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Хронический эндометрит у женщин с эндометриоз-ассоциированным бесплодием
Хронический эндометрит у женщин с эндометриоз-ассоциированным бесплодием
Оразов М.Р., Радзинский В.Е., Волкова С.В. и др. Хронический эндометрит у женщин с эндометриоз-ассоциированным бесплодием. Гинекология. 2020; 22 (3): 15–20. DOI: 10.26442/20795696.2020.3.200174
DOI: 10.26442/20795696.2020.3.200174
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DOI: 10.26442/20795696.2020.3.200174
Материалы доступны только для специалистов сферы здравоохранения. Авторизуйтесь или зарегистрируйтесь.
Аннотация
В статье освещены современные представления о роли эндометрия в генезе репродуктивных неудач. Отмечено принципиально важное место хронического эндометрита в структуре эндометриального фактора бесплодия при эндометриозе. Учитывая частую ассоциацию хронического эндометрита и эндометриоза, выявлены общие черты этих заболеваний. Дана характеристика микробиоты эндометрия при бесплодии, хроническом эндометрите и эндометриозе. Крайне важным направлением научного поиска является именно взаимодействие между микробиотой эндометрия и его иммунитетом, а не просто подтверждение присутствия микроорганизмов в эндометрии. Описаны современные аспекты этиологии и патогенеза хронического эндометрита и эндометриоза. Основными патогенетическими детерминантами хронического эндометрита являются срыв механизмов адаптации к постоянному воздействию микробов и, как следствие этого, снижение и неполноценность иммунного ответа и развитие аутоиммунных реакций. Современная парадигма развития и прогрессирования эндометриоза предусматривает наличие бактериальной контаминации эндометрия и брюшной полости, что, в свою очередь, становится триггером генетически-эпигенетических модификаций клеток, запуская разные каскады, лежащие в основе нарушений репродуктивной функции. Освещена патогенетически значимая взаимосвязь хронического эндометрита и эндометриоза. Выявлено, что хронический эндометрит может быть как причиной, так и следствием эндометриоза. Описаны нарушения рецептивности эндометрия при хроническом эндометрите, ассоциированном с эндометриозом, их значение в реализации эндометриального бесплодия. Отмечена важная роль микробиома в формировании репродуктивных нарушений.
Ключевые слова: хронический эндометрит, эндометриоз, микробиота эндометрия, рецептивность эндометрия
Key words: chronic endometritis, endometriosis, endometrial microbiota, endometrial receptivity.
Ключевые слова: хронический эндометрит, эндометриоз, микробиота эндометрия, рецептивность эндометрия
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Key words: chronic endometritis, endometriosis, endometrial microbiota, endometrial receptivity.
Полный текст
Список литературы
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3. Orazov M.R., Hamoshina M.B., Mihaleva L.M. et al. Molekulyarno-geneticheskie osobennosti sostoyaniya endometriya pri endometrioz-associirovannom besplodii. Trudnyj pacient. 2020; 1 (18): 23–32 (in Russian).
4. Lessey BA, Kim JJ. Endometrial Receptivity in Eutopic Endometrium of Women with Endometriosis It is affected, let me show you why. Fertil Steril 2017; 108 (1): 19–27.
5. Evans-Hoeker E, Lessey BA, Jeong JW et al. Endometrial BCL6 Overexpression in Eutopic Endometrium of Women With Endometriosis. Reprod Sci 2016; 23: 1234–41.
6. Lessey BA, Young SL. What exactly is endometrial receptivity? Fertil Steril 2019; 111 (4): 611–17.
7. Tai FW, Chang CY, Chiang JH et al. Association of Pelvic Inflammatory Disease with Risk of Endometriosis: A Nationwide Cohort Study Involving 141, 460 Individuals. J Clin Med 2018; 7 (11).
8. Takebayashi A, Kimura F, Kishi Y et al. The association between endometriosis and chronic endometritis. PLoS One 2014; 9 (2): e88354.
9. Cicinelli E, Trojano G, Mastromauro M et al. Higher prevalence of chronic endometritis in women with endometriosis: a possible etiopathogenetic link. Fertil Steril 2017; 108 (2): 289-295.e1.
10. Tolibova G.Kh., Tral' T.G., Iarmolinskaia M.I., Tsypurdeeva A.A. Endometrial'naia disfunktsiia u patsientok s besplodiem, assotsiirovannym s naruzhnym genital'nym endometriozom. Zhurn. akusherstva i zhenskikh boleznei. 2017; 66: 84–5 (in Russian).
11. Pinto V, Matteo M, Tinelli R et al. Altered uterine contractility in women with chronic endometritis. Fertil Steril 2015; 103 (4): 1049–52.
12. Verstraelen H, Vilchez-Vargas R, Desimpel F et al. Characterisation of the human uterine microbiome in non-pregnant women through deep sequencing of the V1-2 region of the 16S rRNA gene. Peer J 2016; 4: e1602.
13. Mitchell CM, Haick A, Nkwopara E et al. Colonization of the upper genital tract by vaginal bacterial species in nonpregnant women. Am J Obstet Gynecol 2015; 212: 611.e1–9.
14. Mlodzik N, Lukaszuk K, Sieg W et al. Endometrial microbiota – do they mean more than we have expected? Ginekol Pol 2020; 91 (1): 45–8.
15. Moreno I, Codoñer FM, Vilella F et al. Evidence that the endometrial microbiota has an effect on implantation success or failure. Am J Obstet Gynecol 2016; 215 (6): 684–703.
16. Kyono K, Hashimoto T, Nagai Y, Sakuraba Y. Analysis of endometrial microbiota by 16S ribosomal RNA gene sequencing among infertile patients: a single-center pilot study. Reprod Med Biol 2018; 17 (3): 297–306.
17. Cicinelli E, De Ziegler D, Nicoletti R et al. Poor reliability of vaginal and endocervical cultures for evaluating microbiology of endometrial cavity in women with chronic endometritis. Gynecol Obstet Invest 2009; 68: 108–15.
18. Cicinelli E, Matteo M, Tinelli R et al. Chronic endometritis due to common bacteria is prevalent in women with recurrent miscarriage as confirmed by improved pregnancy outcome after antibiotic treatment. Reprod Sci 2014; 21: 640–7.
19. Liu Y, Ko EY, Wong KK et al. Endometrial microbiota in infertile women with and without chronic endometritis as diagnosed using a quantitative and reference range-based method. Fertil Steril 2019; 112 (4): 707-717.e1.
20. Wang RL, Chen LX, Shu WS et al. Barcoded sequencing reveals diverse intrauterine microbiomes in patients suffering with endometrial polyps. Am J Transl Res 2016; 8: 1581–92.
21. Petrov Iu.A. Rol' mikrobnogo faktora v geneze khronicheskogo endometrita. Kubanskii nauchnyi meditsinskii vestnik. 2016; 3 (158): 113–8 (in Russian).
22. Baker JM, Chase DM, Herbst-Kralovetz MM. Uterine microbiota: Residents, tourists, or invaders? Front Immunol 2018; 9: 208.
23. Resta L, Palumbo M, Piscitelli D et al. Histology of micro polyps in chronic endometritis. Histopathology 2012; 60 (4): 670–4.
24. Kitaya K, Takeuchi T, Mizuta S et al. Endometritis: new time, new concepts. Fertil Steril 2018: 110 (3); 344–50.
25. Kitaya K, Yasuo T. Aberrant expression of selectin E, CXCL1, and CXCL13 in chronic endometritis. Mod Pathol 2010; 23 (8): 1136–46.
26. Kitaya K, Matsubayashi H, Yamaguchi K et al. Chronic endometritis: potential cause of infertility and obstetric and neonatal complications. Am J Reprod Immunol 2016; 75 (1): 13–22.
27. Kitaya K, Tada Y, Hayashi T et al. Comprehensive endometrial immunoglobulin subclass analysis in infertile women suffering from repeated implantation failure with or without chronic endometritis. Am J Reprod Immunol 2014; 72 (4): 386–91.
28. Di Pietro C, Cicinelli E, Guglielmino MR et al. Altered transcriptional regulation of cytokines, growth factors, and apoptotic proteins in the endometrium of infertile women with chronic endometritis. Am J Reprod Immunol 2013; 6 9(5): 509–17.
29. Wu D, Kimura F, Zheng L et al. Chronic endometritis modifies decidualization in human endometrial stromal cells. Reprod Biol Endocrinol 2017; 15 (1): 16.
30. Kitaya K, Yasuo T, Tada Y et al. Unusual inflammation in gynecologic pathology associated with defective endometrial receptivity. Histol Histopathol 2014; 29 (9): 1113–27.
31. Vatansever HS, Lacin S, Ozbilgin MK. Changed Bcl: Bax ratio in endometrium of patients with unexplained infertility. Acta Histochem 2005; 107 (5): 345–55.
32. Radzinskii V.E., Petrov Iu.A., Kalinina E.A. et al. Patogeneticheskie osobennosti makrotipov khronicheskogo endometrita. Kazanskii med. zhurn. 2017; 98 (1): 27–34 (in Russian)
33. Bessudnova I.Iu., Kozhevnikova E.S. Varianty lecheniia khronicheskogo endometrita u patsientok s besplodiem i nevynashivaniem beremennosti. Zhurn. akusherstva i zhenskikh boleznei. 2016; 65: 60–2 (in Russian)
34. Amrieva D.Kh., Petrov Iu.A. Khronicheskii endometrit: patogeneticheskie aspekty. Vestn. DGMA. 2019; 4 (33): 59–63 (in Russian).
35. Khan KN, Kitajima M, Hiraki K et al. Escherichia coli contamination of menstrual blood and effect of bacterial endotoxin on endometriosis. Fertil Steril 2010; 94: 2860–3.
36. Orazov M.R., Toktar L.R. Bakterial'naia kontaminatsiia: novoe slovo v patogeneze endometrioza. Akusherstvo i ginekologiia: novosti, mneniia, obuchenie. 2018; 6 (3): 29–37 (in Russian).
37. Khan KN, Fujishita A, Kitajima M et al. Intrauterine microbial colonization and occurrence of endometritis in women with endometriosis. Hum Reprod 2014; 29: 2446–56.
38. Moreno I, Franasiak JM. Endometrial microbiota-new player in town. Fertil Steril 2017; 108 (1): 32–9.
39. Khan KN, Fujishita A, Hiraki K et al. Bacterial contamination hypothesis: a new concept in endometriosis. Reprod Med Biol 2018; 17 (2): 125–133.
40. Khan KN, Kitajima M, Imamura T et al. Toll-like receptor 4 (TLR4)- mediated growth of endometriosis by human heat shock protein 70(Hsp70). Hum Reprod 2008; 23: 2210–9.
41. Koninckx PR, Ussia A, Adamyan L et al. Pathogenesis of endometriosis: the genetic/epigenetic theory. Fertil Steril 2019; 111 (2): 327–40.
42. Koninckx PR, Ussia A, Tahlak M et al. Infection as a potential cofactor in the genetic-epigenetic pathophysiology of endometriosis: a systematic review. Facts Views Vis Obgyn 2019; 11 (3): 209–16.
43. Sukhikh G.T., Shurshalina A.V. Khronicheskii endometrit: rukovodstvo. Moscow: GEOTAR-Media, 2013 (in Russian)
44. Tolibova G.Kh., Tral' T.G., Ailamazian E.K., Kogan I.Iu. Molekuliarnye mekhanizmy tsiklicheskoi transformatsii endometriia. Zhurn. akusherstva i zhenskikh boleznei. 2019; 68 (1): 5–12 (in Russian)
45. Tolibova G.Kh., Tral' T.G., Kleshchev M.A. et al. Endometrial'naia disfunktsiia: algoritm gistologicheskogo i immunogistokhimicheskogo issledovaniia. Zhurn. akusherstva i zhenskikh boleznei. 2015; 64 (4): 69–77 (in Russian)
46. Osiński M, Wirstlein P, Wender-Ożegowska E et al. HSD3B2, HSD17B1, HSD17B2, ESR1, ESR2 and AR expression in infertile women with endometriosis. Ginekol Pol 2018; 89 (3): 125–34.
47. Ryan M. Marquardt, Tae Hoon Kim, Jung-Ho Shin, Jae-Wook Jeong. Progesterone and Estrogen Signaling in the Endometrium: What Goes Wrong in Endometriosis? Int J Mol Sci 2019; 20 (15): 3822.
48. Wölfler MM, Küppers M, Rath W et al. Altered expression of progesterone receptor isoforms A and B in human eutopic endometrium in endometriosis patients. Ann Anat 2016; 206: 1–6.
49. Puente E, Alonso L, Laganà AS et al. Chronic Endometritis: Old Problem, Novel Insights and Future Challenges. Int J Fertil Steril 2020; 13 (4): 250–6.
50. Zainetdinova L.F., Koriaushkina A.V., Telesheva L.F., Sychugov G.V. Osobennosti protsessov kletochnogo obnovleniia v eutopicheskom endometrii u zhenshchin s naruzhnym genital'nym endometriozom i khronicheskim endometritom. Ural'skii med. zhurn. 2020; 3 (186): 71–7 (in Russian).
51. Bulun SE, Yilmaz BD, Sison C et al. Endometriosis. Endocr Rev. 2019;
40 (4): 1048–79.
2. Kimura F, Takebayashi A, Ishida M et al. Review: Chronic endometritis and its effect on reproduction. J Obstet Gynaecol Res 2019; 45 (5): 951–60.
3. Оразов М.Р., Хамошина М.Б., Михалева Л.М. и др. Молекулярно-генетические особенности состояния эндометрия при эндометриоз-ассоциированном бесплодии. Трудный пациент. 2020; 1 (18): 23–32.
[Orazov M.R., Hamoshina M.B., Mihaleva L.M. et al. Molekulyarno-geneticheskie osobennosti sostoyaniya endometriya pri endometrioz-associirovannom besplodii. Trudnyj pacient. 2020; 1 (18): 23–32 (in Russian).]
4. Lessey BA, Kim JJ. Endometrial Receptivity in Eutopic Endometrium of Women with Endometriosis It is affected, let me show you why. Fertil Steril 2017; 108 (1): 19–27.
5. Evans-Hoeker E, Lessey BA, Jeong JW et al. Endometrial BCL6 Overexpression in Eutopic Endometrium of Women With Endometriosis. Reprod Sci 2016; 23: 1234–41.
6. Lessey BA, Young SL. What exactly is endometrial receptivity? Fertil Steril 2019; 111 (4): 611–17.
7. Tai FW, Chang CY, Chiang JH et al. Association of Pelvic Inflammatory Disease with Risk of Endometriosis: A Nationwide Cohort Study Involving 141, 460 Individuals. J Clin Med 2018; 7 (11).
8. Takebayashi A, Kimura F, Kishi Y et al. The association between endometriosis and chronic endometritis. PLoS One 2014; 9 (2): e88354.
9. Cicinelli E, Trojano G, Mastromauro M et al. Higher prevalence of chronic endometritis in women with endometriosis: a possible etiopathogenetic link. Fertil Steril 2017; 108 (2): 289-295.e1.
10. Толибова Г.Х., Траль Т.Г., Ярмолинская М.И., Цыпурдеева А.А. Эндометриальная дисфункция у пациенток с бесплодием, ассоциированным с наружным генитальным эндометриозом. Журн. акушерства и женских болезней. 2017; 66: 84–5.
[Tolibova G.Kh., Tral' T.G., Iarmolinskaia M.I., Tsypurdeeva A.A. Endometrial'naia disfunktsiia u patsientok s besplodiem, assotsiirovannym s naruzhnym genital'nym endometriozom. Zhurn. akusherstva i zhenskikh boleznei. 2017; 66: 84–5 (in Russian).]
11. Pinto V, Matteo M, Tinelli R et al. Altered uterine contractility in women with chronic endometritis. Fertil Steril 2015; 103 (4): 1049–52.
12. Verstraelen H, Vilchez-Vargas R, Desimpel F et al. Characterisation of the human uterine microbiome in non-pregnant women through deep sequencing of the V1-2 region of the 16S rRNA gene. Peer J 2016; 4: e1602.
13. Mitchell CM, Haick A, Nkwopara E et al. Colonization of the upper genital tract by vaginal bacterial species in nonpregnant women. Am J Obstet Gynecol 2015; 212: 611.e1–9.
14. Mlodzik N, Lukaszuk K, Sieg W et al. Endometrial microbiota – do they mean more than we have expected? Ginekol Pol 2020; 91 (1): 45–8.
15. Moreno I, Codoñer FM, Vilella F et al. Evidence that the endometrial microbiota has an effect on implantation success or failure. Am J Obstet Gynecol 2016; 215 (6): 684–703.
16. Kyono K, Hashimoto T, Nagai Y, Sakuraba Y. Analysis of endometrial microbiota by 16S ribosomal RNA gene sequencing among infertile patients: a single-center pilot study. Reprod Med Biol 2018; 17 (3): 297–306.
17. Cicinelli E, De Ziegler D, Nicoletti R et al. Poor reliability of vaginal and endocervical cultures for evaluating microbiology of endometrial cavity in women with chronic endometritis. Gynecol Obstet Invest 2009; 68: 108–15.
18. Cicinelli E, Matteo M, Tinelli R et al. Chronic endometritis due to common bacteria is prevalent in women with recurrent miscarriage as confirmed by improved pregnancy outcome after antibiotic treatment. Reprod Sci 2014; 21: 640–7.
19. Liu Y, Ko EY, Wong KK et al. Endometrial microbiota in infertile women with and without chronic endometritis as diagnosed using a quantitative and reference range-based method. Fertil Steril 2019; 112 (4): 707-717.e1.
20. Wang RL, Chen LX, Shu WS et al. Barcoded sequencing reveals diverse intrauterine microbiomes in patients suffering with endometrial polyps. Am J Transl Res 2016; 8: 1581–92.
21. Петров Ю.А. Роль микробного фактора в генезе хронического эндометрита. Кубанский научный медицинский вестник. 2016; 3 (158): 113–8.
[Petrov Iu.A. Rol' mikrobnogo faktora v geneze khronicheskogo endometrita. Kubanskii nauchnyi meditsinskii vestnik. 2016; 3 (158): 113–8 (in Russian).]
22. Baker JM, Chase DM, Herbst-Kralovetz MM. Uterine microbiota: Residents, tourists, or invaders? Front Immunol 2018; 9: 208.
23. Resta L, Palumbo M, Piscitelli D et al. Histology of micro polyps in chronic endometritis. Histopathology 2012; 60 (4): 670–4.
24. Kitaya K, Takeuchi T, Mizuta S et al. Endometritis: new time, new concepts. Fertil Steril 2018: 110 (3); 344–50.
25. Kitaya K, Yasuo T. Aberrant expression of selectin E, CXCL1, and CXCL13 in chronic endometritis. Mod Pathol 2010; 23 (8): 1136–46.
26. Kitaya K, Matsubayashi H, Yamaguchi K et al. Chronic endometritis: potential cause of infertility and obstetric and neonatal complications. Am J Reprod Immunol 2016; 75 (1): 13–22.
27. Kitaya K, Tada Y, Hayashi T et al. Comprehensive endometrial immunoglobulin subclass analysis in infertile women suffering from repeated implantation failure with or without chronic endometritis. Am J Reprod Immunol 2014; 72 (4): 386–91.
28. Di Pietro C, Cicinelli E, Guglielmino MR et al. Altered transcriptional regulation of cytokines, growth factors, and apoptotic proteins in the endometrium of infertile women with chronic endometritis. Am J Reprod Immunol 2013; 6 9(5): 509–17.
29. Wu D, Kimura F, Zheng L et al. Chronic endometritis modifies decidualization in human endometrial stromal cells. Reprod Biol Endocrinol 2017; 15 (1): 16.
30. Kitaya K, Yasuo T, Tada Y et al. Unusual inflammation in gynecologic pathology associated with defective endometrial receptivity. Histol Histopathol 2014; 29 (9): 1113–27.
31. Vatansever HS, Lacin S, Ozbilgin MK. Changed Bcl: Bax ratio in endometrium of patients with unexplained infertility. Acta Histochem 2005; 107 (5): 345–55.
32. Радзинский В.Е., Петров Ю.А., Калинина Е.А. и др. Патогенетические особенности макротипов хронического эндометрита. Казанский мед. журн. 2017; 98 (1): 27–34.
[Radzinskii V.E., Petrov Iu.A., Kalinina E.A. et al. Patogeneticheskie osobennosti makrotipov khronicheskogo endometrita. Kazanskii med. zhurn. 2017; 98 (1): 27–34 (in Russian)].
33. Бессуднова И.Ю., Кожевникова Е.С. Варианты лечения хронического эндометрита у пациенток с бесплодием и невынашиванием беременности. Журн. акушерства и женских болезней. 2016; 65: 60–2.
[Bessudnova I.Iu., Kozhevnikova E.S. Varianty lecheniia khronicheskogo endometrita u patsientok s besplodiem i nevynashivaniem beremennosti. Zhurn. akusherstva i zhenskikh boleznei. 2016; 65: 60–2 (in Russian)].
34. Амриева Д.Х., Петров Ю.А. Хронический эндометрит: патогенетические аспекты. Вестн. ДГМА. 2019; 4 (33): 59–63.
[Amrieva D.Kh., Petrov Iu.A. Khronicheskii endometrit: patogeneticheskie aspekty. Vestn. DGMA. 2019; 4 (33): 59–63 (in Russian).]
35. Khan KN, Kitajima M, Hiraki K et al. Escherichia coli contamination of menstrual blood and effect of bacterial endotoxin on endometriosis. Fertil Steril 2010; 94: 2860–3.
36. Оразов М.Р., Токтар Л.Р. Бактериальная контаминация: новое слово в патогенезе эндометриоза. Акушерство и гинекология: новости, мнения, обучение. 2018; 6 (3): 29–37.
[Orazov M.R., Toktar L.R. Bakterial'naia kontaminatsiia: novoe slovo v patogeneze endometrioza. Akusherstvo i ginekologiia: novosti, mneniia, obuchenie. 2018; 6 (3): 29–37 (in Russian).]
37. Khan KN, Fujishita A, Kitajima M et al. Intrauterine microbial colonization and occurrence of endometritis in women with endometriosis. Hum Reprod 2014; 29: 2446–56.
38. Moreno I, Franasiak JM. Endometrial microbiota-new player in town. Fertil Steril 2017; 108 (1): 32–9.
39. Khan KN, Fujishita A, Hiraki K et al. Bacterial contamination hypothesis: a new concept in endometriosis. Reprod Med Biol 2018; 17 (2): 125–133.
40. Khan KN, Kitajima M, Imamura T et al. Toll-like receptor 4 (TLR4)- mediated growth of endometriosis by human heat shock protein 70(Hsp70). Hum Reprod 2008; 23: 2210–9.
41. Koninckx PR, Ussia A, Adamyan L et al. Pathogenesis of endometriosis: the genetic/epigenetic theory. Fertil Steril 2019; 111 (2): 327–40.
42. Koninckx PR, Ussia A, Tahlak M et al. Infection as a potential cofactor in the genetic-epigenetic pathophysiology of endometriosis: a systematic review. Facts Views Vis Obgyn 2019; 11 (3): 209–16.
43. Сухих Г.Т., Шуршалина А.В. Хронический эндометрит: руководство. М.: ГЭОТАР-Медиа, 2013.
[Sukhikh G.T., Shurshalina A.V. Khronicheskii endometrit: rukovodstvo. Moscow: GEOTAR-Media, 2013 (in Russian)].
44. Толибова Г.Х., Траль Т.Г., Айламазян Э.К., Коган И.Ю. Молекулярные механизмы циклической трансформации эндометрия. Журн. акушерства и женских болезней. 2019; 68 (1): 5–12.
[Tolibova G.Kh., Tral' T.G., Ailamazian E.K., Kogan I.Iu. Molekuliarnye mekhanizmy tsiklicheskoi transformatsii endometriia. Zhurn. akusherstva i zhenskikh boleznei. 2019; 68 (1): 5–12 (in Russian)].
45. Толибова Г.Х., Траль Т.Г., Клещев М.А. и др. Эндометриальная дисфункция: алгоритм гистологического и иммуногистохимического исследования. Журн. акушерства и женских болезней. 2015; 64 (4): 69–77.
[Tolibova G.Kh., Tral' T.G., Kleshchev M.A. et al. Endometrial'naia disfunktsiia: algoritm gistologicheskogo i immunogistokhimicheskogo issledovaniia. Zhurn. akusherstva i zhenskikh boleznei. 2015; 64 (4): 69–77 (in Russian)].
46. Osiński M, Wirstlein P, Wender-Ożegowska E et al. HSD3B2, HSD17B1, HSD17B2, ESR1, ESR2 and AR expression in infertile women with endometriosis. Ginekol Pol 2018; 89 (3): 125–34.
47. Ryan M. Marquardt, Tae Hoon Kim, Jung-Ho Shin, Jae-Wook Jeong. Progesterone and Estrogen Signaling in the Endometrium: What Goes Wrong in Endometriosis? Int J Mol Sci 2019; 20 (15): 3822.
48. Wölfler MM, Küppers M, Rath W et al. Altered expression of progesterone receptor isoforms A and B in human eutopic endometrium in endometriosis patients. Ann Anat 2016; 206: 1–6.
49. Puente E, Alonso L, Laganà AS et al. Chronic Endometritis: Old Problem, Novel Insights and Future Challenges. Int J Fertil Steril 2020; 13 (4): 250–6.
50. Зайнетдинова Л.Ф., Коряушкина А.В., Телешева Л.Ф., Сычугов Г.В. Особенности процессов клеточного обновления в эутопическом эндометрии у женщин с наружным генитальным эндометриозом и хроническим эндометритом. Уральский мед. журн. 2020; 3 (186): 71–7.
[Zainetdinova L.F., Koriaushkina A.V., Telesheva L.F., Sychugov G.V. Osobennosti protsessov kletochnogo obnovleniia v eutopicheskom endometrii u zhenshchin s naruzhnym genital'nym endometriozom i khronicheskim endometritom. Ural'skii med. zhurn. 2020; 3 (186): 71–7 (in Russian).]
51. Bulun SE, Yilmaz BD, Sison C et al. Endometriosis. Endocr Rev. 2019;
40 (4): 1048–79.
________________________________________________
2. Kimura F, Takebayashi A, Ishida M et al. Review: Chronic endometritis and its effect on reproduction. J Obstet Gynaecol Res 2019; 45 (5): 951–60.
3. Orazov M.R., Hamoshina M.B., Mihaleva L.M. et al. Molekulyarno-geneticheskie osobennosti sostoyaniya endometriya pri endometrioz-associirovannom besplodii. Trudnyj pacient. 2020; 1 (18): 23–32 (in Russian).
4. Lessey BA, Kim JJ. Endometrial Receptivity in Eutopic Endometrium of Women with Endometriosis It is affected, let me show you why. Fertil Steril 2017; 108 (1): 19–27.
5. Evans-Hoeker E, Lessey BA, Jeong JW et al. Endometrial BCL6 Overexpression in Eutopic Endometrium of Women With Endometriosis. Reprod Sci 2016; 23: 1234–41.
6. Lessey BA, Young SL. What exactly is endometrial receptivity? Fertil Steril 2019; 111 (4): 611–17.
7. Tai FW, Chang CY, Chiang JH et al. Association of Pelvic Inflammatory Disease with Risk of Endometriosis: A Nationwide Cohort Study Involving 141, 460 Individuals. J Clin Med 2018; 7 (11).
8. Takebayashi A, Kimura F, Kishi Y et al. The association between endometriosis and chronic endometritis. PLoS One 2014; 9 (2): e88354.
9. Cicinelli E, Trojano G, Mastromauro M et al. Higher prevalence of chronic endometritis in women with endometriosis: a possible etiopathogenetic link. Fertil Steril 2017; 108 (2): 289-295.e1.
10. Tolibova G.Kh., Tral' T.G., Iarmolinskaia M.I., Tsypurdeeva A.A. Endometrial'naia disfunktsiia u patsientok s besplodiem, assotsiirovannym s naruzhnym genital'nym endometriozom. Zhurn. akusherstva i zhenskikh boleznei. 2017; 66: 84–5 (in Russian).
11. Pinto V, Matteo M, Tinelli R et al. Altered uterine contractility in women with chronic endometritis. Fertil Steril 2015; 103 (4): 1049–52.
12. Verstraelen H, Vilchez-Vargas R, Desimpel F et al. Characterisation of the human uterine microbiome in non-pregnant women through deep sequencing of the V1-2 region of the 16S rRNA gene. Peer J 2016; 4: e1602.
13. Mitchell CM, Haick A, Nkwopara E et al. Colonization of the upper genital tract by vaginal bacterial species in nonpregnant women. Am J Obstet Gynecol 2015; 212: 611.e1–9.
14. Mlodzik N, Lukaszuk K, Sieg W et al. Endometrial microbiota – do they mean more than we have expected? Ginekol Pol 2020; 91 (1): 45–8.
15. Moreno I, Codoñer FM, Vilella F et al. Evidence that the endometrial microbiota has an effect on implantation success or failure. Am J Obstet Gynecol 2016; 215 (6): 684–703.
16. Kyono K, Hashimoto T, Nagai Y, Sakuraba Y. Analysis of endometrial microbiota by 16S ribosomal RNA gene sequencing among infertile patients: a single-center pilot study. Reprod Med Biol 2018; 17 (3): 297–306.
17. Cicinelli E, De Ziegler D, Nicoletti R et al. Poor reliability of vaginal and endocervical cultures for evaluating microbiology of endometrial cavity in women with chronic endometritis. Gynecol Obstet Invest 2009; 68: 108–15.
18. Cicinelli E, Matteo M, Tinelli R et al. Chronic endometritis due to common bacteria is prevalent in women with recurrent miscarriage as confirmed by improved pregnancy outcome after antibiotic treatment. Reprod Sci 2014; 21: 640–7.
19. Liu Y, Ko EY, Wong KK et al. Endometrial microbiota in infertile women with and without chronic endometritis as diagnosed using a quantitative and reference range-based method. Fertil Steril 2019; 112 (4): 707-717.e1.
20. Wang RL, Chen LX, Shu WS et al. Barcoded sequencing reveals diverse intrauterine microbiomes in patients suffering with endometrial polyps. Am J Transl Res 2016; 8: 1581–92.
21. Petrov Iu.A. Rol' mikrobnogo faktora v geneze khronicheskogo endometrita. Kubanskii nauchnyi meditsinskii vestnik. 2016; 3 (158): 113–8 (in Russian).
22. Baker JM, Chase DM, Herbst-Kralovetz MM. Uterine microbiota: Residents, tourists, or invaders? Front Immunol 2018; 9: 208.
23. Resta L, Palumbo M, Piscitelli D et al. Histology of micro polyps in chronic endometritis. Histopathology 2012; 60 (4): 670–4.
24. Kitaya K, Takeuchi T, Mizuta S et al. Endometritis: new time, new concepts. Fertil Steril 2018: 110 (3); 344–50.
25. Kitaya K, Yasuo T. Aberrant expression of selectin E, CXCL1, and CXCL13 in chronic endometritis. Mod Pathol 2010; 23 (8): 1136–46.
26. Kitaya K, Matsubayashi H, Yamaguchi K et al. Chronic endometritis: potential cause of infertility and obstetric and neonatal complications. Am J Reprod Immunol 2016; 75 (1): 13–22.
27. Kitaya K, Tada Y, Hayashi T et al. Comprehensive endometrial immunoglobulin subclass analysis in infertile women suffering from repeated implantation failure with or without chronic endometritis. Am J Reprod Immunol 2014; 72 (4): 386–91.
28. Di Pietro C, Cicinelli E, Guglielmino MR et al. Altered transcriptional regulation of cytokines, growth factors, and apoptotic proteins in the endometrium of infertile women with chronic endometritis. Am J Reprod Immunol 2013; 6 9(5): 509–17.
29. Wu D, Kimura F, Zheng L et al. Chronic endometritis modifies decidualization in human endometrial stromal cells. Reprod Biol Endocrinol 2017; 15 (1): 16.
30. Kitaya K, Yasuo T, Tada Y et al. Unusual inflammation in gynecologic pathology associated with defective endometrial receptivity. Histol Histopathol 2014; 29 (9): 1113–27.
31. Vatansever HS, Lacin S, Ozbilgin MK. Changed Bcl: Bax ratio in endometrium of patients with unexplained infertility. Acta Histochem 2005; 107 (5): 345–55.
32. Radzinskii V.E., Petrov Iu.A., Kalinina E.A. et al. Patogeneticheskie osobennosti makrotipov khronicheskogo endometrita. Kazanskii med. zhurn. 2017; 98 (1): 27–34 (in Russian)
33. Bessudnova I.Iu., Kozhevnikova E.S. Varianty lecheniia khronicheskogo endometrita u patsientok s besplodiem i nevynashivaniem beremennosti. Zhurn. akusherstva i zhenskikh boleznei. 2016; 65: 60–2 (in Russian)
34. Amrieva D.Kh., Petrov Iu.A. Khronicheskii endometrit: patogeneticheskie aspekty. Vestn. DGMA. 2019; 4 (33): 59–63 (in Russian).
35. Khan KN, Kitajima M, Hiraki K et al. Escherichia coli contamination of menstrual blood and effect of bacterial endotoxin on endometriosis. Fertil Steril 2010; 94: 2860–3.
36. Orazov M.R., Toktar L.R. Bakterial'naia kontaminatsiia: novoe slovo v patogeneze endometrioza. Akusherstvo i ginekologiia: novosti, mneniia, obuchenie. 2018; 6 (3): 29–37 (in Russian).
37. Khan KN, Fujishita A, Kitajima M et al. Intrauterine microbial colonization and occurrence of endometritis in women with endometriosis. Hum Reprod 2014; 29: 2446–56.
38. Moreno I, Franasiak JM. Endometrial microbiota-new player in town. Fertil Steril 2017; 108 (1): 32–9.
39. Khan KN, Fujishita A, Hiraki K et al. Bacterial contamination hypothesis: a new concept in endometriosis. Reprod Med Biol 2018; 17 (2): 125–133.
40. Khan KN, Kitajima M, Imamura T et al. Toll-like receptor 4 (TLR4)- mediated growth of endometriosis by human heat shock protein 70(Hsp70). Hum Reprod 2008; 23: 2210–9.
41. Koninckx PR, Ussia A, Adamyan L et al. Pathogenesis of endometriosis: the genetic/epigenetic theory. Fertil Steril 2019; 111 (2): 327–40.
42. Koninckx PR, Ussia A, Tahlak M et al. Infection as a potential cofactor in the genetic-epigenetic pathophysiology of endometriosis: a systematic review. Facts Views Vis Obgyn 2019; 11 (3): 209–16.
43. Sukhikh G.T., Shurshalina A.V. Khronicheskii endometrit: rukovodstvo. Moscow: GEOTAR-Media, 2013 (in Russian)
44. Tolibova G.Kh., Tral' T.G., Ailamazian E.K., Kogan I.Iu. Molekuliarnye mekhanizmy tsiklicheskoi transformatsii endometriia. Zhurn. akusherstva i zhenskikh boleznei. 2019; 68 (1): 5–12 (in Russian)
45. Tolibova G.Kh., Tral' T.G., Kleshchev M.A. et al. Endometrial'naia disfunktsiia: algoritm gistologicheskogo i immunogistokhimicheskogo issledovaniia. Zhurn. akusherstva i zhenskikh boleznei. 2015; 64 (4): 69–77 (in Russian)
46. Osiński M, Wirstlein P, Wender-Ożegowska E et al. HSD3B2, HSD17B1, HSD17B2, ESR1, ESR2 and AR expression in infertile women with endometriosis. Ginekol Pol 2018; 89 (3): 125–34.
47. Ryan M. Marquardt, Tae Hoon Kim, Jung-Ho Shin, Jae-Wook Jeong. Progesterone and Estrogen Signaling in the Endometrium: What Goes Wrong in Endometriosis? Int J Mol Sci 2019; 20 (15): 3822.
48. Wölfler MM, Küppers M, Rath W et al. Altered expression of progesterone receptor isoforms A and B in human eutopic endometrium in endometriosis patients. Ann Anat 2016; 206: 1–6.
49. Puente E, Alonso L, Laganà AS et al. Chronic Endometritis: Old Problem, Novel Insights and Future Challenges. Int J Fertil Steril 2020; 13 (4): 250–6.
50. Zainetdinova L.F., Koriaushkina A.V., Telesheva L.F., Sychugov G.V. Osobennosti protsessov kletochnogo obnovleniia v eutopicheskom endometrii u zhenshchin s naruzhnym genital'nym endometriozom i khronicheskim endometritom. Ural'skii med. zhurn. 2020; 3 (186): 71–7 (in Russian).
51. Bulun SE, Yilmaz BD, Sison C et al. Endometriosis. Endocr Rev. 2019;
40 (4): 1048–79.
Авторы
М.Р. Оразов*1, В.Е. Радзинский1, С.В. Волкова1, М.Б. Хамошина1, Л.М. Михалева2, М.З. Абитова1, В.Б. Шустова3
1 ФГАОУ ВО «Российский университет дружбы народов», Москва, Россия;
2 ФГБНУ «Научно-исследовательский институт морфологии человека», Москва, Россия;
3 ООО «МедИнСервис» – Центр репродукции и генетики «Nova Clinic» («МедИнСервис»), Москва, Россия
*omekan@mail.ru
1 Peoples' Friendship University of Russia, Moscow, Russia;
2 Research Institute of Human Morphology, Moscow, Russia;
3 MedInService – Center for Reproduction and Genetics “Nova Clinic” (“MedInService”), Moscow, Russia
*omekan@mail.ru
1 ФГАОУ ВО «Российский университет дружбы народов», Москва, Россия;
2 ФГБНУ «Научно-исследовательский институт морфологии человека», Москва, Россия;
3 ООО «МедИнСервис» – Центр репродукции и генетики «Nova Clinic» («МедИнСервис»), Москва, Россия
*omekan@mail.ru
________________________________________________
1 Peoples' Friendship University of Russia, Moscow, Russia;
2 Research Institute of Human Morphology, Moscow, Russia;
3 MedInService – Center for Reproduction and Genetics “Nova Clinic” (“MedInService”), Moscow, Russia
*omekan@mail.ru
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