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Острое воспаление небных миндалин у детей: анализ причин заболевания и возможностей лечения
Острое воспаление небных миндалин у детей: анализ причин заболевания и возможностей лечения
Карпищенко С.А., Колесникова О.М. Острое воспаление небных миндалин у детей: причины и возможности лечения. Consilium Medicum. Педиатрия (Прил.). 2015; 1: 47–49.
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Аннотация
Лечение острого тонзиллита у детей является серьезной медицинской проблемой. Своевременная адекватная терапия позволяет предотвратить развитие хронического воспаления в миндалинах. В большинстве случаев острый тонзиллит имеет вирусное происхождение, но при длительно текущем воспалении небных миндалин присоединяется микробная флора, элиминация которой – главная задача лечения тонзиллита. Терапия цефалоспоринами III поколения оказывает хороший клинический эффект в лечении острого тонзиллита, обладая высокой чувствительностью к патогенной микрофлоре, обнаруженной в глубине небных миндалин, которая вызывает часто рецидивирующий тонзиллит.
Ключевые слова: острый тонзиллит у детей, часто рецидивирующий тонзиллит, патогенная микрофлора.
Key words: acute tonsillitis in children, often recurrent tonsillitis, pathogenic microflora.
Ключевые слова: острый тонзиллит у детей, часто рецидивирующий тонзиллит, патогенная микрофлора.
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Key words: acute tonsillitis in children, often recurrent tonsillitis, pathogenic microflora.
Полный текст
Список литературы
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2. Iqbal FR, Goh BS, Mazita A. The role of proton pump inhibitors in adenoid hypertrophy in children. Otolaryngol Head Neck Surg 2012; 147 (2): 329–34.
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2. Iqbal FR, Goh BS, Mazita A. The role of proton pump inhibitors in adenoid hypertrophy in children. Otolaryngol Head Neck Surg 2012; 147 (2): 329–34.
3. Allegrucci M et al. Phenotypic characterization of Streptococcus pneumoniae biofilm development. J Bacteriol 2006; 188 (7): 2325 –35.
4. Karpishchenko S.A., Kolesnikova O.M. Vozmozhnosti lecheniya ostroy boli v gorle. Vrach. 2014; 2: 19–23. [in Russian]
5. McIsaac WJ, Kellner JD, Aufricht P et al. Empirical validation of guidelines for the management of pharyngitis in children and adults. JAMA 2004; 291: 1587–1595. Erratum in: JAMA 2005; 294: 2700.
6. Timon CI, McAllister VA, Walsh MA, Cafferkey MT. Changes in tonsil bacteriology of recurrent acute tonsillitis: 1980 vs 1989. Respir Med 1990; 84: 395–400.
7. Kumai A, Gupta V, Chandra K et al. Clinico bacteriological evaluation of surface and core microflora in chronic tonsillitis. Indian J Otolaryngol Head Neck Surg 2005; 57 (2): 118–20.
8. Mitchelmore IJ, Reilly PG, Hay AJ, Tabaqchali S. Tonsil surface and core cultures in recurrent tonsillitis: prevalence of anaerobes and beta-lactamase producing organisms. Eur J Clin Microbiol Infect Dis 1994; 13 (7): 542–8.
9. Zhuravlev A.S. Mikrobiologicheskoe obosnovanie effektivnosti razlichnykh sposobov lecheniya bol'nykh s khronicheskim kompensirovannym tonzillitom. Folia Otorhinolaryngologica 2014; 20 (1): 42–8. [in Russian]
10. Brook I, Shah K, Jackson W. Microbiology of healthy and diseased adenoids. Laryngoscope 2000; 110: 994–9.
11. Gul M, Okur E, Ciragil P et al. The comparison of tonsillar surface and core cultures in recurrent tonsillitis. Am J Otolaryngol 2007; 28: 173–6.
12. Kasenomm P, Piirsoo A, Kull M et al. Selection of indicators for tonsillectomy in adults with recurrent tonsillitis. BMC Ear Nose Throat Disord 2005; 5: 7.
13. Skoulakis C, Tigiroglou E, Gkarelis K et al. Level of Streptococcus pyogenes in patients with recurrent tonsillitis and tonsillar hypertrophy. Scand J Infect Dis 2008; 40: 899–903.
14. Azovskova O.V., Kozlov R.S., Krechikova O.I., Ivanchik N.V. Dinamika antibiotikorezistentnosti respiratornykh shtammov Streptococcus pyogenes v Rossii za period 1999–2009 gg. Klin. mikrobiologiya i antimikrob. khimioterapiya. 2012; 14 (4): 309–21. [in Russian]
15. Uppal K, Bais AS. Tonsillar microflora, superficial surface versus deep. J Laryngol Otol 1989; 103: 175–7.
16. Inci E, Kakakullukcu B, Aygun G, Ozdogan A. Tonsil surface and core microflora in children undergone tonsillectomy for recurrent tonsillitis. Turkish Otolaryngol Arch 2002; 40 (4): 247–51.
17. Zatner AE, Krause M, Stropahl G. Intracellular Persisting Staphylococcus aureus Is the Major Pathogen in Recurrent Tonsillitis. PLoS ONE 2010; 5 (30): 1–16.
18. Lee PK, Schlievert PM. Molecular genetics of pyrogenic exotoxin «superantigens» of group A streptococci and Staphylococcus aureus. Curr Top Microbiol Immunol 1991; 174: 1–19. DOI: 10.1007/978-3-642-50998-8_1.
19. Reinert RR. Streptokokken-Infektionen – Aktuelle Aspekte zur Diagnostik, Prophylaxe und Therapie. 1st ed. Bremen: UNI-MED Science, 2007.
2. Iqbal FR, Goh BS, Mazita A. The role of proton pump inhibitors in adenoid hypertrophy in children. Otolaryngol Head Neck Surg 2012; 147 (2): 329–34.
3. Allegrucci M et al. Phenotypic characterization of Streptococcus pneumoniae biofilm development. J Bacteriol 2006; 188 (7): 2325 –35.
4. Карпищенко С.А., Колесникова О.М. Возможности лечения острой боли в горле. Врач. 2014; 2: 19–23. / Karpishchenko S.A., Kolesnikova O.M. Vozmozhnosti lecheniya ostroy boli v gorle. Vrach. 2014; 2: 19–23. [in Russian]
5. McIsaac WJ, Kellner JD, Aufricht P et al. Empirical validation of guidelines for the management of pharyngitis in children and adults. JAMA 2004; 291: 1587–1595. Erratum in: JAMA 2005; 294: 2700.
6. Timon CI, McAllister VA, Walsh MA, Cafferkey MT. Changes in tonsil bacteriology of recurrent acute tonsillitis: 1980 vs 1989. Respir Med 1990; 84: 395–400.
7. Kumai A, Gupta V, Chandra K et al. Clinico bacteriological evaluation of surface and core microflora in chronic tonsillitis. Indian J Otolaryngol Head Neck Surg 2005; 57 (2): 118–20.
8. Mitchelmore IJ, Reilly PG, Hay AJ, Tabaqchali S. Tonsil surface and core cultures in recurrent tonsillitis: prevalence of anaerobes and beta-lactamase producing organisms. Eur J Clin Microbiol Infect Dis 1994; 13 (7): 542–8.
9. Журавлев А.С. Микробиологическое обоснование эффективности различных способов лечения больных с хроническим компенсированным тонзиллитом. Folia Otorhinolaryngologica 2014; 20 (1): 42–8. / Zhuravlev A.S. Mikrobiologicheskoe obosnovanie effektivnosti razlichnykh sposobov lecheniya bol'nykh s khronicheskim kompensirovannym tonzillitom. Folia Otorhinolaryngologica 2014; 20 (1): 42–8. [in Russian]
10. Brook I, Shah K, Jackson W. Microbiology of healthy and diseased adenoids. Laryngoscope 2000; 110: 994–9.
11. Gul M, Okur E, Ciragil P et al. The comparison of tonsillar surface and core cultures in recurrent tonsillitis. Am J Otolaryngol 2007; 28: 173–6.
12. Kasenomm P, Piirsoo A, Kull M et al. Selection of indicators for tonsillectomy in adults with recurrent tonsillitis. BMC Ear Nose Throat Disord 2005; 5: 7.
13. Skoulakis C, Tigiroglou E, Gkarelis K et al. Level of Streptococcus pyogenes in patients with recurrent tonsillitis and tonsillar hypertrophy. Scand J Infect Dis 2008; 40: 899–903.
14. Азовскова О.В., Козлов Р.С., Кречикова О.И., Иванчик Н.В. Динамика антибиотикорезистентности респираторных штаммов Streptococcus pyogenes в России за период 1999–2009 гг. Клин. микробиология и антимикроб. химиотерапия. 2012; 14 (4): 309–21. / Azovskova O.V., Kozlov R.S., Krechikova O.I., Ivanchik N.V. Dinamika antibiotikorezistentnosti respiratornykh shtammov Streptococcus pyogenes v Rossii za period 1999–2009 gg. Klin. mikrobiologiya i antimikrob. khimioterapiya. 2012; 14 (4): 309–21. [in Russian]
15. Uppal K, Bais AS. Tonsillar microflora, superficial surface versus deep. J Laryngol Otol 1989; 103: 175–7.
16. Inci E, Kakakullukcu B, Aygun G, Ozdogan A. Tonsil surface and core microflora in children undergone tonsillectomy for recurrent tonsillitis. Turkish Otolaryngol Arch 2002; 40 (4): 247–51.
17. Zatner AE, Krause M, Stropahl G. Intracellular Persisting Staphylococcus aureus Is the Major Pathogen in Recurrent Tonsillitis. PLoS ONE 2010; 5 (30): 1–16.
18. Lee PK, Schlievert PM. Molecular genetics of pyrogenic exotoxin «superantigens» of group A streptococci and Staphylococcus aureus. Curr Top Microbiol Immunol 1991; 174: 1–19. DOI: 10.1007/978-3-642-50998-8_1.
19. Reinert RR. Streptokokken-Infektionen – Aktuelle Aspekte zur Diagnostik, Prophylaxe und Therapie. 1st ed. Bremen: UNI-MED Science, 2007.
________________________________________________
2. Iqbal FR, Goh BS, Mazita A. The role of proton pump inhibitors in adenoid hypertrophy in children. Otolaryngol Head Neck Surg 2012; 147 (2): 329–34.
3. Allegrucci M et al. Phenotypic characterization of Streptococcus pneumoniae biofilm development. J Bacteriol 2006; 188 (7): 2325 –35.
4. Karpishchenko S.A., Kolesnikova O.M. Vozmozhnosti lecheniya ostroy boli v gorle. Vrach. 2014; 2: 19–23. [in Russian]
5. McIsaac WJ, Kellner JD, Aufricht P et al. Empirical validation of guidelines for the management of pharyngitis in children and adults. JAMA 2004; 291: 1587–1595. Erratum in: JAMA 2005; 294: 2700.
6. Timon CI, McAllister VA, Walsh MA, Cafferkey MT. Changes in tonsil bacteriology of recurrent acute tonsillitis: 1980 vs 1989. Respir Med 1990; 84: 395–400.
7. Kumai A, Gupta V, Chandra K et al. Clinico bacteriological evaluation of surface and core microflora in chronic tonsillitis. Indian J Otolaryngol Head Neck Surg 2005; 57 (2): 118–20.
8. Mitchelmore IJ, Reilly PG, Hay AJ, Tabaqchali S. Tonsil surface and core cultures in recurrent tonsillitis: prevalence of anaerobes and beta-lactamase producing organisms. Eur J Clin Microbiol Infect Dis 1994; 13 (7): 542–8.
9. Zhuravlev A.S. Mikrobiologicheskoe obosnovanie effektivnosti razlichnykh sposobov lecheniya bol'nykh s khronicheskim kompensirovannym tonzillitom. Folia Otorhinolaryngologica 2014; 20 (1): 42–8. [in Russian]
10. Brook I, Shah K, Jackson W. Microbiology of healthy and diseased adenoids. Laryngoscope 2000; 110: 994–9.
11. Gul M, Okur E, Ciragil P et al. The comparison of tonsillar surface and core cultures in recurrent tonsillitis. Am J Otolaryngol 2007; 28: 173–6.
12. Kasenomm P, Piirsoo A, Kull M et al. Selection of indicators for tonsillectomy in adults with recurrent tonsillitis. BMC Ear Nose Throat Disord 2005; 5: 7.
13. Skoulakis C, Tigiroglou E, Gkarelis K et al. Level of Streptococcus pyogenes in patients with recurrent tonsillitis and tonsillar hypertrophy. Scand J Infect Dis 2008; 40: 899–903.
14. Azovskova O.V., Kozlov R.S., Krechikova O.I., Ivanchik N.V. Dinamika antibiotikorezistentnosti respiratornykh shtammov Streptococcus pyogenes v Rossii za period 1999–2009 gg. Klin. mikrobiologiya i antimikrob. khimioterapiya. 2012; 14 (4): 309–21. [in Russian]
15. Uppal K, Bais AS. Tonsillar microflora, superficial surface versus deep. J Laryngol Otol 1989; 103: 175–7.
16. Inci E, Kakakullukcu B, Aygun G, Ozdogan A. Tonsil surface and core microflora in children undergone tonsillectomy for recurrent tonsillitis. Turkish Otolaryngol Arch 2002; 40 (4): 247–51.
17. Zatner AE, Krause M, Stropahl G. Intracellular Persisting Staphylococcus aureus Is the Major Pathogen in Recurrent Tonsillitis. PLoS ONE 2010; 5 (30): 1–16.
18. Lee PK, Schlievert PM. Molecular genetics of pyrogenic exotoxin «superantigens» of group A streptococci and Staphylococcus aureus. Curr Top Microbiol Immunol 1991; 174: 1–19. DOI: 10.1007/978-3-642-50998-8_1.
19. Reinert RR. Streptokokken-Infektionen – Aktuelle Aspekte zur Diagnostik, Prophylaxe und Therapie. 1st ed. Bremen: UNI-MED Science, 2007.
Авторы
С.А.Карпищенко, О.М.Колесникова*
ГБОУ ВПО Первый Санкт-Петербургский государственный медицинский университет им. И.П.Павлова Минздрава России. 197022, Россия, Санкт-Петербург, ул. Льва Толстого, д. 6/8
*olga_lozo@mail.ru
I.P.Pavlov First Saint Petersburg State Medical University of the Ministry of Health of the Russian Federation. 197022, Russian Federation, Saint Petersburg, ul. L'va Tolstogo, d. 6/8
*olga_lozo@mail.ru
ГБОУ ВПО Первый Санкт-Петербургский государственный медицинский университет им. И.П.Павлова Минздрава России. 197022, Россия, Санкт-Петербург, ул. Льва Толстого, д. 6/8
*olga_lozo@mail.ru
________________________________________________
I.P.Pavlov First Saint Petersburg State Medical University of the Ministry of Health of the Russian Federation. 197022, Russian Federation, Saint Petersburg, ul. L'va Tolstogo, d. 6/8
*olga_lozo@mail.ru
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