Нарушения полового созревания (пубертата) у мальчиков как отражение недиагностированных системных гормонально-метаболических нарушений

1. Deckelbaum RJ, Williams CL. Childhood obesity: the health issue. Obes Res 2001; 9 (Suppl. 4): 239–43.
2. Kotanidou EP, Grammatikopoulou MG, Spiliotis BE et al. Ten-year obesity and overweight prevalence in Greek children: a systematic review and meta-analysis of 2001–2010 data. Hormones (Athens) 2013; 12 (4): 537–49.
3. Kelishadi R, Haghdoost AA, Sadeghirad B, Khajehkazemi R. Trend in the prevalence of obesity and overweight among Iranian children and adolescents: A systematic review and meta-analysis. Nutrition 2014; 30 (4): 393–400.
4. Jin YL, Ding LL, Yao YS et al. Obesity detection rate among primary school students in the People's Republic of China: a meta-analysis. Ther Clin Risk Manag 2013; 9: 383–90.
5. Williams AJ, Henley WE, Williams CA et al. Systematic review and meta-analysis of the association between childhood overweight and obesity and primary school diet and physical activity policies. Int J Behav Nutr Phys Act 2013; 10: 101.
6. Wang Y, Wu Y, Wilson RF et al. Childhood Obesity Prevention Programs: Comparative Effectiveness Review and Meta-Analysis [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2013 Jun.
7. Perez-Morales ME, Bacardi-Gascon M, Jimenez-Cruz A. Childhood overweight and obesity prevention interventions among Hispanic children in the United States: systematic review. Nutr Hosp 2012; 27 (5): 1415–21.
8. Kaufman FR, Shaw J. Type 2 diabetes in youth: rates, antecedents, treatment, problems and prevention. Pediatr Diabetes 2007; 8 (Suppl. 9): 4–6.
9. Martin A, Saunders DH, Shenkin SD, Sproule J. Lifestyle intervention for improving school achievement in overweight or obese children and adolescents. Cochrane Database Syst Rev 2014; 3: CD009728. [Epub ahead of print].
10. Zhang FF, Kelly MJ, Saltzman E et al. Obesity in Pediatric ALL Survivors: A Meta-Analysis. Pediatrics 2014; 133 (3): e704–15.
11. Albayrak O, Putter C, Volckmar AL et al. Common obesity risk alleles in childhood attention-deficit/hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet 2013; 162B (4): 295–305.
12. Peluchon R. Childhood obesity increases risk factors for cardiovascular disease. Soins Pediatr Pueric 2013; 270: 9.
13. Yu Z, Han S, Chu J et al. Trends in overweight and obesity among children and adolescents in China from 1981 to 2010: a meta-analysis. PLoS One 2012; 7 (12): e51949. doi: 10.1371/journal.pone.0051949
14. Papoutsakis C, Priftis KN, Drakouli M et al. Childhood overweight/obesity and asthma: is there a link? A systematic review of recent epidemiologic evidence. J Acad Nutr Diet 2013; 113 (1): 77–105.
15. Ho SY, Lai YK, Lam TH et al. Risk factors and outcomes of childhood obesity in Hong Kong: a retrospective cohort study. Hong Kong Med J 2013; 19 (Suppl. 4): 45–7.
16. Lyon CJ et al. Mini-review: adiposity, inflammation, and atherogenesis. Endocrinology 2003; 144: 2195–200.
17. Панков Ю.А. Жировая ткань как эндокринный орган, регулирующий рост, половое созревание и другие физиологические функции. Биохимия. 1999; 64: 601–9.
18. Lee MJ, Fried SK. Integration of hormonal and nutrient signals that regulate leptin synthesis and secretion. Am J Physiol Endocrinol Metab 2009; 296: E1230–E1238.
19. McConway MG, Johnson D, Kelly A et al. Differences in circulating concentrations of total, free and bound leptin relate to gender and body composition in adult humans. Ann Clin Biochem 2000; 37: 717–23.
20. Luukkaa V, Pesonen U, Huhtaniemi I et al. Inverse correlation between serum testosterone and leptin in men. J Clin Endocrinol Metab 1998; 83: 3243–6.
21. Cohen PG. Obesity in men: the hypogonadalestrogen receptor relationship and its effect on glucose homeostasis. Med Hypotheses 2008; 70: 358–60.
22. Isidori AM, Caprio M, Strollo F et al. Leptin and androgens in male obesity: evidence for leptin contribution to reduced androgen levels. J Clin Endocrinol Metab 1999; 84: 3673–80.
23. Kalyani RR, Dobs AS. Androgen deficiency, diabetes, and the metabolic syndrome in men. Curr Opin Endocrinol Diabetes Obes 2007; 14: 226–34.
24. Vermeulen A, Kaufman JM, Deslypere JP, Thomas G. Attenuated luteinizing hormone (LH) pulse amplitude but normal LH pulse frequency, and its relation to plasma androgens in hypogonadism of obese men. J Clin Endocrinol Metab 1993; 76: 1140–6.
25. Калинченко С.Ю. Шаг вперед в лечении гиперпролактинемии. М., 2010.
26. Melmed S, Casanueva FF, Hoffman AR et al. Diagnosis & Treatment of Hyperprolactinemia: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2011; 96 (2): 273–88.
27. Svartberg J, Jenssen T, Sundsfjord J. The associations of endogenous testosterone and sex hormone-binding globulin with glycosylated hemoglobin levels, in community dwelling men. The Tromso Study. Diabetes Metab. 2004; 30: 29–34.
28. Уварова Е.В., Тарусин Д.И. Пособие по обследованию состояния репродуктивной системы детей и подростков. М.: Триада-Х, 2009.
29. Мирский В.Е., Рищук С.В. Руководство по детской и подростковой андрологии. СПб: СпецЛит, 2008. 
30. Мирский В.Е., Михайличенко В.В., Заезжалкин В.В. Детская и подростковая андрология. СПб: СпецЛит, 2003.
31. Скородок Л.М., Савченко О.Н. Нарушения полового развития у мальчиков. М.: Медицина, 1984.
32. Строев Ю.И., Чурилов Л.П. Эндокринология подростков. СПб: Элби-СПБ, 2004.
33. Шабалов Н.П. Диагностика и лечение эндокринных заболеваний у детей и подростков. М.: МЕДпресс-информ, 2003.
34. Tanner JM, Brооk CG, Blackwell SP. Endocrinology of puberty. 1981.
35. Шварц Г.Я. Витамин Д и Д-гормон. М.: Анахарсис, 2005.
36. Shin YH, Shin HJ, Lee YJ. Vitamin D status and childhood health. Korean J Pediatr 2013; 56 (10): 417–23.
37. Lee DM, Tajar A, Pye SR et al. EMAS study group. Association of hypogonadism with vitamin D status: the European Male Ageing Study. Eur J Endocrinol 2012; 166: 77–85.
38. Nimptsch K, Platz EA, Willett WC, Giovannucci E. Association between plasma 25-OH vitamin D and testosterone levels in men. Clin Endocrinol 2012; 77: 106–12.
39. Pilz S, Frisch S, Koertke H et al. Effect of vitamin D supplementation on testosterone levels in men. Horm Metab Res 2011; 43: 223–5.
40. Wehr E, Pilz S, Boehm BO et al. Low free testosterone is associated with heart failure mortality in older men referred for coronary angiography. Eur J Heart Fail 2011; 13: 482–8.
41. Rojansky N, Brzezinski A, Schenker JG. Seasonality in human reproduction: an update. Human Reproduction 1992; 7: 735–45.
42. Mordan-McCombs S, Brown T, Wang WL et al. Tumor progression in the LPB-Tag transgenic model of prostate cancer is altered by vitamin D receptor and serum testosterone status. J Steroid Biochem Mol Biol 2010; 121: 368–71.
43. Wortsman J, Matsuoka LY, Chen TC et al. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutrition 2000; 72: 690–3.
44. Compston JE, Vedi S, Ledger JE et al. Vitamin D status and bone histomorphometry in gross obesity. Am J Clin Nutrition 1981; 34: 2359–63.
45. Hahn S, Haselhorst U, Tan S et al. Low serum 25-hydroxyvitamin D concentrations are associated with insulin resistance and obesity in women with polycystic ovary syndrome. Exp Clin Endocrinol Diabetes 2006; 114: 577–83.
46. Kamycheva E, Joakimsen RM, Jorde R. Intakes of calcium and vitamin D predict body mass index in the population of Northern Norway. Nutrition 2003; 133: 102–6.
47. Pittas AG, Lau J, Hu FB, Dawson-Hughes B. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab 2007; 92: 2017–29.
48. Тюзиков И.А, Калинченко С.Ю., Ворслов Л.О. Тишова Ю.А. Витамин D, мужское здоровье и мужская репродукция. Андрология и генитальная хирургия. 2013; 4: 36–44.
49. Maestro B, Davila N, Carranza MC, Calle C. Identification of a vitamin D response element in the human insulin receptor gene promoter. J Steroid Biochem Mol Biol 2003; 84: 223–30.
50. Maestro B, Molero S, Bajo S et al. Transcriptional activation of the human insulin receptor gene by 1,25-dihydroxyvitamin D(3). Cell Biochem Function 2002; 20: 227–32.
51. Walker GE, Ricotti R, Roccio M et al. Pediatric obesity and vitamin D deficiency: a proteomic approach identifies multimeric adiponectin as a key link between these conditions. PLoS One 2014; 9 (1): e83685. doi: 10.1371/journal.pone.0083685
52. Rosen CJ, Abrams SA, Aloia JF et al. IOM committee members respond to Endocrine Society vitamin D guideline. J Clin Endocrinol Metab 2012; 97 (4): 1146–52.
53. Holick MF, Binkley NC, Bischoff-Ferrari HA et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011; 96 (7): 1911–30.
54. Lunenfeld B, Mskhalaya G, Kalinchenko S, Tishova Y. Recommendations on the diagnosis, treatment and monitoring of late-onset hypogonadism in men – a suggested update. Aging Male 2013; 16 (4): 143–50.
55. Сильницкий П.А., Ворохобина Н.В., Волкова Е.А. Задержка полового развития у мальчиков и подростков. СПб: СПбМАПО, 1998.
56. Meikle AW. The interrelationships between thyroid dysfunction and hypogonadism in men and boys. Thyroid 2004; 14 (Suppl. 1): S17–25.
57. Bona G, Prodam F, Monzani A. Subclinical hypothyroidism in children: natural history and when to treat. J Clin Res Pediatr Endocrinol 2013; 5 (Suppl. 1): 23–8.
58. Mansourian AR. A review on post-puberty hypothyroidism: a glance at myxedema. Pak J Biol Sci 2010; 13 (18): 866–76.
59. Тюзиков И.А. Клинические «маски» андрогенного дефицита у мужчин в общеврачебной практике. Terra Medica Nova. 2013; 1: 49–58.
60. Калинченко С.Ю., Тюзиков И.А. Практическая андрология. М.: Практическая медицина, 2009.

И.А.Тюзиков

Российская академия естествознания, Москва; Медицинский центр «Гармония», Ярославль