Особенности репродуктивной функции девочек и женщин с ревматоидным артритом
Особенности репродуктивной функции девочек и женщин с ревматоидным артритом
Казакова А.В., Санталова Г.В., Карташова П.В., Порецкова Г.Ю., Дуфинец И.Е. Особенности репродуктивной функции девочек и женщин с ревматоидным артритом. Гинекология. 2024;26(1):22–27.
DOI: 10.26442/20795696.2024.1.202645
Kazakova AV, Santalova GV, Kartashova PV, Poretskova GYu, Dufinets IE. Features of the reproductive function of girls and women with rheumatoid arthritis: A review. Gynecology. 2024;26(1):22–27.
DOI: 10.26442/20795696.2024.1.202645
Особенности репродуктивной функции девочек и женщин с ревматоидным артритом
Казакова А.В., Санталова Г.В., Карташова П.В., Порецкова Г.Ю., Дуфинец И.Е. Особенности репродуктивной функции девочек и женщин с ревматоидным артритом. Гинекология. 2024;26(1):22–27.
DOI: 10.26442/20795696.2024.1.202645
Kazakova AV, Santalova GV, Kartashova PV, Poretskova GYu, Dufinets IE. Features of the reproductive function of girls and women with rheumatoid arthritis: A review. Gynecology. 2024;26(1):22–27.
DOI: 10.26442/20795696.2024.1.202645
Ревматоидный артрит – одно из наиболее часто встречаемых и тяжелых аутоиммунных заболеваний. Распространенность ревматоидного артрита среди взрослого населения в разных географических зонах мира колеблется от 0,5 до 2%. Распространенность ювенильного идиопатического артрита составляет примерно 6 на 10 тыс. детей. Заболевание у девочек встречается в 2 раза чаще, чем у мальчиков. В некоторых исследованиях продемонстрировано возможное влияние высокой кумулятивной дозы метотрексата на функцию яичников у пациенток с системной красной волчанкой, но необходимы дальнейшие исследования, чтобы подтвердить этот эффект. Анализ литературных данных позволил нам обозначить прогностически значимые факторы развития аутоиммунной овариальной недостаточности у пациенток репродуктивного возраста с ревматической патологией, отметить факт недостающих сведений о состоянии репродуктивной системы у больных женского пола с ювенильным артритом.
Rheumatoid arthritis is one of the most common and severe autoimmune diseases. The prevalence of rheumatoid arthritis among adults in different geographical areas of the world ranges from 0.5 to 2%. The prevalence of juvenile rheumatoid arthritis is approximately 6 per 10 thousand children. The disease occurs 2 times more often in girls than in boys. Some studies have demonstrated a possible effect of high cumulative doses of methotrexate on ovarian function in patients with systemic lupus erythematosus, but further studies are needed to confirm this effect. The analysis of literature data allowed us to identify prognostically significant factors in the development of autoimmune ovarian failure in patients of reproductive age with rheumatic pathology, and to note the fact that there is missing information about the state of the reproductive system in female patients with juvenile arthritis.
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