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Вакцинация как эффективный метод профилактики заболеваний шейки матки, ассоциированных с вирусом папилломы человека (обзор литературы)
Вакцинация как эффективный метод профилактики заболеваний шейки матки, ассоциированных с вирусом папилломы человека (обзор литературы)
Прилепская В.Н., Гусаков К.И., Назарова Н.М. Вакцинация как эффективный метод профилактики заболеваний шейки матки, ассоциированных с вирусом папилломы человека (обзор литературы). Гинекология. 2019; 21 (2): 23–27.
DOI: 10.26442/20795696.2019.2.190396
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Аннотация
Роль вируса папилломы человека (ВПЧ) в развитии рака шейки матки (РШМ) и других заболеваний аногенитальной области доказана и общеизвестна. Несмотря на это, ежегодно отмечается рост показателей заболеваемости РШМ. Специфические методы противовирусного лечения ВПЧ не разработаны, а единственным действенным способом предотвращения РШМ и других ВПЧ-ассоциированных заболеваний является профилактика инфицирования. В целом ряде рандомизированных клинических исследований продемонстрирована чрезвычайно высокая (до 100%) эффективность вакцин от ВПЧ. В настоящее время вакцина от ВПЧ одобрена Всемирной организацией здравоохранения и включена в национальные программы иммунизации 86 государств, а в 17 странах применяется гендерно-нейтральная программа, предусматривающая вакцинацию девочек и мальчиков. В клинической практике Австралии, США и странах Европейского союза, в частности в Италии, Германии, Франции, где вакцинация от ВПЧ включена в национальную программу вакцинации, отмечается высокая эффективность вакцинации в течение 10 и более лет после нее.
Ключевые слова: вакцинация, вирус папилломы человека, рак шейки матки.
Key words: vaccination, human papillomavirus, cervical cancer.
Ключевые слова: вакцинация, вирус папилломы человека, рак шейки матки.
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Key words: vaccination, human papillomavirus, cervical cancer.
Полный текст
Список литературы
1. Грецова О.П., Костин А.А. и др. Заболеваемость и смертность от злокачественных новообразований, ассоциированных с вирусом папилломы человека. Исследования и практика в медицине. 2017; 4 (3).
[Gretsova O.P., Kostin A.A. et al. Zabolevaemost' i smertnost' ot zlokachestvennykh novoobrazovanii, assotsiirovannykh s virusom papillomy cheloveka. Issledovaniia i praktika v meditsine. 2017; 4 (3) (in Russian).]
2. Bruni L et al. ICO Information Centre on HPV and Cancer (HPV Information Centre). Human Papillomavirus and Related Diseases in Russian Federation. Summary Report 7 October 2016. http://www.hpvcentre.net/statistics/reports/XWX.pdf.
3. Diego Chouhy et al. Analysis of the genetic diversity and phylogenetic relationships of putative human papillomavirus types. Gen Virol 2015; 94 (11): 2480–8. DOI: 10.1099/vir.0.055137-0
4. Довлетханова Э.Р., Прилепская В.Н. Папилломавирусная инфекция. Теоретические и практические аспекты. ГЭОТАР-Медиа, 2018.
[Dovletkhanova E.R., Prilepskaia V.N. Papillomavirusnaia infektsiia. Teoreticheskie i prakticheskie aspekty. GEOTAR-Media, 2018 (in Russian).]
5. Koutsky L et al. A Cohort Study of the Risk of Cervical Intraepithelial Neoplasia Grade 2 or 3 in Relation to Papillomavirus Infection. N Engl J Med 1992; 327: 1272–8. DOI: 10.1056/NEJM199210293271804
6. FDA approves expanded use of Gardasil 9 to include individuals 27 through 45 years old. https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm622715.htm
7. Garland SM et al. Quadrivalent vaccine against human papillomavirus to prevent anogenital diseases. N Engl J Med 2007; 356 (19): 1928–43.
8. Joura EA, Leodolter S, Hernandez-Avila M et al. Efficacy of a quadrivalent prophylactic human papillomavirus (types 6, 11, 16, and 18) L1 virus-like-particle vaccine against high-grade vulval and vaginal lesions: a combined analysis of three randomised clinical trials. Lancet 2007; 369: 1693–702.
9. Joura EA. Quadrivalent Vaccine against Human Papillomavirus to Prevent High-Grade Cervical Lesions. N Engl J Med 2007; 356: 1915–27.
10. Drolet M et al. Population-level impact and herd effects following human papillomavirus vaccination programmes: a systematic review and meta-analysis. Lancet Infect Dis 2015; 15: 565–80.
11. Joura EA, Garland SM, Paavonen J et al. Effect of the human papillomavirus (HPV) quadrivalent vaccine in a subgroup of women with cervical and vulvar disease: retrospective pooled analysis of trial data. FUTURE I and II study group. BMJ 2012; 344: e1401.
12. Garland SM, Paavonen J, Jaisamrarn U et al. HPV PATRICIA Study Group, Prior human papillomavirus-16/18 AS04-adjuvanted vaccination prevents recurrent high-grade cervicalintraepithelial neoplasia after definitive surgical therapy: post- hoc analysis from a randomized controlled trial. Int J Cancer 2016; 139 (12): 2812–26.
13. Swedish KA, Factor SH, Goldstone SE. Prevention of recurrent high-grade anal neoplasia with quadrivalent human papillomavirus vaccination of men who have sex with men: a nonconcurrent cohort study. Clin Infect Dis 2012; 54 (7): 891–8.
14. Deshmukh A, Cantor SB, Fenwick E et al. Adjuvant HPV vaccination for anal cancer prevention in HIV-positive men who have sex with men: the time is now. Vaccine 2017; 35 (38): 5102–9.
15. Harper DM. HPV vaccines – Review of the first decade. Gyn Onc 2017; 146: 196–204.
16. Joura EA et al. N Engl J Med 2015; 372: 711–23. Suppl. disease. Abstract MSS 2–5 presented at EUROGIN 2015, Seville, Spain.
17. Steben M. Review of the impact and effectiveness of the Quadrivalent Human Papillomavirus Vaccine: 10 Years of Clinical Experience in Canada. J Obstet Gynaecol Can 2018; 40 (12): 1635–45.
18. Esquerre M, Bouillette-Marussig M. GTL001, a bivalent therapeutic vaccine against human papillomavirus 16 and 18, induces antigen-specific CD8+ T-cell responses leading to tumor regression. PLoS One 2017; 12 (3): e0174038.
2. Bruni L et al. ICO Information Centre on HPV and Cancer (HPV Information Centre). Human Papillomavirus and Related Diseases in Russian Federation. Summary Report 7 October 2016. http://www.hpvcentre.net/statistics/reports/XWX.pdf.
3. Diego Chouhy et al. Analysis of the genetic diversity and phylogenetic relationships of putative human papillomavirus types. Gen Virol 2015; 94 (11): 2480–8. DOI: 10.1099/vir.0.055137-0
4. Dovletkhanova E.R., Prilepskaia V.N. Papillomavirusnaia infektsiia. Teoreticheskie i prakticheskie aspekty. GEOTAR-Media, 2018 (in Russian).
5. Koutsky L et al. A Cohort Study of the Risk of Cervical Intraepithelial Neoplasia Grade 2 or 3 in Relation to Papillomavirus Infection. N Engl J Med 1992; 327: 1272–8. DOI: 10.1056/NEJM199210293271804
6. FDA approves expanded use of Gardasil 9 to include individuals 27 through 45 years old. https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm622715.htm
7. Garland SM et al. Quadrivalent vaccine against human papillomavirus to prevent anogenital diseases. N Engl J Med 2007; 356 (19): 1928–43.
8. Joura EA, Leodolter S, Hernandez-Avila M et al. Efficacy of a quadrivalent prophylactic human papillomavirus (types 6, 11, 16, and 18) L1 virus-like-particle vaccine against high-grade vulval and vaginal lesions: a combined analysis of three randomised clinical trials. Lancet 2007; 369: 1693–702.
9. Joura EA. Quadrivalent Vaccine against Human Papillomavirus to Prevent High-Grade Cervical Lesions. N Engl J Med 2007; 356: 1915–27.
10. Drolet M et al. Population-level impact and herd effects following human papillomavirus vaccination programmes: a systematic review and meta-analysis. Lancet Infect Dis 2015; 15: 565–80.
11. Joura EA, Garland SM, Paavonen J et al. Effect of the human papillomavirus (HPV) quadrivalent vaccine in a subgroup of women with cervical and vulvar disease: retrospective pooled analysis of trial data. FUTURE I and II study group. BMJ 2012; 344: e1401.
12. Garland SM, Paavonen J, Jaisamrarn U et al. HPV PATRICIA Study Group, Prior human papillomavirus-16/18 AS04-adjuvanted vaccination prevents recurrent high-grade cervicalintraepithelial neoplasia after definitive surgical therapy: post- hoc analysis from a randomized controlled trial. Int J Cancer 2016; 139 (12): 2812–26.
13. Swedish KA, Factor SH, Goldstone SE. Prevention of recurrent high-grade anal neoplasia with quadrivalent human papillomavirus vaccination of men who have sex with men: a nonconcurrent cohort study. Clin Infect Dis 2012; 54 (7): 891–8.
14. Deshmukh A, Cantor SB, Fenwick E et al. Adjuvant HPV vaccination for anal cancer prevention in HIV-positive men who have sex with men: the time is now. Vaccine 2017; 35 (38): 5102–9.
15. Harper DM. HPV vaccines – Review of the first decade. Gyn Onc 2017; 146: 196–204.
16. Joura EA et al. N Engl J Med 2015; 372: 711–23. Suppl. disease. Abstract MSS 2–5 presented at EUROGIN 2015, Seville, Spain.
17. Steben M. Review of the impact and effectiveness of the Quadrivalent Human Papillomavirus Vaccine: 10 Years of Clinical Experience in Canada. J Obstet Gynaecol Can 2018; 40 (12): 1635–45.
18. Esquerre M, Bouillette-Marussig M. GTL001, a bivalent therapeutic vaccine against human papillomavirus 16 and 18, induces antigen-specific CD8+ T-cell responses leading to tumor regression. PLoS One 2017; 12 (3): e0174038.
[Gretsova O.P., Kostin A.A. et al. Zabolevaemost' i smertnost' ot zlokachestvennykh novoobrazovanii, assotsiirovannykh s virusom papillomy cheloveka. Issledovaniia i praktika v meditsine. 2017; 4 (3) (in Russian).]
2. Bruni L et al. ICO Information Centre on HPV and Cancer (HPV Information Centre). Human Papillomavirus and Related Diseases in Russian Federation. Summary Report 7 October 2016. http://www.hpvcentre.net/statistics/reports/XWX.pdf.
3. Diego Chouhy et al. Analysis of the genetic diversity and phylogenetic relationships of putative human papillomavirus types. Gen Virol 2015; 94 (11): 2480–8. DOI: 10.1099/vir.0.055137-0
4. Довлетханова Э.Р., Прилепская В.Н. Папилломавирусная инфекция. Теоретические и практические аспекты. ГЭОТАР-Медиа, 2018.
[Dovletkhanova E.R., Prilepskaia V.N. Papillomavirusnaia infektsiia. Teoreticheskie i prakticheskie aspekty. GEOTAR-Media, 2018 (in Russian).]
5. Koutsky L et al. A Cohort Study of the Risk of Cervical Intraepithelial Neoplasia Grade 2 or 3 in Relation to Papillomavirus Infection. N Engl J Med 1992; 327: 1272–8. DOI: 10.1056/NEJM199210293271804
6. FDA approves expanded use of Gardasil 9 to include individuals 27 through 45 years old. https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm622715.htm
7. Garland SM et al. Quadrivalent vaccine against human papillomavirus to prevent anogenital diseases. N Engl J Med 2007; 356 (19): 1928–43.
8. Joura EA, Leodolter S, Hernandez-Avila M et al. Efficacy of a quadrivalent prophylactic human papillomavirus (types 6, 11, 16, and 18) L1 virus-like-particle vaccine against high-grade vulval and vaginal lesions: a combined analysis of three randomised clinical trials. Lancet 2007; 369: 1693–702.
9. Joura EA. Quadrivalent Vaccine against Human Papillomavirus to Prevent High-Grade Cervical Lesions. N Engl J Med 2007; 356: 1915–27.
10. Drolet M et al. Population-level impact and herd effects following human papillomavirus vaccination programmes: a systematic review and meta-analysis. Lancet Infect Dis 2015; 15: 565–80.
11. Joura EA, Garland SM, Paavonen J et al. Effect of the human papillomavirus (HPV) quadrivalent vaccine in a subgroup of women with cervical and vulvar disease: retrospective pooled analysis of trial data. FUTURE I and II study group. BMJ 2012; 344: e1401.
12. Garland SM, Paavonen J, Jaisamrarn U et al. HPV PATRICIA Study Group, Prior human papillomavirus-16/18 AS04-adjuvanted vaccination prevents recurrent high-grade cervicalintraepithelial neoplasia after definitive surgical therapy: post- hoc analysis from a randomized controlled trial. Int J Cancer 2016; 139 (12): 2812–26.
13. Swedish KA, Factor SH, Goldstone SE. Prevention of recurrent high-grade anal neoplasia with quadrivalent human papillomavirus vaccination of men who have sex with men: a nonconcurrent cohort study. Clin Infect Dis 2012; 54 (7): 891–8.
14. Deshmukh A, Cantor SB, Fenwick E et al. Adjuvant HPV vaccination for anal cancer prevention in HIV-positive men who have sex with men: the time is now. Vaccine 2017; 35 (38): 5102–9.
15. Harper DM. HPV vaccines – Review of the first decade. Gyn Onc 2017; 146: 196–204.
16. Joura EA et al. N Engl J Med 2015; 372: 711–23. Suppl. disease. Abstract MSS 2–5 presented at EUROGIN 2015, Seville, Spain.
17. Steben M. Review of the impact and effectiveness of the Quadrivalent Human Papillomavirus Vaccine: 10 Years of Clinical Experience in Canada. J Obstet Gynaecol Can 2018; 40 (12): 1635–45.
18. Esquerre M, Bouillette-Marussig M. GTL001, a bivalent therapeutic vaccine against human papillomavirus 16 and 18, induces antigen-specific CD8+ T-cell responses leading to tumor regression. PLoS One 2017; 12 (3): e0174038.
________________________________________________
2. Bruni L et al. ICO Information Centre on HPV and Cancer (HPV Information Centre). Human Papillomavirus and Related Diseases in Russian Federation. Summary Report 7 October 2016. http://www.hpvcentre.net/statistics/reports/XWX.pdf.
3. Diego Chouhy et al. Analysis of the genetic diversity and phylogenetic relationships of putative human papillomavirus types. Gen Virol 2015; 94 (11): 2480–8. DOI: 10.1099/vir.0.055137-0
4. Dovletkhanova E.R., Prilepskaia V.N. Papillomavirusnaia infektsiia. Teoreticheskie i prakticheskie aspekty. GEOTAR-Media, 2018 (in Russian).
5. Koutsky L et al. A Cohort Study of the Risk of Cervical Intraepithelial Neoplasia Grade 2 or 3 in Relation to Papillomavirus Infection. N Engl J Med 1992; 327: 1272–8. DOI: 10.1056/NEJM199210293271804
6. FDA approves expanded use of Gardasil 9 to include individuals 27 through 45 years old. https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm622715.htm
7. Garland SM et al. Quadrivalent vaccine against human papillomavirus to prevent anogenital diseases. N Engl J Med 2007; 356 (19): 1928–43.
8. Joura EA, Leodolter S, Hernandez-Avila M et al. Efficacy of a quadrivalent prophylactic human papillomavirus (types 6, 11, 16, and 18) L1 virus-like-particle vaccine against high-grade vulval and vaginal lesions: a combined analysis of three randomised clinical trials. Lancet 2007; 369: 1693–702.
9. Joura EA. Quadrivalent Vaccine against Human Papillomavirus to Prevent High-Grade Cervical Lesions. N Engl J Med 2007; 356: 1915–27.
10. Drolet M et al. Population-level impact and herd effects following human papillomavirus vaccination programmes: a systematic review and meta-analysis. Lancet Infect Dis 2015; 15: 565–80.
11. Joura EA, Garland SM, Paavonen J et al. Effect of the human papillomavirus (HPV) quadrivalent vaccine in a subgroup of women with cervical and vulvar disease: retrospective pooled analysis of trial data. FUTURE I and II study group. BMJ 2012; 344: e1401.
12. Garland SM, Paavonen J, Jaisamrarn U et al. HPV PATRICIA Study Group, Prior human papillomavirus-16/18 AS04-adjuvanted vaccination prevents recurrent high-grade cervicalintraepithelial neoplasia after definitive surgical therapy: post- hoc analysis from a randomized controlled trial. Int J Cancer 2016; 139 (12): 2812–26.
13. Swedish KA, Factor SH, Goldstone SE. Prevention of recurrent high-grade anal neoplasia with quadrivalent human papillomavirus vaccination of men who have sex with men: a nonconcurrent cohort study. Clin Infect Dis 2012; 54 (7): 891–8.
14. Deshmukh A, Cantor SB, Fenwick E et al. Adjuvant HPV vaccination for anal cancer prevention in HIV-positive men who have sex with men: the time is now. Vaccine 2017; 35 (38): 5102–9.
15. Harper DM. HPV vaccines – Review of the first decade. Gyn Onc 2017; 146: 196–204.
16. Joura EA et al. N Engl J Med 2015; 372: 711–23. Suppl. disease. Abstract MSS 2–5 presented at EUROGIN 2015, Seville, Spain.
17. Steben M. Review of the impact and effectiveness of the Quadrivalent Human Papillomavirus Vaccine: 10 Years of Clinical Experience in Canada. J Obstet Gynaecol Can 2018; 40 (12): 1635–45.
18. Esquerre M, Bouillette-Marussig M. GTL001, a bivalent therapeutic vaccine against human papillomavirus 16 and 18, induces antigen-specific CD8+ T-cell responses leading to tumor regression. PLoS One 2017; 12 (3): e0174038.
Авторы
В.Н. Прилепская*, К.И. Гусаков, Н.М. Назарова
ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. академика В.И. Кулакова» Минздрава России, Москва, Россия
*VPrilepskaya@mail.ru
V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia
*VPrilepskaya@mail.ru
ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. академика В.И. Кулакова» Минздрава России, Москва, Россия
*VPrilepskaya@mail.ru
________________________________________________
V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia
*VPrilepskaya@mail.ru
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