Представлены клинические проявления ограниченной и системной склеродермии у детей, лабораторные и инструментальные методы диагностики заболевания. Приведены принципы современной немедикаментозной и медикаментозной терапии склеродермии у детей.
Ключевые слова: склеродермия у детей, клинические проявления, диагностика, принципы терапии.
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Presented are clinical manifestations and limited systemic sclerosis in children, laboratory and instrumental methods of diagnosis of the disease. The principles of modern non-pharmacological and pharmacological treatment of scleroderma in children are also discussed.
Key words: scleroderma in children, clinical manifestations, diagnosis, treatment principles.
1. Zulian F, Avcin T, Foeidvari I et al. The juvenile scleroderma international database: an instrument for improving research and standard of care in rare disease of childhood. Ann Rheum Dis 2007; 66 (Suppl. 11).
2. Zulian F, Athreya B, Laxer R, Nelson A et al. Juvenile localized scleroderma: clinical and epidemiological features in 750 children. An international study. J Rheumatol 2006; 45: 614–20.
3. Fitch PG, Rettig P, Burnham JM et al. Treatment of pediatric localized scleroderma with methotrexate. J Rheumatol 2006; 33 (3): 609–14.
4. Athreya BH. Juvenile scleroderma. Curr Opin Rheumatol 2002; 14: 553–61.
5. Zulian F. Systemic sclerosis and localized scleroderma in childhood. Rheum Dis Clin North Am 2008; 34: 239–55.
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1. Zulian F, Avcin T, Foeidvari I et al. The juvenile scleroderma international database: an instrument for improving research and standard of care in rare disease of childhood. Ann Rheum Dis 2007; 66 (Suppl. 11).
2. Zulian F, Athreya B, Laxer R, Nelson A et al. Juvenile localized scleroderma: clinical and epidemiological features in 750 children. An international study. J Rheumatol 2006; 45: 614–20.
3. Fitch PG, Rettig P, Burnham JM et al. Treatment of pediatric localized scleroderma with methotrexate. J Rheumatol 2006; 33 (3): 609–14.
4. Athreya BH. Juvenile scleroderma. Curr Opin Rheumatol 2002; 14: 553–61.
5. Zulian F. Systemic sclerosis and localized scleroderma in childhood. Rheum Dis Clin North Am 2008; 34: 239–55.
Авторы
М.К.Осминина*
ГБОУ ВПО Первый Московский государственный медицинский университет им. И.М.Сеченова Минздрава России. 119991, Россия, Москва, ул. Большая Пироговская, д. 19
*mk_osminina@mail.ru
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M.K.Osminina*
I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation. 119991, Russian Federation, Moscow, ul. Bol'shaya Pirogovskaya, d. 19
*mk_osminina@mail.ru