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Ключевые проблемы ведения подростков и молодых женщин с обильным менструальным кровотечением
Ключевые проблемы ведения подростков и молодых женщин с обильным менструальным кровотечением
Уварова Е.В., Сальникова И.А., Хащенко Е.П., Соколова А.П. Ключевые проблемы ведения подростков и молодых женщин с обильным менструальным кровотечением. Гинекология. 2021; 23 (4): 370–376.
DOI: 10.26442/20795696.2021.4.201065
DOI: 10.26442/20795696.2021.4.201065
DOI: 10.26442/20795696.2021.4.201065
________________________________________________
DOI: 10.26442/20795696.2021.4.201065
Материалы доступны только для специалистов сферы здравоохранения. Авторизуйтесь или зарегистрируйтесь.
Аннотация
Несмотря на высокую распространенность обильных менструальных кровотечений (ОМК) у подростков и молодых женщин, большинство рекомендаций не являются специфическими для этой популяции, что затрудняет диагностику и ведение. Гинекологи должны уметь определять причины ОМК, которые у подростков чаще носят неструктурный характер, тяжесть кровотечения, чтобы поставить ранний диагноз и назначить соответствующее лечение для улучшения качества жизни и профилактики железодефицита. Терапией 1-й линии являются гормональные препараты, одобренные для лечения ОМК, способные нормализовать менструальную кровопотерю и параметры обмена железа.
Ключевые слова: обильное менструальное кровотечение, подростки, молодые женщины, менструальная кровопотеря, железодефицит, качество жизни, гормональная терапия
Keywords: heavy menstrual bleeding, adolescents, young women, menstrual blood loss, iron deficiency anemia, quality of life, hormonal therapy
Ключевые слова: обильное менструальное кровотечение, подростки, молодые женщины, менструальная кровопотеря, железодефицит, качество жизни, гормональная терапия
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Keywords: heavy menstrual bleeding, adolescents, young women, menstrual blood loss, iron deficiency anemia, quality of life, hormonal therapy
Полный текст
Список литературы
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J Pediatr Adolesc Gynecol. 2017;30:247-50. DOI:10.1016/j.jpag.2016.10.010
2. Schoep ME, Nieboer TE, van der Zanden M, et al. The impact of menstrual symptoms on everyday life: a survey among 42,879 women. Am J Obstet Gynecol. 2019;220(6):569e1-e7. DOI:10.1016/j.ajog.2019.02.048
3. NICE. NG88: Heavy menstrual bleeding: assessment and management National Institute for Health and Clinical Excellence (NICE), 2018. Available at: https://www.nice.org.uk/guidance/ng88. Accessed: 06.08.2021.
4. Klinicheskie rekomendatsii. Anomal'nye matochnye krovotecheniia v pubertatnom periode. Klinicheskie rekomendatsii. 2021 (in Russian).
5. Haamid F, Sass AE, Dietrich JE. Heavy menstrual bleeding in adolescents. J Pediatr Adolesc Gynecol. 2017;30:335-40. DOI:10.1016/j.jpag.2017.01.002
6. Uvarova EV. Anomal'nye matochnye krovotecheniia pubertatnogo perioda. Reproduktivnoe zdorov'e detei i podrostkov. 2018;1:64-91 (in Russian).
7. Committee on Adolescent Health Care. Screening and management of bleeding disorders in adolescents with heavy menstrual bleeding: ACOG Committee Opinion, Number 785. Obstet Gynecol. 2019;134(3):e71-e83. DOI:10.1097/AOG.0000000000003411
8. Munro MG, Critchley HO, Broder MS, Fraser IS; FIGO Working Group on Menstrual Disorders. FIGO classification system (PALM-COEIN) for causes of abnormal uterine bleeding in nongravid women of reproductive age. Int J Gynaecol Obstet. 2011;113:3-13. DOI:10.1016/j.ijgo.2010.11.011
9. Munro MG, Critchley HOD, Fraser IS; FIGO Menstrual Disorders Committee. The two FIGO systems for normal and abnormal uterine bleeding symptoms and classification of causes of abnormal uterine bleeding in the reproductive years: 2018 revisions. Int J Gynaecol Obstet. 2018;143:393-408. DOI:10.1002/ijgo.12666
10. Vinogradova MA. Anemiia u zhenshchin reproduktivnogo vozrasta: diagnostika i korrektsiia zhelezodefitsita. Akusherstvo i ginekologiia. 2019;6:140-5 (in Russian). DOI:10.18565/aig.2019.6.140-145
11. Munro MG. Abnormal uterine bleeding: a well-travelled path to iron deficiency and anemia. Int J Gynecol Obstet. 2020;150:275-7. DOI:10.1002/ijgo.13180
12. ACOG Practice bulletin no. 136: management of abnormal uterine bleeding associated with ovulatory dysfunction. Obstet Gynecol. 2013;122(1):176-85. DOI:10.1097/01.AOG.0000431815.52679.bb
13. Rosenfield RL. Clinical review: Adolescent anovulation: maturational mechanisms and implications. J Clin Endocrinol Metab. 2013;98(9):3572-83. DOI:10.1210/jc.2013-1770
14. Berbic M, Ng CH, Fraser IS. Inflammation and endometrial bleeding. Climacteric. 2014;17(Suppl. 2):47-53. DOI:10.3109/13697137.2014.963964
15. Zia A, Jain S, Kouides P, et al. Bleeding disorders in adolescents with heavy menstrual bleeding in a multicenter prospective US cohort. Haematologica. 2020;105(7):1969-76. DOI:10.3324/haematol.2019.225656
16. Johnson S, Lang A, Sturm M, O’Brien SH. Iron deficiency without anemia: a common yet under-recognized diagnosis in young women with heavy menstrual bleeding. J Pediatr Adolesc Gynecol. 2016;29(6):628-31. DOI:10.1016/j.jpag.2016.05.009
17. Schoep ME, Adang EMM, Maas JWM, et al. Productivity loss due to menstruation-related symptoms: a nationwide cross-sectional survey among 32 748 women. BMJ Open. 2019;9(6):e02618. DOI:10.1136/bmjopen-2018-026186
18. Camaschella C. Iron deficiency. Blood. 2019;133(1):30-9. DOI:10.1182/blood-2018-05-815944
19. Smith C, Teng F, Branch E, et al. Maternal and Perinatal Morbidity and Mortality Associated With Anemia in Pregnancy. Obstet Gynecol. 2019;134:1234-44. DOI:10.1097/AOG.0000000000003557
20. Beckert RH, Baer RJ, Anderson JG, et al. Maternal anemia and pregnancy outcomes: a population-based study. J Perinatol. 2019;39:911-9. DOI:10.1038/s41372-019-0375-0
21. Wiegersma AM, Dalman C, Lee BK, et al. Association of Prenatal Maternal Anemia With Neurodevelopmental Disorders. JAMA Psychiatry. 2019;76(12):1294-304. DOI:10.1001/jamapsychiatry.2019.2309
22. El-Nashar SA, Shazly SA. Pictorial blood loss assessment chart for quantification of menstrual blood loss: a systematic review. Gynecol Surg. 2015;12:157-63.
23. Powers JM, Buchanan GR. Diagnosis and management of iron deficiency anemia. Hematol Oncol Clin North Am. 2014;28:729-45. DOI:10.1016/j.hoc.2014.04
24. McLean E, Cogswell M, Egli I, et al. Worldwide prevalence of anaemia, WHO Vitamin and Mineral Nutrition Information System, 1993–2005. Public Health Nutr. 2009;12:444-54. DOI:10.1017/S1368980008002401
25. Sekhar DL, Murray-Kolb LE, Kunselman AR, Paul IM. Identifying factors predicting iron deficiency in United States adolescent females using the ferritin and the body iron models. Clin Nutr ESPEN. 2015;10:e118-2. DOI:10.1016/j.clnesp.2015.03.001
26. The Royal Children's Hospital, Melbourne, Australia. Clinical Practice Guideline on Adolescent gynaecology. Heavy menstrual bleeding Last Updated August 2020. Available at: https://www.rch.org.au/clinicalguide/guideline_index/Adolescent_Gynaecology_Menorrhagia/ Accessed: 06.08.2021
27. Andreeva EN. Obil'nye menstrual'nye krovotecheniia: sovremennyi podkhod k probleme i puti ee resheniia. Problemy reproduktsii. 2015;6:39-47 (in Russian). DOI:10.17116/repro201521639-47
28. Romero L, Pazol K, Warner L, et al. Vital Signs: Trends in Use of Long-Acting Reversible Contraception Among Teens Aged 15–19 Years Seeking Contraceptive Services – United States, 2005–2013. MMWR. 2015;64(13):363-9. Available at: http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6413a6.htm. Accessed: 06.08.2021
29. Diedrich JT, Klein DA, Peipert JF. Long-acting reversible contraception in adolescents: a systematic review and meta-analysis. Am J Obstet Gynecol. 2017;216(4):364.e1-364.e12. DOI:10.1016/j.ajog.2016.12.024
30. Counseling adolescents about contraception. Committee Opinion No. 710. American College of Obstetricians and Gynecologists. Obstet Gynecol. 2017;130:e74-80. DOI:10.1097/AOG.0000000000002234
31. Lethaby A, Hussain M, Rishworth JR, Rees MC. Progesterone or progestogen-releasing intrauterine systems for heavy menstrual bleeding. Cochrane Database Syst Rev. 2015;CD002126. DOI:10.1002/14651858.CD002126.pub3
32. Shabaan MM, Zakherah MS, El-Nashar SA, Sayed GH. Levonorgestrel-releasing intrauterine system compared to low dose combined oral contraceptive pills for idiopathic menorrhagia: A randomized clinical trial. Contraception. 2011;83:48-54.DOI:10.1016/j.contraception.2010.06.011
33. Levy-Zauberman Y, Pourcelot AG, Capmas P, Fernandez H. Update on the management of abnormal uterine bleeding. J Gynecol Obstet Hum Reprod. 2017;46:613-2.
34. Kowalczyk Mullins TL, Miller RJ, Mullins ES. Evaluation and management of adolescents with abnormal uterine bleeding. Pediatr Ann. 2015;44:e218-22.
DOI:10.3928/00904481-20150910-09
35. Adeyemi-Fowode OA, Santos XM, Dietrich JE, Srivaths L. Levonorgestrel-releasing intrauterine device use in female adolescents with heavy menstrual bleeding and bleeding disorders: single institution review. J Pediatr Adolesc Gynecol. 2016;30:479-83. DOI:10.1016/j.jpag.2016.04.001
36. Moon LM, Perez-Milicua G, Dietrich JE. Evaluation and management of heavy menstrual bleeding in adolescents. Curr Opin Obstet Gynecol. 2017;29:328-36. DOI:10.1097/GCO.0000000000000394
37. Lethaby A, Wise MR, Weterings MA, et al. Combined hormonal contraceptives for heavy menstrual bleeding. Cochrane Database Syst Rev. 2019;2(2):CD000154. DOI:10.1002/14651858.CD000154.pub3
38. Farquhar C, Brown J. Oral contraceptive pill for heavy menstrual bleeding. Cochrane Database Syst Rev. 2009;4:CD000154. DOI:10.1002/14651858.CD000154
39. Fraser IS, Jensen JT. Effective treatment of heavy and/or prolonged menstrual bleeding with an oral contraceptive containing estradiol valerate and dienogest: a randomized, double-blind Phase III trial. Hum Reprod. 2011;26(10):2698-708. DOI:10.1093/humrep/der224
40. Jensen JT, Parke S, Mellinger U. Effective treatment of heavy menstrual bleeding with estradiol valerate and dienogest: a randomized controlled trial. Obstet Gynecol. 2011;117(4):777-8. DOI:10.1097/AOG.0b013e3182118ac3
41. Yu Q, Zhou Y, Suturina L, et al. Efficacy and Safety of Estradiol Valerate/Dienogest for the Management of Heavy Menstrual Bleeding:
A Multicenter, Double-Blind, Randomized, Placebo-Controlled, Phase III Clinical Trial. J Womens Health (Larchmt). 2018;27(10):1225-32. DOI:10.1089/jwh.2017.6522
42. Guida M, Bifulco G, Di Spiezio Sardo A, et al. Review of the safety, efficacy and patient acceptability of the combined dienogest/estradiol valerate contraceptive pill. Intern J Women’s Health. 2010;2:279-90. DOI:10.2147/IJWH.S6954
43. Maybin JA, Hirani N, Brown P, et al. The Regulation of Vascular Endothelial Growth Factor by Hypoxia and Prostaglandin F2α during Human Endometrial Repair. J Clin Endocrinol Metab. 2011;96:2475-83.
44. Grandi G, Mueller M, Bersinger NA, et al. Does dienogest influence the inflammatory response of endometriotic cells? A systematic review. Inflamm Res. 2016;65(3):183-92. DOI:10.1007/s00011-015-0909-7
45. Jensen JT, Bitzer J, Nappi RE, et al. Pooled analysis of bleeding profile, efficacy and safety of oral oestradiol valerate/dienogest in women aged 25 and under. Eur J Contracept Reprod Health Care. 2020;25(2):98-105. DOI:10.1080/13625187.2020.1731734
46. Gerasimov AM. Opyt ispol'zovaniia kombinatsii estradiola valerata i dienogesta s tsel'iu kontratseptsii i lecheniia obil'nykh menstrual'nykh krovotechenii v programme pregravidarnoi podgotovki zhenshchin s khronicheskim endometritom. Problemy reproduktsii. 2016;22(6):44-50 (in Russian).
47. Dobrokhotova IuE, Ibragimova DM, Grishin II. Menorragiia: est' li puti resheniia? Meditsinskii sovet. 2016;(12):12-3 (in Russian). DOI:10.21518/2079-701X-2016-12-12-13
48. Prilepskaia VN. Estradiola valerat i dienogest v gormonal'noi kontratseptsii. Priemlemost' i effektivnost' v real'noi klinicheskoi praktike. Meditsinskii sovet. 2018(13):20-4 (in Russian).
49. Dinger J, Möhner S, Heinemann K. Combined oral contraceptives containing dienogest and estradiol valerate may carry a lower risk of venous and arterial thromboembolism compared to conventional preparations: Results from the extended INAS-SCORE study. Front Womens Healt. 2020;5:1-8. DOI:10.15761/FWH.1000178
50. Drapkina OM, Martynov AI, Baida AP, et al. Rezoliutsiia ekspertnogo soveta "Aktual'nye voprosy zhelezodefitsita v Rossiiskoi Federatsii". Kardiovaskuliarnaia terapiia i profilaktika. 2020;19(5):2700 (in Russian). DOI:10.15829/1728-8800-2020-2700
51. Ramalho I, Leite H, Águas F. Abnormal uterine bleeding in adolescents. Acta Med Port. 2021;34(4):291-7. DOI:10.20344/amp.12829
52. Cooke AG, McCavit TL, Buchanan GR, Powers JM. Iron deficiency anemia in adolescents who present with heavy menstrual bleeding.
J Pediatr Adolesc Gynecol. 2017;30:247-50. DOI:10.1016/j.jpag.2016.10.010
2. Schoep ME, Nieboer TE, van der Zanden M, et al. The impact of menstrual symptoms on everyday life: a survey among 42,879 women. Am J Obstet Gynecol. 2019;220(6):569e1-e7. DOI:10.1016/j.ajog.2019.02.048
3. NICE. NG88: Heavy menstrual bleeding: assessment and management National Institute for Health and Clinical Excellence (NICE), 2018. Available at: https://www.nice.org.uk/guidance/ng88. Accessed: 06.08.2021.
4. Клинические рекомендации. Аномальные маточные кровотечения в пубертатном периоде. Клинические рекомендации. 2021 [Klinicheskie rekomendatsii. Anomal'nye matochnye krovotecheniia v pubertatnom periode. Klinicheskie rekomendatsii. 2021 (in Russian)].
5. Haamid F, Sass AE, Dietrich JE. Heavy menstrual bleeding in adolescents. J Pediatr Adolesc Gynecol. 2017;30:335-40.
DOI:10.1016/j.jpag.2017.01.002
6. Уварова Е.В. Аномальные маточные кровотечения пубертатного периода. Репродуктивное здоровье детей и подростков. 2018;1:64-91 [Uvarova EV. Anomal'nye matochnye krovotecheniia pubertatnogo perioda. Reproduktivnoe zdorov'e detei i podrostkov. 2018;1:64-91
(in Russian)].
7. Committee on Adolescent Health Care. Screening and management of bleeding disorders in adolescents with heavy menstrual bleeding: ACOG Committee Opinion, Number 785. Obstet Gynecol. 2019;134(3):e71-e83. DOI:10.1097/AOG.0000000000003411
8. Munro MG, Critchley HO, Broder MS, Fraser IS; FIGO Working Group on Menstrual Disorders. FIGO classification system (PALM-COEIN) for causes of abnormal uterine bleeding in nongravid women of reproductive age. Int J Gynaecol Obstet. 2011;113:3-13. DOI:10.1016/j.ijgo.2010.11.011
9. Munro MG, Critchley HOD, Fraser IS; FIGO Menstrual Disorders Committee. The two FIGO systems for normal and abnormal uterine bleeding symptoms and classification of causes of abnormal uterine bleeding in the reproductive years: 2018 revisions. Int J Gynaecol Obstet. 2018;143:393-408. DOI:10.1002/ijgo.12666
10. Виноградова М.А. Анемия у женщин репродуктивного возраста: диагностика и коррекция железодефицита. Акушерство и гинекология. 2019;6:140-5 [Vinogradova MA. Anemiia u zhenshchin reproduktivnogo vozrasta: diagnostika i korrektsiia zhelezodefitsita. Akusherstvo i ginekologiia. 2019;6:140-5 (in Russian)]. DOI:10.18565/aig.2019.6.140-145
11. Munro MG. Abnormal uterine bleeding: a well-travelled path to iron deficiency and anemia. Int J Gynecol Obstet. 2020;150:275-7. DOI:10.1002/ijgo.13180
12. ACOG Practice bulletin no. 136: management of abnormal uterine bleeding associated with ovulatory dysfunction. Obstet Gynecol. 2013;122(1):176-85. DOI:10.1097/01.AOG.0000431815.52679.bb
13. Rosenfield RL. Clinical review: Adolescent anovulation: maturational mechanisms and implications. J Clin Endocrinol Metab. 2013;98(9):3572-83. DOI:10.1210/jc.2013-1770
14. Berbic M, Ng CH, Fraser IS. Inflammation and endometrial bleeding. Climacteric. 2014;17(Suppl. 2):47-53. DOI:10.3109/13697137.2014.963964
15. Zia A, Jain S, Kouides P, et al. Bleeding disorders in adolescents with heavy menstrual bleeding in a multicenter prospective US cohort. Haematologica. 2020;105(7):1969-76. DOI:10.3324/haematol.2019.225656
16. Johnson S, Lang A, Sturm M, O’Brien SH. Iron deficiency without anemia: a common yet under-recognized diagnosis in young women with heavy menstrual bleeding. J Pediatr Adolesc Gynecol. 2016;29(6):628-31. DOI:10.1016/j.jpag.2016.05.009
17. Schoep ME, Adang EMM, Maas JWM, et al. Productivity loss due to menstruation-related symptoms: a nationwide cross-sectional survey among 32 748 women. BMJ Open. 2019;9(6):e02618. DOI:10.1136/bmjopen-2018-026186
18. Camaschella C. Iron deficiency. Blood. 2019;133(1):30-9. DOI:10.1182/blood-2018-05-815944
19. Smith C, Teng F, Branch E, et al. Maternal and Perinatal Morbidity and Mortality Associated With Anemia in Pregnancy. Obstet Gynecol. 2019;134:1234-44. DOI:10.1097/AOG.0000000000003557
20. Beckert RH, Baer RJ, Anderson JG, et al. Maternal anemia and pregnancy outcomes: a population-based study. J Perinatol. 2019;39:911-9. DOI:10.1038/s41372-019-0375-0
21. Wiegersma AM, Dalman C, Lee BK, et al. Association of Prenatal Maternal Anemia With Neurodevelopmental Disorders. JAMA Psychiatry. 2019;76(12):1294-304. DOI:10.1001/jamapsychiatry.2019.2309
22. El-Nashar SA, Shazly SA. Pictorial blood loss assessment chart for quantification of menstrual blood loss: a systematic review. Gynecol Surg. 2015;12:157-63.
23. Powers JM, Buchanan GR. Diagnosis and management of iron deficiency anemia. Hematol Oncol Clin North Am. 2014;28:729-45.
DOI:10.1016/j.hoc.2014.04
24. McLean E, Cogswell M, Egli I, et al. Worldwide prevalence of anaemia, WHO Vitamin and Mineral Nutrition Information System, 1993–2005. Public Health Nutr. 2009;12:444-54. DOI:10.1017/S1368980008002401
25. Sekhar DL, Murray-Kolb LE, Kunselman AR, Paul IM. Identifying factors predicting iron deficiency in United States adolescent females using the ferritin and the body iron models. Clin Nutr ESPEN. 2015;10:e118-2. DOI:10.1016/j.clnesp.2015.03.001
26. The Royal Children's Hospital, Melbourne, Australia. Clinical Practice Guideline on Adolescent gynaecology. Heavy menstrual bleeding
Last Updated August 2020. Available at: https://www.rch.org.au/clinicalguide/guideline_index/Adolescent_Gynaecology_Menorrhagia/ Accessed: 06.08.2021
27. Андреева Е.Н. Обильные менструальные кровотечения: современный подход к проблеме и пути ее решения. Проблемы репродукции. 2015;6:39-47 [Andreeva EN. Obil'nye menstrual'nye krovotecheniia: sovremennyi podkhod k probleme i puti ee resheniia. Problemy reproduktsii. 2015;6:39-47 (in Russian)]. DOI:10.17116/repro201521639-47
28. Romero L, Pazol K, Warner L, et al. Vital Signs: Trends in Use of Long-Acting Reversible Contraception Among Teens Aged 15–19 Years Seeking Contraceptive Services – United States, 2005–2013. MMWR. 2015;64(13):363-9. Available at: http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6413a6.htm. Accessed: 06.08.2021
29. Diedrich JT, Klein DA, Peipert JF. Long-acting reversible contraception in adolescents: a systematic review and meta-analysis. Am J Obstet Gynecol. 2017;216(4):364.e1-364.e12. DOI:10.1016/j.ajog.2016.12.024
30. Counseling adolescents about contraception. Committee Opinion No. 710. American College of Obstetricians and Gynecologists. Obstet Gynecol. 2017;130:e74-80. DOI:10.1097/AOG.0000000000002234
31. Lethaby A, Hussain M, Rishworth JR, Rees MC. Progesterone or progestogen-releasing intrauterine systems for heavy menstrual bleeding. Cochrane Database Syst Rev. 2015;CD002126. DOI:10.1002/14651858.CD002126.pub3
32. Shabaan MM, Zakherah MS, El-Nashar SA, Sayed GH. Levonorgestrel-releasing intrauterine system compared to low dose combined oral contraceptive pills for idiopathic menorrhagia: A randomized clinical trial. Contraception. 2011;83:48-54.DOI:10.1016/j.contraception.2010.06.011
33. Levy-Zauberman Y, Pourcelot AG, Capmas P, Fernandez H. Update on the management of abnormal uterine bleeding. J Gynecol Obstet Hum Reprod. 2017;46:613-2.
34. Kowalczyk Mullins TL, Miller RJ, Mullins ES. Evaluation and management of adolescents with abnormal uterine bleeding. Pediatr Ann. 2015;44:e218-22.
DOI:10.3928/00904481-20150910-09
35. Adeyemi-Fowode OA, Santos XM, Dietrich JE, Srivaths L. Levonorgestrel-releasing intrauterine device use in female adolescents with heavy menstrual bleeding and bleeding disorders: single institution review. J Pediatr Adolesc Gynecol. 2016;30:479-83. DOI:10.1016/j.jpag.2016.04.001
36. Moon LM, Perez-Milicua G, Dietrich JE. Evaluation and management of heavy menstrual bleeding in adolescents. Curr Opin Obstet Gynecol. 2017;29:328-36. DOI:10.1097/GCO.0000000000000394
37. Lethaby A, Wise MR, Weterings MA, et al. Combined hormonal contraceptives for heavy menstrual bleeding. Cochrane Database Syst Rev. 2019;2(2):CD000154. DOI:10.1002/14651858.CD000154.pub3
38. Farquhar C, Brown J. Oral contraceptive pill for heavy menstrual bleeding. Cochrane Database Syst Rev. 2009;4:CD000154.
DOI:10.1002/14651858.CD000154
39. Fraser IS, Jensen JT. Effective treatment of heavy and/or prolonged menstrual bleeding with an oral contraceptive containing estradiol valerate and dienogest: a randomized, double-blind Phase III trial. Hum Reprod. 2011;26(10):2698-708. DOI:10.1093/humrep/der224
40. Jensen JT, Parke S, Mellinger U. Effective treatment of heavy menstrual bleeding with estradiol valerate and dienogest: a randomized controlled trial. Obstet Gynecol. 2011;117(4):777-8. DOI:10.1097/AOG.0b013e3182118ac3
41. Yu Q, Zhou Y, Suturina L, et al. Efficacy and Safety of Estradiol Valerate/Dienogest for the Management of Heavy Menstrual Bleeding:
A Multicenter, Double-Blind, Randomized, Placebo-Controlled, Phase III Clinical Trial. J Womens Health (Larchmt). 2018;27(10):1225-32. DOI:10.1089/jwh.2017.6522
42. Guida M, Bifulco G, Di Spiezio Sardo A, et al. Review of the safety, efficacy and patient acceptability of the combined dienogest/estradiol valerate contraceptive pill. Intern J Women’s Health. 2010;2:279-90. DOI:10.2147/IJWH.S6954
43. Maybin JA, Hirani N, Brown P, et al. The Regulation of Vascular Endothelial Growth Factor by Hypoxia and Prostaglandin F2α during Human Endometrial Repair. J Clin Endocrinol Metab. 2011;96:2475-83.
44. Grandi G, Mueller M, Bersinger NA, et al. Does dienogest influence the inflammatory response of endometriotic cells? A systematic review. Inflamm Res. 2016;65(3):183-92. DOI:10.1007/s00011-015-0909-7
45. Jensen JT, Bitzer J, Nappi RE, et al. Pooled analysis of bleeding profile, efficacy and safety of oral oestradiol valerate/dienogest in women aged 25 and under. Eur J Contracept Reprod Health Care. 2020;25(2):98-105. DOI:10.1080/13625187.2020.1731734
46. Герасимов А.М. Опыт использования комбинации эстрадиола валерата и диеногеста с целью контрацепции и лечения обильных менструальных кровотечений в программе прегравидарной подготовки женщин с хроническим эндометритом. Проблемы репродукции. 2016;22(6):44-50 [Gerasimov AM. Opyt ispol'zovaniia kombinatsii estradiola valerata i dienogesta s tsel'iu kontratseptsii i lecheniia obil'nykh menstrual'nykh krovotechenii v programme pregravidarnoi podgotovki zhenshchin s khronicheskim endometritom. Problemy reproduktsii. 2016;22(6):44-50 (in Russian)].
47. Доброхотова Ю.Э., Ибрагимова Д.М., Гришин И.И. Меноррагия: есть ли пути решения? Медицинский совет. 2016;(12):12-3 [Dobrokhotova IuE, Ibragimova DM, Grishin II. Menorragiia: est' li puti resheniia? Meditsinskii sovet. 2016;(12):12-3 (in Russian)]. DOI:10.21518/2079-701X-2016-12-12-13
48. Прилепская В.Н. Эстрадиола валерат и диеногест в гормональной контрацепции. Приемлемость и эффективность в реальной клинической практике. Медицинский совет. 2018(13):20-4 [Prilepskaia VN. Estradiola valerat i dienogest v gormonal'noi kontratseptsii. Priemlemost' i effektivnost' v real'noi klinicheskoi praktike. Meditsinskii sovet. 2018(13):20-4 (in Russian)].
49. Dinger J, Möhner S, Heinemann K. Combined oral contraceptives containing dienogest and estradiol valerate may carry a lower risk of venous and arterial thromboembolism compared to conventional preparations: Results from the extended INAS-SCORE study. Front Womens Healt. 2020;5:1-8. DOI:10.15761/FWH.1000178
50. Драпкина О.М., Мартынов А.И., Байда А.П., и др. Резолюция экспертного совета «Актуальные вопросы железодефицита в Российской Федерации». Кардиоваскулярная терапия и профилактика. 2020;19(5):2700 [Drapkina OM, Martynov AI, Baida AP, et al. Rezoliutsiia ekspertnogo soveta "Aktual'nye voprosy zhelezodefitsita v Rossiiskoi Federatsii". Kardiovaskuliarnaia terapiia i profilaktika. 2020;19(5):2700 (in Russian)]. DOI:10.15829/1728-8800-2020-2700
51. Ramalho I, Leite H, Águas F. Abnormal uterine bleeding in adolescents. Acta Med Port. 2021;34(4):291-7. DOI:10.20344/amp.12829
52. Cooke AG, McCavit TL, Buchanan GR, Powers JM. Iron deficiency anemia in adolescents who present with heavy menstrual bleeding.
J Pediatr Adolesc Gynecol. 2017;30:247-50. DOI:10.1016/j.jpag.2016.10.010
________________________________________________
2. Schoep ME, Nieboer TE, van der Zanden M, et al. The impact of menstrual symptoms on everyday life: a survey among 42,879 women. Am J Obstet Gynecol. 2019;220(6):569e1-e7. DOI:10.1016/j.ajog.2019.02.048
3. NICE. NG88: Heavy menstrual bleeding: assessment and management National Institute for Health and Clinical Excellence (NICE), 2018. Available at: https://www.nice.org.uk/guidance/ng88. Accessed: 06.08.2021.
4. Klinicheskie rekomendatsii. Anomal'nye matochnye krovotecheniia v pubertatnom periode. Klinicheskie rekomendatsii. 2021 (in Russian).
5. Haamid F, Sass AE, Dietrich JE. Heavy menstrual bleeding in adolescents. J Pediatr Adolesc Gynecol. 2017;30:335-40. DOI:10.1016/j.jpag.2017.01.002
6. Uvarova EV. Anomal'nye matochnye krovotecheniia pubertatnogo perioda. Reproduktivnoe zdorov'e detei i podrostkov. 2018;1:64-91 (in Russian).
7. Committee on Adolescent Health Care. Screening and management of bleeding disorders in adolescents with heavy menstrual bleeding: ACOG Committee Opinion, Number 785. Obstet Gynecol. 2019;134(3):e71-e83. DOI:10.1097/AOG.0000000000003411
8. Munro MG, Critchley HO, Broder MS, Fraser IS; FIGO Working Group on Menstrual Disorders. FIGO classification system (PALM-COEIN) for causes of abnormal uterine bleeding in nongravid women of reproductive age. Int J Gynaecol Obstet. 2011;113:3-13. DOI:10.1016/j.ijgo.2010.11.011
9. Munro MG, Critchley HOD, Fraser IS; FIGO Menstrual Disorders Committee. The two FIGO systems for normal and abnormal uterine bleeding symptoms and classification of causes of abnormal uterine bleeding in the reproductive years: 2018 revisions. Int J Gynaecol Obstet. 2018;143:393-408. DOI:10.1002/ijgo.12666
10. Vinogradova MA. Anemiia u zhenshchin reproduktivnogo vozrasta: diagnostika i korrektsiia zhelezodefitsita. Akusherstvo i ginekologiia. 2019;6:140-5 (in Russian). DOI:10.18565/aig.2019.6.140-145
11. Munro MG. Abnormal uterine bleeding: a well-travelled path to iron deficiency and anemia. Int J Gynecol Obstet. 2020;150:275-7. DOI:10.1002/ijgo.13180
12. ACOG Practice bulletin no. 136: management of abnormal uterine bleeding associated with ovulatory dysfunction. Obstet Gynecol. 2013;122(1):176-85. DOI:10.1097/01.AOG.0000431815.52679.bb
13. Rosenfield RL. Clinical review: Adolescent anovulation: maturational mechanisms and implications. J Clin Endocrinol Metab. 2013;98(9):3572-83. DOI:10.1210/jc.2013-1770
14. Berbic M, Ng CH, Fraser IS. Inflammation and endometrial bleeding. Climacteric. 2014;17(Suppl. 2):47-53. DOI:10.3109/13697137.2014.963964
15. Zia A, Jain S, Kouides P, et al. Bleeding disorders in adolescents with heavy menstrual bleeding in a multicenter prospective US cohort. Haematologica. 2020;105(7):1969-76. DOI:10.3324/haematol.2019.225656
16. Johnson S, Lang A, Sturm M, O’Brien SH. Iron deficiency without anemia: a common yet under-recognized diagnosis in young women with heavy menstrual bleeding. J Pediatr Adolesc Gynecol. 2016;29(6):628-31. DOI:10.1016/j.jpag.2016.05.009
17. Schoep ME, Adang EMM, Maas JWM, et al. Productivity loss due to menstruation-related symptoms: a nationwide cross-sectional survey among 32 748 women. BMJ Open. 2019;9(6):e02618. DOI:10.1136/bmjopen-2018-026186
18. Camaschella C. Iron deficiency. Blood. 2019;133(1):30-9. DOI:10.1182/blood-2018-05-815944
19. Smith C, Teng F, Branch E, et al. Maternal and Perinatal Morbidity and Mortality Associated With Anemia in Pregnancy. Obstet Gynecol. 2019;134:1234-44. DOI:10.1097/AOG.0000000000003557
20. Beckert RH, Baer RJ, Anderson JG, et al. Maternal anemia and pregnancy outcomes: a population-based study. J Perinatol. 2019;39:911-9. DOI:10.1038/s41372-019-0375-0
21. Wiegersma AM, Dalman C, Lee BK, et al. Association of Prenatal Maternal Anemia With Neurodevelopmental Disorders. JAMA Psychiatry. 2019;76(12):1294-304. DOI:10.1001/jamapsychiatry.2019.2309
22. El-Nashar SA, Shazly SA. Pictorial blood loss assessment chart for quantification of menstrual blood loss: a systematic review. Gynecol Surg. 2015;12:157-63.
23. Powers JM, Buchanan GR. Diagnosis and management of iron deficiency anemia. Hematol Oncol Clin North Am. 2014;28:729-45. DOI:10.1016/j.hoc.2014.04
24. McLean E, Cogswell M, Egli I, et al. Worldwide prevalence of anaemia, WHO Vitamin and Mineral Nutrition Information System, 1993–2005. Public Health Nutr. 2009;12:444-54. DOI:10.1017/S1368980008002401
25. Sekhar DL, Murray-Kolb LE, Kunselman AR, Paul IM. Identifying factors predicting iron deficiency in United States adolescent females using the ferritin and the body iron models. Clin Nutr ESPEN. 2015;10:e118-2. DOI:10.1016/j.clnesp.2015.03.001
26. The Royal Children's Hospital, Melbourne, Australia. Clinical Practice Guideline on Adolescent gynaecology. Heavy menstrual bleeding Last Updated August 2020. Available at: https://www.rch.org.au/clinicalguide/guideline_index/Adolescent_Gynaecology_Menorrhagia/ Accessed: 06.08.2021
27. Andreeva EN. Obil'nye menstrual'nye krovotecheniia: sovremennyi podkhod k probleme i puti ee resheniia. Problemy reproduktsii. 2015;6:39-47 (in Russian). DOI:10.17116/repro201521639-47
28. Romero L, Pazol K, Warner L, et al. Vital Signs: Trends in Use of Long-Acting Reversible Contraception Among Teens Aged 15–19 Years Seeking Contraceptive Services – United States, 2005–2013. MMWR. 2015;64(13):363-9. Available at: http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6413a6.htm. Accessed: 06.08.2021
29. Diedrich JT, Klein DA, Peipert JF. Long-acting reversible contraception in adolescents: a systematic review and meta-analysis. Am J Obstet Gynecol. 2017;216(4):364.e1-364.e12. DOI:10.1016/j.ajog.2016.12.024
30. Counseling adolescents about contraception. Committee Opinion No. 710. American College of Obstetricians and Gynecologists. Obstet Gynecol. 2017;130:e74-80. DOI:10.1097/AOG.0000000000002234
31. Lethaby A, Hussain M, Rishworth JR, Rees MC. Progesterone or progestogen-releasing intrauterine systems for heavy menstrual bleeding. Cochrane Database Syst Rev. 2015;CD002126. DOI:10.1002/14651858.CD002126.pub3
32. Shabaan MM, Zakherah MS, El-Nashar SA, Sayed GH. Levonorgestrel-releasing intrauterine system compared to low dose combined oral contraceptive pills for idiopathic menorrhagia: A randomized clinical trial. Contraception. 2011;83:48-54.DOI:10.1016/j.contraception.2010.06.011
33. Levy-Zauberman Y, Pourcelot AG, Capmas P, Fernandez H. Update on the management of abnormal uterine bleeding. J Gynecol Obstet Hum Reprod. 2017;46:613-2.
34. Kowalczyk Mullins TL, Miller RJ, Mullins ES. Evaluation and management of adolescents with abnormal uterine bleeding. Pediatr Ann. 2015;44:e218-22.
DOI:10.3928/00904481-20150910-09
35. Adeyemi-Fowode OA, Santos XM, Dietrich JE, Srivaths L. Levonorgestrel-releasing intrauterine device use in female adolescents with heavy menstrual bleeding and bleeding disorders: single institution review. J Pediatr Adolesc Gynecol. 2016;30:479-83. DOI:10.1016/j.jpag.2016.04.001
36. Moon LM, Perez-Milicua G, Dietrich JE. Evaluation and management of heavy menstrual bleeding in adolescents. Curr Opin Obstet Gynecol. 2017;29:328-36. DOI:10.1097/GCO.0000000000000394
37. Lethaby A, Wise MR, Weterings MA, et al. Combined hormonal contraceptives for heavy menstrual bleeding. Cochrane Database Syst Rev. 2019;2(2):CD000154. DOI:10.1002/14651858.CD000154.pub3
38. Farquhar C, Brown J. Oral contraceptive pill for heavy menstrual bleeding. Cochrane Database Syst Rev. 2009;4:CD000154. DOI:10.1002/14651858.CD000154
39. Fraser IS, Jensen JT. Effective treatment of heavy and/or prolonged menstrual bleeding with an oral contraceptive containing estradiol valerate and dienogest: a randomized, double-blind Phase III trial. Hum Reprod. 2011;26(10):2698-708. DOI:10.1093/humrep/der224
40. Jensen JT, Parke S, Mellinger U. Effective treatment of heavy menstrual bleeding with estradiol valerate and dienogest: a randomized controlled trial. Obstet Gynecol. 2011;117(4):777-8. DOI:10.1097/AOG.0b013e3182118ac3
41. Yu Q, Zhou Y, Suturina L, et al. Efficacy and Safety of Estradiol Valerate/Dienogest for the Management of Heavy Menstrual Bleeding:
A Multicenter, Double-Blind, Randomized, Placebo-Controlled, Phase III Clinical Trial. J Womens Health (Larchmt). 2018;27(10):1225-32. DOI:10.1089/jwh.2017.6522
42. Guida M, Bifulco G, Di Spiezio Sardo A, et al. Review of the safety, efficacy and patient acceptability of the combined dienogest/estradiol valerate contraceptive pill. Intern J Women’s Health. 2010;2:279-90. DOI:10.2147/IJWH.S6954
43. Maybin JA, Hirani N, Brown P, et al. The Regulation of Vascular Endothelial Growth Factor by Hypoxia and Prostaglandin F2α during Human Endometrial Repair. J Clin Endocrinol Metab. 2011;96:2475-83.
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Авторы
Е.В. Уварова*1,2, И.А. Сальникова1, Е.П. Хащенко1, А.П. Соколова3
1 ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова» Минздрава России, Москва, Россия;
2 ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет), Москва, Россия;
3 АО «Байер», Москва, Россия
*elena-uvarova@yandex.ru
1 Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia;
2 Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia;
3 JSC "Bayer", Moscow, Russia
*elena-uvarova@yandex.ru
1 ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии имени академика В.И. Кулакова» Минздрава России, Москва, Россия;
2 ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет), Москва, Россия;
3 АО «Байер», Москва, Россия
*elena-uvarova@yandex.ru
________________________________________________
1 Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia;
2 Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia;
3 JSC "Bayer", Moscow, Russia
*elena-uvarova@yandex.ru
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