med 2007; 356 (19): 1928–43.
8. Joura EA, Leodolter S, Hernandez-Avila M et al. Efficacy of a quadrivalent prophylactic human papillomavirus (types 6, 11, 16, and 18) L1 virus-like-particle vaccine against high-grade vulval and vaginal lesions: a combined analysis of three randomised clinical trials. Lancet 2007; 369: 1693–702.
9. Joura EA. Quadrivalent Vaccine against Human Papillomavirus to Prevent High-Grade Cervical Lesions. N Engl J Med 2007; 356: 1915–27.
10. Drolet M et al. Population-level impact and herd effects following human papillomavirus vaccination programmes: a systematic review and meta-analysis. Lancet Infect Dis 2015; 15: 565–80.
11. Joura EA, Garland SM, Paavonen J et al. Effect of the human papillomavirus (HPV) quadrivalent vaccine in a subgroup of women with cervical and vulvar disease: retrospective pooled analysis of trial data. FUTURE I and II study group. BMJ 2012; 344: e1401.
12. Garland SM, Paavonen J, Jaisamrarn U et al. HPV PATRICIA Study Group, Prior human papillomavirus-16/18 AS04-adjuvanted vaccination prevents recurrent high-grade cervicalintraepithelial neoplasia after definitive surgical therapy: post- hoc analysis from a randomized controlled trial. Int J Cancer 2016; 139 (12): 2812–26.
13. Swedish KA, Factor SH, Goldstone SE. Prevention of recurrent high-grade anal neoplasia with quadrivalent human papillomavirus vaccination of men who have sex with men: a nonconcurrent cohort study. Clin Infect Dis 2012; 54 (7): 891–8.
14. Deshmukh A, Cantor SB, Fenwick E et al. Adjuvant HPV vaccination for anal cancer prevention in HIV-positive men who have sex with men: the time is now. Vaccine 2017; 35 (38): 5102–9.
15. Harper DM. HPV vaccines – Review of the first decade. Gyn Onc 2017; 146: 196–204.
16. Joura EA et al. N Engl J Med 2015; 372: 711–23. Suppl. disease. Abstract MSS 2–5 presented at EUROGIN 2015, Seville, Spain.
17. Steben M. Review of the impact and effectiveness of the Quadrivalent Human Papillomavirus Vaccine: 10 Years of Clinical Experience in Canada. J Obstet Gynaecol Can 2018; 40 (12): 1635–45.
18. Esquerre M, Bouillette-Marussig M. GTL001, a bivalent therapeutic vaccine against human papillomavirus 16 and 18, induces antigen-specific CD8+ T-cell responses leading to tumor regression. PLoS One 2017; 12 (3): e0174038.

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1. Gretsova O.P., Kostin A.A. et al. Zabolevaemost' i smertnost' ot zlokachestvennykh novoobrazovanii, assotsiirovannykh s virusom papillomy cheloveka. Issledovaniia i praktika v meditsine. 2017; 4 (3) (in Russian).
2. Bruni L et al. ICO Information Centre on HPV and Cancer (HPV Information Centre). Human Papillomavirus and Related Diseases in Russian Federation. Summary Report 7 October 2016. http://www.hpvcentre.net/statistics/reports/XWX.pdf.
3. Diego Chouhy et al. Analysis of the genetic diversity and phylogenetic relationships of putative human papillomavirus types. Gen Virol 2015; 94 (11): 2480–8. DOI: 10.1099/vir.0.055137-0
4. Dovletkhanova E.R., Prilepskaia V.N. Papillomavirusnaia infektsiia. Teoreticheskie i prakticheskie aspekty. GEOTAR-Media, 2018 (in Russian).
5. Koutsky L et al. A Cohort Study of the Risk of Cervical Intraepithelial Neoplasia Grade 2 or 3 in Relation to Papillomavirus Infection. N Engl J Med 1992; 327: 1272–8. DOI: 10.1056/NEJM199210293271804
6. FDA approves expanded use of Gardasil 9 to include individuals 27 through 45 years old. https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm622715.htm
7. Garland SM et al. Quadrivalent vaccine against human papillomavirus to prevent anogenital diseases. N Engl J Med 2007; 356 (19): 1928–43.
8. Joura EA, Leodolter S, Hernandez-Avila M et al. Efficacy of a quadrivalent prophylactic human papillomavirus (types 6, 11, 16, and 18) L1 virus-like-particle vaccine against high-grade vulval and vaginal lesions: a combined analysis of three randomised clinical trials. Lancet 2007; 369: 1693–702.
9. Joura EA. Quadrivalent Vaccine against Human Papillomavirus to Prevent High-Grade Cervical Lesions. N Engl J Med 2007; 356: 1915–27.
10. Drolet M et al. Population-level impact and herd effects following human papillomavirus vaccination programmes: a systematic review and meta-analysis. Lancet Infect Dis 2015; 15: 565–80.
11. Joura EA, Garland SM, Paavonen J et al. Effect of the human papillomavirus (HPV) quadrivalent vaccine in a subgroup of women with cervical and vulvar disease: retrospective pooled analysis of trial data. FUTURE I and II study group. BMJ 2012; 344: e1401.
12. Garland SM, Paavonen J, Jaisamrarn U et al. HPV PATRICIA Study Group, Prior human papillomavirus-16/18 AS04-adjuvanted vaccination prevents recurrent high-grade cervicalintraepithelial neoplasia after definitive surgical therapy: post- hoc analysis from a randomized controlled trial. Int J Cancer 2016; 139 (12): 2812–26.
13. Swedish KA, Factor SH, Goldstone SE. Prevention of recurrent high-grade anal neoplasia with quadrivalent human papillomavirus vaccination of men who have sex with men: a nonconcurrent cohort study. Clin Infect Dis 2012; 54 (7): 891–8.
14. Deshmukh A, Cantor SB, Fenwick E et al. Adjuvant HPV vaccination for anal cancer prevention in HIV-positive men who have sex with men: the time is now. Vaccine 2017; 35 (38): 5102–9.
15. Harper DM. HPV vaccines – Review of the first decade. Gyn Onc 2017; 146: 196–204.
16. Joura EA et al. N Engl J Med 2015; 372: 711–23. Suppl. disease. Abstract MSS 2–5 presented at EUROGIN 2015, Seville, Spain.
17. Steben M. Review of the impact and effectiveness of the Quadrivalent Human Papillomavirus Vaccine: 10 Years of Clinical Experience in Canada. J Obstet Gynaecol Can 2018; 40 (12): 1635–45.
18. Esquerre M, Bouillette-Marussig M. GTL001, a bivalent therapeutic vaccine against human papillomavirus 16 and 18, induces antigen-specific CD8+ T-cell responses leading to tumor regression. PLoS One 2017; 12 (3): e0174038.

Авторы

В.Н. Прилепская*, К.И. Гусаков, Н.М. Назарова

ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. академика В.И. Кулакова» Минздрава России, Москва, Россия
*VPrilepskaya@mail.ru

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Vera N. Prilepskaya*, Kirill I. Gusakov, Niso M. Nazarova

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia
*VPrilepskaya@mail.ru

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