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Перспективы применения экзогенных инозитолов для поддержания состояния кожи, волос и ногтей
Перспективы применения экзогенных инозитолов для поддержания состояния кожи, волос и ногтей
Громова О.А., Торшин И.Ю., Тетруашвили Н.К. Перспективы применения экзогенных инозитолов для поддержания состояния кожи, волос и ногтей. Гинекология. 2022;24(4):261–270. DOI: 10.26442/20795696.2022.4.201824
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Аннотация
Миоинозитол (МИ) и D-хироинозитол (ДХИ), использующиеся в терапии нарушений менструального цикла, синдрома поликистоза яичников (СПЯ), гирсутизма, акне, гестационного диабета и других заболеваний, необходимы для внутриклеточной передачи сигнала от рецепторов инсулина и от других гормональных рецепторов. Клинический опыт показывает, что МИ и ДХИ, например в терапии СПЯ, оказывают положительное действие на состояние кожи, волос и ногтей. Эти эффекты МИ и ДХИ связаны не только с нормализацией передачи «инсулиновых» сигналов, но и с поддержкой дифференцировки и роста различных типов клеток кожи (кератиноцитов, фибробластов, эпителиоцитов и т.д.). Воздействие МИ и ДХИ на кожу и ее придатки, в том числе при заживлении ран, может быть усилено марганцем, который дает антиоксидантный эффект и улучшает состояние соединительно-тканной основы кожи, и фолиевой кислотой, участвующей в обмене аминокислот, пролиферации и дифференцировке делящихся клеток.
Ключевые слова: миоинозитол, D-хироинозитол, марганец, фолиевая кислота, кожа, Дикироген
Keywords: myoinositol, D-chiroinositol, manganese, skin, Dikirogen
Ключевые слова: миоинозитол, D-хироинозитол, марганец, фолиевая кислота, кожа, Дикироген
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Keywords: myoinositol, D-chiroinositol, manganese, skin, Dikirogen
Полный текст
Список литературы
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2. Limanova OA, Gromova OA, Torshin IYu, et al. Systematic analysis of molecular mechanisms and physiological effects of myo-inositol: findings of molecular biology, experimental and clinical medicine. Effective pharmacotherapy. 2013;28:32-41 (in Russian).
3. Claxson A, Morris C, Blake D, et al. The anti-inflammatory effects of D-myo-inositol-1.2.6-trisphosphate (PP56) on animal models of inflammation. Agents Actions. 1990;29(1-2):68-70. DOI:10.1007/BF01964724
4. Catolla-cavalcanti A. Effect of inositol on cicatrization time of burns. Minerva Med. 1955;46(80):838-40.
5. Plascencia Gómez A, Vega Memije ME, Torres Tamayo M, Rodríguez Carreón AA. Skin disorders in overweight and obese patients and relationship with insulin. Actas Dermosifiliogr. 2014;105(2):178-85. DOI:10.1016/j.ad.2013.09.008
6. Hrynyk M, Neufeld RJ. Insulin and wound healing. Burns. 2014;40(8):1433-46. DOI:10.1016/j.burns.2014.03.020
7. Liu Y, Petreaca M, Yao M, Martins-Green M. Cell and molecular mechanisms of keratinocyte function stimulated by insulin during wound healing. BMC Cell Biol. 2009;10:1. DOI:10.1186/1471-2121-10-1
8. Chen X, Liu Y, Zhang X. Topical insulin application improves healing by regulating the wound inflammatory response. Wound Repair Regen. 2012;20(3):425-34.
DOI:10.1111/j.1524-475X.2012.00792.x
9. Gauglitz GG, Toliver-Kinsky TE, Williams FN, et al. Insulin increases resistance to burn wound infection-associated sepsis. Crit Care Med. 2010;38(1):202-8. DOI:10.1097/CCM.0b013e3181b43236
10. Tuvdendorj D, Zhang XJ, Chinkes DL, et al. Intensive insulin treatment increases donor site wound protein synthesis in burn patients. Surgery. 2011;149(4):512-8. DOI:10.1016/j.surg.2010.10.021
11. Otranto M, Nascimento AP, Monte-Alto-Costa A. Insulin resistance impairs cutaneous wound healing in mice. Wound Repair Regen. 2013;21(3):464-72. DOI:10.1111/wrr.12042
12. Gromova OA, Torshin IYu, Uvarova EV, et al. Systematic analysis of the biological roles and pharmacological properties of D-chiro-inositol. Gynecology. 2020;22(3):21-8 (in Russian). DOI:10.26442/20795696.2020.3.200210
13. Baillargeon JP, Iuorno MJ, Apridonidze T, Nestler JE. Uncoupling between insulin and release of a D-chiro-inositol-containing inositolphosphoglycan mediator of insulin action in obese women with polycystic ovary syndrome. Metab Syndr Relat Disord. 2010;8(2):127-36. DOI:10.1089/met.2009.0052
14. Croze ML, Vella RE, Pillon NJ, et al. Chronic treatment with myo-inositol reduces white adipose tissue accretion and improves insulin sensitivity in female mice. J Nutr Biochem. 2013;24(2):457-66. DOI:10.1016/j.jnutbio.2012.01.008
15. Wang JM, Qiu Y, Yang ZQ, et al. Inositol-Requiring Enzyme 1 Facilitates Diabetic Wound Healing Through Modulating MicroRNAs. Diabetes. 2017;66(1):177-92.
DOI:10.2337/db16-0052
16. Rezvani O, Shabbak E, Aslani A, et al. A randomized, double-blind, placebo-controlled trial to determine the effects of topical insulin on wound healing. Ostomy Wound Manage. 2009;55(8):22-8.
17. Januszewski M, Issat T, Jakimiuk AA, Santor-Zaczynska M. Metabolic and hormonal effects of a combined Myo-inositol and d-chiro-inositol therapy on patients with polycystic ovary syndrome. Ginekol Pol. 2019;90(1):7-10. DOI:10.5603/GP.2019.0002
18. Nestler JE, Jakubowicz DJ, de Vargas AF, et al. Insulin stimulates testosterone biosynthesis by human thecal cells from women with polycystic ovary syndrome by activating its own receptor and using inositolglycan mediators as the signal transduction system. J Clin Endocrinol Metab. 1998;83(6):2001-5. DOI:10.1210/jcem.83.6.4886
19. Munir I, Yen HW, Geller DH, et al. Insulin augmentation of 17alpha-hydroxylase activity is mediated by phosphatidyl inositol 3-kinase but not extracellular signal-regulated kinase-1/2 in human ovarian theca cells. Endocrinology. 2004;145(1):175-83. DOI:10.1210/en.2003-0329
20. Zacchè MM, Caputo L, Filippis S, et al. Efficacy of myo-inositol in the treatment of cutaneous disorders in young women with polycystic ovary syndrome. Gynecol Endocrinol. 2009;25(8):508-13. DOI:10.1080/09513590903015544
21. Costantino D, Minozzi G, Minozzi E, Guaraldi C. Metabolic and hormonal effects of myo-inositol in women with polycystic ovary syndrome: a double-blind trial. Eur Rev Med Pharmacol Sci. 2009;13(2):105-10.
22. Giordano D, Corrado F, Santamaria A, et al. Effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome: a perspective, randomized, placebo-controlled study. Menopause. 2011;18(1):102-4. DOI:10.1097/gme.0b013e3181e8e1b1
23. Gordon PR, Mawhinney TP, Gilchrest BA. Inositol is a required nutrient for keratinocyte growth. J Cell Physiol. 1988;135(3):416-24. DOI:10.1002/jcp.1041350308
24. Goren I, Müller E, Schiefelbein D, et al. Akt1 controls insulin-driven VEGF biosynthesis from keratinocytes: implications for normal and diabetes-impaired skin repair in mice. J Invest Dermatol. 2009;129(3):752-64. DOI:10.1038/jid.2008.230
25. Zhao M, Song B, Pu J, et al. Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature. 2006;442(7101):457-60. DOI:10.1038/nature04925
26. Slominski A, Zbytek B, Zmijewski M, et al. Corticotropin releasing hormone and the skin. Front Biosci. 2006;11:2230-48. DOI:10.2741/1966
27. Zbytek B, Slominski AT. Corticotropin-releasing hormone induces keratinocyte differentiation in the adult human epidermis. J Cell Physiol. 2005;203(1):118-26. DOI:10.1002/jcp.20209
28. Ashrafpour H, Huang N, Neligan PC, et al. Vasodilator effect and mechanism of action of vascular endothelial growth factor in skin vasculature. Am J Physiol Heart Circ Physiol. 2004;286(3):H946-54. DOI:10.1152/ajpheart.00901.2003
29. Lo Vasco VR, Leopizzi M, Chiappetta C, et al. Expression of phosphoinositide-specific phospholipase C enzymes in human skin fibroblasts. Connect Tissue Res. 2013;54(1):1-4. DOI:10.3109/03008207.2012.712584
30. Ehrlich HP, Diez T. Role for gap junctional intercellular communications in wound repair. Wound Repair Regen. 2003;11(6):481-9. DOI:10.1046/j.1524-475x.2003.11616.x
31. Tarnow P, Cassuto J, Jönsson A, et al. Effects of D-myo-Inositol-1,2,6-triphosphate on eicosanoid formation in burned skin. J Surg Res. 1996;62(1):1-4. DOI:10.1006/jsre.1996.0163
32. Okuda Y, Sawada T, Mizutani M, et al. Restoration of myo-inositol uptake by eicosapentaenoic acid in human skin fibroblasts cultured in high-glucose medium. Life Sci. 1995;57(5):PL71-4. DOI:10.1016/0024-3205(95)00287-g
33. Buscà R, Ballotti R. Cyclic AMP a key messenger in the regulation of skin pigmentation. Pigment Cell Res. 2000;13(2):60-9. DOI:10.1034/j.1600-0749.2000.130203.x
34. Bazan HE, King WD, Rossowska M. Metabolism of phosphoinositides and inositol polyphosphates in rabbit corneal epithelium. Curr Eye Res. 1985;4(7):793-801. DOI:10.3109/02713688509020036
35. Sekulic A, Kim SY, Hostetter G, et al. Loss of inositol polyphosphate 5-phosphatase is an early event in development of cutaneous squamous cell carcinoma. Cancer Prev Res (Phila). 2010;3(10):1277-83. DOI:10.1158/1940-6207.CAPR-10-0058
36. Tarnow P, Jönsson A, Rimbäck G, Cassuto J. Increased dermal perfusion after skin burn injury by D-myo-inositol-1,2,6-trisphosphate. Burns. 1996;22(5):363-8.
DOI:10.1016/0305-4179(95)00173-5
37. Soto X, Li J, Lea R, et al. Inositol kinase and its product accelerate wound healing by modulating calcium levels, Rho GTPases, and F-actin assembly. Proc Natl Acad Sci U S A. 2013;110(27):11029-34. DOI:10.1073/pnas.1217308110
38. Wang C, Lu S, Li J, et al. Effects of dietary myo-inositol on growth, antioxidative capacity, and nonspecific immunity in skin mucus of taimen Hucho taimen fry. Fish Physiol Biochem. 2020;46(3):1011-8. DOI:10.1007/s10695-020-00766-z
39. Ma J, Feng S, Ai D, Liu Y. D-Pinitol Ameliorates Imiquimod-Induced PsoriasisLike Skin Inflammation in a Mouse Model via the NF-κB Pathway. J Environ Pathol Toxicol Oncol. 2019;38(3):285-95. DOI:10.1615/JEnvironPatholToxicolOncol.2019030782
40. Kimura M. Function and disease in manganese. Nihon Rinsho. 2016;74(7):1186-91.
41. Gromova OA, Andreeva EN, Torshin IYu, et al. A systemic biological analysis of the role of manganese in obstetrics and gynaecology: women’s reproductive health, menstrual cycle regulation and prevention of fetal malformations. Vopr ginekol akus perinatol (Gynecology, Obstetrics and Perinatology). 2020;19(1):103-13 (in Russian).
DOI:10.20953/1726-1678-2020-1-103-113
42. Kerimkulova NV, Nikiforova NV, Vladimirova IS, et al. Influence of undifferentiated connective tissue dysplasia on the outcomes of pregnancy and childbirth. comprehensive examination of pregnant women with connective tissue dysplasia using data mining methods. Country doctor. 2013;2(19):34-8 (in Russian).
43. Kerimkulova NV, Serov VN, Nikiforova NV, et al. The influence of undifferentiated connective tissue dysplasia on the outcomes of pregnancy and childbirth: clinical aspects, morphological and immunohistochemical features of the placenta. Country doctor. 2013;3(20):28-31 (in Russian).
44. Treiber N, Maity P, Singh K, et al. The role of manganese superoxide dismutase in skin aging. Dermatoendocrinol. 2012;4(3):232-5. DOI:10.4161/derm.21819
45. Parat MO, Richard MJ, Leccia MT, et al. Does manganese protect cultured human skin fibroblasts against oxidative injury by UVA, dithranol and hydrogen peroxide? Free Radic Res. 1995;23(4):339-51. DOI:10.3109/10715769509065255
46. Tenaud I, Sainte-Marie I, Jumbou O, et al. In vitro modulation of keratinocyte wound healing integrins by zinc, copper and manganese.
Br J Dermatol. 1999;140(1):26-34. DOI:10.1046/j.1365-2133.1999.02603.x
47. Chung BY, Kim HO, Park CW, et al. Relationships of Serum Homocysteine, Vitamin B12, and Folic Acid Levels with Papulopustular Rosacea Severity: A Case-Control Study. Biomed Res Int. 2022;2022:5479626. DOI:10.1155/2022/5479626
48. Steluti J, Miranda AM, De Carli E, et al. Unmetabolized folic acid is associated with TNF-α, IL-1β and IL-12 concentrations in a population exposed to mandatory food fortification with folic acid: a cross-sectional population-based study in Sao Paulo, Brazil. Eur J Nutr. 2021;60(2):1071-9. DOI:10.1007/s00394-020-02307-z
49. Zhao M, Zhou J, Chen YH, et al. Folic Acid Promotes Wound Healing in Diabetic Mice by Suppression of Oxidative Stress. J Nutr Sci Vitaminol (Tokyo). 2018;64(1):26-33. DOI:10.3177/jnsv.64.26
50. Khan S, Rahman SZ, Ahad A. Local drug delivery of folic acid promotes oral mucosal wound healing. J Dent Sci. 2021;16(1):532-3. DOI:10.1016/j.jds.2020.07.001
51. Boykin JV Jr, Hoke GD, Driscoll CR, Dharmaraj BS. High-dose folic acid and its effect on early stage diabetic foot ulcer wound healing. Wound Repair Regen. 2020;28(4):517-25. DOI:10.1111/wrr.12804
52. Fischer F, Achterberg V, März A, et al. Folic acid and creatine improve the firmness of human skin in vivo. J Cosmet Dermatol. 2011;10(1):15-23.
DOI:10.1111/j.1473-2165.2010.00543.x
53. Blackshaw S, Sawa A, Sharp AH, et al. Type 3 inositol 1,4,5-trisphosphate receptor modulates cell death. FASEB J. 2000;14(10):1375-9. DOI:10.1096/fj.14.10.1375
54. Sato-Miyaoka M, Hisatsune C, Ebisui E, et al. Regulation of hair shedding by the type 3 IP3 receptor. J Invest Dermatol. 2012;132(9):2137-47. DOI:10.1038/jid.2012.141
2. Лиманова О.А., Громова О.А., Торшин И.Ю., и др. Систематический анализ молекулярно-физиологических эффектов мио-инозитола: данные молекулярной биологии, экспериментальной и клинической медицины. Эффективная фармакотерапия. 2013;28:32-41 [Limanova OA, Gromova OA, Torshin IYu, et al. Systematic analysis of molecular mechanisms and physiological effects of myo-inositol: findings of molecular biology, experimental and clinical medicine. Effective pharmacotherapy. 2013;28:32-41 (in Russian)].
3. Claxson A, Morris C, Blake D, et al. The anti-inflammatory effects of D-myo-inositol-1.2.6-trisphosphate (PP56) on animal models of inflammation. Agents Actions. 1990;29(1-2):68-70. DOI:10.1007/BF01964724
4. Catolla-cavalcanti A. Effect of inositol on cicatrization time of burns. Minerva Med. 1955;46(80):838-40.
5. Plascencia Gómez A, Vega Memije ME, Torres Tamayo M, Rodríguez Carreón AA. Skin disorders in overweight and obese patients and relationship with insulin. Actas Dermosifiliogr. 2014;105(2):178-85. DOI:10.1016/j.ad.2013.09.008
6. Hrynyk M, Neufeld RJ. Insulin and wound healing. Burns. 2014;40(8):1433-46. DOI:10.1016/j.burns.2014.03.020
7. Liu Y, Petreaca M, Yao M, Martins-Green M. Cell and molecular mechanisms of keratinocyte function stimulated by insulin during wound healing. BMC Cell Biol. 2009;10:1. DOI:10.1186/1471-2121-10-1
8. Chen X, Liu Y, Zhang X. Topical insulin application improves healing by regulating the wound inflammatory response. Wound Repair Regen. 2012;20(3):425-34.
DOI:10.1111/j.1524-475X.2012.00792.x
9. Gauglitz GG, Toliver-Kinsky TE, Williams FN, et al. Insulin increases resistance to burn wound infection-associated sepsis. Crit Care Med. 2010;38(1):202-8. DOI:10.1097/CCM.0b013e3181b43236
10. Tuvdendorj D, Zhang XJ, Chinkes DL, et al. Intensive insulin treatment increases donor site wound protein synthesis in burn patients. Surgery. 2011;149(4):512-8. DOI:10.1016/j.surg.2010.10.021
11. Otranto M, Nascimento AP, Monte-Alto-Costa A. Insulin resistance impairs cutaneous wound healing in mice. Wound Repair Regen. 2013;21(3):464-72. DOI:10.1111/wrr.12042
12. Громова О.А., Торшин И.Ю., Уварова Е.В., и др. Систематический анализ биологических ролей и фармакологических свойств D-хироинозитола. Гинекология. 2020;22(3):21-8 [Gromova OA, Torshin IYu, Uvarova EV, et al. Systematic analysis of the biological roles and pharmacological properties of D-chiro-inositol. Gynecology. 2020;22(3):21-8 (in Russian)]. DOI:10.26442/20795696.2020.3.200210
13. Baillargeon JP, Iuorno MJ, Apridonidze T, Nestler JE. Uncoupling between insulin and release of a D-chiro-inositol-containing inositolphosphoglycan mediator of insulin action in obese women with polycystic ovary syndrome. Metab Syndr Relat Disord. 2010;8(2):127-36. DOI:10.1089/met.2009.0052
14. Croze ML, Vella RE, Pillon NJ, et al. Chronic treatment with myo-inositol reduces white adipose tissue accretion and improves insulin sensitivity in female mice. J Nutr Biochem. 2013;24(2):457-66. DOI:10.1016/j.jnutbio.2012.01.008
15. Wang JM, Qiu Y, Yang ZQ, et al. Inositol-Requiring Enzyme 1 Facilitates Diabetic Wound Healing Through Modulating MicroRNAs. Diabetes. 2017;66(1):177-92.
DOI:10.2337/db16-0052
16. Rezvani O, Shabbak E, Aslani A, et al. A randomized, double-blind, placebo-controlled trial to determine the effects of topical insulin on wound healing. Ostomy Wound Manage. 2009;55(8):22-8.
17. Januszewski M, Issat T, Jakimiuk AA, Santor-Zaczynska M. Metabolic and hormonal effects of a combined Myo-inositol and d-chiro-inositol therapy on patients with polycystic ovary syndrome. Ginekol Pol. 2019;90(1):7-10. DOI:10.5603/GP.2019.0002
18. Nestler JE, Jakubowicz DJ, de Vargas AF, et al. Insulin stimulates testosterone biosynthesis by human thecal cells from women with polycystic ovary syndrome by activating its own receptor and using inositolglycan mediators as the signal transduction system. J Clin Endocrinol Metab. 1998;83(6):2001-5. DOI:10.1210/jcem.83.6.4886
19. Munir I, Yen HW, Geller DH, et al. Insulin augmentation of 17alpha-hydroxylase activity is mediated by phosphatidyl inositol 3-kinase but not extracellular signal-regulated kinase-1/2 in human ovarian theca cells. Endocrinology. 2004;145(1):175-83. DOI:10.1210/en.2003-0329
20. Zacchè MM, Caputo L, Filippis S, et al. Efficacy of myo-inositol in the treatment of cutaneous disorders in young women with polycystic ovary syndrome. Gynecol Endocrinol. 2009;25(8):508-13. DOI:10.1080/09513590903015544
21. Costantino D, Minozzi G, Minozzi E, Guaraldi C. Metabolic and hormonal effects of myo-inositol in women with polycystic ovary syndrome: a double-blind trial. Eur Rev Med Pharmacol Sci. 2009;13(2):105-10.
22. Giordano D, Corrado F, Santamaria A, et al. Effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome: a perspective, randomized, placebo-controlled study. Menopause. 2011;18(1):102-4. DOI:10.1097/gme.0b013e3181e8e1b1
23. Gordon PR, Mawhinney TP, Gilchrest BA. Inositol is a required nutrient for keratinocyte growth. J Cell Physiol. 1988;135(3):416-24. DOI:10.1002/jcp.1041350308
24. Goren I, Müller E, Schiefelbein D, et al. Akt1 controls insulin-driven VEGF biosynthesis from keratinocytes: implications for normal and diabetes-impaired skin repair in mice. J Invest Dermatol. 2009;129(3):752-64. DOI:10.1038/jid.2008.230
25. Zhao M, Song B, Pu J, et al. Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature. 2006;442(7101):457-60. DOI:10.1038/nature04925
26. Slominski A, Zbytek B, Zmijewski M, et al. Corticotropin releasing hormone and the skin. Front Biosci. 2006;11:2230-48. DOI:10.2741/1966
27. Zbytek B, Slominski AT. Corticotropin-releasing hormone induces keratinocyte differentiation in the adult human epidermis. J Cell Physiol. 2005;203(1):118-26. DOI:10.1002/jcp.20209
28. Ashrafpour H, Huang N, Neligan PC, et al. Vasodilator effect and mechanism of action of vascular endothelial growth factor in skin vasculature. Am J Physiol Heart Circ Physiol. 2004;286(3):H946-54. DOI:10.1152/ajpheart.00901.2003
29. Lo Vasco VR, Leopizzi M, Chiappetta C, et al. Expression of phosphoinositide-specific phospholipase C enzymes in human skin fibroblasts. Connect Tissue Res. 2013;54(1):1-4. DOI:10.3109/03008207.2012.712584
30. Ehrlich HP, Diez T. Role for gap junctional intercellular communications in wound repair. Wound Repair Regen. 2003;11(6):481-9. DOI:10.1046/j.1524-475x.2003.11616.x
31. Tarnow P, Cassuto J, Jönsson A, et al. Effects of D-myo-Inositol-1,2,6-triphosphate on eicosanoid formation in burned skin. J Surg Res. 1996;62(1):1-4. DOI:10.1006/jsre.1996.0163
32. Okuda Y, Sawada T, Mizutani M, et al. Restoration of myo-inositol uptake by eicosapentaenoic acid in human skin fibroblasts cultured in high-glucose medium. Life Sci. 1995;57(5):PL71-4. DOI:10.1016/0024-3205(95)00287-g
33. Buscà R, Ballotti R. Cyclic AMP a key messenger in the regulation of skin pigmentation. Pigment Cell Res. 2000;13(2):60-9. DOI:10.1034/j.1600-0749.2000.130203.x
34. Bazan HE, King WD, Rossowska M. Metabolism of phosphoinositides and inositol polyphosphates in rabbit corneal epithelium. Curr Eye Res. 1985;4(7):793-801. DOI:10.3109/02713688509020036
35. Sekulic A, Kim SY, Hostetter G, et al. Loss of inositol polyphosphate 5-phosphatase is an early event in development of cutaneous squamous cell carcinoma. Cancer Prev Res (Phila). 2010;3(10):1277-83. DOI:10.1158/1940-6207.CAPR-10-0058
36. Tarnow P, Jönsson A, Rimbäck G, Cassuto J. Increased dermal perfusion after skin burn injury by D-myo-inositol-1,2,6-trisphosphate. Burns. 1996;22(5):363-8.
DOI:10.1016/0305-4179(95)00173-5
37. Soto X, Li J, Lea R, et al. Inositol kinase and its product accelerate wound healing by modulating calcium levels, Rho GTPases, and F-actin assembly. Proc Natl Acad Sci U S A. 2013;110(27):11029-34. DOI:10.1073/pnas.1217308110
38. Wang C, Lu S, Li J, et al. Effects of dietary myo-inositol on growth, antioxidative capacity, and nonspecific immunity in skin mucus of taimen Hucho taimen fry. Fish Physiol Biochem. 2020;46(3):1011-8. DOI:10.1007/s10695-020-00766-z
39. Ma J, Feng S, Ai D, Liu Y. D-Pinitol Ameliorates Imiquimod-Induced PsoriasisLike Skin Inflammation in a Mouse Model via the NF-κB Pathway. J Environ Pathol Toxicol Oncol. 2019;38(3):285-95. DOI:10.1615/JEnvironPatholToxicolOncol.2019030782
40. Kimura M. Function and disease in manganese. Nihon Rinsho. 2016;74(7):1186-91.
41. Громова О.А., Андреева Е.Н., Торшин И.Ю., и др. Системно-биологический анализ ролей марганца в акушерстве и гинекологии: репродуктивное здоровье женщины, регуляция менструального цикла и профилактика пороков развития плода. Вопросы гинекологии, акушерства и перинатологии. 2020;19(1):103-13 [Gromova OA, Andreeva EN, Torshin IYu, et al. A systemic biological analysis of the role of manganese in obstetrics and gynaecology: women’s reproductive health, menstrual cycle regulation and prevention of fetal malformations. Vopr ginekol akus perinatol (Gynecology, Obstetrics and Perinatology). 2020;19(1):103-13 (in Russian)]. DOI:10.20953/1726-1678-2020-1-103-113
42. Керимкулова Н.В., Никифорова Н.В., Владимирова И.С., и др. Влияние недифференцированной дисплазии соединительной ткани на исходы беременности и родов. комплексное обследование беременных с дисплазией соединительной ткани с использованием методов интеллектуального анализа данных. Земский врач. 2013;2(19):34-8 [Kerimkulova NV, Nikiforova NV, Vladimirova IS, et al. Influence of undifferentiated connective tissue dysplasia on the outcomes of pregnancy and childbirth. comprehensive examination of pregnant women with connective tissue dysplasia using data mining methods. Country doctor. 2013;2(19):34-8 (in Russian)].
43. Керимкулова Н.В., Серов В.Н., Никифорова Н.В., и др. Влияние недифференцированной дисплазии соединительной ткани на исходы беременности и родов: клинические аспекты, морфологические и иммуногистохимические особенности плаценты. Земский врач. 2013;3(20):28-31 [Kerimkulova NV, Serov VN, Nikiforova NV, et al. The influence of undifferentiated connective tissue dysplasia on the outcomes of pregnancy and childbirth: clinical aspects, morphological and immunohistochemical features of the placenta. Country doctor. 2013;3(20):28-31 (in Russian)].
44. Treiber N, Maity P, Singh K, et al. The role of manganese superoxide dismutase in skin aging. Dermatoendocrinol. 2012;4(3):232-5. DOI:10.4161/derm.21819
45. Parat MO, Richard MJ, Leccia MT, et al. Does manganese protect cultured human skin fibroblasts against oxidative injury by UVA, dithranol and hydrogen peroxide? Free Radic Res. 1995;23(4):339-51. DOI:10.3109/10715769509065255
46. Tenaud I, Sainte-Marie I, Jumbou O, et al. In vitro modulation of keratinocyte wound healing integrins by zinc, copper and manganese.
Br J Dermatol. 1999;140(1):26-34. DOI:10.1046/j.1365-2133.1999.02603.x
47. Chung BY, Kim HO, Park CW, et al. Relationships of Serum Homocysteine, Vitamin B12, and Folic Acid Levels with Papulopustular Rosacea Severity: A Case-Control Study. Biomed Res Int. 2022;2022:5479626. DOI:10.1155/2022/5479626
48. Steluti J, Miranda AM, De Carli E, et al. Unmetabolized folic acid is associated with TNF-α, IL-1β and IL-12 concentrations in a population exposed to mandatory food fortification with folic acid: a cross-sectional population-based study in Sao Paulo, Brazil. Eur J Nutr. 2021;60(2):1071-9. DOI:10.1007/s00394-020-02307-z
49. Zhao M, Zhou J, Chen YH, et al. Folic Acid Promotes Wound Healing in Diabetic Mice by Suppression of Oxidative Stress. J Nutr Sci Vitaminol (Tokyo). 2018;64(1):26-33. DOI:10.3177/jnsv.64.26
50. Khan S, Rahman SZ, Ahad A. Local drug delivery of folic acid promotes oral mucosal wound healing. J Dent Sci. 2021;16(1):532-3. DOI:10.1016/j.jds.2020.07.001
51. Boykin JV Jr, Hoke GD, Driscoll CR, Dharmaraj BS. High-dose folic acid and its effect on early stage diabetic foot ulcer wound healing. Wound Repair Regen. 2020;28(4):517-25. DOI:10.1111/wrr.12804
52. Fischer F, Achterberg V, März A, et al. Folic acid and creatine improve the firmness of human skin in vivo. J Cosmet Dermatol. 2011;10(1):15-23.
DOI:10.1111/j.1473-2165.2010.00543.x
53. Blackshaw S, Sawa A, Sharp AH, et al. Type 3 inositol 1,4,5-trisphosphate receptor modulates cell death. FASEB J. 2000;14(10):1375-9. DOI:10.1096/fj.14.10.1375
54. Sato-Miyaoka M, Hisatsune C, Ebisui E, et al. Regulation of hair shedding by the type 3 IP3 receptor. J Invest Dermatol. 2012;132(9):2137-47. DOI:10.1038/jid.2012.141
________________________________________________
2. Limanova OA, Gromova OA, Torshin IYu, et al. Systematic analysis of molecular mechanisms and physiological effects of myo-inositol: findings of molecular biology, experimental and clinical medicine. Effective pharmacotherapy. 2013;28:32-41 (in Russian).
3. Claxson A, Morris C, Blake D, et al. The anti-inflammatory effects of D-myo-inositol-1.2.6-trisphosphate (PP56) on animal models of inflammation. Agents Actions. 1990;29(1-2):68-70. DOI:10.1007/BF01964724
4. Catolla-cavalcanti A. Effect of inositol on cicatrization time of burns. Minerva Med. 1955;46(80):838-40.
5. Plascencia Gómez A, Vega Memije ME, Torres Tamayo M, Rodríguez Carreón AA. Skin disorders in overweight and obese patients and relationship with insulin. Actas Dermosifiliogr. 2014;105(2):178-85. DOI:10.1016/j.ad.2013.09.008
6. Hrynyk M, Neufeld RJ. Insulin and wound healing. Burns. 2014;40(8):1433-46. DOI:10.1016/j.burns.2014.03.020
7. Liu Y, Petreaca M, Yao M, Martins-Green M. Cell and molecular mechanisms of keratinocyte function stimulated by insulin during wound healing. BMC Cell Biol. 2009;10:1. DOI:10.1186/1471-2121-10-1
8. Chen X, Liu Y, Zhang X. Topical insulin application improves healing by regulating the wound inflammatory response. Wound Repair Regen. 2012;20(3):425-34.
DOI:10.1111/j.1524-475X.2012.00792.x
9. Gauglitz GG, Toliver-Kinsky TE, Williams FN, et al. Insulin increases resistance to burn wound infection-associated sepsis. Crit Care Med. 2010;38(1):202-8. DOI:10.1097/CCM.0b013e3181b43236
10. Tuvdendorj D, Zhang XJ, Chinkes DL, et al. Intensive insulin treatment increases donor site wound protein synthesis in burn patients. Surgery. 2011;149(4):512-8. DOI:10.1016/j.surg.2010.10.021
11. Otranto M, Nascimento AP, Monte-Alto-Costa A. Insulin resistance impairs cutaneous wound healing in mice. Wound Repair Regen. 2013;21(3):464-72. DOI:10.1111/wrr.12042
12. Gromova OA, Torshin IYu, Uvarova EV, et al. Systematic analysis of the biological roles and pharmacological properties of D-chiro-inositol. Gynecology. 2020;22(3):21-8 (in Russian). DOI:10.26442/20795696.2020.3.200210
13. Baillargeon JP, Iuorno MJ, Apridonidze T, Nestler JE. Uncoupling between insulin and release of a D-chiro-inositol-containing inositolphosphoglycan mediator of insulin action in obese women with polycystic ovary syndrome. Metab Syndr Relat Disord. 2010;8(2):127-36. DOI:10.1089/met.2009.0052
14. Croze ML, Vella RE, Pillon NJ, et al. Chronic treatment with myo-inositol reduces white adipose tissue accretion and improves insulin sensitivity in female mice. J Nutr Biochem. 2013;24(2):457-66. DOI:10.1016/j.jnutbio.2012.01.008
15. Wang JM, Qiu Y, Yang ZQ, et al. Inositol-Requiring Enzyme 1 Facilitates Diabetic Wound Healing Through Modulating MicroRNAs. Diabetes. 2017;66(1):177-92.
DOI:10.2337/db16-0052
16. Rezvani O, Shabbak E, Aslani A, et al. A randomized, double-blind, placebo-controlled trial to determine the effects of topical insulin on wound healing. Ostomy Wound Manage. 2009;55(8):22-8.
17. Januszewski M, Issat T, Jakimiuk AA, Santor-Zaczynska M. Metabolic and hormonal effects of a combined Myo-inositol and d-chiro-inositol therapy on patients with polycystic ovary syndrome. Ginekol Pol. 2019;90(1):7-10. DOI:10.5603/GP.2019.0002
18. Nestler JE, Jakubowicz DJ, de Vargas AF, et al. Insulin stimulates testosterone biosynthesis by human thecal cells from women with polycystic ovary syndrome by activating its own receptor and using inositolglycan mediators as the signal transduction system. J Clin Endocrinol Metab. 1998;83(6):2001-5. DOI:10.1210/jcem.83.6.4886
19. Munir I, Yen HW, Geller DH, et al. Insulin augmentation of 17alpha-hydroxylase activity is mediated by phosphatidyl inositol 3-kinase but not extracellular signal-regulated kinase-1/2 in human ovarian theca cells. Endocrinology. 2004;145(1):175-83. DOI:10.1210/en.2003-0329
20. Zacchè MM, Caputo L, Filippis S, et al. Efficacy of myo-inositol in the treatment of cutaneous disorders in young women with polycystic ovary syndrome. Gynecol Endocrinol. 2009;25(8):508-13. DOI:10.1080/09513590903015544
21. Costantino D, Minozzi G, Minozzi E, Guaraldi C. Metabolic and hormonal effects of myo-inositol in women with polycystic ovary syndrome: a double-blind trial. Eur Rev Med Pharmacol Sci. 2009;13(2):105-10.
22. Giordano D, Corrado F, Santamaria A, et al. Effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome: a perspective, randomized, placebo-controlled study. Menopause. 2011;18(1):102-4. DOI:10.1097/gme.0b013e3181e8e1b1
23. Gordon PR, Mawhinney TP, Gilchrest BA. Inositol is a required nutrient for keratinocyte growth. J Cell Physiol. 1988;135(3):416-24. DOI:10.1002/jcp.1041350308
24. Goren I, Müller E, Schiefelbein D, et al. Akt1 controls insulin-driven VEGF biosynthesis from keratinocytes: implications for normal and diabetes-impaired skin repair in mice. J Invest Dermatol. 2009;129(3):752-64. DOI:10.1038/jid.2008.230
25. Zhao M, Song B, Pu J, et al. Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature. 2006;442(7101):457-60. DOI:10.1038/nature04925
26. Slominski A, Zbytek B, Zmijewski M, et al. Corticotropin releasing hormone and the skin. Front Biosci. 2006;11:2230-48. DOI:10.2741/1966
27. Zbytek B, Slominski AT. Corticotropin-releasing hormone induces keratinocyte differentiation in the adult human epidermis. J Cell Physiol. 2005;203(1):118-26. DOI:10.1002/jcp.20209
28. Ashrafpour H, Huang N, Neligan PC, et al. Vasodilator effect and mechanism of action of vascular endothelial growth factor in skin vasculature. Am J Physiol Heart Circ Physiol. 2004;286(3):H946-54. DOI:10.1152/ajpheart.00901.2003
29. Lo Vasco VR, Leopizzi M, Chiappetta C, et al. Expression of phosphoinositide-specific phospholipase C enzymes in human skin fibroblasts. Connect Tissue Res. 2013;54(1):1-4. DOI:10.3109/03008207.2012.712584
30. Ehrlich HP, Diez T. Role for gap junctional intercellular communications in wound repair. Wound Repair Regen. 2003;11(6):481-9. DOI:10.1046/j.1524-475x.2003.11616.x
31. Tarnow P, Cassuto J, Jönsson A, et al. Effects of D-myo-Inositol-1,2,6-triphosphate on eicosanoid formation in burned skin. J Surg Res. 1996;62(1):1-4. DOI:10.1006/jsre.1996.0163
32. Okuda Y, Sawada T, Mizutani M, et al. Restoration of myo-inositol uptake by eicosapentaenoic acid in human skin fibroblasts cultured in high-glucose medium. Life Sci. 1995;57(5):PL71-4. DOI:10.1016/0024-3205(95)00287-g
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Авторы
О.А. Громова*1, И.Ю. Торшин1, Н.К. Тетруашвили2
1 ФГУ «Федеральный исследовательский центр "Информатика и управление"» Российской академии наук, Москва, Россия;
2 ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова» Минздрава России, Москва, Россия
*unesco.gromova@gmail.com
1 Federal Research Center “Informatics and Management”, Moscow, Russia;
2 Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia
*unesco.gromova@gmail.com
1 ФГУ «Федеральный исследовательский центр "Информатика и управление"» Российской академии наук, Москва, Россия;
2 ФГБУ «Национальный медицинский исследовательский центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова» Минздрава России, Москва, Россия
*unesco.gromova@gmail.com
________________________________________________
1 Federal Research Center “Informatics and Management”, Moscow, Russia;
2 Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia
*unesco.gromova@gmail.com
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