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Лихорадка как отправная точка в диагностическом поиске. Выбор жаропонижающего препарата
Делягин В.М. Лихорадка как отправная точка в диагностическом поиске. Выбор жаропонижающего препарата. Consilium Medicum. Педиатрия (Прил.). 2015; 1: 80–85.
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Delyagin V.M. Fever as a starting point in the diagnostic search. The choice of antipyretic drugs. Consilium Medicum. Pediatrics (Suppl.).2015; 1: 80–85.
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Аннотация
Повышение температуры – естественная физиологическая реакция на воспаление. В практике педиатра это чаще всего респираторные вирусные инфекции. Задача врача – провести своевременную дифференциальную диагностику и выбрать оптимальные схемы симптоматического и при необходимости этиопатогенетического лечения. В качестве жаропонижающего средства препаратом выбора является ибупрофен. Препарат отличается высоким профилем эффективности и безопасности, скоростью наступления и длительностью эффекта. Выбор дополнительно обосновывают наличие различных лекарственных форм препарата и возможность применения у детей с атопией.
Ключевые слова: лихорадка, аллергические заболевания, ибупрофен, парацетамол.
Ключевые слова: лихорадка, аллергические заболевания, ибупрофен, парацетамол.
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An increase in temperature – a natural physiological response to inflammation. In pediatric practice is often a viral respiratory infection. The doctor's task – to conduct timely differential diagnosis and to choose the optimal scheme of symptomatic and, if necessary, etiopathogenetic treatment. As an antipyretic drug of choice is ibuprofen. The drug has a rapid, efficient and long-lasting effect. Selecting further substantiate the existence of various dosage forms of the drug and the possibility of use in children with atopy.
Key words: fever, allergic diseases, ibuprofen, paracetamol.
Полный текст
Список литературы
1. Luszczak M. Evaluation and management of infants and young children with fever. Am Fam Physician 2001; 64: 1219–26.
2. Hay W, Hayward A, Lewin M. (eds.) Current pediatric diagnosis and treatment. 16th ed. McGraw Hill. NY 2003; p. 237–9.
3. Green R, Allergoll D, Ktze S, Lewis H et al. Management of acute fever in children: Guideline for community healthcare providers and pharmacists. S Afr Med J 2013; 103 (12): 948–54.
4. Temperature measurements in children. http://www.cps.ca/english/ statements/CP/cp00-01.htm
5. Feverish illness in children. Assessment and initial management in children younger then 5 years. NICE clinical guideline 47 developed by the national collaborating centre for womens and children health, 2007.
6. Ferri F. Seizures Febrile. In: Ferris Clinical Adviser. Mosby 2015; p. 1062.
7. Vinh H, Parry C, Hangh V et al. Double blend comparison of ibuprofen and paracetamol for adjunctive treatment of uncomplicated typhoid fever. Pediatr Infect Dis J 2004; 23: 226–30.
8. Manley J, Taddio A. Acetaminophen and ibuprofen for prevention of adverse reaction associated with childhood immunization. Ann Pharmacother 2007; 41: 1227–32.
9. Sulvivan J, Farrar H. Clinical report – fever and antipyretic use in children. Pediatrics 2011; 127: 581–7.
10. Плоскарева А.А., Петухова Е.В. Лихорадка у детей: современный взгляд на терапевтическую тактику. Consilium Medicum. Педиатрия (Прил.). 2014; 4: 70–3. / Ploskareva A.A., Petukhova E.V. Likhoradka u detei: sovremennyi vzgliad na terapevticheskuiu taktiku. Consilium Medicum. Pediatriia (Pril.). 2014; 4: 70–3. [in Russian]
11. Учайкин В.Ф., Харламова Ф.С., Легкова Т.П. и др. Клиническая эффективность терапии Нурофеном при респираторных заболеваниях, сопровождающихся острым стенозирующим ларинготрахеитом, у детей. Педиатрия. Журн. им. Г.Н.Сперанского. 2013; 6: 94–100. / Uchaikin V.F., Kharlamova F.S., Legkova T.P. i dr. Klinicheskaia effektivnost' terapii Nurofenom pri respiratornykh zabolevaniiakh, soprovozhdaiushchikhsia ostrym stenoziruiushchim laringotrakheitom, u detei. Pediatriia. Zhurn. im. G.N.Speranskogo. 2013; 6: 94–100. [in Russian]
12. Lesko SM, Louik C, Vezina RM, Mitchell AA. Asthma morbidity after the short-term use of ibuprofen in children. Pediatrics 2002; 109 (2): e20.
13. The management of fever in young children with acute respiratory infections in developing countries. WHO/ARI/93.90. Geneva, 1993.
14. McBride JT. The association of acetaminophen and asthma prevalence and severity. Pediatrics 2011; 128 (6): 1181–5.
15. Etminan M, Sadatsafavi M, Jafari S et al. Acetaminophen use and the risk of asthma in children and adults: a systematic review and meta-analysis. Chest 2009; 136 (5): 1316–23.
16. Beasley R, Clayton T, Crane J et al. Association between paracetamol use in infancy and childhood, and risk of asthma, rhinoconjunctivitis, and eczema in children aged 6–7 years: analysis from Phase Three of the ISAAC programme. Lancet 2008; 372: 1039–48.
17. Kanabar D, Dale S, Rawat M. A review of ibuprofen and acetaminophen use in febrile children and the occurrence of asthma-related symptoms. Clin Ther 2007; 29 (12): 2123–716.
18. Шифман Е.М., Ершов А.Л. Парацетамол: терапевтическое применение и проблема острых отравлений. Общая реаниматология. 2007; 3: 1. / Shifman E.M., Ershov A.L. Paratsetamol: terapevticheskoe primenenie i problema ostrykh otravlenii. Obshchaia reanimatologiia. 2007; 3: 1. [in Russian]
19. Anderson B. Paracetamol. In: E.Jacqz-Aigrain, I.Choonara, ed. Paediatric Clin Pharmacol 2006; NY: Taylor & Francis; p. 621–7.
20. Bilenko N, Tessler H, Okbe R et al. Determinants of antipyretic misuse in children up to 5 years of age: a cross-sectional study. Clin Ther 2006; 28 (5): 783–93.
21. Ушкалова Е.А. Анальгетики-антипиретики и нестероидные противовоспалительные средства в педиатрии: соотношение польза/риск и влияние на течение аллергических заболеваний. Consilium Medicum. Педиатрия (Прил.). 2013; 3: 70–5. / Ushkalova E.A. Anal'getiki-antipiretiki i nesteroidnye protivovospalitel'nye sredstva v pediatrii: sootnoshenie pol'za/risk i vliianie na techenie allergicheskikh zabolevanii. Consilium Medicum. Pediatriia (Pril.). 2013; 3: 70–5. [in Russian]
22. Farrel S. Acetaminophen toxicity. E-Medicine. Updated: Jun 24, 2014; http://emedicine.medscape.com/article/820200-overview
23. Ушкалова Е.А. Лекарственные поражения печени. Фарматека. 2003; 10. / Ushkalova E.A. Lekarstvennye porazheniia pecheni. Farmateka. 2003; 10. [in Russian]
24. Goldfrank LR, Flomenbaum NE, Lewin NA et al. Goldfrank's Toxicologic Emergencies, 7th. McGraw-Hill, NY 2002.
25. Roche C, Ragot C, Moalic J et al. Ibuprofen can induce syndrome of inappriate diuresis in healthy young patients. Case Rep Med 2013; http://doi:10.1155/2013/167267
26. Тимченко В.Н., Павлова Е.Б. Применение ибупрофена (суппозитории ректальные) в терапии различной инфекционной патологии у детей раннего возраста. Лечащий врач. 2011; 6. / Timchenko V.N., Pavlova E.B. Primenenie ibuprofena (suppozitorii rektal'nye) v terapii razlichnoi infektsionnoi patologii u detei rannego vozrasta. Lechashchii vrach. 2011; 6. [in Russian]
27. American Academy of Pediatrics Committee on Drugs. Acetaminophen toxicity in children. Pediatrics. 2001; 108 (4): 1020–4.
28. Anderson B. Paracetamol. In: Jacqz-Aigrain E, Choonara I, editors. Paediatric Clinical Pharmacology. New York: Taylor & Francis, 2006: 621–7.
29. Osterhoudt KC, Henretig FM. Still Wary of Rectal Acetaminophen. Arch Pediatr Adolesc. Med 2009; 163 (5): 491.
30. Bilenko N, Tessler H, Okbe R et al. Determinants of antipyretic misuse in children up to 5 years of age: a cross-sectional study. Clin Ther 2006; 28 (5): 783–93.
2. Hay W, Hayward A, Lewin M. (eds.) Current pediatric diagnosis and treatment. 16th ed. McGraw Hill. NY 2003; p. 237–9.
3. Green R, Allergoll D, Ktze S, Lewis H et al. Management of acute fever in children: Guideline for community healthcare providers and pharmacists. S Afr Med J 2013; 103 (12): 948–54.
4. Temperature measurements in children. http://www.cps.ca/english/ statements/CP/cp00-01.htm
5. Feverish illness in children. Assessment and initial management in children younger then 5 years. NICE clinical guideline 47 developed by the national collaborating centre for womens and children health, 2007.
6. Ferri F. Seizures Febrile. In: Ferris Clinical Adviser. Mosby 2015; p. 1062.
7. Vinh H, Parry C, Hangh V et al. Double blend comparison of ibuprofen and paracetamol for adjunctive treatment of uncomplicated typhoid fever. Pediatr Infect Dis J 2004; 23: 226–30.
8. Manley J, Taddio A. Acetaminophen and ibuprofen for prevention of adverse reaction associated with childhood immunization. Ann Pharmacother 2007; 41: 1227–32.
9. Sulvivan J, Farrar H. Clinical report – fever and antipyretic use in children. Pediatrics 2011; 127: 581–7.
10. Плоскарева А.А., Петухова Е.В. Лихорадка у детей: современный взгляд на терапевтическую тактику. Consilium Medicum. Педиатрия (Прил.). 2014; 4: 70–3. / Ploskareva A.A., Petukhova E.V. Likhoradka u detei: sovremennyi vzgliad na terapevticheskuiu taktiku. Consilium Medicum. Pediatriia (Pril.). 2014; 4: 70–3. [in Russian]
11. Учайкин В.Ф., Харламова Ф.С., Легкова Т.П. и др. Клиническая эффективность терапии Нурофеном при респираторных заболеваниях, сопровождающихся острым стенозирующим ларинготрахеитом, у детей. Педиатрия. Журн. им. Г.Н.Сперанского. 2013; 6: 94–100. / Uchaikin V.F., Kharlamova F.S., Legkova T.P. i dr. Klinicheskaia effektivnost' terapii Nurofenom pri respiratornykh zabolevaniiakh, soprovozhdaiushchikhsia ostrym stenoziruiushchim laringotrakheitom, u detei. Pediatriia. Zhurn. im. G.N.Speranskogo. 2013; 6: 94–100. [in Russian]
12. Lesko SM, Louik C, Vezina RM, Mitchell AA. Asthma morbidity after the short-term use of ibuprofen in children. Pediatrics 2002; 109 (2): e20.
13. The management of fever in young children with acute respiratory infections in developing countries. WHO/ARI/93.90. Geneva, 1993.
14. McBride JT. The association of acetaminophen and asthma prevalence and severity. Pediatrics 2011; 128 (6): 1181–5.
15. Etminan M, Sadatsafavi M, Jafari S et al. Acetaminophen use and the risk of asthma in children and adults: a systematic review and meta-analysis. Chest 2009; 136 (5): 1316–23.
16. Beasley R, Clayton T, Crane J et al. Association between paracetamol use in infancy and childhood, and risk of asthma, rhinoconjunctivitis, and eczema in children aged 6–7 years: analysis from Phase Three of the ISAAC programme. Lancet 2008; 372: 1039–48.
17. Kanabar D, Dale S, Rawat M. A review of ibuprofen and acetaminophen use in febrile children and the occurrence of asthma-related symptoms. Clin Ther 2007; 29 (12): 2123–716.
18. Шифман Е.М., Ершов А.Л. Парацетамол: терапевтическое применение и проблема острых отравлений. Общая реаниматология. 2007; 3: 1. / Shifman E.M., Ershov A.L. Paratsetamol: terapevticheskoe primenenie i problema ostrykh otravlenii. Obshchaia reanimatologiia. 2007; 3: 1. [in Russian]
19. Anderson B. Paracetamol. In: E.Jacqz-Aigrain, I.Choonara, ed. Paediatric Clin Pharmacol 2006; NY: Taylor & Francis; p. 621–7.
20. Bilenko N, Tessler H, Okbe R et al. Determinants of antipyretic misuse in children up to 5 years of age: a cross-sectional study. Clin Ther 2006; 28 (5): 783–93.
21. Ушкалова Е.А. Анальгетики-антипиретики и нестероидные противовоспалительные средства в педиатрии: соотношение польза/риск и влияние на течение аллергических заболеваний. Consilium Medicum. Педиатрия (Прил.). 2013; 3: 70–5. / Ushkalova E.A. Anal'getiki-antipiretiki i nesteroidnye protivovospalitel'nye sredstva v pediatrii: sootnoshenie pol'za/risk i vliianie na techenie allergicheskikh zabolevanii. Consilium Medicum. Pediatriia (Pril.). 2013; 3: 70–5. [in Russian]
22. Farrel S. Acetaminophen toxicity. E-Medicine. Updated: Jun 24, 2014; http://emedicine.medscape.com/article/820200-overview
23. Ушкалова Е.А. Лекарственные поражения печени. Фарматека. 2003; 10. / Ushkalova E.A. Lekarstvennye porazheniia pecheni. Farmateka. 2003; 10. [in Russian]
24. Goldfrank LR, Flomenbaum NE, Lewin NA et al. Goldfrank's Toxicologic Emergencies, 7th. McGraw-Hill, NY 2002.
25. Roche C, Ragot C, Moalic J et al. Ibuprofen can induce syndrome of inappriate diuresis in healthy young patients. Case Rep Med 2013; http://doi:10.1155/2013/167267
26. Тимченко В.Н., Павлова Е.Б. Применение ибупрофена (суппозитории ректальные) в терапии различной инфекционной патологии у детей раннего возраста. Лечащий врач. 2011; 6. / Timchenko V.N., Pavlova E.B. Primenenie ibuprofena (suppozitorii rektal'nye) v terapii razlichnoi infektsionnoi patologii u detei rannego vozrasta. Lechashchii vrach. 2011; 6. [in Russian]
27. American Academy of Pediatrics Committee on Drugs. Acetaminophen toxicity in children. Pediatrics. 2001; 108 (4): 1020–4.
28. Anderson B. Paracetamol. In: Jacqz-Aigrain E, Choonara I, editors. Paediatric Clinical Pharmacology. New York: Taylor & Francis, 2006: 621–7.
29. Osterhoudt KC, Henretig FM. Still Wary of Rectal Acetaminophen. Arch Pediatr Adolesc. Med 2009; 163 (5): 491.
30. Bilenko N, Tessler H, Okbe R et al. Determinants of antipyretic misuse in children up to 5 years of age: a cross-sectional study. Clin Ther 2006; 28 (5): 783–93.
________________________________________________
1. Luszczak M. Evaluation and management of infants and young children with fever. Am Fam Physician 2001; 64: 1219–26.
2. Hay W, Hayward A, Lewin M. (eds.) Current pediatric diagnosis and treatment. 16th ed. McGraw Hill. NY 2003; p. 237–9.
3. Green R, Allergoll D, Ktze S, Lewis H et al. Management of acute fever in children: Guideline for community healthcare providers and pharmacists. S Afr Med J 2013; 103 (12): 948–54.
4. Temperature measurements in children. http://www.cps.ca/english/ statements/CP/cp00-01.htm
5. Feverish illness in children. Assessment and initial management in children younger then 5 years. NICE clinical guideline 47 developed by the national collaborating centre for womens and children health, 2007.
6. Ferri F. Seizures Febrile. In: Ferris Clinical Adviser. Mosby 2015; p. 1062.
7. Vinh H, Parry C, Hangh V et al. Double blend comparison of ibuprofen and paracetamol for adjunctive treatment of uncomplicated typhoid fever. Pediatr Infect Dis J 2004; 23: 226–30.
8. Manley J, Taddio A. Acetaminophen and ibuprofen for prevention of adverse reaction associated with childhood immunization. Ann Pharmacother 2007; 41: 1227–32.
9. Sulvivan J, Farrar H. Clinical report – fever and antipyretic use in children. Pediatrics 2011; 127: 581–7.
10. Ploskareva A.A., Petukhova E.V. Likhoradka u detei: sovremennyi vzgliad na terapevticheskuiu taktiku. Consilium Medicum. Pediatriia (Pril.). 2014; 4: 70–3. [in Russian]
11. Uchaikin V.F., Kharlamova F.S., Legkova T.P. i dr. Klinicheskaia effektivnost' terapii Nurofenom pri respiratornykh zabolevaniiakh, soprovozhdaiushchikhsia ostrym stenoziruiushchim laringotrakheitom, u detei. Pediatriia. Zhurn. im. G.N.Speranskogo. 2013; 6: 94–100. [in Russian]
12. Lesko SM, Louik C, Vezina RM, Mitchell AA. Asthma morbidity after the short-term use of ibuprofen in children. Pediatrics 2002; 109 (2): e20.
13. The management of fever in young children with acute respiratory infections in developing countries. WHO/ARI/93.90. Geneva, 1993.
14. McBride JT. The association of acetaminophen and asthma prevalence and severity. Pediatrics 2011; 128 (6): 1181–5.
15. Etminan M, Sadatsafavi M, Jafari S et al. Acetaminophen use and the risk of asthma in children and adults: a systematic review and meta-analysis. Chest 2009; 136 (5): 1316–23.
16. Beasley R, Clayton T, Crane J et al. Association between paracetamol use in infancy and childhood, and risk of asthma, rhinoconjunctivitis, and eczema in children aged 6–7 years: analysis from Phase Three of the ISAAC programme. Lancet 2008; 372: 1039–48.
17. Kanabar D, Dale S, Rawat M. A review of ibuprofen and acetaminophen use in febrile children and the occurrence of asthma-related symptoms. Clin Ther 2007; 29 (12): 2123–716.
18. Shifman E.M., Ershov A.L. Paratsetamol: terapevticheskoe primenenie i problema ostrykh otravlenii. Obshchaia reanimatologiia. 2007; 3: 1. [in Russian]
19. Anderson B. Paracetamol. In: E.Jacqz-Aigrain, I.Choonara, ed. Paediatric Clin Pharmacol 2006; NY: Taylor & Francis; p. 621–7.
20. Bilenko N, Tessler H, Okbe R et al. Determinants of antipyretic misuse in children up to 5 years of age: a cross-sectional study. Clin Ther 2006; 28 (5): 783–93.
21. Ushkalova E.A. Anal'getiki-antipiretiki i nesteroidnye protivovospalitel'nye sredstva v pediatrii: sootnoshenie pol'za/risk i vliianie na techenie allergicheskikh zabolevanii. Consilium Medicum. Pediatriia (Pril.). 2013; 3: 70–5. [in Russian]
22. Farrel S. Acetaminophen toxicity. E-Medicine. Updated: Jun 24, 2014; http://emedicine.medscape.com/article/820200-overview
23. Ushkalova E.A. Lekarstvennye porazheniia pecheni. Farmateka. 2003; 10. [in Russian]
24. Goldfrank LR, Flomenbaum NE, Lewin NA et al. Goldfrank's Toxicologic Emergencies, 7th. McGraw-Hill, NY 2002.
25. Roche C, Ragot C, Moalic J et al. Ibuprofen can induce syndrome of inappriate diuresis in healthy young patients. Case Rep Med 2013; http://doi:10.1155/2013/167267
26. Timchenko V.N., Pavlova E.B. Primenenie ibuprofena (suppozitorii rektal'nye) v terapii razlichnoi infektsionnoi patologii u detei rannego vozrasta. Lechashchii vrach. 2011; 6. [in Russian]
27. American Academy of Pediatrics Committee on Drugs. Acetaminophen toxicity in children. Pediatrics. 2001; 108 (4): 1020–4.
28. Anderson B. Paracetamol. In: Jacqz-Aigrain E, Choonara I, editors. Paediatric Clinical Pharmacology. New York: Taylor & Francis, 2006: 621–7.
29. Osterhoudt KC, Henretig FM. Still Wary of Rectal Acetaminophen. Arch Pediatr Adolesc. Med 2009; 163 (5): 491.
30. Bilenko N, Tessler H, Okbe R et al. Determinants of antipyretic misuse in children up to 5 years of age: a cross-sectional study. Clin Ther 2006; 28 (5): 783–93.
Авторы
В.М.Делягин*
ФГБУ Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии им. Д.Рогачева Минздрава России. 117997, Россия, Москва, ул. Саморы Машела, д. 1, ГСП-7;
ГБОУ ВПО Российский национальный исследовательский медицинский университет им. Н.И.Пирогова Минздрава России. 117997, Россия, Москва, ул. Островитянова, д. 1
*delyagin-doktor@yandex.ru
ФГБУ Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии им. Д.Рогачева Минздрава России. 117997, Россия, Москва, ул. Саморы Машела, д. 1, ГСП-7;
ГБОУ ВПО Российский национальный исследовательский медицинский университет им. Н.И.Пирогова Минздрава России. 117997, Россия, Москва, ул. Островитянова, д. 1
*delyagin-doktor@yandex.ru
________________________________________________
V.M.Delyagin*
D.Rogachev Federal Research Center of Pediatric Hematology, Oncology and Immunology of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Samory Mashela, d. 1, GSP-7;
N.I.Pirogov Medical University of the Ministry of Health of the Russian Federation. 117997, Russian Federation, Moscow, ul. Ostrovitianova, d. 1
*delyagin-doktor@yandex.ru
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