Материалы доступны только для специалистов сферы здравоохранения. Авторизуйтесь или зарегистрируйтесь.
Роль 7-гидроксиматаирезинола в модуляции метаболизма эстрогенов и терапии мастопатии
Роль 7-гидроксиматаирезинола в модуляции метаболизма эстрогенов и терапии мастопатии
Рубашкина А.Н., Лапочкина Н.П., Торшин И.Ю., Громова О.А. Роль 7-гидроксиматаирезинола в модуляции метаболизма эстрогенов и терапии мастопатии. Гинекология. 2020; 22 (4): 43–48. DOI: 10.26442/20795696.2020.4.200183
________________________________________________
Материалы доступны только для специалистов сферы здравоохранения. Авторизуйтесь или зарегистрируйтесь.
Аннотация
В настоящей работе проведены количественные оценки влияния приема 7-гидроксиматаирезинола (7-hydroxymatairesinol – 7-HMR) на показатели эстрогенового баланса и клинические аспекты течения фиброзно-кистозной мастопатии (ФКМ).
Цель. Оценка эффектов 7-HMR на метаболизм эстрогенов и прогестерона в суточной моче у пациенток с ФКМ в постменопаузальном периоде.
Материалы и методы. Проведен анализ метаболитов эстрогена (16a-ОНЕ1, 2-ОНЕ2, 2-ОНЕ1, 2-ОМеЕ1, 4-ОМеЕ2, 4-ОНЕ1, соотношения 2-ОНЕ1/16a-ОНЕ1,
2-ОНЕ1/2-OMeE1 и 4-OHE1/4-OMeE1) и прогестерона с использованием твердофазного иммуноферментного анализа.
Результаты. Установлено, что прием 7-HMR (60 мг/сут, 1 мес) способствует нормализации метаболизма эстрогенов (снижение эстрадиола, эстрона, эстриола, 16a-ОНЕ1) и улучшению клинической симптоматики мастопатии.
Заключение. 7-HMR, снижая уровни эстрогеновых метаболитов у пациенток с ФКМ, способствует снижению опухолевых рисков, связанных с гиперэстрогенией.
Ключевые слова: диффузная кистозная мастопатия, климактерический синдром, метаболиты эстрогенов, 7-HMR
Aim. Assessment of effects 7-HMR on metabolism of estrogen (16a-OHE1, 2-OHE2, 2-OHE1, 2-OMEE1, 4-OMEE2, 4-OHE1, a ratio 2-OHE1/16a-OHE1, 2-OHE1/2-OMeE1 and 4-OHE1/4-OMeE1) and progesterone in daily urine at patients with fibrous and cystous mastopathy in the post-menopausal period.
Materials and methods. The analysis of metabolites of estrogen (16a-OHE1, 2-OHE2, 2-OHE1, 2-OMEE1, 4-OMEE2, 4-OHE1, ratios 2-OHE1/16a-OHE1, 2-OHE1/2-OMeE1 and 4-OHE1/4-OMeE1) and progesterone in daily urine with use of solid-phase immunofermental set (IFA) of "Amerscham International" on the analyzer of Amerkard by means of standard sets is carried out. Statistical 10.0 and Microsoft Excel spreadsheets were used in statistical material processing.
Results. It was found that taking 7-HMR (60 mg/day, 1 month) contributes to normalizing estrogen metabolism (decreasing estradiol, estrone, estriol, 16a-OHE1) and improves the clinical symptoms of mastopathy.
Conclusions. In patients with FCM, 7-HMR contributes to a decrease in hyperestrogenia-related tumor risks by lowering estrogen metabolites levels.
Key words: diffuse cystic mastopathy, menopause, estrogen metabolites, 7-HMR.
Цель. Оценка эффектов 7-HMR на метаболизм эстрогенов и прогестерона в суточной моче у пациенток с ФКМ в постменопаузальном периоде.
Материалы и методы. Проведен анализ метаболитов эстрогена (16a-ОНЕ1, 2-ОНЕ2, 2-ОНЕ1, 2-ОМеЕ1, 4-ОМеЕ2, 4-ОНЕ1, соотношения 2-ОНЕ1/16a-ОНЕ1,
2-ОНЕ1/2-OMeE1 и 4-OHE1/4-OMeE1) и прогестерона с использованием твердофазного иммуноферментного анализа.
Результаты. Установлено, что прием 7-HMR (60 мг/сут, 1 мес) способствует нормализации метаболизма эстрогенов (снижение эстрадиола, эстрона, эстриола, 16a-ОНЕ1) и улучшению клинической симптоматики мастопатии.
Заключение. 7-HMR, снижая уровни эстрогеновых метаболитов у пациенток с ФКМ, способствует снижению опухолевых рисков, связанных с гиперэстрогенией.
Ключевые слова: диффузная кистозная мастопатия, климактерический синдром, метаболиты эстрогенов, 7-HMR
________________________________________________
Aim. Assessment of effects 7-HMR on metabolism of estrogen (16a-OHE1, 2-OHE2, 2-OHE1, 2-OMEE1, 4-OMEE2, 4-OHE1, a ratio 2-OHE1/16a-OHE1, 2-OHE1/2-OMeE1 and 4-OHE1/4-OMeE1) and progesterone in daily urine at patients with fibrous and cystous mastopathy in the post-menopausal period.
Materials and methods. The analysis of metabolites of estrogen (16a-OHE1, 2-OHE2, 2-OHE1, 2-OMEE1, 4-OMEE2, 4-OHE1, ratios 2-OHE1/16a-OHE1, 2-OHE1/2-OMeE1 and 4-OHE1/4-OMeE1) and progesterone in daily urine with use of solid-phase immunofermental set (IFA) of "Amerscham International" on the analyzer of Amerkard by means of standard sets is carried out. Statistical 10.0 and Microsoft Excel spreadsheets were used in statistical material processing.
Results. It was found that taking 7-HMR (60 mg/day, 1 month) contributes to normalizing estrogen metabolism (decreasing estradiol, estrone, estriol, 16a-OHE1) and improves the clinical symptoms of mastopathy.
Conclusions. In patients with FCM, 7-HMR contributes to a decrease in hyperestrogenia-related tumor risks by lowering estrogen metabolites levels.
Key words: diffuse cystic mastopathy, menopause, estrogen metabolites, 7-HMR.
Полный текст
Список литературы
1. Hovelstad H, Leirset I, Oyaas K, Fiksdahl A. Screening analyses of pinosylvin stilbenes, resin acids and lignans in Norwegian conifers. Molecules. 2006; 11 (1): 103–14. DOI: 10.3390/11010103
2. Yamauchi S, Sugahara T, Nakashima Y et al. Radical and superoxide scavenging activities of matairesinol and oxidized matairesinol. Biosci Biotechnol Biochem 2006; 70 (8): 1934–40. DOI: 10.1271/bbb.60096
3. Smeds AI, Eklund PC, Willfor SM. Chemical characterization of high-molar-mass fractions in a Norway spruce knotwood ethanol extract. Phytochemistry 2016; 130: 207–17. DOI: 10.1016/j.phytochem.2016.05.006
4. Gerstenmeyer E, Reimer S, Berghofer E et al. Effect of thermal heating on some lignans in flax seeds, sesame seeds and rye. Food Chem 2013; 138 (2–3): 1847–55. DOI: 10.1016/j.foodchem.2012.11.117
5. Громова О.А., Торшин И.Ю., Рубашкина А.Н. и др. Систематический анализ фундаментальных и клинических исследований лигнана 7-гидроксиматаирезинола. Эффективная фармакотерапия. 2019; 15(13): 34–41. DOI 10.33978/2307-3586-2019-15-13-34-41
[Gromova O.A., Torshin I.Iu., Rubashkina A.N. et al. Sistematicheskii analiz fundamental'nykh i klinicheskikh issledovanii lignana 7-gidroksimatairezinola. Effektivnaia farmakoterapiia. 2019; 15(13): 34–41. DOI 10.33978/2307-3586-2019-15-13-34-41 (in Russian).]
6. Громова О.А., Рубашкина А.Н., Филимонова М.В. и др. Адъювантная терапия лигнаном 7-гидроксиматаирезинолом как метод повышения онкологической безопасности приема эстрогенов. Эффективная фармакотерапия. 2018; 13: 14–9.
[Gromova O.A., Rubashkina A.N., Filimonova M.V. et al. Ad"iuvantnaia terapiia lignanom 7-gidroksimatairezinolom kak metod povysheniia onkologicheskoi bezopasnosti priema estrogenov. Effektivnaia farmakoterapiia. 2018; 13: 14–9 (in Russian).]
7. Статистика злокачественных новообразований в России и странах СНГ в 2012 г. Под ред. М.И. Давыдова, Е.М. Аксель. М., 2014.
[Statistics of malignant tumors in Russia and CIS countries in 2012. Ed. by М.I. Davydov, Е.М. Аxel. Мoscow, 2014 (in Russian).]
8. Адамян Л.В., Андреева Е.Н., Артымук Н.В. и др. Доброкачественная дисплазия молочной железы. Клинические рекомендации (протокол), утв. МЗ РФ 07 ноября 2018 № 15-4/10/2-7235. М., 2018.
[Adamyan L.V., Andreeva E.N., Artymuk N.V. et al. Benign breast dysplasia. Clinical recommendations (protocol), approved. Ministry of Health of the Russian Federation on November 07, 2018 No. 15-4/10/2-7235. Мoscow, 2018 (in Russian).]
9. Каприн А.Д., Рожкова Н.И. Мастопатии. М.: ГЭОТАР-Медиа, 2019. (in Russian).]
[Kaprin A.D., Rozhkova N.I. Mastopathy. Мoscow: GEOTAR-Media, 2019 (in Russian).]
10. Torshin IYu. Optimal Dictionaries output information based on the criterion of Solvability and their applications in Bioinformatics. Pattern Recognition and Image Analysis 2013; 23 (2): 319–27.
11. Torshin IYu, Rudakov KV. On metric spaces arising during formalization of problems of recognition and classification. Part 2: Density properties. Pattern Recognition and Image Analysis (Advances in Mathematical Theory and Applications). 2016; 26 (3): 483–96.
12. Torshin IYu, Rudakov KV. Combinatorial analysis of the solvability properties of the problems of recognition and completeness of algorithmic models. Part 2: Metric approach within the framework of the theory of classification of feature values. Pattern Recognition and Image Analysis (Advances in Mathematical Theory and Applications). 2017; 27 (2): 184–99.
13. Swaneck GE, Fishman J. Covalent binding of the endogenous estrogen 16 alрfahydroxyesterone to estradiol receptor in human breast cancer cells: characterization and intranuclear localization. Proc Natl Acad Sci USA 1998; 85: 7831–35.
14. Киселев В.И., Ляшенко А.А. Молекулярные механизмы регуляции гиперпластических процессов. М.: Димитрейд График Групп, 2005.
[Kiselev V.I., Lyashenko А.А. Molecular mechanisms of the regulation of hyperplastic processes. Мoscow: Dimitreid Grafik Grupp, 2005 (in Russian).]
15. Сlemons M, Goss P. Estrogen and risk of breast cancer. N Engl J Med 2001; 344 (4): 276–85.
16. Segars JH, Driggers PH. Estrogen action and cytoplasmic signaling cascades. Part I: MEmbrane-associated signaling complexes. TRENDS Endocrinol Metab 2002; 13 (8): 349–54.
17. Zou JX, Revenko AS, Li LB et al. ANCCA, an estrogen-regulated AAA+ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification. Proc Natl Acad Sci USA 2007; 104 (46): 18067–72. DOI: 10.1073/pnas.0705814104
18. Zhang D, Jiang P, Xu Q, Zhang X. Arginine and glutamate-rich 1 (ARGLU1) interacts with mediator subunit 1 (MED1) and is required for estrogen receptor-mediated gene transcription and breast cancer cell growth. J Biol Chem 2011; 286 (20): 17746–54. DOI: 10.1074/jbc.M110.206029
19. Dhananjayan SC, Ramamoorthy S, Khan OY et al. WW domain binding protein-2, an E6-associated protein interacting protein, acts as a coactivator of estrogen and progesterone receptors. Mol Endocrinol 2006; 20 (10): 2343–54. DOI: 10.1210/me.2005-0533
20. Britschgi A, Duss S, Kim S et al. The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERalpha. Nature 2017; 541 (7638): 541–5. DOI: 10.1038/nature20829
21. Lee YF, Young WJ, Lin WJ et al. Differential regulation of direct repeat 3 vitamin D3 and direct repeat 4 thyroid hormone signaling pathways by the human TR4 orphan receptor. J Biol Chem 1999; 274 (23): 16198–205. DOI: 10.1074/jbc.274.23.16198
22. Van Agthoven T, van Agthoven TL, Dekker A et al. Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells. EMBO J 1998; 17 (10): 2799–808. DOI: 10.1093/emboj/17.10.2799
2. Yamauchi S, Sugahara T, Nakashima Y et al. Radical and superoxide scavenging activities of matairesinol and oxidized matairesinol. Biosci Biotechnol Biochem 2006; 70 (8): 1934–40. DOI: 10.1271/bbb.60096
3. Smeds AI, Eklund PC, Willfor SM. Chemical characterization of high-molar-mass fractions in a Norway spruce knotwood ethanol extract. Phytochemistry 2016; 130: 207–17. DOI: 10.1016/j.phytochem.2016.05.006
4. Gerstenmeyer E, Reimer S, Berghofer E et al. Effect of thermal heating on some lignans in flax seeds, sesame seeds and rye. Food Chem 2013; 138 (2–3): 1847–55. DOI: 10.1016/j.foodchem.2012.11.117
5. Gromova O.A., Torshin I.Iu., Rubashkina A.N. et al. Sistematicheskii analiz fundamental'nykh i klinicheskikh issledovanii lignana 7-gidroksimatairezinola. Effektivnaia farmakoterapiia. 2019; 15(13): 34–41. DOI 10.33978/2307-3586-2019-15-13-34-41 (in Russian).
6. Gromova O.A., Rubashkina A.N., Filimonova M.V. et al. Ad"iuvantnaia terapiia lignanom 7-gidroksimatairezinolom kak metod povysheniia onkologicheskoi bezopasnosti priema estrogenov. Effektivnaia farmakoterapiia. 2018; 13: 14–9 (in Russian).
7. Statistics of malignant tumors in Russia and CIS countries in 2012. Ed. by М.I. Davydov, Е.М. Аxel. Мoscow, 2014 (in Russian).
8. Adamyan L.V., Andreeva E.N., Artymuk N.V. et al. Benign breast dysplasia. Clinical recommendations (protocol), approved. Ministry of Health of the Russian Federation on November 07, 2018 No. 15-4/10/2-7235. Мoscow, 2018 (in Russian).
9. Kaprin A.D., Rozhkova N.I. Mastopathy. Мoscow: GEOTAR-Media, 2019 (in Russian).
10. Torshin IYu. Optimal Dictionaries output information based on the criterion of Solvability and their applications in Bioinformatics. Pattern Recognition and Image Analysis 2013; 23 (2): 319–27.
11. Torshin IYu, Rudakov KV. On metric spaces arising during formalization of problems of recognition and classification. Part 2: Density properties. Pattern Recognition and Image Analysis (Advances in Mathematical Theory and Applications). 2016; 26 (3): 483–96.
12. Torshin IYu, Rudakov KV. Combinatorial analysis of the solvability properties of the problems of recognition and completeness of algorithmic models. Part 2: Metric approach within the framework of the theory of classification of feature values. Pattern Recognition and Image Analysis (Advances in Mathematical Theory and Applications). 2017; 27 (2): 184–99.
13. Swaneck GE, Fishman J. Covalent binding of the endogenous estrogen 16 alрfahydroxyesterone to estradiol receptor in human breast cancer cells: characterization and intranuclear localization. Proc Natl Acad Sci USA 1998; 85: 7831–35.
14. Kiselev V.I., Lyashenko А.А. Molecular mechanisms of the regulation of hyperplastic processes. Мoscow: Dimitreid Grafik Grupp, 2005 (in Russian).
15. Сlemons M, Goss P. Estrogen and risk of breast cancer. N Engl J Med 2001; 344 (4): 276–85.
16. Segars JH, Driggers PH. Estrogen action and cytoplasmic signaling cascades. Part I: MEmbrane-associated signaling complexes. TRENDS Endocrinol Metab 2002; 13 (8): 349–54.
17. Zou JX, Revenko AS, Li LB et al. ANCCA, an estrogen-regulated AAA+ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification. Proc Natl Acad Sci USA 2007; 104 (46): 18067–72. DOI: 10.1073/pnas.0705814104
18. Zhang D, Jiang P, Xu Q, Zhang X. Arginine and glutamate-rich 1 (ARGLU1) interacts with mediator subunit 1 (MED1) and is required for estrogen receptor-mediated gene transcription and breast cancer cell growth. J Biol Chem 2011; 286 (20): 17746–54. DOI: 10.1074/jbc.M110.206029
19. Dhananjayan SC, Ramamoorthy S, Khan OY et al. WW domain binding protein-2, an E6-associated protein interacting protein, acts as a coactivator of estrogen and progesterone receptors. Mol Endocrinol 2006; 20 (10): 2343–54. DOI: 10.1210/me.2005-0533
20. Britschgi A, Duss S, Kim S et al. The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERalpha. Nature 2017; 541 (7638): 541–5. DOI: 10.1038/nature20829
21. Lee YF, Young WJ, Lin WJ et al. Differential regulation of direct repeat 3 vitamin D3 and direct repeat 4 thyroid hormone signaling pathways by the human TR4 orphan receptor. J Biol Chem 1999; 274 (23): 16198–205. DOI: 10.1074/jbc.274.23.16198
22. Van Agthoven T, van Agthoven TL, Dekker A et al. Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells. EMBO J 1998; 17 (10): 2799–808. DOI: 10.1093/emboj/17.10.2799
2. Yamauchi S, Sugahara T, Nakashima Y et al. Radical and superoxide scavenging activities of matairesinol and oxidized matairesinol. Biosci Biotechnol Biochem 2006; 70 (8): 1934–40. DOI: 10.1271/bbb.60096
3. Smeds AI, Eklund PC, Willfor SM. Chemical characterization of high-molar-mass fractions in a Norway spruce knotwood ethanol extract. Phytochemistry 2016; 130: 207–17. DOI: 10.1016/j.phytochem.2016.05.006
4. Gerstenmeyer E, Reimer S, Berghofer E et al. Effect of thermal heating on some lignans in flax seeds, sesame seeds and rye. Food Chem 2013; 138 (2–3): 1847–55. DOI: 10.1016/j.foodchem.2012.11.117
5. Громова О.А., Торшин И.Ю., Рубашкина А.Н. и др. Систематический анализ фундаментальных и клинических исследований лигнана 7-гидроксиматаирезинола. Эффективная фармакотерапия. 2019; 15(13): 34–41. DOI 10.33978/2307-3586-2019-15-13-34-41
[Gromova O.A., Torshin I.Iu., Rubashkina A.N. et al. Sistematicheskii analiz fundamental'nykh i klinicheskikh issledovanii lignana 7-gidroksimatairezinola. Effektivnaia farmakoterapiia. 2019; 15(13): 34–41. DOI 10.33978/2307-3586-2019-15-13-34-41 (in Russian).]
6. Громова О.А., Рубашкина А.Н., Филимонова М.В. и др. Адъювантная терапия лигнаном 7-гидроксиматаирезинолом как метод повышения онкологической безопасности приема эстрогенов. Эффективная фармакотерапия. 2018; 13: 14–9.
[Gromova O.A., Rubashkina A.N., Filimonova M.V. et al. Ad"iuvantnaia terapiia lignanom 7-gidroksimatairezinolom kak metod povysheniia onkologicheskoi bezopasnosti priema estrogenov. Effektivnaia farmakoterapiia. 2018; 13: 14–9 (in Russian).]
7. Статистика злокачественных новообразований в России и странах СНГ в 2012 г. Под ред. М.И. Давыдова, Е.М. Аксель. М., 2014.
[Statistics of malignant tumors in Russia and CIS countries in 2012. Ed. by М.I. Davydov, Е.М. Аxel. Мoscow, 2014 (in Russian).]
8. Адамян Л.В., Андреева Е.Н., Артымук Н.В. и др. Доброкачественная дисплазия молочной железы. Клинические рекомендации (протокол), утв. МЗ РФ 07 ноября 2018 № 15-4/10/2-7235. М., 2018.
[Adamyan L.V., Andreeva E.N., Artymuk N.V. et al. Benign breast dysplasia. Clinical recommendations (protocol), approved. Ministry of Health of the Russian Federation on November 07, 2018 No. 15-4/10/2-7235. Мoscow, 2018 (in Russian).]
9. Каприн А.Д., Рожкова Н.И. Мастопатии. М.: ГЭОТАР-Медиа, 2019. (in Russian).]
[Kaprin A.D., Rozhkova N.I. Mastopathy. Мoscow: GEOTAR-Media, 2019 (in Russian).]
10. Torshin IYu. Optimal Dictionaries output information based on the criterion of Solvability and their applications in Bioinformatics. Pattern Recognition and Image Analysis 2013; 23 (2): 319–27.
11. Torshin IYu, Rudakov KV. On metric spaces arising during formalization of problems of recognition and classification. Part 2: Density properties. Pattern Recognition and Image Analysis (Advances in Mathematical Theory and Applications). 2016; 26 (3): 483–96.
12. Torshin IYu, Rudakov KV. Combinatorial analysis of the solvability properties of the problems of recognition and completeness of algorithmic models. Part 2: Metric approach within the framework of the theory of classification of feature values. Pattern Recognition and Image Analysis (Advances in Mathematical Theory and Applications). 2017; 27 (2): 184–99.
13. Swaneck GE, Fishman J. Covalent binding of the endogenous estrogen 16 alрfahydroxyesterone to estradiol receptor in human breast cancer cells: characterization and intranuclear localization. Proc Natl Acad Sci USA 1998; 85: 7831–35.
14. Киселев В.И., Ляшенко А.А. Молекулярные механизмы регуляции гиперпластических процессов. М.: Димитрейд График Групп, 2005.
[Kiselev V.I., Lyashenko А.А. Molecular mechanisms of the regulation of hyperplastic processes. Мoscow: Dimitreid Grafik Grupp, 2005 (in Russian).]
15. Сlemons M, Goss P. Estrogen and risk of breast cancer. N Engl J Med 2001; 344 (4): 276–85.
16. Segars JH, Driggers PH. Estrogen action and cytoplasmic signaling cascades. Part I: MEmbrane-associated signaling complexes. TRENDS Endocrinol Metab 2002; 13 (8): 349–54.
17. Zou JX, Revenko AS, Li LB et al. ANCCA, an estrogen-regulated AAA+ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification. Proc Natl Acad Sci USA 2007; 104 (46): 18067–72. DOI: 10.1073/pnas.0705814104
18. Zhang D, Jiang P, Xu Q, Zhang X. Arginine and glutamate-rich 1 (ARGLU1) interacts with mediator subunit 1 (MED1) and is required for estrogen receptor-mediated gene transcription and breast cancer cell growth. J Biol Chem 2011; 286 (20): 17746–54. DOI: 10.1074/jbc.M110.206029
19. Dhananjayan SC, Ramamoorthy S, Khan OY et al. WW domain binding protein-2, an E6-associated protein interacting protein, acts as a coactivator of estrogen and progesterone receptors. Mol Endocrinol 2006; 20 (10): 2343–54. DOI: 10.1210/me.2005-0533
20. Britschgi A, Duss S, Kim S et al. The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERalpha. Nature 2017; 541 (7638): 541–5. DOI: 10.1038/nature20829
21. Lee YF, Young WJ, Lin WJ et al. Differential regulation of direct repeat 3 vitamin D3 and direct repeat 4 thyroid hormone signaling pathways by the human TR4 orphan receptor. J Biol Chem 1999; 274 (23): 16198–205. DOI: 10.1074/jbc.274.23.16198
22. Van Agthoven T, van Agthoven TL, Dekker A et al. Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells. EMBO J 1998; 17 (10): 2799–808. DOI: 10.1093/emboj/17.10.2799
________________________________________________
2. Yamauchi S, Sugahara T, Nakashima Y et al. Radical and superoxide scavenging activities of matairesinol and oxidized matairesinol. Biosci Biotechnol Biochem 2006; 70 (8): 1934–40. DOI: 10.1271/bbb.60096
3. Smeds AI, Eklund PC, Willfor SM. Chemical characterization of high-molar-mass fractions in a Norway spruce knotwood ethanol extract. Phytochemistry 2016; 130: 207–17. DOI: 10.1016/j.phytochem.2016.05.006
4. Gerstenmeyer E, Reimer S, Berghofer E et al. Effect of thermal heating on some lignans in flax seeds, sesame seeds and rye. Food Chem 2013; 138 (2–3): 1847–55. DOI: 10.1016/j.foodchem.2012.11.117
5. Gromova O.A., Torshin I.Iu., Rubashkina A.N. et al. Sistematicheskii analiz fundamental'nykh i klinicheskikh issledovanii lignana 7-gidroksimatairezinola. Effektivnaia farmakoterapiia. 2019; 15(13): 34–41. DOI 10.33978/2307-3586-2019-15-13-34-41 (in Russian).
6. Gromova O.A., Rubashkina A.N., Filimonova M.V. et al. Ad"iuvantnaia terapiia lignanom 7-gidroksimatairezinolom kak metod povysheniia onkologicheskoi bezopasnosti priema estrogenov. Effektivnaia farmakoterapiia. 2018; 13: 14–9 (in Russian).
7. Statistics of malignant tumors in Russia and CIS countries in 2012. Ed. by М.I. Davydov, Е.М. Аxel. Мoscow, 2014 (in Russian).
8. Adamyan L.V., Andreeva E.N., Artymuk N.V. et al. Benign breast dysplasia. Clinical recommendations (protocol), approved. Ministry of Health of the Russian Federation on November 07, 2018 No. 15-4/10/2-7235. Мoscow, 2018 (in Russian).
9. Kaprin A.D., Rozhkova N.I. Mastopathy. Мoscow: GEOTAR-Media, 2019 (in Russian).
10. Torshin IYu. Optimal Dictionaries output information based on the criterion of Solvability and their applications in Bioinformatics. Pattern Recognition and Image Analysis 2013; 23 (2): 319–27.
11. Torshin IYu, Rudakov KV. On metric spaces arising during formalization of problems of recognition and classification. Part 2: Density properties. Pattern Recognition and Image Analysis (Advances in Mathematical Theory and Applications). 2016; 26 (3): 483–96.
12. Torshin IYu, Rudakov KV. Combinatorial analysis of the solvability properties of the problems of recognition and completeness of algorithmic models. Part 2: Metric approach within the framework of the theory of classification of feature values. Pattern Recognition and Image Analysis (Advances in Mathematical Theory and Applications). 2017; 27 (2): 184–99.
13. Swaneck GE, Fishman J. Covalent binding of the endogenous estrogen 16 alрfahydroxyesterone to estradiol receptor in human breast cancer cells: characterization and intranuclear localization. Proc Natl Acad Sci USA 1998; 85: 7831–35.
14. Kiselev V.I., Lyashenko А.А. Molecular mechanisms of the regulation of hyperplastic processes. Мoscow: Dimitreid Grafik Grupp, 2005 (in Russian).
15. Сlemons M, Goss P. Estrogen and risk of breast cancer. N Engl J Med 2001; 344 (4): 276–85.
16. Segars JH, Driggers PH. Estrogen action and cytoplasmic signaling cascades. Part I: MEmbrane-associated signaling complexes. TRENDS Endocrinol Metab 2002; 13 (8): 349–54.
17. Zou JX, Revenko AS, Li LB et al. ANCCA, an estrogen-regulated AAA+ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification. Proc Natl Acad Sci USA 2007; 104 (46): 18067–72. DOI: 10.1073/pnas.0705814104
18. Zhang D, Jiang P, Xu Q, Zhang X. Arginine and glutamate-rich 1 (ARGLU1) interacts with mediator subunit 1 (MED1) and is required for estrogen receptor-mediated gene transcription and breast cancer cell growth. J Biol Chem 2011; 286 (20): 17746–54. DOI: 10.1074/jbc.M110.206029
19. Dhananjayan SC, Ramamoorthy S, Khan OY et al. WW domain binding protein-2, an E6-associated protein interacting protein, acts as a coactivator of estrogen and progesterone receptors. Mol Endocrinol 2006; 20 (10): 2343–54. DOI: 10.1210/me.2005-0533
20. Britschgi A, Duss S, Kim S et al. The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERalpha. Nature 2017; 541 (7638): 541–5. DOI: 10.1038/nature20829
21. Lee YF, Young WJ, Lin WJ et al. Differential regulation of direct repeat 3 vitamin D3 and direct repeat 4 thyroid hormone signaling pathways by the human TR4 orphan receptor. J Biol Chem 1999; 274 (23): 16198–205. DOI: 10.1074/jbc.274.23.16198
22. Van Agthoven T, van Agthoven TL, Dekker A et al. Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells. EMBO J 1998; 17 (10): 2799–808. DOI: 10.1093/emboj/17.10.2799
Авторы
А.Н. Рубашкина*1, Н.П. Лапочкина1, И.Ю. Торшин2, О.А. Громова2,3
1 ФГБОУ ВО «Ивановская государственная медицинская академия» Минздрава России, Иваново, Россия;
2 Федеральный исследовательский центр «Информатика и управление» Российской академии наук, Москва, Россия;
3 ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова», Москва, Россия
*Zima_1990@mail.ru
1 Ivanovo State Medical Academy, Ivanovo, Russia;
2 Federal Research Center "Informatics and Management", Moscow, Russia;
3 Lomonosov Moscow State University, Moscow, Russia
*Zima_1990@mail.ru
1 ФГБОУ ВО «Ивановская государственная медицинская академия» Минздрава России, Иваново, Россия;
2 Федеральный исследовательский центр «Информатика и управление» Российской академии наук, Москва, Россия;
3 ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова», Москва, Россия
*Zima_1990@mail.ru
________________________________________________
1 Ivanovo State Medical Academy, Ivanovo, Russia;
2 Federal Research Center "Informatics and Management", Moscow, Russia;
3 Lomonosov Moscow State University, Moscow, Russia
*Zima_1990@mail.ru
Цель портала OmniDoctor – предоставление профессиональной информации врачам, провизорам и фармацевтам.