Экстратазовый эндометриоз: тайна «черного квадрата» или «классика во плоти»?

Оразов М.Р., Радзинский В.Е., Долгов Е.Д., Абрамашвили Ю.Г. Экстратазовый эндометриоз: тайна «черного квадрата» или «классика во плоти»? Гинекология. 2023;25(1):85–90. DOI: 10.26442/20795696.2023.1.202109

© ООО «КОНСИЛИУМ МЕДИКУМ», 2023 г.

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Orazov MR, Radzinsky VE, Dolgov ED, Abramashvili YuG. Extrapelvic endometriosis: the mystery of the "black square" or "quintessential classics"? Gynecology. 2023;25(1):85–90. DOI: 10.26442/20795696.2023.1.202109

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Аннотация

Эндометриоз по-прежнему остается одним из самых загадочных и актуальных гинекологических заболеваний. Распространенность эндометриоза неуклонно растет, несмотря на разработанные инновационные методы диагностики и лечения. Эндометриоз дефинируется как появление гетеротопического эндометрия за пределами полости матки и чаще всего затрагивает органы полости малого таза. Однако все чаще мировое медицинское сообщество актуализирует изучение экстратазового эндометриоза как уникальной нозологической единицы, имеющей свои индивидуальные патогенетические паттерны, подходы к верификации и терапевтические концепции. В статье обобщены и систематизированы накопленные к настоящему времени научные данные о патогенезе, клинических фенотипах и терапии экстратазового эндометриоза.

Ключевые слова: эндометриоз, экстратазовый эндометриоз, эндометриоз передней брюшной стенки, паховый эндометриоз, эндометриоз пупка, патогенез

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Endometriosis is still one of the most mysterious and urgent gynecological diseases. The prevalence of endometriosis is steadily increasing, despite the development of innovative methods of diagnosis and treatment. Endometriosis is the presence of a heterotopic endometrium outside the uterine cavity and most often affects the pelvic organs. However, more and more often, the world medical community actualizes the study of extrapelvic endometriosis as a unique clinical entity with specific pathogenetic patterns, approaches to verification, and therapeutic concepts. The article summarizes and systematizes the current scientific data on pathogenesis, clinical phenotypes, and therapy of extrapelvic endometriosis.

Keywords: endometriosis, extrapelvic endometriosis, anterior abdominal wall endometriosis, inguinal endometriosis, umbilical endometriosis, pathogenesis

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Список литературы

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1. Yilmaz BD, Bulun SE. Endometriosis and nuclear receptors. Hum Reprod Update. 2019;25(4):473-85.
2. Hirata T, Koga K, Osuga Y. Extra-pelvic endometriosis: a review. Reprod Med Biol. 2020;19(4):323-33.
3. Meggyesy M, Friese M, Gottschalk J, Kehler U. Case Report of Cerebellar Endometriosis. J Neurol Surg A Cent Eur Neurosurg. 2020;81(4):372-6.
4. Tong SS, Yin XY, Hu SS, et al. Case report of pulmonary endometriosis and review of the literature. J Int Med Res. 2019;47(4):1766-70.
5. McArthur GJ, Lowndes S, Meagher PJ. Endometriosis following free DIEP breast reconstruction. J Plast Reconstr Aesthet Surg. 2009;62(3):420-1.
6. Anastasiu CV, Moga MA, Neculau EA, et al. Biomarkers for the Noninvasive Diagnosis of Endometriosis: State of the Art and Future Perspectives. Int J Mol Sci. 2020;21(5):1750. DOI:10.3390/ijms21051750
7. Halme J, Hammond MG, Hulka JF, et al. Retrograde menstruation in healthy women and in patients with endometriosis. Obstet Gynecol. 1984;64(2):151-4.
8. Yovich JL, Rowlands PK, Lingham S, et al. Pathogenesis of endometriosis: Look no further than John Sampson. Reprod Biomed Online. 2020;40(1):7-11.
9. Dridi D, Chiaffarino F, Parazzini F, et al. Umbilical endometriosis: a systematic literature review and pathogenic theory proposal. J Clin Med. 2022;11(4):995.
10. Bindra V, Reddy N, Reddy CA, et al. Recurrent perineal scar endometriosis: A case report. Case Rep Womens Health. 2022:e00457.
11. Adamczyk M, Wender-Ozegowska E, Kedzia M. Epigenetic Factors in Eutopic Endometrium in Women with Endometriosis and Infertility. Int J Mol Sci. 2022;23(7):3804.
12. Li Q, Xi M, Shen F, et al. Identification of Candidate Gene Signatures and Regulatory Networks in Endometriosis and its Related Infertility by Integrated Analysis. Reprod Sci. 2022;29(2):411-26.
13. Yarahmadi G, Dehghanian M, Sandoghsaz RS, et al. Evaluation of NF1 and RASA1 gene expression in endometriosis. Eur J Obstet Gynecol Reprod Biol X. 2022;15:100152.
14. Ren Y, Wang X, Guo J, et al. CHCHD2 Regulates Mitochondrial Function and Apoptosis of Ectopic Endometrial Stromal Cells in the Pathogenesis of Endometriosis. Reprod Sci. 2022:29(8):2152-64.
15. Han SJ, Lee JE, Cho YJ, et al. Genomic Function of Estrogen Receptor β in Endometriosis. Endocrinology. 2019;160(11):2495-516.
16. McKinnon B, Mueller M, Montgomery G. Progesterone Resistance in Endometriosis: An Acquired Property? Trends Endocrinol Metab. 2018;29(8):535-48.
17. Fukui A, Mai C, Saeki S, et al. Pelvic endometriosis and natural killer cell immunity. Am J Reprod Immunol. 2021;85(4):e13342.
18. Melioli G, Semino C, Semino A, et al. Recombinant interleukin-2 corrects in vitro the immunological defect of endometriosis. Am J Reprod Immunol. 1993;30(4):218-27. DOI:10.1111/j.1600-0897.1993.tb00623
19. Smolarz B, Szyłło K, Romanowicz H. Endometriosis: epidemiology, classification, pathogenesis, treatment and genetics (review of literature). Int J Mol Sci. 2021;22(19):10554.
20. Laganà AS, Garzon S, Götte M, et al. The pathogenesis of endometriosis: molecular and cell biology insights. Int J Mol Sci. 2019;20(22):5615.
21. Aydin GA, Ayvaci H, Koc N, et al. The Relationship between Decorin and VEGF in Endometriosis. J Coll Physicians Surg Pak. 2021;31(11):1285-90. DOI:10.29271/jcpsp.2021.11.1285
22. Grigore M, Socolov D, Pavaleanu I, et al. Abdominal wall endometriosis: an update in clinical, imagistic features, and management options. Med Ultrason. 2017;19(4):430-7.
23. Cocco G, Delli Pizzi A, Scioscia M, et al. Ultrasound imaging of abdominal wall endometriosis: a pictorial review. Diagnostics. 2021;11(4):609.
24. Sachdeva G, Divyashree PS, Shailaja N. A non-classical presentation of scar endometriosis during pregnancy: Case report and review of literature. JBRA Assist Reprod. 2022;26(3):563.
25. Федеральные клинические рекомендации «Эндометриоз». М., 2020 [Federal'nyie klinicheskiie rekomendatsii “Endometrioz”. Moscow, 2020 (in Russian)].
26. Orazov MB, Radzinsky VE, Mihaleva LM, et al. Pathogenesis and pathogenetic therapy of pelvic pain caused by infiltrating endometriosis. Difficult Patient. 2021;19(2):35-41 (in Russian).
27. Orazov MR, Radzinsky VE, Orekhov RE, Tairova MB. Effectiveness of medical therapy for preventing ovarian endometriosis recurrence after surgical treatment. Voprosy ginekologii, akusherstva i perinatologii. 2022;21(3):53 (in Russian).
28. Orazov MR, Radzinsky VE, Orekhov RE. The effectiveness of therapy for endometriosis-associated pelvic pain resistant to surgical treatment. Gynecology. 2021;23(4):314-23 (in Russian). DOI:10.26442/20795696.2021.4.201097
29. Maniglio P, Ricciardi E, Meli F, et al. Complete remission of cerebral endometriosis with dienogest: a case report. Gynecol Endocrinol. 2018;34(10):837-9.
30. Yarmolinskaya MI, Denisova VM. Modern Approaches to Add-Back Therapy in Patients with Genital Endometriosis. Effektivnaia farmakoterapiia. 2015;36:24-31 (in Russian).

Авторы

М.Р. Оразов*1, В.Е. Радзинский1, Е.Д. Долгов1, Ю.Г. Абрамашвили2

1 ФГАОУ ВО «Российский университет дружбы народов», Москва, Россия;
2 Клиника «Estelife», Краснодар, Россия
*omekan@mail.ru

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Mekan R. Orazov*1, Viktor E. Radzinsky1, Evgeny D. Dolgov1, Yuliya G. Abramashvili2

1 People’s Friendship University of Russia (RUDN University), Moscow, Russia;
2 Clinic “Estelife”, Krasnodar, Russia
*omekan@mail.ru

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