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Применение объемообразующего вещества на основе гиалуроновой кислоты при стрессовом недержании мочи у женщин
Применение объемообразующего вещества на основе гиалуроновой кислоты при стрессовом недержании мочи у женщин
Жевлакова М.М., Русина Е.И., Шелаева Е.В., Ярмолинская М.И. Применение объемообразующего вещества на основе гиалуроновой кислоты при стрессовом недержании мочи у женщин. Гинекология.
2024;26(1):59–67. DOI: 10.26442/20795696.2024.1.202623
© ООО «КОНСИЛИУМ МЕДИКУМ», 2024 г.
DOI: 10.26442/20795696.2024.1.202623
2024;26(1):59–67. DOI: 10.26442/20795696.2024.1.202623
© ООО «КОНСИЛИУМ МЕДИКУМ», 2024 г.
________________________________________________
DOI: 10.26442/20795696.2024.1.202623
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Аннотация
Введение. Парауретральное введение объемообразующих веществ у женщин – одна из малоинвазивных технологий лечения стрессового недержания мочи (СНМ). Эффективность и безопасность данного метода зависят от свойств вводимого вещества.
Цель. Оценить результаты парауретральных инъекций гиалуроновой кислоты, «сшитой» 1,4-бутандиол диглицидиловым эфиром (EsteFILL® intim), в лечении СНМ у женщин репродуктивного и перименопаузального возраста.
Материалы и методы. Обследованы 18 пациенток 45,8±5,0 года с СНМ легкой степени тяжести в сочетании с опущением половых органов 1–2-й степени. После общеклинического и специального исследований (дневники мочеиспускания, опросники Кинга и PISQ-12, кашлевой тест, комплексное уродинамическое исследование, ультразвуковое исследование уретровезикального сегмента и тазового дна с компрессионной эластографией) проведено парауретральное введение 4,0 мл препарата EsteFILL® intim. Изучены результаты терапии через 1 и 6 мес после процедуры.
Результаты. Установлено, что введение препарата способствовало увеличению жесткости парауретральных тканей в 1,5 раза в течение 6 мес после процедуры. По результатам эластографии до лечения среднее значение коэффициента деформации парауретральных тканей задней стенки проксимального отдела уретры составило 0,66±0,46 (0,42–0,91), через 1 и 6 мес – 0,99±0,45 (0,76–1,23) и 1,00±0,36 (0,78–1,22) соответственно; р=0,009 и 0,018. Эффективность препарата EsteFILL® intim в лечении легких форм СНМ у женщин через 1 и 6 мес по результатам кашлевого теста составила 88,2 и 71,4%, согласно данным дневников мочеиспускания – 88,9 и 66,7%. В течение всего периода наблюдения пациентки отмечали уменьшение степени дискомфорта из-за СНМ и улучшение качества жизни.
Заключение. Парауретральное введение препарата EsteFILL® intim способствует повышению жесткости поддерживающих структур уретры у пациенток с СНМ. Данный метод лечения СНМ эффективен для женщин репродуктивного и перименопаузального возраста с легкой степенью тяжести заболевания, не планирующих оперативное лечение, заинтересованных в достижении быстрого результата терапии и проинформированных о снижении эффекта с течением времени после процедуры.
Ключевые слова: стрессовое недержание мочи, объемообразующие вещества, гиалуроновый биополимер, EsteFILL intim
Aim. To evaluate the results of paraurethral injections of 1,4-butanediol diglycidyl ether crosslinked high-density hyaluronic acid (EsteFILL® intim) in the treatment of SUI in women of reproductive and perimenopausal age.
Materials and methods. We examined 18 patients aged 45.8±5.0 years with mild SUI in combination with grade I–II genital prolapse. After general clinical and special studies (urination diaries, King and PISQ-12 questionnaires, cough test, complex urodynamic study, urethrovesical segment and pelvic floor ultrasound with compression elastography) paraurethral injection of 4.0 ml EsteFILL® intim drug was performed. The results of therapy were studied 1 and 6 months after the procedure.
Results. It was found that the injection of the drug contributed to an increase in the stiffness of paraurethral tissues by 1.5 times within 6 months after injection. According to the results of elastography before treatment, the average value of the strain ratio of paraurethral tissues of the proximal posterior wall of the urethra was 0.66±0.46 (0.42–0.91), after 1 and 6 months – 0.99±0.45 (0.76–1.23) and 1.00±0.36 (0.78–1.22) respectively; p=0.009 and 0.018. The effectiveness of EsteFILL® intim drug in the treatment of mild SUI in women after 1 and 6 months according to the results of a cough test was 88.2 and 71.4%, according to urination diaries – 88.9 and 66.7% respectively. During the entire observation period the patients noted a decrease in the degree of discomfort due to SUI and an improvement in the quality of life.
Conclusion. Paraurethral injection of EsteFILL® intim drug helps to increase the stiffness of the urethra supporting structures in patients with SUI. This method of treating SUI is effective for women of reproductive and perimenopausal age with mild severity disease, who do not plan surgical treatment, are interested in achieving a quick result of therapy and are informed that the effect decreases over time after the procedure.
Keywords: stress urinary incontinence, bulking agents, hyaluronic biopolymer, EsteFILL intim
Цель. Оценить результаты парауретральных инъекций гиалуроновой кислоты, «сшитой» 1,4-бутандиол диглицидиловым эфиром (EsteFILL® intim), в лечении СНМ у женщин репродуктивного и перименопаузального возраста.
Материалы и методы. Обследованы 18 пациенток 45,8±5,0 года с СНМ легкой степени тяжести в сочетании с опущением половых органов 1–2-й степени. После общеклинического и специального исследований (дневники мочеиспускания, опросники Кинга и PISQ-12, кашлевой тест, комплексное уродинамическое исследование, ультразвуковое исследование уретровезикального сегмента и тазового дна с компрессионной эластографией) проведено парауретральное введение 4,0 мл препарата EsteFILL® intim. Изучены результаты терапии через 1 и 6 мес после процедуры.
Результаты. Установлено, что введение препарата способствовало увеличению жесткости парауретральных тканей в 1,5 раза в течение 6 мес после процедуры. По результатам эластографии до лечения среднее значение коэффициента деформации парауретральных тканей задней стенки проксимального отдела уретры составило 0,66±0,46 (0,42–0,91), через 1 и 6 мес – 0,99±0,45 (0,76–1,23) и 1,00±0,36 (0,78–1,22) соответственно; р=0,009 и 0,018. Эффективность препарата EsteFILL® intim в лечении легких форм СНМ у женщин через 1 и 6 мес по результатам кашлевого теста составила 88,2 и 71,4%, согласно данным дневников мочеиспускания – 88,9 и 66,7%. В течение всего периода наблюдения пациентки отмечали уменьшение степени дискомфорта из-за СНМ и улучшение качества жизни.
Заключение. Парауретральное введение препарата EsteFILL® intim способствует повышению жесткости поддерживающих структур уретры у пациенток с СНМ. Данный метод лечения СНМ эффективен для женщин репродуктивного и перименопаузального возраста с легкой степенью тяжести заболевания, не планирующих оперативное лечение, заинтересованных в достижении быстрого результата терапии и проинформированных о снижении эффекта с течением времени после процедуры.
Ключевые слова: стрессовое недержание мочи, объемообразующие вещества, гиалуроновый биополимер, EsteFILL intim
________________________________________________
Aim. To evaluate the results of paraurethral injections of 1,4-butanediol diglycidyl ether crosslinked high-density hyaluronic acid (EsteFILL® intim) in the treatment of SUI in women of reproductive and perimenopausal age.
Materials and methods. We examined 18 patients aged 45.8±5.0 years with mild SUI in combination with grade I–II genital prolapse. After general clinical and special studies (urination diaries, King and PISQ-12 questionnaires, cough test, complex urodynamic study, urethrovesical segment and pelvic floor ultrasound with compression elastography) paraurethral injection of 4.0 ml EsteFILL® intim drug was performed. The results of therapy were studied 1 and 6 months after the procedure.
Results. It was found that the injection of the drug contributed to an increase in the stiffness of paraurethral tissues by 1.5 times within 6 months after injection. According to the results of elastography before treatment, the average value of the strain ratio of paraurethral tissues of the proximal posterior wall of the urethra was 0.66±0.46 (0.42–0.91), after 1 and 6 months – 0.99±0.45 (0.76–1.23) and 1.00±0.36 (0.78–1.22) respectively; p=0.009 and 0.018. The effectiveness of EsteFILL® intim drug in the treatment of mild SUI in women after 1 and 6 months according to the results of a cough test was 88.2 and 71.4%, according to urination diaries – 88.9 and 66.7% respectively. During the entire observation period the patients noted a decrease in the degree of discomfort due to SUI and an improvement in the quality of life.
Conclusion. Paraurethral injection of EsteFILL® intim drug helps to increase the stiffness of the urethra supporting structures in patients with SUI. This method of treating SUI is effective for women of reproductive and perimenopausal age with mild severity disease, who do not plan surgical treatment, are interested in achieving a quick result of therapy and are informed that the effect decreases over time after the procedure.
Keywords: stress urinary incontinence, bulking agents, hyaluronic biopolymer, EsteFILL intim
Полный текст
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2. AlQuaiz AM, Kazi A, AlYousefi N, et al. Urinary Incontinence Affects the Quality of Life and Increases Psychological Distress and Low Self-Esteem. Healthcare (Basel). 2023;11(12). DOI:10.3390/healthcare11121772
3. Sazonova NA, Kiseleva MG, Gadzhieva ZK, Gvozdev MYu. Urinary incontinence in women and its impact on quality of life. Urology. 2022;(2):136-9 (in Russian). DOI:10.18565/urology.2022.2.136-139
4. Kirchin V, Page T, Keegan PE, et al. Urethral injection therapy for urinary incontinence in women. Cochrane Database Syst Rev. 2017;7(7):CD003881. DOI:10.1002/14651858.CD003881.pub4
5. Neimark AI, Razdorskaia MV. Nederzhanie mochi u zhenshchin. Pod red. TA Nikolaevoi. Moscow: GEOTAR-Media, 2013 (in Russian).
6. Delancey JO. Why do women have stress urinary incontinence? Neurourol Urodyn. 2010;29(Suppl. 1):S13-7. DOI:10.1002/nau.20888
7. Serati M, Braga A, Salvatore S, et al. Up-to-Date Procedures in Female Stress Urinary Incontinence Surgery: A Concise Review on Bulking Agents Procedures. Medicina (Kaunas). 2022;58(6). DOI:10.3390/medicina58060775
8. Serati M, Braga A, Caccia G, et al. TVT-O for treatment of pure urodynamic stress urinary incontinence: Efficacy and adverse effects at 13-years follow-up. Neurourol Urodyn. 2020;39(5):1423-9. DOI:10.1002/nau.24358
9. Chapple C, Dmochowski R. Particulate Versus Non-Particulate Bulking Agents In The Treatment Of Stress Urinary Incontinence. Res Rep Urol. 2019;11:299-310. DOI:10.2147/RRU.S220216
10. Tsukanov AYu, Mirzakadiev AA, Dunkurs AV. Bulking agents in case of treatment of female stress urinary incontinence. Urology Herald. 2020;8(2):99-106 (in Russian). DOI:10.21886/2308-6424-2020-8-2-99-106
11. Bezhenar VF, Arakelyan BV, Krutova VA, et al. Urethral Bulking Agents in the Treatment of Stress Urinary Incontinence. Kuban Scientific Medical Bulletin. 2019;26(4):84-93 (in Russian). DOI:10.25207/1608-6228-2019-26-4-84-93
12. Tsukanov AYu, Mirzakadiev AA, Dunkurs AV. The first experience of injecting of bulking agents in mild stress incontinence in reproductive age womens. Experimental and Сlinical Urology. 2020;12(2):158-63 (in Russian). DOI:10.29188/2222-8543-2020-12-2-158-163
13. Galeeva AG. Lokal'noe izmenenie metabolizma kozhi pri vnutridermal'nom vvedenii nestabilizirovannoi gialuronovoi kisloty v eksperimente: avtoref. dis. …kand. med. nauk. Moscow, 2017 (in Russian).
14. Fundarò SP, Salti G, Malgapo DMH, Innocenti S. The Rheology and Physicochemical Characteristics of Hyaluronic Acid Fillers: Their Clinical Implications. Int J Mol Sci. 2022;23(18). DOI:10.3390/ijms231810518
15. Chechneva MA. Ul'trazvukovaia diagnostika prolapsa genitalii i nederzhaniia mochi u zhenshchin. Pod red. VI Krasnopol'skogo. Moscow: MEDpress-inform, 2016 (in Russian).
16. Rusina EI, Zhevlakova MM, Shelayeva EV, et al. Possibilities of elastography in the diagnosis of stress urinary incontinence in women. Journal of Obstetrics And Women’s Diseases. 2023;72(5):75-88 (in Russian). DOI:10.17816/JOWD501805
17. Rusina EI, Zhevlakova MM. Remote pelvic floor muscle training in the treatment of stress urinary incontinence in women. Journal of Obstetrics And Women’s Diseases. 2023;72(3):105-15 (in Russian). DOI:10.17816/JOWD430311
18. Pivazyan L, Kasyan G, Grigoryan B, Pushkar D. Effectiveness and safety of bulking agents versus surgical methods in women with stress urinary incontinence: a systematic review and meta-analysis. Int Urogynecol J. 2022;33(4):777-87. DOI:10.1007/s00192-021-04937-1
19. Hoe V, Haller B, Yao HH, O'Connell HE. Urethral bulking agents for the treatment of stress urinary incontinence in women: A systematic review. Neurourol Urodyn. 2021;40(6):1349-88. DOI:10.1002/nau.24696
20. Itkonen Freitas AM, Mentula M, Rahkola-Soisalo P, et al. Tension-Free Vaginal Tape Surgery versus Polyacrylamide Hydrogel Injection for Primary Stress Urinary Incontinence: A Randomized Clinical Trial. J Urol. 2020;203(2):372-8. DOI:10.1097/JU.0000000000000517
21. Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240(2):205-13. DOI:10.1097/01.sla.0000133083.54934.ae
22. Rusina EI, Zhevlakova MM. Bulking agents for minimally invasive correction of stress urinary incontinence in women. Journal of Obstetrics and Women’s Diseases. 2023;72(5):75-88 (in Russian). DOI:10.17816/JOWD501805
23. Chapple CR, Haab F, Cervigni M, et al. An open, multicentre study of NASHA/Dx Gel (Zuidex) for the treatment of stress urinary incontinence. Eur Urol. 2005;48(3):488-94. DOI:10.1016/j.eururo.2005.05.007
24. Elzayat EA, Karsenty G, Bismar TA, Corcos J. Volume changes and histological response to injected dextranomer/hyaluronic acid copolymer (Zuidex) and collagen (Contigen) in rats. Int Urogynecol J Pelvic Floor Dysfunct. 2008;19(2):247-52. DOI:10.1007/s00192-007-0414-9
25. De Boulle K, Glogau R, Kono T, et al. A review of the metabolism of 1,4-butanediol diglycidyl ether-crosslinked hyaluronic acid dermal fillers. Dermatol Surg. 2013;39(12):1758-66. DOI:10.1111/dsu.12301
26. Zakirova GSh, Gubanova EI, Gladko VV, Vavilova AA. A randomized study of the safety and effectiveness of products based on stabilized hyaluronic acid for the correction of involutional changes in face and neck. Russian Journal of Skin and Venereal Diseases. 2018;21(1):53-60 (in Russian). DOI:10.18821/1560-9588-2018-21-1
27. Watad A, Quaresma M, Bragazzi NL, et al. The autoimmune/inflammatory syndrome induced by adjuvants (ASIA)/Shoenfeld's syndrome: descriptive analysis of 300 patients from the international ASIA syndrome registry. Clin Rheumatol. 2018;37(2):483-93. DOI:10.1007/s10067-017-3748-9
28. Yao F, Laudano MA, Seklehner S, et al. Image-based simulation of urethral distensibility and flow resistance as a function of pelvic floor anatomy. Neurourol Urodyn.
2015;34(7):664-8. DOI:10.1002/nau.22624
29. Urdiales-Gálvez F, Braz A, Cavallini M. Facial rejuvenation with the new hybrid filler HArmonyCa™: Clinical and aesthetic outcomes assessed by 2D and 3D photographs, ultrasound, and elastography. J Cosmet Dermatol. 2023;22(8):2186-97. DOI:10.1111/jocd.15706
30. Ageeli W, Zhang X, Ogbonnaya CN, et al. Characterisation of Collagen Re-Modelling in Localised Prostate Cancer Using Second-Generation Harmonic Imaging and Transrectal Ultrasound Shear Wave Elastography. Cancers (Basel). 2021;13(21). DOI:10.3390/cancers13215553
31. Shibata M, Ishikawa A, Ishii J, et al. Stiffness of tongue squamous cell carcinoma measured using strain elastography correlates with the amount of collagen fibers in the tumor. Oral Radiol. 2022;38(2):278-87. DOI:10.1007/s11282-021-00556-0
32. Riegler J, Labyed Y, Rosenzweig S, et al. Tumor Elastography and Its Association with Collagen and the Tumor Microenvironment. Clin Cancer Res. 2018;24(18):4455-67. DOI:10.1158/1078-0432.CCR-17-3262
33. Fan Y, Choi TH, Chung JH, et al. Hyaluronic acid-cross-linked filler stimulates collagen type 1 and elastic fiber synthesis in skin through the TGF-β/Smad signaling pathway in a nude mouse model. J Plast Reconstr Aesthet Surg. 2019;72(8):1355-62. DOI:10.1016/j.bjps.2019.03.032
34. Varì S, Minoretti P, Emanuele E. Human dermal fibroblast response to hyaluronic acid-based injectable dermal fillers: an in vitro study. Postepy Dermatol Alergol. 2022;39(6):1088-92. DOI:10.5114/ada.2022.114927
35. Itkonen Freitas AM, Mikkola TS, Rahkola-Soisalo P, et al. Quality of life and sexual function after TVT surgery versus Bulkamid injection for primary stress urinary incontinence: 1 year results from a randomized clinical trial. Int Urogynecol J. 2021;32(3):595-601. DOI:10.1007/s00192-020-04618-5
36. Harding CK, Lapitan MC, Arlandis S, et al. EAU Guidelines on Management of Non-Neurogenic Female Lower Urinary Tract Symptoms (LUTS). European Association of Urology Guidelines. 2023.
37. Capobianco G, Saderi L, Dessole F, et al. Efficacy and effectiveness of bulking agents in the treatment of stress and mixed urinary incontinence: A systematic review and meta-analysis. Maturitas. 2020;133:13-31. DOI:10.1016/j.maturitas.2019.12.007
DOI:10.1055/s-0043-115736
2. AlQuaiz AM, Kazi A, AlYousefi N, et al. Urinary Incontinence Affects the Quality of Life and Increases Psychological Distress and Low Self-Esteem. Healthcare (Basel). 2023;11(12). DOI:10.3390/healthcare11121772
3. Сазонова Н.А., Киселева М.Г., Гаджиева З.К., Гвоздев М.Ю. Недержание мочи у женщин и его влияние на качество жизни. Урология. 2022;(2):136-9 [Sazonova NA, Kiseleva MG, Gadzhieva ZK, Gvozdev MYu. Urinary incontinence in women and its impact on quality of life. Urology. 2022;(2):136-9 (in Russian)]. DOI:10.18565/urology.2022.2.136-139
4. Kirchin V, Page T, Keegan PE, et al. Urethral injection therapy for urinary incontinence in women. Cochrane Database Syst Rev. 2017;7(7):CD003881. DOI:10.1002/14651858.CD003881.pub4
5. Неймарк А.И., Раздорская М.В. Недержание мочи у женщин. Под ред. Т.А. Николаевой. М.: ГЭОТАР-Медиа, 2013 [Neimark AI, Razdorskaia MV. Nederzhanie mochi u zhenshchin. Pod red. TA Nikolaevoi. Moscow: GEOTAR-Media, 2013 (in Russian)].
6. Delancey JO. Why do women have stress urinary incontinence? Neurourol Urodyn. 2010;29(Suppl. 1):S13-7. DOI:10.1002/nau.20888
7. Serati M, Braga A, Salvatore S, et al. Up-to-Date Procedures in Female Stress Urinary Incontinence Surgery: A Concise Review on Bulking Agents Procedures. Medicina (Kaunas). 2022;58(6). DOI:10.3390/medicina58060775
8. Serati M, Braga A, Caccia G, et al. TVT-O for treatment of pure urodynamic stress urinary incontinence: Efficacy and adverse effects at 13-years follow-up. Neurourol Urodyn. 2020;39(5):1423-9. DOI:10.1002/nau.24358
9. Chapple C, Dmochowski R. Particulate Versus Non-Particulate Bulking Agents In The Treatment Of Stress Urinary Incontinence. Res Rep Urol. 2019;11:299-310. DOI:10.2147/RRU.S220216
10. Цуканов А.Ю., Мирзакадиев А.А., Дункурс А.В. Объем-образующие вещества в лечении стрессового недержания мочи у женщин. Вестник урологии. 2020;8(2):99-106 [Tsukanov AYu, Mirzakadiev AA, Dunkurs AV. Bulking agents in case of treatment of female stress urinary incontinence. Urology Herald. 2020;8(2):99-106 (in Russian)]. DOI:10.21886/2308-6424-2020-8-2-99-106
11. Беженарь В.Ф., Аракелян Б.В., Крутова В.А., и др. Применение объемообразующих веществ в лечении стрессового недержания мочи. Кубанский научный медицинский вестник. 2019;26(4):84-93 [Bezhenar VF, Arakelyan BV, Krutova VA, et al. Urethral Bulking Agents in the Treatment of Stress Urinary Incontinence. Kuban Scientific Medical Bulletin. 2019;26(4):84-93 (in Russian)]. DOI:10.25207/1608-6228-2019-26-4-84-93
12. Цуканов А.Ю., Мирзакадиев А.А., Дункурс А.В. Первый опыт инъекционного введения объем-образующих веществ при стрессовом недержании мочи легкой степени у женщин репродуктивного возраста. Экспериментальная и клиническая урология. 2020;12(2):158-63 [Tsukanov AYu, Mirzakadiev AA, Dunkurs AV. The first experience of injecting of bulking agents in mild stress incontinence in reproductive age womens. Experimental and Сlinical Urology. 2020;12(2):158-63 (in Russian)].
DOI:10.29188/2222-8543-2020-12-2-158-163
13. Галеева А.Г. Локальное изменение метаболизма кожи при внутридермальном введении нестабилизированной гиалуроновой кислоты в эксперименте: автореф. дис. … канд. мед. наук. М., 2017 [Galeeva AG. Lokal'noe izmenenie metabolizma kozhi pri vnutridermal'nom vvedenii nestabilizirovannoi gialuronovoi kisloty v eksperimente: avtoref. dis. …kand. med. nauk. Moscow, 2017 (in Russian)].
14. Fundarò SP, Salti G, Malgapo DMH, Innocenti S. The Rheology and Physicochemical Characteristics of Hyaluronic Acid Fillers: Their Clinical Implications. Int J Mol Sci. 2022;23(18). DOI:10.3390/ijms231810518
15. Чечнева М.А. Ультразвуковая диагностика пролапса гениталий и недержания мочи у женщин. Под ред. В.И. Краснопольского. М.: МЕДпресс-информ, 2016 [Chechneva MA. Ul'trazvukovaia diagnostika prolapsa genitalii i nederzhaniia mochi u zhenshchin. Pod red. VI Krasnopol'skogo. Moscow: MEDpress-inform, 2016 (in Russian)].
16. Русина Е.И., Жевлакова М.М., Шелаева Е.В. и др. Возможности эластографии в диагностике стрессового недержания мочи у женщин. Журнал акушерства и женских болезней. 2023;72(5):75-88 [Rusina EI, Zhevlakova MM, Shelayeva EV, et al. Possibilities of elastography in the diagnosis of stress urinary incontinence in women. Journal of Obstetrics And Women’s Diseases. 2023;72(5):75-88 (in Russian)]. DOI:10.17816/JOWD501805
17. Русина Е.И., Жевлакова М.М. Дистанционные тренировки мышц тазового дна в лечении стрессового недержания мочи у женщин. Журнал акушерства и женских болезней. 2023;72(3):105-15 [Rusina EI, Zhevlakova MM. Remote pelvic floor muscle training in the treatment of stress urinary incontinence in women. Journal of Obstetrics And Women’s Diseases. 2023;72(3):105-15 (in Russian)]. DOI:10.17816/JOWD430311
18. Pivazyan L, Kasyan G, Grigoryan B, Pushkar D. Effectiveness and safety of bulking agents versus surgical methods in women with stress urinary incontinence: a systematic review and meta-analysis. Int Urogynecol J. 2022;33(4):777-87. DOI:10.1007/s00192-021-04937-1
19. Hoe V, Haller B, Yao HH, O'Connell HE. Urethral bulking agents for the treatment of stress urinary incontinence in women: A systematic review. Neurourol Urodyn. 2021;40(6):1349-88. DOI:10.1002/nau.24696
20. Itkonen Freitas AM, Mentula M, Rahkola-Soisalo P, et al. Tension-Free Vaginal Tape Surgery versus Polyacrylamide Hydrogel Injection for Primary Stress Urinary Incontinence: A Randomized Clinical Trial. J Urol. 2020;203(2):372-8. DOI:10.1097/JU.0000000000000517
21. Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240(2):205-13. DOI:10.1097/01.sla.0000133083.54934.ae
22. Русина Е.И., Жевлакова М.М. Объемообразующие вещества при малоинвазивной коррекции стрессового недержания мочи у женщин. Журнал акушерства и женских болезней. 2023;72(5):75-88 [Rusina EI, Zhevlakova MM. Bulking agents for minimally invasive correction of stress urinary incontinence in women. Journal of Obstetrics and Women’s Diseases. 2023;72(5):75-88 (in Russian)]. DOI:10.17816/JOWD501805
23. Chapple CR, Haab F, Cervigni M, et al. An open, multicentre study of NASHA/Dx Gel (Zuidex) for the treatment of stress urinary incontinence. Eur Urol. 2005;48(3):488-94. DOI:10.1016/j.eururo.2005.05.007
24. Elzayat EA, Karsenty G, Bismar TA, Corcos J. Volume changes and histological response to injected dextranomer/hyaluronic acid copolymer (Zuidex) and collagen (Contigen) in rats. Int Urogynecol J Pelvic Floor Dysfunct. 2008;19(2):247-52. DOI:10.1007/s00192-007-0414-9
25. De Boulle K, Glogau R, Kono T, et al. A review of the metabolism of 1,4-butanediol diglycidyl ether-crosslinked hyaluronic acid dermal fillers. Dermatol Surg. 2013;39(12):1758-66. DOI:10.1111/dsu.12301
26. Закирова Г.Ш., Губанова Е.И., Гладько В.В., Вавилова А.А. Рандомизированное исследование безопасности и эффективности препаратов на основе стабилизированной гиалуроновой кислоты для коррекции инволюционных изменений кожи лица и шеи. Российский журнал кожных и венерических болезней. 2018;21(1):53-60 [Zakirova GSh, Gubanova EI, Gladko VV, Vavilova AA. A randomized study of the safety and effectiveness of products based on stabilized hyaluronic acid for the correction of involutional changes in face and neck. Russian Journal of Skin and Venereal Diseases. 2018;21(1):53-60 (in Russian)]. DOI:10.18821/1560-9588-2018-21-1
27. Watad A, Quaresma M, Bragazzi NL, et al. The autoimmune/inflammatory syndrome induced by adjuvants (ASIA)/Shoenfeld's syndrome: descriptive analysis of 300 patients from the international ASIA syndrome registry. Clin Rheumatol. 2018;37(2):483-93. DOI:10.1007/s10067-017-3748-9
28. Yao F, Laudano MA, Seklehner S, et al. Image-based simulation of urethral distensibility and flow resistance as a function of pelvic floor anatomy. Neurourol Urodyn.
2015;34(7):664-8. DOI:10.1002/nau.22624
29. Urdiales-Gálvez F, Braz A, Cavallini M. Facial rejuvenation with the new hybrid filler HArmonyCa™: Clinical and aesthetic outcomes assessed by 2D and 3D photographs, ultrasound, and elastography. J Cosmet Dermatol. 2023;22(8):2186-97. DOI:10.1111/jocd.15706
30. Ageeli W, Zhang X, Ogbonnaya CN, et al. Characterisation of Collagen Re-Modelling in Localised Prostate Cancer Using Second-Generation Harmonic Imaging and Transrectal Ultrasound Shear Wave Elastography. Cancers (Basel). 2021;13(21). DOI:10.3390/cancers13215553
31. Shibata M, Ishikawa A, Ishii J, et al. Stiffness of tongue squamous cell carcinoma measured using strain elastography correlates with the amount of collagen fibers in the tumor. Oral Radiol. 2022;38(2):278-87. DOI:10.1007/s11282-021-00556-0
32. Riegler J, Labyed Y, Rosenzweig S, et al. Tumor Elastography and Its Association with Collagen and the Tumor Microenvironment. Clin Cancer Res. 2018;24(18):4455-67. DOI:10.1158/1078-0432.CCR-17-3262
33. Fan Y, Choi TH, Chung JH, et al. Hyaluronic acid-cross-linked filler stimulates collagen type 1 and elastic fiber synthesis in skin through the TGF-β/Smad signaling pathway in a nude mouse model. J Plast Reconstr Aesthet Surg. 2019;72(8):1355-62. DOI:10.1016/j.bjps.2019.03.032
34. Varì S, Minoretti P, Emanuele E. Human dermal fibroblast response to hyaluronic acid-based injectable dermal fillers: an in vitro study. Postepy Dermatol Alergol. 2022;39(6):1088-92. DOI:10.5114/ada.2022.114927
35. Itkonen Freitas AM, Mikkola TS, Rahkola-Soisalo P, et al. Quality of life and sexual function after TVT surgery versus Bulkamid injection for primary stress urinary incontinence: 1 year results from a randomized clinical trial. Int Urogynecol J. 2021;32(3):595-601. DOI:10.1007/s00192-020-04618-5
36. Harding CK, Lapitan MC, Arlandis S, et al. EAU Guidelines on Management of Non-Neurogenic Female Lower Urinary Tract Symptoms (LUTS). European Association of Urology Guidelines. 2023.
37. Capobianco G, Saderi L, Dessole F, et al. Efficacy and effectiveness of bulking agents in the treatment of stress and mixed urinary incontinence: A systematic review and meta-analysis. Maturitas. 2020;133:13-31. DOI:10.1016/j.maturitas.2019.12.007
________________________________________________
DOI:10.1055/s-0043-115736
2. AlQuaiz AM, Kazi A, AlYousefi N, et al. Urinary Incontinence Affects the Quality of Life and Increases Psychological Distress and Low Self-Esteem. Healthcare (Basel). 2023;11(12). DOI:10.3390/healthcare11121772
3. Sazonova NA, Kiseleva MG, Gadzhieva ZK, Gvozdev MYu. Urinary incontinence in women and its impact on quality of life. Urology. 2022;(2):136-9 (in Russian). DOI:10.18565/urology.2022.2.136-139
4. Kirchin V, Page T, Keegan PE, et al. Urethral injection therapy for urinary incontinence in women. Cochrane Database Syst Rev. 2017;7(7):CD003881. DOI:10.1002/14651858.CD003881.pub4
5. Neimark AI, Razdorskaia MV. Nederzhanie mochi u zhenshchin. Pod red. TA Nikolaevoi. Moscow: GEOTAR-Media, 2013 (in Russian).
6. Delancey JO. Why do women have stress urinary incontinence? Neurourol Urodyn. 2010;29(Suppl. 1):S13-7. DOI:10.1002/nau.20888
7. Serati M, Braga A, Salvatore S, et al. Up-to-Date Procedures in Female Stress Urinary Incontinence Surgery: A Concise Review on Bulking Agents Procedures. Medicina (Kaunas). 2022;58(6). DOI:10.3390/medicina58060775
8. Serati M, Braga A, Caccia G, et al. TVT-O for treatment of pure urodynamic stress urinary incontinence: Efficacy and adverse effects at 13-years follow-up. Neurourol Urodyn. 2020;39(5):1423-9. DOI:10.1002/nau.24358
9. Chapple C, Dmochowski R. Particulate Versus Non-Particulate Bulking Agents In The Treatment Of Stress Urinary Incontinence. Res Rep Urol. 2019;11:299-310. DOI:10.2147/RRU.S220216
10. Tsukanov AYu, Mirzakadiev AA, Dunkurs AV. Bulking agents in case of treatment of female stress urinary incontinence. Urology Herald. 2020;8(2):99-106 (in Russian). DOI:10.21886/2308-6424-2020-8-2-99-106
11. Bezhenar VF, Arakelyan BV, Krutova VA, et al. Urethral Bulking Agents in the Treatment of Stress Urinary Incontinence. Kuban Scientific Medical Bulletin. 2019;26(4):84-93 (in Russian). DOI:10.25207/1608-6228-2019-26-4-84-93
12. Tsukanov AYu, Mirzakadiev AA, Dunkurs AV. The first experience of injecting of bulking agents in mild stress incontinence in reproductive age womens. Experimental and Сlinical Urology. 2020;12(2):158-63 (in Russian). DOI:10.29188/2222-8543-2020-12-2-158-163
13. Galeeva AG. Lokal'noe izmenenie metabolizma kozhi pri vnutridermal'nom vvedenii nestabilizirovannoi gialuronovoi kisloty v eksperimente: avtoref. dis. …kand. med. nauk. Moscow, 2017 (in Russian).
14. Fundarò SP, Salti G, Malgapo DMH, Innocenti S. The Rheology and Physicochemical Characteristics of Hyaluronic Acid Fillers: Their Clinical Implications. Int J Mol Sci. 2022;23(18). DOI:10.3390/ijms231810518
15. Chechneva MA. Ul'trazvukovaia diagnostika prolapsa genitalii i nederzhaniia mochi u zhenshchin. Pod red. VI Krasnopol'skogo. Moscow: MEDpress-inform, 2016 (in Russian).
16. Rusina EI, Zhevlakova MM, Shelayeva EV, et al. Possibilities of elastography in the diagnosis of stress urinary incontinence in women. Journal of Obstetrics And Women’s Diseases. 2023;72(5):75-88 (in Russian). DOI:10.17816/JOWD501805
17. Rusina EI, Zhevlakova MM. Remote pelvic floor muscle training in the treatment of stress urinary incontinence in women. Journal of Obstetrics And Women’s Diseases. 2023;72(3):105-15 (in Russian). DOI:10.17816/JOWD430311
18. Pivazyan L, Kasyan G, Grigoryan B, Pushkar D. Effectiveness and safety of bulking agents versus surgical methods in women with stress urinary incontinence: a systematic review and meta-analysis. Int Urogynecol J. 2022;33(4):777-87. DOI:10.1007/s00192-021-04937-1
19. Hoe V, Haller B, Yao HH, O'Connell HE. Urethral bulking agents for the treatment of stress urinary incontinence in women: A systematic review. Neurourol Urodyn. 2021;40(6):1349-88. DOI:10.1002/nau.24696
20. Itkonen Freitas AM, Mentula M, Rahkola-Soisalo P, et al. Tension-Free Vaginal Tape Surgery versus Polyacrylamide Hydrogel Injection for Primary Stress Urinary Incontinence: A Randomized Clinical Trial. J Urol. 2020;203(2):372-8. DOI:10.1097/JU.0000000000000517
21. Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240(2):205-13. DOI:10.1097/01.sla.0000133083.54934.ae
22. Rusina EI, Zhevlakova MM. Bulking agents for minimally invasive correction of stress urinary incontinence in women. Journal of Obstetrics and Women’s Diseases. 2023;72(5):75-88 (in Russian). DOI:10.17816/JOWD501805
23. Chapple CR, Haab F, Cervigni M, et al. An open, multicentre study of NASHA/Dx Gel (Zuidex) for the treatment of stress urinary incontinence. Eur Urol. 2005;48(3):488-94. DOI:10.1016/j.eururo.2005.05.007
24. Elzayat EA, Karsenty G, Bismar TA, Corcos J. Volume changes and histological response to injected dextranomer/hyaluronic acid copolymer (Zuidex) and collagen (Contigen) in rats. Int Urogynecol J Pelvic Floor Dysfunct. 2008;19(2):247-52. DOI:10.1007/s00192-007-0414-9
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Авторы
М.М. Жевлакова*, Е.И. Русина, Е.В. Шелаева, М.И. Ярмолинская
ФГБНУ «Научно-исследовательский институт акушерства, гинекологии и репродуктологии им. Д.О. Отта», Санкт-Петербург, Россия
*gynecologist.spb@mail.ru
Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg, Russia
*gynecologist.spb@mail.ru
ФГБНУ «Научно-исследовательский институт акушерства, гинекологии и репродуктологии им. Д.О. Отта», Санкт-Петербург, Россия
*gynecologist.spb@mail.ru
________________________________________________
Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg, Russia
*gynecologist.spb@mail.ru
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