Особенности диагностики синдрома поликистозных яичников

1. Patel S. Polycystic ovary syndrome (PCOS), an inflammatory, systemic, lifestyle endocrinopathy. J Steroid Biochem Mol Biol. 2018;182:27-36. DOI:10.1016/j.jsbmb.2018.04.008
2. Teede HJ, Misso ML, Costello MF, et al. International PCOS Network. Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Fertil Steril. 2018;110(3):364-79.
3. Goodman NF, Cobin RH, Futterweit W, et al. American Association of Clinical Endocrinologists (AACE); American College of Endocrinology (ACE); Androgen Excess and PCOS Society. American Association of Clinical Endocrinologists, American College Of Endocrinology, And Androgen Excess and Pcos Society Disease State Clinical Review: guide to the best practices in the evaluation and treatment of polycystic ovary syndrome – part 2. Endocr Pract. 2015;21(12):1415-26.
4. Azziz R, Carmina E, Chen Z, et al. Polycysticovarysyndrome. Nat Rev Dis Primers. 2016;2:16057. 
5. Carvalho MJ, Subtil S, Rodrigues A, et al. Controversial association between polycystic ovary syndrome and breast cancer. Eur J Obstet Gynecol Reprod Biol. 2019;243:125-32. DOI:10.1016/j.ejogrb.2019.10.011
6. Meczekalski B, Pérez-Roncero GR, López-Baena MT, et al. The polycystic ovary syndrome and gynecological cancer risk. Gynecol Endocrinol. 2020;36(4):289-93. DOI:10.1080/09513590.2020.1730794
7. Wen Y, Wu X, Peng H, et al. Breast cancer risk in patients with polycystic ovary syndrome: a Mendelian randomization analysis. Breast Cancer Res Treat. 2021;185(3):799-806. DOI:10.1007/s10549-020-05973-z
8. Spritzer PM, Barone CR, Oliveira FB. Hirsutism in Polycystic Ovary Syndrome: Pathophysiology and Management. Curr Pharm Des. 2016;22(36):5603-13.
9. Azziz R. Polycystic Ovary Syndrome. Obstet Gynecol. 2018;132(2):321-36. DOI:10.1097/AOG.0000000000002698 
10. Meier RK. Polycystic Ovary Syndrome. Nurs Clin North Am. 2018;53(3):407-20. DOI:10.1016/j.cnur.2018.04.008 
11. Bednarska S, Siejka A. The pathogenesis and treatment of polycystic ovary syndrome: What's new? Adv Clin Exp Med. 2017;26(2):359-67. DOI:10.17219/acem/59380
12. Neven ACH, Laven J, Teede HJ, Boyle JA. A Summary on Polycystic Ovary Syndrome: Diagnostic Criteria, Prevalence, Clinical Manifestations, and Management According to the Latest International Guidelines. Semin Reprod Med. 2018;36(1):5-12.
13. Escobar-Morreale HF. Polycystic ovary syndrome: definition, etiology, diagnosis and treatment. Nat Rev Endocrinol. 2018;14(5):270-84. DOI:10.1038/nrendo.2018.24
14. Zhang J, Bao Y, Zhou X, Zheng L. Polycystic ovary syndrome and mitochondrial dysfunction. Reprod Biol Endocrinol. 2019;17(1):67. DOI:10.1186/s12958-019-0509-4
15. Rothenberg SS, Beverley R, Barnard E, et al. Polycystic ovary syndrome in adolescents. Best Pract Res Clin Obstet Gynaecol. 2018;48:103-14. DOI:10.1016/j.bpobgyn.2017.08.008
16. DiVall S, Merjaneh L. Adolescent Polycystic Ovary Syndrome: An Update. Pediatr Ann. 2019;48(8):e304-10. DOI:10.3928/19382359-20190729-01
17. Bellver J, Rodríguez-Tabernero L, Robles A, et al. Group of interest in Reproductive Endocrinology (GIER) of the Spanish Fertility Society (SEF). Polycystic ovary syndrome throughout a woman's life. J Assist Reprod Genet. 2018;35(1):25-39. DOI:10.1007/s10815-017-1047-7
18. Rodriguez-Paris D, Remlinger-Molenda A, Kurzawa R, et al. Psychiatric disorders in women with polycystic ovary syndrome. Psychiatr Pol. 2019;53(4):955-66. DOI:10.12740/PP/OnlineFirst/93105
19. Ezeh U, Huang A, Landay M, Azziz R. Long-Term Response of Hirsutism and Other Hyperandrogenic Symptoms to Combination Therapy in Polycystic Ovary Syndrome. J Womens Health (Larchmt). 2018;27(7):892-902.
20. Lizneva D, Gavrilova-Jordan L, Walker W, Azziz R. Androgen excess: Investigations and management. Best Pract Res Clin Obstet Gynaecol. 2016;37:98-118.
21. Lause M, Kamboj A, Fernandez Faith E. Dermatologic manifestations of endocrine disorders. Transl Pediatr. 2017;6(4):300-12.
22. Melibary YT. Hidradenitis suppurativa in a patient with hyperandrogenism, insulin-resistance and acanthosis nigricans (HAIR-AN syndrome). Dermatol Reports. 2018;10(1):7546.
23. Keen MA, Shah IH, Sheikh G. Cutaneous Manifestations of Polycystic Ovary Syndrome: A Cross-Sectional Clinical Study. Indian Dermatol Online J. 2017;8(2):104-10.
24. Glueck CJ, Goldenberg N. Characteristics of obesity in polycystic ovary syndrome: Etiology, treatment, and genetics. Metabolism. 2019;92:108-20.
25. Pasquali R, Oriolo C. Obesity and Androgens in Women. Front Horm Res. 2019;53:120-34.
26. Zheng SH, Li XL. Visceral adiposity index as a predictor of clinical severity and therapeutic outcome of PCOS. Gynecol Endocrinol. 2016;32(3):177-83.
27. Rodgers R, Avery J, Moore V, et al. Complex diseases and co-morbidities: polycystic ovary syndrome and type 2 diabetes mellitus. Endocr Connect. 2019:EC-18-0502.R2. DOI:10.1530/EC-18-0502
28. Беленькая Л.В. Критерии ожирения в азиатской популяции. Обзор литературы. Acta Biomedica Scientifica. 2018;(3):99-102 [Belenkaya LV. Criteria of obesity for Asian population. Literature review. Acta Biomedica Scientifica. 2018;3(3):99-102 (in Russian)].
29. Osibogun O, Ogunmoroti O, Michos ED. Polycystic ovary syndrome and cardiometabolic risk: Opportunities for cardiovascular disease prevention. Trends Cardiovasc Med. 2020;30(7):399-404.
30. Papadakis G, Kandaraki E, Papalou O, et al. Is cardiovascular risk in women with PCOS a real risk? Current insights. Minerva Endocrinol. 2017;42(4):340-55.
31. Meun C, Gunning MN, Louwers YV, et al. The cardiovascular risk profile of middle-aged women with polycystic ovary syndrome. Clin Endocrinol (Oxford). 2020;92(2):150-8.
32. Delitala AP, Capobianco G, Delitala G, et al. Polycystic ovary syndrome, adipose tissue and metabolic syndrome. Arch Gynecol Obstet. 2017;296(3):405-19. 
33. Mulder CL, Lassi ZS, Grieger JA, et al. Cardio-metabolic risk factors among young infertile women: a systematic review and meta-analysis. BJOG. 2020;127(8):930-9.
34. Damone AL, Joham AE, Loxton D, et al. Depression, anxiety and perceived stress in women with and without PCOS: a community-based study. Psychol Med. 2019;49(9):1510-20.
35. Cooney LG, Dokras A. Depression and Anxiety in Polycystic Ovary Syndrome: Etiology and Treatment. Curr Psychiatry Rep. 2017;19(11):83.
36. Rodriguez-Paris D, Remlinger-Molenda A, Kurzawa R, et al. Psychiatric disorders in women with polycystic ovary syndrome. Psychiatr Pol. 2019;53(4):955-66.
37. Brutocao C, Zaiem F, Alsawas M, et al. Psychiatric disorders in women with polycystic ovary syndrome: a systematic review and meta-analysis. Endocrine. 2018;62(2):318-25. 
38. Gibson-Helm M, Teede H, Dunaif A, et al. Delayed diagnosis and a lack of information associated with dissatisfaction in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2017;102(2):604-12.
39. Dokras A, Saini S, Gibson-Helm M, et al. Gaps in knowledge among physicians regarding diagnostic criteria and management of polycystic ovary syndrome. Fertil Steril. 2017;107(6):1380-6.e1.
40. Balen AH, Morley LC, Misso M, et al. The management of anovulatory infertility in women with polycystic ovary syndrome: An analysis of the evidence to support the development of global WHO guidance. Hum Reprod Update. 2016;22(6):687-708. 
41. Tosi F. Implications of androgen assay accuracy in the phenotyping of women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2016;101(2):610-8.
42. Прилепская В.Н., Абакарова П.Р., Яроцкая Е.Л. Современная контрацепция и качество жизни женщины. Доктор.Ру. 2017;3(132):37-42 [Prilepskaya VN, Abakarova PR, Yarotskaya YeL. Modern Contraception and Women’s Quality of Life. Doctor.Ru. 2017;3(132):37-42 (in Russian)].
43. Andersen M, Glintborg D. Diagnosis and follow-up of type 2 diabetes in women with PCOS: a role for OGTT? Eur J Endocrinol. 2018;179(3):D1-14. DOI:10.1530/EJE-18-0237
44. Anagnostis P, Tarlatzis BC, Kauffman RP. Polycystic ovarian syndrome (PCOS): Long-term metabolic consequences. Metabolism. 2018;86:33-43.
45. Nolan CJ, Prentki M. Insulin resistance and insulin hypersecretion in the metabolic syndrome and type 2 diabetes: Time for a conceptual framework shift. Diab Vasc Dis Res. 2019;16(2):118-27.
46. Pelanis R, Mellembakken JR, Sundström-Poromaa I, et al. The prevalence of Type 2 diabetes is not increased in normal-weight women with PCOS. Hum Reprod. 2017;32(11):2279-86.
47. Condorelli RA, Calogero AE, Di Mauro M, La Vignera S. PCOS and diabetes mellitus: from insulin resistance to altered beta pancreatic function, a link in evolution. Gynecol Endocrinol. 2017;33(9):665-7.
48. Jeanes YM, Reeves S. Metabolic consequences of obesity and insulin resistance in polycystic ovary syndrome: diagnostic and methodological challenges. Nutr Res Rev. 2017;30(1):97-105.
49. Osibogun O, Ogunmoroti O, Michos ED. Polycystic ovary syndrome and cardiometabolic risk: Opportunities for cardiovascular disease prevention. Trends Cardiovasc Med. 2020;30(7):399-404. DOI:10.1016/j.tcm.2019.08.010
50. Zhu RY, Wong YC, Yong EL. Sonographic evaluation of polycystic ovaries. Best Pract Res Clin Obstet Gynaecol. 2016;37:25-37.
51. Peña AS, Witchel SF, Hoeger KM, et al. Adolescent polycystic ovary syndrome according to the international evidence-based guideline. BMC Med. 2020;18(1):72. DOI:10.1186/s12916-020-01516-x
52. Meier RK. Polycystic Ovary Syndrome. Nurs Clin North Am. 2018;53(3):407-20. DOI:10.1016/j.cnur.2018.04.008
53. Cooney LG, Dokras A. Beyond fertility: polycystic ovary syndrome and long-term health. Fertil Steril. 2018;110(5):794-809. DOI:10.1016/j.fertnstert.2018.08.021

________________________________________________

1. Patel S. Polycystic ovary syndrome (PCOS), an inflammatory, systemic, lifestyle endocrinopathy. J Steroid Biochem Mol Biol. 2018;182:27-36. DOI:10.1016/j.jsbmb.2018.04.008
2. Teede HJ, Misso ML, Costello MF, et al. International PCOS Network. Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Fertil Steril. 2018;110(3):364-79.
3. Goodman NF, Cobin RH, Futterweit W, et al. American Association of Clinical Endocrinologists (AACE); American College of Endocrinology (ACE); Androgen Excess and PCOS Society. American Association of Clinical Endocrinologists, American College Of Endocrinology, And Androgen Excess and Pcos Society Disease State Clinical Review: guide to the best practices in the evaluation and treatment of polycystic ovary syndrome – part 2. Endocr Pract. 2015;21(12):1415-26.
4. Azziz R, Carmina E, Chen Z, et al. Polycysticovarysyndrome. Nat Rev Dis Primers. 2016;2:16057. 
5. Carvalho MJ, Subtil S, Rodrigues A, et al. Controversial association between polycystic ovary syndrome and breast cancer. Eur J Obstet Gynecol Reprod Biol. 2019;243:125-32. DOI:10.1016/j.ejogrb.2019.10.011
6. Meczekalski B, Pérez-Roncero GR, López-Baena MT, et al. The polycystic ovary syndrome and gynecological cancer risk. Gynecol Endocrinol. 2020;36(4):289-93. DOI:10.1080/09513590.2020.1730794
7. Wen Y, Wu X, Peng H, et al. Breast cancer risk in patients with polycystic ovary syndrome: a Mendelian randomization analysis. Breast Cancer Res Treat. 2021;185(3):799-806. DOI:10.1007/s10549-020-05973-z
8. Spritzer PM, Barone CR, Oliveira FB. Hirsutism in Polycystic Ovary Syndrome: Pathophysiology and Management. Curr Pharm Des. 2016;22(36):5603-13.
9. Azziz R. Polycystic Ovary Syndrome. Obstet Gynecol. 2018;132(2):321-36. DOI:10.1097/AOG.0000000000002698 
10. Meier RK. Polycystic Ovary Syndrome. Nurs Clin North Am. 2018;53(3):407-20. DOI:10.1016/j.cnur.2018.04.008 
11. Bednarska S, Siejka A. The pathogenesis and treatment of polycystic ovary syndrome: What's new? Adv Clin Exp Med. 2017;26(2):359-67. DOI:10.17219/acem/59380
12. Neven ACH, Laven J, Teede HJ, Boyle JA. A Summary on Polycystic Ovary Syndrome: Diagnostic Criteria, Prevalence, Clinical Manifestations, and Management According to the Latest International Guidelines. Semin Reprod Med. 2018;36(1):5-12.
13. Escobar-Morreale HF. Polycystic ovary syndrome: definition, etiology, diagnosis and treatment. Nat Rev Endocrinol. 2018;14(5):270-84. DOI:10.1038/nrendo.2018.24
14. Zhang J, Bao Y, Zhou X, Zheng L. Polycystic ovary syndrome and mitochondrial dysfunction. Reprod Biol Endocrinol. 2019;17(1):67. DOI:10.1186/s12958-019-0509-4
15. Rothenberg SS, Beverley R, Barnard E, et al. Polycystic ovary syndrome in adolescents. Best Pract Res Clin Obstet Gynaecol. 2018;48:103-14. DOI:10.1016/j.bpobgyn.2017.08.008
16. DiVall S, Merjaneh L. Adolescent Polycystic Ovary Syndrome: An Update. Pediatr Ann. 2019;48(8):e304-10. DOI:10.3928/19382359-20190729-01
17. Bellver J, Rodríguez-Tabernero L, Robles A, et al. Group of interest in Reproductive Endocrinology (GIER) of the Spanish Fertility Society (SEF). Polycystic ovary syndrome throughout a woman's life. J Assist Reprod Genet. 2018;35(1):25-39. DOI:10.1007/s10815-017-1047-7
18. Rodriguez-Paris D, Remlinger-Molenda A, Kurzawa R, et al. Psychiatric disorders in women with polycystic ovary syndrome. Psychiatr Pol. 2019;53(4):955-66. DOI:10.12740/PP/OnlineFirst/93105
19. Ezeh U, Huang A, Landay M, Azziz R. Long-Term Response of Hirsutism and Other Hyperandrogenic Symptoms to Combination Therapy in Polycystic Ovary Syndrome. J Womens Health (Larchmt). 2018;27(7):892-902.
20. Lizneva D, Gavrilova-Jordan L, Walker W, Azziz R. Androgen excess: Investigations and management. Best Pract Res Clin Obstet Gynaecol. 2016;37:98-118.
21. Lause M, Kamboj A, Fernandez Faith E. Dermatologic manifestations of endocrine disorders. Transl Pediatr. 2017;6(4):300-12.
22. Melibary YT. Hidradenitis suppurativa in a patient with hyperandrogenism, insulin-resistance and acanthosis nigricans (HAIR-AN syndrome). Dermatol Reports. 2018;10(1):7546.
23. Keen MA, Shah IH, Sheikh G. Cutaneous Manifestations of Polycystic Ovary Syndrome: A Cross-Sectional Clinical Study. Indian Dermatol Online J. 2017;8(2):104-10.
24. Glueck CJ, Goldenberg N. Characteristics of obesity in polycystic ovary syndrome: Etiology, treatment, and genetics. Metabolism. 2019;92:108-20.
25. Pasquali R, Oriolo C. Obesity and Androgens in Women. Front Horm Res. 2019;53:120-34.
26. Zheng SH, Li XL. Visceral adiposity index as a predictor of clinical severity and therapeutic outcome of PCOS. Gynecol Endocrinol. 2016;32(3):177-83.
27. Rodgers R, Avery J, Moore V, et al. Complex diseases and co-morbidities: polycystic ovary syndrome and type 2 diabetes mellitus. Endocr Connect. 2019:EC-18-0502.R2. DOI:10.1530/EC-18-0502
28. Belenkaya LV. Criteria of obesity for Asian population. Literature review. Acta Biomedica Scientifica. 2018;3(3):99-102 (in Russian).
29. Osibogun O, Ogunmoroti O, Michos ED. Polycystic ovary syndrome and cardiometabolic risk: Opportunities for cardiovascular disease prevention. Trends Cardiovasc Med. 2020;30(7):399-404.
30. Papadakis G, Kandaraki E, Papalou O, et al. Is cardiovascular risk in women with PCOS a real risk? Current insights. Minerva Endocrinol. 2017;42(4):340-55.
31. Meun C, Gunning MN, Louwers YV, et al. The cardiovascular risk profile of middle-aged women with polycystic ovary syndrome. Clin Endocrinol (Oxford). 2020;92(2):150-8.
32. Delitala AP, Capobianco G, Delitala G, et al. Polycystic ovary syndrome, adipose tissue and metabolic syndrome. Arch Gynecol Obstet. 2017;296(3):405-19. 
33. Mulder CL, Lassi ZS, Grieger JA, et al. Cardio-metabolic risk factors among young infertile women: a systematic review and meta-analysis. BJOG. 2020;127(8):930-9.
34. Damone AL, Joham AE, Loxton D, et al. Depression, anxiety and perceived stress in women with and without PCOS: a community-based study. Psychol Med. 2019;49(9):1510-20.
35. Cooney LG, Dokras A. Depression and Anxiety in Polycystic Ovary Syndrome: Etiology and Treatment. Curr Psychiatry Rep. 2017;19(11):83.
36. Rodriguez-Paris D, Remlinger-Molenda A, Kurzawa R, et al. Psychiatric disorders in women with polycystic ovary syndrome. Psychiatr Pol. 2019;53(4):955-66.
37. Brutocao C, Zaiem F, Alsawas M, et al. Psychiatric disorders in women with polycystic ovary syndrome: a systematic review and meta-analysis. Endocrine. 2018;62(2):318-25. 
38. Gibson-Helm M, Teede H, Dunaif A, et al. Delayed diagnosis and a lack of information associated with dissatisfaction in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2017;102(2):604-12.
39. Dokras A, Saini S, Gibson-Helm M, et al. Gaps in knowledge among physicians regarding diagnostic criteria and management of polycystic ovary syndrome. Fertil Steril. 2017;107(6):1380-6.e1.
40. Balen AH, Morley LC, Misso M, et al. The management of anovulatory infertility in women with polycystic ovary syndrome: An analysis of the evidence to support the development of global WHO guidance. Hum Reprod Update. 2016;22(6):687-708. 
41. Tosi F. Implications of androgen assay accuracy in the phenotyping of women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2016;101(2):610-8.
42. Prilepskaya VN, Abakarova PR, Yarotskaya YeL. Modern Contraception and Women’s Quality of Life. Doctor.Ru. 2017;3(132):37-42 (in Russian).
43. Andersen M, Glintborg D. Diagnosis and follow-up of type 2 diabetes in women with PCOS: a role for OGTT? Eur J Endocrinol. 2018;179(3):D1-14. DOI:10.1530/EJE-18-0237
44. Anagnostis P, Tarlatzis BC, Kauffman RP. Polycystic ovarian syndrome (PCOS): Long-term metabolic consequences. Metabolism. 2018;86:33-43.
45. Nolan CJ, Prentki M. Insulin resistance and insulin hypersecretion in the metabolic syndrome and type 2 diabetes: Time for a conceptual framework shift. Diab Vasc Dis Res. 2019;16(2):118-27.
46. Pelanis R, Mellembakken JR, Sundström-Poromaa I, et al. The prevalence of Type 2 diabetes is not increased in normal-weight women with PCOS. Hum Reprod. 2017;32(11):2279-86.
47. Condorelli RA, Calogero AE, Di Mauro M, La Vignera S. PCOS and diabetes mellitus: from insulin resistance to altered beta pancreatic function, a link in evolution. Gynecol Endocrinol. 2017;33(9):665-7.
48. Jeanes YM, Reeves S. Metabolic consequences of obesity and insulin resistance in polycystic ovary syndrome: diagnostic and methodological challenges. Nutr Res Rev. 2017;30(1):97-105.
49. Osibogun O, Ogunmoroti O, Michos ED. Polycystic ovary syndrome and cardiometabolic risk: Opportunities for cardiovascular disease prevention. Trends Cardiovasc Med. 2020;30(7):399-404. DOI:10.1016/j.tcm.2019.08.010
50. Zhu RY, Wong YC, Yong EL. Sonographic evaluation of polycystic ovaries. Best Pract Res Clin Obstet Gynaecol. 2016;37:25-37.
51. Peña AS, Witchel SF, Hoeger KM, et al. Adolescent polycystic ovary syndrome according to the international evidence-based guideline. BMC Med. 2020;18(1):72. DOI:10.1186/s12916-020-01516-x
52. Meier RK. Polycystic Ovary Syndrome. Nurs Clin North Am. 2018;53(3):407-20. DOI:10.1016/j.cnur.2018.04.008
53. Cooney LG, Dokras A. Beyond fertility: polycystic ovary syndrome and long-term health. Fertil Steril. 2018;110(5):794-809. DOI:10.1016/j.fertnstert.2018.08.021

Е.Н. Кравченко*1, Е.Ю. Хомутова1, Э.Н. Енгуразова2 , М.С. Воронцова3

1 ФГБОУ ВО «Омский государственный медицинский университет» Минздрава России, Омск, Россия;
2 Клинико-диагностический центр «Ультрамед», Омск, Россия;
3 ООО «Многопрофильный центр современной медицины "Евромед"», Омск, Россия
*kravchenko.en@mail.ru

________________________________________________

Elena N. Kravchenko*1, Elena Yu. Khomutova1, Elmira N. Engurazova2, Maria S. Vorontsova3

1 Omsk State Medical University, Omsk, Russia;
2 Clinical and Diagnostic Center “Ultramed”, Omsk, Russia;
3 Multidisciplinary Center of Modern Medicine “Euromed”, Omsk, Russia
*kravchenko.en@mail.ru