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Оптимизация обеспеченности микронутриентами кормящих женщин и новорожденных на исключительно грудном вскармливании посредством обогащения рациона женщины
Оптимизация обеспеченности микронутриентами кормящих женщин и новорожденных на исключительно грудном вскармливании посредством обогащения рациона женщины
Коденцова В.М., Рисник Д.В., Павлович С.В., Ладодо О.Б. Оптимизация обеспеченности микронутриентами кормящих женщин и новорожденных на исключительно грудном вскармливании посредством обогащения рациона женщины. Гинекология. 2021; 23 (3): 222–230. DOI: 10.26442/20795696.2021.3.200875
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Аннотация
У значительной части беременных и кормящих женщин имеется недостаток одновременно нескольких микронутриентов (витамин D, группа В, йод, железо и др.). Секреция витаминов А, Е, D, C, В1, В2, В6, В12, йода и селена в грудное молоко снижается при их недостаточном потреблении и недостаточной обеспеченности ими кормящей матери. Содержание фолатов, кальция, магния, фосфора в грудном молоке поддерживается даже при их недостаточности у матери, однако обогащение ими рациона во время кормления грудью, улучшая статус матери, предотвращает истощение запасов в ее организме. Содержание железа и цинка в грудном молоке определяется статусом матери, сформировавшимся во время беременности. Прием витаминно-минеральных комплексов или обогащенных микронутриентами пищевых продуктов в прегравидарный период, в течение беременности и лактации приводит к улучшению обеспеченности женщины и ее ребенка за счет повышения содержания витаминов, йода и селена в грудном молоке. Использование витаминно-минеральных комплексов является эффективным способом не только устранения множественного дефицита микронутриентов в рационе и улучшения статуса кормящей женщины, но и оптимизации витаминного состава грудного молока и обеспеченности ребенка на исключительно естественном вскармливании.
Ключевые слова: витамины, макроэлементы, микроэлементы, кормящие женщины, грудное молоко, витаминно-минеральный статус ребенка, витаминно-минеральные комплексы, обогащенные пищевые продукты
Keywords: vitamins, macronutrients, microelements, lactating women, breast milk, vitamin and mineral status of a child, vitamin-mineral supplements, fortified foods
Ключевые слова: витамины, макроэлементы, микроэлементы, кормящие женщины, грудное молоко, витаминно-минеральный статус ребенка, витаминно-минеральные комплексы, обогащенные пищевые продукты
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Keywords: vitamins, macronutrients, microelements, lactating women, breast milk, vitamin and mineral status of a child, vitamin-mineral supplements, fortified foods
Полный текст
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2. Kodentsova VM, Risnik DV. Micronutrient metabolic networks and multiple micronutrient deficiency: a rationale for the advantages of vitamin-mineral supplements. Mikroelementy v meditsine. 2020;21(4):3-20 (in Russian) DOI:10.19112/2413-6174-2020-21-4-3-20
3. Ooylan LM, Hart S, Porter KB, Driskell JA. Vitamin B-6 content of breast milk and neonatal behavioral functioning. J Am Diet Assoc. 2002;102(10):1433-8.
DOI:10.1016/s0002-8223(02)90317-2
4. Torsvik IK, Ueland PM, Markestad T, et al. Motor development related to duration of exclusive breastfeeding, B vitamin status and B12 supplementation in infants with a birth weight between 2000–3000 g, results from a randomized intervention trial. BMC Pediatr. 2015;15:218. DOI:10.1186/s12887-015-0533-2
5. Honzik T, Adamovicova M, Smolka V, et al. Clinical presentation and metabolic consequences in 40 breastfed infants with nutritional vitamin B12 deficiency – what have we learned? Eur J Paediatr Neurol. 2010;14(6):488-95. DOI:10.1016/j.ejpn.2009.12.003
6. Munns CF, Shaw N, Kiely M, et al. Global Consensus Recommendations on Prevention and Management of Nutritional Rickets. J Clin Endocrinol Metab. 2016;101(2):394-415. DOI:10.1210/jc.2015-2175
7. Dror DK, Allen LH. Vitamin B-12 in Human Milk: A Systematic Review. Adv Nutr. 2018;9(Suppl. 1):358S-366S. DOI:10.1093/advances/nmx019
8. Swaminathan S, Thomas T, Kurpad AV. B-vitamin interventions for women and children in low-income populations. Curr Opin Clin Nutr Metab Care. 2015;18(3):295-306. DOI:10.1097/MCO.0000000000000166
9. Dror DK, Allen LH. Overview of Nutrients in Human Milk. Adv Nutr. 2018;9(Suppl. 1):278S-294S. DOI:10.1093/advances/nmy022
10. Grantham-McGregor SM, Ani C. A review of studies on the effect of iron deficiency on cognitive development in children. J Nutr. 2001;131(2S-2):649S-668S. DOI:10.1093/jn/131.2.649S
11. Chumbadze TR, Skvortsova VA, Borovik TE, et al. The influence of specialized products on the trace element composition of breast milk in breastfeeding women. Voprosy detskoi dietologii. 2008;6(5):55-8 (in Russian)
12. Beketova NA, Sokolnikov AA, Kodentsova VM, et al. The vitamin status of pregnant women in Moscow: effect of multivitamin-mineral supplements. Voprosy pitaniia. 2016;85(5):77-85 (in Russian)
13. Kodentsova VM, Beketova NA, Nikityuk DB, Tutelyan VA. Characteristics of vitamin provision in the adult population of the Russian Federation. Profilakticheskaia meditsina. 2018;21(4):32-7 (in Russian)]. DOI:10.17116/profmed201821432
14. Malyavskaya SI, Karamyan VG, Kostrova GN, Lebedev AV. The provision of vitamin D in parturients and newborn infants in the mother-child dyad under the conditions of the subarctic zone of the Russian Federation in the winter season. Akusherstvo i ginekologiya. 2018;3:58-62 (in Russian) DOI:10.18565/aig.2018.3.58-62
15. Zakharova IN, Klimov LYа, Kuryaninova VA, et al. Vitamin D provision for babies. Rossiyskiy vestnik perinatologii i pediatrii. 2016;61(6):68-76
(in Russian) DOI:10.21508/1027-4065-2016-61-6-68-76
16. Kurmacheva NA, Rogozhina IE, Chernenkov YuV, Panina OS. Efficacy of Elevit® Vitamin-Mineral Complex Pronatal from early pregnancy for improvement of obstetric and perinatal outcomes. Gynecology. 2018;20(4):19-25 (in Russian) DOI:10.26442/2079-5696_2018.4.19-25
17. Keikha M, Bahreynian M, Saleki M, Kelishadi R. Macro- and Micronutrients of Human Milk Composition: Are They Related to Maternal Diet? A Comprehensive Systematic Review. Breastfeed Med. 2017;12(9):517-27. DOI:10.1089/bfm.2017.0048
18. Allen LH. Maternal micronutrient malnutrition: effects on breast milk and infant nutrition, and priorities for intervention. SCN News. 1994;11:21-4.
19. Kodentsova VM, Vrzhesinskaya OA. Evaluation of the vitamin status in nursing women by vitamin content in breast milk. Biulleten' eksperimental'noi biologii i meditsiny. 2006;141(3):323-7 (in Russian) DOI:10.1007/s10517-006-0161-9
20. Machado MR, Kamp F, Nunes JC, et al. Breast Milk Content of Vitamin A and E from Early-to Mid-Lactation Is Affected by Inadequate Dietary Intake in Brazilian Adult Women. Nutrients. 2019;11(9):2025. DOI:10.3390/nu11092025
21. Dror DK, Allen LH. Retinol-to-Fat Ratio and Retinol Concentration in Human Milk Show Similar Time Trends and Associations with Maternal Factors at the Population Level: A Systematic Review and Meta-Analysis. Adv Nutr. 2018;9(Suppl. 1):332S-346S. DOI:10.1093/advances/nmy021
22. WHO. Indicators for assessing Vitamin A Deficiency and their application in monitoring and evaluating intervention programmes. Geneva: World Health Organization, 1996. Available at: https://www.who.int/nutrition/publications/micronutrients/vitamin_a_deficiency/WHONUT96.10.pdf?ua=1. Accessed: 16.11.2020.
23. West KP Jr. Extent of vitamin A deficiency among preschool children and women of reproductive age. J Nutr. 2002;132:2857S-2866S. DOI:10.1093/jn/132.9.2857S
24. Dawodu A, Tsang RC. Maternal vitamin D status: effect on milk vitamin D content and vitamin D status of breastfeeding infants. Adv Nutr. 2012;3(3):353-61. DOI:10.3945/an.111.000950
25. Samuel TM, Zhou Q, Giuffrida F, et al. Nutritional and Non-nutritional Composition of Human Milk Is Modulated by Maternal, Infant, and Methodological Factors. Front Nutr. 2020;7:576133. DOI:10.3389/fnut.2020.576133
26. Allen LH, Donohue JA, Dror DK. Limitations of the Evidence Base Used to Set Recommended Nutrient Intakes for Infants and Lactating Women. Adv Nutr. 2018;9(Suppl. 1):295S-312S. DOI:10.1093/advances/nmy019
27. Dror DK, Allen LH. Iodine in Human Milk: A Systematic Review. Adv Nutr. 2018;9(Suppl. 1):347S-357S. DOI:10.1093/advances/nmy020
28. Nazeri P, Dalili H, Mehrabi Y, et al. Breast Milk Iodine Concentration Rather than Maternal Urinary Iodine Is a Reliable Indicator for Monitoring Iodine Status of Breastfed Neonates. Biol Trace Elem Res. 2018;185(1):71-7. DOI:10.1007/s12011-018-1246-9
29. Troshina EA. Current aspects of prevention and treatment of iodine deficiency disorders. Focus on risk groups. Meditsinskiy sovet. 2016;3:82-5 (in Russian)
DOI:10.21518/2079-701X-2016-3-82-85
30. Public Health Committee of the American Thyroid Association; Becker DV, Braverman LE, Delange F, et al. Iodine supplementation for pregnancy and lactation-United States and Canada: recommendations of the American Thyroid Association. Thyroid. 2006;16(10):949-51. DOI:10.1089/thy.2006.16.949
31. Alexander EK, Pearce EN, Brent GA, et al. 2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum. Thyroid. 2017;27(3):315-89. DOI:10.1089/thy.2016.0457
32. Harding KB, Peña-Rosas JP, Webster AC, et al. Iodine supplementation for women during the preconception, pregnancy and postpartum period. Cochrane Database Syst Rev. 2017;3(3):CD011761.DOI:10.1002/14651858.CD011761.pub2
33. Agostoni C, Braegger C, Decsi T, et al. Breast-feeding: A commentary by the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr. 2009;49(1):112-25. DOI:10.1097/MPG.0b013e31819f1e05
34. Pérez-Escamilla R, Buccini GS, Segura-Pérez S, Piwoz E. Perspective: Should Exclusive Breastfeeding Still Be Recommended for 6 Months? Adv Nutr. 2019;10(6):931-43. DOI:10.1093/advances/nmz039
35. El-Farrash RA, Ismail EAR, Nada AS. Cord blood iron profile and breast milk micronutrients in maternal iron deficiency anemia. Pediatr Blood Cancer. 2012;58(2):233-8. DOI:10.1002/pbc.23184
36. Barkova EN, Nazarenko EV, Zhdanova EV. Diurnal variations in qualitative composition of breast milk in women with iron deficiency. Bull Exp Biol Med. 2005;140(4):394-6. DOI:10.1007/s10517-005-0500-2
37. Choi YK, Kim JM, Lee JE, et al. Association of Maternal Diet With Zinc, Copper, And Iron Concentrations in Transitional Human Milk Produced by Korean Mothers. Clin Nutr Res. 2016;5(1):15-25. DOI:10.7762/cnr.2016.5.1.15
38. Keikha M, Shayan-Moghadam R, Bahreynian M, Kelishadi R. Nutritional supplements and mother’s milk composition: a systematic review of interventional studies. Int Breastfeed J. 2021;16(1):1-30. DOI:10.1186/s13006-020-00354-0
39. Kodentsova VM, Vrzhesinskaya OA. The influence of the vitamin deficiency on the sufficiency of the organism with vitamin D. Voprosy biologicheskoi, meditsinskoi i farmatsevticheskoi khimii. 2018;21(7):42-6 (in Russian) DOI:10.29296/25877313-2018-07-07
40. Rosanoff A, Dai Q, Shapses SA. Essential Nutrient Interactions: Does Low or Suboptimal Magnesium Status Interact with Vitamin D and/or Calcium Status? Adv Nutr. 2016;7(1):25-43. DOI:10.3945/an.115.008631
41. Dai Q, Zhu X, Manson JE, et al. Magnesium status and supplementation influence vitamin D status and metabolism: results from a randomized trial. Am J Clin Nutr. 2018;108(6):1249-58. DOI:10.1093/ajcn/nqy27
42. Lukoyanova OL, Vrzhesinskaya OA, Kodentsova VM, et al. Zavisimost' vitaminnogo sostava grudnogo moloka zhenshchin ot priema polivitaminnykh preparatov v period beremennosti i laktatsii. Voprosy pitaniia. 1999;4:24-6 (in Russian)
43. Hampel D, Shahab-Ferdows S, Islam MM, et al. Vitamin Concentrations in Human Milk Vary with Time within Feed, Circadian Rhythm, and Single-Dose Supplementation. J Nutr. 2017;147(4):603-11. DOI:10.3945/jn.116.242941
44. Sánchez C, Fente C, Barreiro R, et al. Association between Breast Milk Mineral Content and Maternal Adherence to Healthy Dietary Patterns in Spain: A Transversal Study. Foods. 2020;9(5):659. DOI:10.3390/foods9050659
45. Vrzhesinskaya OA, Kodentsova VM, Pereverzeva OG, et al. Evaluation of sufficiency with vitamins C, B1 and B2 of newborn infants feeding different types of nutrition, by means of urinary excretion determination. Voprosy pitaniia. 2015;84(4):105-11 (in Russian)
46. Donohue JA, Solomons NW, Hampel D, et al. Micronutrient supplementation of lactating Guatemalan women acutely increases infants’ intake of riboflavin, thiamin, pyridoxal, and cobalamin, but not niacin, in a randomized crossover trial. Am J Clin Nutr. 2020;112(3):669-82. DOI:10.1093/ajcn/nqaa147
47. Daniels L, Gibson RS, Diana A, et al. Micronutrient intakes of lactating mothers and their association with breast milk concentrations and micronutrient adequacy of exclusively breastfed Indonesian infants. Am J Clin Nutr. 2019;110(2):391-400. DOI:10.1093/ajcn/nqz047
48. Mari GH, Mestorino N, Errecalde J, et al. Personalised iron supply for prophylaxis and treatment of pregnant women as a way to ensure normal iron levels in their breast milk. J Med Life. 2012;5(1):29-32.
49. Whitfield KC, Shahab-Ferdows S, Kroeun H, et al. Macro- and Micronutrients in Milk from Healthy Cambodian Mothers: Status and Interrelations. J Nutr. 2020;150(6):1461-9. DOI:10.1093/jn/nxaa070
50. Osei J, Andersson M, van der Reijden O, et al. Breast-Milk Iodine Concentrations, Iodine Status, and Thyroid Function of Breastfed Infants Aged 2–4 Months and Their Mothers Residing in a South African Township. J Clin Res Pediatr Endocrinol. 2016;8(4):381-91. DOI:10.4274/jcrpe.2720
51. Belykh NA, Korniyenko LI. Estimation of trace elements (iodine and iron) content in breast milk. Zdorov'e rebenka. 2013;5:53-7 (in Russian)
52. Nazeri P, Tahmasebinejad Z, Mehrabi Y, et al. Lactating Mothers and Infants Residing in an Area with an Effective Salt Iodization Program Have No Need for Iodine Supplements: Results from a Double-Blind, Placebo-Controlled, Randomized Controlled Trial. Thyroid. 2018;28(11):1547-58. DOI:10.1089/thy.2018.0153
53. Abe SK, Balogun OO, Ota E, et al. Supplementation with multiple micronutrients for breastfeeding women for improving outcomes for the mother and baby. Cochrane Database Syst Rev. 2016;2:CD010647. DOI:10.1002/14651858.CD010647.pub2
54. Kodentsova VM, Gmoshinskaya MV, Vrzhesinskaya OA. Vitamin-mineral supplements for pregnant and lactating women: justification of composition and doses. Reproduktivnoe zdorov'e detei i podrostkov. 2015;3:73-96 (in Russian)
55. Gromova OA, Torshin IIu, Kosheleva NG. Molekuliarnye sinergisty ioda: novye podkhody k effektivnoi profilaktike i terapii iod-defitsitnykh zabolevanii u beremennykh. RMZh. Mat' i ditia. 2011;19(1):51-8 (in Russian)
56. Gromova OA, Torshin IIu, Khadzhidis AK. Analiz molekuliarnykh mekhanizmov vozdeistviia zheleza (II), medi, margantsa v patogeneze zhelezodefitsitnoi anemii. Klinicheskaia farmakologiia i farmaekonomika. 2010;1:1-9 (in Russian)
57. Hampel D, Allen LH. Analyzing B-vitamins in Human Milk: Methodological Approaches. Crit Rev Food Sci Nutr. 2016;56(3):494-511. DOI:10.1080/10408398.2013.783550
58. Butskaya TV, Fisenko AP, Makarova SG, et al. Nutritional awareness of women of childbearing age during the breastfeeding period. Voprosy detskoi dietologii. 2020;18(2):23-30 (in Russian) DOI:10.20953/1727-57842020-2-23-30
59. Ladodo OB, Khukhreva DA, Moshkina NA, Murav'ev SM. Aktual'nye problemy grudnogo vskarmlivaniia. Meditsinskii opponent. 2020;4(12):18-23 (in Russian)
2. Коденцова В.М., Рисник Д.В. Микронутриентные метаболические сети и множественный дефицит микронутриентов: обоснование преимуществ витаминно-минеральных комплексов. Микроэлементы в медицине. 2020;21(4):3-20 [Kodentsova VM, Risnik DV. Micronutrient metabolic networks and multiple micronutrient deficiency: a rationale for the advantages of vitamin-mineral supplements. Mikroelementy v meditsine. 2020;21(4):3-20 (in Russian)]. DOI:10.19112/2413-6174-2020-21-4-3-20
3. Ooylan LM, Hart S, Porter KB, Driskell JA. Vitamin B-6 content of breast milk and neonatal behavioral functioning. J Am Diet Assoc. 2002;102(10):1433-8.
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4. Torsvik IK, Ueland PM, Markestad T, et al. Motor development related to duration of exclusive breastfeeding, B vitamin status and B12 supplementation in infants with a birth weight between 2000–3000 g, results from a randomized intervention trial. BMC Pediatr. 2015;15:218. DOI:10.1186/s12887-015-0533-2
5. Honzik T, Adamovicova M, Smolka V, et al. Clinical presentation and metabolic consequences in 40 breastfed infants with nutritional vitamin B12 deficiency – what have we learned? Eur J Paediatr Neurol. 2010;14(6):488-95. DOI:10.1016/j.ejpn.2009.12.003
6. Munns CF, Shaw N, Kiely M, et al. Global Consensus Recommendations on Prevention and Management of Nutritional Rickets. J Clin Endocrinol Metab. 2016;101(2):394-415. DOI:10.1210/jc.2015-2175
7. Dror DK, Allen LH. Vitamin B-12 in Human Milk: A Systematic Review. Adv Nutr. 2018;9(Suppl. 1):358S-366S. DOI:10.1093/advances/nmx019
8. Swaminathan S, Thomas T, Kurpad AV. B-vitamin interventions for women and children in low-income populations. Curr Opin Clin Nutr Metab Care. 2015;18(3):295-306. DOI:10.1097/MCO.0000000000000166
9. Dror DK, Allen LH. Overview of Nutrients in Human Milk. Adv Nutr. 2018;9(Suppl. 1):278S-294S. DOI:10.1093/advances/nmy022
10. Grantham-McGregor SM, Ani C. A review of studies on the effect of iron deficiency on cognitive development in children. J Nutr. 2001;131(2S-2):649S-668S. DOI:10.1093/jn/131.2.649S
11. Чумбадзе Т.Р., Скворцова В.А., Боровик Т.Э., и др. Влияние специализированных продуктов на микроэлементный состав грудного молока кормящих женщин. Вопросы детской диетологии. 2008;6(5):55-8 [Chumbadze TR, Skvortsova VA, Borovik TE, et al. The influence of specialized products on the trace element composition of breast milk in breastfeeding women. Voprosy detskoi dietologii. 2008;6(5):55-8 (in Russian)].
12. Бекетова Н.А., Сокольников А.А., Коденцова В.М., и др. Витаминный статус беременных женщин-москвичек: влияние приема витаминно-минеральных комплексов. Вопр. питания. 2016;85(5):77-85 [Beketova NA, Sokolnikov AA, Kodentsova VM, et al. The vitamin status of pregnant women in Moscow: effect of multivitamin-mineral supplements. Voprosy pitaniia. 2016;85(5):77-85 (in Russian)].
13. Коденцова В.М., Бекетова Н.А., Никитюк Д.Б., Тутельян В.А. Характеристика обеспеченности витаминами взрослого населения Российской Федерации. Профилактическая медицина. 2018;21(4):32-7 [Kodentsova VM, Beketova NA, Nikityuk DB, Tutelyan VA. Characteristics of vitamin provision in the adult population of the Russian Federation. Profilakticheskaia meditsina. 2018;21(4):32-7 (in Russian)]. DOI:10.17116/profmed201821432
14. Малявская С.И., Карамян В.Г., Кострова Г.Н., Лебедев А.В. Обеспеченность витамином D рожениц и новорожденных в диаде «мать-дитя» в условиях приарктической зоны РФ в зимний период. Акушерство и гинекология. 2018;3:58-62 [Malyavskaya SI, Karamyan VG, Kostrova GN, Lebedev AV. The provision of vitamin D in parturients and newborn infants in the mother-child dyad under the conditions of the subarctic zone of the Russian Federation in the winter season. Akusherstvo i ginekologiya. 2018;3:58-62 (in Russian)]. DOI:10.18565/aig.2018.3.58-62
15. Захарова И.Н., Климов Л.Я., Курьянинова В.А., и др. Обеспеченность витамином D детей грудного возраста. Российский вестник перинатологии и педиатрии. 2016;61(6):68-76 [Zakharova IN, Klimov LYа, Kuryaninova VA, et al. Vitamin D provision for babies. Rossiyskiy vestnik perinatologii i pediatrii. 2016;61(6):68-76
(in Russian)]. DOI:10.21508/1027-4065-2016-61-6-68-76
16. Курмачева Н.А., Рогожина И.Е., Черненков Ю.В., Панина О.С. Эффективность применения витаминно-минерального комплекса Элевит® Пронаталь с ранних сроков беременности с целью улучшения акушерских и перинатальных исходов. Гинекология. 2018;20(4):19-25 [Kurmacheva NA, Rogozhina IE, Chernenkov YuV, Panina OS. Efficacy of Elevit® Vitamin-Mineral Complex Pronatal from early pregnancy for improvement of obstetric and perinatal outcomes. Gynecology. 2018;20(4):19-25 (in Russian)].
DOI:10.26442/2079-5696_2018.4.19-25
17. Keikha M, Bahreynian M, Saleki M, Kelishadi R. Macro- and Micronutrients of Human Milk Composition: Are They Related to Maternal Diet? A Comprehensive Systematic Review. Breastfeed Med. 2017;12(9):517-27. DOI:10.1089/bfm.2017.0048
18. Allen LH. Maternal micronutrient malnutrition: effects on breast milk and infant nutrition, and priorities for intervention. SCN News. 1994;11:21-4.
19. Коденцова В.М., Вржесинская О.А. Оценка витаминного статуса кормящих женщин по содержанию витаминов в грудном молоке. Бюллетень экспериментальной биологии и медицины. 2006;141(3):323-7 [Kodentsova VM, Vrzhesinskaya OA. Evaluation of the vitamin status in nursing women by vitamin content in breast milk. Biulleten' eksperimental'noi biologii i meditsiny. 2006;141(3):323-7
(in Russian)]. DOI:10.1007/s10517-006-0161-9
20. Machado MR, Kamp F, Nunes JC, et al. Breast Milk Content of Vitamin A and E from Early-to Mid-Lactation Is Affected by Inadequate Dietary Intake in Brazilian Adult Women. Nutrients. 2019;11(9):2025. DOI:10.3390/nu11092025
21. Dror DK, Allen LH. Retinol-to-Fat Ratio and Retinol Concentration in Human Milk Show Similar Time Trends and Associations with Maternal Factors at the Population Level: A Systematic Review and Meta-Analysis. Adv Nutr. 2018;9(Suppl. 1):332S-346S. DOI:10.1093/advances/nmy021
22. WHO. Indicators for assessing Vitamin A Deficiency and their application in monitoring and evaluating intervention programmes. Geneva: World Health Organization, 1996. Available at: https://www.who.int/nutrition/publications/micronutrients/vitamin_a_deficiency/WHONUT96.10.pdf?ua=1. Accessed: 16.11.2020.
23. West KP Jr. Extent of vitamin A deficiency among preschool children and women of reproductive age. J Nutr. 2002;132:2857S-2866S. DOI:10.1093/jn/132.9.2857S
24. Dawodu A, Tsang RC. Maternal vitamin D status: effect on milk vitamin D content and vitamin D status of breastfeeding infants. Adv Nutr. 2012;3(3):353-61. DOI:10.3945/an.111.000950
25. Samuel TM, Zhou Q, Giuffrida F, et al. Nutritional and Non-nutritional Composition of Human Milk Is Modulated by Maternal, Infant, and Methodological Factors. Front Nutr. 2020;7:576133. DOI:10.3389/fnut.2020.576133
26. Allen LH, Donohue JA, Dror DK. Limitations of the Evidence Base Used to Set Recommended Nutrient Intakes for Infants and Lactating Women. Adv Nutr. 2018;9(Suppl. 1):295S-312S. DOI:10.1093/advances/nmy019
27. Dror DK, Allen LH. Iodine in Human Milk: A Systematic Review. Adv Nutr. 2018;9(Suppl. 1):347S-357S. DOI:10.1093/advances/nmy020
28. Nazeri P, Dalili H, Mehrabi Y, et al. Breast Milk Iodine Concentration Rather than Maternal Urinary Iodine Is a Reliable Indicator for Monitoring Iodine Status of Breastfed Neonates. Biol Trace Elem Res. 2018;185(1):71-7. DOI:10.1007/s12011-018-1246-9
29. Трошина Е.А. Современные аспекты профилактики и лечения йододефицитных заболеваний. Фокус на группы риска. Медицинский совет. 2016;3:82-5 [Troshina EA. Current aspects of prevention and treatment of iodine deficiency disorders. Focus on risk groups. Meditsinskiy sovet. 2016;3:82-5 (in Russian)].
DOI:10.21518/2079-701X-2016-3-82-85
30. Public Health Committee of the American Thyroid Association; Becker DV, Braverman LE, Delange F, et al. Iodine supplementation for pregnancy and lactation-United States and Canada: recommendations of the American Thyroid Association. Thyroid. 2006;16(10):949-51. DOI:10.1089/thy.2006.16.949
31. Alexander EK, Pearce EN, Brent GA, et al. 2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum. Thyroid. 2017;27(3):315-89. DOI:10.1089/thy.2016.0457
32. Harding KB, Peña-Rosas JP, Webster AC, et al. Iodine supplementation for women during the preconception, pregnancy and postpartum period. Cochrane Database Syst Rev. 2017;3(3):CD011761.DOI:10.1002/14651858.CD011761.pub2
33. Agostoni C, Braegger C, Decsi T, et al. Breast-feeding: A commentary by the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr. 2009;49(1):112-25. DOI:10.1097/MPG.0b013e31819f1e05
34. Pérez-Escamilla R, Buccini GS, Segura-Pérez S, Piwoz E. Perspective: Should Exclusive Breastfeeding Still Be Recommended for 6 Months? Adv Nutr. 2019;10(6):931-43. DOI:10.1093/advances/nmz039
35. El-Farrash RA, Ismail EAR, Nada AS. Cord blood iron profile and breast milk micronutrients in maternal iron deficiency anemia. Pediatr Blood Cancer. 2012;58(2):233-8. DOI:10.1002/pbc.23184
36. Barkova EN, Nazarenko EV, Zhdanova EV. Diurnal variations in qualitative composition of breast milk in women with iron deficiency. Bull Exp Biol Med. 2005;140(4):394-6. DOI:10.1007/s10517-005-0500-2
37. Choi YK, Kim JM, Lee JE, et al. Association of Maternal Diet With Zinc, Copper, And Iron Concentrations in Transitional Human Milk Produced by Korean Mothers. Clin Nutr Res. 2016;5(1):15-25. DOI:10.7762/cnr.2016.5.1.15
38. Keikha M, Shayan-Moghadam R, Bahreynian M, Kelishadi R. Nutritional supplements and mother’s milk composition: a systematic review of interventional studies. Int Breastfeed J. 2021;16(1):1-30. DOI:10.1186/s13006-020-00354-0
39. Коденцова В.М., Вржесинская О.А. Влияние дефицита витаминов на обеспеченность организма витамином D. Вопросы биологической, медицинской и фармацевтической химии. 2018;21(7):42-6 [Kodentsova VM, Vrzhesinskaya OA. The influence of the vitamin deficiency on the sufficiency of the organism with vitamin D. Voprosy biologicheskoi, meditsinskoi i farmatsevticheskoi khimii. 2018;21(7):42-6 (in Russian)]. DOI:10.29296/25877313-2018-07-07
40. Rosanoff A, Dai Q, Shapses SA. Essential Nutrient Interactions: Does Low or Suboptimal Magnesium Status Interact with Vitamin D and/or Calcium Status? Adv Nutr. 2016;7(1):25-43. DOI:10.3945/an.115.008631
41. Dai Q, Zhu X, Manson JE, et al. Magnesium status and supplementation influence vitamin D status and metabolism: results from a randomized trial. Am J Clin Nutr. 2018;108(6):1249-58. DOI:10.1093/ajcn/nqy27
42. Лукоянова О.Л., Вржесинская О.А., Коденцова В.М., и др. Зависимость витаминного состава грудного молока женщин от приема поливитаминных препаратов в период беременности и лактации. Вопр. питания. 1999;4:24-6 [Lukoyanova OL, Vrzhesinskaya OA, Kodentsova VM, et al. Zavisimost' vitaminnogo sostava grudnogo moloka zhenshchin ot priema polivitaminnykh preparatov v period beremennosti i laktatsii. Voprosy pitaniia. 1999;4:24-6 (in Russian)].
43. Hampel D, Shahab-Ferdows S, Islam MM, et al. Vitamin Concentrations in Human Milk Vary with Time within Feed, Circadian Rhythm, and Single-Dose Supplementation. J Nutr. 2017;147(4):603-11. DOI:10.3945/jn.116.242941
44. Sánchez C, Fente C, Barreiro R, et al. Association between Breast Milk Mineral Content and Maternal Adherence to Healthy Dietary Patterns in Spain: A Transversal Study. Foods. 2020;9(5):659. DOI:10.3390/foods9050659
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47. Daniels L, Gibson RS, Diana A, et al. Micronutrient intakes of lactating mothers and their association with breast milk concentrations and micronutrient adequacy of exclusively breastfed Indonesian infants. Am J Clin Nutr. 2019;110(2):391-400. DOI:10.1093/ajcn/nqz047
48. Mari GH, Mestorino N, Errecalde J, et al. Personalised iron supply for prophylaxis and treatment of pregnant women as a way to ensure normal iron levels in their breast milk. J Med Life. 2012;5(1):29-32.
49. Whitfield KC, Shahab-Ferdows S, Kroeun H, et al. Macro- and Micronutrients in Milk from Healthy Cambodian Mothers: Status and Interrelations. J Nutr. 2020;150(6):1461-9. DOI:10.1093/jn/nxaa070
50. Osei J, Andersson M, van der Reijden O, et al. Breast-Milk Iodine Concentrations, Iodine Status, and Thyroid Function of Breastfed Infants Aged 2–4 Months and Their Mothers Residing in a South African Township. J Clin Res Pediatr Endocrinol. 2016;8(4):381-91. DOI:10.4274/jcrpe.2720
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53. Abe SK, Balogun OO, Ota E, et al. Supplementation with multiple micronutrients for breastfeeding women for improving outcomes for the mother and baby. Cochrane Database Syst Rev. 2016;2:CD010647. DOI:10.1002/14651858.CD010647.pub2
54. Коденцова В.М., Гмошинская М.В., Вржесинская О.А. Витаминно-минеральные комплексы для беременных и кормящих женщин: обоснование состава и доз. Репродуктивное здоровье детей и подростков. 2015;3:73-96 [Kodentsova VM, Gmoshinskaya MV, Vrzhesinskaya OA. Vitamin-mineral supplements for pregnant and lactating women: justification of composition and doses. Reproduktivnoe zdorov'e detei i podrostkov. 2015;3:73-96 (in Russian)].
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31. Alexander EK, Pearce EN, Brent GA, et al. 2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum. Thyroid. 2017;27(3):315-89. DOI:10.1089/thy.2016.0457
32. Harding KB, Peña-Rosas JP, Webster AC, et al. Iodine supplementation for women during the preconception, pregnancy and postpartum period. Cochrane Database Syst Rev. 2017;3(3):CD011761.DOI:10.1002/14651858.CD011761.pub2
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37. Choi YK, Kim JM, Lee JE, et al. Association of Maternal Diet With Zinc, Copper, And Iron Concentrations in Transitional Human Milk Produced by Korean Mothers. Clin Nutr Res. 2016;5(1):15-25. DOI:10.7762/cnr.2016.5.1.15
38. Keikha M, Shayan-Moghadam R, Bahreynian M, Kelishadi R. Nutritional supplements and mother’s milk composition: a systematic review of interventional studies. Int Breastfeed J. 2021;16(1):1-30. DOI:10.1186/s13006-020-00354-0
39. Kodentsova VM, Vrzhesinskaya OA. The influence of the vitamin deficiency on the sufficiency of the organism with vitamin D. Voprosy biologicheskoi, meditsinskoi i farmatsevticheskoi khimii. 2018;21(7):42-6 (in Russian) DOI:10.29296/25877313-2018-07-07
40. Rosanoff A, Dai Q, Shapses SA. Essential Nutrient Interactions: Does Low or Suboptimal Magnesium Status Interact with Vitamin D and/or Calcium Status? Adv Nutr. 2016;7(1):25-43. DOI:10.3945/an.115.008631
41. Dai Q, Zhu X, Manson JE, et al. Magnesium status and supplementation influence vitamin D status and metabolism: results from a randomized trial. Am J Clin Nutr. 2018;108(6):1249-58. DOI:10.1093/ajcn/nqy27
42. Lukoyanova OL, Vrzhesinskaya OA, Kodentsova VM, et al. Zavisimost' vitaminnogo sostava grudnogo moloka zhenshchin ot priema polivitaminnykh preparatov v period beremennosti i laktatsii. Voprosy pitaniia. 1999;4:24-6 (in Russian)
43. Hampel D, Shahab-Ferdows S, Islam MM, et al. Vitamin Concentrations in Human Milk Vary with Time within Feed, Circadian Rhythm, and Single-Dose Supplementation. J Nutr. 2017;147(4):603-11. DOI:10.3945/jn.116.242941
44. Sánchez C, Fente C, Barreiro R, et al. Association between Breast Milk Mineral Content and Maternal Adherence to Healthy Dietary Patterns in Spain: A Transversal Study. Foods. 2020;9(5):659. DOI:10.3390/foods9050659
45. Vrzhesinskaya OA, Kodentsova VM, Pereverzeva OG, et al. Evaluation of sufficiency with vitamins C, B1 and B2 of newborn infants feeding different types of nutrition, by means of urinary excretion determination. Voprosy pitaniia. 2015;84(4):105-11 (in Russian)
46. Donohue JA, Solomons NW, Hampel D, et al. Micronutrient supplementation of lactating Guatemalan women acutely increases infants’ intake of riboflavin, thiamin, pyridoxal, and cobalamin, but not niacin, in a randomized crossover trial. Am J Clin Nutr. 2020;112(3):669-82. DOI:10.1093/ajcn/nqaa147
47. Daniels L, Gibson RS, Diana A, et al. Micronutrient intakes of lactating mothers and their association with breast milk concentrations and micronutrient adequacy of exclusively breastfed Indonesian infants. Am J Clin Nutr. 2019;110(2):391-400. DOI:10.1093/ajcn/nqz047
48. Mari GH, Mestorino N, Errecalde J, et al. Personalised iron supply for prophylaxis and treatment of pregnant women as a way to ensure normal iron levels in their breast milk. J Med Life. 2012;5(1):29-32.
49. Whitfield KC, Shahab-Ferdows S, Kroeun H, et al. Macro- and Micronutrients in Milk from Healthy Cambodian Mothers: Status and Interrelations. J Nutr. 2020;150(6):1461-9. DOI:10.1093/jn/nxaa070
50. Osei J, Andersson M, van der Reijden O, et al. Breast-Milk Iodine Concentrations, Iodine Status, and Thyroid Function of Breastfed Infants Aged 2–4 Months and Their Mothers Residing in a South African Township. J Clin Res Pediatr Endocrinol. 2016;8(4):381-91. DOI:10.4274/jcrpe.2720
51. Belykh NA, Korniyenko LI. Estimation of trace elements (iodine and iron) content in breast milk. Zdorov'e rebenka. 2013;5:53-7 (in Russian)
52. Nazeri P, Tahmasebinejad Z, Mehrabi Y, et al. Lactating Mothers and Infants Residing in an Area with an Effective Salt Iodization Program Have No Need for Iodine Supplements: Results from a Double-Blind, Placebo-Controlled, Randomized Controlled Trial. Thyroid. 2018;28(11):1547-58. DOI:10.1089/thy.2018.0153
53. Abe SK, Balogun OO, Ota E, et al. Supplementation with multiple micronutrients for breastfeeding women for improving outcomes for the mother and baby. Cochrane Database Syst Rev. 2016;2:CD010647. DOI:10.1002/14651858.CD010647.pub2
54. Kodentsova VM, Gmoshinskaya MV, Vrzhesinskaya OA. Vitamin-mineral supplements for pregnant and lactating women: justification of composition and doses. Reproduktivnoe zdorov'e detei i podrostkov. 2015;3:73-96 (in Russian)
55. Gromova OA, Torshin IIu, Kosheleva NG. Molekuliarnye sinergisty ioda: novye podkhody k effektivnoi profilaktike i terapii iod-defitsitnykh zabolevanii u beremennykh. RMZh. Mat' i ditia. 2011;19(1):51-8 (in Russian)
56. Gromova OA, Torshin IIu, Khadzhidis AK. Analiz molekuliarnykh mekhanizmov vozdeistviia zheleza (II), medi, margantsa v patogeneze zhelezodefitsitnoi anemii. Klinicheskaia farmakologiia i farmaekonomika. 2010;1:1-9 (in Russian)
57. Hampel D, Allen LH. Analyzing B-vitamins in Human Milk: Methodological Approaches. Crit Rev Food Sci Nutr. 2016;56(3):494-511. DOI:10.1080/10408398.2013.783550
58. Butskaya TV, Fisenko AP, Makarova SG, et al. Nutritional awareness of women of childbearing age during the breastfeeding period. Voprosy detskoi dietologii. 2020;18(2):23-30 (in Russian) DOI:10.20953/1727-57842020-2-23-30
59. Ladodo OB, Khukhreva DA, Moshkina NA, Murav'ev SM. Aktual'nye problemy grudnogo vskarmlivaniia. Meditsinskii opponent. 2020;4(12):18-23 (in Russian)
Авторы
В.М. Коденцова*1, Д.В. Рисник2, С.В. Павлович3, О.Б. Ладодо3
1 ФГБУН «Федеральный исследовательский центр питания, биотехнологии и безопасности пищи», Москва, Россия;
2 ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова», Москва, Россия;
3 ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова» Минздрава России, Москва, Россия
*kodentsova@ion.ru
1 Federal Research Center of Nutrition, Biotechnology and Food Safety, Moscow, Russia;
2 Lomonosov Moscow State University, Moscow, Russia;
3 Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia
*kodentsova@ion.ru
1 ФГБУН «Федеральный исследовательский центр питания, биотехнологии и безопасности пищи», Москва, Россия;
2 ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова», Москва, Россия;
3 ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова» Минздрава России, Москва, Россия
*kodentsova@ion.ru
________________________________________________
1 Federal Research Center of Nutrition, Biotechnology and Food Safety, Moscow, Russia;
2 Lomonosov Moscow State University, Moscow, Russia;
3 Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia
*kodentsova@ion.ru
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