Микрофлора кишечника как орган иммунитета

1. Осипов Г. Невидимый орган – микрофлора человека. URL: http://www.rusmedserv.com/microbdiag/invisibleorgan.htm#b2
2. Бельмер С.В., Малкоч А.В. Кишечная микрофлора и значение пробиотиков для ее функционирования. Лечащий врач. 2006; 4: 60–5.
3. Purchiaroni F, Tortora A, Gabrielli M et al. The role of intestinal microbiota and the immune system. Eur Rev Med Pharmacol Sci 2013; 17: 323–33.
4. Kamada N, Seo S-U, Chen GY, Núñez G. Role of the gut microbiota in immunity and inflammatory disease. Nat Rev Immunol 2013; 13: 321–35.
5. Medzhitov R, Janeway CJR. Innate immune recognition: mechanisms and pathways. Immunol Rev 2000; 173: 89–97.
6. Akira S, Hemmi H. Recognition of pathogen-associated molecular patterns by TLR family. Immunol Lett 2003; 85: 85–95.
7. Chiba Y, Shida K, Nagata S et al. Well-controlled proinflammatory cytokine responses of Peyer’s patch cells to probiotic Lactobacillus casei. Immunology 2009; 130: 352–62.
8. Galdeano CM, Perdigo G. The Probiotic Bacterium Lactobacillus casei Induces Activation of the Gut Mucosal Immune System through Innate Immunity. Clin Vaccine Immunol 2006; 13 (2): 219–26.
9. Баранов А.А., Коровина Н.А., Щербаков Э.Г. и др. Бифилиз в комплексном лечении и профилактике дисбактериоза кишечника (пособие для врачей). М., 2002.
10. Горелов А.В., Милютина Л.H., Усенко Д.В. Клинические рекомендации по диагностике и лечению острых кишечных инфекций у детей. М., 2005.
11. Горелов А.В., Плоскирева А.А. Кисломолочные продукты в питании детей первого года жизни, больных острыми кишечными инфекциями. М., 2004.
12. Грачева Н.М., Горелов А.В. Новый подход к коррекции дисбиотических нарушений. Инфекц. болезни. 2005; 3 (1): 75–7.
13. Isolauri E. Immune effects of probiotics in probiotics, other nutritional factors, and intestinal microflora. Ed. by L.Hanson, R.Yolken. Nestle Nutrition Workshop Series 1999; 42: 229–41.
14. De Simone C, Vesely B et al. The role of probiotics in modulation of the immune system in man and animals. Int J Immunother 1993; 9: 23–8.
15. Isolauri E, Joensuu J, Soumalainen H et al. Improved immunogenicity of oral DxRRV reassortant rotavirus vaccine by Lactobacillus casei GG. Vaccine 1995; 13 (3): 310–2.
16. He F, Elina T, Heikki A et al. Modulation of humoral immune response through probiotics intake. FEMS Immunol Med Microbiol 2000; 29: 47–52.
17. Mullie C, Yazourh A, Thibault H et al. Increased poliovirusspecific intestinal antibody response coincides with promotion of Bifidobacterium longum-infantis and Bifidobacterium breve in infants: a randomized, double-blind, placebo-controlled trial. Pediatr Res 2004; 56 (5): 791–5.
18. Kukkonen K, Nieminen T, Poussa T et al. Effect of probiotics on vaccine antibody responses in infancy – a randomized, double-blind, placebo-controlled trial. Pediatr Allergy Immunol 2006; 17 (6): 416–21.
19. West CE, Gothefors L, Granstrom M et al. Effects of feeding probiotics during weaning on infections and antibody responses to diphtheria, tetanus and Hib vaccines. Pediatr Allergy Immunol 2008; 19 (1): 53–60.
20. Nanno M, Kato I, Kobayashi T, Shida K. Biological effects of probiotics: what impact does Lactobacillus casei shirota have on us? Int J Immunopathol Pharmacol 2011; 24 (1): 45–50.
21. Zhu Y, Michelle Luo T, Jobin C, Young HA. Gut microbiota and probiotics in colon tumorigenesis. Cancer Lett 2011; 309: 119–2.
22. Azcarate-Peril MA, Sikes M, Bruno-Barcena JM. The intestinal microbiota, gastrointestinal environment and colorectal cancer: a putative role for probiotics in prevention of colorectal cancer? Am J Physiol Gastrointest Liver Physiol 2011; 301: 401–24.
23. Penders J, Stobberingh EE, van den Brandt PA, Thijs C. The role of the intestinal microbiota in the development of atopic disorders. Allergy 2007; 62: 1223–36.
24. Majamaa H, Isolauri E. Probiotics: a novel approach in the ma-nagement of food allergy. J Allergy Clin Immunol 1997; 99: 179–85.
25. Kalliomäki M, Salminen S, Arvilommi H et al. Probiotics in primary prevention of atopic disease: a randomised placebo controlled trial. Lancet 2001; 357: 1076–9.
26. Iebba V, Nicoletti M, Schippa S. Gut microbiota and the immune system: an intimate partnership in health and disease. Int J Immunopathol Pharmacol 2012; 25 (4): 823–33.
27. Damaskos D, Kolios G. Probiotics and prebiotics in inflammatory bowel disease: microflora ‘on the scope’ Br J Clin Pharmacol 2008; 65: 453–67.
28. Turnbaugh PJ, Backhed F, Fulton L, Gordon JI. Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell Host Microb 2008; 3: 213–23.
29. Frank DN, Stamand AL, Feldman RA et al. Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci USA 2007; 104: 13780–5.
30. Конь И.Я. Пробиотические и кисломолочные продукты в питании детей раннего возраста. Лечащий врач. 2007; 1: 8–12.
31. Кожевникова Е.Н., Усенко Д.В., Николаева С.В., Елезова Л.И. Продукты с пробиотиками – важное составляющее функционального питания. Педиатрия. Журн. им. Г.Н.Сперанского. 2012; 91 (4): 72–7.
32. Плоскирева А.А., Николаева С.В. Пробиотическая поддержка питания – современный подход детской нутрициологии. Педиатрия. Журн. им. Г.Н.Сперанского. 2011; 90 (5): 107–12.
33. Николаева С.В. Клинические эффекты использования пробиотических продуктов питания. Лечащий врач. 2012; 2: 90.
34. Weizman Z, Asli G, Alsheikh A. Effect of a probiotic infant formula on infections in child care centers: comparison of two probiotic agents. Pediatrics 2005; 115 (1): 5–9.
35. Hojsak I, Snovak N, Abdoviс S et al. Lactobacillus GG in the prevention of gastrointestinal and respiratory tract infections in children who attend day care centers: a randomized, double-blind, placebo-controlled trial. Clin Nutr 2010; 29 (3): 312–6.
36. Pedone CA, Arnaud CC Postaire ER et al. Multicentric study of the effect of milk fermented by Lactobacillus casei on the incidence of diarrhea. Int J Clin Prac 2000; 54 (9): 568–71.
37. Pedone CA, Bernabeu AO, Postaire ER et al. The effect of supplementation with milk fermented by Lactobacillus casei (strain DN-114 001) on acute diarrhoea in children attending day care centres. Int J Clin Pract 1999; 53 (3): 179–84.
38. Merenstein D, Murphy M, Fokar A et al. Use of a fermented dairy probiotic drink containing Lactobacillus casei (DN-114 001) to decrease the rate of illness in kids: the DRINK study. A patient-oriented, double-blind, cluster-randomized, placebo-controlled, clinical trial. Eur J Clin Nutr 2010; 64 (7): 669–77.
39. Parra MD, M. de Morentin BE, Cobo JM et al. Daily ingestion of fermented milk containing Lactobacillus casei DN114001 improves innate-defense capacity in healthy middle-aged people. J Physiol Biochem 2004; 60 (2): 85–91.
40. Елезова Л.И. Пробиотические продукты питания в комплексной терапии острых кишечных инфекций у детей. Автореф. дис. … канд.  мед. наук. М., 2005.

Е.Н.Кожевникова1, Л.И.Елезова2, С.В.Николаева3

1 ФГБУ НИИ общей патологии и патофизиологии РАН, Москва;
2 ФГБУЗ Центральный клинический санаторий «Малаховка» для детей с родителями ФМБА России, Московская область, пос. Малаховка;
3 ФБУН Центральный НИИ эпидемиологии Роспотребнадзора, Москва