1. Успенский Ю.П., Фоминых Ю.А. Антибиотик-ассоциированная диарея: актуальность проблемы, профилактика и терапия. Архивъ внутренней медицины. 2013; 2: 46–53.
2. Лузина Е.В., Ларева Н.В. Ассоциированная с антибиотиками диарея в клинической практике. Тер. архив. 2013; 85 (2): 85–8.
3. Alam S, Mushtaq M. Antibiotic associated diarrhea in children. Indian J Pediatr 2009; 46 (6): 491–6.
4. Starr J. Clostridium difficile associated diarrhoea: diagnosis and treatment. BMJ 2005; 331 (7515): 498–501.
5. McFarland LV. Epidemiology, risk factors and treatments for antibiotic-associated diarrhea. Dig Dis 1998; 16 (5): 292–307.
6. Mitchell DK, Van R, Mason EH et al. Prospective study of toxigenic Clostridium difficile in children given amoxicillin/clavulanate for otitis media. Pediatr Infect Dis J 1996; 15 (6): 514–9.
7. Vanderhoof JA, Whitney DB, Antonson DL et al. Lactobacillus GG in the prevention of antibiotic-associated diarrhea in children. J Pediatr 1999; 135 (5): 564–8.
8. Arvola T, Laiho K, Torkkeli S et al. Prophylactic Lactobacillus GG reduces antibiotic-associated diarrhea in children with respiratory infections: a randomized study. Pediatrics 1999; 104 (5): e64.
9. Jirapinyo P, Densupsoontorn N, Thamonsiri N, Wongarn R. Prevention of antibiotic-associated diarrhea in infants by probiotics. J Med Assoc Thai 2002; 85 (Suppl. 2): S739–42.
10. Turke D, Bernet JP, Marx J et al. Incidence and risk factors of oral antibiotic-associated diarrhea in an outpatient pediatric population. J Pediatr Gastroenterol Nutr 2003; 37: 22–6.
11. Sekhi H, Shiohara M, Matsumura T et al. Prevention of antibiotic-associated diarrhea in children by Clostridium butyricum MIYAIRI. Pediatr Int 2003; 45: 86–90.
12. Kotowska M, Albrecht P, Szajewska H. Saccharomyces boulardii in the prevention of antibiotic-associated diarrhea in children: a randomized double-blind placebo controlled trial. Aliment Pharmacol Ther 2005; 21: 583–90.
13. Damrongmanee A, Ukarapol N. Incidence of antibiotic-associated diarrhea in a pediatric ambulatory care setting. J Med Assoc Thai 2007; 90: 513–17.
14. Ruszczynski M, Radzikowski A, Szajewska H. Clinical trial: effectiveness of Lactobacillus rhamnosus (strains E/N, Oxy and Pen) in the prevention of antibiotic-associated diarrhoea in children. Aliment Pharmacol Ther 2008; 28: 154–61.
15. Bartlett JG. Clinical practice. Antibiotic-associated diarrhea. N Engl J Med 2002; 346: 334–9.
16. Корниенко Е.А. Механизмы воздействия антибиотиков на кишечник, роль Энтерола в профилактике и лечении антибиотик-ассоциированной диареи у детей. Фарматека. 2010; 2: 33–7.
17. Hogenauer C, Hammer HF, Krejs GJ, Reisinger EC. Mechanisms and management of antibiotic-associated diarrhea. Clin Infect Dis 1998; 27: 702–10.
18. Binder HJ. Role of colonic short-chain fatty acid transport in diarrhea. Ann Rev Physiol 2010; 72: 297–313.
19. Hickson M. Probiotics in the prevention of antibiotic-associated diarrhoea and Clostridium difficile infection. Therap Adv Gastroenterol 2011; 4 (3): 185–97.
20. Goossens D, Jonkers D, Stobberingh E et al. Probiotics in gastroenterology: indications and future perspectives. Scand J Gastroenterol 2003; 239: 15–23.
21. World Gastroenterology Organization. Probiotics and prebiotics: Practice Guideline 2011. URL: http://www.worldgastroenterology.org/probiotics-prebiotics.html
22. Johnston BC, Supina AL, Ospina M, Vohra S. Probiotics for the prevention of pediatric antibioticassociated diarrhea. Cochrane Database Syst Rev 2008; 2: CD004827.
23. Szajewska H, Ruszczyñski M, Radzikowski A. Probiotics in the prevention of antibiotic-associated diarrhea in children: a meta-analysis of randomized controlled trials. J Pediatr 2006; 149: 367–72.
24. Johnston BC, Supina AL, Vohra S. Probiotics for pediatric antibiotic-associated diarrhea: a metaanalysis of randomized placebo-controlled trials. CMAJ 2006; 175: 377–83.
25. Антоненко О.М. Современная пробиотическая терапия в педиатрии с позиций доказательной медицины. Cons. Med. Педиатрия. 2013; 1: 44–7.
26. de Vrese M, Marteau PR. Probiotics and prebiotics: effects on diarrhea. J Nutr 2007; 137 (3 Suppl. 2): 803S–11S.
27. Буторова Л.И., Калинин А.В. Применение энтерола в клинической практике: механизмы действия и показания. Клинические перспективы гастроэнтерологии, гепатологии. 2005; 5: 34–7. 
28. McFarland LV. Systematic review and meta-analysis of Saccharomyces boulardii in adult patients. World J Gastroenterol 2010; 16 (18): 2202–22.
29. Castagliuolo I, LaMont JT, Nikulasson ST, Pothoulakis C. Saccharomyces boulardii protease inhibits Clostridium difficile toxin A effects in the rat ileum. Infect Immun 1996; 64: 5225–32.
30. Buts JP, Dekeyser N, Stilmant C et al. Saccharomyces boulardii produces in rat small intestine a novel protein phosphatase that inhibits Escherichia coli endotoxin by dephosphorylation. Pediatr Res 2006; 60: 24–9.
31. Pothoulakis C. Review article: anti-inflammatory mechanisms of action of Saccharomyces boulardii. Aliment Pharmacol Ther 2009; 30 (8): 826–33.
32. Chen X, Kokkotou EG, Mustafa N et al. Saccharomyces boulardii inhibits ERK1/2 mitogen-activated protein kinase activation both in vitro and in vivo and protects against Clostridium difficile toxin A-induced enteritis. J Biol Chem 2006; 281: 24449–54.
33. Jahn HU, Ullrich R, Schneider T et al. Immunological and trophical effects of Saccharomyces boulardii on the small intestine in healthy human volunteers. Digestion 1996; 57: 95–104.
34. Buts JP. Twenty-five years of research on Saccharomyces boulardii trophic effects: updates and perspectives. Dig Dis Sci 2009; 54: 15–18.
35. Buts JP, De Keyser N, De Raedemaeker L. Saccharomyces boulardii enhances rat intestinal enzyme expression by endoluminal release of polyamines. Pediatr Res 1994; 36: 522–7.
36. Oirard-Pipau F, Pompei A, Schneider S et al. Intestinal microflora, short chain and cellular fatty acids, influence ofa probiotic S. boulardii. Microb Ecology Health Dis 2002; 14: 220–7.
37. Morais MB, Jacob CM. The role of probiotics and prebiotics in pediatric practice. J Pediatr 2006; 82 (Suppl. 5): S189–S197.
38. Weber TK, Polanco I. Gastrointestinal microbiota and some children diseases: a review. Gastroenterol Res Pract 2012; 2012: 676585.
39. Vandenplas Y, Brunser O, Szajewska H. Saccharomyces boulardii in childhood. Eur J Pediatr 2009; 168 (3): 253–65.

И.В.Маев, Д.Т.Дичева, Д.Н.Андреев

Кафедра пропедевтики внутренних болезней и гастроэнтерологии ГБОУ ВПО МГМСУ им. А.И.Евдокимова Минздрава РФ